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Functional classification of pulmonary. Hypertension

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https://www.readbyqxmd.com/read/27837039/low-risk-for-local-and-systemic-complications-after-primary-repair-of-1626-achilles-tendon-ruptures
#1
Nicholas Rensing, Brian R Waterman, Rachel M Frank, Kenneth A Heida, Justin D Orr
INTRODUCTION: Historically, Achilles tendon repairs and other surgeries about the hindfoot have demonstrated a significantly higher rate of wound healing complications and surgical site morbidity. The purpose of this study was to evaluate the comprehensive complication profile and risk factors for adverse short-term, clinical outcomes after primary repair of Achilles tendon ruptures. METHODS: Between the years 2005 and 2014, all cases of primary Achilles tendon repair (Current Procedural Terminology code 27650) entered into the National Surgical Quality Improvement Project (NSQIP) database were extracted for analysis...
November 10, 2016: Foot & Ankle Specialist
https://www.readbyqxmd.com/read/27826710/the-action-of-smooth-muscle-cell-potassium-channels-in-the-pathology-of-pulmonary-arterial-hypertension
#2
REVIEW
Yasunobu Hayabuchi
Many different types of potassium channels with various functions exist in pulmonary artery smooth muscle cells, contributing to many physiological actions and pathological conditions. The deep involvement of these channels in the onset and exacerbation of pulmonary arterial hypertension (PAH) also continues to be revealed. In 2013, KCNK3 (TASK1), which encodes a type of two-pore domain potassium channel, was shown to be a predisposing gene for PAH by genetic mutation, and it was added to the PAH classification at the Fifth World Symposium on Pulmonary Hypertension (Nice International Conference)...
November 8, 2016: Pediatric Cardiology
https://www.readbyqxmd.com/read/27739097/acute-effect-of-iloprost-inhalation-on-right-atrial-function-and-ventricular-dyssynchrony-in-patients-with-pulmonary-artery-hypertension
#3
Luigi Gabrielli, María Paz Ocaranza, Marta Sitges, Andrés Kanacri, Rodrigo Saavedra, Pablo Sepulveda, Luis Sepulveda, Victor Rossel, Monica Zagolin, Hugo E Verdejo, Fernando Baraona, Ricardo Zalaquett, Mario Chiong, Sergio Lavandero, Pablo F Castro
BACKGROUND: Right atrium function and ventricular function have significant prognostic value in pulmonary arterial hypertension patients. Acute changes in right ventricular synchrony and right atrium function postiloprost inhalation have not been evaluated. METHODS: Cross-sectional study. Consecutive pulmonary arterial hypertension patients (group I from Nice classification) were included. Echocardiographic right atrium and right ventricular function pre- and postiloprost inhalation, including a right ventricular dyssynchrony index and right atrium function using speckle tracking, were performed in all patients...
October 14, 2016: Echocardiography
https://www.readbyqxmd.com/read/27636399/which-type-of-valve-should-we-use-in-tricuspid-position-long-term-comparison-between-mechanical-and-biological-valves
#4
Ana Redondo Palacios, José López Menéndez, Javier Miguelena Hycka, Miren Martín García, Laura Varela Barca, Andrea Ferreiro Marzal, Rafael Muñoz Pérez, Enrique Oliva De Anquín, Ignacio García Andrade, Tomasa Centella Hernández, Daniel Celemín Canorea, Jorge Rodríguez-Roda Stuart
BACKGROUND: Nowadays, Tricuspid valve replacement (TVR) is much less common than aortic or mitral valve replacement, since repair is almost always preferable. Prosthetic tricuspid valves are associated with high mortality and morbidity, mostly due to thrombotic or hemorrhagic events. Nevertheless, there is lack of evidence of which is the optimal type of valve (biological versus mechanical) in tricuspid position. METHODS: We analysed all the patients who underwent TVR in our Institution, from 2005 to 2015...
September 16, 2016: Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/27603702/transthoracic-echocardiography-and-chest-computed-tomography-arteriography-in-patients-with-acute-pulmonary-embolism-a-two-year-follow-up-study
#5
Walter Serra, Ernesto Crisafulli, Nicola Sverzellati, P Tito Ugolotti, Panajota Tzani, Emilio Marangio, Diego Ardissino, Tiziano Gherli, Alfredo Chetta
BACKGROUND: Pulmonary hypertension (PH) is frequently found at the time of diagnosis of pulmonary embolism (PE). An incomplete resolution of PE can lead to chronic thromboembolic pulmonary hypertension (CTPH). Transthoracic echocardiogram (TTE) is the first step to diagnose an abnormality of the pulmonary vasculature. Based on computed tomography (CT), the Qanadli vascular obstruction index has been extensively used to assess acute PE. OBJECTIVES: Our aim was to ascertain whether at the time of diagnosis of an acute PE episode TTE variables and a Qanadli CT index score may be associated with CTPH 2 years later...
2016: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/27541954/non-invasive-diagnosis-of-pulmonary-hypertension-from-lung-doppler-signal-a-proof-of-concept-study
#6
Laurent Godinas, Frédéric Lador, Rachel Schatzberger, Sven Günther, Michael J Segel, Yoram Palti, Ernesto Maisuls, Olivier Sitbon, Gérald Simonneau
Transthoracic Parametric Doppler (TPD) is a novel ultrasound technique recently developed for the investigation of pulmonary blood vessels. Lung Doppler Signals (LDS) recorded from TPD provide information regarding the functional mechanical characteristics of pulmonary blood vessels. We aimed to define the specific profile of LDS generated from TPD imaging in patients with pulmonary hypertension (PH), and to evaluate the diagnostic performance of LDS to detect PH using right heart catheterization (RHC) as gold standard reference...
August 19, 2016: Journal of Clinical Monitoring and Computing
https://www.readbyqxmd.com/read/27490592/pulmonary-hypertension
#7
Peter Oishi, Jeffrey R Fineman
OBJECTIVES: To review the clinical classification, diagnosis, and pathophysiology of pulmonary hypertension in children, emphasizing the role of right ventricular function, ventricular interaction, and congenital heart disease in the evolution and progression of disease, as well as management strategies and therapeutic options. DATA SOURCE: MEDLINE, PubMed. CONCLUSIONS: Critically ill children with pulmonary hypertension associated with congenital heart disease are a high-risk population...
August 2016: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/27252844/diagnosis-of-pulmonary-hypertension-from-magnetic-resonance-imaging-based-computational-models-and-decision-tree-analysis
#8
Angela Lungu, Andrew J Swift, David Capener, David Kiely, Rod Hose, Jim M Wild
Accurately identifying patients with pulmonary hypertension (PH) using noninvasive methods is challenging, and right heart catheterization (RHC) is the gold standard. Magnetic resonance imaging (MRI) has been proposed as an alternative to echocardiography and RHC in the assessment of cardiac function and pulmonary hemodynamics in patients with suspected PH. The aim of this study was to assess whether machine learning using computational modeling techniques and image-based metrics of PH can improve the diagnostic accuracy of MRI in PH...
June 2016: Pulmonary Circulation
https://www.readbyqxmd.com/read/27149246/the-role-of-an-activity-monitor-in-the-objective-evaluation-of-patients-with-pulmonary-hypertension
#9
Gulfer Okumus, Goksen Kuran Aslan, Orhan Arseven, Gul Ongen, Halim Issever, Esen Kıyan
INTRODUCTION: Patients with pulmonary hypertension (PH) show no symptoms at rest, but symptoms are triggered by physical activities. OBJECTIVES: The primary aim of our study was to assess physical activity of patients with PH by using an activity monitor. The secondary aim was to evaluate the correlation between the activity monitor parameters and 6-minute walk distance (6MWD), activity of daily living (ADL), quality of life, WHO functional class, and PH classification...
May 5, 2016: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/27144613/left-atrial-intrinsic-strain-rate-correcting-for-pulmonary-wedge-pressure-is-accurate-in-estimating-pulmonary-vascular-resistance-in-breathless-patients
#10
Erik Tossavainen, Michael Y Henein, Christer Grönlund, Per Lindqvist
OBJECTIVES: We hypothesized that left atrial deformation during atrial systole (LASRa) correlates with pulmonary capillary wedge pressure (PCWP), thus enabling echo-derived pulmonary vascular resistance (PVR) estimation in a wide range of different subsets of patients. BACKGROUND: Various etiologies of pulmonary hypertension (PH) have different mechanisms and treatments for breathlessness. Irrespective of the location of the underlying pulmonary vascular pathology, pre- or postcapillary, the resulting PH is fairly easy to assess by Doppler echocardiography, but PVR remains a challenge...
August 2016: Echocardiography
https://www.readbyqxmd.com/read/27065171/adhesion-molecules-master-controllers-of-the-circulatory-system
#11
Eric P Schmidt, Wolfgang M Kuebler, Warren L Lee, Gregory P Downey
This manuscript will review our current understanding of cellular adhesion molecules (CAMs) relevant to the circulatory system, their physiological role in control of vascular homeostasis, innate and adaptive immune responses, and their importance in pathophysiological (disease) processes such as acute lung injury, atherosclerosis, and pulmonary hypertension. This is a complex and rapidly changing area of research that is incompletely understood. By design, we will begin with a brief overview of the structure and classification of the major groups of adhesion molecules and their physiological functions including cellular adhesion and signaling...
April 2016: Comprehensive Physiology
https://www.readbyqxmd.com/read/27053692/diagnostics-monitoring-and-outpatient-care-in-children-with-suspected-pulmonary-hypertension-paediatric-pulmonary-hypertensive-vascular-disease-expert-consensus-statement-on-the-diagnosis-and-treatment-of-paediatric-pulmonary-hypertension-the-european-paediatric
#12
REVIEW
Astrid E Lammers, Christian Apitz, Peter Zartner, Alfred Hager, Karl-Otto Dubowy, Georg Hansmann
Pulmonary hypertension (PH) is a condition of multiple aetiologies with underestimated prevalence and incidence. Indeed, despite access to modern therapies, pulmonary hypertensive vascular disease (PHVD) remains a progressive, usually life-limiting condition, severely impacting on the patients' well-being. We herein provide practical, expert consensus recommendations on the initial diagnostic work-up, clinical management and follow-up of children and adolescents with PH/PHVD, including a diagnostic algorithm...
May 2016: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/27003666/new-therapeutic-paradigms-and-guidelines-in-the-management-of-pulmonary-arterial-hypertension
#13
Nicholas S Hill, Michael J Cawley, Cherilyn L Heggen-Peay
BACKGROUND: Recent and ongoing developments in the diagnosis, treatment, and management of pulmonary arterial hypertension (PAH) provide deeper insights into pathogenic mechanisms. Approvals of new pharmacotherapies that improve function and reduce morbidity and mortality risks; advances in clinical trial methods, including long-term, event-driven studies with clinically relevant and patient-centered endpoints; and trial results support a new therapeutic management strategy. This new paradigm involves initial treatment with combined therapies that act through different disease pathways...
March 2016: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/26987595/lung-capillary-blood-volume-and-membrane-diffusion-in-precapillary-pulmonary-hypertension
#14
Laurent Godinas, David Amar, David Montani, Edmund M Lau, Xavier Jaïs, Laurent Savale, Mitja Jevnikar, Olivier Sitbon, Gérald Simonneau, Marc Humbert, Pierantonio Laveneziana, Gilles Garcia
BACKGROUND: Combined diffusion capacity of the lung for carbon monoxide (DLco) and nitric oxide (DLno) measurements allow for the estimation of pulmonary capillary blood volume (Vc) and alveolar membrane diffusion (Dm). The clinical usefulness of these measurements in pulmonary hypertension (PH) is unclear. METHODS: Combined DLco and DLno were measured in 290 consecutive patients with precapillary PH (pulmonary arterial hypertension (PAH), n = 153; pulmonary veno-occlusive disease (PVOD), n = 33; and chronic thromboembolic pulmonary hypertension (CTEPH), n = 104)...
May 2016: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/26897077/the-role-of-cystatin-c-as-a-biomarker-for-prognosis-in-pulmonary-arterial-hypertension-due-to-congenital-heart-disease
#15
Ilja M Blok, Annelieke C M J van Riel, Mark J Schuuring, Rianne H A C M de Bruin-Bon, Arie P J van Dijk, Elke S Hoendermis, Aeilko H Zwinderman, Barbara J M Mulder, Berto J Bouma
BACKGROUND: Adults with pulmonary arterial hypertension due to congenital heart disease (PAH-CHD) have a poor prognosis. Identifying patients with a high risk for clinical events and death is important because their prognosis can be improved by intensifying their treatment. Cystatin C, a novel cardiac biomarker, correlates with right ventricular dimensions in patients with idiopathic PAH, giving it potential to determine prognosis in PAH-CHD patients. We investigated the predictive value of cystatin C for long-term mortality and clinical events...
April 15, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/26843461/change-in-pediatric-functional-classification-during-treatment-and-morbidity-and-mortality-in-children-with-pulmonary-hypertension
#16
Emily Morell Balkin, Emma D Olson, Laura Robertson, Ian Adatia, Jeffrey R Fineman, Roberta L Keller
Despite advances in therapy, outcomes for children with pulmonary hypertension remain poor. We sought to assess the validity of a pediatric-specific functional classification system for pulmonary hypertension (PH) in a heterogeneous population of children with PH diagnosed by echocardiogram or cardiac catheterization. A single-center, retrospective study of 65 infants and children with PH was performed. Pediatric Functional Class (FC) at diagnosis, at last visit, and change in FC over time were evaluated for their association with mortality and PH-associated morbidity in univariate, time-to-event, and multivariate regression analyses...
April 2016: Pediatric Cardiology
https://www.readbyqxmd.com/read/26765478/increased-risks-of-spontaneous-bacterial-peritonitis-and-interstitial-lung-disease-in-primary-biliary-cirrhosis-patients-with-concomitant-sj%C3%A3-gren-syndrome
#17
Chun-Ting Chen, Yu-Chen Tseng, Chih-Wei Yang, Hsuan-Hwai Lin, Peng-Jen Chen, Tien-Yu Huang, Yu-Lueng Shih, Wei-Kuo Chang, Tsai-Yuan Hsieh, Heng-Cheng Chu
The incidence of Sjögren syndrome (SS) in primary biliary cirrhosis (PBC) patients is high. The influence of SS on the clinical outcomes of PBC patients, however, remains unclear. Our study retrospectively collected data on PBC-only patients and PBC patients with concomitant SS (PBC-SS) to compare the clinical differences of long-term outcomes between them.A total of 183 patients were diagnosed with PBC from January 1999 to December 2014 at our hospital. Of these, the authors excluded patients with diabetes, hypertension, advanced liver cirrhosis at initial diagnosis of PBC (Child-Turcotte-Pugh classification score of ≥7) and other liver diseases (ie, alcoholic liver disease, alpha-antitrypsin deficiency, viral hepatitis, and primary sclerosing cholangitis), and autoimmune diseases such as systemic lupus erythematosus and rheumatoid arthritis...
January 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/26700422/maternal-and-fetal-outcome-in-women-with-rheumatic-heart-disease-a-3-year-observational-study
#18
Mohamed Rezk, Awni Gamal
OBJECTIVE: To assess prospectively the maternal and fetal outcome in women with rheumatic heart disease (RHD). METHODS: This was a prospective 3-year observational study carried out at Menoufia University Hospital, Egypt in which 192 patients out of 9856 pregnant women were diagnosed with RHD and divided into two groups: low- and high-risk groups based on the New York Heart Association (NYHA) functional classification. Enrolled patients were followed to assess the maternal and fetal outcome...
August 2016: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/26567484/treat-and-repair-strategy-in-patients-with-atrial-septal-defect-and-significant-pulmonary-arterial-hypertension
#19
Yasufumi Kijima, Teiji Akagi, Yoichi Takaya, Satoshi Akagi, Koji Nakagawa, Kengo Kusano, Shunji Sano, Hiroshi Ito
BACKGROUND: A therapeutic strategy in patients with atrial septal defect (ASD) and significant pulmonary arterial hypertension (PAH) remains controversial. This study aimed to assess the effect of PAH-specific medications and subsequent transcatheter shunt closure (ie, a treat and repair strategy) in these patients. METHODS AND RESULTS: Among 646 patients with ASD, 22 patients (mean age of 56±20 years) who had PAH [mean pulmonary artery pressure ≥25 mmHg and pulmonary vascular resistance (PVR) ≥3 Wood units] underwent successful transcatheter ASD closure...
2016: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/26522749/the-role-of-echocardiography-in-the-evaluation-of-pulmonary-arterial-hypertension
#20
REVIEW
Nicole Pristera, Ray Musarra, Robert Schilz, Brian D Hoit
The evaluation of pulmonary arterial hypertension (PAH) requires a multimodality approach that combines invasive and noninvasive imaging studies to ensure accurate diagnosis and classification. Given the complexity of the hemodynamic relationships between the left heart, pulmonary circulation, and right heart, the diagnosis of PAH is often a challenging task. Right heart catheterization is the gold standard for diagnosis, providing the hemodynamic information that defines the disease. Nonetheless, echocardiography continues to be a valuable tool in the approach to the patient with suspected PAH...
January 2016: Echocardiography
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