Ouwen Qiu, Jianyi Zhao, Zhonggang Shi, Huan Li, Siyuan Wang, Keman Liao, Minchao Tang, Jieqiong Xie, Xi Huang, Wenrui Zhang, Li Zhou, Xi Yang, Zhiyi Zhou, Lei Xu, Renhua Huang, Yifeng Miao, Yongming Qiu, Yingying Lin
Mounting evidence supports the role of neuroinflammation in radiation-induced brain injury (RIBI), a chronic disease characterized by delayed and progressive neurological impairment. Asparagine endopeptidase (AEP), also known as legumain (LGMN), participates in multiple malignancies and neurodegenerative diseases and may potentially be involved in RIBI. Here, we found AEP expression was substantially elevated in the cortex and hippocampus of wild-type ( Lgmn +/+ ) mice following whole-brain irradiation. Lgmn knockout ( Lgmn -/- ) alleviated neurological impairment caused by whole-brain irradiation by suppressing neuronal senescence...
May 17, 2024: IScience