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High grade non muscle invasive bladder cancer

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https://www.readbyqxmd.com/read/28941000/increased-accuracy-of-a-novel-mrna-based-urine-test-for-bladder-cancer-surveillance
#1
Renate Pichler, Josef Fritz, Gennadi Tulchiner, Gerald Klinglmair, Afschin Soleiman, Wolfgang Horninger, Helmut Klocker, Isabel Heidegger
OBJECTIVES: To evaluate the diagnostic accuracy of the Xpert Bladder Cancer (BC) Monitor, compared to cystoscopy and cytology in the oncological follow-up of non-muscle invasive bladder cancer (NMIBC). MATERIAL AND METHODS: 140 patients with a previous history of NMIBC undergoing routine surveillance at our department were enrolled prospectively (ISRCTN study registry number 37210907). Urine cytology was evaluated according to the Paris classification system. In addition, urinary specimens were analyzed using the Xpert BC Monitor, which measures five target mRNAs (ABL1, CRH, IGF2, UPK1B, ANXA10) using real-time-PCR...
September 20, 2017: BJU International
https://www.readbyqxmd.com/read/28844793/utilization-and-outcomes-of-radical-cystectomy-for-high-grade-non-muscle-invasive-bladder-cancer-in-elderly-patients
#2
William P Parker, Woodson Smelser, Eugene K Lee, Elizabeth B Habermann, Prabin Thapa, Harras B Zaid, Igor Frank, Tomas L Griebling, Matthew K Tollefson, R Houston Thompson, Jeffrey M Holzbeierlein, R Jeffrey Karnes, Stephen A Boorjian
BACKGROUND: Radical cystectomy (RC) represents a treatment option for patients with high-grade non-muscle-invasive bladder cancer (HG-NMIBC); however, perioperative morbidity is not insignificant, particularly in elderly patients. We sought to evaluate the associations of age with utilization and outcomes of RC for HG-NMIBC. PATIENTS AND METHODS: Patients with HG-NMIBC diagnosed between 2004 and 2013 were identified in the National Cancer Database and stratified by age: ≤ 60, 61-70, 71-80, and > 80 years...
August 1, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28843746/cytological-and-histological-changes-in-the-urothelium-produced-by-electromotive-drug-administration-emda-and-by-the-combination-of-intravescical-hyperthermia-and-chemotherapy-thermochemotherapy
#3
Francesco Pierconti, Patrizia Straccia, Sacco Emilio, Pier Francesco Bassi, Ivana De Pascalis, Rita C Marques, Metka Volavsek, Luigi M Larocca, Antonio Lopez-Beltran
The treatment of non muscle-invasive bladder cancer (NMIBC) encompasses a range of different procedures. Electromotive drug administration (EMDA) and chemo-hyperthermia (C-HT; Synergo) represent a minimally-invasive methods of intravesical instillation of therapeutic agents as mitomycin C (MMC). We selected patients with high grade NMIBC, BCG non responder, treated with EMDA/MMC and C-HT/MMC and we also examined the morphological changes in urine cytology samples. During the period from 2012 to 2014, 110 patients with high grade NMIBC, BCG refractory were selected...
August 1, 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28837258/diagnostic-and-prognostic-role-of-urinary-collagens-in-primary-human-bladder-cancer
#4
Makito Miyake, Yosuke Morizawa, Shunta Hori, Yoshihiro Tatsumi, Sayuri Onishi, Takuya Owari, Kota Iida, Kenta Onishi, Daisuke Goto, Yasushi Nakai, Satoshi Anai, Yoshitomo Chihara, Kazumasa Torimoto, Katsuya Aoki, Nobumichi Tanaka, Keiji Shimada, Noboru Konishi, Kiyohide Fujimoto
Collagen type 4 alpha 1 (COL4A1) and collagen type 13 alpha 1 (COL13A1) produced by urothelial cancer cells support the vital oncogenic property of tumor invasion. We investigated the diagnostic and prognostic capability of COL4A1 and COL13A1 in voided urine and compared the observed values with those of CYFRA21-1, NMP-22, and voided urine cytology in bladder cancer (BCa). We collected voided urine samples from 154 patients newly diagnosed with BCa, before surgery and from 61 control subjects. Protein levels of COL4A1, COL13A1, CYFRA21-1, and NMP-22 in urine supernatants were measured using enzyme-linked immunosorbent assays...
August 24, 2017: Cancer Science
https://www.readbyqxmd.com/read/28834453/intravesical-rad-ifn%C3%AE-syn3-for-patients-with-high-grade-bacillus-calmette-guerin-refractory-or-relapsed-non-muscle-invasive-bladder-cancer-a-phase-ii-randomized-study
#5
Neal D Shore, Stephen A Boorjian, Daniel J Canter, Kenneth Ogan, Lawrence I Karsh, Tracy M Downs, Leonard G Gomella, Ashish M Kamat, Yair Lotan, Robert S Svatek, Trinity J Bivalacqua, Robert L Grubb, Tracey L Krupski, Seth P Lerner, Michael E Woods, Brant A Inman, Matthew I Milowsky, Alan Boyd, F Peter Treasure, Gillian Gregory, David G Sawutz, Seppo Yla-Herttuala, Nigel R Parker, Colin P N Dinney
Purpose Many patients with high-risk non-muscle-invasive bladder cancer (NMIBC) are either refractory to bacillus Calmette-Guerin (BCG) treatment or may experience disease relapse. We assessed the efficacy and safety of recombinant adenovirus interferon alfa with Syn3 (rAd-IFNα/Syn3), a replication-deficient recombinant adenovirus gene transfer vector, for patients with high-grade (HG) BCG-refractory or relapsed NMIBC. Methods In this open-label, multicenter (n = 13), parallel-arm, phase II study ( ClinicalTrials...
August 23, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28818537/predicting-grade-and-stage-at-cystoscopy-in-newly-presenting-bladder-cancers-a-prospective-double-blind-clinical-study
#6
Paramananthan Mariappan, Victoria Lavin, Chu Qin Phua, Shahid Aziz Anwar Khan, Roland Donat, Gordon Smith
OBJECTIVE: To assess urologists' ability to predict the grade and stage of new bladder cancers from the cystoscopic features alone. PATIENTS AND METHODS: We conducted a prospective clinical study on consecutive patients who underwent transurethral resection of bladder tumor (TURBT) for new bladder cancers. Using only cystoscopic tumor morphology at the time of initial TURBT, 3 urology consultants predicted the grade and stage, recording these on a proforma along with tumor features...
August 14, 2017: Urology
https://www.readbyqxmd.com/read/28801026/quadruple-immunotherapy-of-bacillus-calmette-gu%C3%A3-rin-interferon-interleukin-2-and-granulocyte-macrophage-colony-stimulating-factor-as-salvage-therapy-for-non-muscle-invasive-bladder-cancer
#7
Ryan L Steinberg, Kenneth G Nepple, Kyla N Velaer, Lewis J Thomas, Michael A O'Donnell
BACKGROUND: Bacillus Calmette-Guérin (BCG) is the most effective initial intravesical therapy for high-grade non-muscle invasive bladder cancer, but many patients still fail. Combination intravesical BCG and interferon (IFN) will salvage some patients but results remain suboptimal. OBJECTIVE: We hypothesized that further immunostimulation with intravesical interleukin-2 and subcutaneous granulocyte-macrophage colony-stimulating factor may improve response to intravesical BCG and IFN in patient with prior BCG failure(s)...
August 8, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28755959/an-open-label-single-arm-phase-ii-multicenter-study-of-the-safety-and-efficacy-of-cg0070-oncolytic-vector-regimen-in-patients-with-bcg-unresponsive-non-muscle-invasive-bladder-cancer-interim-results
#8
Vignesh T Packiam, Donald L Lamm, Daniel A Barocas, Andrew Trainer, Benjamin Fand, Ronald L Davis, William Clark, Michael Kroeger, Igor Dumbadze, Karim Chamie, A Karim Kader, Dominic Curran, John Gutheil, Arthur Kuan, Alex W Yeung, Gary D Steinberg
OBJECTIVES: CG0070 is a replication-competent oncolytic adenovirus that targets bladder tumor cells through their defective retinoblastoma pathway. Prior reports of intravesical CG0070 have shown promising activity in patients with high-grade non-muscle invasive bladder cancer (NMIBC) who previously did not respond to bacillus Calmette-Guérin (BCG). However, limited accrual has hindered analysis of efficacy, particularly for pathologic subsets. We evaluated interim results of a phase II trial for intravesical CG0070 in patients with BCG-unresponsive NMIBC who refused cystectomy...
July 26, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28689694/is-restaging-transurethral-resection-necessary-in-patients-with-non-muscle-invasive-bladder-cancer-and-limited-lamina-propria-invasion
#9
François Audenet, Caitlyn Retinger, Christine Chien, Nicole E Benfante, Bernard H Bochner, S Machele Donat, Harry W Herr, Guido Dalbagni
OBJECTIVES: To evaluate the influence of lamina propria invasion type at initial transurethral resection (TUR) on restaging pathology. MATERIALS AND METHODS: We reviewed prospectively maintained records of all patients with a high-grade pT1 nonmuscle invasive bladder cancer who underwent both initial and restaging TUR within 6 weeks at our center between 2001 and 2016. The pathology of second TUR specimens was analyzed with regard to the characteristics of lamina propria invasion found at initial resection...
July 6, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28679178/effectivity-of-intravescical-thermo-chemotherapy-prophylaxis-for-patients-with-high-recurrence-and-progression-risk-for-non-muscle-invasive-bladder-cancer
#10
Ali Serdar Gözen, Paolo Umari, Walter Scheitlin, Fuat Ernis Su, Yigit Akin, Jens Rassweiler
Background&Aim: High grade non-muscle invasive bladder cancer (NMIBC) is common in urological practice. Most of these cancers are or become refractory to intravesical immunotherapy and chemotherapy. Here we evaluated the efficacy of combined local bladder hyperthermia and intravesical mitomycin-C (MMC) instillation in patients with high-risk recurrent NMIBC. MATERIALS AND METHODS: Between February 2014 and December 2015, 18 patients with high risk NMIBC were enrolled. Patients were treated in an outpatient basis with 6 weekly induction sessions followed by monthly maintenance sessions with intravesical MMC in local hyperthermia with bladder wall thermo-chemotherapy (BWT) system (PelvixTT system, Elmedical Ltd...
June 30, 2017: Archivio Italiano di Urologia, Andrologia
https://www.readbyqxmd.com/read/28666721/follow-up-of-high-risk-bladder-cancer-is-it-safe-to-perform-fluorescence-endoscopy-multiple-times-in-the-same-patient
#11
Maria Apfelbeck, Tobias Grimm, Alexander Kretschmer, Alexander Buchner, Birte-Swantje Schneevoigt, Friedrich Jokisch, Markus Grabbert, Gerald Schulz, Christian G Stief, Alexander Karl
PURPOSE: As the use of fluorescence endoscopy is recommended today by different guidelines during the follow-up of high-grade non-muscle-invasive bladder cancer, the aim of this study is to analyze whether the multiple use of hexylaminolevulinate (HAL) for TUR-BT can be performed safely within the same patient over a time interval. METHODS: Data of patients diagnosed and treated with HAL-TUR-B at our institute between 2008 and 2013 were analyzed. Special interest was given to side effects observed during the instillation of the substance, on the whole day of the instillation and during the entire hospital stay...
June 27, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28648755/high-expression-of-long-noncoding-rna-malat1-indicates-a-poor-prognosis-and-promotes-clinical-progression-and-metastasis-in%C3%A2-bladder-cancer
#12
Chao Li, Yu Cui, Long-Fei Liu, Wen-Biao Ren, Qia-Qia Li, Xu Zhou, Yang-Le Li, Yang Li, Xiang-Yang Bai, Xiong-Bing Zu
BACKGROUND: Recent studies have demonstrated that the expression of long noncoding RNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) promotes cancer cell proliferation, invasion, and metastasis in many tumor types, but the association between bladder cancer and MALAT1 remains unknown. MATERIALS: The expression of MALAT1 was tested by in situ hybridization (ISH) in 120 bladder cancer specimens. The association between MALAT1 expression and clinicopathological features and prognosis of the patients with bladder cancer was analyzed...
May 10, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28586118/a-dna-hypermethylation-profile-reveals-new-potential-biomarkers-for-the-evaluation-of-prognosis-in-urothelial-bladder-cancer
#13
Jose I López, Javier C Angulo, Ana Martín, Manuel Sánchez-Chapado, Ana González-Corpas, Begoña Colás, Santiago Ropero
DNA hypermethylation has emerged as a molecular biomarker for the evaluation of cancer diagnosis and prognosis. We define a methylation signature of bladder cancer and evaluate whether this profile assesses prognosis of patients. Genome-wide methylation analysis was performed on 70 tumor and 10 normal bladder samples. Hypermethylation status of 1505 CpGs present in the promoter region of 807 genes was studied. Thirty-three genes were significantly hypermethylated in ≥10% of the tumors. Three clusters of patients were characterized by their DNA methylation profile, one at higher risk of dead of disease (p = 0...
September 2017: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/28583312/prognostic-impact-of-a-12-gene-progression-score-in-non-muscle-invasive-bladder-cancer-a-prospective-multicentre-validation-study
#14
Lars Dyrskjøt, Thomas Reinert, Ferran Algaba, Emil Christensen, Daan Nieboer, Gregers G Hermann, Karin Mogensen, Willemien Beukers, Mirari Marquez, Ulrika Segersten, Søren Høyer, Benedicte P Ulhøi, Arndt Hartmann, Robert Stöhr, Sven Wach, Roman Nawroth, Kristina Schwamborn, Cane Tulic, Tatjana Simic, Kerstin Junker, Niels Harving, Astrid C Petersen, Jørgen B Jensen, Bastian Keck, Marc-Oliver Grimm, Marcus Horstmann, Tobias Maurer, Ewout W Steyerberg, Ellen C Zwarthoff, Francisco X Real, Núria Malats, Per-Uno Malmström, Torben F Ørntoft
BACKGROUND: Progression of non-muscle-invasive bladder cancer (NMIBC) to muscle-invasive bladder cancer (MIBC) is life-threatening and cannot be accurately predicted using clinical and pathological risk factors. Biomarkers for stratifying patients to treatment and surveillance are greatly needed. OBJECTIVE: To validate a previously developed 12-gene progression score to predict progression to MIBC in a large, multicentre, prospective study. DESIGN, SETTING, AND PARTICIPANTS: We enrolled 1224 patients in ten European centres between 2008 and 2012...
June 2, 2017: European Urology
https://www.readbyqxmd.com/read/28579804/expression-of-urinary-mirnas-targeting-nlrs-inflammasomes-in-bladder-cancer
#15
Ettore Mearini, Giulia Poli, Giovanni Cochetti, Andrea Boni, Maria Giulia Egidi, Stefano Brancorsini
AIM OF THE STUDY: Inflammasome, a large complex of NOD-like receptors (NLRs), drives tumor growth and progression. The present study aimed at exploring the alteration in expression of urinary inflammasome-related microRNAs (miRNAs) in bladder cancer (BC). Our previous report demonstrated the up-regulation of NLRs genes (NLRP3, NLRP4, NLRP9 and NAIP) in urine sediments of patients harboring BC. The expression levels of miRNAs targeting these NLRs (miR-146a-5p, miR-106a-5p, miR-17-5p, miR-223-3p, miR-141-3p, miR-19a-3p, miR-145-5p, miR-185-5p) were assayed in the same patient cohort...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28577928/renal-tuberculosis-following-intravesical-bacillus-calmette-gu%C3%A3-rin-for-high-grade-non-muscle-invasive-bladder-cancer
#16
Neha Sihra, Nonaka Diasuke, Ramesh Thurairaja, Muhammad Shamim Khan, Sachin Malde
A 47-year-old man presented to the urology department with visible hematuria. He was found to have a high-grade non-muscle-invasive transitional cell carcinoma of the bladder and was subsequently treated with intravesical Bacillus Calmette-Guérin instillations. On routine surveillance computed tomography scan following treatment, he was found to have multiple rounded areas of low density in the right kidney, suspicious for renal malignancy. He underwent renal biopsy that revealed necrotizing granulomatous inflammation suggestive of mycobacterial infection...
May 31, 2017: Urology
https://www.readbyqxmd.com/read/28560602/progression-to-t1-high-grade-t1hg-from-a-lower-stage-grade-is-associated-with-poorer-survival-outcomes-than-initial-diagnosis-with-t1hg-bladder-cancer
#17
Jung Kwon Kim, Chang Wook Jeong, Cheol Kwak, Hyun Hoe Kim, Ja Hyeon Ku
BACKGROUND: Several studies have documented a poor prognosis in those patients who were initially diagnosed with non-muscle-invasive bladder cancer (NMBIC) and progressed to muscle-invasive bladder cancer (MIBC) compared with those who initially presented with MIBC. However, studies regarding this issue have not yet been performed in patients with T1 high-grade (T1HG) tumor. We aimed to compare survival outcomes between patients diagnosed as T1HG after initial transurethral resection of the bladder tumor (TUR-BT) and patients who presented with lower stage and/or grade but progressed to T1HG at the time of tumor recurrence...
May 30, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28554751/correlations-of-foxo3-and-foxo4-expressions-with-clinicopathological-features-and-prognosis-of-bladder-cancer
#18
Yang Wang, Xin-Li Kang, Fan-Chang Zeng, Cong-Jie Xu, Jia-Quan Zhou, Dong-Ni Luo
OBJECTIVE: The study is performed to explore the correlations of forkhead box O3 (FoxO3) and forkhead box O4 (FoxO4) expressions with clinicopathological features and prognosis of bladder cancer. METHODS: Bladder cancer tissues and adjacent normal tissues from the recruited 222 patients were collected. Quantitative real-time polymerase chain reaction (qRT-PCR), Western blotting and immunohistochemistry were applied to determine the expressions of FoxO3 and FoxO4...
April 20, 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28540249/liquid-biopsies-for-bladder-cancer
#19
EDITORIAL
Douglas G Ward, Richard T Bryan
The development of accurate urinary biomarkers for the non-invasive detection of urothelial bladder cancer (UBC) could transform patient pathways by reducing reliance on cystoscopy, and the identification of highly prognostic (or even predictive) biomarkers could better guide patient management. A number of approaches are being utilised to address these challenges in both urinary- and plasma-borne tumour DNA (tDNA), so-called "liquid biopsies". Next generation sequencing (NGS) and droplet digital PCR (ddPCR) allow detection of very low levels of such tDNA amongst a large excess of non-tumour DNA, the former permitting large mutation panels to be assessed and the latter potentially identifying ultrarare mutant alleles yet restricted for multiplexing...
April 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28533583/high-grade-urothelial-carcinoma-of-bladder-transforming-to-micropapillary-variant-on-follow-up
#20
Nitu Kumari, Anupama Jha, Pawan Vasudeva, Usha Agrawal
Micropapillary variant of urothelial carcinoma (UC) of the bladder is an aggressive tumour, comprising 0.6-6% of all UC. It generally presents with high-grade and stage, and has been reported as having a worse prognosis when compared to traditional UC. We report the case of a 58-year-old man who presented with macroscopic haematuria. The patient was diagnosed with high-grade urothelial carcinoma and returned with recurrence after 16 months. Histopathology after transurethral biopsy revealed a non-muscle invasive high-grade bladder tumour at first presentation, whereas tumour recurrence was reported after 1...
May 2017: Iranian Journal of Medical Sciences
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