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High grade non muscle invasive bladder cancer

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https://www.readbyqxmd.com/read/27908636/impact-of-neoadjuvant-chemotherapy-on-complications-of-minimally-invasive-radical-cystectomy
#1
D Lizée, R S Salas, E Barret, M Galiano, E Di Trapani, F Montorsi, X Cathelineau
BACKGROUND: Neoadjuvant chemotherapy (NC) before minimally invasive radical cystectomy (MIRC) is considered a standard of care in muscle-invasive bladder cancer or recurrent high-risk non-muscle-invasive bladder cancer. OBJECTIVE: To evaluate the impact of NC on morbidity and mortality after MIRC. DESIGN, SETTING, AND PARTICIPANTS: We prospectively evaluated 135 patients who underwent MIRC (laparoscopic: n=100; robotic: n=35) between 2007 and 2013 with ≥90 days of follow-up (median age: 66 year)...
November 28, 2016: Actas Urologicas Españolas
https://www.readbyqxmd.com/read/27908634/systematic-review-of-perioperative-outcomes-and-complications-after-open-laparoscopic-and-robot-assisted-radical-cystectomy
#2
A Palazzetti, R Sanchez-Salas, P Capogrosso, E Barret, N Cathala, A Mombet, D Prapotnich, M Galiano, F Rozet, X Cathelineau
Radical cystectomy and regional lymph node dissection is the standard treatment for localized muscle-invasive and for high-risk non-muscle-invasive bladder cancer, and represents one of the main surgical urologic procedures. The open surgical approach is still widely adopted, even if in the last two decades efforts have been made in order to evaluate if minimally invasive procedures, either laparoscopic or robot-assisted, might show a benefit compared to the standard technique. Open radical cystectomy is associated with a high complication rate, but data from the laparoscopic and robotic surgical series failed to demonstrate a clear reduction in post-operative complication rates compared to the open surgical series...
November 28, 2016: Actas Urologicas Españolas
https://www.readbyqxmd.com/read/27902773/genomic-landscape-of-experimental-bladder-cancer-in-rodents-and-its-application-to-human-bladder-cancer-gene-amplification-and-potential-overexpression-of-cyp2a5-cyp2a6-are-associated-with-the-invasive-phenotype
#3
Kazuhiro Kanemoto, Katsuhiro Fukuta, Noriyasu Kawai, Keiichi Tozawa, Masako Ochiai, Koji Okamoto, Sumiko Ohnami, Hiromi Sakamoto, Teruhiko Yoshida, Yae Kanai, Masaru Katoh, Takahiro Yasui, Kenjiro Kohri, Tadao Kakizoe, Hitoshi Nakagama
Non-muscle invasive (superficial) bladder cancer is a low-grade malignancy with good prognosis, while muscle invasive (invasive) bladder cancer is a high-grade malignancy with poor prognosis. N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) induces superficial bladder cancers with papillary morphology in rats and invasive bladder cancers with infiltrating phenotype in mice. In this study, we analyzed genomic landscapes of rodent BBN-induced bladder cancers using array-based comparative genomic hybridization (array CGH)...
2016: PloS One
https://www.readbyqxmd.com/read/27895377/frequency-and-predictors-of-recurrence-of-bladder-tumour-on-first-check-cystoscopy-a-tertiary-care-hospital-experience
#4
Muhammad Farhan, Syed Muhammad Nazim, Jibran Ahmed, Muhammad Hammad Ather
OBJECTIVE: To determine the frequency and predictors of non-muscle invasive bladder tumour recurrence on first-check cystoscopy after transurethral resection of bladder tumour. METHODS: This cross-sectional study was conducted at the Aga Khan University Hospital, Karachi, from April to November 2014, and comprised patients with a suspected newly-diagnosed urothelial cancer. Patients with non-muscle invasive disease with complete resection of all visible lesions along with deep biopsy from the tumour base were included...
October 2016: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/27769244/natural-killer-cell-based-adoptive-immunotherapy-eradicates-and-drives-differentiation-of-chemoresistant-bladder-cancer-stem-like-cells
#5
Margarida Ferreira-Teixeira, Daniela Paiva-Oliveira, Belmiro Parada, Vera Alves, Vitor Sousa, Obinna Chijioke, Christian Münz, Flávio Reis, Paulo Rodrigues-Santos, Célia Gomes
BACKGROUND: High-grade non-muscle invasive bladder cancer (NMIBC) has a high risk of recurrence and progression to muscle-invasive forms, which seems to be largely related to the presence of tumorigenic stem-like cell populations that are refractory to conventional therapies. Here, we evaluated the therapeutic potential of Natural Killer (NK) cell-based adoptive immunotherapy against chemoresistant bladder cancer stem-like cells (CSCs) in a pre-clinical relevant model, using NK cells from healthy donors and NMIBC patients...
October 21, 2016: BMC Medicine
https://www.readbyqxmd.com/read/27766490/impact-of-smoking-status-and-cumulative-smoking-exposure-on-tumor-recurrence-of-non-muscle-invasive-bladder-cancer
#6
Hao Min Li, Baihetiya Azhati, Mulati Rexiati, Wen Guang Wang, Xiao Dong Li, Qiang Liu, Yu-Jie Wang
OBJECTIVE: To investigate the effect of smoking status, cumulative smoking exposure and smoking cessation on the outcomes of patient with non-muscle-invasive bladder cancer (NMIBC). METHODS: We collected smoking data from 484 patients with NMIBC who were treated with transurethral resection (TUR); smoking status was categorized as (never smokers vs current smokers vs former smokers). Cumulative smoking exposure was categorized as high smoking exposure (cigarette index ≥400) versus low smoking exposure (cigarette index <400)...
October 20, 2016: International Urology and Nephrology
https://www.readbyqxmd.com/read/27744487/clinical-outcomes-of-second-transurethral-resection-in-non-muscle-invasive-high-grade-bladder-cancer-a-retrospective-multi-institutional-collaborative-study
#7
Naoto Kamiya, Hiroyoshi Suzuki, Takahito Suyama, Masayuki Kobayashi, Satoshi Fukasawa, Nobuyuki Sekita, Kazuo Mikami, Naoki Nihei, Yukio Naya, Tomohiko Ichikawa
BACKGROUND: A retrospective, multi-institutional collaborative study was conducted to evaluate the impact of second transurethral resection (TUR) on the clinical outcome of non-muscle invasive high-grade bladder cancer and to identify predictors of invasion to the lamina propria (pT1) or deeper and residual tumor at the second TUR. METHODS: The clinical and pathological features of 198 patients with non-muscle invasive high-grade bladder cancer treated in five medical institutions from April 1990 to March 2013 were reviewed retrospectively...
October 15, 2016: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27717367/a-multiplex-urinary-immunoassay-for-bladder-cancer-detection-analysis-of-a-japanese-cohort
#8
Steve Goodison, Osamu Ogawa, Yoshiyuki Matsui, Takashi Kobayashi, Makito Miyake, Sayuri Ohnishi, Kiyohide Fujimoto, Yunfeng Dai, Yoshiko Shimizu, Kazue Tsukikawa, Hideki Furuya, Charles J Rosser
BACKGROUND: Bladder cancer (BCa) is among the most commonly diagnosed malignancies worldwide, and due the high rate of post-operative disease recurrence, it is one of the most prevalent in many countries. The development of non-invasive molecular assays that can accurately detect and monitor BCa would be a major advance, benefiting both patients and healthcare systems. We have previously identified a urinary protein biomarker panel that is being developed for application in at-risk patient cohorts...
October 7, 2016: Journal of Translational Medicine
https://www.readbyqxmd.com/read/27701987/efficacy-and-safety-of-bladder-hydrodistension-for-decreased-bladder-capacity-induced-by-intravesical-bcg-therapy
#9
Kazuyuki Numakura, Norihiko Tsuchiya, Hiroshi Tsuruta, Susumu Akihama, Mitsuru Saito, Takamitsu Inoue, Shintaro Narita, Mingguo Huang, Shigeru Satoh, Tomonori Habuchi
OBJECTIVE: Intravesical BCG therapy is widely used for the treatment of high-risk, non-muscle-invasive bladder cancer. Among various reported side-effects, decreased bladder capacity is a serious side-effect that significantly worsens patients' quality of life. This article reports the efficacy and safety of bladder hydrodistension (BHD) in six patients with seriously decreased bladder capacity caused by BCG treatment. METHODS: Six patients with low bladder capacity (<100 ml in voiding diaries) and complaint of grade 3 irritative symptoms were diagnosed with decreased bladder capacity and treated with BHD...
October 5, 2016: Scandinavian Journal of Urology
https://www.readbyqxmd.com/read/27644257/downregulation-of-pigment-epithelium-derived-factor-is-associated-with-increased-epithelial-mesenchymal-transition-emt-in-bladder-cancer
#10
Bin B Dong, Jia S Yan, Yang Y Yan, Tian C Xie, Liang Xu, Guang H Hu, Yun F Xu, Min Liu
BACKGROUND: Pigment epithelium-derived factor (PEDF) has been reported to inhibit angiogenesis in bladder cancer, but whether it modulates epithelial-mesenchymal transition (EMT) remains unknown. METHODS: We have included 68 samples of non-muscle invasive bladder cancer in this study. Immunohistochemistry was performed in all sample sections for expressions of PEDF, SNAI2, Vimentin and E-cadherin, which were quantified and The EMT index (EMTi) was calculated by Vimentin/E-cadherin...
September 20, 2016: Panminerva Medica
https://www.readbyqxmd.com/read/27639776/the-efficacy-of-bcg-tice-and-bcg-connaught-in-a-cohort-of-2-099-patients-with-t1g3-non-muscle-invasive-bladder-cancer
#11
J Alfred Witjes, Guido Dalbagni, Robert J Karnes, Shahrokh Shariat, Steven Joniau, Joan Palou, Vincenzo Serretta, Stéphane Larré, Savino di Stasi, Renzo Colombo, Marek Babjuk, Per-Uno Malmström, Nuria Malats, Jacques Irani, Jack Baniel, Tommaso Cai, Eugene Cha, Peter Ardelt, John Varkarakis, Riccardo Bartoletti, Martin Spahn, Francesca Pisano, Paolo Gontero, Richard Sylvester
BACKGROUND: Potential differences in efficacy of different bacillus Calmette-Guérin (BCG) strains are of importance for daily practice, especially in the era of BCG shortage. OBJECTIVE: To retrospectively compare the outcome with BCG Connaught and BCG TICE in a large study cohort of pT1 high-grade non-muscle-invasive bladder cancer patients. DESIGN, SETTING, AND PARTICIPANTS: Individual patient data were collected for 2,451 patients with primary T1G3 tumors from 23 centers who were treated with BCG for the first time between 1990 and 2011...
September 14, 2016: Urologic Oncology
https://www.readbyqxmd.com/read/27637323/cell-cycle-markers-do-not-improve-discrimination-of-eortc-and-cueto-risk-models-in-predicting-recurrence-and-progression-of-non-muscle-invasive-high-grade-bladder-cancer
#12
Niccolo Passoni, Bishoy Gayed, Payal Kapur, Arthur I Sagalowsky, Shahrokh F Shariat, Yair Lotan
PURPOSE: To assess if a panel of cell-cycle markers could improve the discrimination of European Organization for Research and Treatment of Cancer (EORTC) and Spanish Urological Club for Oncological Treatment (CUETO) models in predicting recurrence and progression of high-grade non-muscle-invasive bladder cancer (NMIBC). MATERIALS AND METHODS: Between January 2007 and January 2012, every patient with high-grade NMIBC treated with transurethral resection of bladder underwent immunohistochemical staining for 5 biomarkers (p21, p27, p53, KI-67, and cyclin E1)...
September 13, 2016: Urologic Oncology
https://www.readbyqxmd.com/read/27611947/detection-of-multiple-mutations-in-urinary-exfoliated-cells-from-male-bladder-cancer-patients-at-diagnosis-and-during-follow-up
#13
Rossana Critelli, Francesca Fasanelli, Marco Oderda, Silvia Polidoro, Manuela Bianca Assumma, Clara Viberti, Mirko Preto, Paolo Gontero, Giuseppina Cucchiarale, Irene Lurkin, Ellen C Zwarthoff, Paolo Vineis, Carlotta Sacerdote, Giuseppe Matullo, Alessio Naccarati
Most bladder cancer (BC) patients need life-long, invasive and expensive monitoring and treatment, making it a serious burden on the health system. Thus, there is a pressing need for an accurate test to assist diagnosis and surveillance of BC as an alternative to cystoscopy. Mutations in human TERT, FGFR3, PIK3CA, and RAS genes have been proposed as potential molecular markers in bladder tumor. Their concomitant presence in urine samples has not been fully explored.We investigated a panel of mutations in DNA from exfoliated urinary cells of 255 BC patients at diagnosis...
September 7, 2016: Oncotarget
https://www.readbyqxmd.com/read/27599396/clinical-significance-of-cd44-variant-9-expression-as-a-prognostic-indicator-in-bladder-cancer
#14
Keita Kobayashi, Hiroaki Matsumoto, Hideyasu Matsuyama, Nakanori Fujii, Ryo Inoue, Yoshiaki Yamamoto, Kazuhiro Nagao
CD44, a major surface receptor for hyaluronic acid, has multiple isoforms and represents a major cancer stem cell marker for various epithelial tumors. CD44 variant 9 (CD44v9) was correlated with recurrence and metastasis in gastric and colon cancer. We examined its role in invasion and as a biomarker for the basal muscle invasive molecular subtype showing worse prognosis, and for tumor progression in high risk (pT1/high grade) non‑muscle invasive bladder cancers (NMIBCs). CD44v9, cytokeratin 5/6 (CK5/6), and cytokeratin 20 (CK20) expression was evaluated by immunohistochemistry in 98 pathologically confirmed specimens (36 muscle and 62 high‑risk non‑muscle) and correlated to clinical outcome...
September 1, 2016: Oncology Reports
https://www.readbyqxmd.com/read/27578166/clinical-significance-of-cdh13-promoter-methylation-as-a-biomarker-for-bladder-cancer-a-meta-analysis
#15
Feng Chen, Tao Huang, Yu Ren, Junjun Wei, Zhongguan Lou, Xue Wang, Xiaoxiao Fan, Yirun Chen, Guobin Weng, Xuping Yao
BACKGROUND: Methylation of the tumor suppressor gene H-cadherin (CDH13) has been reported in many cancers. However, the clinical effect of the CDH13 methylation status of patients with bladder cancer remains to be clarified. METHODS: A systematic literature search was performed to identify eligible studies in the PubMed, Embase, EBSCO, CKNI and Wanfang databases. The pooled odds ratio (OR) and the corresponding 95 % confidence interval (95 % CI) was calculated and summarized...
2016: BMC Urology
https://www.readbyqxmd.com/read/27530957/analysis-of-papillary-urothelial-carcinomas-of-the-bladder-with-grade-heterogeneity-supportive-evidence-for-an-early-role-of-cdkn2a-deletions-in-the-fgfr3-pathway
#16
Michelle R Downes, Berber Weening, Bas W G van Rhijn, Cherry L Have, Kilian M Treurniet, Theodorus H van der Kwast
AIMS: The dual pathway model of urothelial carcinogenesis does not fully explain grade and stage progression in patients with initial low grade, non-muscle invasive urothelial carcinomas. FGFR3 mutations are a hallmark of the low grade pathway, with subsequent progression to muscle invasion occurring when FGFR3 mutant tumours exhibit a homozygous CDKN2A deletion. We hypothesized that grade heterogeneity represents the morphologic manifestation of molecular changes associated with disease progression...
August 17, 2016: Histopathology
https://www.readbyqxmd.com/read/27509372/external-validation-of-eortc-risk-scores-to-predict-recurrence-after-transurethral-resection-of-brazilian-patients-with-non-muscle-invasive-bladder-cancer-stages-ta-and-t1
#17
Gilberto L Almeida, Wilson F S Busato, Carmen Marcondes Ribas, Jurandir Marcondes Ribas, Ottavio De Cobelli
: Validate the EORTC risk tables in Brazilian patients with NMIBC. METHODS: 205 patients were analyzed. The 6 parameters analyzed were: histologic grading, pathologic stage, size and number of tumors, previous recurrence rate and concomitant CIS. The time for first recurrence (TFR), risk score and probability of re¬currence were calculated and compared to the probabilities obtained from EORTC risk tables. C-index was calculated and accuracy of EORTC tables was analyzed...
August 10, 2016: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/27492610/high-risk-non-muscle-invasive-bladder-cancer-therapy-options-during-intravesical-bcg%C3%A2-shortage
#18
REVIEW
Rajan Veeratterapillay, Rakesh Heer, Mark I Johnson, Raj Persad, Christian Bach
Bladder cancer is the second commonest urinary tract malignancy with 70-80 % being non-muscle invasive (NMIBC) at diagnosis. Patients with high-risk NMIBC (T1/Tis, with high grade/G3, or CIS) represent a challenging group as they are at greater risk of recurrence and progression. Intravesical Bacilli Calmette-Guerin (BCG) is commonly used as first line therapy in this patient group but there is a current worldwide shortage. BCG has been shown to reduce recurrence in high-risk NMIBC and is more effective that other intravesical agents including mitomycin C, epirubicin, interferon-alpha and gemcitabine...
September 2016: Current Urology Reports
https://www.readbyqxmd.com/read/27477528/oncologic-outcomes-of-kidney-sparing-surgery-versus-radical-nephroureterectomy-for-upper-tract-urothelial-carcinoma-a-systematic-review-by-the-eau-non-muscle-invasive-bladder-cancer-guidelines-panel
#19
Thomas Seisen, Benoit Peyronnet, Jose Luis Dominguez-Escrig, Harman M Bruins, Cathy Yuhong Yuan, Marko Babjuk, Andreas Böhle, Maximilian Burger, Eva M Compérat, Nigel C Cowan, Eero Kaasinen, Joan Palou, Bas W G van Rhijn, Richard J Sylvester, Richard Zigeuner, Shahrokh F Shariat, Morgan Rouprêt
CONTEXT: There is uncertainty regarding the oncologic effectiveness of kidney-sparing surgery (KSS) compared with radical nephroureterectomy (RNU) for upper tract urothelial carcinoma (UTUC). OBJECTIVE: To systematically review the current literature comparing oncologic outcomes of KSS versus RNU for UTUC. EVIDENCE ACQUISITION: A computerised bibliographic search of the Medline, Embase, and Cochrane databases was performed for all studies reporting comparative oncologic outcomes of KSS versus RNU...
July 28, 2016: European Urology
https://www.readbyqxmd.com/read/27460088/overexpression-of-long-non-coding-rna-tug1-predicts-poor-prognosis-and-promotes-cancer-cell-proliferation-and-migration-in-high-grade-muscle-invasive-bladder-cancer
#20
Robert Iliev, Renata Kleinova, Jaroslav Juracek, Jan Dolezel, Zuzana Ozanova, Michal Fedorko, Dalibor Pacik, Marek Svoboda, Michal Stanik, Ondrej Slaby
Long non-coding RNA TUG1 is involved in the development and progression of a variety of tumors. Little is known about TUG1 function in high-grade muscle-invasive bladder cancer (MIBC). The aims of our study were to determine expression levels of long non-coding RNA TUG1 in tumor tissue, to evaluate its relationship with clinico-pathological features of high-grade MIBC, and to describe its function in MIBC cells in vitro. TUG1 expression levels were determined in paired tumor and adjacent non-tumor bladder tissues of 47 patients with high-grade MIBC using real-time PCR...
July 27, 2016: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
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