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High grade non muscle invasive bladder cancer

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https://www.readbyqxmd.com/read/29754838/-bcg-infection-following-intravesicular-immunotherapy-for-bladder-cancer
#1
REVIEW
L Levi, M Groh, N De Castro, A Bergeron, F Schlemmer
BACKGROUND: Bacille of Calmette et Guérin (BCG) immunotherapy is the most effective treatment for non-muscle-invasive bladder cancer. Yet, potentially severe localized or systemic mycobacterial infections can happen. STATE OF KNOWLEDGE: In a patient who underwent BCG instillation for bladder cancer, the diagnosis of BCG infection is usually suggested by more than 3 days of high-grade fever and systemic and/or local symptoms with no other plausible alternative diagnosis...
May 10, 2018: Revue des Maladies Respiratoires
https://www.readbyqxmd.com/read/29753491/comparison-of-the-diagnostic-value-of-monoexponential-biexponential-and-stretched-exponential-diffusion-weighted-mri-in-differentiating-tumor-stage-and-histological-grade-of-bladder-cancer
#2
Yanchun Wang, Daoyu Hu, Hao Yu, Yaqi Shen, Hao Tang, Ihab R Kamel, Zhen Li
RATIONALE AND OBJECTIVES: We aimed to determine the utility of various diffusion parameters obtained from monoexponential, biexponential, and stretched exponential diffusion-weighted imaging (DWI) models in differentiating tumor stage and grade of bladder cancer. MATERIALS AND METHODS: Forty-five patients with pathologically confirmed bladder cancer underwent multi-b-value DWI. An apparent diffusion coefficient (ADC) was calculated from DWI by using a monoexponential model...
May 9, 2018: Academic Radiology
https://www.readbyqxmd.com/read/29745932/analysis-of-tolerance-and-security-of-chemo-hyperthermia-with-mitomycin-c-for-the-treatment-of-non-muscle-invasive-bladder-cancer
#3
Juan León-Mata, José Luis Domínguez, Joan Palou Redorta, Daniel Sousa González, María Alvarez Casal, Alejandro Sousa Escandón, Eva Piñeiro Vázquez
OBJECTIVES: The treatment of non muscle invasive bladder cancer (NMIBC) continues to be a challenge. Hyperthermia (HT) combined with intravesical chemotherapy is used to enhance the effects of chemotherapy. METHODS: A review of the publications was carried out to synthesize the adverse effects (AE) reported by the use of chemohyperthermia (QHT) with Mitomycin-C (MMC). The most relevant data are exposed for each of the devices currently used in the QHT. RESULTS: SYNERGO®: The dropout rate varied between 3-40%, and the AE rate is up to 88%...
May 2018: Archivos Españoles de Urología
https://www.readbyqxmd.com/read/29731899/expression-of-cd74-in-bladder-cancer-and-its-suppression-in-association-with-cancer-proliferation-invasion-and-angiogenesis-in-ht-1376-cells
#4
Jun-Wei Gai, Wasilijiang Wahafu, Liming Song, Hao Ping, Mingshuai Wang, Feiya Yang, Yinong Niu, Wei Qing, Nianzeng Xing
The aim of the present study was to investigate the expression and potential roles of CD74 in human urothelial cell carcinoma of the bladder (UCB) in vitro and in vivo . CD74 and macrophage migration inhibitory factor (MIF) were located and assayed in normal and UCB samples and cell lines using immunostaining. CD74 was knocked down using CD74 shRNA lentiviral particles in HT-1376 cells. The proliferative, invasive potential and microvessel density (MVD) of knockdown-CD74 HT-1376 cells were analyzed in vitro or in vivo ...
May 2018: Oncology Letters
https://www.readbyqxmd.com/read/29699838/perioperative-and-mid-term-oncologic-outcomes-of-robotic-assisted-radical-cystectomy-with-totally-intracorporeal-neobladder-results-of-a-propensity-score-matched-comparison-with-open-cohort-from-a-single-centre-series
#5
Giuseppe Simone, Gabriele Tuderti, Leonardo Misuraca, Umberto Anceschi, Mariaconsiglia Ferriero, Francesco Minisola, Salvatore Guaglianone, Michele Gallucci
AIM: In this study, we compared perioperative and oncologic outcomes of patients treated with either open or robot-assisted radical cystectomy and intracorporeal neobladder at a tertiary care center. METHODS: The institutional prospective bladder cancer database was queried for "cystectomy with curative intent" and "neobladder". All patients underwent robot-assisted radical cystectomy and intracorporeal neobladder or open radical cystectomy and orthotopic neobladder for high-grade non-muscle invasive bladder cancer or muscle invasive bladder cancer with a follow-up length ≥2 years were included...
April 17, 2018: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29677897/re-intravesical-rad-ifn%C3%AE-syn3-for-patients-with-high-grade-bacillus-calmette-guerin-refractory-or-relapsed-non-muscle-invasive-bladder-cancer-a-phase-ii-randomized-study
#6
https://www.readbyqxmd.com/read/29674052/glycan-affinity-magnetic-nanoplatforms-for-urinary-glycobiomarkers-discovery-in-bladder-cancer
#7
Rita Azevedo, Janine Soares, Cristiana Gaiteiro, Andreia Peixoto, Luís Lima, Dylan Ferreira, Marta Relvas-Santos, Elisabete Fernandes, Ana Tavares, Sofia Cotton, Ana Luísa Daniel-da-Silva, Lúcio Lara Santos, Rui Vitorino, Francisco Amado, José Alexandre Ferreira
Bladder Cancer (BC) presents one of the highest recurrence rates amongst solid tumours and constitutes the second deadliest disease of the genitourinary track. Non-invasive identification of patients facing disease recurrence and/or progression remains one of the most critical and challenging aspects in disease management. To contribute to this goal, we demonstrate the potential of glycan-affinity glycoproteomics nanoplatforms for urinary biomarkers discovery in bladder cancer. Briefly, magnetic nanoprobes (MNP) coated with three broad-spectrum lectins, namely Concanavalin A (ConA; MNP@ConA), Wheat Germ Agglutinin (WGA; MNP@WGA), and Sambucus nigra (SNA; MNP@SNA), were used to selectively capture glycoproteins from the urine of low-grade and high-grade non-muscle invasive as well as muscle-invasive BC patients...
July 1, 2018: Talanta
https://www.readbyqxmd.com/read/29629867/recurrence-and-upstaging-rates-of-t1-high-grade-urothelial-carcinoma-of-the-bladder-on-repeat-resection-in-a-canadian-resource-limited-healthcare-system
#8
Adam Kinnaird, Peter Dromparis, Howard Evans
INTRODUCTION: Non-muscle-invasive bladder cancer is the most expensive malignancy to treat. Current Canadian guidelines recommend repeat transurethral resection of bladder tumour (TURBT) within six weeks after initial resection of T1 high-grade (T1HG) urothelial carcinoma, prior to initiation of intravesical bacillus Calmette-Guerin treatment. This is a burden on operating room usage and adds further cost and risk of complications. Internationally, major cancer centres report significant rates of recurrence and upstaging on repeat resection, however minimal Canadian data is available...
April 6, 2018: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/29607745/outpatient-diode-laser-treatment-of-intermediate-risk-non-invasive-bladder-tumors-without-sedation-efficacy-safety-and-economic-analysis
#9
Gregers Gautier Hermann, Karin Mogensen, Susanne Rosthøj
OBJECTIVE: This study aimed to validate a new method for outpatient diode laser ablation of bladder tumors without sedation or pain control. METHODS: Twenty-one patients with stage Ta low-grade intermediate-risk bladder tumors underwent photodynamic-guided laser ablation of their bladder tumors and 1 month later follow-up cystoscopy with photodynamic and IMAGE1 S™-guided biopsies. Pain was measured using a visual analog scale (range 0-10). Symptoms and worries about the future disease course were calculated using the Quality of Life Questionnaire for Non-Muscle-Invasive Bladder Cancer (range 0-100, high scores indicating worse symptoms or worry)...
April 1, 2018: Scandinavian Journal of Urology
https://www.readbyqxmd.com/read/29592878/nuclear-factor-%C3%AE%C2%BAb-promotes-urothelial-tumorigenesis-and-cancer-progression-via-cooperation-with-androgen-receptor-signaling
#10
Satoshi Inoue, Hiroki Ide, Taichi Mizushima, Guiyang Jiang, George J Netto, Momokazu Gotoh, Hiroshi Miyamoto
We investigated the role of NF-κB in the development and progression of urothelial cancer as well as cross-talk between NF-κB and androgen receptor (AR) signals in urothelial cells. Immunohistochemistry in surgical specimens showed that the expression levels of NF-κB/p65 (P=0.015)/phospho-NF-κB/p65 (P<0.001) were significantly elevated in bladder tumors, compared with those in non-neoplastic urothelial tissues. The rates of phospho-NF-κB/p65 positivity were also significantly higher in high-grade (P=0...
March 28, 2018: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/29577063/association-between-metabolic-syndrome-and-recurrence-of-nonmuscle-invasive-bladder-cancer-following-bacillus-calmette-gu%C3%A3-rin-treatment
#11
Andrew T Lenis, Kian Asanad, Maher Blaibel, Nicholas M Donin, Karim Chamie
Introduction: Intravesical bacillus Calmette-Guérin (BCG) therapy is the gold standard adjuvant treatment for patients with high-grade non-muscle-invasive bladder cancer (NMIBC). Despite the association between metabolic syndrome (MetS) and bladder cancer, the association between MetS and BCG failure is unknown. The objective of this study was to characterize disease recurrence following BCG in patients with and without MetS. Methods: We retrospectively evaluated the records of patients undergoing TURBT at our institution in 2012-2015 for NMIBC and identified those who received adjuvant BCG therapy...
March 2018: Urology Practice
https://www.readbyqxmd.com/read/29573965/the-evolution-of-bladder-cancer-genomics-what-have-we-learned-and-how-can-we-use-it
#12
REVIEW
François Audenet, Kyrollis Attalla, John P Sfakianos
BACKGROUND: With advancements in molecular biology techniques, great progress has been made in the understanding of urothelial carcinoma pathogenesis. OBJECTIVE: To examine the historic description of molecular alterations in bladder cancer and their evolution towards our current comprehension of the biology of the disease. RESULTS: Historically, a two-pathway model was described from histological and cytogenetic studies: low-grade papillary non-muscle invasive bladder cancers (NMIBC) were described to arise from epithelial hyperplasia with loss of chromosome 9 as an early event, whereas muscle-invasive bladder cancers (MIBC) were considered to develop from dysplasia, associated with genetic instability...
March 21, 2018: Urologic Oncology
https://www.readbyqxmd.com/read/29570711/smoking-intensity-and-bladder-cancer-aggressiveness-at-diagnosis
#13
André L A Barbosa, Sita H H M Vermeulen, Katja K Aben, Anne J Grotenhuis, Alina Vrieling, Lambertus A Kiemeney
OBJECTIVE: To explore the relation between cigarette smoking intensity and bladder cancer aggressiveness at first diagnosis. METHODS: Patients diagnosed with urinary bladder cancer (BC) between 1995-2011 under the age of 75 years were retrospectively identified from the Netherlands Cancer Registry and invited for a study on genetic and lifestyle risk factors for BC. Information on patients' self-reported smoking history was retrieved by means of a postal questionnaire...
2018: PloS One
https://www.readbyqxmd.com/read/29525824/snail-immunohistochemical-overexpression-correlates-to-recurrence-risk-in-non-muscle-invasive-bladder-cancer-results-from-a-longitudinal-cohort-study
#14
Raffaella Santi, Tommaso Cai, Stefania Nobili, Ilaria Camilla Galli, Andrea Amorosi, Eva Comperat, Gabriella Nesi
The current WHO/ISUP classification and grading system subdivides urothelial tumours into prognostically distinct categories. Understanding the molecular pathways involved in bladder cancer development can improve patient stratification and management. This study aims to investigate the relationship between Snail, Slug and E-cadherin expressions and clinico-pathological features of non-muscle invasive bladder carcinoma (NMIBC). All patients attending the same urological centre from January to May 2002, who were pathologically diagnosed with NMIBC, were enrolled in this longitudinal cohort study...
April 2018: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/29523366/repeat-transurethral-resection-in-non-muscle-invasive-bladder-cancer-a-systematic-review
#15
REVIEW
Marcus G K Cumberbatch, Beat Foerster, James W F Catto, Ashish M Kamat, Wassim Kassouf, Ibrahim Jubber, Shahrokh F Shariat, Richard J Sylvester, Paolo Gontero
CONTEXT: Initial treatment for most bladder cancers (BCs) involves transurethral resection (TUR) or tumours. Often more cancer is found after the initial treatment in around half of patients, requiring a second resection. Repeat transurethral resection (reTUR) is recommended for high-risk, non-muscle-invasive bladder cancer (NMIBC) to remove any residual disease and improve cancer outcomes. OBJECTIVE: To systematically review the practice and therapeutic benefit of an early reTUR for high-risk NMIBC...
June 2018: European Urology
https://www.readbyqxmd.com/read/29480994/impact-of-cyclin-d1-and-heterogeneous-nuclear-ribonucleoprotein-k-hnrnp-k-on-urinary-bladder-carcinogenesis
#16
Tarek Aboushousha, Olfat Hammam, Noha Helal, Samir El Dahshan
Objective: This study aimed to investigate the expression of cyclin D1 and hnRNP-K in relation to the pathological findings in bladder cancer including the type, grade, muscle invasion and bilharzial association. Methods: We studied the immunoexpression; as regard the percentage, intensity and score of both cyclin D1 and hnRNP-K in different bladder lesions including 10 cases of cystitis; 10 cases of carcinoma insitu (CIS), 20 cases of Squamous cell carcinoma (SCC) and 66 cases of urothelial carcinoma (UC)...
February 26, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/29478198/transurethral-en-bloc-resection-with-bipolar-button-electrode-for-non-muscle-invasive-bladder-cancer
#17
Junfeng Zhang, Longsheng Wang, Shiyu Mao, Mengnan Liu, Wentao Zhang, Ziwei Zhang, Yadong Guo, Bisheng Huang, Yang Yan, Yong Huang, Xudong Yao
PURPOSE: Transurethral resection of bladder tumor (TURBT) using a wire loop is considered the gold standard for staging and treating non-muscle invasive bladder cancer (NMIBC). TURBT is associated with serious disadvantages that facilitate tumor recurrence. The present study evaluated the safety and efficacy of the bipolar button electrode for en bloc resection of NMIBC. METHODS: From January 2013 to July 2016, 82 consecutive patients newly diagnosed with NMIBC received transurethral en bloc resection with bipolar button electrode...
April 2018: International Urology and Nephrology
https://www.readbyqxmd.com/read/29473376/can-re-cturbt-be-useful-in-pt1hg-disease-as-a-risk-indicator-of-recurrence-and-progression-a-single-centre-experience
#18
Roberto Giulianelli, Barbara Cristina Gentile, Gabriella Mirabile, Luca Albanesi, Paola Tariciotti, Giorgio Rizzo, Maurizio Buscarini, Mauro Vermiglio
INTRODUCTION: Understaging after initial transurethral resection is common in patients with high-risk non muscle infiltrating bladder cancer (NMIBC) and can delay accurate diagnosis and definitive treatment. The rate of upstaging from T1 to T2 disease after repeated transurethral resection ranges from 0 to 28%, although the rate of upstaging may be even higher up to 49% when muscularis propria is absent in the first specimen. A restaging classic transurethral resection of bladder tumour (re-cTURBT) is the better predictor of early stage progression...
December 31, 2017: Archivio Italiano di Urologia, Andrologia
https://www.readbyqxmd.com/read/29473226/infiltrative-lamina-propria-invasion-pattern-as-an-independent-predictor-for-cancer-specific-and-overall-survival-of-instillation-treatment-na%C3%A3-ve-stage-t1-high-grade-urothelial-bladder-cancer
#19
Wolfgang Otto, Bas Wg van Rhijn, Johannes Breyer, Simone Bertz, Markus Eckstein, Roman Mayr, Eva M Lausenmeyer, Stefan Denzinger, Maximilian Burger, Arndt Hartmann
OBJECTIVES: To investigate established prognostic factors and relatively new histopathological tumor characteristics including metric substage and lamina propria invasion patterns in a large series of T1 high-grade non-muscle-invasive bladder cancer. METHODS: Between 1989 and 2012, 322 patients with initial stage T1 high-grade bladder cancer underwent transurethral resection, followed by re-transurethral resection and a conservative approach with follow-up regime alone or instillation treatment...
May 2018: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/29434875/soluble-her3-predicts-survival-in-bladder-cancer-patients
#20
Ashfaque A Memon, Stephen C Gilliver, Michael Borre, Jan Sundquist, Kristina Sundquist, Ebba Nexo, Boe S Sorensen
The role of soluble human epidermal growth factor receptor (sHER3) in bladder cancer remains unclear. In the present study, an ELISA was developed for the quantification of sHER3 and its role was investigated in patients with bladder cancer (n=82) followed for 10 years. Furthermore, the effects of sHER3 on bladder cancer cell growth and migration were also investigated. The results demonstrated that plasma sHER3 levels were significantly higher in non-invasive tumours (Ta) compared with muscle-invasive tumours (T2-T4)...
February 2018: Oncology Letters
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