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https://www.readbyqxmd.com/read/28922103/budd-chiari-syndrome
#1
Tomáš Grus, Lukáš Lambert, Gabriela Grusová, Rohan Banerjee, Andrea Burgetová
Budd-Chiari syndrome (BCS) is a rare disease with an incidence of 0.1 to 10 per million inhabitants a year caused by impaired venous outflow from the liver mostly at the level of hepatic veins and inferior vena cava. Etiological factors include hypercoagulable conditions, myeloprolipherative diseases, anatomical variability of the inferior vena cava, and environmental conditions. Survival rates in treated patients range from 42 to 100% depending on the etiology and the presence of risk factors including parameters of Child-Pugh score, sodium and creatinine plasma levels, and the choice of treatment...
2017: Prague Medical Report
https://www.readbyqxmd.com/read/28920172/hepatocellular-carcinoma-screening-utilising-serum-alpha-fetoprotein-measurement-and-abdominal-ultrasound-is-more-effective-than-ultrasound-alone-in-patients-with-non-viral-cirrhosis
#2
Thomas Worland, Benjamin Harrison, Leighton Delmenico, Damian Dowling
PURPOSE: This study is aimed to determine the performance of alpha-fetoprotein (AFP) as part of hepatocellular carcinoma (HCC) screening in a non-viral cirrhosis population. METHODS: A retrospective audit was conducted of patients with non-viral cirrhosis over a 13 year period managed at a single centre. All patients were investigated routinely for evidence of viral hepatitis; patients with positive results were excluded from analysis. Cirrhosis was defined on basis of clinical, biochemical, and radiological investigations and examinations...
September 17, 2017: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/28919631/right-atrial-myxoma-an-uncommon-presentation
#3
S K Shah, M Acharya, S I Alam, M A Hossain, M Aftabuddin
There are two types of tumors found in the cardiac chamber. These are divided into primary intra-cardiac tumors and secondary intra-cardiac tumors. Primary intra cardiac tumors are rare and among them 29% are myxomas. Majority of them are found in the left atrium. Here, we report a case of a myxoma in the right atrium with hepatomegaly and Hepatitis B virus infection. The coexistence of all these conditions is very rare. A 52 years old patient presented with history of shortness of breath on exertion along with fever and generalized weakness for 6 months which aggravated lately for last 2 months...
July 2017: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/28915429/neuroendocrine-tumor-of-the-extrahepatic-bile-duct-a-case-report
#4
Tsuyoshi Abe, Azuma Nirei, Nobuyasu Suzuki, Yukitoshi Todate, Ayaka Azami, Mitsuru Waragai, Atai Sato, Yoshinao Takano, Noriyuki Nishino, Hideo Sakuma, Yasushi Teranishi
INTRODUCTION: Neuroendocrine tumors (NETs) of the extrahepatic bile ducts are extremely rare neoplasms arising from endocrine cells and have variable malignant potential. They most commonly occur in young females and usually present with painless jaundice. PRESENTATION OF CASE: Here we present the case of an asymptomatic 57-year-old woman with NET of the common bile duct that was incidentally discovered on abdominal ultrasound during a medical examination. She was admitted to our hospital with a diagnosis of hepatic hilar tumor...
September 7, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28914407/association-of-fetuin-b-with-markers-of-liver-fibrosis-in-nonalcoholic-fatty-liver-disease
#5
Thomas Ebert, Nicolas Linder, Alexander Schaudinn, Harald Busse, Joachim Berger, Ralf Lichtinghagen, Volker Keim, Johannes Wiegand, Thomas Karlas
OBJECTIVE: The liver-derived plasma protein fetuin B is associated with nonalcoholic fatty liver disease (NAFLD) and impaired glucose homeostasis in mice. However, its association with non-invasive ultrasound- and magnetic resonance (MR)-based markers of liver fibrosis and steatosis, the enhanced liver fibrosis (ELF) score, liver biopsy, as well as rs738409 in PNPLA3, has not been elucidated in NAFLD, so far. DESIGN AND METHODS: The association of circulating fetuin B and transient elastography (TE), controlled attenuation parameter (CAP), (1)H-MR-spectroscopy, the ELF score, liver biopsy, as well as risk alleles in rs738409 in PNPLA3, was studied in 101 NAFLD patients as compared to 15 healthy controls...
September 15, 2017: Endocrine
https://www.readbyqxmd.com/read/28901853/synthesis-of-new-bis-spiropyrazoles-as-antitumor-agents-under-ultrasound-irradiation
#6
Naglaa A Abdel Hafez, Huwaida M E Hassaneen, Thoraya A Farghaly, Sayed M Riyadh, Heba S A Elzahabi
Hydrazonoyl halides used as precursors for synthesis of a new series of bis-spiropyrazolesvia reaction with 3,5-diarylidene-piperidone derivatives under ultrasound irradiation. The products were secluded in good yield after short reaction periods.The anti-cancer activity of bis-spiropyrazoles against HepG2 (hepatic cancer), A549 (lung cancer) and CaCo2 (colon cancer) cell lines were screened. Three tested compounds 4b, 4c and 4f showed promising activity.
September 12, 2017: Mini Reviews in Medicinal Chemistry
https://www.readbyqxmd.com/read/28900817/spleen-dimensions-are-inversely-associated-with-lysosomal-acid-lipase-activity-in-patients-with-non-alcoholic-fatty-liver-disease
#7
Licia Polimeni, Daniele Pastori, Francesco Baratta, Giulia Tozzi, Marta Novo, Roberto Vicinanza, Giovanni Troisi, Gaetano Pannitteri, Fabrizio Ceci, Laura Scardella, Francesco Violi, Francesco Angelico, Maria Del Ben
Fatty liver and splenomegaly are typical features of genetic lysosomal acid lipase (LAL) deficiency. No data in adult patients with non-genetic reduction of LAL activity are available. We investigate the association between spleen dimensions and LAL activity in non-alcoholic fatty liver disease (NAFLD) patients, in whom a reduced LAL activity has been reported. We include 425 consecutive patients who underwent abdominal ultrasound to evaluate hepatic steatosis and spleen dimensions. LAL activity was measured with dried blood spot method (Lalistat2)...
September 12, 2017: Internal and Emergency Medicine
https://www.readbyqxmd.com/read/28888355/the-correlation-of-controlled-attenuation-parameter-results-with-ultrasound-identified-steatosis-in-real-world-clinical-practice
#8
Yi-Hao Yen, Jung-Fu Chen, Cheng-Kun Wu, Ming-Tsung Lin, Kuo-Chin Chang, Po-Lin Tseng, Ming-Chao Tsai, Jung-Ting Lin, Tsung-Hui Hu
BACKGROUND/PURPOSE: Controlled attenuation parameter (CAP) is a method for measuring steatosis based on FibroScan. Despite observer dependency, ultrasound (US) robustly diagnoses moderate and severe steatosis. Here, we aimed to evaluate the correlation of CAP with US-identified steatosis in real-world clinical practice. METHODS: CAP and US were performed for 1554 chronic liver disease (CLD) patients. CAP was performed by two technicians, and US was performed by 30 hepatologists...
September 6, 2017: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/28886025/robust-phase-retrieval-based-x-ray-tomography-for-morphological-assessment-of-early-hepatic-echinococcosis-infection-in-rats
#9
Huiqiang Liu, Chuanshan Zhang, Xiaoxi Fan, Yingni Duan, Tiqiao Xiao, Guohao Du, Yanan Fu, Haigang Liu, Hao Wen
Propagation-based phase-contrast computed micro-tomography (PPCT) dominates the non-destructive, three-dimensional inner-structure measurement in synchrotron-based biomedical research due to its simple experimental setup. To quantitatively visualize tiny density variations in soft tissues and organs closely related to early pathological morphology, an experimental study of synchrotron-based X-ray PPCT combined with generalized phase and attenuation duality (PAD) phase retrieval was implemented with the hepatic echinococcosis (HE) infection rat model at different stages...
2017: PloS One
https://www.readbyqxmd.com/read/28883542/longitudinal-micro-ultrasound-assessment-of-the-ob-ob-mouse-model-evaluation-of-cardiovascular-renal-and-hepatic-parameters
#10
N Di Lascio, C Kusmic, F Stea, F Lenzarini, C Barsanti, A Leloup, F Faita
BACKGROUND/OBJECTIVES: Obesity is reaching epidemic proportions and is associated with increased risk factors for cardiovascular disease (CVD). Leptin-deficient mice (ob/ob) are widely employed to investigate obesity. Aim of this study was to provide a micro-ultrasound (μUS) longitudinal evaluation of the ob/ob mouse model in terms of cardiovascular effects, consequences for renal microcirculation and liver fat accumulation. SUBJECTS/METHODS: Sixteen wild-type (wt) and eleven ob/ob male mice were studied at 8 (T0) and 25 (T1) weeks of age with a μUS system (Vevo2100) and B-mode and Doppler images were acquired...
September 8, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28878671/a-pilot-study-evaluating-the-safety-of-intravenously-administered-human-amnion-epithelial-cells-for-the-treatment-of-hepatic-fibrosis
#11
Rebecca Lim, Alexander Hodge, Gregory Moore, Euan M Wallace, William Sievert
Liver cirrhosis is the 6th leading cause of death in adults aged 15-59 years in high-income countries. For many who progress to cirrhosis, the only prospect for survival is liver transplantation. While there is some indication that mesenchymal stem cells may be useful in reversing established liver fibrosis, there are limitations to their widespread use - namely their rarity, the need for extensive serial passaging and the associated potential for genomic instability and cellular senescence. To this end, we propose the use of allogeneic amnion epithelial cells...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28868358/glycogenic-hepatopathy-a-complication-of-uncontrolled-diabetes
#12
Medha Satyarengga, Yelena Zubatov, Sylvaine Frances, Gopal Narayanswami, Rodolfo J Galindo
OBJECTIVE: To describe a case of hepatomegaly and elevated transaminases in a patient with glycogenic hepatopathy (GH) as a complication of uncontrolled diabetes. METHODS: Clinical, laboratory, and pathological information are described. RESULTS: An 18-year-old male with uncontrolled type 1 diabetes and recurrent diabetic ketoacidosis (DKA) presented with abdominal distention and severe hyperglycemia. Physical examination revealed massive hepatomegaly...
2017: AACE Clinical Case Reports
https://www.readbyqxmd.com/read/28864693/ablation-with-irreversible-electroporation-in-patients-with-advanced-perihilar-cholangiocarcinoma-alpaca-a-multicentre-phase-i-ii-feasibility-study-protocol
#13
Robert J S Coelen, Jantien A Vogel, Laurien G P H Vroomen, Eva Roos, Olivier R C Busch, Otto M van Delden, Foke van Delft, Michal Heger, Jeanin E van Hooft, Geert Kazemier, Heinz-Josef Klümpen, Krijn P van Lienden, Erik A J Rauws, Hester J Scheffer, Henk M Verheul, Jan de Vries, Johanna W Wilmink, Barbara M Zonderhuis, Marc G Besselink, Thomas M van Gulik, Martijn R Meijerink
INTRODUCTION: The majority of patients with perihilar cholangiocarcinoma (PHC) has locally advanced disease or distant lymph node metastases on presentation or exploratory laparotomy, which makes them not eligible for resection. As the prognosis of patients with locally advanced PHC or lymph node metastases in the palliative setting is significantly better compared with patients with organ metastases, ablative therapies may be beneficial. Unfortunately, current ablative options are limited...
September 1, 2017: BMJ Open
https://www.readbyqxmd.com/read/28863378/right-hepatectomy-after-spontaneous-hepatic-rupture-in-a-patient-with-preeclampsia-a-case-report
#14
Carlos A Millan, Juan C Forero
INTRODUCTION: Spontaneous hepatic rupture associated with preecalmpsia or HELLP syndrome is a rare and life threatining event, only 200 cases have been reported in the literature. PRESENTATION OF CASE: We present a case of a 31 year old female with 28 weeks of gestation that presented with acute abdominal pain, elevated blood pressure and altered liver enzymes an abdominal ultrasound that showed a subcapsular hematoma occupying the whole right lobe and free abdominal fluid, she required emergent laparotomy, C-section, hepatic packing, followed by angioembolization and finally right hepatectomy...
August 18, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28862247/ectopic-adrenocorticotropic-hormone-syndrome-in-a-case-of-duodenal-neuroendocrine-tumor-presenting-with-liver-metastasis
#15
J Khare, S Daga, S Nalla, P Deb
Ectopic adrenocorticotropic hormone (ACTH) syndrome is an uncommon disorder and comprises about 15% of all patients with Cushing's syndrome (CS). Duodenal carcinoids are rare, indolent tumors usually associated with a benign progression. We hereby report a rare case of CS resulting from ectopic ACTH secretion from a duodenal neuroendocrine tumor (NET) presenting with liver metastasis. A 37-year-old female presented with abdominal discomfort and dyspepsia of 1-month duration. Ultrasound abdomen suggested a well-defined hypoechoic lesion in the left lobe of the liver, suggestive of neoplasia...
August 31, 2017: Journal of Postgraduate Medicine
https://www.readbyqxmd.com/read/28861720/accurate-identification-of-fatty-liver-disease-in-data-warehouse-utilizing-natural-language-processing
#16
Joseph S Redman, Yamini Natarajan, Jason K Hou, Jingqi Wang, Muzammil Hanif, Hua Feng, Jennifer R Kramer, Roxanne Desiderio, Hua Xu, Hashem B El-Serag, Fasiha Kanwal
INTRODUCTION: Natural language processing is a powerful technique of machine learning capable of maximizing data extraction from complex electronic medical records. METHODS: We utilized this technique to develop algorithms capable of "reading" full-text radiology reports to accurately identify the presence of fatty liver disease. Abdominal ultrasound, computerized tomography, and magnetic resonance imaging reports were retrieved from the Veterans Affairs Corporate Data Warehouse from a random national sample of 652 patients...
August 31, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28861635/diffusion-weighted-imaging-of-the-pericholecystic-hepatic-parenchyma-for-distinguishing-acute-and-chronic-cholecystitis
#17
Avneesh Gupta, Christina A LeBedis, Jennifer Uyeda, Mohammed M Qureshi, Stephan W Anderson, Jorge A Soto
PURPOSE: The purpose of this study is to measure the performance of restricted diffusion of the pericholecystic hepatic parenchyma for distinguishing between acute and chronic cholecystitis. METHODS: The institutional review board approved this HIPAA-compliant retrospective study. Two hundred sixty-six patients presenting with acute right upper quadrant pain between 10/3/2010 and 11/28/2012 undergoing MR within 48 h of equivocal utility of ultrasound (US) were included...
August 31, 2017: Emergency Radiology
https://www.readbyqxmd.com/read/28856286/hepatitis-d-b-and-c-virus-hdv-hbv-hcv-coinfection-as-a-diagnostic-problem-and-therapeutic-challenge
#18
Beata Lorenc, Katarzyna Sikorska, Piotr Stalke, Krzysztof Bielawski, Dominik Ziętkowski
Coinfection with hepatitis D virus (HDV) in chronic hepatitis B is associated with more rapid progression to liver cirrhosis. We present two cases of infection with hepatitis D, B and C viruses. Both male patients were primarily diagnosed as infected with hepatitis B virus (HBV) and hepatitis C virus (HCV), HBsAg-positive and anti-HCV-positive. The first patient was treated with interferon, lamivudine and pegylated interferon. A full virological and biochemical response was achieved. The second patient was treated with interferon and ribavirin, lamivudine and twice with pegylated interferon...
March 2017: Clin Exp Hepatol
https://www.readbyqxmd.com/read/28856019/detailed-efsum-recommendations-on-the-scope-of-ultrasound-assessment-in-patients-with-portal-hypertension-considering-the-diagnostic-reference-level
#19
REVIEW
Andrzej Smereczyński, Katarzyna Kołaczyk
An important paper describing the Standards of the Polish Ultrasound Society regarding the assessment of portal and hepatic vasculature was published in the Journal of Ultrasonography. Due to the multiplicity of morphological and hemodynamic data required, the time needed to obtain these data and the legal responsibility of doctors for the results, there seems to be a need to determine a clear range of the assessed parameters depending on the reference level of a given healthcare facility. Therefore, the aim of the paper was to present the EFSUMB recommendations on the range of the evaluated ultrasonographic parameters in portal hypertension depending on the reference level...
June 2017: Journal of Ultrasonography
https://www.readbyqxmd.com/read/28855998/surgery-is-the-preferred-treatment-for-bile-duct-hamartomas
#20
Xiao-Yu Yang, Hai-Bo Zhang, Bin Wu, Ai-Jun Li, Xiao-Hui Fu
Bile duct hamartoma (BDH) is a rare liver disease with a rising incidence in recent years. A retrospective study on BDH patients between June 2007 and December 2015 was conducted. All the medical records, including clinical, imaging and pathological characteristics, were retrieved. Follow-up data were obtained by telephone communication. The majority of the patients had no symptoms and the laboratory tests were normal. The appearance on ultrasound examination was variable. The lesion exhibited low density on plain computed tomography and no enhancement in 4 cases, and inhomogeneous enhancement in 1 case...
October 2017: Molecular and Clinical Oncology
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