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Pancreatic ultrasound

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https://www.readbyqxmd.com/read/29665583/clinical-effectiveness-and-potential-survival-benefit-of-us-guided-high-intensity-focused-ultrasound-therapy-in-patients-with-advanced-stage-pancreatic-cancer
#1
Milka Marinova, Hannah C Huxold, Jana Henseler, Martin Mücke, Rupert Conrad, Roman Rolke, Hojjat Ahmadzadehfar, Maximilian Rauch, Rolf Fimmers, Guido Luechters, Henning Cuhls, Lukas Radbruch, Hans H Schild, Holger Strunk
PURPOSE:  Pancreatic cancer (PaC) is a life-limiting tumor with a wide range of incapacitating symptoms such as cancer pain in more than 80 % of patients. This prospective interventional study addresses the clinical effectiveness of ultrasound-guided high-intensity focused ultrasound (HIFU) treatment for patients with advanced-stage PaC, including pain perception, tumor size and survival benefit. MATERIALS AND METHODS:  50 patients with late-stage PaC underwent HIFU...
April 17, 2018: Ultraschall in der Medizin
https://www.readbyqxmd.com/read/29665210/endoscopic-ultrasound-diagnosis-of-merkel-cell-carcinoma-metastasizing-to-pancreas
#2
Juliana Pinho, Diana Montezuma, Paula Monteiro, Mário Dinis-Ribeiro, Pedro Bastos
Merkel cell carcinoma (MCC) is a rare and aggressive primary neuroendocrine tumor of the skin, with a high propensity for local, regional and distant spread1 . However, distant metastasis of MCC to the pancreas are rarely seen. EUS-FNA is an effective tool in the evaluation and differential diagnosis of pancreatic mass lesions3 . Differentiating metastatic pancreatic tumors, especially Merkel cell carcinoma, from primary pancreatic tumor will influence clinical management and therapeutic strategies2 . This article is protected by copyright...
April 17, 2018: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/29657730/lemierre-s-syndrome-presented-with-acute-pancreatitis
#3
Laura Garcia, Kaori Ito
Case: Lemierre's syndrome is a rare clinical condition that is characterized by infected internal jugular vein thrombosis with metastatic septicemia. The most common causative agent is Fusobacterium necrophorum . A previously healthy 37-year-old woman presented to our emergency department with nausea, vomiting, and diarrhea. She was admitted to the general practice unit with a diagnosis of acute pancreatitis then was subsequently transferred to the intensive care unit due to shock. Physical examination revealed tenderness on right side of the neck...
April 2018: Acute Medicine & Surgery
https://www.readbyqxmd.com/read/29653222/gemcitabine-loaded-microbubbles-for-targeted-chemo-sonodynamic-therapy-of-pancreatic-cancer
#4
Heather Nesbitt, Yingjie Sheng, Sukanta Kamila, Keiran Logan, Keith Thomas, Bridgeen Callan, Mark A Taylor, Mark Love, Declan O'Rourke, Paul Kelly, Estelle Beguin, Eleanor Stride, Anthony P McHale, John F Callan
Pancreatic cancer remains one of the most lethal forms of cancer with a 10-year survival of <1%. With little improvement in survival rates observed in the past 40 years, there is a significant need for new treatments or more effective strategies to deliver existing treatments. The antimetabolite gemcitabine (Gem) is the most widely used form of chemotherapy for pancreatic cancer treatment, but is known to produce significant side effects when administered systemically. We have previously demonstrated the benefit of combined chemo-sonodynamic therapy (SDT), delivered using oxygen carrying microbubbles (O2 MB), as a targeted treatment for pancreatic cancer in a murine model of the disease...
April 11, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29650926/-a-resected-case-of-adenosquamous-carcinoma-of-pancreas-that-relapsed-in-remnant-pancreas
#5
Kotaro Miura, Akishige Kanazawa, Sadatoshi Shimizu, Akihiro Murata, Shintaro Kodai, Takafumi Nishii, Katsunobu Sakurai, Akiko Tachimori, Yutaka Tamamori, Naoshi Kubo, Toru Inoue, Yukio Nishiguchi
A 70's man underwent subtotal stomach preserving pancreatoduodenectomy(SSPPD)for pancreatic head cancer. The pathological diagnosis was adenosquamous carcinoma(ASC)of the pancreas. Two months after surgery, a recurrent tumor in the remnant pancreas was confirmed with a CT scan and suspected to be ASC by endoscopic ultrasound-guided fine needle aspiration(EUS-FNA). As the recurrent lesion was limited in the pancreas, total remnant pancreatectomy(TP)was performed 4 months after SSPPD. The final pathological diagnosis was ASC...
March 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29629316/management-of-functional-neuroendocrine-tumors-of-the-pancreas
#6
REVIEW
Kjell Öberg
Pancreatic neuroendocrine tumors (pNETs) constitute a heterogenous group of malignancies with varying clinical presentation, tumor biology and prognosis. The incidence of pNETs has steadily increased during the last decades with an estimated incidence 2012 of 4.8/100,000. Recent whole genome sequencing of pNETs has demonstrated mutations in the DNA repair genes MUTYH and point mutations and gene fusions in four main pathways from chromatin remodeling, DNA damage repair, activation of mechanistic target of rapamycin (mTOR) signaling and the telomere maintenance...
February 2018: Gland Surgery
https://www.readbyqxmd.com/read/29629315/surgical-resection-of-neuroendocrine-tumors-of-the-pancreas-pnets-by-minimally-invasive-surgery-the-laparoscopic-approach
#7
REVIEW
Tomoki Shirota, Yuichi Nagakawa, Yatsuka Sahara, Chie Takishita, Yosuke Hijikata, Yuichi Hosokawa, Tetsushi Nakajima, Hiroaki Osakabe, Kenji Katsumata, Akihiko Tsuchida
Neuroendocrine tumors of the pancreas (pNETs) are a rare group of neoplasms that originate from the endocrine portion of the pancreas. Tumors that either secrete or do not secrete compounds, resulting in symptoms, can be classified as functioning and non-functioning pNETs, respectively. The prevalence of such tumors has recently increased due to the use of more sensitive imaging techniques, such as multidetector computed tomography, magnetic resonance imaging and endoscopic ultrasound. The biological behavior of pNETs varies widely from indolent, well-differentiated tumors to those that are far more aggressive...
February 2018: Gland Surgery
https://www.readbyqxmd.com/read/29623911/a-multicenter-evaluation-of-a-new-eus-core-biopsy-needle-experience-in-200-patients
#8
Douglas G Adler, V Raman Muthusamy, Dean S Ehrlich, Gulshan Parasher, Nirav C Thosani, Ann Chen, Jonathan M Buscaglia, Anoop Appannagari, Eduardo Quintero, Harry Aslanian, Linda Jo Taylor, Ali Siddiqui
Background and Objectives: We present a multicenter study of a new endoscopic ultrasound-guided fine-needle biopsy (EUS-FNB) needle (Acquire, Boston Scientific, Natick, MA). The aim of the study was to analyze the needle's clinical performance when sampling solid lesions and to assess the safety of this device. Methods: We performed a multicenter retrospective study of patients undergoing EUS-FNB during July 1-November 15, 2016. Results: Two hundred patients (121 males and 79 females) underwent EUS-FNB of solid lesions with the Acquire needle...
April 4, 2018: Endoscopic Ultrasound
https://www.readbyqxmd.com/read/29604531/the-successful-salvage-of-a-thrombosed-pancreatic-graft-at-the-early-postoperative-period-of-a-simultaneous-pancreas-and-kidney-transplantation
#9
Rauf Shahbazov, Feredun Azari, Park Auh Whan, Liu Wei, Avinash Agarwal, Kenneth L Brayman
INTRODUCTION: Simultaneous kidney and pancreas transplant is the preferred treatment option for end-stage renal disease due to type 1 diabetic nephropathy. Vascular complications are detrimental to graft survival and can lead to graft loss in the early postoperative phase of transplantation. Generally, duplex Doppler ultrasound is used for vascular patency monitoring and pancreatectomy followed by re-transplantation is required in the majority of cases. Recently, pancreatic graft salvage with non-operative management, including medical anticoagulation and endovascular thrombectomy, in the early postoperative period has been described with success...
March 16, 2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29603000/prospective-histological-evaluation-of-a-20g-core-trap-with-a-forward-cutting-bevel-needle-for-eus-fna-of-pancreatic-lesions
#10
Nobu Nishioka, Takeshi Ogura, Yoshitaka Kurisu, Miyuki Imanishi, Saori Onda, Wataru Takagi, Tatsushi Sano, Atsushi Okuda, Akira Miyano, Mio Amano, Kazuhide Higuchi
BACKGROUND: Endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) has been established as a method to obtain tissues of various organs. To obtain sufficient tissue has clinical impact to facilitate the diagnosis by clinical pathologists, the assessment and subtyping of various neoplasms, and for further immunohistochemical investigations of tumor type. Recently, a novel 20G core trap with a forward-cutting beveled FNA needle (ProC-F) has become available. The aim of this prospective study was to evaluate the feasibility and diagnostic yield of EUS-FNA for pancreatic lesions using this needle...
March 30, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29601903/endoscopic-drainage-of-pancreatic-fluid-collections
#11
REVIEW
B Joseph Elmunzer
Endoscopy has emerged as a mainstay in the management of pancreatic fluid collections (PFCs), representing an important advance in clinical medicine that has significantly improved the risk-benefit ratio of treating this complex patient population. While endoscopic pseudocyst drainage has generally supplanted surgical and percutaneous approaches, the optimal strategy for walled-off necrosis remains variable and multi-disciplinary despite an emerging trend from randomized trials favoring endoscopy. Although several issues pertaining to endoscopic drainage appear to have been settled - such as the use of endoscopic ultrasound - other pressing questions - including the optimal prosthesis and debridement strategy - remain unanswered, and rigorous investigation is needed...
March 27, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29600794/fluid-collection-after-partial-pancreatectomy-eus-drainage-and-long-term-follow-up
#12
Fabrice Caillol, Sebastien Godat, Olivier Turrini, Christophe Zemmour, Erwan Bories, Christian Pesenti, Jean Phillippe Ratone, Jacques Ewald, Jean Robert Delpero, Marc Giovannini
Background and Objectives: Postoperative fluid collection due to pancreatic leak is the most frequent complication after pancreatic surgery. Endoscopic ultrasound (EUS)-guided drainage of post-pancreatic surgery fluid collection is the gold standard procedure; however, data on outcomes of this procedure are limited. The primary endpoint of our study was relapse over longterm followup, and the secondary endpoint was the efficiency and safety of EUS-guided drainage of post-pancreatic surgery fluid collection...
March 29, 2018: Endoscopic Ultrasound
https://www.readbyqxmd.com/read/29600477/in-vivo-study-of-enhanced-chemotherapy-combined-with-ultrasound-image-guided-focused-ultrasound-usgfus-treatment-for-pancreatic-cancer-in-a-xenograft-mouse-model
#13
Eun-Joo Park, Yun Deok Ahn, Jae Young Lee
OBJECTIVES: This study was designed to investigate whether focused ultrasound (FUS) treatment with a higher mechanical index (MI) can enhance the effects of combined chemotherapy more than with a lower MI, and to evaluate the feasibility of the chemotherapy combined with FUS at a higher MI as an alternative treatment protocol. METHODS: Mice in the first study were divided into six groups: control, chemotherapy only (GEM), two groups treated with FUS only at two different MIs, and two groups treated with chemotherapy and FUS (GEM + FUS)...
March 29, 2018: European Radiology
https://www.readbyqxmd.com/read/29600432/catheter-probe-extraductal-ultrasound-edus-exploration-of-the-common-bile-duct-is-safe-in-elderly-patients-with-suspicion-of-choledocholithiasis-after-distal-gastrectomy
#14
Thomas Togliani, Stefano Pilati, Andrea Lisotti, Giancarlo Caletti, Pietro Fusaroli
PURPOSE: Post-surgical upper gastrointestinal anatomy may hamper a complete bilio-pancreatic evaluation with a standard echoendoscope. The aim of this study was to assess the role of catheter probe extraductal ultrasound (EDUS) for the evaluation of the common bile duct (CBD) in patients who are status post-gastric surgery and who are suspected of having choledocholithiasis. METHODS: We retrospectively analyzed patients with a prior history of gastric surgery, who underwent EDUS for a suspicion of CBD obstruction...
March 29, 2018: Abdominal Radiology
https://www.readbyqxmd.com/read/29595661/fine-needle-biopsy-is-superior-to-fine-needle-aspiration-in-endoscopic-ultrasound-guided-sampling-of-pancreatic-masses-a-meta-analysis-of-randomized-controlled-trials
#15
Hong Li, Wei Li, Qiu-Yuan Zhou, Bin Fan
BACKGROUND: The comparison between endoscopic ultrasound (EUS) guided fine needle aspiration (FNA) and EUS guided fine needle biopsy (FNB) in sampling pancreatic masses is still controversial. METHODS: A systematic search was conducted in PubMed and Web of Science to identify all relevant randomized controlled trials (RCTs). Odds ratios (OR) and 95% confidence intervals (95% CI) were calculated for dichotomous outcomes of interest (specimen adequacy, diagnostic accuracy, complications, and technical success), while mean difference (MD) and 95% CI were pooled for continuous variables (number of needle passes required for diagnosis)...
March 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29590668/safety-of-lumen-apposing-stent-with-or-without-coaxial-plastic-stent-for-endoscopic-ultrasound-guided-drainage-of-pancreatic-fluid-collections-a-retrospective-study
#16
Manuel Puga, Claudia F Consiglieri, Juli Busquets, Natàlia Pallarès, Lluis Secanella, Nuria Peláez, Joan Fabregat, José Castellote, Joan B Gornals
BACKGROUND:  The aim of this study was to evaluate whether the placement of a coaxial double-pigtail plastic stent (DPS) within a lumen-apposing metal stent (LAMS) may improve the safety of endoscopic ultrasound (EUS)-guided drainage of pancreatic fluid collections (PFCs). METHODS:  This was a retrospective cohort study including patients with PFCs and an indication for transmural drainage. Two strategies (LAMS alone or LAMS plus DPS) were used at the endoscopist's discretion...
March 28, 2018: Endoscopy
https://www.readbyqxmd.com/read/29581692/rupture-of-cystic-artery-pseudoaneurysm-a-rare-complication-of-acute-cholecystitis
#17
P R V Praveen Kumar Sunkara, Parth Ketankumar Shah, Kamalesh Rakshit, Shuvro Roy Choudhary, N P Bohidar, Sanjay Kumar Dubey
Pseudoaneurysm (PA) of the cystic artery is rare. Most of the reported cases are iatrogenic and develop secondary to liver biopsy, laparoscopic cholecystectomy, ERCP, and liver transplant. Other reported causes include trauma, malignancy, arteriovenous malformations, and inflammation in the hepatobiliary and pancreatic system. Cystic artery psuedoaneurysm is usually asymptomatic but may also present as vague abdominal pain, intra-abdominal mass, and hemobilia. In the event of rupture, it may present as a catastrophic intra-peritoneal bleeding with hemorrhagic shock...
February 2018: Indian Journal of Surgery
https://www.readbyqxmd.com/read/29579746/good-agreement-between-transabdominal-and-endoscopic-ultrasound-of-the-pancreas-in-chronic-pancreatitis
#18
Trond Engjom, Khahn Do-Chong Pham, Friedemann Erchinger, Ingfrid Salvesen Haldorsen, Odd Helge Gilja, Georg Dimcevski, Roald Flesland Havre
PURPOSE:  We aimed to evaluate the agreement of single criteria and dedicated scores from transabdominal ultrasound of the pancreas (US) compared to standards by endoscopic ultrasound (EUS) and computed tomography (CT). MATERIALS AND METHODS:  In this observational cohort study performed in a tertiary care center, US and EUS were performed in 110 patients referred for suspected CP. Based on the Mayo score, 52 patients were diagnosed with CP. The sonographic findings obtained by both methods were registered...
March 26, 2018: Ultraschall in der Medizin
https://www.readbyqxmd.com/read/29576248/ultrasound-guided-percutaneous-core-needle-biopsy-for-the-diagnosis-of-pancreatic-disease
#19
REVIEW
Ying Huang, Jingwen Shi, Yun-Yun Chen, Kao Li
Few studies have evaluated the performance of percutaneous core needle biopsies of the pancreas. This article is an overview of the advantages, disadvantages, predictive power and complications associated with percutaneous ultrasound-guided core needle biopsies of pancreatic lesions. A comprehensive literature search of Medline (using PubMed as the search engine) and EMBASE was done to identify suitable studies up to March 2017. A study of quantitative pre-operative pancreatic biopsy data was reported. Lesion location, mean or median number of passes, inadequate tissue or technical failures and complications were assessed for all cases by reviewing clinical notes and post-procedural imaging...
March 22, 2018: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/29576017/diagnostic-double-strike-in-the-emergency-room-two-cases-of-complete-pancreatic-ruptures-due-to-bicycle-handlebar-injuries-on-two-consecutive-days
#20
A M Luu, K Meurer, T Herzog, W Uhl, C Braumann
BACKGROUND: Pancreatic injuries are rare in cases of blunt abdominal trauma and therefore easily misdiagnosed at time of hospital admission. They are associated with a significantly elevated morbidity and lethality. Bicycle handlebar injuries are the most common cause of pancreatic trauma in children and adolescents. CASE PRESENTATION: We report two cases of a 23-year-old Caucasian woman and a 15-year-old Caucasian boy who presented to our clinic with a similar history of a bicycle accident on 2 consecutive days...
March 26, 2018: Journal of Medical Case Reports
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