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Minling Gao, Yu Liu, Youming Dong, Zhengguo Song
Di(2-ethylhexyl) phthalate (DEHP) is a commonly used, artificially-synthesized, industrial chemical that can be released into the soil. However, to date, there is no comprehensive study on the effects of DEHP on photosynthesis, induction of reactive oxygen species, and response of the antioxidant defense system in wheat plants growing in DEHP contaminated soil. This study was conducted to address this gap in knowledge. Our results showed that after application of 10, 20, and 40 mg/kg DEHP, photosynthetic parameters, fluorescence parameters, and chlorophyll content of wheat leaves at seedling, jointing, and booting stages decreased, while the intercellular carbon dioxide concentration increased...
June 14, 2018: Chemosphere
Roger J Hart, Hanne Frederiksen, Dorota A Doherty, Jeffrey A Keelan, Niels E Skakkebaek, Noviani S Minaee, Robert McLachlan, John P Newnham, Jan E Dickinson, Craig E Pennell, Robert J Norman, Katharina M Main
Phthalates are ubiquitous environmental endocrine-disrupting chemicals suspected to interfere with developmental androgen action leading to adverse effects on male reproductive function. Prenatal exposure studies in rodents show cryptorchidism, hypospadias and reduced testicular volume (TV), testosterone and anogenital distance in males. It is postulated that there is a developmental window in utero when phthalate exposure has the most potent adverse effects. Some human studies show associations between prenatal phthalate exposure and reduced calculated "free" serum testosterone in infant boys and shorter anogenital distance...
2018: Frontiers in Endocrinology
Christina Hartmann, Maria Uhl, Stefan Weiss, Sigrid Scharf, Jürgen König
Reference values (RV95 ) are statistically derived values comprising the rounded 95th percentiles within the 95% confidence interval and indicate the upper margin of background exposure to chemical substances in a population at a given time period. Based on representative national human biomonitoring data on several urinary phthalate metabolites in children, adolescents and adults from 2010 to 2011, RV95 were derived for the Austrian population based on a IUPAC guideline and the recommendation of the German Human Biomonitoring Commission...
June 13, 2018: International Journal of Hygiene and Environmental Health
Heng Wang, Liangpo Liu, Heqing Shen
OBJECTIVE: Monitoring infants' exposure to 10 phthalates by measuring their urinary metabolites using a modified high performance liquid chromatography tandemelectrospray ionization mass spectrometry( HPLC-ESI-MS/MS) method. METHODS: A total of 50 infants at 0-6 month-old were recruited and their urine samples were collected by commercial available gel diapers. After the urine expression, phthalates were hydrolyzed by β-glucuronidase, cleaned up by HLB cartridge, then these metabolites were measured by HPLC-ESI-MS/MS equipped with a Hypersil Gold Phenyl column...
July 2017: Wei Sheng Yan Jiu, Journal of Hygiene Research
Xiyan Mu, Ying Huang, Jia Li, Ke Yang, Wenbo Yang, Gongming Shen, Xuxing Li, Yunlei Lei, Sen Pang, Chengju Wang, Xuefeng Li, Yingren Li
To investigate the biological pathways involved in phthalate-induced developmental effects, zebrafish embryos were exposed to different concentrations of di-(2-ethylhexyl) (DEHP) and di-butyl phthalate (DBP) for 96 h. Embryonic exposure to DEHP and DBP induced body length decrease, yolk sac abnormities, and immune responses (up-regulation of immune proteins and genes). The lipidomic results showed that at a concentration of 50 μg/L, DEHP and DBP significantly reduced the levels of fatty acids, triglycerides, diacylglycerol, and cholesterol...
June 11, 2018: Environmental Pollution
Jian Zhao, Shi Ren, Chunyu Liu, Li Huo, Zheng Liu, Lingling Zhai
Objective: This study evaluated the effects of di-(2-ethylhexyl) phthalate (DEHP) and obesity on male reproductive organ function in male mice and the potential mechanism of male secondary hypogonadism (SH) in such mice. Methods: 140 mice were assigned to six groups for 12 weeks: normal, DEHP, DIO, DIO + DEHP low, DIO + DEHP middle, and DIO + DEHP high. The effects of DEHP and obesity upon the reproductive organs were determined by measuring sperm count and motility, relative testis and epididymis weight, hormone level, and pathological changes...
2018: Oxidative Medicine and Cellular Longevity
Nosrat Bahrami, Saeed Mehrzadi, Mehdi Goudarzi, Esrafil Mansouri, Iman Fatemi
Di (2-ethylhexyl) phthalate (DEHP) is one of the environmental pollutants that causes testicular damage. Lycopene (LYCO), the main active carotenoid in red fruits and vegetables, has well-known antiinflammatory and antioxidant activities. The present study aimed to investigate the effects of LYCO on DEHP-induced testicular injury in male mice. DEHP (2 g/kg, p.o.) was given for two weeks to mice. LYCO was given at 4 mg/kg, p.o., for two weeks, starting the same day of DEHP insult. Serum testosterone, luteinizing hormone and follicle stimulating hormone and testicular total antioxidant status, malondialdehyde, nitric oxide, glutathione, superoxide dismutase, glutathione peroxidase, catalase, tumor necrosis factor-α, interleukin-1β were measured...
June 7, 2018: Life Sciences
Yue Wang, Shiyong Bao, Guoli Shen, Jun Wang, Hongqiang Jiang
As we all know, DEHP is seriously harmful to human health and consequently has been acquired critical attention. DEHP is able to migrate from PVC medical devices for the non-chemically bound to PVC, thus contact with user and patient. The DEHP migration is influenced by various parameters. In order to assess the security of PVC-tubes medical devices scientifically of DEHP migration, we develop an experimental model by analyzing the parameters comprehensively and systematically, taking into account the clinical practices...
May 30, 2018: Zhongguo Yi Liao Qi Xie za Zhi, Chinese Journal of Medical Instrumentation
Cheng-Di Dong, Chiu-Wen Chen, Chang-Mao Hung
Phthalate esters (PAEs) can interfere with the endocrine systems of humans and wildlife. The main objective of this study was to evaluate the suitability of a composite for remediating marine sediments contaminated with PAEs. The composite was synthesized with magnetite nanoparticles (Fe3 O4 ) and rice husk biochar (RHB) by using chemical co-precipitation. Fe3 O4 , RHB, and Fe3 O4 -RHB substantially activated sodium persulfate (Na2 S2 O8 , PS) oxidation to form SO4 -• and thus degrade PAEs in marine sediments in a slurry system...
June 4, 2018: Environmental Science and Pollution Research International
Wen-Kai Yang, Li-Fen Chiang, Shi-Wei Tan, Pei-Jen Chen
Di(2-ethylhexyl)phthalate (DEHP) is a commonly used plasticizer, with evidence of ubiquitous human exposure and widespread occurrence in the aquatic environment. It is an emerging environmental pollutant with regulatory priority; however, most studies have focused on the toxicity of DEHP related to endocrine disruption and reproduction in mammals. The ecotoxicological impact of phthalates (e.g., DEHP) on early life stages of fish under environmentally relevant concentrations of chronic exposure remains unclear...
June 1, 2018: Science of the Total Environment
M A Martínez, J Rovira, R Prasad Sharma, M Nadal, M Schuhmacher, V Kumar
Bisphenol A (BPA) and Di-(2-ethylhexyl) phthalate (DEHP) are two wide spread chemicals classified as endocrine disruptors (ED). The present study aims to estimate the non-dietary (dermal, non-dietary ingestion and inhalation) exposure to BPA and DEHP for a pregnant women cohort. In addition, to assess the prenatal exposure for the fetus, a physiologically based pharmacokinetic (PBPK) model was used. It was adapted for pregnancy in order to assess the internal dosimetry levels of EDs (BPA and DEHP) in the fetus...
May 30, 2018: Environmental Research
Ying Chen, Dong Lv, Xinghua Li, Tianle Zhu
Phthalates (phthalates esters, PAEs) are ubiquitous contaminants in various indoor and outdoor environment. Exposure to PAEs exerts adverse effects on human health. Seasonal variations of air phthalate concentrations and paired indoor and outdoor air phthalate level are rarely known. In this study, six priority phthalates in PM2.5 were investigated in three indoor sites (a students' dormitory, a residential apartment and an office) and one outdoor site in Beijing, China across four seasons. PM2.5 samples were collected at indoor and outdoor environment simultaneously...
May 28, 2018: Environmental Pollution
Reiko Kishi, Atsuko Araki, Chihiro Miyashita, Sachiko Itoh, Machiko Minatoya, Sumitaka Kobayashi, Keiko Yamazaki, Yu Ait Bamai, Ryu Miura, Naomi Tamura
Since "Our Stolen Future" by Theo Colborn was published in 1996, global interest on the impact of chemical substances, such as the endocrine-disrupting action of chemicals, has increased. In Japan, "The Hokkaido Study on Environment and Children's Health: Malformation, Development and Allergy" was launched in 2001. It was a model of Japan Environment and Children's Study of the Ministry of the Environment. In a large-scale, Hokkaido cohort, we obtained the consent of 20,926 mothers at the organogenesis stage with the cooperation of 37 obstetrics clinics in Hokkaido...
2018: Nihon Eiseigaku Zasshi. Japanese Journal of Hygiene
Seul Min Choi, Duck Soo Lim, Min Kook Kim, Sungpil Yoon, Sam Kacew, Hyung Sik Kim, Byung-Mu Lee
The endocrine disrupting actions of di(2-ethylhexyl) phthalate (DEHP) on testicular functions are postulated to involve excess free radical generation. Thus the aim of this study was to examine the ability of antioxidant vitamins C and E to prevent DEHP-induced testicular disruption in male Sprague-Dawley (SD) rats. SD male rats were administered DEHP alone or DEHP with vitamin C and/or vitamin E for 30 days. DEHP alone increased the levels of testosterone (T) and reduced estradiol (E2 ) concentrations. Supplementation with antioxidant vitamins diminished or restored serum T levels noted in DEHP-treated rats to control values...
May 29, 2018: Journal of Toxicology and Environmental Health. Part A
Donatella Caserta, Samantha Pegoraro, Maddalena Mallozzi, Luisa Di Benedetto, Elena Colicino, Luana Lionetto, Maurizio Simmaco
Endocrine disruptors (EDs) are known to affect maternal and child health. The objective of our study was to identify the association between some of the most important endocrine-disruptive substances (perfluorooctane sulfonate [PFOS], perfluorooctanoic acid [PFOA], di2-ethylhexyl-phthalate [DEHP] and mono2-ethylhexyl-phthalate [MEHP]) and both pregnancy variability and birth outcomes. We measured the concentration of the EDs in maternal and cord blood samples of 29 mother-newborn pairs from the Pertini Hospital in Rome between March and June 2016...
May 29, 2018: Gynecological Endocrinology
Jin Hee Kim
Uterine leiomyoma is the most common benign tumor type of the female reproductive tract. Despite its high prevalence, the exact pathogenesis of the benign tumor remains unknown. In the present study, the effects of di-(2-ethylhexyl) phthalate (DEHP) on the proliferation and apoptosis rates and expression of inflammatory proteins in human leiomyoma cells were evaluated. The effects of DEHP on cell viability were determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. The effects on apoptosis were evaluated by western blotting, TUNEL assay and Annexin V staining...
June 2018: Experimental and Therapeutic Medicine
Jingjing Pei, Yahong Sun, Yihui Yin
Semi-volatile organic compounds (SVOCs) are one of the main indoor pollutant categories. Six phthalates (dimethyl phthalate (DMP), diethyl phthalate (DEP), di(isobutyl) phthalate (DiBP), di(nbutyl) phthalate (DnBP), butyl benzyl phthalate (BBzP) and di(2-ethylhexyl) phthalate (DEHP)) in house dust samples were measured in forty residential apartments in Tianjin and Urumqi in four seasons throughout a year. The measured DEHP dust-phase concentration is in the range: 11.9-699.9 μg/g; and showed obvious differences in different seasons, and the maximum can be 2 times higher than minimum...
May 23, 2018: Science of the Total Environment
Yuan Wang, Tianyi Wang, Yanli Ban, Chenchen Shen, Qi Shen, Xiaojie Chai, Wen Zhao, Jie Wei
Di-(2-ethylhexyl) phthalate (DEHP) is a plasticizer used in the polyvinyl chloride industry worldwide. DEHP exists in the aquatic environments for decades. However, the toxicological effects of DEHP to aquatic organisms have not been adequately researched. We investigated acute toxicity, oxidative damage, antioxidant enzyme activities, and gene expression patterns of antioxidant enzymes in juvenile and adult Daphnia magna exposed to DEHP. We found that the median lethal concentrations (LC50 ) of DEHP for juveniles exposed for 24 and 48 h were 0...
May 24, 2018: Archives of Environmental Contamination and Toxicology
Isabel Forner-Piquer, Stefania Santangeli, Francesca Maradonna, Alessandro Rabbito, Fabiana Piscitelli, Hamid R Habibi, Vincenzo Di Marzo, Oliana Carnevali
DiNP (Di-isononyl phthalate) has been recently introduced as DEHP (Bis (2-ethylhexyl) phthalate) substitute and due to its chemical properties, DiNP is commonly used in a large variety of plastic items. The endocannabinoid system (ECS) is a lipid signaling system involved in a plethora of physiological pathways including the control of the reproductive and metabolic processes. In this study, the effects of DiNP on the ECS of zebrafish (male and female) gonads were analyzed. Adult zebrafish were chronically exposed for 21 days via water to 3 environmentally relevant concentrations of DiNP (42 μg/L; 4...
May 21, 2018: Environmental Pollution
Stephanie M Engel, Gro D Villanger, Rachel C Nethery, Cathrine Thomsen, Amrit K Sakhi, Samantha S M Drover, Jane A Hoppin, Pal Zeiner, Gun Peggy Knudsen, Ted Reichborn-Kjennerud, Amy H Herring, Heidi Aase
BACKGROUND: There is growing concern that phthalate exposures may have an impact on child neurodevelopment. Prenatal exposure to phthalates has been linked with externalizing behaviors and executive functioning defects suggestive of an attention-deficit hyperactivity disorder (ADHD) phenotype. OBJECTIVES: We undertook an investigation into whether prenatal exposure to phthalates was associated with clinically confirmed ADHD in a population-based nested case-control study of the Norwegian Mother and Child Cohort (MoBa) between the years 2003 and 2008...
May 10, 2018: Environmental Health Perspectives
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