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https://www.readbyqxmd.com/read/29458081/di-2-ethylhexyl-phthalate-dehp-alters-proliferation-and-uterine-gland-numbers-in-the-uteri-of-adult-exposed-mice
#1
Kadeem A Richardson, Patrick R Hannon, Yvette J Johnson-Walker, Maung Sun Myint, Jodi A Flaws, Romana A Nowak
Di-(2-ethylhexyl) phthalate (DEHP) is an endocrine-disrupting chemical that has been shown to impair normal reproductive function in males and females. This study investigated whether adult exposure to environmental and occupational doses of DEHP alters homeostasis of uterine proliferation, morphology, and number of uterine glands. Adult female CD1 mice were orally dosed with DEHP (0, 20 μg/kg/day, 200 μg/kg/day, 20 mg/kg/day or 200 mg/kg/day) for 30 days. Results indicated that DEHP at 200 μg/kg/day caused a reduction in epithelial cell proliferation in the uterus (p < ...
February 16, 2018: Reproductive Toxicology
https://www.readbyqxmd.com/read/29454883/obesity-or-diet-levels-and-determinants-of-phthalate-body-burden-a-case-study-on-portuguese-children
#2
Luísa Correia-Sá, Monika Kasper-Sonnenberg, Claudia Pälmke, André Schütze, Sónia Norberto, Conceição Calhau, Valentina F Domingues, Holger M Koch
In this study we analyzed one of the most comprehensive sets of 21 urinary phthalate metabolites representing exposure to 11 parent phthalates (DEP, DMP, DiBP, DnBP, BBzP, DEHP, DiNP, DiDP, DCHP, DnPeP, DnOP) in first morning urine samples of 112 Portuguese children (4-18 years) sampled in 2014/15. The study population consisted of two groups: group 1 with normal weight/underweight children (N = 43) following their regular diet and group 2 with obese/overweight children (N = 69) following a healthy diet (with nutritional counselling)...
February 6, 2018: International Journal of Hygiene and Environmental Health
https://www.readbyqxmd.com/read/29446939/particle-gas-partitioning-of-phthalates-to-organic-and-inorganic-airborne-particles-in-the-indoor-environment
#3
Yaoxing Wu, Clara M A Eichler, Jianping Cao, Jennifer L Benning, Amy Olson, Shengyang Chen, Cong Liu, Eric Warren Vejerano, Linsey C Marr, John C Little
The particle/gas partition coefficient Kp is an important parameter affecting the fate and transport of indoor semi-volatile organic compounds (SVOCs) and resulting human exposure. Unfortunately, experimental measurements of Kp exist almost exclusively for atmospheric polycyclic aromatic hydrocarbons (PAHs), with very few studies focusing on SVOCs that occur in indoor environments. A specially-designed tube chamber operating in the laminar flow regime was developed to measure Kp of the plasticizer di-2-ethylhexyl phthalate (DEHP) for one inorganic (ammonium sulfate) and two organic (oleic acid and squalane) particles...
February 15, 2018: Environmental Science & Technology
https://www.readbyqxmd.com/read/29427905/gc-ms-determination-of-phthalate-esters-in-human-urine-a-potential-biomarker-for-phthalate-bio-monitoring
#4
Ramaswamy Babu-Rajendran, Gopalakrishnan Preethi, Rama Krishnan Poopal, Nishikant Patil Nikhil, Krishnamoorthi Vimalkumar, Annamalai Subramanian, Selvaraj Krishna-Kumar
Six phthalic acid esters (PAEs) in human urine sampled randomly from three districts (Erode, Thanjavur, and Perambalur) in Tamil Nadu State and a Union Territory (Pondicherry) in India were quantified. We determined gender-wise, age-wise and location-wise distribution of PAEs and measured estrogenic activity of urine by molecular docking. Bis(2‑ethylhexyl) phthalate (DEHP) was the predominant phthalic acid ester found and had a recovery of 104.5% (ultrasonic extraction at 15 min). Gender-wise (pregnant women: 185 ng/mL, children: 156 ng/mL, female: 151 ng/mL, and male: 138 ng/mL), age-wise (1-20 y: 157 ng/mL, 21-40 y: 156 ng/mL, and >40 y: 146 ng/mL), location-wise (urban: 154 ng/mL, and rural: 151 ng/mL), and region-wise (Erode district: 185 ng/mL, Thanjavur district: 155 ng/mL, Perambalur district: 117 ng/mL, and Pondicherry: 135 ng/mL) differences with total mean of Σ6 PAEs were found...
February 2, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29427707/assessment-of-endocrine-disruption-and-oxidative-potential-of-bisphenol-a-triclosan-nonylphenol-diethylhexyl-phthalate-galaxolide-and-carbamazepine-common-contaminants-of-municipal-biosolids
#5
Jo-Anne E Cavanagh, Katherine Trought, Caroline Mitchell, Grant Northcott, Louis A Tremblay
The use of biosolids as a soil conditioner and fertiliser is hindered by the limited knowledge on the risks of micro-contaminants they contain. This study investigated the binding of six organic contaminants commonly found in biosolids, to the estrogen (ER), androgen (AR), aryl hydrocarbon (AhR), and transthyretin (TTR) receptors and their redox activity. Triclosan (TCS), bisphenol-A (BPA), and technical nonylphenol (TNP) had affinity for the TTR with relative potencies of 0.3, 0.03, and 0.076 respectively...
February 7, 2018: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/29426135/phthalates-and-polycyclic-aromatic-hydrocarbons-pahs-in-the-indoor-settled-carpet-dust-of-mosques-health-risk-assessment-for-public
#6
Mohammad W Kadi, Nadeem Ali, Hussain Mohammed Salem Ali Albar
A number of studies have reported the occurrence of phthalates and polycyclic aromatic hydrocarbons (PAHs) in indoor settled dust from different occupational and residential settings around the world but limited studies are available from public and religious places. In recent decades Kingdom of Saudi Arabia (KSA) has experienced tremendous industrial growth especially in the petroleum industries, and as result environmental issues related with such industries have also increased but scientific data is still scarce to understand the impact on public health...
January 29, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29421747/degradation-of-di-2-ethylhexyl-phthalate-in-sediment-by-a-surfactant-enhanced-fenton-like-process
#7
Meihua Zhao, Min Cheng, Guangming Zeng, Chaosheng Zhang
This is the premier study reporting the remediation of di (2-ethylhexyl) phthalate (DEHP) contaminated sediment by a surfactant-enhanced Fenton-like system. Three widely used non-ionic surfactants were tested, and the order for desorption and solubilization of DEHP was determined as Tween 80 > Triton X-100 > Brij 35. The degradation of DEHP was studied at a near natural pH of 6.0 by two Fenton treatments: (i) Fe3+/H2O2 and (ii) Fe3+/PCA/H2O2. Results show that the addition of PCA can significantly enhance DEHP removal from 48...
February 3, 2018: Chemosphere
https://www.readbyqxmd.com/read/29421411/excretion-of-di-2-ethylhexyl-phthalate-dehp-metabolites-in-urine-is-related-to-body-mass-index-because-of-higher-energy-intake-in-the-overweight-and-obese
#8
Jerry L Campbell, Miyoung Yoon, Peyton L Ward, Hermann Fromme, Winfried Kessler, Martin B Phillips, Warwick A Anderson, Harvey J Clewell, Matthew P Longnecker
A higher body mass index (BMI) has been positively associated with the rate of excretion of di-2-ethylhexyl phthalate (DEHP) metabolites in urine in data from the National Health and Nutrition Examination Survey (NHANES), suggesting an association between DEHP exposure and BMI. The association, however, may be due to the association between body mass maintenance and higher energy intake, with higher energy intake being accompanied by a higher intake of DEHP. To examine this hypothesis, we ran a Monte Carlo simulation with a DEHP physiologically-based pharmacokinetic (PBPK) model for adult humans...
January 31, 2018: Environment International
https://www.readbyqxmd.com/read/29421333/the-urinary-metabolites-of-dinch%C3%A2-have-an-impact-on-the-activities-of-the-human-nuclear-receptors-er%C3%AE-er%C3%AE-ar-ppar%C3%AE-and-ppar%C3%AE
#9
Anika Engel, Thorsten Buhrke, Stefanie Kasper, Anne-Cathrin Behr, Albert Braeuning, Sönke Jessel, Albrecht Seidel, Wolfgang Völkel, Alfonso Lampen
DINCH® (di-isononyl cyclohexane-1,2-dicarboxylate) is a non-phthalate plasticizer that has been developed to replace phthalate plasticizers such as DEHP (di-2-ethylhexyl phthalate) or DINP (di-isononyl phthalate). DINCH® is metabolized to its corresponding monoester and subsequently to oxidized monoester derivatives. These are conjugated to glucuronic acid and subject to urinary excretion. In contrast to DINCH®, there are almost no toxicological data available regarding its primary and secondary metabolites...
February 5, 2018: Toxicology Letters
https://www.readbyqxmd.com/read/29421094/impact-of-two-plastic-derived-chemicals-the-bisphenol-a-and-the-di-2-ethylhexyl-phthalate-exposure-on-the-marine-toxic-dinoflagellate-alexandrium-pacificum
#10
Charaf M'Rabet, Olivier Pringault, Habiba Zmerli-Triki, Héla Ben Gharbia, Douglas Couet, Ons Kéfi-Daly Yahia
The effects of two plastic-derived chemicals: Bisphenol A (BPA) and di-2-ethylhexyl phthalate (DEHP) were assessed on abundance and physiological responses of the marine toxic dinoflagellate Alexandrim pacificum. During 7days experiment, A. pacificum was exposed to different levels of BPA and DEHP (separately and in mixture). The responses were evaluated and compared with controls. Results showed that A. pacificum was highly sensitive to this contaminants comparing to other phytoplankton species. BPA and DEHP caused the decrease of the biomass (1...
January 2018: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/29407759/endotoxin-enhances-respiratory-effects-of-phthalates-in-adults-results-from-nhanes-2005-6
#11
Paula D Strassle, Lidwien A M Smit, Jane A Hoppin
Phthalates have been associated with respiratory symptoms in adults; they may enhance effects of inflammatory compounds. To assess the potential interactions of phthalates and endotoxin on respiratory and allergic symptoms in adults, we used cross-sectional information from the 1091 adults with complete data on urinary phthalates and house dust endotoxin from NHANES 2005-2006. We used multivariable logistic regression to assess whether endotoxin levels modified the association between nine phthalate metabolites and four current allergic symptoms (asthma, wheeze, hay fever, and rhinitis)...
February 1, 2018: Environmental Research
https://www.readbyqxmd.com/read/29400129/development-and-characterization-of-a-synthetic-pvc-dehp-myocardial-tissue-analogue-material-for-ct-imaging-applications
#12
Sherif Ramadan, Narinder Paul, Hani E Naguib
A simple myocardial analogue material has great potential to help researchers in the creation of medical CT Imaging phantoms. This work aims to outline a Bis(2-ethylhexyl) phthalate (DEHP) plasticizer/PVC material to achieve this. DEHP-PVC was manufactured in three ratios, 75%, 80%, and 85% DEHP by heating at 110°C for 10 minutes to promote DEHP-PVC binding followed by heating at 150°C to melt the blend. The material was then tested utilizing FTIR, tensile testing, dynamic mechanical analysis and imaged with computed tomography...
February 5, 2018: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/29391432/systems-analysis-of-the-liver-transcriptome-in-adult-male-zebrafish-exposed-to-the-plasticizer-2-ethylhexyl-phthalate-dehp
#13
Matthew Huff, Willian A da Silveira, Oliana Carnevali, Ludivine Renaud, Gary Hardiman
The organic compound diethylhexyl phthalate (DEHP) represents a high production volume chemical found in cosmetics, personal care products, laundry detergents, and household items. DEHP, along with other phthalates causes endocrine disruption in males. Exposure to endocrine disrupting chemicals has been linked to the development of several adverse health outcomes with apical end points including Non-Alcoholic Fatty Liver Disease (NAFLD). This study examined the adult male zebrafish (Danio rerio) transcriptome after exposure to environmental levels of DEHP and 17α-ethinylestradiol (EE2) using both DNA microarray and RNA-sequencing technologies...
February 1, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29390543/the-risk-of-missed-abortion-associated-with-the-levels-of-tobacco-heavy-metals-and-phthalate-in-hair-of-pregnant-woman-a-case-control-study-in-chinese-women
#14
Ranran Zhao, Yuelian Wu, Fangfang Zhao, Yingnan Lv, Damin Huang, Jinlian Wei, Chong Ruan, Mingli Huang, Jinghuan Deng, Dongping Huang, Xiaoqiang Qiu
To assess the association between exposure to the tobacco, heavy metals and phthalate on early pregnancy and missed abortion.42 women with missed abortion and 57 matched controls (women with normal pregnancies) were recruited between March and May 2012, from the Department of Gynecology and Obstetrics, First Affiliated Hospital of Guangxi Medical University and the People Hospital of Guangxi Zhuang Autonomous Region. The questionnaire survey was carried on to learn about the basic conditions, as well as smoking history of all participants...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29385306/di-2-ethylhexyl-phthalate-dehp-influences-follicular-development-in-mice-between-the-weaning-period-and-maturity-by-interfering-with-ovarian-development-factors-and-micrornas
#15
Jin Liu, Wenxiang Wang, Jianlin Zhu, Yuchen Li, Lingfeng Luo, Yuanyuan Huang, Wenchang Zhang
Although studies have shown that di(2-ethylhexyl) phthalate (DEHP) can disrupt ovarian function, few reports have focused on follicular development in mice between the weaning period and maturity, especially with respect to microRNA (miRNA) expression. In this study, 21-day-old ICR mice were administered DEHP at doses of 0, 100, 400, and 1600 mg/(kg d) for 6 weeks by gavage. After DEHP administration, a significant decrease in the expression of follicle development-related factors (including c-kit, kitl, gdf9, and atm) was observed by quantitative real-time PCR (RT-PCR), but no significant difference in the proteins encoded by these genes was observed by Western blot...
January 31, 2018: Environmental Toxicology
https://www.readbyqxmd.com/read/29385277/prenatal-phthalate-exposure-was-associated-with-croup-in-swedish-infants
#16
Huan Shu, Sverre Wikstrom, Bo Ag Jönsson, Christian H Lindh, Åke Svensson, Eewa Nånberg, Carl-Gustaf Bornehag
AIM: This study examined whether prenatal phthalate exposure was associated with lower or upper airway inflammation in infants. METHODS: From 2007-2010 we used liquid chromatography tandem mass spectrometry, adjusted for creatinine, to analyse 14 phthalate metabolites and one phthalate replacement in the urine of 1,062 Swedish mothers at a median of 10 weeks of pregnancy. This was used to determine any associations between prenatal phthalate exposure and croup, wheezing or otitis in their offspring until 12 months of age, using logistic regression, adjusted for potential confounders...
January 31, 2018: Acta Paediatrica
https://www.readbyqxmd.com/read/29377175/the-effect-of-maternal-exposure-to-di-2-ethylhexyl-phthalate-on-fetal-cardiac-development-in-mice
#17
Changqing Tang, Yuxin Deng, Hongyu Duan, Yi Zhang, Yifei Li, Dajian Qiu, Kaiyu Zhou, Yimin Hua, Chuan Wang
Accumulating evidence has suggested a link between maternal di-(2-ethylhexyl)-phthalate (DEHP) exposure and various developmental abnormalities. However, the evidence regarding the effect of maternal DEHP exposure on fetal cardiac development is scarce. The present study aimed to determine the effect of maternal DEHP exposure on fetal cardiac development in mice and explore the possible involved mechanism preliminarily. The C57BL mice were randomly divided into four groups: the vehicle group (corn oil, n = 10), 250 mg kg-1 DEHP group (n = 15), 500 mg kg-1 DEHP group (n = 20) and 1 g kg-1 DEHP group (n = 20)...
January 26, 2018: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/29373650/melatonin-protects-oocytes-from-mehp-exposure-induced-meiosis-defects-in-porcine
#18
Zhang Yu, Teng Wang, Mei Lan, Xin-Wei Zang, Yi-Lun Li, Xiang-Shun Cui, Nam-Hyung Kim, Shao-Chen Sun
In 2011, DEHP (plasticizer) was reported to illegally be added in food and beverage products in Taiwan, which caused great concerns about food safety worldwide. DHEP has multiple toxic effects to human and animals like endocrine disruption, cardiotoxicity, reproductive function and development defects. However, the toxic effects of DEHP on mammalian oocyte quality are still unclear. Since MEHP is the active metabolite of DEHP in vivo, in present study we used porcine oocyte as model to explore the effects of MEHP on oocyte maturation and we also studied the effects of melatonin administration on MEHP exposure-induced meiosis defects...
January 2, 2018: Biology of Reproduction
https://www.readbyqxmd.com/read/29367177/association-between-fetal-exposure-to-phthalate-endocrine-disruptor-and-genome-wide-dna-methylation-at-birth
#19
Chung-Hsing Chen, Shih Sheng Jiang, I-Shou Chang, Hui-Ju Wen, Chien-Wen Sun, Shu-Li Wang
BACKGROUND: Phthalic acid esters are ubiquitous and antiandrogenic, and may cause systemic effects in humans, particularly with in utero exposure. Epigenetic modification, such as DNA methylation, has been hypothesized to be an important mechanism that mediates certain biological processes and pathogenic effects of in utero phthalate exposure. OBJECTIVE: The aim of this study was to examine the association between genome-wide DNA methylation at birth and prenatal exposure to phthalate...
January 19, 2018: Environmental Research
https://www.readbyqxmd.com/read/29351545/love-song-blues-dehp-alters-courtship-vocalizations-in-mice
#20
Nate Seltenrich
No abstract text is available yet for this article.
January 17, 2018: Environmental Health Perspectives
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