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https://www.readbyqxmd.com/read/27919640/the-french-human-biomonitoring-program-first-lessons-from-the-perinatal-component-and-future-needs
#1
Clémentine Dereumeaux, Clémence Fillol, Marie-Aline Charles, Sébastien Denys
This paper presents a progress report of the French human biomonitoring (HBM) program established in 2010. This program has been designed to provide a national representative estimation of the French population's exposure to various environmental chemicals and to study the determinants of exposure. This program currently consists in two surveys: a perinatal component related to a selection of 4145 pregnant women who have been enrolled in the Elfe cohort (the French Longitudinal Study since Childhood) in 2011, and a general population survey related to adults aged 18-74 years and children as from 6 years (Esteban)...
November 17, 2016: International Journal of Hygiene and Environmental Health
https://www.readbyqxmd.com/read/27907809/does-exposure-to-phthalates-influence-thyroid-function-and-growth-hormone-homeostasis-the-taiwan-environmental-survey-for-toxicants-test-2013
#2
Han-Bin Huang, Wen-Harn Pan, Jung-Wei Chang, Hung-Che Chiang, Yue Leon Guo, Jouni J K Jaakkola, Po-Chin Huang
BACKGROUND: Previous epidemiologic and toxicological studies provide some inconsistent evidence that exposure to phthalates may affect thyroid function and growth hormone homeostasis. OBJECTIVE: To assess the relations between exposure to phthalates and indicators of thyroid function and growth hormone homeostasis disturbances both among adults and minors. METHODS: We conducted a population-based cross-sectional study of 279 Taiwanese adults (≥18 years old) and 79 minors (<18 years old) in 2013...
November 28, 2016: Environmental Research
https://www.readbyqxmd.com/read/27863867/prenatal-di-2-ethylhexyl-phthalate-exposure-and-cord-blood-adipokine-levels-and-birth-size-the-hokkaido-study-on-environment-and-children-s-health
#3
Machiko Minatoya, Atsuko Araki, Chihiro Miyashita, Seiko Sasaki, Yuko Goto, Tamie Nakajima, Reiko Kishi
Di-2-ethylhexyl phthalate (DEHP) is one of the most widely used phthalates. Metabolites of DEHP are detectable in majority of the population. Findings on adverse health outcomes, particularly birth weight in association with prenatal exposure to DEHP remain equivocal. Besides, there is insufficient evidence to address influence on metabolic function from epidemiological studies. Thus, our objective was to investigate cord blood adipokine levels and birth size in association with prenatal DEHP exposure in prospective birth cohort study...
November 15, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/27863804/phthalate-metabolites-in-24-h-urine-samples-of-the-german-environmental-specimen-bank-esb-from-1988-to-2015-and-a-comparison-with-us-nhanes-data-from-1999-to-2012
#4
Holger M Koch, Maria Rüther, André Schütze, André Conrad, Claudia Pälmke, Petra Apel, Thomas Brüning, Marike Kolossa-Gehring
The German Environmental Specimen Bank (ESB) continuously collects 24-h urine samples since the early 1980s in Germany. In this study we analyzed 300 urine samples from the years 2007 to 2015 for 21 phthalate metabolites (representing exposure to 11 parent phthalates) and combined the data with two previous retrospective measurement campaigns (1988 to 2003 and 2002 to 2008). The combined dataset comprised 1162 24-h urine samples spanning the years 1988 to 2015. With this detailed set of human biomonitoring data we describe the time course of phthalate exposure in Germany over a time frame of 27 years...
November 9, 2016: International Journal of Hygiene and Environmental Health
https://www.readbyqxmd.com/read/27859543/chemical-activity-based-environmental-risk-analysis-of-the-plasticizer-di-ethylhexyl-phthalate-and-its-main-metabolite-mono-ethylhexyl-phthalate
#5
Frank A P C Gobas, S Victoria Otton, Laura F Tupper-Ring, Meara A Crawford, Kathryn E Clark, Michael G Ikonomou
This study applies a chemical activity-based approach to (i) evaluate environmental concentrations of di-ethylhexyl phthalate (DEHP) (n = 23,651) and its metabolite mono-ethylhexyl phthalate (MEHP) (n = 1,232) in 16 environmental media from 1,174 studies in the United States, Canada, Europe and Asia, and in-vivo toxicity data from 934 studies in 20 species as well as in-vitro biological activity data from USEPA's Toxicity Forecaster (ToxCast) and other sources; and (ii) conduct a comprehensive environmental risk analysis...
November 17, 2016: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/27854062/determination-of-pesticide-and-phthalate-residues-in-tea-by-quechers-method-and-their-fate-in-processing
#6
Sapna Yadav, Satyajeet Rai, Ashutosh K Srivastava, Smita Panchal, D K Patel, V P Sharma, Sudha Jain, L P Srivastava
In this study, the quick, easy, cheap, effective, rugged, and safe (QuEChERS) method was applied for the analysis of the multiclass pesticide residues of 12 organochlorines (OCs), 9 organophosphates (OPs), 11 synthetic pyrethroids (SPs), 4 herbicides, 6 phthalates in raw tea (loose tea, branded tea and herbal tea), and tea infusion in 4 different containers (glass cup, earthen cup, plastic bag and disposal cup). In loose tea and branded tea residues, malathion (0.257 and 0.118 mg kg(-1)), cypermethrin (0...
November 17, 2016: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/27849367/fetal-exposure-to-low-levels-of-the-plasticizer-dehp-predisposes-the-adult-male-adrenal-gland-for-endocrine-disruption
#7
S Lee, D B Martinez-Arguelles, E Campioli, V Papadopoulos
In utero exposure to endocrine disrupting chemicals (EDCs) may affect adult health. Di-(2-ethylhexyl) phthalate (DEHP) is an EDC widely used in the production of polyvinyl chloride products and an ubiquitous environmental contaminant. Previously, we used a rat model system to show that fetal exposure to DEHP decreased levels of major steroid hormones in adulthood and that environmentally-relevant levels of DEHP affected both gene expression and epigenomic loci that were affected by exposure to high levels. In the adrenal gland, we reported that the peroxisome proliferator-activated receptor (PPAR) and cholesterol biosynthesis pathways were sensitive targets of DEHP...
November 16, 2016: Endocrinology
https://www.readbyqxmd.com/read/27847230/fate-of-emerging-and-priority-micropollutants-during-the-sewage-sludge-treatment-case-study-of-paris-conurbation-part-1-contamination-of-the-different-types-of-sewage-sludge
#8
R Mailler, J Gasperi, D Patureau, E Vulliet, N Delgenes, A Danel, S Deshayes, V Eudes, S Guerin, R Moilleron, G Chebbo, V Rocher
This article provides data on the contamination of different kinds of sludge (raw, centrifuged, digested, thermally dried sludge and sludge cake) from Paris conurbation by 71 various pollutants including pharmaceutical products (PHPs), hormones, perfluorinated acids (PFAs), linear alkylbenzene sulfonate (LAS), alkylphenols (APs), phthalates (PAEs), polycyclic aromatic hydrocarbons (PAHs) and polychlorobiphenyls (PCBs). Very high contents of LAS (0.1-10g/kg dry matter - DM) compared to other compounds were found in all types of sludge followed by DEHP (10-100mg/kg DM) and fluoroquinolones (1-100mg/kg DM)...
November 12, 2016: Waste Management
https://www.readbyqxmd.com/read/27845755/effects-of-di-2-ethylhexyl-phthalate-on-the-hypothalamus-uterus-in-pubertal-female-rats
#9
Te Liu, Yiyang Jia, Liting Zhou, Qi Wang, Di Sun, Jin Xu, Juan Wu, Huaiji Chen, Feng Xu, Lin Ye
The pollution of endocrine disruptors and its impact on human reproductive system have attracted much attention. Di-(2-ethylhexyl) phthalate (DEHP), an environmental endocrine disruptor, is widely used in food packages, containers, medical supplies and children's toys. It can cause diseases such as infertility, sexual precocity and uterine bleeding and thus arouse concerns from the society and scholars. The effect of DEHP on pubertal female reproductive system is still not well-studied. This study was to investigate the effects of DEHP on the hypothalamus-uterus in pubertal female rats, reveal the reproductive toxicity of DEHP on pubertal female rats and its mechanism, and provide scientific evidence for the evaluation of toxicity and toxic mechanism of DEHP on reproductive system...
November 12, 2016: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/27836348/assessing-the-concentration-of-phthalate-esters-paes-and-bisphenol-a-bpa-and-the-genotoxic-potential-of-treated-wastewater-final-effluent-in-saudi-arabia
#10
Iman Al-Saleh, Rola Elkhatib, Tahreer Al-Rajoudi, Ghofran Al-Qudaihi
Plasticizers such as phthalate esters (PAEs) and bisphenol A (BPA) are highly persistent organic pollutants that tend to bio-accumulate in humans through the soil-plant-animal food chain. Some studies have reported the potential carcinogenic and teratogenic effects in addition to their estrogenic activities. Water resources are scarce in Saudi Arabia, and several wastewater treatment plants (WTPs) have been constructed for agricultural and industrial use. This study was designed to: (1) measure the concentrations of BPA and six PAEs, dimethyl phthalate (DMP), diethyl phthalate (DEP), dibutyl phthalate (DBP), butyl benzyl phthalate (BBP), bis (2-ethylhexyl) phthalate (DEHP) and dioctyl phthalate (DOP), in secondary- and tertiary-treated wastewater collected from five WTPs in three Saudi cities for four to five weeks and (2) test their potential genotoxicity...
November 8, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/27827939/effects-of-di-2-ethylhexyl-phthalate-on-lipid-metabolism-by-the-jak-stat-pathway-in-rats
#11
Yiyang Jia, Te Liu, Liting Zhou, Jian Zhu, Juan Wu, Di Sun, Jin Xu, Qi Wang, Huaiji Chen, Feng Xu, Yuezhu Zhang, Tianrong Zhang, Hongbo Liu, Lin Ye
The most widely used plasticizer, di-(2-ethylhexyl) phthalate (DEHP), is known to affect lipid metabolism and adipogenesis. We studied the effects of dietary DEHP exposure on metabolism in rats as well as the role of the JAK/STAT pathway in this process. Eighty rats were exposed to DEHP (0, 5, 50 and 500 mg/kg/d) through dietary intake for 4 weeks. We then collected blood samples, liver, and adipose tissues to detect modifications in the levels of serum lipids, leptin, adiponectin and insulin. JAK3, STAT5a and PPARγ expression were detected at both the gene and protein levels...
November 4, 2016: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/27825933/comparative-toxicity-oxidative-stress-and-endocrine-disruption-potential-of-plasticizers-in-jeg-3-human-placental-cells
#12
Elisabet Pérez-Albaladejo, Denise Fernandes, Silvia Lacorte, Cinta Porte
Plasticizers are suspected to be toxic and/or to modulate or disrupt the endocrine system of humans and to cross the placental barrier, being embryonic and fetal development a particularly vulnerable period. This work investigates the comparative toxicity and ability to interfere with the synthesis of steroids and to generate reactive oxygen species (ROS) of a selected number of plasticizers, including bisphenol A (BPA), nonyl- (NP) and octylphenol (OP), benzyl butyl phthalate (BBP), dibutyl phthalate (DBP), di(2-ethylhexyl)phthalate (DEHP) and dimethyl phthalate (DMP), in the human placenta JEG-3 cells...
November 4, 2016: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/27822646/identification-and-quantification-by-1-h-nuclear-magnetic-resonance-spectroscopy-of-seven-plasticizers-in-pvc-medical-devices
#13
Stéphanie Genay, Frédéric Feutry, Morgane Masse, Christine Barthélémy, Valérie Sautou, Pascal Odou, Bertrand Décaudin, Nathalie Azaroual
Medical devices are generally made of polyvinyl chloride plasticized by six authorized plasticizers as alternatives to di-(2-ethylhexyl)-phthalate (DEHP) classified as reprotoxic class 1b. These are acetyl tri-n-butyl citrate (ATBC), di-(2-ethylhexy) adipate (DEHA), di-(2-ethylhexyl) terephthalate (DEHT), di-isononyl cyclohexane-1,2-dicarboxylate (DINCH), di-isononyl phthalate (DINP), and tri-octyl trimellitate (TOTM). The main objective of this study was to propose a new method using (1)H NMR spectroscopy to determine and quantify these seven plasticizers in PVC sheets, standard infusion tubings, and commercially available medical devices...
November 7, 2016: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/27794206/molecular-mechanism-of-microrna-200c-regulating-transforming-growth-factor-%C3%AE-tgf-%C3%AE-smad-family-member-3-smad3-pathway-by-targeting-zinc-finger-e-box-binding-homeobox-1-zeb1-in-hypospadias-in-rats
#14
Chong Qian, Xiangyang Dang, Xianglin Wang, Wei Xu, Guijian Pang, Yifeng Chen, Chengbei Liu
BACKGROUND The aim of this study was to explore effects of microRNA-200c regulating TGF-β/Smad3 pathway by targeting Zeb1 on the occurrence and development of hypospadias and to evaluate the relationship between microRNA-200c and occurrence of hypospadias. MATERIAL AND METHODS Pregnant rats with a gestational age of 12 days were allocated into 2 groups; one received gavage of DEHP-contained soybean oil (1 ml/day, 8 days; Group A) and the other had gavage of normal soybean oil (1 ml/day, 8 days; Group B). Baby rats with hypospadias from Group A were assigned to the model group (n=20) and healthy baby rats from Group B were assigned to the control group (n=20)...
October 29, 2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/27788447/predicting-the-gas-phase-concentration-of-semi-volatile-organic-compounds-from-airborne-particles-application-to-a-french-nationwide-survey
#15
Wenjuan Wei, Corinne Mandin, Olivier Blanchard, Fabien Mercier, Maud Pelletier, Barbara Le Bot, Philippe Glorennec, Olivier Ramalho
Semi-volatile organic compounds (SVOCs) partition indoors between the gas phase, airborne particles, settled dust, and other surfaces. Unknown concentrations of SVOCs in the gas phase (Cg) can be predicted from their measured concentrations in airborne particles. In previous studies, the prediction of Cg depended largely on choosing a specific equation for the calculation of the particle/gas partition coefficient. Moreover, the prediction of Cg is frequently performed at a reference temperature rather than the real indoor temperature...
October 24, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/27771571/environmental-exposure-to-human-carcinogens-in-teenagers-and-the-association-with-dna-damage
#16
Carmen Franken, Gudrun Koppen, Nathalie Lambrechts, Eva Govarts, Liesbeth Bruckers, Elly Den Hond, Ilse Loots, Vera Nelen, Isabelle Sioen, Tim S Nawrot, Willy Baeyens, Nicolas Van Larebeke, Francis Boonen, Daniëlla Ooms, Mai Wevers, Griet Jacobs, Adrian Covaci, Thomas Schettgen, Greet Schoeters
BACKGROUND: We investigated whether human environmental exposure to chemicals that are labeled as (potential) carcinogens leads to increased (oxidative) damage to DNA in adolescents. MATERIAL AND METHODS: Six hundred 14-15-year-old youngsters were recruited all over Flanders (Belgium) and in two areas with important industrial activities. DNA damage was assessed by alkaline and formamidopyrimidine DNA glycosylase (Fpg) modified comet assays in peripheral blood cells and analysis of urinary 8-hydroxydeoxyguanosine (8-OHdG) levels...
January 2017: Environmental Research
https://www.readbyqxmd.com/read/27750193/long-term-exposure-assessment-to-phthalates-how-do-nail-analyses-compare-to-commonly-used-measurements-in-urine
#17
Andreia Alves, Gudrun Koppen, Guido Vanermen, Adrian Covaci, Stefan Voorspoels
Phthalate esters (PEs) are easily metabolized and commonly excreted via urine within 24h, therefore their bioaccumulation potential is thought to be rather low. In the present study, we developed a sample preparation combined with a new microextraction method to measure seven PE metabolites in nails. The use of whole nails did not result in significantly different levels compared to powdered nails, which makes the method very fast and user friendly. The method was validated using whole nails showing good accuracy, satisfactory precision and low limits of quantification (2-14ng/g)...
September 28, 2016: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/27736685/higher-moisture-content-is-associated-with-greater-emissions-of-dehp-from-pvc-wallpaper
#18
Nai-Yun Hsu, Yu-Chun Liu, Chia-Wei Lee, Ching-Chang Lee, Huey-Jen Su
Water damage and moisture in buildings may become more prevalent due to the increasing frequency of extreme precipitation and flooding events resulting from climate change. However, the effects of moisture levels on phthalate emissions from building materials are still underreported. This study aims to evaluate the effect of moisture content (MC) on the level of di-(2ethylhexyl) phthalate (DEHP) emitted from plastic wallpaper (0.22wt% DEHP) within 15 days in a closed chamber. A scenario of short-term exposure to DEHP in buildings suffering from water damage was simulated...
January 2017: Environmental Research
https://www.readbyqxmd.com/read/27719669/endocrine-disruption-in-silico-perspectives-of-interactions-of-di-2-ethylhexyl-phthalate-and-its-five-major-metabolites-with-progesterone-receptor
#19
Ishfaq A Sheikh, Muhammad Abu-Elmagd, Rola F Turki, Ghazi A Damanhouri, Mohd A Beg, Mohammed Al-Qahtani
BACKGROUND: Di-(2-ethylhexyl)phthalate (DEHP) is a common endocrine disrupting compound (EDC) present in the environment as a result of industrial activity and leaching from polyvinyl products. DEHP is used as a plasticizer in medical devices and many commercial and household items. Exposure occurs through inhalation, ingestion, and skin contact. DEHP is metabolized to a primary metabolite mono-(2-ethylhexyl)phthalate (MEHP) in the body, which is further metabolized to four major secondary metabolites, mono(2-ethyl-5-hydroxyhexyl)phthalate (5-OH-MEHP), mono(2-ethyl-5-oxyhexyl)phthalate (5-oxo-MEHP), mono(2-ethyl-5-carboxypentyl)phthalate (5-cx-MEPP) and mono[2-(carboxymethyl)hexyl]phthalate (2-cx-MMHP)...
September 30, 2016: BMC Structural Biology
https://www.readbyqxmd.com/read/27719622/phthalates-in-plastic-bottled-non-alcoholic-beverages-from-china-and-estimated-dietary-exposure-in-adults
#20
Ji-Feng Yang, Li-Ming Yang, Li-Ying Zheng, Guang-Guo Ying, Cheng-Bin Liu, Sheng-Lian Luo
Concentrations of six phthalates were determined in 69 plastic bottled non-alcoholic beverages collected from marketplaces in China. Di-n-butyl phthalate (DBP) and Di- (2-ethylhexyl)-phthalate (DEHP) were the most detected compounds with frequencies of 100%. Dimethyl phthalate (DMP) was found less, with a mean frequency of almost 34%. The samples were divided in 7 groups. The frequencies of phthalates in these groups ranged from 6.67 to 100%, which indicated that different types of beverages were differently contaminated by phthalates...
October 9, 2016: Food Additives & Contaminants. Part B, Surveillance
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