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https://www.readbyqxmd.com/read/28324030/early-prenatal-phthalate-exposure-sex-steroid-hormones-and-newborn-birth-outcomes
#1
Sheela Sathyanarayana, Samantha Butts, Christina Wang, Emily Barrett, Ruby Nguyen, Stephen M Schwartz, Wren Haaland, Shanna H Swan
Background: Adequate sex steroid hormone concentrations are essential for normal fetal genital development in early pregnancy. Our previous study demonstrated an inverse relationship between third trimester di-ethyl hexyl (DEHP) phthalate exposure and total testosterone (TT) concentrations. Here, we examine early pregnancy phthalates, sex steroid hormone concentrations, and newborn reproductive outcomes. Methods: We examined associations between urinary phthalate metabolite concentrations in early pregnancy and serum free testosterone (FT), TT, estrone (E1), and estradiol (E2) in 591 woman/infant dyads in The Infant Development and Environment Study; we also examined relationships between hormones and newborn genital outcomes using multiple regression models with covariate adjustment...
March 9, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28319143/toxicity-effects-of-di-2-ethylhexyl-phthalate-to-eisenia-fetida-at-enzyme-cellular-and-genetic-levels
#2
Tingting Ma, Wei Zhou, Li'ke Chen, Longhua Wu, Peter Christie, Haibo Zhang, Yongming Luo
Di-(2-ethylhexyl) phthalate (DEHP) is a dominant phthalic acid ester (PAE) that has aroused public concern due to its resistance to degradation and its toxicity as an endocrine-disrupting compound. Effects of different concentrations of DEHP on Eisenia fetida in spiked natural soil have been studied in the body of the earthworm by means of soil cultivation tests 7, 14, 21 and 28 days after exposure. The results indicated that, in general, superoxide dismutase (SOD) activity, malondialdehyde (MDA) content, metallothionein (MT) content, the expression of heat shock protein 70 (HSP 70) and all the tested geno-toxicity parameters are promoted as time elapses and with increasing concentration of DEHP...
2017: PloS One
https://www.readbyqxmd.com/read/28314884/exposure-to-di-2-ethylhexyl-terephthalate-in-a-convenience-sample-of-u-s-adults-from-2000-to-2016
#3
Manori J Silva, Lee-Yang Wong, Ella Samandar, James L Preau, Antonia M Calafat, Xiaoyun Ye
Di-2-ethylhexyl terephthalate (DEHTP), a structural isomer of di-2-ethylhexyl phthalate (DEHP), is a plasticizer used in a variety of commercial applications, but data on Americans' exposure to DEHTP do not exist. We investigated the exposure to DEHTP in a convenience group of U.S. adults by analyzing urine collected anonymously in 2000 (N = 44), 2009 (N = 61), 2011 (N = 81), 2013 (N = 92), and 2016 (N = 149) for two major DEHTP oxidative metabolites: mono-2-ethyl-5-carboxypentyl terephthalate (MECPTP) and mono-2-ethyl-5-hydroxyhexyl terephthalate (MEHHTP)...
March 17, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/28314431/fast-analysis-of-phthalates-in-freeze-dried-baby-foods-by-ultrasound-vortex-assisted-liquid-liquid-microextraction-coupled-with-gas-chromatography-ion-trap-mass-spectrometry
#4
Mario Vincenzo Russo, Pasquale Avino, Ivan Notardonato
This paper is focused on the determination of phthalates (PAEs), compounds "plausibly" endocrine disruptors, in baby food products by means of a method based on ultrasound-vortex-assisted liquid-liquid microextraction coupled with GC-IT/MS (UVALLME-GC-IT/MS). Particularly, the whole procedure allows the determination of six phthalates such as DMP, DEP, DBP, iBcEP, BBP and DEHP. After dissolution of 0.1g product sample and addition of anthracene as Internal Standard, 250μL of n-heptane are used as extraction solvent...
November 25, 2016: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28292620/in%C3%A2-vitro-effects-of-phthalate-esters-in-human-myometrial-and-leiomyoma-cells-and-increased-urinary-level-of-phthalate-metabolite-in-women-with-uterine-leiomyoma
#5
Jin Hee Kim, Sung Hoon Kim, Young Sang Oh, Hyo Jin Ihm, Hee Dong Chae, Chung-Hoon Kim, Byung Moon Kang
OBJECTIVE: To investigate the possible role of phthalate, a ubiquitous chemical used in consumer products, in the pathogenesis of uterine leiomyoma. DESIGN: Experimental and prospective case-control study using human samples. SETTING: University hospital. PATIENT(S): Fifty-three women with histologic evidence of uterine leiomyoma and 33 surgical controls without leiomyoma. INTERVENTION(S): Human myometrial and leiomyoma cells were treated with di-(2-thylhexyl)-phthalate (DEHP)...
March 11, 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28292012/up-regulation-of-il-6-is-involved-in-di-2-ethylhexyl-phthalate-dehp-induced-migration-and-invasion-of-non-small-cell-lung-cancer-nsclc-cells
#6
Yingyi Wang, Ming Zhao, Jieying Liu, Jianjiao Ni, Yuchen Jiao, Chunmei Bai
Di (2-ethylhexyl) phthalate (DEHP), which is widely used in polyvinyl chloride materials, can be easily accumulated into human body. Lung cancer cells can be directly exposed to DEHP via inhalation, however, the effects and related mechanisms of DEHP on the progression of non small cell lung cancer (NSCLC) were not illustrated. Our present study revealed that DEHP less than 10(-4)M had no significant effect on the proliferation of A549 or H1299 cells, while nanomolar DEHP can trigger the migration and invasion of NSCLC cells...
March 10, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28286118/maternal-exposure-to-di-2-ethylhexyl-phthalate-dehp-promotes-the-transgenerational-inheritance-of-adult-onset-reproductive-dysfunctions-through-the-female-germline-in-mice
#7
Paola Pocar, Nadia Fiandanese, Anna Berrini, Camillo Secchi, Vitaliano Borromeo
Endocrine disruptors (EDs) are compounds known to promote transgenerational inheritance of adult-onset disease in subsequent generations after maternal exposure during fetal gonadal development. This study was designed to establish whether gestational and lactational exposure to the plasticizer di(2-ethylhexyl)phthalate (DEHP) at environmental doses promotes transgenerational effects on reproductive health in female offspring, as adults, over three generations in the mouse. Gestating F0 mouse dams were exposed to 0, 0...
March 9, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/28284729/effects-of-di-2-ethylhexyl-phthalate-exposure-on-1-2-dimethyhydrazine-induced-colon-tumor-promotion-in-rats
#8
Hsin-Pao Chen, Min-Hsiung Pan, Yuan-Yi Chou, Chieh Sung, Kuo-Hsin Lee, Chung-Man Leung, Ping-Chi Hsu
Di(2-ethylhexyl)phthalate (DEHP) may cause carcinogenicity in the liver; however, few have detailed on the potential effects of DEHP exposure on colorectal cancer. Male Sprague-Dawley rats received i.p. injections of 1,2-dimethylhydrazine (DMH) once-a-week for the first 4 weeks, and rats in each group were treated with DEHP through oral gavage daily for either 7, 10 or 15 weeks; after which, all rats were euthanized and their colons were assessed (a) morphologically for aberrant crypt foci (ACF) or tumors, (b) cytologically for mitotic index (MI), and (c) immunohistochemically for the expression of β-catenin, cyclooygenase (COX)-2, vascular endothelial growth factor (VEGF), proliferating cell nuclear antigen (PCNA), cyclin D1, and c-myc...
March 8, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28284648/the-relative-risk-and-its-distribution-of-endocrine-disrupting-chemicals-pharmaceuticals-and-personal-care-products-to-freshwater-organisms-in-the-bohai-rim-china
#9
Meng Zhang, Yajuan Shi, Yonglong Lu, Andrew C Johnson, Suriyanarayanan Sarvajayakesavalu, Zhaoyang Liu, Chao Su, Yueqing Zhang, Monika D Juergens, Xiaowei Jin
In this study, the risks to aquatic organisms posed by 12 commonly detected pharmaceuticals and personal care products (PPCPs) and endocrine disrupting chemicals (EDCs) that are extensively used in Bohai coastal region of China were examined. These were linear alkylbenzene sulfonate (LAS), nonylphenol (NP), diethylhexyl phthalate (DEHP), norfloxacin (NOR), sulfamethoxazole (SMX), erythromycin (ERY), bisphenol A (BPA), ofloxacin (OFL), carbamazepine (CBZ), naproxen (NPX), atenolol (ATL) and metoprolol (MET)...
March 8, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28274486/phthalates-non-phthalate-plasticizers-and-bisphenols-in-swedish-preschool-dust-in-relation-to-children-s-exposure
#10
Kristin Larsson, Christian H Lindh, Bo Ag Jönsson, Georgios Giovanoulis, Momina Bibi, Matteo Bottai, Anna Bergström, Marika Berglund
Children are exposed to a wide range of chemicals in their everyday environments, including the preschool. In this study, we evaluated the levels of phthalates, non-phthalate plasticizers and bisphenols in dust from 100 Swedish preschools and identified important exposure factors in the indoor environment. In addition, children's total exposure to these chemicals was determined by urine analysis to investigate their relation with dust exposure, and to explore the time trends by comparing with children who provided urine fifteen years earlier...
March 5, 2017: Environment International
https://www.readbyqxmd.com/read/28263175/the-purified-vepoloxamer-prevents-haemolysis-in-42-day-stored-dehp-pvc-free-red-blood-cell-units
#11
Jose A Cancelas, Neeta Rugg, Shawnagay Nestheide, Sarah E Hill, R Martin Emanuele, Douglas S Mckenzie
BACKGROUND: Use of the plasticiser di(2-ethylhexyl) phthalate (DEHP) in polyvinyl chloride (PVC) blood bags poses a potential dilemma. The presence of DEHP in blood bags has been shown to be beneficial to red blood cells during storage by diminishing haemolysis. However, DEHP use in PVC may be carcinogenic or estrogenising. Vepoloxamer is a poloxamer with rheological and cytoprotective rheological properties and a favourable toxicity profile in clinical trials. We hypothesised that vepoloxamer may be sufficient to replace the plasticiser DEHP to prevent elevated haemolysis while conserving the biochemical and redox potential++ in RBCs stored for up to 42 days...
March 2017: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/28254163/human-biomonitoring-pilot-study-democophes-in-germany-contribution-to-a-harmonized-european-approach
#12
Gerda Schwedler, Margarete Seiwert, Ulrike Fiddicke, Sissy Ißleb, Jürgen Hölzer, Julia Nendza, Michael Wilhelm, Jürgen Wittsiepe, Holger M Koch, Birgit K Schindler, Thomas Göen, Jörg Hildebrand, Reinhard Joas, Anke Joas, Ludwine Casteleyn, Jürgen Angerer, Argelia Castano, Marta Esteban, Greet Schoeters, Elly Den Hond, Ovnair Sepai, Karen Exley, Louis Bloemen, Lisbeth E Knudsen, Marike Kolossa-Gehring
Human biomonitoring (HBM) is an effective tool to assess human exposure to environmental pollutants, but comparable HBM data in Europe are lacking. In order to expedite harmonization of HBM studies on a European scale, the twin projects COPHES (Consortium to Perform Human Biomonitoring on a European Scale) and DEMOCOPHES (Demonstration of a study to Coordinate and Perform Human Biomonitoring on a European Scale) were formed, comprising 35 partners from 27 European countries. In COPHES a research scheme and guidelines were developed to exemplarily measure in a pilot study mercury in hair, cadmium, cotinine and several phthalate metabolites in urine of 6-11year old children and their mothers in an urban and a rural region...
February 6, 2017: International Journal of Hygiene and Environmental Health
https://www.readbyqxmd.com/read/28199414/direct-and-transgenerational-effects-of-low-doses-of-perinatal-di-2-ethylhexyl-phthalate-dehp-on-social-behaviors-in-mice
#13
Kayla M Quinnies, Erin P Harris, Rodney W Snyder, Susan S Sumner, Emilie F Rissman
Di-(2-ethylhexyl) phthalate (DEHP) is an endocrine disrupting chemical commonly used as a plasticizer in medical equipment, food packaging, flooring, and children's toys. DEHP exposure during early development has been associated with adverse neurobehavioral outcomes in children. In animal models, early exposure to DEHP results in abnormal development of the reproductive system as well as altered behavior and neurodevelopment. Based on these data, we hypothesized that developmental exposure to DEHP would decrease social interactions and increase anxiety-like behaviors in mice in a dose-dependent manner, and that the effects would persist over generations...
2017: PloS One
https://www.readbyqxmd.com/read/28192093/the-roles-of-hippocampal-micrornas-in-response-to-acute-postnatal-exposure-to-di-2-ethylhexyl-phthalate-in-female-and-male-rats
#14
Bryan E Luu, Stuart R Green, Christine L Childers, Matthew R Holahan, Kenneth B Storey
Previous studies have shown that di(2-ethylhexyl) phthalate (DEHP) exposure impairs the normal development of pre- and post-synaptic elements of the male, but not female, rat hippocampus. While males seem to be vulnerable to the neurodevelopmental deficits resulting from DEHP exposure, females appear to show a protective response. The purpose of the present study was to characterize hippocampal microRNAs in female and male rats exposed to DEHP to assess whether any patterns emerged that would be consistent with vulnerability in males and resilience in females...
February 10, 2017: Neurotoxicology
https://www.readbyqxmd.com/read/28188053/exposure-of-portuguese-children-to-the-novel-non-phthalate-plasticizer-di-iso-nonyl-cyclohexane-1-2-dicarboxylate-dinch
#15
Luísa Correia-Sá, André Schütze, Sónia Norberto, Conceição Calhau, Valentina F Domingues, Holger M Koch
Di-(iso-nonyl)-cyclohexane-1,2-dicarboxylate (DINCH) is used as substitute for high molecular weight phthalate plasticizers such as di-(2-ethylhexyl) phthalate (DEHP) and di-(iso-nonyl) phthalate (DINP). Due to a rapid substitution process, we must assume omnipresent and increasing DINCH exposures. The aim of this study was to evaluate DINCH exposure in 112 children (4-18years old) from Portugal, divided in two groups: 1) normal-/underweight following the usual diet; and 2) obese/overweight but under strict nutritional guidance...
February 7, 2017: Environment International
https://www.readbyqxmd.com/read/28174045/urinary-concentrations-of-25-phthalate-metabolites-in-brazilian-children-and-their-association-with-oxidative-dna-damage
#16
Bruno A Rocha, Alexandros G Asimakopoulos, Fernando Barbosa, Kurunthachalam Kannan
Exposure of humans to phthalates has received considerable attention due to the ubiquitous occurrence and potential adverse health effects of these chemicals. Nevertheless, little is known about the exposure of the Brazilian population to phthalates. In this study, concentrations of 25 phthalate metabolites were determined in urine samples collected from 300 Brazilian children (6-14years old). Further, the association between urinary phthalate concentrations and a biomarker of oxidative stress, 8-hydroxy-2'-deoxyguanosine (8OHDG), was examined...
May 15, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28174042/phthalate-induced-oxidative-stress-and-association-with-asthma-related-airway-inflammation-in-adolescents
#17
Carmen Franken, Nathalie Lambrechts, Eva Govarts, Gudrun Koppen, Elly Den Hond, Daniëlla Ooms, Stefan Voorspoels, Liesbeth Bruckers, Ilse Loots, Vera Nelen, Isabelle Sioen, Tim S Nawrot, Willy Baeyens, Nicolas Van Larebeke, Greet Schoeters
BACKGROUND: In Belgium, around 8.5% of the children have asthmatic symptoms. Increased asthma risk in children has been reported in relation to exposure to phthalate plasticizers but the underlying mechanisms are largely unknown. AIM: The aim of this study was to identify if oxidative stress, assessed by excision of 8-hydroxydeoxyguanosine (8-OHdG) from damaged DNA, is an intermediate marker for the association between phthalate exposure and doctor-diagnosed asthma...
January 30, 2017: International Journal of Hygiene and Environmental Health
https://www.readbyqxmd.com/read/28171772/maternal-prenatal-urinary-phthalate-metabolite-concentrations-and-visual-recognition-memory-among-infants-at-27-weeks
#18
Khristina N Ipapo, Pam Factor-Litvak, Robin M Whyatt, Antonia M Calafat, Diurka Diaz, Frederica Perera, Virginia Rauh, Julie B Herbstman
BACKGROUND: Prior research has demonstrated inverse associations between maternal prenatal urinary phthalate metabolite concentrations and cognitive development assessed in preschool and school-aged children. While there are a limited number of studies that evaluated these associations during infancy, no study has evaluated whether these associations exist when using the Fagan Test of Infant Intelligence (FTII), which captures novelty preference as a function of visual recognition memory...
February 4, 2017: Environmental Research
https://www.readbyqxmd.com/read/28166271/transcriptional-deregulation-of-genetic-biomarkers-in-chironomus-riparius-larvae-exposed-to-ecologically-relevant-concentrations-of-di-2-ethylhexyl-phthalate-dehp
#19
Óscar Herrero, Gloria Morcillo, Rosario Planelló
Di(2-ethylhexyl) phthalate (DEHP) is a ubiquitous environmental pollutant used worldwide as a plasticizer and solvent in many formulations. Based on available toxicological data, it has been classified as toxic for reproduction and as an endocrine disruptor. Despite this, ecotoxicological studies in aquatic wildlife organisms are still scarce. In the present work, the toxic molecular alterations caused by DEHP in aquatic larvae of the midge Chironomus riparius have been studied, by analyzing the transcriptional activity of genes related to some vital cellular pathways, such as the ribosomal machinery (rpL4, rpL13), the cell stress response (hsc70, hsp70, hsp40, hsp27), the ecdysone hormone pathway (EcR), the energy metabolism (GAPDH), and detoxication processes (CYP4G)...
2017: PloS One
https://www.readbyqxmd.com/read/28160993/three-cycles-of-human-biomonitoring-in-flanders-time-trends-observed-in-the-flemish-environment-and-health-study
#20
Greet Schoeters, Eva Govarts, Liesbeth Bruckers, Elly Den Hond, Vera Nelen, Stefaan De Henauw, Isabelle Sioen, Tim S Nawrot, Michelle Plusquin, Annette Vriens, Adrian Covaci, Ilse Loots, Bert Morrens, Dries Coertjens, Nicolas Van Larebeke, Sam De Craemer, Kim Croes, Nathalie Lambrechts, Ann Colles, Willy Baeyens
To follow time trends in exposure to environmental chemicals, three successive campaigns of the Flemish Environment and Health Study (FLEHS) have recruited and sampled in total 5825 participants between 2002 and 2014. Cord samples from newborns, urine and blood samples from 14 to 15 years old adolescents and from adults between 50 and 65 years old were analysed in geographical representative samples of the Flemish population. The data of the different campaigns were considered per age group and per biomarker after adjustment for predefined covariates to take into account differences in characteristics of the study populations over time...
November 18, 2016: International Journal of Hygiene and Environmental Health
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