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https://www.readbyqxmd.com/read/28651165/considering-common-sources-of-exposure-in-association-studies-urinary-benzophenone-3-and-dehp-metabolites-are-associated-with-altered-thyroid-hormone-balance-in-the-nhanes-2007-2008
#1
Sujin Kim, Sunmi Kim, Sungho Won, Kyungho Choi
Epidemiological studies have shown that thyroid hormone balances can be disrupted by chemical exposure. However, many association studies have often failed to consider multiple chemicals with possible common sources of exposure, rendering their conclusions less reliable. In the 2007-2008 National Health and Nutrition Examination Survey (NHANES) from the U.S.A., urinary levels of environmental phenols, parabens, and phthalate metabolites as well as serum thyroid hormones were measured in a general U.S. population (≥12years old, n=1829)...
June 23, 2017: Environment International
https://www.readbyqxmd.com/read/28651148/aldo-keto-reductase-activity-after-diethylhexyl-phthalate-exposure-in-eutopic-and-ectopic-endometrial-cells
#2
La Yeon Kim, Mee Ran Kim, Jang Heub Kim, Hyun Hee Cho
OBJECTIVE: Endometriosis is a multifactorial gynaecological disease in reproductive-age women. Endometriotic tissue is characterized by high prostaglandin levels and progesterone resistance. Human aldo-keto reductases (AKRs) convert progesterone to a less potent metabolite and cause progesterone resistance. Therefore, in this study, we evaluated whether diethylhexyl phthalate (DEHP) alters AKR expression in human ectopic and eutopic endometrium. STUDY DESIGN: We used microarrays and western blotting to study the effects of DEHP, and checked the presence of AKR in endometriosis patients by enzyme-linked immunosorbent assay (ELISA)...
May 22, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28640797/rural-and-urban-differences-in-air-quality-2008-2012-and-community-drinking-water-quality-2010-2015-united-states
#3
Heather Strosnider, Caitlin Kennedy, Michele Monti, Fuyuen Yip
PROBLEM/CONDITION: The places in which persons live, work, and play can contribute to the development of adverse health outcomes. Understanding the differences in risk factors in various environments can help to explain differences in the occurrence of these outcomes and can be used to develop public health programs, interventions, and policies. Efforts to characterize urban and rural differences have largely focused on social and demographic characteristics. A paucity of national standardized environmental data has hindered efforts to characterize differences in the physical aspects of urban and rural areas, such as air and water quality...
June 23, 2017: MMWR. Surveillance Summaries: Morbidity and Mortality Weekly Report. Surveillance Summaries
https://www.readbyqxmd.com/read/28637469/impact-of-phthalate-and-bpa-exposure-during-in-utero-windows-of-susceptibility-on-reproductive-hormones-and-sexual-maturation-in-peripubertal-males
#4
Deborah J Watkins, Brisa N Sánchez, Martha Maria Téllez-Rojo, Joyce M Lee, Adriana Mercado-García, Clara Blank-Goldenberg, Karen E Peterson, John D Meeker
BACKGROUND: Phthalates and BPA are endocrine disrupting chemicals (EDCs) widely used in consumer products. Evidence suggests that phthalate and BPA exposure alters steroid hormone levels in adults, while in utero exposure has been associated with altered fetal reproductive development in boys. However, the impact of exposure during distinct critical windows of in utero development on hormone concentrations and sexual maturation during the pubertal transition has not been examined. The objective of this study was to assess trimester-specific in utero phthalate and BPA exposure in relation to measures of reproductive development among peripubertal boys in a Mexico City birth cohort...
June 21, 2017: Environmental Health: a Global Access Science Source
https://www.readbyqxmd.com/read/28637458/exposure-of-hospitalised-pregnant-women-to-plasticizers-contained-in-medical-devices
#5
Cécile Marie, Sebti Hamlaoui, Lise Bernard, Daniel Bourdeaux, Valérie Sautou, Didier Lémery, Françoise Vendittelli, Marie-Pierre Sauvant-Rochat
BACKGROUND: Medical devices (MDs) in polyvinyl chloride (PVC) are not a well-known source of exposure to plasticizers, in particular during pregnancy. Because of its toxicity, the di-(2-ethylhexyl) phthalate (DEHP) has been replaced by other plasticizers such as di (isononyl)-cyclohexane-1,2-dicarboxilic acid (DINCH), tri-octyltrimellitate (TOTM) and di-(isononyl) phthalate (DiNP). Our study aimed to quantify the plasticizers (DEHP and alternative plasticizers) contained in PVC medical devices used for hospitalised pregnant women and to describe which these MDs had been used (type, number, duration of exposure)...
June 20, 2017: BMC Women's Health
https://www.readbyqxmd.com/read/28634868/occurrence-removal-and-health-risk-assessment-of-phthalate-esters-in-the-process-streams-of-two-different-wastewater-treatment-plants-in-lagos-and-ogun-states-nigeria
#6
O O Olujimi, O A Aroyeun, T F Akinhanmi, T A Arowolo
Phthalate esters (PEs) are one of the environmentally active organic pollutants capable of causing endocrine disruption. The levels of PE congeners were determined in the influent and effluent from Covenant Oxidation Pond (COP) and Ikeja Wastewater Treatment Plant (IWWTP). Standard methods were adopted for determining the physical and chemical parameters of the water samples. The water samples for PE congener's determination were collected, acidified and stored at 4 °C prior to liquid-liquid extraction and analysis by gas chromatograph...
July 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28634325/in-utero-and-lactational-exposure-study-in-rats-to-identify-replacements-for-di-2-ethylhexyl-phthalate
#7
Thomas C Nardelli, Océane Albert, Claudia Lalancette, Martine Culty, Barbara F Hales, Bernard Robaire
Di(2-ethylhexyl) phthalate (DEHP) and other phthalates are ubiquitous environmental contaminants with endocrine disrupting properties. Two novel plasticizers, 1,4 butanediol dibenzoate (BDB) and dioctyl succinate (DOS), have been proposed as potential replacements. Both have desirable properties as plasticizers and minimal in vitro biological effects. Herein, we present an in utero and lactational exposure study comparing DEHP with BDB, DOS, and 1,2-cyclohexane dicarboxylic acid diisononyl ester (DINCH), a commercial alternative...
June 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28618849/mycotoxins-trace-elements-and-phthalates-in-marketed-rice-of-different-origin-and-exposure-assessment
#8
Biljana D Škrbić, Yaqin Ji, Jelena R Živančev, Grigorije G Jovanović, Zhao Jie
The aim of this study was to determine levels of 11 mycotoxins, 10 trace elements and 6 phthalates in rice samples from Serbian and Chinese market. Mycotoxins were not detected in any of the analysed rice samples. Results revealed similar median levels for following elements: Mn, 17.5 and 15.7 mg kg(-1); Fe, 2.47 and 2.12 mg kg(-1); Cu, 1.95 and 1.59 mg kg(-1) in marketed samples from Serbia and China, respectively. Median concentration of Ni in Serbian marketed samples was 1.9 times higher than in Chinese ones...
June 15, 2017: Food Additives & Contaminants. Part B, Surveillance
https://www.readbyqxmd.com/read/28614919/-effects-of-developmental-exposure-to-dehp-on-learning-and-memory-of-mice
#9
D J Wu, B B Luo, Q W Feng, Q N Wang
Objective: To investigate the effects of developmental exposure to DEHP on learning and memory of mice. Methods: Male littermates of ICR mice randomly assigned to five experimental groups (n=14 for each condition) on PND4 to receive distilled water, vehicle and 10, 50 and 200 mg/ (kg·d) DEHP from PND5 to PND38 by gavage, weighing and recording body weight of mice. Open field task were conducted on PND 26 and Morris water maze task were begun from PND30 to PND 37 to evaluate spontaneous exploration activity and emotion, spatial learning and memory performance of pubertal mice, respectively...
April 20, 2017: Chinese Journal of Industrial Hygiene and Occupational Diseases
https://www.readbyqxmd.com/read/28611354/chronic-low-dose-exposure-to-a-mixture-of-environmental-endocrine-disruptors-induces-micrornas-isomirs-deregulation-in-mouse-concomitant-with-intratesticular-estradiol-reduction
#10
Julio Buñay, Eduardo Larriba, Ricardo D Moreno, Jesús Del Mazo
Humans are environmentally exposed not only to single endocrine-disrupting chemicals (EDCs) but to mixtures that affect their reproductive health. In reproductive tissues, microRNAs (miRNAs) are emerging as key targets of EDCs. Here, we analysed changes in the testis "miRNome" (and their biogenesis mechanism) in chronically exposed adult mice to a cocktail of five EDCs containing 0.3 mg/kg-body weight (BW)/day of each phthalate (DEHP, DBP, BBP) and 0.05 mg/kg-BW/day of each alkylphenol (NP, OP), from conception to adulthood...
June 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28609104/di-2-ethylhexyl-phthalate-alters-the-synthesis-and-%C3%AE-oxidation-of-fatty-acids-and-hinders-atp-supply-in-mouse-testes-via-uplc-q-exactive-orbitrap-ms-based-metabonomics-study
#11
Guolin Shen, Lili Zhou, Wei Liu, Yuan Cui, Wenping Xie, Huiming Chen, Wenlian Yu, Wentao Li, Haishan Li
Di(2-ethylhexyl) phthalate (DEHP) is considered to be an environmental endocrine disruptor at high levels of general exposure. Studies show that DEHP may cause testicular toxicity on human being. In this study, metabonomics techniques were used to identify differential endogenous metabolites, draw the network metabolic pathways, and conduct network analysis, to determine the underlying mechanisms of testicular toxicity induced by DEHP. The results showed that DEHP inhibited synthesis and accelerated β-oxidation of fatty acids and impaired the tricarboxylic acid cycle (TCA cycle) and gluconeogenesis, resulting in lactic acid accumulation and an insufficient ATP supply in the microenvironment of the testis...
June 21, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28587233/sex-differences-in-the-association-of-urinary-concentrations-of-phthalates-metabolites-with-self-reported-diabetes-and-cardiovascular-diseases-in-shanghai-adults
#12
Ruihua Dong, Shanzhen Zhao, Han Zhang, Jingsi Chen, Meiru Zhang, Min Wang, Min Wu, Shuguang Li, Bo Chen
Phthalate exposure was reported to be associated with diabetes mellitus (DM) and cardiovascular disease (CVD). Yet, reported associations and the potential sex differences are inconsistent. We conducted a cross-sectional study involving 2330 participants in the Fall of 2012. Urinary metabolites of 10 phthalates were measured. The status of having DM and CVD-related outcomes were self-reported. In the overall study population, the logistic regression analyses showed that the urinary levels of mono-2-ethyl-5-oxohexyphthalate (MEOHP), mono-2-ethyl-5-hydroxyhexylphthalate(MEHHP) and mono-2-ethyl-5-carboxypentylphthalate (MECPP) were positively associated with DM...
June 5, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28579546/mono-2-ethylhexyl-phthalate-induces-autophagy-dependent-apoptosis-through-lysosomal-mitochondrial-axis-in-human-endothelial-cells
#13
Xueyan Wu, Liping Jiang, Xiance Sun, Xiaofeng Yao, Yueran Bai, Xiaofang Liu, Nairong Liu, Xingyue Zhai, Shaopeng Wang, Guang Yang
Mono(2-ethylhexyl) phthalate (MEHP), the active metabolite of di(2-ethylhexyl) phthalate (DEHP), has been known to have adverse effects on the reproductive system, urologic systems, hepatic, developmental toxicities and carcinogenicity. However, the effect of MEHP on cardiovascular toxicity remains unclear. Therefore, we aimed to evaluate the cytotoxic effects of MEHP and the possible molecular mechanism. We found that treatment of EA.hy 926 cells with MEHP induced autophagy at earlier time (6 h) in this study...
June 1, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28576446/prenatal-and-childhood-exposure-to-phthalate-diesters-and-sex-steroid-hormones-in-2-5-8-and-11-year-old-children-a-pilot-study-of-the-taiwan-maternal-and-infant-cohort-study
#14
Hui-Ju Wen, Lillian Sie, Pen-Hua Su, Chia-Jui Chuang, Hsiao-Yen Chen, Chien-Wen Sun, Li-Hua Huang, Chao Agnes Hsiung, Shu-Li Julie Wang
BACKGROUND: Phthalate diesters are commonly used and have been well established as environmental endocrine disruptors. However, few studies have examined their effects on sex steroid hormones in children. We followed children over time to examine the association between pre- and post-natal phthalate exposure and sex steroid hormone levels at 2, 5, 8, and 11 years of age. METHODS: We recruited 430 pregnant women from central Taiwan from 2000 to 2001 and assessed their children at birth, 2, 5, 8, and 11 years of age...
May 30, 2017: Journal of Epidemiology
https://www.readbyqxmd.com/read/28576411/postnatal-hyperoxia-or-dehp-exposure-leads-to-growth-restriction-and-delayed-lung-development-in-newborn-rats
#15
Zhong-Jie Liang, Qiu-Ping Wu, Bei-Tao Chen, Zhen-Lang Lin, Jing Lin, Shang-Qin Chen
BACKGROUND: Di-(2-ethylhexyl) phthalate (DEHP) is commonly used as a plasticizer in many medical devices. We previously showed that maternal DEHP exposure led to restricted growth and delayed lung maturation in newborn rats. As oxygen toxicity continues to be a major risk factor for bronchopulmonary dysplasia, the aim of this study was to examine the effect of hyperoxia, DEHP or DEHP combined with hyperoxia on the growth and lung maturation of newborn rats. METHODS: Newborn rats received DEHP injection, hyperoxia exposure or DEHP injection combined with hyperoxia exposure for one week or two weeks...
May 10, 2017: Pediatrics and Neonatology
https://www.readbyqxmd.com/read/28575823/passive-sampling-for-spatial-and-temporal-monitoring-of-organic-pollutants-in-surface-water-of-a-rural-urban-river-in-kenya
#16
Bilha Saina Chepchirchir, Albrecht Paschke, Gerrit Schüürmann
Passive sampling is an emerging monitoring strategy for surface waters and can be applied in a range of environments including remote locations. Silicone rubber (SR) as a robust single-phase passive sampler was applied to characterize the spatial and temporal variability of organochlorine pesticides (OCPs), polychlorinated biphenyls (PCBs), polyaromatic hydrocarbons (PAHs) and three phthalates, namely, dibutyl phthalate (DBP), benzyl butyl phthalate (BBP) and bis(2-ethylhexyl)phthalate (DEHP) in a tropical river traversing rural and urban catchments...
May 30, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28573083/exposure-marker-discovery-of-phthalates-using-mass-spectrometry
#17
Jen-Yi Hsu, Chia-Lung Shih, Pao-Chi Liao
Phthalates are chemicals widely used in industry and the consequences on human health caused by exposure to these agents are of significant interest currently. The urinary metabolites of phthalates can be measured and used as exposure markers for the assessment of the actual internal contamination of phthalates coming from different sources and absorbed by various ways. The purpose of this paper is to review the markers for exposure and risk assessment of phthalates such as di-methyl phthalate (DMP), di-ethyl phthalate (DEP), di-butyl phthalate (DBP), benzylbutyl phthalate (BBP), di-(2-ethylhexyl)phthalate (DEHP), di-(2-propylheptyl)phthalate (DPHP), di-iso-nonyl phthalate (DINP), di-n-octyl phthalate (DnOP) and di-iso-decyl phthalate (DIDP), and introduction of the analytical approach of three metabolomics data processing approaches that can be used for chemical exposure marker discovery in urine with high-resolution mass spectrometry (HRMS) data...
2017: Mass Spectrometry
https://www.readbyqxmd.com/read/28571686/agonistic-and-antagonistic-effects-of-phthalates-and-their-urinary-metabolites-on-the-steroid-hormone-receptors-er%C3%AE-er%C3%AE-and-ar
#18
Anika Engel, Thorsten Buhrke, Francine Imber, Sönke Jessel, Albrecht Seidel, Wolfgang Völkel, Alfonso Lampen
Phthalate plasticizers have been reported to exert adverse effects via activation of the estrogen receptors ERα and ERβ and inhibition of the androgen receptor AR as molecular initiating events. After oral uptake, phthalates are metabolized to their corresponding monoesters and subsequently to oxidized phthalate monoester derivatives, which are in turn conjugated to glucuronic acid and finally excreted with the urine. In contrast to the parent phthalates, toxicological data regarding their primary and secondary metabolites are rare...
May 29, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/28560624/urinary-metabolomic-profiling-in-rats-exposed-to-dietary-di-2-ethylhexyl-phthalate-dehp-using-ultra-performance-liquid-chromatography-quadrupole-time-of-flight-tandem-mass-spectrometry-uplc-q-tof-ms
#19
Xinwen Dong, Yunbo Zhang, Jin Dong, Yue Zhao, Jipeng Guo, Zhanju Wang, Mingqi Liu, Xiaolin Na, Cheng Wang
Di(2-ethylhexyl) phthalate (DEHP) is an omnipresent environmental chemical with widespread nonoccupational human exposure through multiple ways. Although considerable efforts have been invested to investigate mechanisms of DEHP toxicity, the key metabolic biomarkers of DEHP toxicity remain to be identified. The aim of this study was to assess the urinary metabonomics of dietary DEHP in rats using the technique of ultra-performance liquid chromatography quadrupole time-of-flight tandem mass spectrometry (UPLC/Q-TOF-MS)...
May 30, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28558421/phthalate-metabolites-in-norwegian-mothers-and-children-levels-diurnal-variation-and-use-of-personal-care-products
#20
Amrit Kaur Sakhi, Azemira Sabaredzovic, Enrique Cequier, Cathrine Thomsen
Exposure to phthalates has been associated with reproductive and developmental toxicity. Data on levels of these compounds in the Norwegian population is limited. In this study, urine samples were collected from 48 mothers and their children in two counties in Norway. Eleven different phthalate metabolites originating from six commonly used phthalates in consumer products were determined. Concentrations of phthalate metabolites were significantly higher in children compared to mothers except for mono-ethyl phthalate (MEP)...
December 1, 2017: Science of the Total Environment
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