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https://www.readbyqxmd.com/read/28199414/direct-and-transgenerational-effects-of-low-doses-of-perinatal-di-2-ethylhexyl-phthalate-dehp-on-social-behaviors-in-mice
#1
Kayla M Quinnies, Erin P Harris, Rodney W Snyder, Susan S Sumner, Emilie F Rissman
Di-(2-ethylhexyl) phthalate (DEHP) is an endocrine disrupting chemical commonly used as a plasticizer in medical equipment, food packaging, flooring, and children's toys. DEHP exposure during early development has been associated with adverse neurobehavioral outcomes in children. In animal models, early exposure to DEHP results in abnormal development of the reproductive system as well as altered behavior and neurodevelopment. Based on these data, we hypothesized that developmental exposure to DEHP would decrease social interactions and increase anxiety-like behaviors in mice in a dose-dependent manner, and that the effects would persist over generations...
2017: PloS One
https://www.readbyqxmd.com/read/28192093/the-roles-of-hippocampal-micrornas-in-response-to-acute-postnatal-exposure-to-di-2-ethylhexyl-phthalate-in-female-and-male-rats
#2
Bryan E Luu, Stuart R Green, Christine L Childers, Matthew R Holahan, Kenneth B Storey
Previous studies have shown that di(2-ethylhexyl) phthalate (DEHP) exposure impairs the normal development of pre- and post-synaptic elements of the male, but not female, rat hippocampus. While males seem to be vulnerable to the neurodevelopmental deficits resulting from DEHP exposure, females appear to show a protective response. The purpose of the present study was to characterize hippocampal microRNAs in female and male rats exposed to DEHP to assess whether any patterns emerged that would be consistent with vulnerability in males and resilience in females...
February 9, 2017: Neurotoxicology
https://www.readbyqxmd.com/read/28188053/exposure-of-portuguese-children-to-the-novel-non-phthalate-plasticizer-di-iso-nonyl-cyclohexane-1-2-dicarboxylate-dinch
#3
Luísa Correia-Sá, André Schütze, Sónia Norberto, Conceição Calhau, Valentina F Domingues, Holger M Koch
Di-(iso-nonyl)-cyclohexane-1,2-dicarboxylate (DINCH) is used as substitute for high molecular weight phthalate plasticizers such as di-(2-ethylhexyl) phthalate (DEHP) and di-(iso-nonyl) phthalate (DINP). Due to a rapid substitution process, we must assume omnipresent and increasing DINCH exposures. The aim of this study was to evaluate DINCH exposure in 112 children (4-18years old) from Portugal, divided in two groups: 1) normal-/underweight following the usual diet; and 2) obese/overweight but under strict nutritional guidance...
February 7, 2017: Environment International
https://www.readbyqxmd.com/read/28174045/urinary-concentrations-of-25-phthalate-metabolites-in-brazilian-children-and-their-association-with-oxidative-dna-damage
#4
Bruno A Rocha, Alexandros G Asimakopoulos, Fernando Barbosa, Kurunthachalam Kannan
Exposure of humans to phthalates has received considerable attention due to the ubiquitous occurrence and potential adverse health effects of these chemicals. Nevertheless, little is known about the exposure of the Brazilian population to phthalates. In this study, concentrations of 25 phthalate metabolites were determined in urine samples collected from 300 Brazilian children (6-14years old). Further, the association between urinary phthalate concentrations and a biomarker of oxidative stress, 8-hydroxy-2'-deoxyguanosine (8OHDG), was examined...
February 4, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28174042/phthalate-induced-oxidative-stress-and-association-with-asthma-related-airway-inflammation-in-adolescents
#5
Carmen Franken, Nathalie Lambrechts, Eva Govarts, Gudrun Koppen, Elly Den Hond, Daniëlla Ooms, Stefan Voorspoels, Liesbeth Bruckers, Ilse Loots, Vera Nelen, Isabelle Sioen, Tim S Nawrot, Willy Baeyens, Nicolas Van Larebeke, Greet Schoeters
BACKGROUND: In Belgium, around 8.5% of the children have asthmatic symptoms. Increased asthma risk in children has been reported in relation to exposure to phthalate plasticizers but the underlying mechanisms are largely unknown. AIM: The aim of this study was to identify if oxidative stress, assessed by excision of 8-hydroxydeoxyguanosine (8-OHdG) from damaged DNA, is an intermediate marker for the association between phthalate exposure and doctor-diagnosed asthma...
January 30, 2017: International Journal of Hygiene and Environmental Health
https://www.readbyqxmd.com/read/28171772/maternal-prenatal-urinary-phthalate-metabolite-concentrations-and-visual-recognition-memory-among-infants-at-27-weeks
#6
Khristina N Ipapo, Pam Factor-Litvak, Robin M Whyatt, Antonia M Calafat, Diurka Diaz, Frederica Perera, Virginia Rauh, Julie B Herbstman
BACKGROUND: Prior research has demonstrated inverse associations between maternal prenatal urinary phthalate metabolite concentrations and cognitive development assessed in preschool and school-aged children. While there are a limited number of studies that evaluated these associations during infancy, no study has evaluated whether these associations exist when using the Fagan Test of Infant Intelligence (FTII), which captures novelty preference as a function of visual recognition memory...
February 4, 2017: Environmental Research
https://www.readbyqxmd.com/read/28166271/transcriptional-deregulation-of-genetic-biomarkers-in-chironomus-riparius-larvae-exposed-to-ecologically-relevant-concentrations-of-di-2-ethylhexyl-phthalate-dehp
#7
Óscar Herrero, Gloria Morcillo, Rosario Planelló
Di(2-ethylhexyl) phthalate (DEHP) is a ubiquitous environmental pollutant used worldwide as a plasticizer and solvent in many formulations. Based on available toxicological data, it has been classified as toxic for reproduction and as an endocrine disruptor. Despite this, ecotoxicological studies in aquatic wildlife organisms are still scarce. In the present work, the toxic molecular alterations caused by DEHP in aquatic larvae of the midge Chironomus riparius have been studied, by analyzing the transcriptional activity of genes related to some vital cellular pathways, such as the ribosomal machinery (rpL4, rpL13), the cell stress response (hsc70, hsp70, hsp40, hsp27), the ecdysone hormone pathway (EcR), the energy metabolism (GAPDH), and detoxication processes (CYP4G)...
2017: PloS One
https://www.readbyqxmd.com/read/28160993/three-cycles-of-human-biomonitoring-in-flanders-time-trends-observed-in-the-flemish-environment-and-health-study
#8
Greet Schoeters, Eva Govarts, Liesbeth Bruckers, Elly Den Hond, Vera Nelen, Stefaan De Henauw, Isabelle Sioen, Tim S Nawrot, Michelle Plusquin, Annette Vriens, Adrian Covaci, Ilse Loots, Bert Morrens, Dries Coertjens, Nicolas Van Larebeke, Sam De Craemer, Kim Croes, Nathalie Lambrechts, Ann Colles, Willy Baeyens
To follow time trends in exposure to environmental chemicals, three successive campaigns of the Flemish Environment and Health Study (FLEHS) have recruited and sampled in total 5825 participants between 2002 and 2014. Cord samples from newborns, urine and blood samples from 14 to 15 years old adolescents and from adults between 50 and 65 years old were analysed in geographical representative samples of the Flemish population. The data of the different campaigns were considered per age group and per biomarker after adjustment for predefined covariates to take into account differences in characteristics of the study populations over time...
November 18, 2016: International Journal of Hygiene and Environmental Health
https://www.readbyqxmd.com/read/28153396/associations-between-urinary-phthalate-metabolites-and-bisphenol-a-levels-and-serum-thyroid-hormones-among-the-korean-adult-population-korean-national-environmental-health-survey-konehs-2012-2014
#9
Choonghee Park, Wookhee Choi, Moonyoung Hwang, Youngmee Lee, Suejin Kim, Seungdo Yu, Inae Lee, Domyung Paek, Kyungho Choi
BACKGROUND: Phthalates and bisphenol A (BPA) have been used extensively in many consumer products, resulting in widespread exposure in the general population. Studies have suggested associations between exposure to phthalates and BPA, and serum thyroid hormone levels, but confirmation on larger human populations is warranted. METHODS: Data obtained from nationally representative Korean adults (n=6003) recruited for the second round of the Korean National Environmental Health Survey (KoNEHS), 2012-2014, were employed...
January 30, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28152410/semen-quality-and-insulin-like-factor-3-associations-with-urinary-and-seminal-levels-of-phthalate-metabolites-in-adult-males
#10
Wei-Hsiang Chang, Meng-Hsing Wu, Hsien-An Pan, Pao-Lin Guo, Ching-Chang Lee
Certain phthalates have adverse effects on male reproductive functions in animals, and potentially affect human testicular function and spermatogenesis, but little is known about the active mechanisms. We measured the urinary and seminal phthalate metabolites and explored their associations on insulin-like factor 3 (INSL3) and semen quality. Urine, blood, and semen samples were collected from the male partners of subfertile (n = 253) and fertile (n = 37) couples in a reproductive center in southern Taiwan...
January 16, 2017: Chemosphere
https://www.readbyqxmd.com/read/28146055/effects-of-gender-on-the-association-of-urinary-phthalate-metabolites-with-thyroid-hormones-in-children-a-prospective-cohort-study-in-taiwan
#11
Te-I Weng, Mei-Huei Chen, Guang-Wen Lien, Pai-Shan Chen, Jasper Chia-Cheng Lin, Cheng-Chung Fang, Pau-Chung Chen
Phthalates are considered endocrine disruptors. Our study assessed the gender-specific effects of phthalate exposure on thyroid function in children. In total, 189 Taiwanese children were enrolled in the study. One-spot urine and blood samples were collected for analyzing 12 phthalate metabolites in urine and thyroid hormones. The association between urinary phthalate metabolites and serum thyroid hormones was determined using a generalized linear model with a log link function; the children were categorized into groups for analysis according to the 33rd and 66th percentiles...
January 29, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28140579/adsorption-of-phthalates-on-impervious-indoor-surfaces
#12
Yaoxing Wu, Clara M A Eichler, Weinan Leng, Steven S Cox, Linsey C Marr, John C Little
Sorption of semivolatile organic compounds (SVOCs) onto interior surfaces, often referred to as the "sink effect", and their subsequent re-emission significantly affect the fate and transport of indoor SVOCs and the resulting human exposure. Unfortunately, experimental challenges and the large number of SVOC/surface combinations have impeded progress in understanding sorption of SVOCs on indoor surfaces. An experimental approach based on a diffusion model was thus developed to determine the surface/air partition coefficient K of di-2-ethylhexyl phthalate (DEHP) on typical impervious surfaces including aluminum, steel, glass, and acrylic...
February 13, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28129623/in%C3%A2-vitro-cytotoxic-effects-of-dehp-alternative-plasticizers-and-their-primary-metabolites-on-a-l929%C3%A2-cell-line
#13
Teuta Eljezi, Pierre Pinta, Damien Richard, Jérémy Pinguet, Jean-Michel Chezal, Marie-Christine Chagnon, Valérie Sautou, Gaël Grimandi, Emmanuel Moreau
Phthalic acid esters have been widely used to improve the plasticity of PVC medical devices. They carry a high exposure risk for both humans and the environment in clinical situations. Our study focuses on the cytotoxicity of alternative plasticizers. Postulated primary metabolites were synthesized, not being commercially available. Cytotoxicity assays were performed on L929 murine cells according to the ISO-EN 10993-5 standard design for the biocompatibility of medical devices. The tested concentrations of plasticizers (0...
January 8, 2017: Chemosphere
https://www.readbyqxmd.com/read/28126549/leaching-of-plasticizers-from-polyvinylchloride-perfusion-lines-by-different-lipid-emulsions-for-premature-infants-under-clinical-conditions
#14
David Faessler, Gregor McCombie, Maurus Biedermann, Florian Felder, Ulrike Subotic
Plasticizers migrate from polyvinylchloride (PVC) infusion systems into lipid emulsions. The aim of this study was to investigate the leaching of different plasticizers from PVC perfusion lines by a selection of lipid emulsions under clinical conditions. Seven PVC perfusion lines with an equal length of 150cm and three internal diameters were perfused with three lipid emulsions: Intralipid(®) 20%, ClinOleic(®) 20% and SMOFlipid(®) 20%, mimicking clinical conditions. The concentrations of the plasticizers were measured directly in the emulsions by gas chromatography - mass spectrometry...
January 23, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28123099/teratogenic-effects-of-in-utero-exposure-to-di-2-ethylhexyl-phthalate-dehp-in-b6-129s4-mice
#15
Erica Ungewitter, Emmi Rotgers, Tanika Bantukul, Yasuhiko Kawakami, Grace E Kissling, Humphrey Hung-Chang Yao
Intrauterine exposure to phthalates is known to cause disorders of male reproductive function including androgen insufficiency, decreased fertility, and germ cell defects in rodents. In this study, we set out to investigate the effects of intrauterine exposure to di-(2-ethylhexyl)-phthalate (DEHP) on fetal development of the B6:129S4 mouse strain. Time-mated pregnant C57BL/6 dams were exposed to 0, 5, 250, or 500 mg/kg DEHP with corn oil as the vehicle via oral gavage from embryonic days (E)7 to 16. Survival and gross morphology of the pups were analyzed one day after the last treatment...
January 25, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28116749/alternatives-in-blood-operations-when-choosing-non-dehp-bags
#16
P F van der Meer, D V Devine
The use of di-ethylhexyl-phthalate (DEHP) in blood bags is under discussion due to toxicity concerns and possible restrictions. A questionnaire among 15 blood centres in nine countries showed that none so far have fully switched to non-DEHP blood bags. If centres had to change, sites with a 42-day outdate would choose for a shorter outdating period, while others would allow a higher haemolysis rate (but within current specifications). To improve red cell quality, about half of the centres are willing to move to an alternative red cell storage solution, while the other half would not change for various reasons...
January 24, 2017: Vox Sanguinis
https://www.readbyqxmd.com/read/28115639/combined-effects-of-gestational-phthalate-exposure-and-zinc-deficiency-on-steroid-metabolism-and-growth
#17
J Nuttall, H R Kucera, S Supasai, N W Gaikwad, P I Oteiza
Disruption of steroid hormone signaling has been implicated independently in the developmental abnormalities resulting from maternal phthalate plasticizer exposure and developmental zinc deficiency. This study investigated if secondary zinc deficiency may result from dietary exposure to a low level of DEHP through gestation and if this could be associated with altered steroid metabolism. The interaction between marginal zinc nutrition and DEHP exposure to affect pregnancy outcome, zinc status, and steroid metabolism was also assessed...
January 23, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28115265/in-utero-and-lactational-exposure-to-di-2-ethylhexyl-phthalate-increased-the-susceptibility-of-prostate-carcinogenesis-in-male-offspring
#18
Xiu Wang, Yong Wang, Qi Song, Jianhui Wu, Yan Zhao, Shunheng Yao, Zuyue Sun, Yunhui Zhang
di(2-ethylhexyl) phthalate (DEHP) is one of the most commonly-used plasticizers and can exert estrogen-like effects and anti-androgen-like effects after entering the body. The critical windows for DEHP exposure are in utero and during lactation. There's substantial evidence that hormonally active environmental estrogen perturbations in early life are associated with prostate carcinogenesis susceptibility later in life. In order to explore the effects of in utero and lactational exposure to DEHP on the male offspring's susceptibility to prostate carcinogenesis, we established a rat model of developmental estrogenization: pregnant rats in three treatment groups were treated with DEHP at 0...
January 20, 2017: Reproductive Toxicology
https://www.readbyqxmd.com/read/28115068/the-role-of-oxidative-stress-in-dna-damage-in-pancreatic-%C3%AE-cells-induced-by-di-2-ethylhexyl-phthalate
#19
Yan She, Liping Jiang, Liangliang Zheng, Heming Zuo, Min Chen, Xiance Sun, Qiujuan Li, Chengyan Geng, Guang Yang, Lijie Jiang, Xiaofang Liu
Di(2-ethyhexyl) phthalate (DEHP) is commonly used as a plasticizer, which loosely binds to plastic materials and easily leaches out of these products and enters into the environment. Exposure to DEHP can impair pancreatic beta cells (INS-1 cells)function, which is associated with Insulin Resistance (IR) and type 2 diabetes. However, the mechanism of how DEHP leads to Insulin Resistance is unknown. Our results showed that the cell viability of INS-1 cells exposed to DEHP (0-1600 μM) were decreased in a concentration-dependent manner...
January 20, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28105114/in-utero-exposure-to-di-2-ethylhexyl-phthalate-induces-metabolic-disorder-and-increases-fat-accumulation-in-visceral-depots-of-c57bl-6j-mice-offspring
#20
Hailun Gu, Yali Liu, Wei Wang, Lifeng Ding, Weiping Teng, Li Liu
Excessive visceral fat accumulation is associated with metabolic disorders. Di-(2-ethylhexyl) phthalate (DEHP), a candidate environmental obesogen, affects lipid metabolism and adipogenesis. Perinatal exposure to DEHP may be associated with metabolic disorders of dams and offspring. The aim of the present study was to explore the effects of exposure of pregnant dams to DEHP on the metabolism and fat distribution of their offspring, and to determine the mechanisms for these effects. Pregnant C57BL/6J mice were administered DEHP via gavage (0...
December 2016: Experimental and Therapeutic Medicine
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