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https://www.readbyqxmd.com/read/28211816/levodopa-carbidopa-intestinal-gel-pharmacokinetics-lower-variability-than-oral-levodopa-carbidopa
#1
Ahmed A Othman, Matthew Rosebraugh, Krai Chatamra, Charles Locke, Sandeep Dutta
In a double-blind, double-dummy, double-titration Phase 3 trial in advanced Parkinson's disease (PD) patients, the efficacy and safety of Levodopa-carbidopa intestinal gel (LCIG) infusion were characterized relative to immediate-release oral levodopa-carbidopa (LC-oral) treatment. We present in this report the comparative pharmacokinetic profiles of LCIG and LC-oral from this pivotal study. The results presented in this report clearly demonstrate that LCIG results in lower variability and fluctuations in levodopa and carbidopa plasma concentrations compared to LC-oral...
February 16, 2017: Journal of Parkinson's Disease
https://www.readbyqxmd.com/read/28203475/benefit-from-the-chin-down-maneuver-in-the-swallowing-performance-and-self-perception-of-parkinson-s-disease-patients
#2
Annelise Ayres, Geraldo Pereira Jotz, Carlos R M Rieder, Maira Rozenfeld Olchik
Aims. To verify the effectiveness of the maneuver application in swallowing therapy with PD. Materials and Method. We performed an open-label trial, with three groups compounds by PD individuals: the experimental group, control group, and orientation group. The study included PD patients with dysphagia. A cognitive screening, through a questionnaire about depression and quality of life, was conducted. Swallowing assessment was performed through (1) fiberoptic endoscopic evaluation of swallowing (FEES); (2) clinical evaluation and Functional Oral Intake Scale (FOIS); and (3) assessment of the quality life related to swallowing (SWALQOL)...
2017: Parkinson's Disease
https://www.readbyqxmd.com/read/28202824/-disease-modifying-therapy-for-parkinson-s-disease
#3
Hideki Shimura, Nobutaka Hattori
Currently, treatment of Parkinson's disease aims at alleviating its symptoms. However development of disease-modifying drugs has been a remarkable advancement in recent years. Furthermore, clinical trials of immunotherapy against α-synuclein, a protein involved in the pathogenesis of and lesion expansion in Parkinson's disease, have been initiated. Here, the disease-modifying treatment for patients with Parkinson's disease including the current α-synuclein immunotherapy, gene therapy, protein injection therapy, and cell transplantation therapy, has been reviewed...
February 2017: Brain and Nerve, Shinkei Kenkyū No Shinpo
https://www.readbyqxmd.com/read/28195407/a-pilot-trial-of-square-biphasic-pulse-deep-brain-stimulation-for-dystonia-the-bip-dystonia-study
#4
Leonardo Almeida, Daniel Martinez-Ramirez, Bilal Ahmed, Wissam Deeb, Sol De Jesus, Jared Skinner, Matthew J Terza, Umer Akbar, Robert S Raike, Chris J Hass, Michael S Okun
BACKGROUND: Dystonia often has inconsistent benefits and requires more energy-demanding DBS settings. Studies suggest that squared biphasic pulses could provide significant clinical benefit; however, dystonia patients have not been explored. OBJECTIVES: To assess safety and tolerability of square biphasic DBS in dystonia patients. METHODS: This study included primary generalized or cervical dystonia patients with bilateral GPi DBS. Square biphasic pulses were implemented and patients were assessed at baseline, immediately postwashout, post-30-minute washout, 1 hour post- and 2 hours postinitiation of investigational settings...
February 13, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28190675/effectiveness-of-exergaming-in-improving-functional-balance-fatigue-and-quality-of-life-in-parkinson-s-disease-a-pilot-randomized-controlled-trial
#5
REVIEW
Camila Gemin Ribas, Letícia Alves da Silva, Marina Ribas Corrêa, Hélio Ghizone Teive, Silvia Valderramas
: Although motor symptoms in Parkinson's disease (PD) are well established, few studies have described the effects of exergaming on the clinical and functional outcomes of PD. OBJECTIVES: To analyze the effectiveness of exergaming in improving functional balance, fatigue, functional exercise capacity and quality of life in PD. METHODS: The study population consisted of 20 patients (12 males and 8 females) aged 61 ± 9.11 years allocated into two groups: an exergaming group (EGG) (n = 10) and a conventional exercise, or control, group (CG) (n = 10)...
February 7, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28188080/the-effect-of-18f-fdg-pet-image-reconstruction-algorithms-on-the-expression-of-characteristic-metabolic-brain-network-in-parkinson-s-disease
#6
Petra Tomše, Luka Jensterle, Sebastijan Rep, Marko Grmek, Katja Zaletel, David Eidelberg, Vijay Dhawan, Yilong Ma, Maja Trošt
PURPOSE: To evaluate the reproducibility of the expression of Parkinson's Disease Related Pattern (PDRP) across multiple sets of 18F-FDG-PET brain images reconstructed with different reconstruction algorithms. METHODS: 18F-FDG-PET brain imaging was performed in two independent cohorts of Parkinson's disease (PD) patients and normal controls (NC). Slovenian cohort (20 PD patients, 20 NC) was scanned with Siemens Biograph mCT camera and reconstructed using FBP, FBP+TOF, OSEM, OSEM+TOF, OSEM+PSF and OSEM+PSF+TOF...
February 7, 2017: Physica Medica: PM
https://www.readbyqxmd.com/read/28180961/dermal-phospho-alpha-synuclein-deposits-confirm-rem-sleep-behaviour-disorder-as-prodromal-parkinson-s-disease
#7
Kathrin Doppler, Hanna-Maria Jentschke, Lena Schulmeyer, David Vadasz, Annette Janzen, Markus Luster, Helmut Höffken, Geert Mayer, Joachim Brumberg, Jan Booij, Thomas Musacchio, Stephan Klebe, Elisabeth Sittig-Wiegand, Jens Volkmann, Claudia Sommer, Wolfgang H Oertel
Phosphorylated alpha-synuclein (p-alpha-syn) deposits, one of the neuropathological hallmarks of Parkinson's disease (PD), have recently been detected in dermal nerve fibres in PD patients with good specificity and sensitivity. Here, we studied whether p-alpha-syn may serve as a biomarker in patients with a high risk of developing PD, such as those with REM sleep behaviour disorder (RBD). We compared the presence and distribution of p-alpha-syn deposits in dermal nerve fibres in 18 patients with RBD, 25 patients with early PD and 20 normal controls...
February 8, 2017: Acta Neuropathologica
https://www.readbyqxmd.com/read/28178876/designing-fecal-microbiota-transplant-trials-that-account-for-differences-in-donor-stool-efficacy
#8
Scott W Olesen, Thomas Gurry, Eric J Alm
Fecal microbiota transplantation is a highly effective intervention for patients suffering from recurrent Clostridium difficile, a common hospital-acquired infection. Fecal microbiota transplantation's success as a therapy for C. difficile has inspired interest in performing clinical trials that experiment with fecal microbiota transplantation as a therapy for other conditions like inflammatory bowel disease, obesity, diabetes, and Parkinson's disease. Results from clinical trials that use fecal microbiota transplantation to treat inflammatory bowel disease suggest that, for at least one condition beyond C...
January 1, 2017: Statistical Methods in Medical Research
https://www.readbyqxmd.com/read/28176547/improving-prospective-memory-in-persons-with-parkinson-disease
#9
Erin R Foster, Mark A McDaniel, Peter G Rendell
BACKGROUND: Prospective memory (PM) is essential for productive and independent living and necessary for compliance with prescribed health behaviors. Parkinson disease (PD) can cause PM deficits that are associated with activity limitations and reduced quality of life. Forming implementation intentions (IIs) is an encoding strategy that may improve PM in this population. OBJECTIVE: To determine the effect of IIs on PM performance in PD. METHODS: This was a laboratory-based randomized controlled trial...
February 1, 2017: Neurorehabilitation and Neural Repair
https://www.readbyqxmd.com/read/28175402/132%C3%A2-a-randomized-sham-controlled-trial-of-transcranial-magnetic-resonance-guided-focused-ultrasound-thalamotomy-trial-for-the-treatment-of-tremor-dominant-idiopathic-parkinson-disease
#10
Aaron E Bond, Robert Dallapiazza, Diane Huss, Amy L Warren, Scott Sperling, Ryder Gwinn, Binit B Shah, W Jeffrey Elias
No abstract text is available yet for this article.
August 1, 2016: Neurosurgery
https://www.readbyqxmd.com/read/28175388/134%C3%A2-vantage-trial-three-year-outcomes-of-a-prospective-multicenter-trial-evaluating-deep-brain-stimulation-with-a-new-multiple-source-constant-current-rechargeable-system-in-parkinson-disease
#11
Lars Timmermann, Roshini Jain, Lilly Chen, Thomas Brucke, Fernando Seijo, Esther Suarez San Martin, Claire Haegelen, Marc Verin, Veerle Visser-Vandewalle, Michael T Barbe, Steven Gill, Alan Whone, Mauro Porta, Domenico Servello, Francois Alesch
No abstract text is available yet for this article.
August 1, 2016: Neurosurgery
https://www.readbyqxmd.com/read/28173775/evaluation-and-implementation-of-highly-challenging-balance-training-in-clinical-practice-for-people-with-parkinson-s-disease-protocol-for-the-hibalance-effectiveness-implementation-trial
#12
Breiffni Leavy, Lydia Kwak, Maria Hagströmer, Erika Franzén
BACKGROUND: If people with progressive neurological diseases are to avail of evidence-based rehabilitation, programs found effective in randomized controlled trials (RCT's) must firstly be adapted and tested in clinical effectiveness studies as a means of strengthening their evidence base. This paper describes the protocol for an effectiveness-implementation trial that will assess the clinical effectiveness of a highly challenging balance training program (the HiBalance program) for people with mild-moderate Parkinson's disease (PD) while simultaneously collecting data concerning the way in which the program is implemented...
February 7, 2017: BMC Neurology
https://www.readbyqxmd.com/read/28167197/influence-of-treadmill-gait-training-with-additional-load-on-motor-function-postural-instability-and-history-of-falls-for-individuals-with-parkinson-s-disease-a-randomized-clinical-trial
#13
Larissa Coutinho de Lucena Trigueiro, Gabriela Lopes Gama, Tatiana Souza Ribeiro, Louise Gabriella Lopes de Macedo Ferreira, Élida Rayanne Viana Pinheiro Galvão, Emília Márcia Gomes de Souza E Silva, Clécio de Oliveira Godeiro Júnior, Ana Raquel Rodrigues Lindquist
BACKGROUND: Evaluate the effects of additional load (5% and 10% of body weight) with treadmill gait training on the motor aspects in Parkinson's disease (PD). METHODS: Randomized controlled single-blind trial with 30 individuals with PD. The volunteers were divided into three groups (treadmill with 0%, 5% or 10% load), where Unified Parkinson's Disease Rating Scale was applied. Treadmill gait training was conducted over 4 consecutive weeks, with three weekly sessions of 30 min each...
January 2017: Journal of Bodywork and Movement Therapies
https://www.readbyqxmd.com/read/28166239/depletion-of-aadc-activity-in-caudate-nucleus-and-putamen-of-parkinson-s-disease-patients-implications-for-ongoing-aav2-aadc-gene-therapy-trial
#14
Agnieszka Ciesielska, Lluis Samaranch, Waldy San Sebastian, Dennis W Dickson, Samuel Goldman, John Forsayeth, Krystof S Bankiewicz
In Parkinson's disease (PD), aromatic L-amino acid decarboxylase (AADC) is the rate-limiting enzyme in the conversion of L-DOPA (Sinemet) to dopamine (DA). Previous studies in PD animal models demonstrated that lesion of dopaminergic neurons is associated with profound loss of AADC activity in the striatum, blocking efficient conversion of L-DOPA to DA. Relatively few studies have directly analyzed AADC in PD brains. Thus, the aim of this study was to gain a better understanding of regional changes in AADC activity, DA, serotonin and their monoamine metabolites in the striatum of PD patients and experimentally lesioned animals (rat and MPTP-treated nonhuman primate, NHP)...
2017: PloS One
https://www.readbyqxmd.com/read/28160153/differential-behavioral-outcomes-following-neonatal-versus-fetal-human-retinal-pigment-epithelial-cell-striatal-implants-in-parkinsonian-rats
#15
Kaspar Russ, Joseph Flores, Tomasz Brudek, Doris J Doudet
Following the failure of a Phase II clinical study evaluating human retinal pigment epithelial (hRPE) cell implants as a potential treatment option for Parkinson's disease, speculation has centered on implant function and survival as possible contributors to the therapeutic outcomes. We recently reported that neonatal hRPE cells, similar to hRPE cells used in the Phase II clinical study, produced short-lived in vitro and limited in vivo trophic factors, which supports that assumption. We hypothesize that the switch from fetal to neonatal hRPE cells, between the Phase I and the Phase II clinical trial may be partly responsible for the later negative outcomes...
February 4, 2017: Journal of Neural Transmission
https://www.readbyqxmd.com/read/28158197/rehabilitation-in-progressive-supranuclear-palsy-effectiveness-of-two-multidisciplinary-treatments
#16
Ilaria Clerici, Davide Ferrazzoli, Roberto Maestri, Fabiola Bossio, Ilaria Zivi, Margherita Canesi, Gianni Pezzoli, Giuseppe Frazzitta
BACKGROUND: to date, there are no medical or surgical treatments for progressive supranuclear palsy (PSP). It is possible to speculate that patients with PSP could benefit from rehabilitative treatments designed for Parkinson's disease, including the use of robot-assisted walking training. OBJECTIVE: to evaluate whether the use of the robotic device Lokomat® is superior in PSP patients to the use of treadmill with visual cues and auditory feedbacks (treadmill-plus) in the context of an aerobic, multidisciplinary, intensive, motor-cognitive and goal-based rehabilitation treatment (MIRT) conceived for Parkinsonian patients...
2017: PloS One
https://www.readbyqxmd.com/read/28157097/combination-therapy-with-zonisamide-and-antiparkinson-drugs-for-parkinson-s-disease-a-meta-analysis
#17
Shinji Matsunaga, Taro Kishi, Nakao Iwata
BACKGROUND: There is uncertainty about the efficacy and tolerability of zonisamide for Parkinson's disease (PD). OBJECTIVE: We performed a meta-analysis of zonisamide treatment in PD patients who received antiparkinson drugs such as levodopa. METHODS: The primary outcome measures were the Unified Parkinson's Disease Rating Scale (UPDRS) Part III scores, wearing-off time, and discontinuation rate due to all causes. Secondary outcome measures were UPDRS total and subscale scores; discontinuation rates due to adverse events, inefficacy, and death; and individual adverse events...
February 1, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28151878/a-training-approach-to-improve-stepping-automaticity-while-dual-tasking-in-parkinson-s-disease-a-prospective-pilot-study
#18
Taylor Chomiak, Alexander Watts, Nicole Meyer, Fernando V Pereira, Bin Hu
BACKGROUND: Deficits in motor movement automaticity in Parkinson's disease (PD), especially during multitasking, are early and consistent hallmarks of cognitive function decline, which increases fall risk and reduces quality of life. This study aimed to test the feasibility and potential efficacy of a wearable sensor-enabled technological platform designed for an in-home music-contingent stepping-in-place (SIP) training program to improve step automaticity during dual-tasking (DT). METHODS: This was a 4-week prospective intervention pilot study...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28139169/validation-of-a-behavioral-approach-for-measuring-saccades-in-parkinson-s-disease
#19
Travis H Turner, Jenna B Renfroe, Amy Duppstadt-Delambo, Vanessa K Hinson
Speed and control of saccades are related to disease progression and cognitive functioning in Parkinson's disease (PD). Traditional eye-tracking complexities encumber application for individual evaluations and clinical trials. The authors examined psychometric properties of standalone tasks for reflexive prosaccade latency, volitional saccade initiation, and saccade inhibition (antisaccade) in a heterogeneous sample of 65 PD patients. Demographics had minimal impact on task performance. Thirty-day test-retest reliability estimates for behavioral tasks were acceptable and similar to traditional eye tracking...
January 31, 2017: Journal of Motor Behavior
https://www.readbyqxmd.com/read/28134783/attitudes-and-learning-through-practice-are-key-to-delivering-brief-interventions-for-heavy-drinking-in-primary-health-care-analyses-from-the-odhin-five-country-cluster-randomized-factorial-trial
#20
Peter Anderson, Eileen Kaner, Myrna Keurhorst, Preben Bendtsen, Ben van Steenkiste, Jillian Reynolds, Lidia Segura, Marcin Wojnar, Karolina Kłoda, Kathryn Parkinson, Colin Drummond, Katarzyna Okulicz-Kozaryn, Artur Mierzecki, Miranda Laurant, Dorothy Newbury-Birch, Antoni Gual
In this paper, we test path models that study the interrelations between primary health care provider attitudes towards working with drinkers, their screening and brief advice activity, and their receipt of training and support and financial reimbursement. Study participants were 756 primary health care providers from 120 primary health care units (PHCUs) in different locations throughout Catalonia, England, The Netherlands, Poland, and Sweden. Our interventions were training and support and financial reimbursement to providers...
January 26, 2017: International Journal of Environmental Research and Public Health
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