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https://www.readbyqxmd.com/read/28720881/patients-with-orthostatic-intolerance-relationship-to-autonomic-function-tests-results-and-reproducibility-of-symptoms-on-tilt
#1
Hyung Lee, Phillip A Low, Hyun Ah Kim
This study was designed to investigate the frequency and pattern of orthostatic symptoms during head-up tilt (HUT) in patients with orthostatic intolerance during daily life, and to identify the relationship between the orthostatic symptoms during HUT and autonomic parameters. We prospectively collected autonomic data from 464 patients with orthostatic symptoms. Adrenergic and cardiovagal function tests including HUT were performed. Based on HUT results, we divided patients into orthostatic hypotension (OH), postural tachycardia syndrome (POTS), or normal HUT groups...
July 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28717991/prolonged-bed-rest-impairs-rapid-cpi-17-phosphorylation-and-contraction-in-rat-mesenteric-resistance-arteries-to-cause-orthostatic-hypotension
#2
Toshio Kitazawa, Kazuyo Kitazawa
Prolonged bed rest (PBR) causes orthostatic hypotension (OH). Rapid constriction of splanchnic resistance arteries in response to a sudden increase in sympathetic tone contributes to the recovery of orthostatic arterial pressure upon standing. However, the molecular mechanism of PBR-induced dysfunction in arterial constriction is not fully understood. Previously, we showed that CPI-17, a regulatory protein for myosin phosphatase, mediates α1A-adrenergic receptor-induced rapid contraction of small mesenteric arteries...
July 17, 2017: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/28717053/pure-autonomic-failure
#3
REVIEW
Thomas P Brown
Pure autonomic failure is a degenerative disorder of the peripheral autonomic nervous system. Patients experience symptomatic hypotension that requires them to sit, squat or lie down to prevent syncope. It is associated with characteristic histopathological findings, resulting in neuronal cytoplasmic inclusions in the peripheral autonomic nerves. These lesions are responsible for defects in the synthesis and release of norepinephrine from sympathetic nerve terminals, resulting in significant hypotension. Patients with autonomic failure also have exaggerated blood pressure responses to common stimuli such as food or fluid intake, heat, exercise and medications...
July 17, 2017: Practical Neurology
https://www.readbyqxmd.com/read/28714763/effects-of-trial-duration-on-intrasession-reliability-of-single-leg-balance-testing-on-stable-and-unstable-surfaces
#4
Bryan I Riemann, Kelsey Piersol, George J Davies
CONTEXT: Single leg balance testing is a commonly used tool in sports medicine; however, there has been no consensus on trial duration needed to obtain reliable measures. OBJECTIVE: This investigation sought to determine the minimum trial duration required to obtain the highest intrasession single and average trial reliability for single leg balance testing on stable and unstable surfaces using dominant and nondominant limbs. DESIGN: Intrasession reliability...
July 17, 2017: Journal of Sport Rehabilitation
https://www.readbyqxmd.com/read/28713055/anterior-and-nasal-transposition-of-inferior-oblique-muscle-in-cases-of-superior-oblique-palsy
#5
Rohit Saxena, Medha Sharma, Digvijay Singh, Pradeep Sharma
PURPOSE: To report long-term outcome of inferior oblique anterior and nasal transposition in superior oblique palsy. METHODS: The medical records of patients with superior oblique palsy who underwent inferior oblique anterior nasal transposition were reviewed retrospectively. A comprehensive ophthalmic evaluation, including prism bar cover test and measurement of torsion, was performed for all cases. One-year postoperative results were evaluated for alignment in primary gaze, contralateral gaze, and upgaze; reduction in inferior oblique overaction and changes in fundus torsion to assess long-term outcome of the procedure...
July 13, 2017: Journal of AAPOS: the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
https://www.readbyqxmd.com/read/28712801/the-effect-of-pelvic-tilt-and-femoral-head-size-on-hip-range-of-motion-to-impingement
#6
Thomas F McCarthy, Jim Nevelos, Randa K Elmallah, Morad Chughtai, Anton Khlopas, Vincent Alipit, Timothy C Wagner, Michael A Mont
BACKGROUND: About 50%-70% of dislocators have cups placed within so-called "safe zones." It has been postulated that factors such as femoral head size and pelvic tilt, obliquity, or rotation may influence postoperative stability. Therefore, we assessed varying degrees of pelvic tilt and head sizes on the range of motion (ROM) to impingement. METHODS: A hip simulator was used to import models of 10 subjects who performed object pickup, squatting, and low-chair rising...
June 15, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28710358/latitudinal-cline-of-chronotype
#7
Mario André Leocadio-Miguel, Fernando Mazzili Louzada, Leandro Lourenção Duarte, Roberta Peixoto Areas, Marilene Alam, Marcelo Ventura Freire, John Fontenele-Araujo, Luiz Menna-Barreto, Mario Pedrazzoli
The rotation of the Earth around its own axis and around the sun determines the characteristics of the light/dark cycle, the most stable and ancient 24 h temporal cue for all organisms. Due to the tilt in the earth's axis in relation to the plane of the earth's orbit around the sun, sunlight reaches the Earth differentially depending on the latitude. The timing of circadian rhythms varies among individuals of a given population and biological and environmental factors underlie this variability. In the present study, we tested the hypothesis that latitude is associated to the regulation of circadian rhythm in humans...
July 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28699211/better-and-faster-velocity-pulsatility-assessment-in-cerebral-white-matter-perforating-arteries-with-7t-quantitative-flow-mri-through-improved-slice-profile-acquisition-scheme-and-postprocessing
#8
Lennart Geurts, Geert Jan Biessels, Peter Luijten, Jaco Zwanenburg
PURPOSE: A previously published cardiac-gated 2D Qflow protocol at 7 T in cerebral perforating arteries was optimized to reduce velocity underestimation and improve temporal resolution. METHODS: First, the signal-to-noise ratio (SNR) gain of the velocity measurement (SNRv ) was tested for two signal averages versus one. Second, the decrease in velocity underestimation with a tilted optimized nonsaturating excitation (TONE) pulse was tested. Third, the decrease in pulsatility index (PI) underestimation through improved temporal resolution was tested...
July 11, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28698944/petra-msvat-space-and-semac-sequences-for-metal-artefact-reduction-in-dental-mr-imaging
#9
Tim Hilgenfeld, Marcel Prager, Alexander Heil, Franz Sebastian Schwindling, Mathias Nittka, David Grodzki, Peter Rammelsberg, Martin Bendszus, Sabine Heiland
OBJECTIVES: Dental MRI is often impaired by artefacts due to metallic dental materials. Several sequences were developed to reduce susceptibility artefacts. Here, we evaluated a set of sequences for artefact reduction for dental MRI for the first time. METHODS: Artefact volume, signal-to-noise ratio (SNR) and image quality were assessed on a 3-T MRI for pointwise encoding time reduction with radial acquisition (PETRA), multiple-slab acquisition with view angle tilting gradient, based on a sampling perfection with application-optimised contrasts using different flip angle evolution (SPACE) sequence (MSVAT-SPACE), slice-encoding for metal-artefact correction (SEMAC) and compared to a standard SPACE and a standard turbo-spin-echo (TSE) sequence...
July 11, 2017: European Radiology
https://www.readbyqxmd.com/read/28694216/an-analysis-of-radiographic-parameters-comparison-between-lumbar-spine-latericumbent-and-full-length-lateral-standing-radiographs
#10
Zhiwei Yang, Fang Xie, Jianxin Zhang, Zhuowen Liang, Zhe Wang, Xueyu Hu, Zhuojing Luo
BACKGROUND CONTEXT: The lumbar spine latericumbent and full-length lateral standing radiographs are most commonly used to assess lumbar disorder. However, there are few literatures regarding the difference and correlation of the sagittal parameters between the two shooting positions. PURPOSE: To investigate the difference of sagittal parameters in spine lateral radiographs between latericumbent and upright positions, identify the correlation and establish a preliminary linear fitting formula...
July 7, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28684212/validation-of-a-new-2-d-technique-for-radiographic-wear-measurement-of-cemented-highly-cross-linked-polyethylene-acetabular-cups
#11
Brian Derbyshire, Bilal Barkatali
A new 2-D radiographic wear measurement system has been developed which enables the low wear of highly cross-linked polyethylene acetabular cups to be accurately and precisely measured from standard, pelvis radiographs. The software was validated using radiographic images of a measurement jig which could vary the cup orientation and simulate the effect of pelvic tilt/rotation. Wear was simulated using accurately measured plastic shims to vary the position of the femoral head relative to the cup. The effects of varying "wear" penetration, "wear" direction, cup orientation and X-ray focus position were assessed...
July 3, 2017: Medical Engineering & Physics
https://www.readbyqxmd.com/read/28681708/influence-of-autonomic-nervous-system-dysfunction-in-the-genesis-of-sleep-disorders-in-fibromyalgia-patients
#12
Maurizio Rizzi, Dejan Radovanovic, Pierachille Santus, Andrea Airoldi, Francesca Frassanito, Silvia Vanni, Andrea Cristiano, Ignazio Francesco Masala, Piercarlo Sarzi-Puttini
OBJECTIVES: Fibromyalgia (FM) is characterised by chronic musculoskeletal pain, autonomic nervous system (ANS) dysfunction, and disturbed sleep. The aim of this study was to evaluate the influence of ANS dysfunction on the genesis of sleep disorders. METHODS: Fifty female FM patients and 45 healthy subjects matched for age, gender and body mass index underwent a clinical, polysomnographic and autonomic profile evaluation at rest and during a tilt test in order to determine muscle sympathetic nerve activity (MSNA), plasma catecholamine levels, and the spectral indices of cardiac sympathetic (LFRR) and vagal (HFRR) modulation computed by means of the spectrum analysis of RR during sleep...
May 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28681408/role-of-peripheral-vascular-resistance-as-an-indicator-of-cardiovascular-abnormalities-in-patients-with-parkinson-s-disease
#13
Monika Zawadka-Kunikowska, Joanna Słomko, Małgorzata Tafil-Klawe, Jacek J Klawe, Agnieszka Cudnoch-Jędrzejewska, Julia L Newton, Paweł Zalewski
The aim of this study was to evaluate cardiovascular autonomic modulation in response to an orthostatic stress in healthy subjects and Parkinson's disease (PD). The study included 47 controls and 56 PD patients divided into groups (vasoconstrictor PD, vasodilator PD, control) according to vasodilation/vasoconstriction response during 70° head up tilt test. Using Impedance cardiography (ICG) and electrocardiography (ECG) we measured stroke volume, cardiac output, left ventricular work index, left ventricular ejection time, acceleration index, index of contractility, Heather index, thoracic fluid content, total peripheral resistance, total arterial compliance...
July 5, 2017: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/28681121/indexes-of-cerebral-autoregulation-do-not-reflect-impairment-in-syncope-insights-from-head-up-tilt-test-of-vasovagal-and-autonomic-failure-subjects
#14
Pedro Castro, João Freitas, Rosa Santos, Ronney Panerai, Elsa Azevedo
PURPOSE: The study of dynamic cerebral autoregulation (CA), which adapts cerebral blood flow to arterial blood pressure (ABP) fluctuations, has been limited in orthostatic intolerance syndromes, mainly due to its stationary prerequisites hardly to meet during maneuvers to provoke syncope itself. New techniques of continuous estimates of CA could overcome this pitfall. We aimed to evaluate CA during head-up tilt test in common conditions causing syncope. METHODS: We compared three groups: eight controls; eight patients with autonomic failure due to familial amyloidotic polyneuropathy; eight patients with vasovagal syncope (VVS)...
July 5, 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/28681088/mediolateral-femoral-component-position-in-tka-significantly-alters-patella-shift-and-femoral-roll-back
#15
Arnd Steinbrück, Christian Schröder, Matthias Woiczinski, Florian Schmidutz, Peter E Müller, Volkmar Jansson, Andreas Fottner
PURPOSE: Increased retropatellar pressure and altered kinematics are associated with anterior knee pain and unsatisfied patients after total knee arthroplasty (TKA). Since malposition of the implant is believed to contribute to postoperative pain, we performed this in vitro study to evaluate the influence of mediolateral femoral component position on retropatellar pressure as well as tibio-femoral and patella kinematics. METHODS: For the test, a fixed-bearing TKA was implanted in eight fresh frozen cadaver specimens...
July 5, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28674628/syndromes-of-orthostatic-intolerance-and-syncope-in-young-adults
#16
Viktor Hamrefors, Jasmina Medic Spahic, David Nilsson, Martin Senneby, Richard Sutton, Olle Melander, Artur Fedorowski
OBJECTIVE: To explore the clinical and neuroendocrine characteristics of syndromes of orthostatic intolerance and syncope in young adults. METHODS: Two hundred and thirty-six patients aged 18-40 years with orthostatic intolerance and/or syncope were examined by head-up tilt test (HUT). Plasma levels of epinephrine, norepinephrine, renin, C-terminal-pro-arginine-vasopressin (CT-proAVP), C-terminal-endothelin-1 and mid-regional-fragment of pro-atrial-natriuretic-peptide (MR-proANP) were analysed...
2017: Open Heart
https://www.readbyqxmd.com/read/28669087/typical-vasovagal-syncope-as-a-defense-mechanism-for-the-heart-by-contrasting-sympathetic-overactivity
#17
REVIEW
Paolo Alboni, Marco Alboni
Many observations suggest that typical (emotional or orthostatic) vasovagal syncope (VVS) is not a disease, but rather a manifestation of a non-pathological trait. Some authors have hypothesized this type of syncope as a "defense mechanism" for the organism and a few theories have been postulated. Under the human violent conflicts theory, the VVS evolved during the Paleolithic era only in the human lineage. In this evolutionary period, a predominant cause of death was wounding by a sharp object. This theory could explain the occurrence of emotional VVS, but not of the orthostatic one...
July 1, 2017: Clinical Autonomic Research: Official Journal of the Clinical Autonomic Research Society
https://www.readbyqxmd.com/read/28667956/first-demonstration-of-simultaneous-measurement-of-beam-current-beam-position-and-beam-tilt-on-induction-linac-using-combined-b-dot-monitor
#18
Xiaozhong He, Jian Pang, Nan Chen, Qin Li, Wenhua Dai, Chaofan Ma, Liangchao Zhao, Feng Gao, Zhiyong Dai
The authors previously reported that the axial B-dots can be used to directly measure the beam tilt and demonstrated that the axial B-dots are applicable to a coaxial calibration stand. In this study, a combined B-dot monitor composed of four axial B-dot loops and four azimuthal ones is tested for the simultaneous measurement of the time-varying beam current, beam offset, and beam tilt at the output of the injector of the DRAGON-I induction linac. In the experiments, the beam offset and beam tilt at the position of the monitor are proportionally adjusted using a pair of steering coils...
June 2017: Review of Scientific Instruments
https://www.readbyqxmd.com/read/28662692/comparison-of-fixed-and-mobile-bearing-total-knee-arthroplasty-in-terms-of-patellofemoral-pain-and-function-a-prospective-randomised-controlled-trial
#19
P Z Feczko, L M Jutten, M J van Steyn, P Deckers, P J Emans, J J Arts
BACKGROUND: Despite growing evidence in the literature, there is still a lack of consensus regarding the use of the mobile-bearing (MB) design total knee arthroplasty (TKA). METHODS: In a prospective, comparative, randomised, single centre trial, 106 patients with end-stage osteoarthritis of the knee were randomised to either an MB or fixed-bearing (FB) group to receive posterior stabilised (PS)-TKA using a standard medial parapatellar approach and patellar resurfacing with follow-up (FU) for 5 years...
June 29, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28662088/automated-interpretation-of-influenza-hemagglutination-inhibition-hai-assays-is-plate-tilting-necessary
#20
Garrett Wilson, Zhiping Ye, Hang Xie, Steven Vahl, Erica Dawson, Kathy Rowlen
The hemagglutination inhibition assay (HAI) is widely used to evaluate vaccine-induced antibody responses as well as to antigenically characterize influenza viruses. The results of an HAI assay are based on an endpoint titration where the titers are generally manually interpreted and recorded by a well-trained expert. For serological applications, the lack of standardization in endpoint interpretation and interference from non-specific inhibitors in clinical samples can translate into a high degree of variability in the results...
2017: PloS One
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