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Migraine aura

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https://www.readbyqxmd.com/read/29778452/cognitive-performance-in-young-and-middle-aged-adults-with-migraine-investigating-the-correlation-with-white-matter-hyperintensities-and-psychological-symptoms
#1
Abdulkadir Tunç, Aysel Kaya Tekeşin, Belma Doğan Güngen, Esra Arda
INTRODUCTION: This study aimed to evaluate the cognitive performance of migraine patients with (MwA) and without aura (MwoA) and investigate the correlation of white matter hyperintensities (WMHs) and psychological symptoms with their cognitive test scores. MATERIAL AND METHODS: Hundred migraine patients aged 20-55 years and 80 healthy volunteers with similar age, sex, and education level were enrolled. The total Montreal Cognitive Assessment (MoCA) scores were compared by age, sex, presence of aura, migraine duration, attack frequency, pain localization, presence and number of WMHs, and the scores of the Beck Depression Inventory and the Beck Anxiety Inventory (BAI)...
May 8, 2018: Neurologia i Neurochirurgia Polska
https://www.readbyqxmd.com/read/29777478/the-relationship-with-restless-legs-syndrome-fibromyalgia-and-depressive-symptoms-in-migraine-patients
#2
Zehra Akdag Uzun, Semiha Kurt, Hatice Karaer Unaldi
OBJECTIVE: In this study, we aimed to investigate restless legs syndrome, depression, frequency of fibromyalgia and possible causes of its frequencies, and the relationships among these synergies and migraine's prodrome, aura, pain, and postdrome symptoms in patients with migraine. SUBJECTS AND METHODS: The study group included 200 patients previously or recently diagnosed with definite migraine and according to International Headache Society criteria and 200 healthy volunteers...
May 18, 2018: Neurological Sciences
https://www.readbyqxmd.com/read/29768938/double-blind-placebo-controlled-randomized-clinical-trial-of-ginger-zingiber-officinale-rosc-addition-in-migraine-acute-treatment
#3
Laís Bhering Martins, Ana Maria Dos Santos Rodrigues, Débora Fernandes Rodrigues, Luana Caroline Dos Santos, Antônio Lúcio Teixeira, Adaliene Versiani Matos Ferreira
Background Previous studies have demonstrated the analgesic effects of ginger in different conditions, but evidence about its efficacy in migraine treatment is scarce. Objective This study aimed to evaluate the potential of ginger to improve acute migraine as an add-on strategy to standard treatment. Methods A double-blind placebo-controlled randomized clinical trial in the emergency room of a general hospital was conducted. Patients who sought medical care at the time of migraine attack were enrolled in this study...
January 1, 2018: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/29762872/the-effect-of-onabotulinumtoxina-on-aura-frequency-and-severity-in-patients-with-hemiplegic-migraine-case-series-of-11-patients
#4
Tiffany Y Chen, Ivan Garza, David W Dodick, Carrie E Robertson
BACKGROUND: OnabotulinumtoxinA has been demonstrated to be effective for the preventive treatment of headache in individuals with chronic migraine and has been approved and recommended for this patient population. While the therapeutic effect of onabotulinumtoxinA on migraine headache is well documented, there is limited information on the effect of onabotulinumtoxinA on migraine aura. OBJECTIVE: Given the prolonged and often debilitating nature of aura in patients with hemiplegic migraine, our group sought to examine the effect of onabotulinumtoxinA on aura frequency and severity in this specific subset of migraine patients...
May 15, 2018: Headache
https://www.readbyqxmd.com/read/29760572/breath-powered-sumatriptan-dry-nasal-powder-an-intranasal-medication-delivery-system-for-acute-treatment-of-migraine
#5
REVIEW
Stewart J Tepper, Merrilee R Johnstone
There is a need for fast-acting, non-oral medication options for migraine because some attacks develop rapidly and some are accompanied by nausea, vomiting, and gastroparesis, which can hinder oral medication uptake and absorption. The most commonly prescribed migraine medications are oral triptans, with sumatriptan as the most common. However, oral triptans are associated with adverse events (AEs) of atypical sensations that may be problematic for patients. Subcutaneous (SC) injectable sumatriptan and conventional liquid triptan nasal spray formulations are also available, but the frequency of atypical sensations is the highest with SC sumatriptan, and the intense bitter taste of conventional liquid triptan nasal spray discourages use...
2018: Medical Devices: Evidence and Research
https://www.readbyqxmd.com/read/29756582/polypharmacology-approach-against-migraine-with-aura-and-brain-edema-for-the-development-of-an-efficient-inhibitor-and-its-analogues
#6
Samawia Rizwan, Asim Mehmood, Irum Khalid, Muhammad Saad Khan, Qudsia Yousafi, Hayssam M Ali, Mohamed S Elshikh, Saima Kalsoom, Hamid Rashid
Polypharmacology is a design or use of pharmaceutical agents in which single drug is used to treat multiple diseases. Aquaporin proteins are identified to treat migraine with aura and brain edema. This study focuses on Aquaporin-1 and Aquaporin-4. AQP-1 is expressed in small afferent sensory nerve fibers. Over-expression of peripheral nervous system causes migraine. AQP-4 is an abundant channel water protein in brain that regulates water transport to prevent homeostasis. Over-expression of AQP-4 contributes to water imbalance in ischemic pathology resulting in cerebral edema...
May 13, 2018: Current Computer-aided Drug Design
https://www.readbyqxmd.com/read/29748452/influence-of-allergic-rhinitis-in-children-and-adolescents-with-recurrent-headache
#7
Francesco Maria Passali, Maria Carla Spinosi, Giulia Mignacco, Cemal Cingi, Hugo Anibal Rodriguez, Desiderio Passali
INTRODUCTION: Migraine and allergies are a common occurrence. The aim of this study was to investigate the relationship between respiratory allergy and migraine in childhood. MATERIALS AND METHODS: We screened 800 children for headache and its characteristics. After that we investigated the presence of allergy performing prick tests, rhinoscopy, endoscopy, rhinomanometry, cytology and mucociliary clearance tests. RESULTS: Out of 800 children screened, 96 suffered from headache...
April 30, 2018: Otolaryngologia Polska
https://www.readbyqxmd.com/read/29740328/emerging-role-of-endo-cannabinoids-in-migraine
#8
REVIEW
Pinja Leimuranta, Leonard Khiroug, Rashid Giniatullin
In this mini-review, we summarize recent discoveries and present new hypotheses on the role of cannabinoids in controlling trigeminal nociceptive system underlying migraine pain. Individual sections of this review cover key aspects of this topic, such as: (i) the current knowledge on the endocannabinoid system (ECS) with emphasis on expression of its components in migraine related structures; (ii) distinguishing peripheral from central site of action of cannabinoids, (iii) proposed mechanisms of migraine pain and control of nociceptive traffic by cannabinoids at the level of meninges and in brainstem, (iv) therapeutic targeting in migraine of monoacylglycerol lipase and fatty acid amide hydrolase, enzymes which control the level of endocannabinoids; (v) dual (possibly opposing) actions of cannabinoids via anti-nociceptive CB1 and CB2 and pro-nociceptive TRPV1 receptors...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29740217/acupuncture-therapy-in-treating-migraine-results-of-a-magnetic-resonance-spectroscopy-imaging-study
#9
Tao Gu, Lei Lin, Yun Jiang, Juan Chen, Ryan Cn D'Arcy, Min Chen, Xiaowei Song
Background: Acupuncture has been proven to be effective as an alternative therapy in treating migraine, but the pathophysiological mechanisms of the treatment remain unclear. This study investigated possible neurochemical responses to acupuncture treatment. Patients and methods: Proton magnetic resonance spectroscopy imaging was used to investigate biochemical levels pre- and post-acupuncture treatment. Participants (N=45) included subjects diagnosed with: 1) migraine without aura; 2) cervicogenic headache; and 3) healthy controls...
2018: Journal of Pain Research
https://www.readbyqxmd.com/read/29738351/more-than-meets-the-eye-the-eye-and-migraine-what-you-need-to-know
#10
Kathleen B Digre
Migraine has long been associated with disturbances of vision, especially migraine with aura. However, the eye plays an important role in sensory processing as well. We have found that the visual quality of life is reduced in migraine. In this review, we discuss how the migraine and eye pain pathways are similar and affect many of the common complaints which are seen in ophthalmology and neuro-ophthalmology offices, such as dry eye and postoperative eye pain. We also review other related phenomena, including visual snow and photophobia, which also are related to altered sensory processing in migraine...
June 2018: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
https://www.readbyqxmd.com/read/29732930/cephalic-cutaneous-allodynia-in-children-and-adolescents-with-migraine-of-short-duration-a-retrospective-cohort-study
#11
Yoel Levinsky, Avraham Zeharia, Tal Eidlitz-Markus
Background Allodynia is prevalent in adults with migraine and has been associated with long disease duration and severe course. Studies of the pediatric population are sparse. The aim of this study was to evaluate the rate of cephalic cutaneous allodynia in children and adolescents within the first 6 months of migraine onset and to identify associated clinical and migraine-related parameters. Methods The electronic database of a tertiary pediatric headache clinic from 2014 to 2017 was retrospectively searched for all children and adolescents diagnosed with migraine headache within 6 months or less of symptom onset...
January 1, 2018: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/29731251/common-variant-burden-contributes-to-the-familial-aggregation-of-migraine-in-1-589-families
#12
Padhraig Gormley, Mitja I Kurki, Marjo Eveliina Hiekkala, Kumar Veerapen, Paavo Häppölä, Adele A Mitchell, Dennis Lal, Priit Palta, Ida Surakka, Mari Anneli Kaunisto, Eija Hämäläinen, Salli Vepsäläinen, Hannele Havanka, Hanna Harno, Matti Ilmavirta, Markku Nissilä, Erkki Säkö, Marja-Liisa Sumelahti, Jarmo Liukkonen, Matti Sillanpää, Liisa Metsähonkala, Seppo Koskinen, Terho Lehtimäki, Olli Raitakari, Minna Männikkö, Caroline Ran, Andrea Carmine Belin, Pekka Jousilahti, Verneri Anttila, Veikko Salomaa, Ville Artto, Markus Färkkilä, Heiko Runz, Mark J Daly, Benjamin M Neale, Samuli Ripatti, Mikko Kallela, Maija Wessman, Aarno Palotie
Complex traits, including migraine, often aggregate in families, but the underlying genetic architecture behind this is not well understood. The aggregation could be explained by rare, penetrant variants that segregate according to Mendelian inheritance or by the sufficient polygenic accumulation of common variants, each with an individually small effect, or a combination of the two hypotheses. In 8,319 individuals across 1,589 migraine families, we calculated migraine polygenic risk scores (PRS) and found a significantly higher common variant burden in familial cases (n = 5,317, OR = 1...
April 27, 2018: Neuron
https://www.readbyqxmd.com/read/29731052/a-38-year-old-woman-with-global-aphasia-and-migraine
#13
Jialei Yang, Xiaoyong Huang, Shimin Yin, Lei Wang, Mingyang Zhou
A 38-year-old right-handed woman presented to the hospital with subtle right facial palsy and global aphasia of 4 days' duration. She found that she had aphasia when she suddenly woke up at midnight and reported a headache lasting for several hours. She had no fever, vomiting, seizures, or limb paralysis. She had had migraines with an occasional visual aura for > 10 years. She was not taking any medication and was a nondrinker and nonsmoker. She had no other significant medical background and family history...
May 2018: Chest
https://www.readbyqxmd.com/read/29725183/dihydroergotamine-complicating-reversible-cerebral-vasoconstriction-syndrome-in-status-migrainosus
#14
Naresh Mullaguri, Madihah Hepburn, Christopher Ryan Newey, Premkumar Chandrasekharan Nattanmai
Reversible cerebral vasoconstriction syndrome (RCVS) is a clinicoradiological syndrome that occurs due to dysfunction of cerebrovascular autoregulation. It is characterized by recurrent thunderclap headache from cerebral vasoconstriction which can cause ischemic infarction, spontaneous intraparenchymal and subarachnoid hemorrhage. This syndrome can be triggered by a variety of etiologies including medications, infectious, and inflammatory conditions. The diagnosis is often delayed due to unawareness among the health-care providers and delayed neuroimaging evidence of vasoconstriction with or without ischemic and/or hemorrhagic infarction...
April 2018: Journal of Neurosciences in Rural Practice
https://www.readbyqxmd.com/read/29722303/harnessing-migraines-for-neural-regeneration
#15
REVIEW
Jonathan M Borkum
The success of naturalistic or therapeutic neuroregeneration likely depends on an internal milieu that facilitates the survival, proliferation, migration, and differentiation of stem cells and their assimilation into neural networks. Migraine attacks are an integrated sequence of physiological processes that may protect the brain from oxidative stress by releasing growth factors, suppressing apoptosis, stimulating neurogenesis, encouraging mitochondrial biogenesis, reducing the production of oxidants, and upregulating antioxidant defenses...
April 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/29719223/the-transient-receptor-potential-ankyrin-type-1-plays-a-critical-role-in-cortical-spreading-depression
#16
Liwen Jiang, Yan Wang, Yuewei Xu, Dongqing Ma, Minyan Wang
The transient receptor potential ankyrin type-1 (TRPA1) channels have been proposed as a potential target for migraine therapy. Yet the role of cortical TRPA1 channels in migraine mechanism has not been fully understood. Cortical spreading depression (CSD) is known as an underlying cause of migraine aura. The aim of this study is to investigate if cortical TRPA1 activity is required for CSD genesis and propagation. A mouse brain slice CSD model with intrinsic optical imaging was applied for TRPA1 signaling pharmacology...
April 29, 2018: Neuroscience
https://www.readbyqxmd.com/read/29706439/recognition-of-cerebral-autosomal-dominant-arteriopathy-with-subcortical-infarcts-and-leukoencephalopathy-cadasil-in-two-oligosymptomatic-sisters-with-low-cadasil-scale-scores-and-a-venous-dysplasia-report-of-a-novel-greek-family
#17
George P Paraskevas, Vasilios C Constantinides, Christos Yapijakis, Evangelia Kararizou, Elisabeth N Kapaki, Anastasia Bougea
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) due to mutations of the NOTCH3 gene is the most common cause of inherited cerebral small-vessel disease and one of the genetic causes of migraine with aura. The so-called CADASIL scale has been proposed as a clinical screening tool, and a score of 15 or higher seems useful in identifying patients with high probability of carrying NOTCH3 mutations. We studied a novel Greek family with clinical features compatible with CADASIL...
April 26, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29706311/the-association-between-obesity-and-migraine-in-a-population-of-iranian-adults-a-case-control-study
#18
Ali Miri, Morteza Nasiri, Sahar Zonoori, Fatemeh Yarahmad, Arasb Dabbagh-Moghadam, Gholamreza Askari, Omid Sadeghi, Masoumeh Asadi
AIM: To assess the association between obesity and risk of migraine with aura and features of migraine attacks among a population of Iranian adults. METHODS: In this case-control study, 102 confirmed cases of migraine with aura were matched based on age and gender with 102 healthy subjects. Data on demographic characteristics and anthropometric measurements were collected from all cases and controls by the same methods. Overweight and obesity were considered as body mass index ≥25-30 kg/m2 and ≥ 30 kg/m2 , respectively...
April 12, 2018: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/29703787/dissociation-between-csd-evoked-metabolic-perturbations-and-meningeal-afferent-activation-and-sensitization-implications-for-mechanisms-of-migraine-headache-onset
#19
Jun Zhao, Dan Levy
The onset of the headache phase during attacks of migraine with aura, which occur in about 30% of migraineurs, is believed to involve cortical spreading depression (CSD) and the ensuing activation and sensitization of primary afferent neurons that innervate the intracranial meninges, and their related large vessels. The mechanism by which CSD enhances the activity and mechanosensitivity of meningeal afferents remains poorly understood, but may involve cortical metabolic perturbations. We employed extracellular single-unit recording of meningeal afferent activity and monitored changes in cortical blood flow and tissue partial pressure of oxygen (tpO2 ) in anesthetized male rats to test whether the prolonged cortical hypoperfusion and reduction in tissue oxygenation that occur in the wake of CSD contribute to meningeal nociception...
April 27, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29697154/a-phase-by-phase-review-of-migraine-pathophysiology
#20
David W Dodick
Migraine is a common, disabling neurological disorder characterized by multiple phases: premonitory, aura, headache, postdrome, and interictal. Our understanding of the pathophysiology of each phase of migraine has evolved over recent years. The premonitory phase begins as early as 3 days before the headache phase, and involves a complex interplay between various cortical and subcortical brain regions, including the hypothalamus and brainstem nuclei that modulate nociceptive signaling. The headache phase involves activation of the trigeminovascular system, a pathway that is well characterized...
May 2018: Headache
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