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https://www.readbyqxmd.com/read/29154684/brain-functional-connectivity-in-headache-disorders-a-narrative-review-of-mri-investigations
#1
Catherine D Chong, Todd J Schwedt, Anders Hougaard
Resting-state functional magnetic resonance imaging (rs-fMRI) is used to interrogate the functional connectivity and network organization amongst brain regions. Functional connectivity is determined by measuring the extent of synchronization in the spontaneous fluctuations of blood oxygenation level dependent (BOLD) signal. Here, we review current rs-fMRI studies in headache disorders including migraine, trigeminal autonomic cephalalgias, and medication overuse headache. We discuss (1) brain network alterations that are shared amongst the different headache disorders and (2) network abnormalities distinct to each headache disorder...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/29148276/correction-to-albury-et-al-re-six-novel-rare-non-synonymous-mutations-for-migraine-without-aura-identified-by-exome-sequencing
#2
(no author information available yet)
No abstract text is available yet for this article.
November 17, 2017: Journal of Neurogenetics
https://www.readbyqxmd.com/read/29146952/migrainomics-identifying-brain-and-genetic-markers-of-migraine
#3
REVIEW
Dale R Nyholt, David Borsook, Lyn R Griffiths
Migraine is one of the world's most prevalent and disabling disorders and imposes an enormous socioeconomic burden. The exact causes of migraine are unknown, and no recognizable diagnostic pathological changes have been identified. Specific identifiable markers of migraine would aid diagnosis and could provide insight into the pathogenesis of the condition, with the potential to direct development of new therapeutics. In the past few years, advances in neuroimaging and genetic studies have provided the most substantial progress towards the identification of markers...
November 17, 2017: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/29146234/the-value-of-patient-directed-brain-mri-scan-with-a-diagnosis-of-migraine
#4
William J Mullally, Kathryn E Hall
OBJECTIVE: To determine if a brain MRI scan in patients with a diagnosis of migraine, who insist on the performance of imaging, is of more benefit in detecting clinically significant unsuspected structural abnormalities than would be expected by chance. METHODS: This prospective, observational, single center study was performed from January 1, 2010 to December 31,2012 and included 100 subjects with a diagnosis of migraine and a normal neurologic exam. A brain MRI scan was performed on all patients, solely at their request, to detect an unsuspected clinically significant structural lesion...
November 13, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/29143861/migraine-with-prolonged-aura-phenotype-and-treatment
#5
REVIEW
Michele Viana, Shazia Afridi
We review the published literature on migraine with prolonged aura (PA), specifically with regards to the phenotype and treatment options. PA is not uncommon. A recent study found that about 17% of migraine auras are prolonged and that 26% of patients with migraine with aura have experienced at least one PA. The characteristics of PA are similar to most typical auras with the exception of a higher number of aura symptoms (in particular sensory and/or dysphasic). There are no well-established treatments at present which target the aura component of migraine...
November 16, 2017: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/29143207/contribution-of-eeg-in-transient-neurological-deficits
#6
Pierre Lozeron, Nadine Carole Tcheumeni, Sahar Turki, Hélène Amiel, Elodie Meppiel, Sana Masmoudi, Caroline Roos, Isabelle Crassard, Patrick Plaisance, Houria Benbetka, Jean-Pierre Guichard, Emmanuel Houdart, Hélène Baudoin, Nathalie Kubis
Identification of stroke mimics and 'chameleons' among transient neurological deficits (TND) is critical. Diagnostic workup consists of a brain imaging study, for a vascular disease or a brain tumour and EEG, for epileptiform discharges. The precise role of EEG in this diagnostic workup has, however, never been clearly delineated. However, this could be crucial in cases of atypical or incomplete presentation with consequences on disease management and treatment. We analysed the EEG patterns on 95 consecutive patients referred for an EEG within 7 days of a TND with diagnostic uncertainty...
November 15, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/29139115/risk-of-stroke-associated-with-use-of-estrogen-containing-contraceptives-in-women-with-migraine-a-systematic-review
#7
REVIEW
Huma U Sheikh, Jelena Pavlovic, Elizabeth Loder, Rebecca Burch
OBJECTIVE: Migraine with aura has been associated with increased risk of ischemic and hemorrhagic stroke. Prior studies have shown a further increase in risk in women using combined hormonal contraceptives (CHCs). This has led to guidelines recommending against use of CHCs in this population. We sought to assess whether the risk of stroke is associated with the dose of estrogen and whether there is evidence of synergism between migraine and CHCs. We also sought to assess whether an interaction effect exists between migraine and CHCs...
November 15, 2017: Headache
https://www.readbyqxmd.com/read/29130510/heterogenous-migraine-aura-symptoms-correlate-with-visual-cortex-fmri-responses
#8
Nanna Arngrim, Anders Hougaard, Khazar Ahmadi, Mark Bitsch Vestergaard, Henrik Winther Schytz, Faisal Mohammad Amin, Henrik Bo Wiberg Larsson, Jes Olesen, Michael B Hoffmann, Messoud Ashina
OBJECTIVE: Migraine aura is sparsely studied due to the highly challenging task of capturing patients during aura. Cortical spreading depression (CSD) is likely the underlying phenomenon of aura. The possible correlation between the multifaceted phenomenology of aura symptoms and the effects of CSD on the brain has not been ascertained. METHODS: Five migraine patients were studied during various forms of aura symptoms induced by hypoxia, sham or physical exercise and photostimulation...
November 11, 2017: Annals of Neurology
https://www.readbyqxmd.com/read/29126355/elevated-circulating-endothelial-specific-micrornas-in-migraine-patients-a-pilot-study
#9
Chun-Yu Cheng, Shih-Pin Chen, Yi-Chu Liao, Jong-Ling Fuh, Yen-Feng Wang, Shuu-Jiun Wang
Background Evidence of vascular dysfunction in migraine is increasing. MicroRNAs (miRs) have emerged as important regulators of vascular endothelial functions. This exploratory study investigated whether circulating levels of miRs associated with endothelial function are altered in migraine patients. Methods Thirty patients with migraine (20-50 years old) without overt vascular risk factors and 30 sex- and age-matched healthy controls participated. The levels of four miRs that regulate endothelial function (miR-155, miR-126, miR-21, and Let-7g) were quantified and expressed in terms of fold changes (2(-ΔΔct)) relative to mean levels in the control group...
January 1, 2017: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/29111146/medical-contraindications-to-estrogen-and-contraceptive-use-among-women-veterans
#10
Colleen P Judge, Xinhua Zhao, Florentina E Sileanu, Maria K Mor, Sonya Borrero
BACKGROUND: Women veterans have high rates of medical comorbidities and may be particularly vulnerable to adverse health outcomes associated with unintended pregnancy. OBJECTIVES: The objective of the study was to estimate the prevalence of medical contraindications to estrogen-containing combined hormonal contraception among women veterans of reproductive age and to evaluate the relationship between contraindications and contraceptive use. STUDY DESIGN: This was a secondary analysis of data from a cross-sectional, telephone-based survey with a national sample of 2302 female veterans, aged 18-45 years, who use the Veterans Administration Healthcare System for primary care...
October 27, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29105529/re-six-novel-rare-non-synonymous-mutations-for-migraine-without-aura-identified-by-exome-sequencing
#11
Cassie L Albury, Zachary Gerring, Lyn R Griffiths, Dale R Nyhol, Astrid J Rodriguez-Acevedo
No abstract text is available yet for this article.
November 6, 2017: Journal of Neurogenetics
https://www.readbyqxmd.com/read/29076927/the-etiological-relationship-between-migraine-and-sudden-hearing-loss
#12
Yildiz Arslan, İlker Burak Arslan, Huriye Aydin, Özlem Yağiz, Figen Tokuçoğlu, İbrahim Çukurova
OBJECTIVES: To investigate the relationship between sudden sensorineural hearing loss (SSNHL) and migraine, assess the prevalence of migraine in patients with idiopathic SSNHL, and determine a possible common vascular etiopathogenesis for migraine and SSNHL. STUDY DESIGN: Prospective cohort study. SETTING: Tertiary referral center. PATIENTS: This study initially assessed 178 SSNHL cases obtained from the Head and Neck Surgery Clinic patient database at a tertiary hospital in Turkey between January 2011 and March 2016...
December 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/29073774/migraine-with-brainstem-aura-why-not-a-cortical-origin
#13
Geneviève Demarquay, Anne Ducros, Alexandra Montavont, François Mauguiere
Background Migraine with brainstem aura is defined as a migraine with aura including at least two of the following symptoms: dysarthria, vertigo, tinnitus, hypacusis, diplopia, ataxia and/or decreased level of consciousness. Aim The aim of this study is to review data coming from clinical observations and functional mapping that support the role of the cerebral cortex in the initiation of brainstem aura symptoms. Results Vertigo can result from a vestibular cortex dysfunction, while tinnitus and hypacusis can originate within the auditory cortex...
January 1, 2017: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/29066757/impaired-k-binding-to-glial-glutamate-transporter-eaat1-in-migraine
#14
Peter Kovermann, Margarita Hessel, Daniel Kortzak, Joanna C Jen, Johannes Koch, Christoph Fahlke, Tobias Freilinger
SLC1A3 encodes the glial glutamate transporter hEAAT1, which removes glutamate from the synaptic cleft via stoichiometrically coupled Na(+)-K(+)-H(+)-glutamate transport. In a young man with migraine with aura including hemiplegia, we identified a novel SLC1A3 mutation that predicts the substitution of a conserved threonine by proline at position 387 (T387P) in hEAAT1. To evaluate the functional effects of the novel variant, we expressed the wildtype or mutant hEAAT1 in mammalian cells and performed whole-cell patch clamp, fast substrate application, and biochemical analyses...
October 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29063453/right-to-left-shunt-may-be-prone-to-affect-the-white-matter-integrity-of-posterior-circulation-in-migraine-without-aura
#15
Hui Xie, Yitong Bian, Zhijie Jian, Kang Huo, Rui Liu, Dan Zhu, Lihui Zhang, Jun Wu, Jian Yang, Jixin Liu, Guogang Luo
Numerous studies have indicated an association between migraine and right-to-left shunt. However, little is known about whether right-to-left shunt has an effect on the migraine brain. This observational study aims to explore the impact of right-to-left shunt on the brain of migraine without aura on microstructural level. Thirty-five patients with migraine without aura were enrolled in this study. Contrast-enhanced Transcranial Doppler was performed to evaluate the status of right-to-left shunt. Three-dimensional T1-weighted and diffusion tensor images were acquired for data analysis...
October 23, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/29063211/physiopathology-of-migraine-what-have-we-learned-from-functional-imaging
#16
REVIEW
Antonio Russo, Marcello Silvestro, Gioacchino Tedeschi, Alessandro Tessitore
PURPOSE OF REVIEW: This review aims to provide an overview of the most recent and significant functional neuroimaging studies which have clarified the complex mechanisms underlying migraine pathophysiology. RECENT FINDINGS: The recent data allow us to overcome the concept of a migraine generator suggesting that functional networks abnormalities may lead to changes in different brain area activities and consequent reduced migraine thresholds susceptibility, likely associated with higher migraine severity and burden...
October 23, 2017: Current Neurology and Neuroscience Reports
https://www.readbyqxmd.com/read/29062375/a-report-of-a-novel-mutation-in-human-prostacyclin-receptor-gene-in-patients-affected-with-migraine
#17
Majid Kheirollahi, Mohammad Reza Pourreza, Fariborz Khorvash, Mohammad Kazemi, Gilda Amini
Objective: The human prostacyclin receptor gene encodes the human prostacyclin receptor, which is a part of the vasodilator system, during migraine attacks and almost certainly plays an important role in the mechanism of this disease. Method: The present study aimed at determining any variants in PTGIR gene by means of PCR and direct sequencing. Blood samples were taken from the patients, and genomic DNA was extracted. Polymerase chain reaction was performed on the extracted DNA. The PCR products were then sequenced using the Sanger method...
July 2017: Iranian Journal of Psychiatry
https://www.readbyqxmd.com/read/29059314/foveal-and-peripapillary-vascular-decrement-in-migraine-with-aura-demonstrated-by-optical-coherence-tomography-angiography
#18
COMPARATIVE STUDY
Melinda Y Chang, Nopasak Phasukkijwatana, Sean Garrity, Stacy L Pineles, Mansour Rahimi, David Sarraf, Mollie Johnston, Andrew Charles, Anthony C Arnold
Purpose: Migraine, particularly with aura, has been associated with ocular and systemic ischemic complications, but there are limited data on the ocular vasculature in migraine. We used optical coherence tomography angiography (OCTA) to assess perfusion of the macula and optic nerve in migraine patients, with (MA) and without (MO) aura, compared to healthy controls (HC). Methods: We recruited 15 MA (mean age 42 years), 12 MO (mean age 46 years), and 22 HC (mean age 39 years) participants from neurology and neuro-ophthalmology clinics...
October 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29058954/migraine-and-cognitive-function-baseline-findings-from-the-brazilian-longitudinal-study-of-adult-health-elsa-brasil
#19
Cristina Pellegrino Baena, Alessandra Carvalho Goulart, Itamar de Souza Santos, Claudia Kimie Suemoto, Paulo Andrade Lotufo, Isabela Judith Bensenor
Background The association between migraine and cognitive performance is unclear. We analyzed whether migraine is associated with cognitive performance among participants of the Brazilian Longitudinal Study of Adult Health, ELSA-Brasil. Methods Cross-sectional analysis, including participants with complete information about migraine and aura at baseline. Headache status (no headaches, non-migraine headaches, migraine without aura and migraine with aura), based on the International Headache Society classification, was used as the dependent variable in the multilinear regression models, using the category "no headache" as reference...
January 1, 2017: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/29044546/associations-between-depression-anxiety-and-headache-frequency-in-migraineurs-a-cross-sectional-study
#20
Hsuan-Te Chu, Chih-Sung Liang, Jiunn-Tay Lee, Ta-Chuan Yeh, Meei-Shyuan Lee, Yueh-Feng Sung, Fu-Chi Yang
BACKGROUND: While migraines have been associated with emotional disturbances, it remains unknown whether the intensity of emotional expression is directly related to migraine frequency. OBJECTIVE: The present study investigated depression/anxiety among migraineurs. METHODS: This cross-sectional study included 588 clinical outpatients in Taiwan. Migraines were stratified by attack frequency, with and without auras, and with well-controlled confounding variables...
October 18, 2017: Headache
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