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Lung cancer metabolomics

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https://www.readbyqxmd.com/read/28061019/metabolic-phenotyping-of-human-plasma-by-1-h-nmr-at-high-and-medium-magnetic-field-strengths-a-case-study-for-lung-cancer
#1
Louis Evelyne, Francois-Xavier Cantrelle, Liesbet Mesotten, Gunter Reekmans, Liene Bervoets, Karolien Vanhove, Michiel Thomeer, Guy Lippens, Peter Adriaensens
Accurate identification and quantification of human plasma metabolites can be challenging in crowded regions of the NMR spectrum with severe signal overlap. Therefore, this study describes metabolite spiking experiments on the basis of which the NMR spectrum can be rationally segmented into well-defined integration regions, and this for spectrometers having magnetic field strengths corresponding to (1) H resonance frequencies of 400 MHz and 900 MHz. Subsequently, the integration data of a case-control dataset of 69 lung cancer patients and 74 controls were used to train a multivariate statistical classification model for both field strengths...
January 6, 2017: Magnetic Resonance in Chemistry: MRC
https://www.readbyqxmd.com/read/28049629/integrated-metabolomics-and-proteomics-highlight-altered-nicotinamide-and-polyamine-pathways-in-lung-adenocarcinoma
#2
REVIEW
Johannes F Fahrmann, Dmitry D Grapov, Kwanjeera Wanichthanarak, Brian C DeFelice, Michelle R Salemi, William N Rom, David R Gandara, Brett S Phinney, Oliver Fiehn, Harvey Pass, Suzanne Miyamoto
Lung cancer is the leading cause of cancer mortality in the United States with non-small cell lung cancer (NSCLC) adenocarcinoma being the most common histological type. Early perturbations in cellular metabolism are a hallmark of cancer, but the extent of these changes in early stage lung adenocarcinoma remains largely unknown. In the current study, an integrated metabolomics and proteomics approach was utilized to characterize the biochemical and molecular alterations between malignant and matched control tissue from 27 subjects diagnosed with early stage lung adenocarcinoma...
January 3, 2017: Carcinogenesis
https://www.readbyqxmd.com/read/27903834/saliva-diagnostics-current-views-and-directions
#3
Karolina Elżbieta Kaczor-Urbanowicz, Carmen Martin Carreras-Presas, Katri Aro, Michael Tu, Franklin Garcia-Godoy, David Tw Wong
In this review, we provide an update on the current and future applications of saliva for diagnostic purposes. There are many advantages of using saliva as a biofluid. Its collection is fast, easy, inexpensive, and non-invasive. In addition, saliva, as a "mirror of the body," can reflect the physiological and pathological state of the body. Therefore, it serves as a diagnostic and monitoring tool in many fields of science such as medicine, dentistry, and pharmacotherapy. Introduced in 2008, the term "Salivaomics" aimed to highlight the rapid development of knowledge about various "omics" constituents of saliva, including: proteome, transcriptome, micro-RNA, metabolome, and microbiome...
November 29, 2016: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/27810772/fourier-transform-infra-red-spectroscopic-signatures-for-lung-cells-epithelial-mesenchymal-transition-a-preliminary-report
#4
Atasi Sarkar, Sanghamitra Sengupta, Anirban Mukherjee, Jyotirmoy Chatterjee
Infra red (IR) spectral characterization can provide label-free cellular metabolic signatures of normal and diseased circumstances in a rapid and non-invasive manner. Present study endeavoured to enlist Fourier transform infra red (FTIR) spectroscopic signatures for lung normal and cancer cells during chemically induced epithelial mesenchymal transition (EMT) for which global metabolic dimension is not well reported yet. Occurrence of EMT was validated with morphological and immunocytochemical confirmation...
February 15, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/27788581/environmental-tobacco-smoke-alters-metabolic-systems-in-adult-rats
#5
Dinesh K Barupal, Kent E Pinkerton, Carol Hood, Tobias Kind, Oliver Fiehn
Human exposure to environmental tobacco smoke (ETS) is associated with an increased incidence of pulmonary and cardiovascular disease and possibly lung cancer. Metabolomics can reveal changes in metabolic networks in organisms under different physio-pathological conditions. Our objective was to identify spatial and temporal metabolic alterations with acute and repeated subchronic ETS exposure to understand mechanisms by which ETS exposure may cause adverse physiological and structural changes in the pulmonary and cardiovascular systems...
November 21, 2016: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/27775075/myoferlin-regulates-cellular-lipid-metabolism-and-promotes-metastases-in-triple-negative-breast-cancer
#6
A Blomme, B Costanza, P de Tullio, M Thiry, G Van Simaeys, S Boutry, G Doumont, E Di Valentin, T Hirano, T Yokobori, S Gofflot, O Peulen, A Bellahcène, F Sherer, C Le Goff, E Cavalier, A Mouithys-Mickalad, F Jouret, P G Cusumano, E Lifrange, R N Muller, S Goldman, P Delvenne, E De Pauw, M Nishiyama, V Castronovo, A Turtoi
Myoferlin is a multiple C2-domain-containing protein that regulates membrane repair, tyrosine kinase receptor function and endocytosis in myoblasts and endothelial cells. Recently it has been reported as overexpressed in several cancers and shown to contribute to proliferation, migration and invasion of cancer cells. We have previously demonstrated that myoferlin regulates epidermal growth factor receptor activity in breast cancer. In the current study, we report a consistent overexpression of myoferlin in triple-negative breast cancer cells (TNBC) over cells originating from other breast cancer subtypes...
October 24, 2016: Oncogene
https://www.readbyqxmd.com/read/27673363/serum-metabolomic-profiling-of-prostate-cancer-risk-in-the-prostate-lung-colorectal-and-ovarian-cancer-screening-trial
#7
Jiaqi Huang, Alison M Mondul, Stephanie J Weinstein, Stella Koutros, Andriy Derkach, Edward Karoly, Joshua N Sampson, Steven C Moore, Sonja I Berndt, Demetrius Albanes
BACKGROUND: Two recent metabolomic analyses found serum lipid, energy, and other metabolites related to aggressive prostate cancer risk up to 20 years prior to diagnosis. METHODS: We conducted a serum metabolomic investigation of prostate cancer risk in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial that included annual serum total prostate-specific antigen measurement and digital rectal examination. This nested study included 380 cases diagnosed post-screening and 380 controls individually matched to cases on age, race, study centre, and blood-collection date (median time to diagnosis, 10 years (range 4...
October 25, 2016: British Journal of Cancer
https://www.readbyqxmd.com/read/27662884/implementation-of-a-multicenter-biobanking-collaboration-for-next-generation-sequencing-based-biomarker-discovery-based-on-fresh-frozen-pretreatment-tumor-tissue-biopsies
#8
Sander Bins, Geert A Cirkel, Christa G Gadellaa-van Hooijdonk, Fleur Weeber, Isaac J Nijman, Annette H Bruggink, Paul J van Diest, Stefan M Willems, Wouter B Veldhuis, Michel M van den Heuvel, Rob J de Knegt, Marco J Koudijs, Erik van Werkhoven, Ron H J Mathijssen, Edwin Cuppen, Stefan Sleijfer, Jan H M Schellens, Emile E Voest, Marlies H G Langenberg, Maja J A de Jonge, Neeltje Steeghs, Martijn P Lolkema
BACKGROUND: The discovery of novel biomarkers that predict treatment response in advanced cancer patients requires acquisition of high-quality tumor samples. As cancer evolves over time, tissue is ideally obtained before the start of each treatment. Preferably, samples are freshly frozen to allow analysis by next-generation DNA/RNA sequencing (NGS) but also for making other emerging systematic techniques such as proteomics and metabolomics possible. Here, we describe the first 469 image-guided biopsies collected in a large collaboration in The Netherlands (Center for Personalized Cancer Treatment) and show the utility of these specimens for NGS analysis...
September 23, 2016: Oncologist
https://www.readbyqxmd.com/read/27566571/non-targeted-and-targeted-metabolomics-approaches-to-diagnosing-lung-cancer-and-predicting-patient-prognosis
#9
Xiaoli Zhang, Xinyue Zhu, Caihong Wang, Haixia Zhang, Zhiming Cai
Lung cancer is the most common cause of cancer death in China. We characterized metabolic alterations in lung cancer using two analytical platforms: a non-targeted metabolic profiling strategy based on proton nuclear magnetic resonance (1H-NMR) spectroscopy and a targeted metabolic profiling strategy based on rapid resolution liquid chromatography (RRLC). Changes in serum metabolite levels during oncogenesis were evaluated in 25 stage I lung cancer patients and matched healthy controls. We identified 25 metabolites that were differentially regulated between the lung cancer patients and matched controls...
September 27, 2016: Oncotarget
https://www.readbyqxmd.com/read/27551682/distinctly-perturbed-metabolic-networks-underlie-differential-tumor-tissue-damages-induced-by-immune-modulator-%C3%AE-glucan-in-a-two-case-ex-vivo-non-small-cell-lung-cancer-study
#10
Teresa W-M Fan, Marc O Warmoes, Qiushi Sun, Huan Song, Jadwiga Turchan-Cholewo, Jeremiah T Martin, Angela Mahan, Richard M Higashi, Andrew N Lane
Cancer and stromal cell metabolism is important for understanding tumor development, which highly depends on the tumor microenvironment (TME). Cell or animal models cannot recapitulate the human TME. We have developed an ex vivo paired cancerous (CA) and noncancerous (NC) human lung tissue approach to explore cancer and stromal cell metabolism in the native human TME. This approach enabled full control of experimental parameters and acquisition of individual patient's target tissue response to therapeutic agents while eliminating interferences from genetic and physiological variations...
July 2016: Cold Spring Harbor Molecular Case Studies
https://www.readbyqxmd.com/read/27506545/high-resolution-metabolomics-to-discriminate-compounds-in-serum-of-male-lung-cancer-patients-in-south-korea
#11
Aryo D Pamungkas, Changyoung Park, Sungyong Lee, Sun Ha Jee, Youngja H Park
BACKGROUND: The cancer death rate escalated during 20th century. In South Korea, lung cancer is expected to contribute 12,736 deaths in men, the highest amount among all cancers. Several risk factors may increase the chance to acquiring lung cancer, with mostly related to exogenous compounds found in cigarette smoke and synthetic manufacturing materials. As the mortality rate of lung cancer increases, deeper understanding is necessary to explore risk factors that may lead to this malignancy...
2016: Respiratory Research
https://www.readbyqxmd.com/read/27489532/preclinical-models-for-interrogating-drug-action-in-human-cancers-using-stable-isotope-resolved-metabolomics-sirm
#12
Andrew N Lane, Richard M Higashi, Teresa W-M Fan
AIMS: In this review we compare the advantages and disadvantages of different model biological systems for determining the metabolic functions of cells in complex environments, how they may change in different disease states, and respond to therapeutic interventions. BACKGROUND: All preclinical drug-testing models have advantages and drawbacks. We compare and contrast established cell, organoid and animal models with ex vivo organ or tissue culture and in vivo human experiments in the context of metabolic readout of drug efficacy...
July 2016: Metabolomics: Official Journal of the Metabolomic Society
https://www.readbyqxmd.com/read/27423423/metabolomic-based-biomarker-discovery-for-non-invasive-lung-cancer-screening-a-case-study
#13
Keiron O'Shea, Simon J S Cameron, Keir E Lewis, Chuan Lu, Luis A J Mur
BACKGROUND: Lung cancer (LC) is one of the leading lethal cancers worldwide, with an estimated 18.4% of all cancer deaths being attributed to the disease. Despite developments in cancer diagnosis and treatment over the previous thirty years, LC has seen little to no improvement in the overall five year survival rate after initial diagnosis. METHODS: In this paper, we extended a recent study which profiled the metabolites in sputum from patients with lung cancer and age-matched volunteers smoking controls using flow infusion electrospray ion mass spectrometry...
November 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27403896/applicability-of-under-vacuum-fresh-tissue-sealing-and-cooling-to-omics-analysis-of-tumor-tissues
#14
Silvia Veneroni, Matteo Dugo, Maria Grazia Daidone, Egidio Iorio, Barbara Valeri, Patrizia Pinciroli, Maida De Bortoli, Edoardo Marchesi, Patrizia Miodini, Elena Taverna, Alessandro Ricci, Silvana Canevari, Giuseppe Pelosi, Italia Bongarzone
CONTEXT: Biobanks of frozen human normal and malignant tissues represent a valuable source for "omics" analysis in translational cancer research and molecular pathology. However, the success of molecular and cellular analysis strongly relies on the collection, handling, storage procedures, and quality control of fresh human tissue samples. OBJECTIVE: We tested whether under vacuum storage (UVS) effectively preserves tissues during the time between surgery and storage for "omics" analyses...
December 2016: Biopreservation and Biobanking
https://www.readbyqxmd.com/read/27341184/metabolomic-profiles-of-current-cigarette-smokers
#15
Ping-Ching Hsu, Renny S Lan, Theodore M Brasky, Catalin Marian, Amrita K Cheema, Habtom W Ressom, Christopher A Loffredo, Wallace B Pickworth, Peter G Shields
Smoking-related biomarkers for lung cancer and other diseases are needed to enhance early detection strategies and to provide a science base for tobacco product regulation. An untargeted metabolomics approach by ultra-performance liquid chromatography-quadrupole-time of flight mass spectrometry (UHPLC-Q-TOF MS) totaling 957 assays was used in a novel experimental design where 105 current smokers smoked two cigarettes 1 h apart. Blood was collected immediately before and after each cigarette allowing for within-subject replication...
February 2017: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/27335287/-development-of-precision-medicine-in-the-surgical-treatment-of-lung-cancer
#16
Fengwei Tan, Ning Li, Shugeng Gao, Jie He
Precision medicine is to developing the most appropriate individualized treatment for each patient based on the macro to the micro level of individual differences. Genomic, proteomics, metabolomics data, and other big data analysis methods are the essence of precision medicine. Precision medicine brings the hope to overcome cancer. Among all kinds of tumors, lung cancer is the biggest threat to human. This paper reviewed the development of precision medicine in the surgical treatment of lung cancer.
June 20, 2016: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
https://www.readbyqxmd.com/read/27330862/-1-h-nmr-studies-distinguish-the-water-soluble-metabolomic-profiles-of-untransformed-and-ras-transformed-cells
#17
Vered Marks, Anisleidys Munoz, Priyamvada Rai, Jamie D Walls
Metabolomic profiling is an increasingly important method for identifying potential biomarkers in cancer cells with a view towards improved diagnosis and treatment. Nuclear magnetic resonance (NMR) provides a potentially noninvasive means to accurately characterize differences in the metabolomic profiles of cells. In this work, we use (1)H NMR to measure the metabolomic profiles of water soluble metabolites extracted from isogenic control and oncogenic HRAS-, KRAS-, and NRAS-transduced BEAS2B lung epithelial cells to determine the robustness of NMR metabolomic profiling in detecting differences between the transformed cells and their untransformed counterparts as well as differences among the RAS-transformed cells...
2016: PeerJ
https://www.readbyqxmd.com/read/27316915/french-intensive-care-society-international-congress-r%C3%A3-animation-2016
#18
(no author information available yet)
No abstract text is available yet for this article.
June 2016: Annals of Intensive Care
https://www.readbyqxmd.com/read/27292634/targeting-tumor-mitochondrial-metabolism-overcomes-resistance-to-antiangiogenics
#19
Paloma Navarro, Maria J Bueno, Ivana Zagorac, Tamara Mondejar, Jesus Sanchez, Silvana Mourón, Javier Muñoz, Gonzalo Gómez-López, Veronica Jimenez-Renard, Francisca Mulero, Navdeep S Chandel, Miguel Quintela-Fandino
Epithelial malignancies are effectively treated by antiangiogenics; however, acquired resistance is a major problem in cancer therapeutics. Epithelial tumors commonly have mutations in the MAPK/Pi3K-AKT pathways, which leads to high-rate aerobic glycolysis. Here, we show how multikinase inhibitor antiangiogenics (TKIs) induce hypoxia correction in spontaneous breast and lung tumor models. When this happens, the tumors downregulate glycolysis and switch to long-term reliance on mitochondrial respiration. A transcriptomic, metabolomic, and phosphoproteomic study revealed that this metabolic switch is mediated by downregulation of HIF1α and AKT and upregulation of AMPK, allowing uptake and degradation of fatty acids and ketone bodies...
June 21, 2016: Cell Reports
https://www.readbyqxmd.com/read/27283493/different-metabolic-responses-to-pi3k-inhibition-in-nsclc-cells-harboring-wild-type-and-g12c-mutant-kras
#20
Elisa Caiola, Laura Brunelli, Mirko Marabese, Massimo Broggini, Monica Lupi, Roberta Pastorelli
KRAS mutations in non-small-cell lung cancer (NSCLC) patients are considered a negative predictive factor and indicate poor response to anticancer treatments. KRAS mutations lead to activation of the PI3K/akt/mTOR pathway, whose inhibition remains a challenging clinical target. Since the PI3K/akt/mTOR pathway and KRAS oncogene mutations all have roles in cancer cell metabolism, we investigated whether the activity of PI3K/akt/mTOR inhibitors (BEZ235 and BKM120) in cells harboring different KRAS status is related to their metabolic effect...
August 9, 2016: Oncotarget
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