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https://www.readbyqxmd.com/read/29445539/the-clinical-usefulness-of-a-self-administered-questionnaire-for-sleep-disordered-breathing-in-patients-with-neuromuscular-disease
#1
Cathy Zhang, Michelle Ramsay, Panagis Drakatos, Joerg Steier
Background: Patients with neuromuscular disease (NMD) are at risk of developing sleep-disordered breathing (SDB) with hypercapnic respiratory failure. We hypothesised that a self-administered questionnaire (SiNQ-5 scores) may be useful to assess patients who are established on treatment for NMD with SDB. Methods: Patients attending a tertiary referral centre filled in the SiNQ-5 (range 0-10 points, lower scores indicating fewer symptoms). The questionnaire contains five questions related to breathlessness, sleep and posture...
January 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29444773/lung-function-inflammation-and-endothelin-1-in-congenital-heart-disease-associated-pulmonary-arterial-hypertension
#2
Andrew Low, Sarah George, Luke Howard, Nicholas Bell, Ann Millar, Robert M R Tulloh
BACKGROUND: Breathlessness is the most common symptom in people with pulmonary arterial hypertension and congenital heart disease (CHD-APAH), previously thought to be caused by worsening PAH, but perhaps also by inflammation and abnormalities of lung function. We studied lung function and airway inflammation in patients with CHD-APAH and compared the results with controls. METHODS AND RESULTS: Sixty people were recruited into the study: 20 CHD-APAH, 20 CHD controls, and 20 healthy controls...
February 14, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29437948/the-great-breathlessness-of-cardiopulmonary-diseases
#3
EDITORIAL
Robert Naeije, Vitalie Faoro
No abstract text is available yet for this article.
February 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29436433/updates-in-palliative-care-recent-advancements-in-the-pharmacological-management-of-symptoms
#4
Angela Star, Jason W Boland
Symptom management is an important part of both palliative care and end-of-life care. This article will examine the recent research evidence about drugs commonly used for symptom management in adult patients receiving palliative care. In particular, the management of symptoms where recent palliative care-based evidence has changed recommended practice will be reviewed. This includes: breathlessness, delirium, nausea and vomiting in bowel obstruction, opioid-induced constipation and upper respiratory tract secretions...
February 2018: Clinical Medicine: Journal of the Royal College of Physicians of London
https://www.readbyqxmd.com/read/29424200/middle-lobe-syndrome-an-exceptional-presentation-of-concomitant-lepidic-adenocarcinoma-and-bronchial-anthracofibrosis
#5
Shekhar Kunal, Sudhir Jain, Ashok Shah
Lepidic adenocarcinoma previously known as bronchioloalveolar carcinoma (BAC) is a non-small cell lung cancer with an indolent presentation. Bronchial anthracofibrosis (BAF) is caused by long-standing exposure to biomass fuel smoke often in poorly ventilated kitchen. Middle lobe syndrome (MLS) due to BAF is not uncommon however, lepidic adenocarcinoma then known as BAC, presenting as MLS has been documented only once before in the Polish literature. A 68-year-old never-smoker female with biomass fuel smoke exposure presented with cough and breathlessness...
December 19, 2017: Monaldi Archives for Chest Disease, Archivio Monaldi Per le Malattie del Torace
https://www.readbyqxmd.com/read/29413500/evaluation-of-a-respiratory-symptom-diary-for-clinical-studies-of-idiopathic-pulmonary-fibrosis
#6
Elizabeth Dansie Bacci, Sean O'Quinn, Nancy Kline Leidy, Lindsey Murray, Margaret Vernon
BACKGROUND: There are no validated patient diaries for evaluating respiratory symptoms in idiopathic pulmonary fibrosis (IPF). PURPOSE: To evaluate the performance properties of the chronic obstructive pulmonary disease (COPD) Evaluating Respiratory Symptoms™ (E-RS™: COPD) measure in patients with IPF. METHODS: Concept elicitation and cognitive interviews were conducted with IPF patients to evaluate content validity, including comprehensiveness, relevance, and interpretability of E-RS™ items in this patient population...
January 2018: Respiratory Medicine
https://www.readbyqxmd.com/read/29411148/from-a-patient-advocate-s-perspective-does-cancer-immunotherapy-represent-a-paradigm-shift
#7
REVIEW
Debra L Madden
PURPOSE OF REVIEW: In 2016, the American Society of Clinical Oncology (ASCO) announced immunotherapy as the year's top cancer advance in its "Clinical Cancer Advances 2016: ASCO's Annual Report on Progress Against Cancer." Further, ASCO again named "Immunotherapy 2.0" as the 2017 advance of the year, emphasizing the recent, rapid pace of research into new agents that harness and enhance the innate abilities of the immune system to recognize and fight cancers-and stressing that such agents have extended the lives of many patients with late-stage cancers for which there have been few treatment options...
February 7, 2018: Current Oncology Reports
https://www.readbyqxmd.com/read/29406986/was-ugo-foscolo-1778-1827-affected-by-alpha-1-antitrypsin-deficiency
#8
A Perciaccante, C Negri, A Coralli, P Charlier, O Appenzeller, R Bianucci
Niccolò Ugo Foscolo (1778-1827), known as Ugo, is one of the masters of the Italian poetry. A writer and a revolutionary, he embraced the ideals of the French Revolution and took part in the stormy political discussions, which the fall of the Republic of Venice had provoked. Despite his poor health, Foscolo lived an adventurous life serving as a volunteer in the Guardia Nazionale and in the Napoleonic army. Following Napoleon's fall (1814), he went into voluntary exile in early 1815. He reached London in Sept...
February 2018: Medical Hypotheses
https://www.readbyqxmd.com/read/29386893/independent-determinants-of-disease-related-quality-of-life-in-copd-scope-for-nonpharmacologic-interventions
#9
Sarah B Brien, Beth Stuart, Andrew P Dickens, Tony Kendrick, Rachel E Jordan, Paymane Adab, Mike Thomas
Purpose: Quality-of-life (QoL) scores in chronic obstructive pulmonary disease (COPD) have a weak relationship with physiologic impairment. We investigated factors associated with poor QoL, focusing on psychological measures potentially amenable to intervention. Patients and methods: We utilized a pre-existing Birmingham (UK) COPD cohort to assess factors associated with QoL impairment (COPD Assessment Test [CAT] scores). Univariate and multivariate regression models were constructed from three categories of variables: demographic, lung function/COPD-related symptoms, and psychosocial/behavioral factors...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29386394/endocrine-regulation-of-airway-clearance-in-drosophila
#10
Do-Hyoung Kim, Young-Joon Kim, Michael E Adams
Fluid clearance from the respiratory system during developmental transitions is critically important for achieving optimal gas exchange in animals. During insect development from embryo to adult, airway clearance occurs episodically each time the molt is completed by performance of the ecdysis sequence, coordinated by a peptide-signaling cascade initiated by ecdysis-triggering hormone (ETH). We find that the neuropeptide Kinin (also known as Drosokinin or Leukokinin) is required for normal respiratory fluid clearance or "tracheal air-filling" in Drosophila larvae...
January 31, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29384901/acupuncture-for-idiopathic-pulmonary-fibrosis-protocol-for-a-systematic-review
#11
Yang Xie, Jia-Jia Wang, Gao-Yang Li, Xuan-Lin Li, Jian-Sheng Li
BACKGROUND: Patients with idiopathic pulmonary fibrosis (IPF) often suffer from progressive worsening of dyspnea and lung function. Although 2 drugs are now available for IPF treatment, many gaps are still to be filled. Evidences suggest that there may be some beneficial effect of acupuncture on pulmonary diseases. This review aims to systematically determine the efficacy and safety of acupuncture for treating IPF. METHODS: The following 8 databases will be searched from their inception to March 20, 2017: PubMed, Embase, Cochrane Central Register of Controlled Trials, Web of Science, Chinese Biomedical Literature Database, China National Knowledge Infrastructure, Chongqing VIP, and Wanfang Data...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29382628/using-the-inflammacheck-device-to-measure-the-level-of-exhaled-breath-condensate-hydrogen-peroxide-in-patients-with-asthma-and-chronic-obstructive-pulmonary-disease-the-exhale-pilot-study-protocol-for-a-cross-sectional-feasibility-study
#12
Daniel M Neville, Carole Fogg, Thomas P Brown, Thomas L Jones, Eleanor Lanning, Paul Bassett, Anoop J Chauhan
BACKGROUND: Asthma and Chronic Obstructive Pulmonary Disease (COPD) are common conditions that affect over 5 million people in the United Kingdom. These groups of patients suffer significantly from breathlessness and recurrent exacerbations that can be difficult to diagnose and go untreated. A common feature of COPD and asthma is airway inflammation that increases before and during exacerbations. Current methods of assessing airway inflammation can be invasive, difficult to perform, and are often inaccurate...
January 30, 2018: JMIR Research Protocols
https://www.readbyqxmd.com/read/29379233/radiological-spectrum-of-anthracofibrosis-a-series-of-40-patients-with-computed-tomography-bronchoscopy-and-biopsy
#13
Anandamoyee Dhar, Kunal Sikund, Ajal Lall, Bharat Aggarwal
Introduction: Anthracofibrosis is a lesser known clinical entity. Patients present with chronic symptoms of cough and breathlessness with a history of biofuel/wood fire smoke exposure. There are distinct computed tomography (CT) imaging features of anthracofibrosis that can differentiate it from more common conditions such as tuberculosis (TB) and bronchogenic carcinoma. Findings include multifocal noncontiguous stenosis of bronchial tree, calcified enlarged mediastinal or hilar nodes, and secondary lung parenchymal changes...
October 2017: Indian Journal of Radiology & Imaging
https://www.readbyqxmd.com/read/29373855/toward-better-management-for-asthma-from-smart-inhalers-to-injections-to-wearables-researchers-are-finding-new-ways-to-improve-asthma-treatment
#14
Wudan Yan
Although asthma has been around since Hippocrates' time, more people are being diagnosed with the disease than ever before. Over the last 20 years, the global burden of asthma has increased by almost 30%, as more than 235 million people-most of them children-cope with the breathlessness and wheezing characteristic of the disease. In particular, cases have spiked in China and India, where pollution is reported to sometimes be deadly. Researchers with the Health Effects Institute, a Boston-based nonprofit that studies the health effects of pollution, recently reported that air pollution in India and China alone contributed to more than half of the four million deaths worldwide due to air pollution in 2015...
January 2018: IEEE Pulse
https://www.readbyqxmd.com/read/29372080/troponin-testing-in-the-emergency-department-real-world-experience
#15
Mohammed Al-Maskari, Mahmoud Al-Makhdami, Hatim Al-Lawati, Hafidh Al-Hadi, Sunil K Nadar
Objectives: The aim of this study was to examine patterns of troponin testing in the emergency department of a large tertiary care hospital in Oman and to determine its effect on patient management, including length of hospital stay (LOS). Methods: This retrospective study analysed the medical records of all adult patients undergoing troponin testing in the emergency department of the Sultan Qaboos University Hospital, Muscat, Oman, during the month of July 2015...
November 2017: Sultan Qaboos University Medical Journal
https://www.readbyqxmd.com/read/29368107/predictors-of-severity-in-pediatric-scrub-typhus
#16
Dinesh Kumar Narayanasamy, Thirunavukkarasu Arun Babu, Vijayasankar Vijayadevagaran, Devi Kittu, Shanthi Ananthakrishnan
OBJECTIVE: To identify the factors that can predict the severity of scrub typhus in children. METHODS: This prospective study was conducted at a tertiary care teaching hospital between November 2014 to October 2016. All children <12y of age admitted with fever for more than 7d and positive IgM ELISA for scrub typhus were included in the study. These children were followed during the hospital course and their laboratory results, response to treatment and complications were documented...
January 24, 2018: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/29367364/unusual-case-of-hemidiaphragmatic-paralysis-secondary-to-cervical-herpes-zoster
#17
Muhammad Adnan Saleem, Zeeshan Mustafa, Noman Qayyum, Muhammad Badar Ganaie
Hemidiaphragmatic paralysis is usually caused by surgery, malignancy or trauma and rarely by viral infections. Herpes zoster (shingles) results in varied neurological complications, but peripheral motor involvement or diaphragmatic paralysis is rare. We report the case of an 87-year-old male who presented with worsening breathlessness soon after an episode of shingles, affecting his right neck and upper chest. He had no alarm symptoms, history of trauma or malignancy. Skin lesions resolved after a few weeks, but his breathing did not improve...
January 23, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29366911/coping-skills-practice-and-symptom-change-a-secondary-analysis-of-a-pilot-telephone-symptom-management-intervention-for-lung-cancer-patients-and-their-family-caregivers
#18
Joseph G Winger, Kevin L Rand, Nasser Hanna, Shadia I Jalal, Lawrence H Einhorn, Thomas J Birdas, DuyKhanh P Ceppa, Kenneth A Kesler, Victoria L Champion, Catherine E Mosher
CONTEXT: Little research has explored coping skills practice in relation to symptom outcomes in psychosocial interventions for cancer patients and their family caregivers. OBJECTIVES: To examine associations of coping skills practice to symptom change in a telephone symptom management (TSM) intervention delivered concurrently to lung cancer patients and their caregivers. METHODS: This study was a secondary analysis of a randomized pilot trial...
January 20, 2018: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/29332320/the-role-of-tiotropium-olodaterol-dual-bronchodilator-therapy-in-the-management-of-chronic-obstructive-pulmonary-disease
#19
REVIEW
David M G Halpin
Bronchodilator therapy is central to the management of chronic obstructive pulmonary disease and are recommended as the preferred treatment by the Global Obstructive Lung Disease Initiative (GOLD). Long acting anti-muscarinics (LAMA) and long acting β₂ agonists (LABA) are both more effective than regular short-acting drugs but many patients remain symptomatic despite monotherapy with these drugs. Combination therapy with LAMA and LABA increases the therapeutic benefit while minimizing dose-dependent side effects of long-acting bronchodilator therapy...
January 2018: Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/29326371/mycoplasma-pneumoniae-infection-presenting-as-stroke-and-meningoencephalitis-with-aortic-and-subclavian-aneurysms-without-pulmonary-involvement
#20
Pournamy Sarathchandran, Abubaker Al Madani, Ayman M Alboudi, Jihad Inshasi
A 39-year-old Philipino man presented with acute onset fever and headache. Neurological examination was normal except for neck stiffness. There was no history of chest pain, cough or breathlessness. Cerebrospinal fluid (CSF) showed a mild increase in protein with normal sugar and lymphocytic pleocytosis. CSF PCR for herpes simplex and varicella zoster virus was negative. He developed acute right haemiplegia a week after hospitalisation. MRI showed acute infarct in the left centrum semiovale. His angiogram showed aneurysm in the left subclavian artery and aortic arch...
January 11, 2018: BMJ Case Reports
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