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https://www.readbyqxmd.com/read/29691248/understanding-influences-on-the-uptake-of-pulmonary-rehabilitation-in-the-east-of-england-an-inclusive-design-mixed-methods-study-protocol
#1
Yuanyuan Liu, Terry Dickerson, Frances Early, Jonathan Fuld, P John Clarkson
INTRODUCTION: 1.2 million people in the UK have chronic obstructive pulmonary disease (COPD) that causes breathlessness, difficulty with daily activities, infections and hospitalisation. Pulmonary rehabilitation (PR), a programme of supervised exercise and education, is recommended for patients with COPD. However, only 1 in 10 of those who need it receive PR. Also, the UK National COPD Audit Programme concluded that the COPD treatment might not be accessible to people with disabilities...
April 24, 2018: BMJ Open
https://www.readbyqxmd.com/read/29690786/feasibility-study-to-assess-the-effect-of-a-brief-mindfulness-intervention-for-patients-with-chronic-obstructive-pulmonary-disease-a-randomized-controlled-trial
#2
Linda Perkins-Porras, Muhammad Riaz, Adeoba Okekunle, Svitlana Zhelezna, Indranil Chakravorty, Michael Ussher
Psychological distress is common among patients with chronic obstructive pulmonary disease (COPD). This study aimed to assess whether a 10-minute mindfulness intervention reduces distress and breathlessness, improves mood and increases mindfulness among hospital inpatients following acute exacerbation of COPD.Fifty patients were recruited following an acute admission. The immediate effects of a 10-minute mindfulness-based body scan were compared with a control intervention. Participants were randomized to receive either a mindfulness-based body scan ( n = 24) or a control condition ( n = 26) via a 10-minute audio recording...
January 1, 2018: Chronic Respiratory Disease
https://www.readbyqxmd.com/read/29688127/the-feasibility-of-a-randomised-controlled-trial-to-compare-the-cost-effectiveness-of-palliative-cardiology-or-usual-care-in-people-with-advanced-heart-failure-two-exploratory-prospective-cohorts
#3
Miriam J Johnson, Paula McSkimming, Alex McConnachie, Claudia Geue, Yvonne Millerick, Andrew Briggs, Karen Hogg
BACKGROUND: The effectiveness of cardiology-led palliative care is unknown; we have insufficient information to conduct a full trial. AIM: To assess the feasibility (recruitment/retention, data quality, variability/sample size estimation, safety) of a clinical trial of palliative cardiology effectiveness. DESIGN: Non-randomised feasibility. SETTING/PARTICIPANTS: Unmatched symptomatic heart failure patients on optimal cardiac treatment from (1) cardiology-led palliative service (caring together group) and (2) heart failure liaison service (usual care group)...
April 1, 2018: Palliative Medicine
https://www.readbyqxmd.com/read/29687352/an-autopsy-report-of-an-adenoid-cystic-carcinoma-arising-in-the-trachea
#4
Gargi Kapatia, Kirti Gupta, Oshan Shrestha, Anil Kumar, Ashish Bhalla
While adenoid cystic carcinoma is a common malignancy to arise within the salivary glands (21.9%) (Kokemueller et al. in Int J Oral Maxillofac Surg 33:25-31, 2004), it is seldom encountered as a tracheal mass and represents < 1% of all lung cancers. Tracheal tumors are an uncommon cause of dyspnoea due to their relatively rare occurrence (Baydur and Gottlieb in JAMA 234:829-831, 1975). They pose considerable diagnostic challenge clinically as their symptoms mimics more commoner ailments like asthma and chronic bronchitis...
April 23, 2018: Head and Neck Pathology
https://www.readbyqxmd.com/read/29684788/pneumonitis-secondary-to-alemtuzumab-in-a-patient-with-multiple-sclerosis-a-non-infectious-cause-of-breathlessness
#5
D Whiteside, S Barth, A Datta, S A Trip
The most common adverse events associated with the monoclonal antibody alemtuzumab are infusion associated reactions and secondary autoimmune disease. Respiratory complications are unusual following treatment with alemtuzumab, but can be precipitated by an infectious cause. We describe a case of a sub-acute steroid responsive non-infectious pneumonitis affecting a 51 year old woman, who presented one month after initiation of therapy for multiple sclerosis with alemtuzumab.
April 3, 2018: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29681814/non-gestational-choriocarcinoma-with-widespread-metastases-presenting-with-type-1-respiratory-failure-in-a-39-year-old-female-case-report-and-review-of-the-literature
#6
Louisa Stockton, Elizabeth Green, Baljeet Kaur, Emma De Winton
Introduction: Non-gestational choriocarcinoma (NGCC) is an extremely rare cancer. We report a case presenting in extremis. Case Report: A 39-year-old woman presented with type 1 respiratory failure with a 1-month history of breathlessness. Computed tomography (CT) revealed widespread metastatic disease involving the lungs, liver, pancreas, and breast. Serum β-human chorionic gonadotropin was markedly raised. Over 72 h, she deteriorated and was started on high-flow nasal cannula to facilitate discussions and for comfort...
January 2018: Case Reports in Oncology
https://www.readbyqxmd.com/read/29679597/management-of-dyspnea-in-the-terminally-ill
#7
REVIEW
Lara Pisani, Nicholas S Hill, Angela Maria Grazia Pacilli, Massimiliano Polastri, Stefano Nava
The genesis of dyspnea involves the activation of several mechanisms that are mediated and perceived depending on previous experiences, values, emotions and beliefs. Breathlessness may become unbearable, especially in terminally ill patients, whether afflicted by respiratory, cardiac or cancer-related disorders, due to a final stage of a chronic process, an acute event or both. Compared to pain, palliation of dyspnea has received relatively little attention in clinical practice and the medical literature. This is particularly true when the breathlessness is associated with acute respiratory failure since most of the studies on pharmacological and non-pharmacological treatments of respiratory distress have excluded such patients...
April 18, 2018: Chest
https://www.readbyqxmd.com/read/29678310/grossly-abnormal-ventilation-perfusion-spect-study-in-idiopathic-pulmonary-arterial-hypertension-without-thromboembolism
#8
Kenneth Chan, John G Coghlan, Margaret Hall, Jamanda Haddock, Alan Bates, Benjamin E Schreiber
Pulmonary hypertension is a serious condition with multiple underlying aetiologies which require different treatment strategies. We present a case of severe idiopathic pulmonary arterial hypertension in a 20-year-old patient with ongoing breathlessness. She was initially diagnosed with asthma and panic attacks in community care. As the symptoms became progressively worse, she was referred for pulmonary hypertension clinic assessment. Ventilation/perfusion single-photon emission computed tomography (V/Q SPECT) showed grossly abnormal perfusion defects which were mismatched to the ventilation scan, suggestive of chronic thromboembolic disease...
January 31, 2018: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/29677408/use-of-oxygen-at-the-end-of-life-attitudes-beliefs-and-practices-in-wisconsin
#9
Lisa Quinn-Lee, Jeanne Weggel, Susan D Moch
INTRODUCTION: Oxygen therapy for the management of breathlessness remains controversial and little information is available regarding the practice of using oxygen at end of life. Oxygen use in end-of-life care is increasingly being questioned, while the use of oxygen for routine "comfort care" at end of life continues. OBJECTIVE: The purpose of this study was to investigate the use of oxygen at the end of life and to understand its role in contemporary palliative care practice...
March 2018: WMJ: Official Publication of the State Medical Society of Wisconsin
https://www.readbyqxmd.com/read/29676635/effects-of-household-air-pollution-in-malawi-and-human-immunodeficiency-virus-status-on-respiratory-symptoms-and-inflammation-injury-and-repair-markers
#10
Charles Kim, Hannah Jary, Kevin Mortimer, Kelly S Schweitzer, Doug Curran-Everett, Stephen Gordon, Irina Petrache
RATIONALE: Household air pollution (HAP) and human immunodeficiency virus (HIV) are associated with increased risk for chronic obstructive pulmonary disease. Both HAP and HIV are widespread in Sub-Saharan Africa, including Malawi, where HIV has 10.6% prevalence in patients 15-49 years old. OBJECTIVES: We hypothesized that HIV infection (HIV+ ) and habitual exposure to HAP (HAP+ ) synergize to cause systemic inflammation and vascular injury, which may herald early onset of chronic respiratory diseases...
April 2018: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/29670345/practical-considerations-when-prescribing-a-long-acting-muscarinic-antagonist-for-patients-with-copd
#11
REVIEW
Anthony D D'Urzo, Peter Kardos, Russell Wiseman
COPD is characterized by persistent airflow limitation, progressive breathlessness, cough, and sputum production. Long-acting muscarinic antagonists (LAMAs) are one of the recommended first-choice therapeutic options for patients with COPD, and several new agents have been developed in recent years. A literature search identified 14 published randomized, placebo-controlled studies of the efficacy and safety of LAMAs in patients with COPD, with improvements seen in lung function, exacerbations, breathlessness, and health status...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29669719/breathless-athlete-exercise-induced-laryngeal-obstruction
#12
Steffan Arthur Griffin, Emil S Walsted, James H Hull
No abstract text is available yet for this article.
April 18, 2018: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/29667212/breathlessness-amplifies-amygdala-responses-during-affective-processing
#13
M Cornelia Stoeckel, Roland W Esser, Matthias Gamer, Andreas von Leupoldt
Breathlessness is an aversive symptom in many prevalent somatic and psychiatric diseases and is usually experienced as highly threatening. It is strongly associated with negative affect, but the underlying neural processes remain poorly understood. Therefore, using fMRI, the present study examined the effects of breathlessness on the neural processing of affective visual stimuli within candidate brain areas including the amygdala, insula, and anterior cingulate cortex (ACC). During scanning, 42 healthy volunteers, mean (SD) age: 29...
April 17, 2018: Psychophysiology
https://www.readbyqxmd.com/read/29666219/symptoms-at-lung-cancer-diagnosis-are-associated-with-major-differences-in-prognosis
#14
Victoria L Athey, Stephen J Walters, Trevor K Rogers
We report a cohort study of survival of patients with lung cancer presenting to a single multidisciplinary team between 1997 and 2011, according to symptoms at presentation. The overall median survival of the 3800 lung cases was 183 days (95% CI 171 to 195). There was a statistically significant difference in survival between the 12 symptom groups identified both without and with adjustment for the prognostic variables of age, gender and histology (P<0.001). Compared with the cough-alone symptom group, the risks of dying or HRs were significantly higher for the groups presenting with breathlessness (HR 1...
April 17, 2018: Thorax
https://www.readbyqxmd.com/read/29661795/machine-learning-analysis-of-left-ventricular-function-to-characterize-heart-failure-with-preserved-ejection-fraction
#15
Sergio Sanchez-Martinez, Nicolas Duchateau, Tamas Erdei, Gabor Kunszt, Svend Aakhus, Anna Degiovanni, Paolo Marino, Erberto Carluccio, Gemma Piella, Alan G Fraser, Bart H Bijnens
BACKGROUND: Current diagnosis of heart failure with preserved ejection fraction (HFpEF) is suboptimal. We tested the hypothesis that comprehensive machine learning (ML) of left ventricular function at rest and exercise objectively captures differences between HFpEF and healthy subjects. METHODS AND RESULTS: One hundred fifty-six subjects aged >60 years (72 HFpEF+33 healthy for the initial analyses; 24 hypertensive+27 breathless for independent evaluation) underwent stress echocardiography, in the MEDIA study (Metabolic Road to Diastolic Heart Failure)...
April 2018: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29661041/prospective-risk-of-osteoporotic-fractures-in-patients-with-advanced-chronic-obstructive-pulmonary-disease
#16
Ayushman Gupta, Neil J Greening, Rachael A Evans, Abigail Samuels, Nicole Toms, Michael C Steiner
Despite the high prevalence of osteoporosis in chronic obstructive pulmonary disease (COPD) patients, the fracture risk prediction tools are not routinely undertaken in the management of COPD. We quantified fracture risk using a validated risk prediction tool (Fracture Risk Assessment (FRAX®)) and determined potential bone-protection treatment needs in patients with advanced COPD. The 10-year probability of major osteoporotic or hip fracture was calculated using the FRAX tool in a cohort of patients attending a hospital complex COPD service...
January 1, 2018: Chronic Respiratory Disease
https://www.readbyqxmd.com/read/29656713/symptom-management-nutrition-and-hydration-at-end-of-life-a-qualitative-exploration-of-patients-carers-and-health-professionals-experiences-and-further-research-questions
#17
Jessica Baillie, Despina Anagnostou, Stephanie Sivell, Jordan Van Godwin, Anthony Byrne, Annmarie Nelson
BACKGROUND: Symptom management is an essential aspect of palliative and end-of-life care, but evidence suggests that patients' symptoms may not always be relieved, causing significant harm to patients and magnifying their relatives' distress. A growing body of evidence focuses on symptom management at the end-of-life, but research funding for palliative care remains disproportionately low. It is therefore crucial that research funding is targeted at areas of importance to patients and relatives...
April 16, 2018: BMC Palliative Care
https://www.readbyqxmd.com/read/29629620/differential-training-loads-and-individual-fitness-responses-to-pre-season-in-professional-rugby-union-players
#18
Shaun J McLaren, Andrew Smith, Jonathan D Bartlett, Iain R Spears, Matthew Weston
We aimed to compare differentiated training loads (TL) between fitness responders and non-responders to an eight-week pre-season training period in a squad of thirty-five professional rugby union players. Differential TL were calculated by multiplying player's perceptions of breathlessness (sRPE-B) and leg muscle exertion (sRPE-L) with training duration for each completed session. Performance-based fitness measures included the Yo-Yo Intermittent Recovery Test Level 1 (YYIRTL1), 10-, 20-, and 30-m linear sprint times, countermovement jump height (CMJ) and predicted one-repetition maximum back squat (P1RM Squat)...
April 9, 2018: Journal of Sports Sciences
https://www.readbyqxmd.com/read/29629402/the-short-term-impact-of-symptom-defined-copd-exacerbation-recovery-on-health-status-and-lung-function
#19
Lindsey T Murray, Nancy K Leidy
Background: This study examined the short-term effects of symptom-defined exacerbation recovery on health status and pulmonary function in moderate to severe chronic obstructive pulmonary disease (COPD) patients. Methods: Secondary analyses of pooled data from two 12-week Phase II international, randomized controlled trials using the EXA cerbations of C hronic Pulmonary Disease T ool (EXACT) to identify symptom-defined exacerbations were conducted. Recovery was categorized as recovered, unrecovered (persistent worsening), or censored...
January 24, 2018: Chronic Obstructive Pulmonary Diseases: Journal of the COPD Foundation
https://www.readbyqxmd.com/read/29628971/establishment-of-a-chronic-obstructive-pulmonary-disease-mouse-model-based-on-the-elapsed-time-after-lps-intranasal-instillation
#20
Soon-Young Lee, Jin-Ho Cho, Seung Sik Cho, Chun-Sik Bae, Gye-Yeop Kim, Dae-Hun Park
Chronic obstructive pulmonary disease (COPD) was the 3rd leading cause of death in 2012 worldwide. It is particularly severe in the elderly, who are at risk of death by coughing, mucous hypersecretion, and finally breathlessness. Recently, anti-COPD drug development has increased, and many animal screening systems have been studied. Tobacco smoke animal models are the best known animal screening system, but have several preparation requirements, such as a tobacco smoke generator and a separate facility to prevent smoke release...
March 2018: Laboratory Animal Research
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