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Lipoic acid

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https://www.readbyqxmd.com/read/29339506/development-and-retention-of-a-primordial-moonlighting-pathway-of-protein-modification-in-the-absence-of-selection-presents-a-puzzle
#1
Xinyun Cao, Yaoqin Hong, Lei Zhu, Yuanyuan Hu, John E Cronan
Lipoic acid is synthesized by a remarkably atypical pathway in which the cofactor is assembled on its cognate proteins. An octanoyl moiety diverted from fatty acid synthesis is covalently attached to the acceptor protein, and sulfur insertion at carbons 6 and 8 of the octanoyl moiety form the lipoyl cofactor. Covalent attachment of this cofactor is required for function of several central metabolism enzymes, including the glycine cleavage H protein (GcvH). In Bacillus subtilis, GcvH is the sole substrate for lipoate assembly...
January 16, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29337238/advantages-of-the-alpha-lipoic-acid-association-with-chlorpromazine-in-a-model-of-schizophrenia-induced-by-ketamine-in-rats-behavioral-and-oxidative-stress-evidences
#2
Luis Rafael Leite Sampaio, Francisco Maurício Sales Cysne Filho, Jamily Cunha de Almeida, Danilo Dos Santos Diniz, Cláudio Felipe Vasconcelos Patrocínio, Caren Nádia Soares de Sousa, Manoel Cláudio Azevedo Patrocínio, Danielle S Macêdo, Silvânia Maria Mendes Vasconcelos
Schizophrenia is a chronic mental disorder reported to compromise about 1% of the world's population. Although its pathophysiological process is not completely elucidated, evidence showing the presence of an oxidative imbalance has been increasingly highlighted in the literature. Thus, the use of antioxidant substances may be of importance for schizophrenia treatment. The objective of this study was to evaluate the behavioral and oxidative alterations by the combination of chlorpromazine (CP) and alpha-lipoic acid (ALA), a potent antioxidant, in the ketamine (KET) model of schizophrenia in rats...
January 11, 2018: Neuroscience
https://www.readbyqxmd.com/read/29336543/histone-deacetylase-11-is-a-fatty-acid-deacylase
#3
Zsofia Kutil, Zora Novakova, Marat Meleshin, Jana Mikesova, Mike Schutkowski, Cyril Barinka
Histone deacetylase 11 (HDAC11) is a sole member of the class IV HDAC subfamily with negligible intrinsic deacetylation activity. Here we report in vitro profiling of HDAC11 deacylase activities, and our data unequivocally show that the enzyme efficiently removes acyl moieties spanning 8-18 carbons from the side chain nitrogen of the lysine residue of a peptidic substrate. Additionally, N-linked lipoic acid and biotin are removed by the enzyme, although with lower efficacy. Catalytic efficiencies toward dodecanoylated and myristoylated peptides were 77,700 M-1s-1 and 149,000 M-1s-1, respectively, making HDAC11 the most proficient fatty acid deacylase of the HDAC family...
January 16, 2018: ACS Chemical Biology
https://www.readbyqxmd.com/read/29335837/backbone-chemical-shift-assignments-of-the-glycine-cleavage-complex-h-protein-of-escherichia-coli
#4
Usha Yadav, Monica Sundd
Glycine cleavage complex H protein (GcvH) is one of the four components that form the glycine cleavage complex (GCS), essential for the synthesis of C1 (one-carbon units) for cell metabolism, by the oxidative cleavage of glycine. The activity of this complex is induced in the presence of exogenous glycine, and is repressed by purines. GCS, in cooperation with GCA (serine hydroxymethyltransferase) regulates the endogenous levels of glycine and C1 units in the cell. GcvH, the lipoamide containing component of the complex, plays an indispensable role in this reaction, as its prosthetic group shuttles between the active site of the three other components of the GCS complex sequentially...
January 15, 2018: Biomolecular NMR Assignments
https://www.readbyqxmd.com/read/29334926/-r-%C3%AE-lipoic-acid-inhibits-fructose-induced-myoglobin-fructation-and-the-formation-of-advanced-glycation-end-products-ages-in-vitro
#5
Hardik Ghelani, Valentina Razmovski-Naumovski, Rajeswara Rao Pragada, Srinivas Nammi
BACKGROUND: Fructose-mediated protein glycation (fructation) has been linked to an increase in diabetic and cardiovascular complications due to over consumption of high-fructose containing diets in recent times. The objective of the present study is to evaluate the protective effect of (R)-α-lipoic acid (ALA) against fructose-induced myoglobin fructation and the formation of advanced glycation end products (AGEs) in vitro. METHODS: The anti-glycation activity of ALA was determined using the formation of AGEs fluorescence intensity, iron released from the heme moiety of myoglobin and the level of fructosamine...
January 15, 2018: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29329865/in-vitro-evaluation-of-dietary-compounds-to-reduce-mercury-bioavailability
#6
Carlos Jadán-Piedra, Dinoraz Vélez, Vicenta Devesa
Mercury in foods, in inorganic form [Hg(II)] or as methylmercury (CH3Hg), can have adverse effects. Its elimination from foods is not technologically viable. To reduce human exposure, possible alternatives might be based on reducing its intestinal absorption. This study evaluates the ability of 23 dietary components to reduce the amount of mercury that is absorbed and reaches the bloodstream (bioavailability). We determined their effect on uptake of mercury in Caco-2 cells, a model of intestinal epithelium, exposed to Hg(II) and CH3Hg standards and to swordfish bioaccessible fractions...
May 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29329705/low-cost-and-disposable-sensors-for-the-simultaneous-determination-of-coenzyme-q10-and-%C3%AE-lipoic-acid-using-manganese-iv-oxide-modified-screen-printed-graphene-electrodes
#7
Kanokwan Charoenkitamorn, Sudkate Chaiyo, Orawon Chailapakul, Weena Siangproh
In this work, for the first time, manganese (IV) oxide-modified screen-printed graphene electrodes (MnO2/SPGEs) were developed for the simultaneous electrochemical detection of coenzyme Q10 (CoQ10) and α-lipoic acid (ALA). This sensor exhibits attractive benefits such as simplicity, low production costs, and disposability. Cyclic voltammetry (CV) was used to characterize the electrochemical behavior of the analyte and investigate the capacitance and electroactive surface area of the unmodified and modified electrode surfaces...
April 3, 2018: Analytica Chimica Acta
https://www.readbyqxmd.com/read/29316094/integrated-multifunctional-micelles-co-self-assembled-from-polypeptides-conjugated-with-natural-ferulic-acid-and-lipoic-acid-for-efficient-and-bioresponsive-doxorubicin-delivery
#8
Zhiyuan Zhong, Tao Chen, Min Qiu, Jian Zhang, Huanli Sun, Chao Deng
How to develop safe, easily accessible, and multifunctional nanocarriers is a big theme for nanomedicine research. Here, integrated multifunctional micelles (IMM) were developed by co-self-assembly of poly(ethylene glycol)-b-poly(L-lysine) derivatives with natural ferulic acid or lipoic acid. FA confers IMM with intrinsic antitumor activity, improved loading of doxorubicin (DOX) via π-π stacking, and reduced DOX cardiotoxicity. LA provides IMM with reversible crosslinking property which leads to a high colloidal stability with inhibited drug leakage and triggered intracellular DOX release...
January 9, 2018: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/29314036/multilayer-emulsions-as-a-strategy-for-linseed-oil-and-alpha-lipoic-acid-micro-encapsulation-study-on-preparation-and-in-vitro-characterization
#9
Juan Huang, Qiang Wang, Tong Li, Nan Xia, Qiang Xia
BACKGROUND: Linseed oil and alpha-lipoic acid are bioactive ingredients, which play an important role in human's nutrition and health. However, their application in functional foods is limited because of their instabilities and poor solubilities in hydrophilic matrices. Multilayer emulsions are particularly useful to protect encapsulated bioactive ingredients. The aim of this study was to fabricate multilayer emulsions by high pressure homogenization method to encapsulate linseed oil and alpha-lipoic acid simultaneously...
January 4, 2018: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/29310488/the-effects-of-lipoic-acid-and-methylprednisolone-on-nerve-healing-in-rats-with-facial-paralysis
#10
Emrah Tekdemir, Arzu Tatlipinar, Dilek Özbeyli, Özge Tekdemir, Emrah Kınal
OBJECTIVE: To investigate the effects of lipoic acid and methylprednisolone on nerve healing in rats with traumatic facial paralysis. MATERIALS AND METHODS: The rats were randomly divided into four groups, with six rats in the control group and eight each in the remaining three groups. The buccal branch of the facial nerve in all groups except the control group was traumatized by a vascular clamp for 40 minutes. Group 1 was given lipoic acid (LA), Group 2 was given methylprednisolone (MP), and Group 3 was given lipoic acid and methylprednisolone (LA + MP) for one week...
January 8, 2018: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/29306401/effects-of-lipoic-acid-on-migration-of-human-b-cells-and-monocyte-enriched-peripheral-blood-mononuclear-cells-in-relapsing-remitting-multiple-sclerosis
#11
Joshua D George, Edward Kim, Rebecca Spain, Dennis Bourdette, Sonemany Salinthone
Multiple sclerosis (MS) is a disease of the central nervous system characterized by inflammation and demyelination resulting in clinical disability. The rodent MS model suggests that infiltration of monocytes and B cells contributes to disease pathogenesis. Here, we compared the migratory capacity of human monocytes and B cells from healthy control (HC) and relapsing-remitting MS (RRMS) subjects, with or without lipoic acid (LA) treatment. Basal migration of monocyte-enriched PBMCs from RRMS subjects is significantly higher than HC PBMCs...
February 15, 2018: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/29300330/alpha-lipoic-acid-a-therapeutic-strategy-that-tend-to-limit-the-action-of-free-radicals-in-transplantation
#12
REVIEW
Nella Ambrosi, Diego Guerrieri, Fiorella Caro, Francisco Sanchez, Geraldine Haeublein, Domingo Casadei, Claudio Incardona, Eduardo Chuluyan
Organ replacement is an option to mitigate irreversible organ damage. This procedure has achieved a considerable degree of acceptance. However, several factors significantly limit its effectiveness. Among them, the initial inflammatory graft reaction due to ischemia-reperfusion injury (IRI) has a fundamental influence on the short and long term organ function. The reactive oxygen species (ROS) produced during the IRI actively participates in these adverse events. Therapeutic strategies that tend to limit the action of free radicals could result in beneficial effects in transplantation outcome...
January 4, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29260853/liquid-chromatography-separation-and-mass-spectrometry-detection-of-silver-lipoate-ag29-la-12-nanoclusters-evidence-of-isomerism-in-the-solution-phase
#13
David M Black, Geronimo Robles, Priscilla Lopez, Stephan B H Bach, Marcos M Alvarez, Robert L Whetten
Evidence for the existence of condensed phase isomers of silver-lipoate clusters, Ag29(LA)12, where LA = (R) - α lipoic acid, was obtained by reversed-phase ion-pair liquid chromatography with inline UV-vis and ESI-MS detection. All components of a raw mixture were separated according to surface chemistry and increasing size via reversed-phase gradient HPLC methods and identified by their corresponding m/z ratio by electrospray ionization (ESI) in the negative ionization mode. Aqueous and methanol mobile-phase mixtures, each containing 400 mM hexafluoroisopropanol (HFIP) - 15 mM triethylamine (TEA), were employed to facilitate interaction between the clusters and stationary phase via formation of ion-pairs...
December 20, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29258346/the-long-term-survival-of-a-patient-with-stage-iv-renal-cell-carcinoma-following-an-integrative-treatment-approach-including-the-intravenous-%C3%AE-lipoic-acid-low-dose-naltrexone-protocol
#14
Burton M Berkson, Francisco Calvo Riera
In this case report, we describe the treatment of a 64-year-old male patient diagnosed with metastatic renal cell carcinoma (RCC) in June of 2008. In spite of a left nephrectomy and the standard oncological protocols, the patient developed a solitary left lung metastasis that continued to grow. He was informed that given his diagnosis and poor response to conventional therapy, any further treatment would, at best, be palliative. The patient arrived at the Integrative Medical Center of New Mexico in August of 2010...
December 1, 2017: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/29249928/the-antioxidant-cofactor-alpha-lipoic-acid-may-control-endogenous-formaldehyde-metabolism-in-mammals
#15
Anastasia V Shindyapina, Tatiana V Komarova, Ekaterina V Sheshukova, Natalia M Ershova, Vadim N Tashlitsky, Alexander V Kurkin, Ildar R Yusupov, Garik V Mkrtchyan, Murat Y Shagidulin, Yuri L Dorokhov
The healthy human body contains small amounts of metabolic formaldehyde (FA) that mainly results from methanol oxidation by pectin methylesterase, which is active in a vegetable diet and in the gastrointestinal microbiome. With age, the ability to maintain a low level of FA decreases, which increases the risk of Alzheimer's disease and dementia. It has been shown that 1,2-dithiolane-3-pentanoic acid or alpha lipoic acid (ALA), a naturally occurring dithiol and antioxidant cofactor of mitochondrial α-ketoacid dehydrogenases, increases glutathione (GSH) content and FA metabolism by mitochondrial aldehyde dehydrogenase 2 (ALDH2) thus manifests a therapeutic potential beyond its antioxidant property...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29248558/curcumin-lipoic-acid-conjugate-as-a-promising-anticancer-agent-on-the-surface-of-gold%C3%A2-iron-oxide-nanocomposites-a-ph-sensitive-targeted-drug-delivery-system-for-brain-cancer-theranostics
#16
Milad Ghorbani, Bahareh Bigdeli, Leili Jalili-Baleh, Hadi Baharifar, Mohammad Akrami, Sadegh Dehghani, Bahram Goliaei, Amir Amani, Alireza Lotfabadi, Hamid Rashedi, Ismaeil Haririan, Nader Riyahi Alam, Morteza Pirali Hamedani, Mehdi Khoobi
Brain tumor is a lethal, fast growing cancer and a difficult case for treatment. Receptor-mediated endocytosis has been recognized as one of the most effective methods for drug delivery to brain tissue by overcoming obstacles associated with conventional therapeutics. In this work, a targeted theranostic drug delivery system (DDS) was prepared based on gold‑iron oxide nanocomposites (Fe3O4@Au NCs). Lipoic acid-curcumin (LA-CUR) was synthesized and introduced as a novel anticancer drug, and glutathione (GSH) was exploited as the targeting ligand...
December 14, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29246754/thioctic-acid-in-oral-submucous-fibrosis-india-s-disease-a-better-tomorrow
#17
Bhandarkar Gowri Pandarinath, V Shetty Kushal, Kulkarni Arati
Oral submucous fibrosis(OSMF), because of its common occurrence in Indian population is known as India's disease. Regardless of diagnostic and therapeutic developments, oral potentially malignant disorders(PMD) and cancers are disseminating at a distressing rate. There is this prerequisite for unrelenting determination to find out apt treatment options so that malignant transformation may be prevented and more so the prevailing morbidity and mortality. Considering the frequency with which oral submucous fibrosis undergoes malignant transformation with free radicals playing a major part, the role of antioxidants in general and thioctic acid also known as alpha lipoic acid(ALA) in particular need to be studied in these individuals...
December 12, 2017: Journal of Stomatology, Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29246281/%C3%AE-lipoic-acid-ameliorated-oxidative-stress-induced-by-perilla-oil-but-the-combination-of-these-dietary-factors-was-ineffective-to-cause-marked-deceases-in-serum-lipid-levels-in-rats
#18
Takashi Ide, Ai Tanaka
Dietary perilla oil rich in α-linolenic acid and α-lipoic acid lowers the serum lipid level through changes in hepatic fatty acid metabolism. We therefore hypothesized that the combination of these dietary factors may ameliorate lipid metabolism more than the factors individually. Moreover, α-lipoic acid exerts strong anti-oxidative activity. Hence, we also hypothesized that α-lipoic acid may attenuate perilla oil-mediated oxidative stress. We therefore studied the combined effects of perilla oil and α-lipoic acid on lipid metabolism and parameters of oxidative stress...
December 2017: Nutrition Research
https://www.readbyqxmd.com/read/29245965/the-aldehyde-group-of-gossypol-induces-mitochondrial-apoptosis-via-ros-sirt1-p53-puma-pathway-in-male-germline-stem-cell
#19
Xin He, Chongyang Wu, Yanhua Cui, Haijing Zhu, Zhiming Gao, Bo Li, Jinlian Hua, Baoyu Zhao
As a widely grown economic crop, cotton is the major oil and protein resource for human and livestock. But the highly toxic of gossypol in cottonseed severely restricts its effective utilization, consequently creating huge resource waste. Previous studies have shown the male germline stem cells were the most vulnerable cells in gossypol damages, but the mechanism was still unclear. We found gossypol induced cell viability decline resulted from apoptosis. And the increase of Caspase-9 activity in gossypol treatment hinted the mitochondrial apoptosis...
November 21, 2017: Oncotarget
https://www.readbyqxmd.com/read/29240231/the-issue-of-hplc-determination-of-endogenous-lipoic-acid-in-human-plasma
#20
Soňa Sechovcová, Pavla Královcová, Roman Kanďár, Karel Ventura
Lipoic acid (LA) is used extensively as a therapeutic agent for the treatment of various diseases. Many methods have been reported for the determination of LA plasma levels and its metabolites after its supplementation, but available information concerning endogenous plasma levels is still rare. Studies, which directly focused on determining the endogenous plasma levels, provided highly controversial results, less than 4.9 nmol/L or 143.7 - 197.0 nmol/L. The main aim of this study was to verify the levels of free LA in the plasma of 40 individuals (17 women, 23 men)...
December 14, 2017: Biomedical Chromatography: BMC
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