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Lipoic acid

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https://www.readbyqxmd.com/read/28641283/-healing-of-amyotrophic-lateral-sclerosis-a-case-report
#1
Inge Mangelsdorf, Harald Walach, Joachim Mutter
BACKGROUND: Amyotrophic lateral sclerosis (ALS) is a devastating disease leading to death within 3-5 years in most cases. New approaches to treating this disease are needed. Here, we report a successful therapy. CASE REPORT: In a 49-year-old male patient suffering from muscle weakness and fasciculations, progressive muscular atrophy, a variant of ALS, was diagnosed after extensive examinations ruling out other diseases. Due to supposed mercury exposure from residual amalgam, the patient's teeth were restored...
2017: Complementary Medicine Research
https://www.readbyqxmd.com/read/28638031/-anxiolytic-and-antidepressant-effects-of-emoxipine-reamberin-and-mexidol-in-experimental-diabetes-mellitus
#2
I A Volchegorskii, I Yu Miroshnichenko, L M Rassokhina, R M Faizullin, K E Pryakhina
AIM: To perform a comparative study of anxiolytic and antidepressant effects of derivatives of 3-oxypyridine and succinic acid (emoxipine, reamberin and mexidol) in experimental diabetes mellitus. MATERIAL AND METHODS: An effect of emoxipine, reamberin and mexidol on manifestations of anxiety in 'elevated plus maze' (EPM) and duration of 'desperate behavior' (DB) in Porsolt test in rats with alloxan diabetes during medication course was studied. Alpha-lipoic (thioctic) acid (α-LA) was used as a reference drug...
2017: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/28636787/a-co-drug-conjugate-of-naringenin-and-lipoic-acid-mediates-neuroprotection-in-a-rat-model-of-oxidative-stress
#3
Tarek M Saleh, Monique C Saleh, Barry J Connell, Yang-Heon Song
Using our in vitro and in vivo models of oxidative stress, the current study was designed to determine the neuroprotective potential of naringenin, alone or in combination with lipoic acid. In our mixed neuronal culture exposed to hypoxia and subsequent reoxygenation, naringenin was shown to provide significant neuroprotection against cell death at a concentration of 2.5 μM. Lipoic acid (LA) did not produce neuroprotection at any concentration tested (0.25 to 100 μM). In contrast, when naringenin was covalently combined with LA, producing a novel compound named "VANL-100", significant neuroprotection was observed at a concentration as low as 2 x 10(-2) μM (100-fold more potent)...
June 21, 2017: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/28629898/alpha-lipoic-acid-supplement-in-obesity-treatment-a-systematic-review-and-meta-analysis-of-clinical-trials
#4
REVIEW
Nazli Namazi, Bagher Larijani, Leila Azadbakht
BACKGROUND & AIMS: Previous studies have supported positive roles of antioxidant supplements on weight-loss. One antioxidant supplement is Alpha-lipoic acid. However, recommending ALA as an anti-obesity supplement remains controversial. Accordingly, the purpose of the present study was to perform a meta-analysis on the effects of ALA supplement on anthropometric indices among adult subjects. METHODS: We searched five electronic databases till September 2016. Placebo-controlled clinical trials were included...
June 8, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28629046/lipoic-acid-functionalized-sio2-ag-nanoparticles-synthesis-characterization-and-evaluation-of-biological-activity
#5
Madalina Tudose, Daniela Cristina Culita, Adina Magdalena Musuc, Simona Somacescu, Cornel Ghica, Mariana Carmen Chifiriuc, Coralia Bleotu
A novel nanocomposite was obtained through the covalent immobilization of lipoic acid on the surface of silver nanoparticles-decorated silica nanoparticles (SiO2@Ag). The hybrid organic - inorganic material obtained was characterized by Fourier transform infrared spectroscopy, thermal analysis, scanning and transmision electron microscopy, X-ray photoelectron spectroscopy and UV-Visible spectroscopy. Its antioxidant, cytotoxic, antimicrobial activity and influence on mammalian cells cycle were evaluated. The results of this study have shown that the functionalization of SiO2@Ag with lipoic acid resulted in a composite with increased specificity of interaction with different mammalian cell lines and antioxidant activity, but with decreased cytotoxicity and antimicrobial properties...
October 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28628643/mis-targeting-of-the-mitochondrial-protein-lipt2-leads-to-apoptotic-cell-death
#6
Emanuele Bernardinelli, Roberta Costa, Giada Scantamburlo, Janet To, Rossana Morabito, Charity Nofziger, Carolina Doerrier, Gerhard Krumschnabel, Markus Paulmichl, Silvia Dossena
Lipoyl(Octanoyl) Transferase 2 (LIPT2) is a protein involved in the post-translational modification of key energy metabolism enzymes in humans. Defects of lipoic acid synthesis and transfer start to emerge as causes of fatal or severe early-onset disease. We show that the first 31 amino acids of the N-terminus of LIPT2 represent a mitochondrial targeting sequence and inhibition of the transit of LIPT2 to the mitochondrion results in apoptotic cell death associated with activation of the apoptotic volume decrease (AVD) current in normotonic conditions, as well as over-activation of the swelling-activated chloride current (IClswell), mitochondrial membrane potential collapse, caspase-3 cleavage and nuclear DNA fragmentation...
2017: PloS One
https://www.readbyqxmd.com/read/28619361/%C3%AE-lipoic-acid-ameliorates-n-3-highly-unsaturated-fatty-acids-induced-lipid-peroxidation-via-regulating-antioxidant-defenses-in-grass-carp-ctenopharyngodon-idellus
#7
Xiao-Chen Shi, Ai Jin, Jian Sun, Zhou Yang, Jing-Jing Tian, Hong Ji, Hai-Bo Yu, Yang Li, Ji-Shu Zhou, Zhen-Yu Du, Li-Qiao Chen
This study evaluated the protective effect of α-lipoic acid (LA) on n-3 highly unsaturated fatty acids (HUFAs)-induced lipid peroxidation in grass carp. The result indicated that diets with n-3 HUFAs increased the production of malondialdehyde (MDA) (P < 0.05), thereby inducing lipid peroxidation in liver and muscle of grass carp. Meanwhile, compared with control group, the hepatosomatic index (HSI) and kidney index (KI) of grass carp were markedly increased in n-3 HUFAs-only group. However, diets with LA remarkably inhibited the n-3 HUFAs-induced increase of HSI, KI, and MDA level in serum, liver and muscle (P < 0...
June 13, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28617535/research-on-the-protective-effects-of-antioxidants-on-metabolic-syndrome-induced-by-thyroid-dysfunction
#8
Y Chen, Z Zhou, X-X Li, T Wang
OBJECTIVE: This paper researches on the protective effects of antioxidants on metabolic syndrome induced by thyroid dysfunction. While the role of Lipoic acid (LA), Resveratrol (R) and Quercetin (Q) are recognized, the mechanisms for their ameliorative effects are partially understood. Therefore, the objective of this study was to determine the prevalence of MS among university workers and to examine the relationship with thyroid function and mechanisms for protective effects of LA, Resveratrol and Quercetin on the heart, kidneys and lungs...
May 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28611356/the-osteogenesis-promoting-effects-of-alpha-lipoic-acid-against-glucocorticoid-induced-osteoporosis-through-the-nox4-nf-kappab-jnk-and-pi3k-akt-pathways
#9
Shi-Yu Lu, Chang-Yuan Wang, Yue Jin, Qiang Meng, Qi Liu, Zhi-Hao Liu, Ke-Xin Liu, Hui-Jun Sun, Mo-Zhen Liu
Recently, accumulating evidence has indicated that glucocorticoid-induced osteoporosis (GIOP) is closely related to oxidative stress and apoptosis. Alpha-lipoic acid (LA), a naturally endogenous anti-oxidant, possesses anti-oxidative and anti-apoptosis activities, implicating LA as a therapeutic agent for the treatment of GIOP. In this study, the osteogenesis-promoting effects of LA against GIOP were investigated and the mechanisms were further probed. Here, the results showed that LA inhibited oxidative stress, suppressed apoptosis and improved osteopenia by promoting the expression of osteogenesis markers, including ALP, COL-I, OCN, BMP-2, RUNX2 and OSX...
June 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28606850/the-impact-of-%C3%AE-lipoic-acid-on-cell-viability-and-expression-of-nephrin-and-znf580-in-normal-human-podocytes
#10
Ulrike Leppert, Allan Gillespie, Miriam Orphal, Karen Böhme, Claudia Plum, Kaj Nagorsen, Janine Berkholz, Reinhold Kreutz, Andreas Eisenreich
Human podocytes (hPC) are essential for maintaining normal kidney function and dysfunction or loss of hPC play a pivotal role in the manifestation and progression of chronic kidney diseases including diabetic nephropathy. Previously, α-Lipoic acid (α-LA), a licensed drug for treatment of diabetic neuropathy, was shown to exhibit protective effects on diabetic nephropathy in vivo. However, the effect of α-LA on hPC under non-diabetic conditions is unknown. Therefore, we analyzed the impact of α-LA on cell viability and expression of nephrin and zinc finger protein 580 (ZNF580) in normal hPC in vitro...
June 10, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28606823/alpha-lipoic-acid-attenuates-acute-neuroinflammation-and-long-term-cognitive-impairment-after-polymicrobial-sepsis
#11
Amanda Della Giustina, Mariana Pereira Goldim, Lucinéia Gainski Danielski, Drielly Florentino, Khiany Mathias, Leandro Garbossa, Aloir Neri Oliveira Junior, Maria Eduarda Fileti, Graciela Freitas Zarbato, Naiana da Rosa, Ana Olívia Martins Laurentino, Jucélia Jeremias Fortunato, Francielle Mina, Tatiani Bellettini-Santos, Josiane Budni, Tatiana Barichello, Felipe Dal-Pizzol, Fabricia Petronilho
Sepsis is a complication of an infection which imbalance the normal regulation of several organ systems, including the central nervous system (CNS). Evidence points towards inflammation and oxidative stress as major steps associated with brain dysfunction in sepsis. Thus, we investigated the α-lipoic acid (ALA) effect as an important antioxidant compound on brain dysfunction in rats. Wistar rats were subjected to sepsis by cecal ligation and perforation (CLP) or sham (control) and treated orally with ALA (200 mg/kg after CLP) or vehicle...
June 10, 2017: Neurochemistry International
https://www.readbyqxmd.com/read/28603627/chronic-treatment-of-r-%C3%AE-lipoic-acid-reduces-blood-glucose-and-lipid-levels-in-high-fat-diet-and-low-dose-streptozotocin-induced-metabolic-syndrome-and-type-2-diabetes-in-sprague-dawley-rats
#12
Hardik Ghelani, Valentina Razmovski-Naumovski, Srinivas Nammi
(R)- α -lipoic acid (ALA), an essential cofactor in mitochondrial respiration and a potential antioxidant, possesses a wide array of metabolic benefits including anti-obesity, glucose lowering, insulin-sensitizing, and lipid-lowering effects. In this study, the curative effects of ALA (100 mg/kg) on a spectrum of conditions related to metabolic syndrome and type 2 diabetes (T2D) were investigated in a high-fat diet (HFD)-fed and low-dose streptozotocin (STZ)-induced rat model of metabolic syndrome and T2D...
June 2017: Pharmacology Research & Perspectives
https://www.readbyqxmd.com/read/28602729/alpha-lipoic-acid-impairs-body-weight-gain-of-young-broiler-chicks-via-modulating-peripheral-ampk
#13
Yufeng Wang, Nadia Everaert, Zhigang Song, Eddy Decuypere, Daniel Vermeulen, Johan Buyse
In mammals, the AMP-activated protein kinase (AMPK) pathways in the central and peripheral tissues coordinately integrate inputs from multiple sources to regulate energy balance. The present study was aimed to explore the potential role of hepatic AMPK in the energy homeostasis of broiler chickens. Diets with 0, 0.05% or 0.1% alpha-lipoic acid (α-LA), a known AMPK inhibitor were provided to broiler chicks for 7days. As a result, α-LA supplementation decreased the relative growth rate of broiler chicks. Hepatic AMPKα2 mRNA levels were significantly upregulated by dietary α-LA, in concert with the increased phosphorylated AMPKα protein levels...
June 8, 2017: Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology
https://www.readbyqxmd.com/read/28598563/alpha-lipoic-acid-prevents-doxorubicin-induced-nephrotoxicity-by-mitigation-of-oxidative-stress-inflammation-and-apoptosis-in-rats
#14
El-Sayed M El-Sayed, Ahmed M Mansour, Waleed S El-Sawy
This study aimed to evaluate the protective effects of alpha lipoic acid (ALA) against doxorubicin (DOX)-induced nephrotoxicity in rats. A single dose of DOX (7.5 mg/kg i.v.) induced nephrotoxicity evidenced by significant elevations in kidney weight, kidney/body weight ratio, serum urea, creatinine, tumor necrosis factor alpha, and renal contents of malondialdehyde, nitric oxide, cyclooxygenase-2, and caspase-3. Also, it causes significant reduction in final body weight, serum albumin, renal contents of reduced glutathione and superoxide dismutase activity...
June 9, 2017: Journal of Biochemical and Molecular Toxicology
https://www.readbyqxmd.com/read/28596150/pain-improvement-with-novel-combination-analgesic-regimens-pain-care-randomized-controlled-trial-protocol
#15
Ian Gilron, Dongsheng Tu, Ronald Holden, Alan C Jackson, Nader Ghasemlou, Scott Duggan, Elizabeth Vandenkerkhof, Roumen Milev
BACKGROUND: Neuropathic pain (NP) (including painful diabetic neuropathy, postherpetic neuralgia, etc) affects approximately 7% to 8% of the population and is associated with a devastating symptom burden as well as a profound economic impact for patients, their families, and the health care system. Current therapies have limited efficacy and dose-limiting adverse effects (AEs). Rational combination therapy with carefully selected NP drugs has shown potential for measurable improvements in pain relief, quality of life, and health care use...
June 8, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28595721/study-of-antioxidant-effects-on-malignant-glioma-cells-by-constructing-a-tumor-microvascular-structure-on-microchip
#16
Hanyang Liu, Mingsha Jie, Ziyi He, Hai-Fang Li, Jin-Ming Lin
In this work, a three-dimensional tumor-microvascular structure was simulated on a microfluidic chip for study of antioxidants effects on malignant glioma cells in vitro. The 3D hydrogel containing lumen was constructed to co-culture endothelial cells and glioma cells to mimic tumor microvascular environment. Macroporous gelatin transglutaminase (TG) hydrogel was prepared with biological and mechanical properties suitable for cells culture and nutrient refresh. To reform a vessel structure, U87 cells were dispersed in the TG-gelatin hydrogel and HUVEC cells were seeded in the lumen of hydrogel...
July 25, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28595582/enhancing-the-quality-and-lipid-stability-of-chicken-nuggets-using-natural-antioxidants
#17
Muhammad Sajid Arshad, Ali Imran, Muhammad Tahir Nadeem, Muhammad Sohaib, Farhan Saeed, Faqir Muhammad Anjum, Joong-Ho Kwon, Shahzad Hussain
BACKGROUND: Current day consumers prefer natural antioxidants to synthetic antioxidants because they are more active. However, the activity generally depends on the specific condition and composition of food. The aim of this study was to investigate the effect of wheat germ oil and α-lipoic acid on the quality characteristics, antioxidant status, fatty acid profile, and sensory attributes of chicken nuggets. METHODS: Six types of diets were prepared for feeding the chickens to evaluate the quality of nuggets made from the leg meat of these experimental animals...
June 8, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28587378/protective-role-of-%C3%AE-lipoic-acid-in-hyperuricemia-induced-endothelial-dysfunction
#18
Hui Zou, Huan Wang, Tongmei Liu, Xiaojie Li, Xiaoduo Zhu, Zheng Wang
The aim of the current study was to determine the effects of α-lipoic acid (LA) on hyperuricemia and endothelial dysfunction, and to uncover the underlying mechanism of its action. A hyperuricemic rat model was established by administration of uric acid (UA) and the rats were orally fed with 2 g/kg/day LA or phosphate-buffered saline. Primary rat aortic endothelial cells were subsequently isolated, and a cell viability assay, apoptosis assay, enzyme nitric oxide synthase (eNOS) activity assay and mitochondrial function assay were all performed...
June 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28584615/does-alpha-lipoic-acid-supplement-regulate-blood-pressure-a-systematic-review-of-randomized-double-blind-placebo-controlled-clinical-trials
#19
REVIEW
Vida Mohammadi, Sirous Dehghani, Gholamreza Askari
Although several animal and human studies have investigated the effect of alpha-lipoic acid (ALA) on blood pressure (BP), these findings are inconsistent. This systematic review of randomized clinical trials was conducted to summarize the evidence on the effect of ALA on BP. PubMed, SCOPUS, and Google Scholar databases were searched based on MESH term ("Thioctic acid" in combination with "Hypertension" and "Blood pressure") to identify related papers published up to December 2015. We summarized the results of the relevant studies in this review...
2017: International Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28579060/human-dihydrolipoamide-dehydrogenase-e3-deficiency-novel-insights-into-the-structural-basis-and-molecular-pathomechanism
#20
REVIEW
Attila Ambrus, Vera Adam-Vizi
This review summarizes our present view on the molecular pathogenesis of human (h) E3-deficiency caused by a variety of genetic alterations with a special emphasis on the moonlighting biochemical phenomena related to the affected (dihydro)lipoamide dehydrogenase (LADH, E3, gene: dld), in particular the generation of reactive oxygen species (ROS). E3-deficiency is a rare autosomal recessive genetic disorder frequently presenting with a neonatal onset and premature death; the highest carrier rate of a single pathogenic dld mutation (1:94-1:110) was found among Ashkenazi Jews...
June 2, 2017: Neurochemistry International
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