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Lipoic acid

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https://www.readbyqxmd.com/read/29143287/lipoic-acid-stimulates-camp-production-in-healthy-control-and-secondary-progressive-ms-subjects
#1
Sarah E Fiedler, Vijayshree Yadav, Amelia R Kerns, Catherine Tsang, Sheila Markwardt, Edward Kim, Rebecca Spain, Dennis Bourdette, Sonemany Salinthone
Lipoic acid (LA) exhibits antioxidant and anti-inflammatory properties; supplementation reduces disease severity and T lymphocyte migration into the central nervous system in a murine model of multiple sclerosis (MS), and administration in secondary progressive MS (SPMS) subjects reduces brain atrophy compared to placebo. The mechanism of action (MOA) of LA's efficacy in suppression of MS pathology is incompletely understood. LA stimulates production of the immunomodulator cyclic AMP (cAMP) in vitro. To determine whether cAMP could be involved in the MOA of LA in vivo, we performed a clinical trial to examine whether LA stimulates cAMP production in healthy control and MS subjects, and whether there are differences in the bioavailability of LA between groups...
November 15, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/29140431/microvascular-adaptations-to-exercise-protective-effect-of-pgc-1-alpha
#2
Andrew O Kadlec, Chad Barnes, Matthew J Durand, David D Gutterman
BACKGROUND: Sedentary behavior and obesity are major risk factors for cardiovascular disease. Regular physical activity has independent protective effects on the cardiovascular system, but the mechanisms responsible remain elusive. Recent studies suggest that the protein peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) participates in the response to exercise training. We hypothesized that the arterioles of athletes maintain dilation to flow despite combined inhibition of multiple vasodilators, but loss of PGC-1α renders these vessels susceptible to inhibition of a single vasodilator pathway...
November 11, 2017: American Journal of Hypertension
https://www.readbyqxmd.com/read/29136144/antioxidants-improve-ivf-outcome-and-subsequent-embryo-development-in-the-mouse
#3
T Truong, D K Gardner
STUDY QUESTION: What is the effect of a combination of three antioxidants (Acetyl-L-Carnitine, N-Acetyl-L-Cysteine and α-Lipoic Acid), present in IVF medium during mouse oocyte and sperm collection, on fertilization and subsequent IVF embryo development? SUMMARY ANSWER: A combination of antioxidants resulted in faster developmental times from the 2-cell stage through to expanded blastocyst stage, accompanied by a significant increase in blastocyst cell number and a reduction of intracellular hydrogen peroxide (H2O2) levels...
November 10, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29128272/cytoprotection-of-lipoic-acid-against-toxicity-induced-by-saxitoxin-in-hippocampal-cell-line-ht-22-through-in-silico-modeling-and-in-vitro-assays
#4
Patrícia Ramos, Marcos Schmitz, Sibele Gama, Aline Portantiolo, Michael Gonzalez Durruthy, Ana Paula de Souza Votto, Luisa Rodrigues Cornetet, Karina Dos Santos Machado, Adriano Wehrli, Mariana Zancan Tonel, Solange Binotto Fagan, João Sarkis Yunes, José Maria Monserrat
Saxitoxins (STXs) are potent neurotoxins that block voltage-gated channels in neurons and induce cytotoxicity. These toxins not only can generate reactive oxygen species but also can alter antioxidant levels, promoting oxidative stress. Under this pro-oxidant situation, the use of the antioxidant lipoic acid (LA) can represent a chemoprotective alternative to minimize the deleterious effects induced by neurotoxins as STXs. P-glycoprotein (P-gp) is a well-known ATP-binding cassette (ABC) transporter that plays a crucial role in the extrusion of toxic substances, decreasing their accumulation and potential intracellular effects in virtue of its broad substrate specificity, its expression in many excretory tissues and its large efflux capacity...
November 8, 2017: Toxicology
https://www.readbyqxmd.com/read/29127425/the-effects-of-vitamin-e-or-lipoic-acid-supplementation-on-oxyphytosterols-in-subjects-with-elevated-oxidative-stress-a-randomized-trial
#5
Sabine Baumgartner, Ronald P Mensink, Guido R Haenen, Aalt Bast, Christoph J Binder, Otto Bekers, Constanze Husche, Dieter Lütjohann, Jogchum Plat
Despite increased serum plant sterol concentrations after consumption of plant sterol enriched margarines, plasma oxyphytosterol concentrations were not increased in healthy subjects. Here, we assessed plasma oxyphytosterol concentrations and whether they are affected by antioxidants in subjects with elevated oxidative stress. Twenty subjects with impaired glucose tolerance (IGT) or type 2 diabetes (DM2) consumed for 4 weeks placebo, vitamin E (804 mg/d) or lipoic acid capsules (600 mg/d). Plasma and blood cell oxyphytosterol and oxycholesterol concentrations were determined in butylated hydroxytoluene-enriched EDTA plasma via GC-MS...
November 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29126071/%C3%AE-lipoic-acid-improves-abnormal-behavior-by-mitigation-of-oxidative-stress-inflammation-ferroptosis-and-tauopathy-in-p301s-tau-transgenic-mice
#6
Yan-Hui Zhang, Da-Wei Wang, Shuang-Feng Xu, Shuai Zhang, Yong-Gang Fan, Ying-Ying Yang, Shi-Qi Guo, Shan Wang, Tian Guo, Zhan-You Wang, Chuang Guo
Alzheimer's disease (AD) is the most common neurodegenerative disease and is characterized by neurofibrillary tangles (NFTs) composed of Tau protein. α-Lipoic acid (LA) has been found to stabilize the cognitive function of AD patients, and animal study findings have confirmed its anti-amyloidogenic properties. However, the underlying mechanisms remain unclear, especially with respect to the ability of LA to control Tau pathology and neuronal damage. Here, we found that LA supplementation effectively inhibited the hyperphosphorylation of Tau at several AD-related sites, accompanied by reduced cognitive decline in P301S Tau transgenic mice...
November 7, 2017: Redox Biology
https://www.readbyqxmd.com/read/29125108/lipoic-acid-combined-with-epalrestat-versus-lipoic-acid-in-treating-diabetic-peripheral-neuropathy-a-meta-analysis
#7
Xiao-Tong Wang, Hai-Xiong Lin, Shu-Ai Xu, Ying-Kun Lu
Objective To compare the clinical effectiveness of lipoic acid combined with epalrestat versus lipoic acid in treating diabetic peripheral neuropathy(DPN). Methods Randomized controlled trials(RCTs) and clinical controlled trials on lipoic acid versus epalrestat for DPN before February 2016 were searched through five databases:CNKI,CBM,VIP,Wanfang,and PubMed. The quality of the included trials were assessed using Cochrane software and Jadad scores. Data were analyzed with Review Manager 5.3 software. Results Nine studies were included in the analysis...
October 30, 2017: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
https://www.readbyqxmd.com/read/29122663/ftir-study-of-secondary-structure-changes-in-epidermal-growth-factor-by-gold-nanoparticle-conjugation
#8
T T Bhattacharjee, M L Castilho, I R de Oliveira, V P S Jesus, K C Hewitt, L Raniero
Conformation of protein is vital to its function, but may get affected when processing to manufacture products. It is therefore important to understand structural changes during each step of production. In this study, we investigate secondary structure changes in the targeting protein Epidermal Growth Factor (EGF) during synthesis of theranostic bifunctional nanoparticle, devised for Photodynamic therapy of breast cancer. We acquired FTIR spectra of EGF; unconjugated, post treatment with α-lipoic acid, attached to gold nanoparticle, and bound to the bifunctional nanoprobe...
November 6, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29122497/further-delineation-of-the-phenotypic-spectrum-of%C3%A2-isca2-defect-a-report-of-ten-new-cases
#9
Majid Alfadhel, Marwan Nashabat, Muhammad Talal Alrifai, Hesham Alshaalan, Fuad Al Mutairi, Saif A Al-Shahrani, Barbara Plecko, Rawan Almass, Maysoon Alsagob, Faten B Almutairi, Ahmed Al-Rumayyan, Waleed Al-Twaijri, Mohammed Al-Owain, Robert W Taylor, Namik Kaya
Iron-Sulfur Cluster (ISC) biogenesis is a vital cellular process required to produce various ISC-containing proteins. These ISC proteins are responsible for essential functions such as glycine cleavage and the formation of lipoic acid, an essential cofactor of respiratory chain complexes. Defects in ISC biogenesis lead to multiple mitochondrial dysfunction syndromes including: ISCA2 with infantile onset leukodystrophy. Recently, a founder mutation, c.229G > A, p.Gly77Ser in ISCA2 was reported to cause Multiple Mitochondrial Dysfunction Syndrome type 4...
October 16, 2017: European Journal of Paediatric Neurology: EJPN
https://www.readbyqxmd.com/read/29115484/lipoic-acid-alleviates-l%C3%A2-dopa%C3%A2-induced-dyskinesia-in-6%C3%A2-ohda-parkinsonian-rats-via-anti%C3%A2-oxidative-stress
#10
Su-Fang Zhang, Cheng-Long Xie, Jing-Ya Lin, Mei-Hua Wang, Xi-Jin Wang, Zhen-Guo Liu
Levodopa (L‑DOPA) is the gold standard for symptomatic treatment of Parkinson's disease (PD); however, long‑term therapy is associated with the emergence of L‑DOPA‑induced dyskinesia (LID). Nigral dopaminergic cell loss determines the degree of drug exposure and time required for the initial onset of LID. Accumulating evidence indicates that α‑lipoic acid (ALA) decreases this nigral dopaminergic cell loss. However, until now, the precise mechanisms of ALA have only been partially understood in LID...
November 6, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29100334/paradoxical-effects-of-137-cs-irradiation-on-pharmacological-stimulation-of-reactive-oxygen-species-in-hippocampal-slices-from-apoe2-and-apoe4-mice
#11
Laura E Villasana, Tunde Akinyeke, Sydney Weber, Jacob Raber
In humans, apoE, which plays a role in repair, is expressed in three isoforms: E2, E3, and E4. E4 is a risk factor for age-related cognitive decline (ACD) and Alzheimer's disease (AD), particularly in women. In contrast, E2 is a protective factor for ACD and AD. E2 and E4 might also differ in their response to cranial (137)Cs irradiation, a form of radiation typically used in a clinical setting for the treatment of cancer. This might be mediated by reactive oxygen species (ROS) in an-apoE isoform-dependent fashion...
September 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/29098625/c-ebpb-cited4-in-exercised-heart
#12
Shengguang Ding, Tianyi Gan, Meiyi Song, Qiying Dai, Haitao Huang, Yiming Xu, Chongjun Zhong
C/EBPB is a crucial transcription factor, participating in a variety of biological processes including cell proliferation, differentiation and development. In the cardiovascular system, C/EBPB-CITED4 signaling is known as a signaling pathway mediating exercise-induced cardiac growth. After its exact role in exercised heart firstly reported in 2010, more and more evidence confirmed that. MicroRNA (e.g. miR-222) and many molecules (e.g. Alpha-lipoic acid) can regulate this pathway and then involve in the cardiac protection effect induced by endurance exercise training...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29096112/modulation-of-wettability-gradient-and-adhesion-on-self-assembled-monolayer-by-counterion-exchange-and-ph
#13
Jaroslav Mosnáček, Anton Popelka, Josef Osicka, Jaroslav Filip, Marketa Ilcikova, Jozef Kollar, Ammar B Yousaf, Tomas Bertok, Jan Tkac, Peter Kasak
In this study, two quaternary ammonium salts derived from l-lipoic acid were applied for self-assembled monolayers formation on rough structured gold surface. The derivatives differ in functionality since one possesses simple quaternary ammonium group whereas the other one is carboxybetaine ester containing quaternary ammonium group with pH hydrolysable ester group as a pendant. The response of surface wettability to ion exchange between Cl(-) and perfluorooctanoate, kinetics and gradient wettability were examined by water contact angle measurement and confirmed by X-ray photoelectron spectroscopy...
October 25, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29090431/modulatory-effects-of-alpha-lipoic-acid-ala-administration-on-insulin-sensitivity-in-obese-pcos-patients
#14
A D Genazzani, K Shefer, D Della Casa, A Prati, A Napolitano, A Manzo, G Despini, T Simoncini
PURPOSE: To evaluate the efficacy of alpha-lipoic acid (ALA) administration on hormonal and metabolic parameters of obese PCOS patients. METHODS: A group of 32 obese PCOS patients were selected after informed consent. 20 patients referred to have first grade relatives with diabetes type I or II. Hormonal and metabolic parameters as well as OGTT were evaluated before and after 12 weeks of ALA integrative administration (400 mg per os every day). RESULTS: ALA administration significantly decreased insulin, glucose, BMI and HOMA index...
October 31, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29077914/effects-of-dietary-vitamin-c-vitamin-e-and-alpha-lipoic-acid-supplementation-on-the-antioxidant-defense-system-and-immune-related-gene-expression-in-broilers-exposed-to-oxidative-stress-by-dexamethasone
#15
H K El-Senousey, B Chen, J Y Wang, A M Atta, F R Mohamed, Q H Nie
Vitamin C, vitamin E, and alpha-lipoic acid (ALA) are potent nutritional antioxidants, which are important for enhancing immunity. This study compared the effects of supplementation with vitamin C, vitamin E, or ALA on the antioxidant defense system and the expression of immune-related genes under oxidative stress induced by dexamethasone (DEX) in broilers. In total, 240 one-day-old female Recessive White Rock chickens were assigned randomly to either a basal diet (control group) or basal diet supplemented with vitamin C (200 mg/kg diet), vitamin E (100 mg/kg), or ALA (500 mg/kg) for 28 d starting from hatching...
October 25, 2017: Poultry Science
https://www.readbyqxmd.com/read/29069822/alpha-lipoic-acid-attenuates-radiation-induced-oral-mucositis-in-rats
#16
Jin Hyun Kim, Myeong Hee Jung, Jin Pyeong Kim, Hyun-Jung Kim, Jung Hwa Jung, Jong Ryeal Hahm, Ki Mun Kang, Bae-Kwon Jeong, Seung Hoon Woo
PURPOSE: Radiotherapy is currently one of the main treatment modalities for head and neck cancer; however, it also results in severe toxicity to the normal tissue, to the detriment of patients. This study aimed to investigate whether alpha lipoic acid (ALA) could protect against radiation-induced oral mucositis in a rat model. RESULTS: On post-irradiation days 4 and 7, the epithelial layer on oral mucosa showed pronounced injury (shortening of the layer) and it is diminished by ALA pretreatment before radiation...
September 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/29059768/re-%C3%AE-lipoic-acid-treatment-prevents-cystine-urolithiasis-in-a-mouse-model-of-cystinuria
#17
Dean G Assimos
No abstract text is available yet for this article.
November 2017: Journal of Urology
https://www.readbyqxmd.com/read/29058588/effect-of-infla-kine-supplementation-on-the-gene-expression-of-inflammatory-markers-in-peripheral-mononuclear-cells-and-on-c-reactive-protein-in-blood
#18
Nina A Mikirova, Santosh Kesari, Thomas E Ichim, Neil H Riordan
BACKGROUND: Chronic inflammation is a predisposing factor to numerous degenerative diseases including cancer, heart failure and Alzheimer's disease. Infla-Kine is a natural supplement comprised of a proprietary blend of Lactobacillus fermentum extract, burdock seed (arctigenin), zinc, alpha lipoic acid, papaya enzyme and an enhanced absorption bio-curcumin complex (BCM-95(®)). METHODS: Infla-Kine was administered twice daily to 24 health volunteers for 4 weeks...
October 20, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29056677/effect-of-oral-alpha-lipoic-acid-in-preventing-the-genesis-of-canine-diabetic-cataract-a-preliminary-study
#19
David L Williams
Blinding cataract is a significant effect of canine diabetes with 75% of animals affected two years after diagnosis. Lens opacification occurs primarily through the generation of sorbitol, a sugar alcohol, through the action of aldose reductase (AR). The osmotic effect of sorbitol draws water into the lens, causing opacification. Inhibition of AR should thus prevent the generation of cataracts. A topical AR inhibitor has been shown to have this effect, as has the commercially available neutraceutical OcuGLO, containing the AR inhibitor alpha lipoic acid (ALA) together with other plant-based antioxidants...
March 16, 2017: Veterinary Sciences
https://www.readbyqxmd.com/read/29056428/a-lipoylated-metabolic-protein-released-by-staphylococcus-aureus-suppresses-macrophage-activation
#20
James P Grayczyk, Cameron J Harvey, Irina Laczkovich, Francis Alonzo
The virulence factors of pathogenic microbes often have single functions that permit immune suppression. However, a proportion possess multiple activities and are considered moonlighting proteins. By examining secreted virulence factors of Staphylococcus aureus, we determine that the bacterial lipoic acid synthetase LipA suppresses macrophage activation. LipA is known to modify the E2 subunit of the metabolic enzyme complex pyruvate dehydrogenase (E2-PDH) with a fatty acid derivative, lipoic acid, yielding the metabolic protein lipoyl-E2-PDH...
November 8, 2017: Cell Host & Microbe
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