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Carcinoma of pancreas

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https://www.readbyqxmd.com/read/28722124/pancreatic-undifferentiated-carcinoma-with-osteoclast-like-giant-cells-is-genetically-similar-to-but-clinically-distinct-from-conventional-ductal-adenocarcinoma
#1
Claudio Luchini, Antonio Pea, Gemma Lionheart, Andrea Mafficini, Alessia Nottegar, Nicola Veronese, Peter Chianchiano, Lodewijk A A Brosens, Michaël Noë, G Johan A Offerhaus, Raluca Yonescu, Yi Ning, Giuseppe Malleo, Giulio Riva, Paola Piccoli, Ivana Cataldo, Paola Capelli, Giuseppe Zamboni, Aldo Scarpa, Laura D Wood
Undifferentiated carcinoma of the pancreas with osteoclast-like giant cells (UCOGC) is currently considered a morphologically and clinically distinct variant of pancreatic ductal adenocarcinoma (PDAC). In this study, we report clinical and pathological features of a series of 22 UCOGC, including the whole exome sequencing of 8 UCOGC. We observed that 60% of the UCOGC contained a well-defined epithelial component and that patients with pure UCOGC had a significantly better prognosis than did those with an UCOGC with an associated epithelial neoplasm...
July 19, 2017: Journal of Pathology
https://www.readbyqxmd.com/read/28722109/genomic-signatures-of-adenosquamous-carcinoma-of-the-pancreas-pasc
#2
Yuan Fang, Zhe Su, Jing Xie, Ruidong Xue, Qi Ma, Yanmeng Li, Yifan Zhao, Zeshi Song, Xiongxiong Lu, Hongwei Li, Chenghong Peng, Bai Fan, Baiyong Shen
In pancreatic cancer (PC), adenosquamous carcinoma of the pancreas (PASC) containing both ductal adenocarcinoma and squamous carcinoma in the same tumor represents ~ 4% of the total incidence. To date, the genomic features of this mixed tumor are still unknown. We analyzed genomes of 17 PASCs and 34 ductal adenocarcinomas (PDACs), showing that PASC carried highly enriched TP53 mutations and 3p loss compared to PDAC. Furthermore, we uncovered that adenomatous and squamous components of PASC harbored comparable genomic alterations, suggesting that two cellular components are developed from the same progenitor cancer cells...
July 19, 2017: Journal of Pathology
https://www.readbyqxmd.com/read/28708232/primary-signet-ring-cell-carcinoma-of-the-pancreas-with-a-good-response-to-chemotherapy-case-report-and-literature-review
#3
Milan Radojkovic, Dragana Ilic, Ivan Ilic
PURPOSE: Although pancreatic cancer is a common malignancy, signet ring cell carcinoma of the pancreas is a very rare histologic type with only 6 cases reported so far. We present a patient with primary signet ring cell carcinoma of the pancreas and a good response to neoadjuvant chemotherapy. CASE REPORT: A 67-year-old woman presented at a regional hospital with a 2-week history of painless progressive jaundice. Abdominal computed tomography showed a tumor in the head of the pancreas, 4...
July 5, 2017: Tumori
https://www.readbyqxmd.com/read/28705205/clinicopathological-features-and-prognosis-of-gastroenteropancreatic-neuroendocrine-neoplasms-in-a-chinese-population-a-large-retrospective-single-centre-study
#4
Meng Zhang, Ping Zhao, Xiaodan Shi, Ahong Zhao, Lianfeng Zhang, Lin Zhou
BACKGROUND: Gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) are the most common type of neuroendocrine tumors, accounting for more than half of neuroendocrine neoplasms (NENs). We performed a retrospective study in our center to investigate the clinicopathological features, risk factors of metastasis, and prognosis of GEP-NENs in a Chinese population. METHODS: Four hundred forty patients with GEP-NENs treated at the First Affiliated Hospital of Zhengzhou University between January 2011 and March 2016 were analyzed retrospectively...
July 13, 2017: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/28702871/expression-of-podoplanin-in-stromal-fibroblasts-plays-a-pivotal-role-in-the-prognosis-of-patients-with-pancreatic-cancer
#5
Kazuyoshi Hirayama, Hiroshi Kono, Yuuki Nakata, Yoshihiro Akazawa, Hiroyuki Wakana, Hisataka Fukushima, Hideki Fujii
PURPOSE: To investigate the role of podoplanin (PDPN) expression in invasive ductal carcinoma of the pancreas (IDCP) in humans. METHODS: Tumor samples were obtained from 95 patients with IDCP. Immunohistochemical staining was done to evaluate the expression of PDPN in cancer tissues. RESULTS: PDPN was detected predominantly in stromal fibroblasts, stained with α-smooth muscle actin. The cutoff value of PDPN-positive areas was calculated according to a histogram...
July 12, 2017: Surgery Today
https://www.readbyqxmd.com/read/28700485/value-of-contrast-enhanced-ultrasound-in-differential-diagnosis-of-solid-lesions-of-pancreas-slp-a-systematic-review-and-a-meta-analysis
#6
Li Ran, Wenli Zhao, Ye Zhao, Huaien Bu
BACKGROUND: Contrast-enhanced ultrasound (CEUS) is considered a novel method for diagnosing pancreatic cancer, but currently, there is no conclusive evidence of its accuracy. Using CEUS in discriminating between pancreatic carcinoma and other pancreatic lesions, we aimed to evaluate the diagnostic accuracy of CEUS in predicting pancreatic tumours. METHODS: Relevant studies were selected from the PubMed, Cochrane Library, Elsevier, CNKI, VIP, and WANFANG databases dating from January 2006 to May 2017...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28700444/multi-institutional-validation-study-of-pancreatic-cyst-fluid-protein-analysis-for-prediction-of-high-risk-intraductal-papillary-mucinous-neoplasms-of-the-pancreas
#7
Mohammad A Al Efishat, Marc F Attiyeh, Anne A Eaton, Mithat Gönen, Denise Prosser, Anna E Lokshin, Carlos Fernández-Del Castillo, Keith D Lillemoe, Cristina R Ferrone, Ilaria Pergolini, Mari Mino-Kenudson, Neda Rezaee, Marco Dal Molin, Matthew J Weiss, John L Cameron, Ralph H Hruban, Michael I D'Angelica, T Peter Kingham, Ronald P DeMatteo, William R Jarnagin, Christopher L Wolfgang, Peter J Allen
OBJECTIVE: Preliminary work by our group suggested that proteins within the pancreatic cyst fluid (CF) may discriminate degree of IPMN dysplasia. We sought to externally validate these markers and determine whether their inclusion in a preoperative clinical nomogram could increase diagnostic accuracy. SUMMARY BACKGROUND DATA: IPMN is the most common radiographically identifiable precursor to pancreatic cancer; however, the timing and frequency of its malignant progression are unknown, and there are currently no reliable preoperative tests that can determine the grade of dysplasia in IPMN...
July 11, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28693619/successful-pregnancy-after-mucinous-cystic-neoplasm-with-invasive-carcinoma-of-the-pancreas-in-a-patient-with-polycystic-ovarian-syndrome-a-case-report
#8
Conisha Holloman, S J Carlan, Lohini Sundharkrishnan, Angela Guzman, Mario Madruga
BACKGROUND: The incidence of invasive cancer within a mucinous cystic neoplasm of the pancreas varies between 6 and 36%. Polycystic ovarian syndrome is a disorder characterized by hyperandrogenism and anovulatory infertility. One surgical treatment that can restore endocrine balance and ovulation in polycystic ovarian syndrome is partial ovarian destruction. Successful pregnancies following preconception pancreaticoduodenectomies (Whipple procedures) and chemoradiation to treat pancreatic neoplasms have been reported rarely but none were diagnosed with pre-cancer polycystic ovarian syndrome-associated infertility...
July 11, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28693204/treatment-of-a-mixed-acinar-endocrine-carcinoma-with-uptake-on-68-gallium-dotatoc-positron-emission-tomography-computed-tomography-a-case-report
#9
Anneleen De Both, Marc De Man, Roberto Troisi, Hans Van Vlierberghe, Anne Hoorens, Karen Geboes
The case of a 35-year old female patient with a diagnosis of metastatic mixed acinar-endocrine carcinoma (MAEC) is investigated in the present study. The patient was believed to have a well-differentiated neuroendocrine tumor (NET) with a high Ki-67 index and uptake on (68)Gallium-DOTATOC positron emission tomography-computed tomography for 9 years, and was treated accordingly. The patient had long lasting disease control by treatment with sunitinib, and a response was observed in numerous lesions with peptide receptor radionuclide therapy (PRRT)...
July 2017: Oncology Letters
https://www.readbyqxmd.com/read/28687431/resectable-invasive-ipmn-versus-sporadic-pancreatic-adenocarcinoma-of-the-head-of-the-pancreas-should-these-two-different-diseases-receive-the-same-treatment-a-matched-comparison-study-of-the-french-surgical-association-afc
#10
P Duconseil, J Périnel, A Autret, M Adham, A Sauvanet, L Chiche, J-Y Mabrut, J-J Tuech, C Mariette, N Régenet, J-M Fabre, P Bachellier, J-R Delpéro, F Paye, O Turrini
PURPOSE: To compare survival and impact of adjuvant chemotherapy in patients who underwent pancreaticoduodenectomy (PD) for invasive intraductal papillary mucinous neoplasm (IIPMN) and sporadic pancreatic ductal adenocarcinoma (PDAC). METHODS: From 2005 to 2012, 240 patients underwent pancreatectomy for IIPMN and 1327 for PDAC. Exclusion criteria included neoadjuvant treatment, pancreatic resection other than PD, vascular resection, carcinoma in situ, or <11 examined lymph nodes...
June 29, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28685876/eus-fna-of-the-merkel-cell-carcinoma-metastasis-to-the-pancreas-cytomorphology-and-immunocytochemistry-on-direct-cytological-smears
#11
T Stoos-Veic, M Tadic, G Aralica, V Milicic, C Tomasovic-Loncaric
OBJECTIVE: To report two cases of Merkel cell carcinoma (MCC) metastatic to the pancreas diagnosed with endoscopic ultrasound-guided-fine needle aspiration (EUS-FNA) and to add the case of concomitant chronic lymphocytic leukaemia/small lymphocytic lymphoma (CLL/SLL) and MCC to the literature. The aim is to alert the cytopathologists once more to the problems of differential diagnosis of pancreatic metastasis of MCC and to describe the possibilities of ancillary methods performed on direct cytological smears...
July 6, 2017: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/28684728/a-rare-case-of-sarcomatoid-carcinoma-of-the-lung-with-spine-metastasis-including-a-literature-review
#12
Hafiza Sobia Arshad, Rizwan Ahmed Dudekula, Masooma Niazi, Sandeep Malik, Misbahuddin Khaja
BACKGROUND Sarcomatoid carcinoma is a rare, aggressive, malignant cancer composed of sarcoma and sarcoma-like components, and can occur in different organs such as the thyroid gland, bone, skin, breast, pancreas, liver, urinary tract, and lung. Pulmonary sarcomatoid carcinoma accounts for only a small percentage of lung cancers and has histological variants that include pleomorphic carcinoma, giant cell carcinoma, spindle cell carcinoma, carcinosarcoma, and pulmonary blastoma. CASE REPORT Here, we present a case of sarcomatoid carcinoma in a 63-year-old HIV-positive Hispanic male who presented with back pain, dry cough, and weight loss...
July 7, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/28681213/hepatoid-adenocarcinoma-of-unknown-primary-masquerading-as-a-pancreatic-tumor
#13
Epameinondas Dogeas, Lan Peng, Michael A Choti
Hepatoid adenocarcinoma is a rare type of extrahepatic cancer characterized by hepatocellular carcinoma-like histology. We present a case of a large solitary mass in the peripancreatic region found to be an isolated lymph node metastasis from an unknown primary hepatoid adenocarcinoma masquerading as an acinar carcinoma of the pancreas.
July 5, 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/28673644/a-rectal-metastases-from-malignant-mucinous-cystic-neoplasm-of-the-pancreas-mimicking-a-rectal-carcinoma
#14
Silvia Carrara, Milena Di Leo, Paola Spaggiari, Pietro Francesco Bagnoli, Alessandro Repici
No abstract text is available yet for this article.
June 30, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28670511/radioactive-iodine-therapy-and-glucose-tolerance
#15
REVIEW
Roghaieh Samadi, Babak Shafiei, Fereidoun Azizi, Asghar Ghasemi
Radioactive iodine therapy is commonly used as an adjuvant therapy in follicular and papillary thyroid carcinoma (PTC) and in the treatment of Graves' disease (GD). The basis of this therapy is the accumulation of radioactive iodine by the sodium-iodide symporter (NIS) in the thyroid gland. Expression of NIS by extrathyroidal tissues such as islets of pancreas has been reported. Radioactive iodine uptake by pancreatic beta-cells can potentially damage these cells. In this study, we discuss the possible associations between radioactive iodine and glucose intolerance...
July 2017: Cell Journal
https://www.readbyqxmd.com/read/28660524/acinar-cell-carcinoma-of-pancreas-a-case-report-and-review-of-literature
#16
Hemanth Makineni, Ramakrishnan Ayloor Seshadri, Shirley Sundersingh
No abstract text is available yet for this article.
June 29, 2017: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/28660521/primary-squamous-cell-carcinoma-of-the-pancreas-a-case-report-and-literature-review
#17
Bader A Alajlan, Cory T Bernadt, Vladimir M Kushnir
No abstract text is available yet for this article.
June 29, 2017: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/28657939/should-patients-with-cystic-lesions-of-the-pancreas-undergo-long-term-radiographic-surveillance-results-of-3024-patients-evaluated-at-a-single-institution
#18
Sharon A Lawrence, Marc A Attiyeh, Kenneth Seier, Mithat Gönen, Mark Schattner, Dana L Haviland, Vinod P Balachandran, T Peter Kingham, Michael I D'Angelica, Ronald P DeMatteo, Murray F Brennan, William R Jarnagin, Peter J Allen
OBJECTIVE: In 2015, the American Gastroenterological Association recommended the discontinuation of radiographic surveillance after 5 years for patients with stable pancreatic cysts. The current study evaluated the yield of continued surveillance of pancreatic cysts up to and after 5 years of follow up. METHODS: A prospectively maintained registry of patients evaluated for pancreatic cysts was queried (1995-2016). Patients who initially underwent radiographic surveillance were divided into those with <5 years and ≥5 years of follow up...
June 27, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28655083/-anatomic-study-and-clinical-practice-of-mesopancreas-and-total-mesopancreatic-excision
#19
J Y Xu, Y R Chen, C Liu, L Tian, J W Wang, D Cui, Y Wang, W G Zhang, Y M Yang
Objective: To explore the anatomical characteristics of the mesopancreas, to define the range of the total mesopancreas excision and to evaluate the feasibility, safety and effectiveness in the treatment of pancreatic cancer. Methods: A regional anatomical and pathological study was performed on 14 cadavers with large slices and paraffin sections. The clinical and pathological data of 58 consecutive patients underwent total mesopancreas excision for pancreatic head carcinoma from January 2013 to December 2015 were prospectively collected and analysed...
July 1, 2017: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/28653152/-r1-resection-for-pancreatic-carcinoma
#20
REVIEW
G F Weber, S Kersting, F Haller, R Grützmann
BACKGROUND: Surgery is the only potentially curative therapeutic approach in patients with pancreatic ductal adenocarcinoma (PDAC); however, achieving a negative (R0) resection margin is not always possible. OBJECTIVE: The impact of R1 resection margins on survival rates and treatment options (surgical and multimodal) for intraoperatively and postoperatively identified R1 resection margins. RESULTS: For intraoperatively diagnosed R1 resection margins, a re-resection (e...
June 26, 2017: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
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