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Carcinoma of gallbladder

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https://www.readbyqxmd.com/read/29668579/gallbladder-cancer-with-tumor-thrombus-in-the-portal-vein-a-case-report
#1
Xiao-Zhen Zhang, Jian-Jun Tu, Wei Chen, Tao Ma, Xue-Li Bai, Ting-Bo Liang
RATIONALE: Gallbladder cancer (GBC) is a highly fatal malignancy. Due to its invasiveness and delayed diagnosis, many GBC patients are diagnosed with synchronous liver and hepatoduodenal ligament involvement. In our case, we report a gallbladder cancer with portal vein thrombus. PATIENT CONCERNS: A 60-year-old woman presented with persistent upper abdominal dull pain for 2 months. DIAGNOSES: Ultrasound examination showed gallbladder carcinoma invading liver segment IV, and a tumor thrombus in the left and right main portal trunk...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29659084/hepatobiliary-and-pancreatic-a-case-of-pure-squamous-cell-carcinoma-of-the-gallbladder
#2
M Kobayashi, S Ryozawa, K Nagata
No abstract text is available yet for this article.
May 2018: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29650922/-gallbladder-carcinoma-that-occurred-50-years-after-cholecystojejunostomy
#3
Masaru Kubota, Yasuji Hashimoto, Hiroki Imamura, Yuriko Yagi, Takashi Noma, Yukako Mokutani, Kenichi Nagai, Hajime Hirose, Yoshihito Ide, Jin Matsuyama, Yukio Fukushima, Yousuke Nishioka, Masashi Takeda, Shigeyuki Tamura, Yo Sasaki
Creation of a cholecystojejunostomy has been recommended as one option in the palliation of biliary obstruction due to pancreatic carcinoma.However, it was a technique used for biliary drainage for acute cholecystitis a long time ago.We describe a patient who underwent a cholecystojejunostomy for acute cholecystitis 50 years prior to presentation, and then revealed a gallbladder carcinoma.
March 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29650819/-a-case-report-of-neuroendocrine-carcinoma-in-the-gall-bladder-showing-recurrence-shortly-after-surgery
#4
Yoshihiro Uchino, Sonofu Taketani, Nobuhisa Hirayu, Koji Shiota, Hironobu Sou, Satoshi Taniwaki, Tetsuo Imamura
A55 -year-old woman with a 10×8mm protuberant gallbladder lesion visited our hospital. To determine possible malignancy, she underwent laparoscopic excision biopsy of the gallbladder, and pathological findings revealed an endocrine carcinoma in the gallbladder. Surgery involved extrahepatic bile duct resection, gallbladder bed resection, and hepatic portal lymph node resection. Recurrence in the peritoneal lymph node was observed in the early postoperative period. Chemotherapy was initiated with cisplatin and irinotecan, and continues 18 months post-operatively...
April 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29642951/use-of-oxidized-regenerated-cellulose-to-achieve-hemostasis-during-laparoscopic-cholecystectomy-a-retrospective-cohort-analysis
#5
Emilia Masci, Giuseppe Faillace, Mauro Longoni
OBJECTIVE: Laparoscopic cholecystectomy is the first-choice treatment for symptomatic cholelithiasis. Though generally safe, this procedure is not without complications, with bleeding the most frequent cause of conversion to open cholecystectomy. Oxidized regenerated cellulose (ORC) added to conventional hemostatic strategies, is widely used to control bleeding during surgery despite limited evidence supporting its use. This retrospective study analyzed patients undergoing laparoscopic cholecystectomy in an Italian center over a 16-month period, between October 2014 and February 2016, who experienced uncontrollable bleeding despite the use of conventional hemostatic strategies, requiring the addition of ORC gauze (Emosist® )...
April 11, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29626304/efficacy-of-the-gallbladder-cancer-predictive-risk-score-based-on-pathological-findings-a-propensity-score-matched-analysis
#6
Tetsuya Mochizuki, Tomoyuki Abe, Hironobu Amano, Keiji Hanada, Minoru Hattori, Tsuyoshi Kobayashi, Masahiro Nakahara, Hideki Ohdan, Toshio Noriyuki
BACKGROUND: The optimal prognostic predictive system for gallbladder carcinoma (GBC) has not been established. The gallbladder cancer predictive risk score (GBRS) based on pathological findings identifies incidental GBC patients at risk of recurrence. OBJECTIVE: We aimed to validate the prognostic ability of the GBRS in all GBC patients following curative surgery. METHODS: Fifty-six patients with GBC who underwent curative surgery between 1996 and 2016 were included in this study...
April 6, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29624208/gemcitabine-based-chemotherapy-for-advanced-biliary-tract-carcinomas
#7
REVIEW
Omar Abdel-Rahman, Zeinab Elsayed, Hesham Elhalawani
BACKGROUND: Biliary tract cancers are a group of rare heterogeneous malignant tumours. They include intrahepatic and extrahepatic cholangiocarcinomas, gallbladder carcinomas, and ampullary carcinomas. Surgery remains the optimal modality of therapy leading to long-term survival for people diagnosed with resectable biliary tract carcinomas. Unfortunately, most people with biliary tract carcinomas are diagnosed with either unresectable locally-advanced or metastatic disease, and they are only suitable for palliative chemotherapy or supportive care...
April 6, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29623349/three-cases-of-intracystic-papillary-neoplasm-of-gallbladder
#8
Naruki Mizobuchi, Jiro Munechika, Nobuyuki Takeyama, Yoshimitsu Ohgiya, Nobuyuki Ohike, Ryosuke Abe, Noritsugu Takahama, Osamu Miyagami, Kumi Hatano, Kumiko Ishizuka, Masanori Hirose, Takehiko Gokan
Intracystic papillary neoplasm (ICPN) of gallbladder is a comparatively new concept and is described as pre-malignant lesions in Nakanuma et al. (In: Bosman et al. (eds) WHO Classification of Tumours of the Digestive System, World Health Organization of Tumours, IARC, Lyon, 2010). ICPN with high-grade intraepithelial neoplasia is understood to include intraepithelial carcinoma or noninvasive carcinoma. And lesions with invasive cancer components are classified as ICPN with an associated invasive carcinoma [1]...
April 6, 2018: Abdominal Radiology
https://www.readbyqxmd.com/read/29600228/incidental-gallbladder-carcinoma-utility-of-histopathological-evaluation-of-routine-cholecystectomy-specimens
#9
Vidya Jha, Preeti Sharma, K Ashish Mandal
Background: Incidental gallbladder carcinoma (IGBC) is rare cancer diagnosed during or after cholecystectomy done for benign gallbladder disease. The concern whether routine histopathological examination is needed for all cholecystectomy specimens still remains debatable. Materials and Methods: Twenty patients diagnosed with IGBC over a period of 2 years were retrospectively reviewed. Clinical details including clinical presentation, preoperative ultrasound (USG) findings, and macroscopic features were retrieved...
January 2018: South Asian Journal of Cancer
https://www.readbyqxmd.com/read/29598788/gene-silencing-of-heparanase-results-in-suppression-of-invasion-and-migration-of-gallbladder-carcinoma-cells
#10
Hao Jin, Min Cui
This study investigated the effect of transcriptional gene silencing of the heparanase gene on standard gallbladder carcinoma cells (GBC-SD). The miRNAs targeting the promoter region and coding region of the heparanase gene were designed and synthesized. We transfected four recombinant miRNA vectors into GBC-SD. We performed the wound healing assays and invasion assays. The result shows that the heparanase expression was significantly decreased by recombinant vectors in transfected GBC-SD cells (p < 0...
March 29, 2018: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/29596949/epidemiological-dimensions-of-the-association-between-type-2-diabetes-and-cancer-a-review-of-observational-studies
#11
REVIEW
Carlotta Sacerdote, Fulvio Ricceri
Type 2 diabetes (T2D) is a major cause of complications and death in many countries. The possible causal relation between T2D and cancer has been the aim of many research investigations. In view of the importance of the topic we carried out a narrative review of observational studies to summarize the available evidence of the association between T2D and cancer. To deal with the problem of abundance of published studies, we reviewed up to December 2017, the literature of meta-analyses of observational studies first, then we reviewed cohort studies not reported in meta-analyses because of more recent publication...
March 27, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29594465/interpreting-body-mri-cases-classic-findings-in-abdominal-mri
#12
REVIEW
Leann Kania, Flavius Guglielmo, Donald Mitchell
Few things in radiology are "pathognomonic" in their appearance or presentation. However, having an awareness of those findings which are specific to a certain entity is important when interpreting imaging studies. These classic findings can be identified with many imaging modalities, but no modality provides as many recognizable observations as an MRI. This results from the large variety of pulse sequences that provide high contrast resolution, prior to and following contrast administration. In this article, the most classically recognized abdominal findings are presented including the following: Liver: Cyst, hemangioma, focal nodular hyperplasia, hepatic adenoma, hemosiderosis, hepatocellular carcinoma...
March 28, 2018: Abdominal Radiology
https://www.readbyqxmd.com/read/29578186/contrast-enhanced-ultrasound-imaging-characteristics-of-malignant-transformation-of-a-localized-type-gallbladder-adenomyomatosis-a-case-report-and-literature-review
#13
Xiao-Chen Shi, Shao-Shan Tang, Wei Zhao
Gallbladder adenomyomatosis (GAM) is an acquired, reactive, tumor-like condition. Malignant transformation is extremely rare, and imaging features during contrast-enhanced ultrasound (CEUS) have not been described before. Herein, we describe a 73-year-old Asian man who had been diagnosed with gallbladder carcinoma by conventional ultrasonography (US). Based on additional radiological findings, we believed that it was a localized adenomyomatosis. However, the histopathological diagnosis was adenocarcinoma originate from adenomyomatosis with serosal invasion...
2018: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/29573316/risk-factors-of-adverse-events-in-endoscopic-retrograde-cholangiopancreatography-for-patients-aged-%C3%A2-85-years
#14
Koji Takahashi, Toshio Tsuyuguchi, Harutoshi Sugiyama, Junichiro Kumagai, Masato Nakamura, Yotaro Iino, Ayako Shingyoji, Mutsumi Yamato, Hiroshi Ohyama, Yuko Kusakabe, Shin Yasui, Rintaro Mikata, Naoya Kato
AIM: Little is known about the factors that contribute to the occurrence of adverse events in endoscopic retrograde cholangiopancreatography (ERCP) for people aged ≥85 years and safety for the super-old. Therefore, we decided to identify these factors and to examine whether ERCP is safe in the super-old. METHODS: This was a single-center retrospective study. A total of 137 patients aged ≥85 years who underwent therapeutic ERCP at Chiba University Hospital from January 2012 to March 2017 were retrospectively reviewed...
March 24, 2018: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/29569755/ldha-is-a-direct-target-of-mir-30d-5p-and-contributes-to-aggressive-progression-of-gallbladder-carcinoma
#15
Yuting He, Xiaolong Chen, Yan Yu, Juan Li, Qiuyue Hu, Chen Xue, Jianan Chen, Shen Shen, Yonggang Luo, Fang Ren, Chao Li, Jie Bao, Jingya Yan, Guowu Qian, Zhigang Ren, Ranran Sun, Guangying Cui
Gallbladder cancer (GBC) is the most general biliary tract malignancy, with poor prognosis due to rapid tumor progression and lack of specific symptoms. Lactate dehydrogenase-A (LDHA) can promote Warburg effect to produce lactate and Adenosine Triphosphate (ATP) in aerobic condition, which contributes to oncogenesis metastasis and drug resistance in various cancers. However, the expression and functional role of LDHA in GBC are largely unknown. We determined that LDHA was over-expressed in GBC tumor tissues compared with normal tissues, which was also an independent prognostic factor for the overall survival of GBC patients by tissue microarrays analysis...
March 23, 2018: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/29564177/investigation-of-targetable-predictive-and-prognostic-markers-in-gallbladder-carcinoma
#16
Azfar Neyaz, Nuzhat Husain, Sameer Gupta, Swati Kumari, Aditi Arora, Namrata Puneet Awasthi, Kiran Preet Malhotra, Sanjeev Misra
Background: Gallbladder carcinoma, uncommon in most of the world, is frequent in South East Asia. It presents in advanced stages with limited therapeutic options. We investigated targetable predictive and prognostic Markers in 268 cases including 233 primary site lesions and 35 metastatic gallbladder carcinoma. Methods: EGFR, VEGF, HER2/Neu and p53 were assessed using immunohistochemistry. HER2/Neu was validated in a subset by fluorescent in situ hybridization (FISH) using tissue microarray (TMA)...
February 2018: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/29562907/tumor-infiltrating-mast-cells-predict-prognosis-and-gemcitabine-based-adjuvant-chemotherapeutic-benefit-in-biliary-tract-cancer-patients
#17
Xiaobo Bo, Jie Wang, Tao Suo, Xiaoling Ni, Han Liu, Sheng Shen, Min Li, Yueqi Wang, Houbao Liu, Jiejie Xu
BACKGROUND: Recent studies have reported TIMs play an important role in tumors progression or regression, but the effect of TIMs in biliary tract cancer remains unclear. The aim of this study is to investigate the prognostic value of tumor infiltrating mast cells (TIMs) and its influence on gemcitabine-based adjuvant chemotherapy (ACT) benefits in biliary tract cancer patients after surgery. METHODS: TIMs were evaluated by immunohistochemical staining of tryptase in 250 patients with resected gallbladder carcinoma (GBC) or extrahepatic bile duct carcinoma (EBDC) from Zhongshan Hospital...
March 21, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29560297/harmonic-scalpel-assisted-laparoscopic-cholecystectomy-vs-conventional-laparoscopic-cholecystectomy-a-non-randomized-control-trial
#18
Kumar Rajnish, Sathasivam Sureshkumar, Manwar S Ali, Chellappa Vijayakumar, Sundaramurthi Sudharsanan, Chinnakali Palanivel
Introduction Laparoscopic cholecystectomy (LC) is the most commonly done, minimally invasive surgical procedure. Routinely used electrocautery produces more smoke, which masks the operating field, thereby prolongs the surgery and posing an increased risk of gallbladder (GB) perforation. The titanium clips used for clipping the cystic artery and cystic duct have a risk of slippage, which may lead to bleeding, and an increased risk for bile leakage. In addition, it may act as a nidus for stone formation. Advanced energy sources, such as the harmonic scalpel, though expensive, may provide the advantage of shorter operating time by reducing smoke, bloodless dissection in the GB bed, lower risk of bleeding from the cystic artery due to secure vessel sealing, and avoiding the use of a larger number of titanium clips...
January 18, 2018: Curēus
https://www.readbyqxmd.com/read/29550632/long-noncoding-rna-mincr-regulates-cellular-proliferation-migration-and-invasion-in-hepatocellular-carcinoma
#19
Jinyu Cao, Deyuan Zhang, Liangtao Zeng, Fanrong Liu
PURPOSE: Accumulating evidence indicates that long noncoding RNAs (lncRNAs) are aberrantly expressed in many cancer types, including hepatocellular carcinoma (HCC). lncRNA MYC-induced long non-coding RNA (MINCR) were revealed to be markedly up-regulated in gallbladder cancer and Burkitt lymphoma cells. However, the biological role and function of MINCR in HCC progression are still unknown. METHODS: The expression of MINCR in HCC tissues and cell lines was determined using quantitative real-time polymerase chain reaction assays...
March 15, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29549846/synchronous-gallbladder-squamous-cell-carcinoma-and-adenocarcinoma-both-as-primary-tumors-in-one-patient
#20
Amir Vahedi, Mahzad Azimpouran, Ali Ghavidel, Mahsa Karbasi, Mehrdad Farhadi
INTRODUCTION: Synchronous primary carcinomas of gallbladder are extremely rare. In this paper, we report a case of double primary carcinomas in gallbladder CASE REPORT: A 65 year old male was admitted to the hospital for surgical removal of gallbladder, which was diagnosed as cholecystitis in ultrasonography. Macroscopic examination disclosed a single whitish mass in gallbladder neck and another distinct mass in the fundus as wall thickening. Pathologic findings revealed squamous cell carcinoma of the neck and adenocarcinoma in the fundus...
March 6, 2018: International Journal of Surgery Case Reports
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