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Carcinoma of gallbladder

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https://www.readbyqxmd.com/read/28230007/laparoscopic-combined-with-percutaneous-ablation-for-hepatocellular-carcinoma-under-liver-capsule-a-single-chinese-center-experience-of-thirty-patients
#1
Zhe Tang, Yi Zhu, Kezhong Tang, Linping Dong, Bin Yang, Heqin Fang, Yulian Wu, Bo Zhang
AIM OF STUDY: For the tumor lesions close to capsule of the liver, traditional percutaneous radiofrequency ablation (PRFA) is limited due to high incidence of postoperative complications. The aim of the present study is to whether laparoscopic combined with PRFA (LCPR) could effectively ablate the tumor lesions close to capsule of the liver. METHODS: A total of 119 patients with subcapsular hepatocellular carcinoma (HCC) were divided into two groups: PRFA group (89 patients) and LCPR group (30 patients)...
December 2016: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/28222323/a-case-report-of-the-clear-cell-variant-of-gallbladder-carcinoma
#2
Ravi Maharaj, Christo Cave, Kevin Sarran, Nigel Bascombe, Dilip Dan, Wesley Greaves, Wayne A Warner
INTRODUCTION: Clear cell gallbladder carcinoma accounts for less than 1% of all gallbladder malignancies and demonstrates its unique histopathological characteristics in patients with no prior medical illness or familial predisposition. PRESENTATION OF CASE: Here we present a case of a 56-year-old female, with no prior medical conditions presented with a 2-month history of upper abdominal pain. Routine hematological and biochemical tests were unremarkable. An abdominal ultrasound revealed the presence of a gallbladder calculi, and a fundic mass while magnetic resonance cholangiopancreatography revealed a 8...
January 12, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28216422/systemic-chemotherapy-combined-with-resection-for-locally-advanced-gallbladder-carcinoma-surgical-and-survival-outcomes
#3
John M Creasy, Debra A Goldman, Vikas Dudeja, Maeve A Lowery, Andrea Cercek, Vinod P Balachandran, Peter J Allen, Ronald P DeMatteo, T Peter Kingham, Michael I D'Angelica, William R Jarnagin
BACKGROUND: Preoperative chemotherapy is a strategy for conversion to resection and/or assessing disease biology prior to operation. The utility of such an approach in gallbladder carcinoma (GBCA) is unknown. This study evaluates outcomes of GBCA patients treated with chemotherapy for locally advanced or lymph node involved tumors. STUDY DESIGN: Patients that received systemic chemotherapy for locally advanced or lymph node positive GBCA were identified from a departmental database...
February 12, 2017: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/28216138/clinicopathologic-characteristics-of-young-patients-with-gallbladder-cancer
#4
Sung-Im Do, Hyoun Wook Lee, Jin Hee Sohn, Kyungeun Kim
Gallbladder cancer is the most common biliary tract cancer and the fifth most common cancer of the digestive system. However, the clinicopathologic features of gallbladder cancer in young Korean patients have not been studied. This study included 101 consecutive cases of gallbladder cancer that underwent cholecystectomy at Kangbuk Samsung Hospital from December 1990 to March 2011. The patients were divided into two groups by age at initial diagnosis of gallbladder cancer: a young patient group aged less than 45 years and an old patient group aged 45 or older...
December 29, 2016: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28195258/linitis-plastica-like-primary-signet-ring-cell-carcinoma-of-the-gallbladder-an-extremely-rare-variant
#5
S Agarwal, P Pandey, P Durgapal, M Krishna
Signet ring carcinoma (SRCC) of gallbladder is an extremely rare tumor accounting for approximately 3% of all gallbladder carcinomas, with a handful of case reports in the literature. We report a case of signet ring cell carcinoma of the gallbladder in a 70 year-old female who was operated upon after the preoperative diagnosis of cholecystitis with cholelithiasis, based on ultrasonographic findings and subsequently diagnosed as signet ring cell carcinoma of the gallbladder on histopathological examination. Grossly there was no discrete growth, instead tumor presented as linitis plastica like diffuse thickening of the gallbladder wall...
December 2016: Pathologica
https://www.readbyqxmd.com/read/28195110/a-case-of-gallbladder-mass-malakoplakia-the-tumor-mimicker
#6
Kanwaljeet Singh, Tathagatta Chatterjee
Diagnosis of malakoplakia presenting as gall bladder mass is a diagnostic dilemma faced by pathologists, radiologists, and surgeons. Malakoplakia is a rare inflammatory disorder and tumor mimicker usually occurring in the urinary tract, may occasionally be found in gall bladder. Here, we present a rare case, presenting as gall bladder mass in a known case of gallstone disease, clinically suspected as carcinoma and later turned out to be malakoplakia in gall bladder.
January 2017: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/28178656/stathmin-decreases-cholangiocarcinoma-cell-line-sensitivity-to-staurosporine-triggered-apoptosis-via-the-induction-of-erk-and-akt-signaling
#7
Yueqi Wang, Zhihui Gao, Dexiang Zhang, Xiaobo Bo, Yaojie Wang, Jiwen Wang, Sheng Shen, Han Liu, Tao Suo, Hongtao Pan, Zhilong Ai, Houbao Liu
Cholangiocarcinoma is a rare, but highly fatal malignancy. However, the intrinsic mechanism involved in its tumorigenesis remains obscure. An urgent need remains for a promising target for cholangiocarcinoma biological therapies. Based on comparative proteomical technologies, we found 253 and 231 different spots in gallbladder tumor cell lines and cholangiocarcinoma cell lines, respectively, relative to non-malignant cells. Using Mass Spectrometry (MS) and database searching, we chose seven differentially expressed proteins...
February 2, 2017: Oncotarget
https://www.readbyqxmd.com/read/28178615/long-non-coding-rna-tug1-promotes-cell-proliferation-and-metastasis-by-negatively-regulating-mir-300-in-gallbladder-carcinoma
#8
Fei Ma, Shou-Hua Wang, Qiang Cai, Long-Yang Jin, Di Zhou, Jun Ding, Zhi-Wei Quan
BACKGROUND: As we all know, long non-coding RNAs (lncRNAs) have been reported to play vital roles in various human cancers. In this study, we aimed to explore the role of lncRNA TUG1 in gallbladder carcinoma (GBC) development. METHODS: Total RNA was extracted from the tissues of thirty GBC patients, four GBC cell lines. We detected the expression levels of TUG1 using quantitative real-time PCR. We performed CCK8, colony formation, transwell invasion and apoptosis assays to study the effects of TUG1 on GBC cell proliferation and invasion...
February 5, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28163293/a-case-of-poorly-differentiated-mucinous-carcinoma-of-the-gallbladder-that-exhibited-a-peculiar-morphology
#9
Takahiro Urata, Michiko Nagamine, Naotaka Kugiyama, Kana Noda, Ryo Ichikawa, Masataka Takeguchi, Kazuhito Yoshimoto, Nobuhiro Minami, Hideki Kitada, Yoshi Takekuma
A 65-year-old female presented with an elevated lesion that was identified in the gallbladder fundus via abdominal ultrasound during a medical checkup. The tumor was a pedunculated lesion, measuring 30mm in diameter, that exhibited a blood flow pattern with gradual dense staining throughout the equilibrium phase on the abdominal contrast computed tomography and a high signal intensity on T2-weighted magnetic resonance imaging. Histopathological findings revealed the proliferation of poorly differentiated adenocarcinoma, including signet ring cells, throughout the tumor along with the formation of a mucous lake...
2017: Nihon Shokakibyo Gakkai Zasshi, the Japanese Journal of Gastro-enterology
https://www.readbyqxmd.com/read/28133236/-a-case-of-gallbladder-carcinoma-and-breast-cancer-associated-with-pancreaticobiliary-maljunction
#10
Takeshi Hijikawa, Hiroaki Kitade, Hidesuke Yanagida, Masanori Yamada, Noriko Sueoka, Aiko Ueda, Yu Tsubota, Daigo Yamamoto, Kazuhiko Yoshioka, Masanori Kon
We report a case of gallbladder cancer and right breast cancer associated with pancreaticobiliary maljunction.The patient was a 74-year-old woman who presented with abdominal pain due to cholecystitis.Abdominal CT detected a gallbladder tumor and right breast tumor.Enhanced CT and MRCP examination revealed gallbladder cancer and right breast cancer associated with pancreaticobiliary maljunction.We performed a gallbladder bed resection, bile duct resection, and right total mastectomy.The histopathological diagnosis of the gallbladder was moderately tubular adenocarcinoma and that of the breast tumor was scirrhous carcinoma...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28133193/-a-case-of-adenocarcinoma-of-the-vater-papilla-treated-with-pancreatoduodenectomy-after-hepaticojejunostomy-for-prior-adenocarcinoma-of-the-gallbladder
#11
Yu Takeda, Yoshito Tomimaru, Kozo Noguchi, Hirotsugu Nagase, Atsushi Hamabe, Masashi Hirota, Kazuteru Oshima, Tsukasa Tanida, Tomono Kawase, Shunji Morita, Hiroshi Imamura, Takashi Iwazawa, Kenzo Akagi, Shiro Adachi, Keizo Dono
A 77-year-old man was diagnosed with acute cholecystitis and underwent laparoscopic cholecystectomy. Since adenocarcinoma in the gallbladder was detected by histopathological examination, he received additional resection for the carcinoma: partial hepatectomy(S4a, S5), extrahepatic bile duct resection, and hepaticojejunostomy. Five years after the surgery, he was diagnosed with adenocarcinoma of the Vater papilla. Pancreatoduodenectomy was performed. During the surgery, the prior hepaticojejunostomy and jejunojejunostomy were preserved, and the gastrointestinal tract was cut at the stomach and jejunum 5 cm from the Treitz ligament...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28132788/prognostic-heterogeneity-of-the-seventh-edition-of-uicc-stage-iii-gallbladder-carcinoma-which-patients-benefit-from-surgical-resection
#12
J Sakata, T Kobayashi, T Ohashi, Y Hirose, K Takano, K Takizawa, K Miura, H Ishikawa, K Toge, K Yuza, D Soma, T Ando, T Wakai
BACKGROUND: This study sought to evaluate the prognostic heterogeneity of Stage III (Union for International Cancer Control, seventh edition) gallbladder carcinoma. METHODS: Of 175 patients enrolled with gallbladder carcinoma who underwent radical resection, 22 were classified with Stage IIIA disease (T3N0M0) and 46 with Stage IIIB disease (T2N1M0 [n = 23] and T3N1M0 [n = 23]). The median number of retrieved lymph nodes per patient was 18. RESULTS: This staging system failed to stratify outcomes between Stages IIIA and IIIB; survival after resection was better for patients with Stage IIIB disease than for patients with Stage IIIA disease, with 5-year survival of 54...
January 19, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28118609/the-clinical-value-of-lncrna-neat1-in-digestive-system-malignancies-a-comprehensive-investigation-based-on-57-microarray-and-rna-seq-datasets
#13
Dan-Dan Xiong, Zhen-Bo Feng, Wei-Luan Cen, Jing-Jing Zeng, Lu Liang, Rui-Xue Tang, Xiao-Ning Gan, Hai-Wei Liang, Zu-Yun Li, Gang Chen, Dian-Zhong Luo
This comprehensive investigation was performed to evaluate the expression level and potential clinical value of NEAT1 in digestive system malignancies. A total of 57 lncRNA datasets of microarray or RNA-seq and 5 publications were included. The pooled standard mean deviation (SMD) indicated that NEAT1 was down-regulated in esophageal carcinoma (ESCA, SMD = -0.35, 95% CI: -0.5~-0.20, P < 0.0001) and hepatocellular carcinoma (HCC, SMD = -0.47, 95% CI: -0.60~-0.34, P < 0.0001), while in pancreatic cancer (PC), NEAT1 was up-regulated (SMD = 0...
January 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/28109315/evaluation-of-surgical-treatment-for-incidental-gallbladder-carcinoma-diagnosed-during-or-after-laparoscopic-cholecystectomy-single-center-results
#14
Masashi Utsumi, Hideki Aoki, Tomoyoshi Kunitomo, Yutaka Mushiake, Isao Yasuhara, Takashi Arata, Koh Katsuda, Kohji Tanakaya, Hitoshi Takeuchi
BACKGROUND: Laparoscopic cholecystectomy (LC) is the accepted standard management for benign gallbladder disease. LC rarely results in a diagnosis of incidental gallbladder carcinoma (IGBC). The aim of our study was to report our experience with IGBC diagnosed during or following LC. METHODS: Between January 2008 and January 2015, 352 patients underwent LC at Iwakuni Clinical Center. Among these patients, 8 (2.3%) were diagnosed with IGBC. We evaluated their characteristics, surgical related variables, histopathological findings and surgical outcomes...
January 21, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28105553/does-ca-19-9-have-prognostic-relevance-in-gallbladder-carcinoma-gbc
#15
Sushma Agrawal, Able Lawrence, Rajan Saxena
BACKGROUND: There is a scarce data on prognostic relevance of carbohydrate antigen (CA 19-9). This retrospective study was undertaken to evaluate its prognostic relevance in different prognostic subsets of gallbladder carcinoma (GBC). MATERIALS AND METHODS: One hundred forty-one patients of GBC treated between January 2012 and December 2014 were the subjects of this retrospective analysis. Baseline CA 19-9 levels of four cohorts of patients: extended cholecystectomy (EC), simple cholecystectomy (SC) with residual or recurrent disease, locally advanced disease (LAGBC) and metastatic disease were ascertained...
January 20, 2017: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/28105220/overexpression-of-thy1-and-itga6-is-associated-with-invasion-metastasis-and-poor-prognosis-in-human-gallbladder-carcinoma
#16
Dan-Hua Zhang, Zhu-Lin Yang, En-Xiang Zhou, Xiong-Ying Miao, Qiong Zou, Jing-He Li, Lu-Feng Liang, Gui-Xiang Zeng, Sen-Lin Chen
Gallbladder cancer (GBC) is a rare but highly aggressive cancer for which no well-accepted prognostic biomarkers have been identified. Thymus cell antigen 1 (Thy1), also known as cluster of differentiation (CD)90, and integrin α6 (ITGA6), also known as CD49f, are important molecules in cancer and putative markers of various stem cell types. However, their role in GBC remains to be elucidated. In the present study, Thy1 and ITGA6 expression status in clinical GBC samples, which comprised squamous cell/adenosquamous carcinoma (SC/ASC) and adenocarcinoma (AC) subtypes, was investigated...
December 2016: Oncology Letters
https://www.readbyqxmd.com/read/28104035/-application-value-of-laparoscopic-radiofrequency-ablation-for-specific-location-hepatocellular-carcinoma
#17
H D Shi, X J Shi, H X Ma, Y R Liang, L Zhou, Y Shi
Objective: To investigate the therapeutic efficacy and safety of laparoscopic radiofrequency ablation (LRFA) for specific-location hepatocellular carcinoma. Methods: To retrospectively analyze 496 patients with specific-location hepatocellular carcinoma treated with LRFA from January 2010 to January 2015 in our hospital. There was a total of 652 hepatic lesions with a mean diameter of (2.8±1.3) cm including 397 cases with single lesion and 99 cases with multiple lesions. The hepatic lesions were adjacent to major hepatic vessels, hepatic hilar region, diaphragmatic dome, gallbladder, or gastrointestinal tract and on the surface of the liver, respectively...
January 23, 2017: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://www.readbyqxmd.com/read/28103928/primary-carcinoma-of-the-cystic-duct-a-case-report-and-review-of-classifications
#18
Lovenish Bains, Daljit Kaur, Arun Kumar Kakar, Aman Batish, Seema Rao
BACKGROUND: The incidence of extrahepatic bile duct malignancies is about 2-3.6% of all gastrointestinal malignancies. Primary carcinoma of cystic duct is a rare condition comprising a fraction of all extrahepatic bile duct malignancies with less than 70 cases reported worldwide. Majority of these cases were reported from East Asia. There is paucity in such case being reported from Indian subcontinent. We present a case of primary carcinoma of the cystic duct encountered during laparoscopic cholecystectomy...
January 19, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28101681/extended-liver-venous-deprivation-before-major-hepatectomy-induces-marked-and-very-rapid-increase-in-future-liver-remnant-function
#19
Boris Guiu, François Quenet, Laure Escal, Frédéric Bibeau, Lauranne Piron, Philippe Rouanet, Jean-Michel Fabre, Eric Jacquet, Alban Denys, Pierre-Olivier Kotzki, Daniel Verzilli, Emmanuel Deshayes
OBJECTIVE: The aim of this study was to assess the safety and efficacy of extended liver venous deprivation (eLVD), i.e. combination of right portal vein embolisation and right (accessory right) and middle hepatic vein embolisation before major hepatectomy for future remnant liver (FRL) functional increase. METHODS: eLVD was performed in non-cirrhotic patients referred for major hepatectomy in a context of small FRL (baseline FRL <25% of the total liver volume or FRL function <2...
January 18, 2017: European Radiology
https://www.readbyqxmd.com/read/28101355/undifferentiated-carcinoma-of-the-gallbladder-with-endothelial-differentiation-a-case-report-and-literature-review
#20
Yoshitaka Furuya, Kenzo Hiroshima, Takashi Wakahara, Harutoshi Akimoto, Hironobu Yanagie, Kenichi Harigaya, Hiroshi Yasuhara
Undifferentiated carcinoma of the gallbladder is a rare cancer type with a poor prognosis. The present study described a case of undifferentiated gallbladder carcinoma of the spindle- and giant-cell type, according to the 2010 World Health Organization classification. Hematoxylin and eosin staining revealed that the tumor consisted of dense interlacing bundles of spindle-shaped cells. No evidence of cartilaginous, osseous or rhabdomyosarcomatous differentiation was observed. Immunohistochemical staining revealed that spindle- and polygonal-shaped cells of the undifferentiated carcinoma were positive for cytokeratin AE1/3, vimentin and vascular endothelial growth factor...
December 2016: Molecular and Clinical Oncology
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