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Neutrophil and lymphocyte ratio

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https://www.readbyqxmd.com/read/28528087/prognostic-value-of-inflammatory-and-nutritional-scores-in-renal-cell-carcinoma-after-nephrectomy
#1
Ding Peng, Zhi-Song He, Xue-Song Li, Qi Tang, Lei Zhang, Kai-Wei Yang, Xiao-Teng Yu, Cui-Jian Zhang, Li-Qun Zhou
INTRODUCTION: We compared the prognostic significance of inflammatory and nutritional scores, including the prognostic nutritional index (PNI), neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and lymphocyte-to-monocyte ratio in patients with renal cell carcinoma (RCC) undergoing nephrectomy. PATIENTS AND METHODS: We retrospectively analyzed the data from 1360 patients with RCC undergoing nephrectomy from 2001 to 2010. The PNI was calculated as the serum albumin level (g/L) + 5 × lymphocyte count (10(9)/L)...
April 27, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28522249/peripheral-differentials-by-cytodiff-flow-cytometric-system-predict-disease-activity-in-chinese-patients-with-inflammatory-bowel-disease
#2
Shulan Zhang, Ziyan Wu, Ji Li, Xiaoting Wen, Liubing Li, Chenxi Liu, Fengchun Zhang, Jiaming Qian, Yongzhe Li
BACKGROUND: This study aimed at evaluating whether leukocyte differentials could serve as effective biomarkers for disease activity in IBD. METHODS: A total of 100 subjects were prospectively enrolled, including 36 patients with CD, 34 patients with UC, and 30 healthy controls (HC). Leukocyte differentials were determined by CytoDiff Flow Cytometry analysis. RESULTS: Total neutrophil counts, monocyte/lymphocyte ratio (M/L), and CD16(-) monocyte/lymphocyte ratio (CD16(-) M/L) were significantly higher in active UC patients compared with quiescent UC patients and HC...
May 15, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28520670/neutrophil-to-lymphocyte-ratio-as-a-novel-predictor-of-outcome-in-patients-with-severe-traumatic-brain-injury
#3
Weiqiang Chen, Jinhua Yang, Bingbing Li, Guoyi Peng, Tianfei Li, Lianjie Li, Shousen Wang
OBJECTIVE: The neutrophil to lymphocyte ratio (NLR) has been reported to be a predictor of outcome in critical illness. Objective of this study was to investigate the changes of the NLR in patients with severe traumatic brain injury (TBI) and analyze the relationship between the NLR and TBI outcome. SETTING: China. PARTICIPANTS: A total of 855 patients with severe TBI from January 2007 to April 2012. DESIGN: Retrospective...
May 17, 2017: Journal of Head Trauma Rehabilitation
https://www.readbyqxmd.com/read/28516153/neutrophil-to-lymphocyte-ratio-nlr-at-the-time-of-transurethral-resection-of-bladder-tumor-a-large-retrospective-study-and-analysis-of-racial-differences
#4
Ngii N Tazeh, Daniel J Canter, Shivashankar Damodaran, Timothy Rushmer, Kyle A Richards, E Jason Abel, David F Jarrard, Tracy M Downs
Introduction: Neutrophil/lymphocyte ratio (NLR) is an indicator of systemic inflammation and has been proven to be associated with an increased risk of extravesical disease, decreased cancer specific survival and overall survival in bladder cancer patients. A large proportion of healthy African Americans have a WBC count that is persistently lower than the normal range defined for individuals of European ancestry, this condition has been called "benign ethnic neutropenia". The purpose of our study was to determine if NLR was different in patients of African ancestry (AA) vs European ancestry (EA) across different tumor grades and stages at the time of transurethral resection of bladder tumor(s) (TURBT)...
April 27, 2017: Bladder Cancer
https://www.readbyqxmd.com/read/28514738/prognostic-value-of-neutrophil-to-lymphocyte-ratio-in-urothelial-carcinoma-of-the-upper-urinary-tract-and-bladder-a-systematic-review-and-meta-analysis
#5
Xintao Li, Xin Ma, Lu Tang, Baojun Wang, Luyao Chen, Fan Zhang, Xu Zhang
The neutrophil-to-lymphocyte ratio (NLR) is an inflammation marker that has prognostic value for various tumors, but its prognostic value in urothelial carcinoma (UC) remains controversial. This meta-analysis investigated the prognostic value of NLR in UC. A systematic search was performed on PubMed, ISI Web of Science, and Embase for studies focusing on the association between NLR and clinical features or prognosis of UC and published until November 2016. Prognostic outcomes and clinical features were collected and analyzed...
April 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/28509396/anti-inflammatory-antioxidant-and-immunomodulatory-effects-of-curcumin-in-ovalbumin-sensitized-rat
#6
Farzaneh Shakeri, Mohammad Hossein Boskabady
BACKGROUND: Anti-inflammatory and antioxidant properties of curcumin have been shown. In this study, anti-inflammatory, antioxidant, and immunomodulatory effects of curcumin in sensitized rat were evaluated. METHODS: Six groups of rats including control (C), ovalbumin-sensitized (as a rat model of asthma, S), S groups treated with curcumin (Cu 0.15, 0.30, and 0.60 mg/mL), and 1.25 μg/mL dexamethasone (S + D) were studied. Curcumin and dexamethasone were given in animals' drinking water during sensitization period...
May 16, 2017: BioFactors
https://www.readbyqxmd.com/read/28505894/re-the-prognostic-significance-of-the-early-postoperative-neutrophil-to-lymphocyte-ratio-in-patients-with-urothelial-carcinoma%C3%A2-of%C3%A2-the%C3%A2-bladder-undergoing-radical-cystectomy
#7
https://www.readbyqxmd.com/read/28503236/impact-of-neutrophil-to-lymphocyte-ratio-on-effects-of-targeted-therapy-for-metastatic-renal-cell-carcinoma-patients-with-extrapulmonary-metastasis
#8
Jun Teishima, Shinya Ohara, Kousuke Sadahide, Shinsuke Fujii, Hiroyuki Kitano, Kohei Kobatake, Shunsuke Shinmei, Keisuke Hieda, Shogo Inoue, Tetsutaro Hayashi, Koji Mita, Akio Matsubara
INTRODUCTION: The aim of our present study was to investigate the impact of the pretreatment neutrophil-to-lymphocyte ratio (NLR) on the antitumour effects of targeted agents in patients with metastatic renal cell carcinoma (mRCC). METHODS: The NLRs in 283 cases of molecular targeted therapy for mRCC were measured before starting the prescription of the molecular targeted agent. The significance of pretreatment NLR on the site of metastatic organs and on progression-free survival (PFS) in each case was analyzed...
May 2017: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/28503068/a-retrospective-study-on-the-prognostic-value-of-preoperative-neutrophil-lymphocyte-ratio-in-patients-with-primary-small-cell-carcinoma-of-the-esophagus
#9
Yan Wang, Jun Feng Liu
INTRODUCTION: There is increasing evidence that systemic inflammation influences the prognosis in patients with malignant tumors. The aim of this research was to investigate the prognostic value of neutrophil/lymphocyte ratio (NLR) in patients with primary small-cell carcinoma of the esophagus. METHODS: This study retrospectively analyzed 129 patients with primary small-cell carcinoma of the esophagus who underwent esophagectomy in The Fourth Hospital of Hebei Medical University between January 2008 and December 2010...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28502119/neutrophil-to-lymphocyte-ratio-decreases-after-treatment-of-psoriasis-with-therapeutic-antibodies
#10
L Zhang, C Wiles, L R Martinez, G Han
Although neutrophils are a histologic hallmark of psoriasis, it is unclear whether neutrophils are simply effector cells or drive pathogenesis. A recent psoriasis study with murine models evaluated various chemokines, lipids, and cytokines proposing that neutrophils are key players in positive feedback loops perpetuating the disease.(1) Additionally, when neutrophils are depleted in pustular psoriasis, the disease drastically improves.(2) There is mounting evidence supporting the use of neutrophil to lymphocyte ratio (NLR) as a marker of inflammation in active psoriasis...
May 14, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28500616/significance-of-blood-neutrophil-to-lymphocyte-ratio-for-prognostic-stratification-of-patients-with-gastroesophageal-junction-adenocarcinoma-in-the-era-of-the-8th-edition-of-the-american-joint-committee-on-cancer-ajcc8-staging
#11
Alicia-Marie Conway, Zena Salih, George Papaxoinis, Kimberly Fletcher, Jamie Weaver, Ana Patrao, Robert Noble, Sofia Stamatopoulou, Vikki Owen-Holt, Wasat Mansoor
The prognosis of patients with gastroesophageal junction (GOJ) adenocarcinoma depends mainly on the clinical staging, as described by the new AJCC8 (American Joint Committee on Cancer 8th edition). Evidence suggests that peripheral blood neutrophil-to-lymphocyte ratio (NLR) may be of prognostic significance in patients with upper gastrointestinal cancers. We examined the prognostic significance of NLR in the era of the new AJCC8 staging system. In this single-centre cohort study, retrospective data on patients with operable GOJ adenocarcinoma treated with perioperative chemotherapy were analysed...
June 2017: Medical Oncology
https://www.readbyqxmd.com/read/28498842/prognostic-significance-and-predictors-of-the-system-inflammation-score-in-ovarian-clear-cell-carcinoma
#12
Hongwei Zhang, Jiaqi Lu, Yingying Lu, Jiayi Zhou, Zehua Wang, Haiou Liu, Congjian Xu
Chronic inflammation is a well-known epidemiologic factor of ovarian clear cell carcinomas (OCCC), but has an uncertain role in prognosis. We developed a systemic inflammation score (SIS) based on preoperative serum albumin and neutrophil-to-lymphocyte ratio (NLR) for predicting progression-free survival (PFS) and overall survival (OS) in OCCC patients. A retrospective review was performed in 155 patients with OCCC undergoing primary debulking and chemotherapy at a single institute between 1995 and 2010. Cox regression models were fitted to analyze the effect of prognostic factors on PFS and OS...
2017: PloS One
https://www.readbyqxmd.com/read/28497933/scalp-block-for-glioblastoma-surgery-is-associated-with-lower-inflammatory-scores-and-improved-survival
#13
Lan Zheng, Katherine B Hagan, John Villarreal, Visesh Keerty, Jasper Chen, Juan P Cata
BACKGROUND: Regional anesthesia has anti-inflammatory effects. Recent studies suggest that regional anesthesia might improve the survival of patients with cancer. We hypothesized that the use of a scalp block (SB) during craniotomy for glioblastoma (GB) decreases the postoperative systemic and local inflammatory response and extend their survival. METHODS: This retrospective study included 119 patients with GB who underwent tumor resection. We divided patients into 2 groups based on the use of SB during surgery...
May 12, 2017: Minerva Anestesiologica
https://www.readbyqxmd.com/read/28497463/can-haematologic-parameters-be-used-for-differential-diagnosis-of-testicular-torsion-and-epididymitis
#14
A Bitkin, M Aydın, B C Özgür, L Irkilata, E Akgunes, Mevlut Keles, H Sarıcı, M K Atilla
A differential diagnosis of testicular torsion and epididymitis has serious importance for testicular health. In emergency conditions, if testicular torsion goes unnoticed and epididymo-orchitis is diagnosed, organ loss may occur. This study aimed to evaluate the usefulness of haematologic parameters for the diagnosis of both testicular torsion and epididymo-orchitis and for differential diagnosis of these two diseases. Patients were divided into three groups as those undergoing surgery for testicular torsion, those receiving medical treatment for epididymitis and a healthy control group...
May 12, 2017: Andrologia
https://www.readbyqxmd.com/read/28496093/prediction-of-new-onset-and-recurrent-atrial-fibrillation-by-complete-blood-count-tests-a-comprehensive-systematic-review-with-meta-analysis
#15
Alexander Weymann, Sadeq Ali-Hasan-Al-Saegh, Anton Sabashnikov, Aron-Frederik Popov, Seyed Jalil Mirhosseini, Tong Liu, Mohammadreza Lotfaliani, Michel Pompeu Barros de Oliveira Sá, William L L Baker, Senol Yavuz, Mohamed Zeriouh, Jae-Sik Jang, Hamidreza Dehghan, Lei Meng, Luca Testa, Fabrizio D'Ascenzo, Umberto Benedetto, Gary Tse, Luis Nombela-Franco, Pascal M Dohmen, Abhishek J Deshmukh, Cecilia Linde, Giuseppe Biondi-Zoccai, Gregg W Stone, Hugh Calkins, Integrated Meta-Analysis Of Cardiac Surgery And Cardiology-Group Imcsc-Group
BACKGROUND Atrial fibrillation (AF) is one of the most critical and frequent arrhythmias precipitating morbidities and mortalities. The complete blood count (CBC) test is an important blood test in clinical practice and is routinely used in the workup of cardiovascular diseases. This systematic review with meta-analysis aimed to determine the strength of evidence for evaluating the association of hematological parameters in the CBC test with new-onset and recurrent AF. MATERIAL AND METHODS We conducted a meta-analysis of observational studies evaluating hematologic parameters in patients with new-onset AF and recurrent AF...
May 12, 2017: Medical Science Monitor Basic Research
https://www.readbyqxmd.com/read/28493493/neutrophil-lymphocyte-ratio-platelet-lymphocyte-ratio-and-mean-platelet-volume-in-japanese-patients-with-psoriasis-and-psoriatic-arthritis-response-to-therapy-with-biologics
#16
Akihiko Asahina, Naoko Kubo, Yoshinori Umezawa, Hiromi Honda, Koichi Yanaba, Hidemi Nakagawa
Recent studies indicate the presence of systemic inflammation in psoriatic patients, and this inflammatory status is significantly associated with a range of comorbidities. The aim of this study was to evaluate the clinical significance of novel inflammatory biomarkers, neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR) and mean platelet volume (MPV) in Japanese patients with plaque-type psoriasis (PsV) and psoriatic arthritis (PsA). One hundred and eighty-six patients with PsV and 50 patients with PsA treated with biologics, including infliximab, adalimumab and ustekinumab, were retrospectively analyzed before and after treatment...
May 11, 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/28491087/neutrophil-to-lymphocyte-ratio-compared-to-n-terminal-pro-brain-natriuretic-peptide-as-a-prognostic-marker-of-adverse-events-in-elderly-patients-with-chronic-heart-failure
#17
Wei Yan, Rui-Jun Li, Qian Jia, Yang Mu, Chun-Lei Liu, Kun-Lun He
BACKGROUND: The neutrophil-to-lymphocyte (N/L) ratio has been associated with poor prognosis in patients with heart failure, but it has not been compared with N-terminal pro-brain natriuretic peptide (NT-proBNP) in elderly patients with chronic heart failure (CHF). We sought to make this comparison. METHODS: A total of 1355 elderly patients with CHF were analyzed. A multivariate logistic regression model was used to analyze the variables associated with atrial fibrillation (AF)...
February 2017: Journal of Geriatric Cardiology: JGC
https://www.readbyqxmd.com/read/28490331/quantifying-capture-stress-in-free-ranging-european-roe-deer-capreolus-capreolus
#18
Nikolaus Huber, Sebastian G Vetter, Alina L Evans, Petter Kjellander, Susanne Küker, Ulrika A Bergvall, Jon M Arnemo
BACKGROUND: To understand and reduce the concomitant effects of trapping and handling procedures in wildlife species, it is essential to measure their physiological impact. Here, we examined individual variation in stress levels in non-anesthetized European roe deer (Capreolus capreolus), which were captured in box traps and physically restrained for tagging, biometrics and bio-sampling. In winter 2013, we collected venous blood samples from 28 individuals during 28 capture events and evaluated standard measurements for stress (heart rate, body temperature, neutrophil to lymphocyte ratio, lactate and total cortisol)...
May 10, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28489884/comparison-of-the-prognostic-values-of-preoperative-inflammation-based-parameters-in-patients-with-breast-cancer
#19
Hideya Takeuchi, Hirohumi Kawanaka, Seiichi Fukuyama, Nobuhide Kubo, Shoji Hiroshige, Tokujiro Yano
Peripheral blood-derived inflammation-based markers, including C-reactive protein (CRP), neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte ratio (LMR), and platelet-to-lymphocyte ratio (PLR) are indicators of prognosis in various malignant tumors. The present study aimed to identify the inflammation-based parameters that are most suitable for predicting outcomes in patients with breast cancer. Two hundred ninety-six patients who underwent surgery for localized breast cancer were reviewed retrospectively...
2017: PloS One
https://www.readbyqxmd.com/read/28489790/ca125-modified-by-plt-and-nlr-improves-the-predictive-accuracy-of-adenomyosis-derived-pelvic-dense-adhesion
#20
Caixia Jiang, Chao Liu, Jing Guo, Li Chen, Ning Luo, Xiaoyan Qu, Weihong Yang, Qing Ren, Zhongping Cheng
To explore the value of serum levels of CA125, platelet count (PLT), neutrophil-lymphocyte ratio (NLR), and modified CA125 markers CA125a and CA125b in predicting pelvic dense adhesion (PDA) associated with adenomyosis, CA125a = lg(CA125 × PLT × 10), CA125b = lg(CA125 × NLR).This retrospective study included 304 patients who underwent surgery for adenomyosis. Correlations of serum levels of CA125, PLT, NLR, and modified CA125 markers with adenomyosis-derived PDA were analyzed by Logistic regression...
May 2017: Medicine (Baltimore)
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