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Neutrophil and lymphocyte ratio

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https://www.readbyqxmd.com/read/28938679/association-of-immunologic-markers-from-complete-blood-counts-with-the-response-to-preoperative-chemoradiotherapy-and-prognosis-in-locally-advanced-rectal-cancer
#1
Sung Woo Jung, In Ja Park, Se Heon Oh, Seung-Seop Yeom, Jong Lyul Lee, Yong Sik Yoon, Chan Wook Kim, Seok-Byung Lim, Jung Bok Lee, Chang Sik Yu, Jin Cheon Kim
We investigated retrospectively whether immunologic markers from a complete blood count (CBC) are associated with the responsiveness to preoperative chemoradiotherapy (PCRT) and oncologic outcomes in 984 patients with locally advanced rectal cancer (LARC) who also underwent radical surgery from 2005 to 2013. CBC parameters including the neutrophil to lymphocyte ratio (NLR), lymphocyte to monocyte ratio (LMR), and platelet to lymphocyte ratio (PLR) were recorded. Pathologic responses to PCRT were evaluated in the resected specimens using the tumor regression grade system...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28938630/prognostic-role-of-neutrophil-lymphocyte-ratio-in-patients-with-glioma
#2
Jing Zhang, Sunfu Zhang, Yanlin Song, Min He, Qingqing Ren, Chaoyue Chen, Zhiyong Liu, Yunhui Zeng, Jianguo Xu
The purpose of this study was to evaluate the prognostic role of neutrophil lymphocyte ratio (NLR) in patients with glioma. PubMed, EMBASE, Cochrane Library and China National Knowledge Infrastructure were searched for relevant literature. The study and patient characteristics were extracted. Hazard ratios (HRs) with 95% confidence intervals (CIs) were pooled to estimate the prognostic role of NLR in patients with glioma. Subgroup analysis and sensitivity analysis were also performed. Six studies with 1,021 patients were included...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28938543/predictive-clinical-model-of-tumor-response-after-chemoradiation-in-rectal-cancer
#3
Marisa D Santos, Cristina Silva, Anabela Rocha, Carlos Nogueira, Fernando Castro-Poças, António Araujo, Eduarda Matos, Carina Pereira, Rui Medeiros, Carlos Lopes
Survival improvement in rectal cancer treated with neoadjuvant chemoradiotherapy (nCRT) is achieved only if pathological response occurs. Mandard tumor regression grade (TRG) proved to be a valid system to measure nCRT response. The ability to predict tumor response before treatment may significantly have impact the selection of patients for nCRT in rectal cancer. The aim is to identify potential predictive pretreatment factors for Mandard response and build a clinical predictive model design. 167 patients with locally advanced rectal cancer were treated with nCRT and curative surgery...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28936913/evaluation-of-complete-blood-count-indices-nlr-plr-mpv-plt-and-plcri-in-healthy-dogs-dogs-with-periodontitis-and-dogs-with-oropharyngeal-tumors-as-potential-biomarkers-of-systemic-inflammatory-response
#4
Ana Rejec, Janos Butinar, Jerzy Gawor, Milan Petelin
The aim of the study was to retrospectively assess complete blood count (CBC) indices of dogs with periodontitis (PD; n = 73) and dogs with oropharyngeal tumors (OT; n = 92) in comparison to CBC indices of healthy dogs (HD; n = 71). Neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio, mean platelet volume to platelet ratio, and platelet large cell ratio index (PLCRi) were evaluated as biomarkers of systemic inflammatory response provoked by PD and OT. Results of multivariable polytomous logistic regression analysis indicated no significant associations between CBC indices and PD...
January 1, 2017: Journal of Veterinary Dentistry
https://www.readbyqxmd.com/read/28930918/neutrophil-to-lymphocyte-ratio-predicts-death-in-acute-on-chronic-liver-failure-patients-admitted-to-the-intensive-care-unit-a-retrospective-cohort-study
#5
Nicolas Moreau, Xavier Wittebole, Yvan Fleury, Patrice Forget, Pierre-François Laterre, Castanares-Zapatero Diego
The neutrophil-to-lymphocyte ratio (NLR) is an inflammation score recognized as associated with outcome. While inflammation has been shown to correlate with the development of acute-on-chronic liver failure (ACLF), we sought to investigate the role of NLR in predicting 90-day mortality in cirrhotic patients experiencing ACLF.We performed a retrospective cohort study involving a total of 108 consecutive cirrhotic patients admitted in the intensive care unit (ICU). NLR, clinical and biological data were recorded...
September 19, 2017: Shock
https://www.readbyqxmd.com/read/28929777/is-it-possible-to-predict-the-presence-of-colorectal-cancer-in-a-blood-test-a-probabilistic-approach-method
#6
José Manuel Navarro Rodríguez, Javier Gallego Plazas, Rafael Calpena Rico, Fernando Borras Rocher, José Antonio Ruiz Macia, Miguel Ángel Morcillo Ródenas
INTRODUCTION: The assessment of the state of immunosurveillance (the ability of the organism to prevent the development of neoplasias) in the blood has prognostic implications of interest in colorectal cancer. We evaluated and quantified a possible predictive character of the disease in a blood test using a mathematical interaction index of several blood parameters. The predictive capacity of the index to detect colorectal cancer was also assessed. METHODS: We performed a retrospective case-control study of a comparative analysis of the distribution of blood parameters in 266 patients with colorectal cancer and 266 healthy patients during the period from 2009 to 2013...
September 18, 2017: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/28929423/oxidative-stress-in-inflammatory-cells-of-patient-with-rheumatoid-arthritis-clinical-efficacy-of-dietary-antioxidants
#7
REVIEW
Asis Bala, Chaitali Mondal, Pallab Kanti Haldar, Bidita Khandelwal
Rheumatoid arthritis (RA) is an autoimmune disease responsible for significant human morbidity in modern life. However, oxidative stress is one of the key markers for determining pathophysiology of patients with RA. The interaction between cellular immune system and body's endogenous and/or exogenous antigens produce reactive oxygen species (ROS) and reactive nitrogen species (RNS) in autoimmune disease like RA. ROS and RNS include highly toxic superoxide (O2(-)) and peroxynitrite (ONOO(-)) radicals, which activate the signaling cascades of inflammatory cells to synthesize pro-inflammatory cytokines and chemokines...
September 19, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/28918424/systemic-inflammatory-response-is-a-prognostic-marker-in-hiv-infected-patients-with-hepatocellular-carcinoma
#8
David J Pinato, Marco Merli, Alessia Dalla Pria, Shiraz Jamshaid, Kizzy Parker, Nicole Pagani, Hamid Hasson, Caterina Uberti Foppa, Emanuela Messina, Rohini Sharma, Mark Nelson, Mark Bower
BACKGROUND: Hepatocellular carcinoma (HCC) is increasingly prevalent in people living with HIV. Systemic inflammation is a prognostic factor requiring validation in HIV-associated HCC. AIMS: Using a multi-centre database of consecutive HCC cases, we investigated the prognostic role of a panel of inflammatory markers, including neutrophil to lymphocyte ratio (NLR), using univariate and multivariate survival analyses. RESULTS: Fifty-nine patients with HIV-associated HCC secondary to hepatitis C (69%) or B virus infection (32%) were identified...
September 16, 2017: Oncology
https://www.readbyqxmd.com/read/28916967/combined-analysis-of-the-pre-and-postoperative-neutrophil-lymphocyte-ratio-predicts-the-outcomes-of-patients-with-gastric-cancer
#9
Kozo Miyatani, Hiroaki Saito, Yusuke Kono, Yuki Murakami, Hirohiko Kuroda, Tomoyuki Matsunaga, Yoji Fukumoto, Tomohiro Osaki, Keigo Ashida, Yoshiyuki Fujiwara
PURPOSE: The neutrophil-lymphocyte ratio (NLR) is a biochemical marker of the systemic inflammatory response and has been associated with prognosis for various types of cancer. This retrospective study investigates the relationship between the pre- and postoperative NLR and the prognosis of gastric cancer patients. METHODS: The subjects were 280 patients who underwent curative surgery for histopathologically diagnosed gastric adenocarcinoma. RESULTS: The preoperative NLR was significantly correlated with tumor size, tumor depth, lymphatic invasion, venous invasion, and disease stage...
September 15, 2017: Surgery Today
https://www.readbyqxmd.com/read/28915691/preoperative-monocyte-lymphocyte-and-neutrophil-lymphocyte-but-not-platelet-lymphocyte-ratios-are-predictive-of-clinical-outcomes-in-resected-patients-with-non-metastatic-siewert-type-ii-iii-adenocarcinoma-of-esophagogastric-junction-a-prospective-cohort-study
#10
Jia-Wei Zhang, Lei Huang, A-Man Xu
AIMS: To propectively reveal the clinicopathological and prognostic significances of monocyte-lymphocyte ratio (MLR), neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) in resected patients with non-metastatic Siewert type II/III adenocarcinoma of esophagogastric junction (AEG). METHODS: A total of 611 patients diagnosed with Siewert type II/III AEG and undergoing surgery between 2006 and 2011 were prospectively followed-up until April 2016. Associations between preoperative peripheral MLR, NLR, and PLR and clinicopathological parameters were quantified using the multivariate Logistic regression model with adjustment...
August 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28915688/neutrophil-to-lymphocyte-ratio-and-neurological-deterioration-following-acute-cerebral-hemorrhage
#11
Simona Lattanzi, Claudia Cagnetti, Leandro Provinciali, Mauro Silvestrini
Immunity plays key roles in pathophysiology of intracerebral hemorrhage (ICH). The aim of the study was to determine whether the peripheral leukocyte count and neutrophil-to-lymphocyte ratio (NLR) predicted neurological deterioration (ND) after ICH. We identified consecutive patients with ICH who had blood sampling performed within 24 hours from symptom's onset. Total white blood cells (WBC), absolute neutrophil count (ANC) and absolute lymphocyte count (ALC) were retrieved, and the NLR computed as the ratio of the ANC to ALC values...
August 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28915685/prognostic-significance-of-neutrophil-to-lymphocyte-ratio-in-patients-with-malignant-pleural-mesothelioma-a-meta-analysis
#12
Nan Chen, Shuai Liu, Lin Huang, Wanling Li, Wenhao Yang, Tianxin Cong, Lin Ding, Meng Qiu
Systemic inflammation responses can be reflected by peripheral blood count and combine index like the neutrophil-to-lymphocyte (NLR). The NLR has been reported to be a poor prognostic indicator in cancer recently. However, the prognostic effect of the NLR in patients with malignant pleural mesothelioma (MPM) still unclear yet. We conducted this meta-analysis aiming to evaluate the pooled value of NLR in prognosis as well as clinical characteristics in malignant pleural mesothelioma. A total of 11 studies with 1533 patients were included in this meta-analysis, in which 10 studies investigated the prognosis role of NLR using hazard ratio (HR) and 95% confidence intervals (95% CI)...
August 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28912780/inflammatory-markers-for-arterial-stiffness-in-cardiovascular-diseases
#13
REVIEW
Ioana Mozos, Clemens Malainer, Jarosław Horbańczuk, Cristina Gug, Dana Stoian, Constantin Tudor Luca, Atanas G Atanasov
Arterial stiffness predicts an increased risk of cardiovascular events. Inflammation plays a major role in large arteries stiffening, related to atherosclerosis, arteriosclerosis, endothelial dysfunction, smooth muscle cell migration, vascular calcification, increased activity of metalloproteinases, extracellular matrix degradation, oxidative stress, elastolysis, and degradation of collagen. The present paper reviews main mechanisms explaining the crosstalk between inflammation and arterial stiffness and the most common inflammatory markers associated with increased arterial stiffness, considering the most recent clinical and experimental studies...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28910561/assessment-of-neutrophil-to-lymphocyte-ratio-and-platelet-to-lymphocyte-ratio-in-patients-with-dry-eye-disease
#14
Tuba Celik
PURPOSE: To evaluate the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) levels in patients with dry eye disease (DED). METHODS: The white blood cell, neutrophil, platelet, and lymphocyte counts were performed in 78 dry eye patients and 60 controls. The NLR was calculated by dividing neutrophil count by lymphocyte count and the PLR was calculated by dividing platelet count by lymphocyte count. RESULTS: The mean age was 53...
September 14, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/28910242/how-does-the-social-get-under-the-gums-the-role-of-socio-economic-position-in-the-oral-systemic-health-link
#15
Noha Gomaa, Belinda Nicolau, Arjumand Siddiqi, Howard Tenenbaum, Michael Glogauer, Carlos Quiñonez
OBJECTIVES: To evaluate the extent of association between systemic inflammation and periodontal disease in American adults, and to assess whether socio-economic position mediated this relationship. METHODS: We used data from the National Health and Nutrition Examination Survey (NHANES IV) (2001-2010). Systemic inflammation was defined by individual and aggregate (cumulative inflammatory load) biomarkers (C-reactive protein, white blood cell counts, neutrophil counts, and neutrophil:lymphocyte ratio)...
September 14, 2017: Canadian Journal of Public Health. Revue Canadienne de Santé Publique
https://www.readbyqxmd.com/read/28910195/elevated-neutrophil-to-lymphocyte-ratio-in-metabolic-syndrome-is-associated-with-increased-risk-of-colorectal-adenoma
#16
Jae Hyun Kim, Kyoung Im Cho, Young A Kim, Seun Ja Park
BACKGROUND: Metabolic syndrome (MetS) is an important cardiovascular risk factor for insulin resistance and has been linked to colorectal adenoma via inflammation. The neutrophil-to-lymphocyte ratio (NLR) has been suggested as an important inflammatory marker. We initiated this investigation to determine the relationship between colorectal adenoma and NLR in patients with MetS. METHODS: We examined participants who visited the Health Promotion Center at Kosin University Gospel Hospital, Busan, Korea...
September 14, 2017: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/28906371/survival-prediction-model-for-postoperative-hepatocellular-carcinoma-patients
#17
Zhihui Ren, Shasha He, Xiaotang Fan, Fangping He, Wei Sang, Yongxing Bao, Weixin Ren, Jinming Zhao, Xuewen Ji, Hao Wen
This study is to establish a predictive index (PI) model of 5-year survival rate for patients with hepatocellular carcinoma (HCC) after radical resection and to evaluate its prediction sensitivity, specificity, and accuracy.Patients underwent HCC surgical resection were enrolled and randomly divided into prediction model group (101 patients) and model evaluation group (100 patients). Cox regression model was used for univariate and multivariate survival analysis. A PI model was established based on multivariate analysis and receiver operating characteristic (ROC) curve was drawn accordingly...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28905815/psa-time-to-nadir-as-a-prognostic-factor-of-first-line-docetaxel-treatment-in-castration-resistant-prostate-cancer-evidence-from-patients-in-northwestern-china
#18
Kai-Jie Wu, Xin-Qi Pei, Ge Tian, Da-Peng Wu, Jin-Hai Fan, Yu-Mei Jiang, Da-Lin He
Docetaxel-based chemotherapy remains the first-line treatment for patients with metastatic castration-resistant prostate cancer (mCRPC) in China; however, the prognostic factors associated with effects in these patients are still controversial. In this study, we retrospectively reviewed the data from 71 eligible Chinese patients who received docetaxel chemotherapy from 2009 to 2016 in our hospital and experienced a reduction of prostate-specific antigen (PSA) level ≥50% during the treatment and investigated the potential role of time to nadir (TTN) of PSA...
September 12, 2017: Asian Journal of Andrology
https://www.readbyqxmd.com/read/28902640/is-neutrophyl-to-lymphocyte-ratio-really-a-useful-marker-for-all-grades-of-degenerative-aortic-stenosis
#19
Selçuk Küçükseymen, Göksel Çağırcı, Ramazan Güven, Şakir Arslan
OBJECTIVE: Inflammatory processes play an important role in cardiac valve calcification and ossification. The aim of this study was to investigate the relationship between the neutrophil-lymphocyte ratio (NLR) and degenerative aortic stenosis (AS). METHODS: A total of 220 patients with AS and 158 healthy individuals who were a control group were included in the study. The NLR was calculated by dividing the number of neutrophils by number of lymphocytes in peripheral blood samples...
September 2017: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
https://www.readbyqxmd.com/read/28900989/-clinicopathological-classification-and-prognostic-factors-of-gastrointestinal-neuroendocrine-neoplasms-an-analysis-of-119-cases
#20
Xinli Ma, Wenyi Zhao, Chun Zhuang, Xiaosong Wang, Lin Tu, Ming Wang, Yongwei Sun, Hui Cao
OBJECTIVE: To investigate the clinical characteristics, pathological classification and prognostic factors of gastrointestinal neuroendocrine neoplasms (GI-NENs). METHODS: Clinicopathological data of 119 GI-NENs patients at Shanghai Renji Hospital from November 2007 to December 2016 were analyzed retrospectively. According to the classification and grading criteria of the WHO Neuroendocrine Tumor 2010 edition, patients were classified pathologically to realize the malignant degree of tumors...
September 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
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