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Neutrophil and lymphocyte ratio

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https://www.readbyqxmd.com/read/28811954/is-neutrophil-to-lymphocyte-ratio-a-predictor-of-coronary-artery-disease-in-western-indians
#1
Kamal Sharma, Alap K Patel, Komal H Shah, Ashwati Konat
INTRODUCTION: The current study was designed to evaluate the association of neutrophil-to-lymphocyte ratio (NLR) with coronary artery disease (CAD) presence. We also aimed to propose a suitable cut-off of NLR for diagnosis of CAD in Western Indians. METHODS: Total 324 patients undergoing coronary angiography were enrolled and were subdivided into two groups: group 1 (n = 99; population without CAD) and group 2 (n = 225; population with CAD). RESULTS: The results indicated significant (p < 0...
2017: International Journal of Inflammation
https://www.readbyqxmd.com/read/28811903/value-of-neutrophil-to-lymphocyte-ratio-for-predicting-lung-cancer-prognosis-a-meta-analysis-of-7-219-patients
#2
Yu Yu, Lei Qian, Jiuwei Cui
Current evidence suggests that the neutrophil-to-lymphocyte ratio (NLR) may be a biomarker for poor prognosis in lung cancer, although this association remains controversial. Therefore, a meta-analysis was performed to evaluate the association between NLR and lung cancer outcome. A systematic literature search was performed through the PubMed, Embase and Cochrane Library databases (until July 30, 2016), to identify studies evaluating the association between NLR and overall survival (OS) and/or progression-free survival (PFS) among patients with lung cancer...
September 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28810877/neutrophils-in-cancer-prognostic-role-and-therapeutic-strategies
#3
REVIEW
Alberto Ocana, Cristina Nieto-Jiménez, Atanasio Pandiella, Arnoud J Templeton
Expression of high levels of immune cells including neutrophils has been associated with detrimental outcome in several solid tumors and new strategies to decrease their presence and activity are currently under clinical development. Here, we review some of the relevant literature of the role of neutrophils in different stages of the oncogenic process including tumor initiation, growth, proliferation or metastatic spreading and also focus on how neutrophil counts or the neutrophil-to-lymphocyte ratio may be used as a prognostic and predictive biomarker...
August 15, 2017: Molecular Cancer
https://www.readbyqxmd.com/read/28808503/prognostic-efficacy-of-inflammation-based-markers-in-patients-with-curative-colorectal-cancer-resection
#4
Özgür Akgül, Erdinç Çetinkaya, Metin Yalaza, Sabri Özden, Mesut Tez
AIM: To evaluate the prognostic significance of neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR), and prognostic nutritional index (PNI) and other clinicopathological factors in patients undergoing curative resection of colon cancer. METHODS: 183 patients with histologically proven colorectal cancer who had undergone potentially curative resection between 2010 and 2016 at Ankara Numune Training and Research Hospital were retrospectively analyzed and clinicopathological characteristics included age, sex, tumor type, grade, size and localization, the number of metastatic and total number of lymph nodes removed, vascular and perineural invasion of the tumor, TNM stages, tumor marker levels (CEA, CA19-9, AFP, CA-125, CA15-3), complete blood counts, albumin levels, overall survival (months), NLR, PLR, LMR and PNI ratios were retrospectively reviewed and analyzed from the electronic database...
July 15, 2017: World Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28807718/autonomic-regulation-of-systemic-inflammation-in-humans-a-multi-center-blinded-observational-cohort-study
#5
Gareth L Ackland, Gary Minto, Martin Clark, John Whittle, Robert Cm Stephens, Thomas Owen, Pradeep Prabhu, Ana Gutierrez Del Arroyo
OBJECTIVE: Experimental animal models demonstrate that autonomic activity regulates systemic inflammation. By contrast, human studies are limited in number and exclusively use heart rate variability (HRV) as an index of cardiac autonomic regulation. HRV measures are primarily dependent on, and need to be corrected for, heart rate. Thus, independent autonomic measures are required to confirm HRV-based findings. Here, the authors sought to replicate the findings of preceding HRV-based studies by using HRV-independent, exercise-evoked sympathetic and parasympathetic measures of cardiac autonomic regulation to examine the relationship between autonomic function and systemic inflammation...
August 11, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28801777/an-internally-validated-new-clinical-and-inflammation-based-prognostic-score-for-patients-with-advanced-hepatocellular-carcinoma-treated-with-sorafenib
#6
R Diaz-Beveridge, G Bruixola, D Lorente, J Caballero, E Rodrigo, Á Segura, D Akhoundova, A Giménez, J Aparicio
BACKGROUND: Sorafenib is a standard treatment for patients (pts) with advanced hepatocellular carcinoma (aHCC), although the clinical benefit is heterogeneous between different pts groups. Among novel prognostic factors, a low baseline neutrophil-to-lymphocyte ratio (bNLR) and early-onset diarrhoea have been linked with a better prognosis. PURPOSE: To identify prognostic factors in pts with aHCC treated with 1st-line sorafenib and to develop a new prognostic score to guide management...
August 11, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28800269/the-connections-among-suicidal-behavior-lipid-profile-and-low-grade-inflammation-in-patients-with-major-depressive-disorder-a-specific-relationship-with-the-neutrophil-to-lymphocyte-ratio
#7
Okan Ekinci, Asli Ekinci
OBJECTIVES: The role of inflammation and lipid metabolism in the pathophysiology of suicidal behavior has received particular attention in recent years. The neutrophil-to-lymphocyte ratio (NLR) has been suggested as a new and more reliable indicator of low-grade inflammation. NLR has been found to be altered in major depressive disorder (MDD) and has been related to various factors, including chronic stress and impulsivity that were previously reported to be related to suicidal behavior...
August 11, 2017: Nordic Journal of Psychiatry
https://www.readbyqxmd.com/read/28799624/neutrophil-to-lymphocyte-ratio-as-prognostic-indicator-for-patients-with-esophageal-squamous-cell-cancer
#8
Guo-Dong Gao, Bo Sun, Xian-Bin Wang, Shi-Meng Wang
BACKGROUND: This study aimed to evaluate the correlation between neutrophil to lymphocyte ratio (NLR) with overall survival (OS) of esophageal squamous cell carcinoma (ESCC) patients. METHOD: Records of patients with diagnosed ESCC were reviewed. Leukocyte counts and patients' characteristics were extracted from their clinical records to calculate NLR. Correlation between NLR and baseline characteristics with overall survival (OS) was then analyzed using Cox regression...
August 7, 2017: International Journal of Biological Markers
https://www.readbyqxmd.com/read/28798770/diagnostic-value-of-neutrophil-to-lymphocyte-ratio-and-platelet-to-lymphocyte-ratio-in-crohn-s-disease
#9
Jue-Rong Feng, Xiao Qiu, Fan Wang, Peng-Fei Chen, Qian Gao, Ya-Nan Peng, Xue Lin, Qing Liu, Jing Liu, Qiu Zhao, Jin Li
The aim of this study is to investigate the diagnostic efficacy of neutrophil-to-lymphocyte ratio (NLR), neutrophil-to-monocyte ratio (NMR), lymphocyte-to-monocyte ratio (LMR), and platelet-to-lymphocyte ratio (PLR) in patients with Crohn's disease (CD) and non-CD controls. These ratios were all derived from complete blood counts. Two hundred and six participants including CD inpatients and non-CD controls were retrospectively enrolled. We found statistically higher NLR and PLR and lower LMR in CD patients than in non-CD controls (all P < 0...
2017: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/28796857/association-of-systemic-inflammation-and-sarcopenia-with-survival-in-nonmetastatic-colorectal-cancer-results-from-the-c-scans-study
#10
Elizabeth M Cespedes Feliciano, Candyce H Kroenke, Jeffrey A Meyerhardt, Carla M Prado, Patrick T Bradshaw, Marilyn L Kwan, Jingjie Xiao, Stacey Alexeeff, Douglas Corley, Erin Weltzien, Adrienne L Castillo, Bette J Caan
Importance: Systemic inflammation and sarcopenia are easily evaluated, predict mortality in many cancers, and are potentially modifiable. The combination of inflammation and sarcopenia may be able to identify patients with early-stage colorectal cancer (CRC) with poor prognosis. Objective: To examine associations of prediagnostic systemic inflammation with at-diagnosis sarcopenia, and determine whether these factors interact to predict CRC survival, adjusting for age, ethnicity, sex, body mass index, stage, and cancer site...
August 10, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28795308/the-mean-corpuscular-volume-as-a-prognostic-factor-for-colorectal-cancer
#11
Hidemasa Nagai, Norihiro Yuasa, Eiji Takeuchi, Hideo Miyake, Yuichiro Yoshioka, Kanji Miyata
PURPOSE: The aim of the present study was to identify the factors investigated during routine blood examinations which can predict the disease outcome independent of the tumor stage. METHODS: Data from 1174 patients with stage I, II, and III CRC who underwent R0 resection were included. We investigated the correlations between the preoperative routine blood examination data, and clinicopathological factors, and disease-free survival (DFS) using univariate and multivariate analyses...
August 9, 2017: Surgery Today
https://www.readbyqxmd.com/read/28794643/preoperative-lymphocyte-to-monocyte-ratio-represents-a-superior-predictor-compared-with-neutrophil-to-lymphocyte-and-platelet-to-lymphocyte-ratios-for-colorectal-liver-only-metastases-survival
#12
Jianhong Peng, Hui Li, Qingjian Ou, Junzhong Lin, Xiaojun Wu, Zhenhai Lu, Yunfei Yuan, Desen Wan, Yujing Fang, Zhizhong Pan
Systemic inflammation was recognized as an essential factor contributing to the development of malignancies. This study aimed to investigate the prognostic value of pre-operative lymphocyte-to-monocyte ratio (LMR), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) in patients with colorectal liver-only metastases (CLOM) undergoing hepatectomy. We retrospectively enrolled 150 consecutive patients with CLOM between 2000 and 2012. The optimal cutoff values of continuous LMR, NLR, and PLR were determined using the receiver operating characteristic curve analysis...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28792143/significance-of-neutrophil-to-lymphocyte-ratio-as-a-novel-indicator-of-spontaneous-ureter-stone-passage
#13
Kwang Suk Lee, Jee Soo Ha, Kyo Chul Koo
PURPOSE: Stone size and location are generally considered the most important factors associated with spontaneous ureter stone passage (SSP). Several parameters related to inflammatory changes have been identified as predictors associated with SSP. Our aim was to investigate the predictive role of neutrophil-to-lymphocyte ratio (NLR) for SSP. MATERIALS AND METHODS: A retrospective review was performed on 131 patients who were referred to the urology outpatient clinic and diagnosed with unilateral ureteral stones at our emergency department between July 2016 and December 2016...
September 2017: Yonsei Medical Journal
https://www.readbyqxmd.com/read/28778099/predictive-clinical-model-of-tumor-response-after-chemoradiation-in-rectal-cancer
#14
Marisa D Santos, Cristina Silva, Anabela Rocha, Carlos Nogueira, Fernando Castro-Poças, António Araujo, Eduarda Matos, Carina Pereira, Rui Medeiros, Carlos Lopes
Survival improvement in rectal cancer treated with neoadjuvant chemoradiotherapy (nCRT) is achieved only if pathological response occurs. Mandard tumor regression grade (TRG) proved to be a valid system to measure nCRT response. The ability to predict tumor response before treatment may significantly have impact the selection of patients for nCRT in rectal cancer. The aim is to identify potential predictive pretreatment factors for Mandard response and build a clinical predictive model design. 167 patients with locally advanced rectal cancer were treated with nCRT and curative surgery...
July 28, 2017: Oncotarget
https://www.readbyqxmd.com/read/28772242/the-relationship-between-the-welfare-quality-and-stress-index-in-working-and-breeding-horses
#15
Silvana Popescu, Eva A Diugan
The aim of this observational study was to investigate if a relationship exists between the calculated overall individual welfare score (as an indicator of the welfare quality) and the neutrophil:lymphocyte (N:L) ratio (as a stress indicator) in working (draught) and reproduction horses (breeding stallions and broodmares), in two different seasons. The welfare of the horses was assessed by a protocol which included health and behavioural parameters. An individual welfare score was computed, the total and differential WBC count was established and the N:L ratio was calculated for each of the 1482 assessed horses...
July 26, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/28769565/can-we-use-the-neutrophil-to-lymphocyte-ratio-platelet-to-lymphocyte-ratio-and-mean-platelet-volume-values-for-the-diagnosis-of-anterior-uveitis-in-patients-with-behcet-s-disease
#16
Atil Avci, Deniz Avci, Fatma Erden, Ertas Ragip, Ali Cetinkaya, Kemal Ozyurt, Mustafa Atasoy
INTRODUCTION: The purpose of this study was to compare the value of hematological parameters, neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and mean platelet volume (MPV), as indicators of anterior uveal segment involvement in patients with Behcet's disease (BD). PATIENTS AND METHODS: Hospital-based records of a total of 912 patients with BD from the dermatology clinic and healthy volunteers from the checkup clinic were assessed retrospectively...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/28769556/increased-neutrophil-lymphocyte-ratio-in-delirium-a-pilot-study
#17
Angelique Egberts, Francesco Us Mattace-Raso
AIM: Delirium is a common and severe complication among older hospitalized patients. The pathophysiology is poorly understood, but it has been suggested that inflammation and oxidative stress may play a role. The aim of this pilot study was to investigate levels of the neutrophil-lymphocyte ratio (NLR) - a marker of systemic inflammation and oxidative stress - in patients with and without delirium. METHODS: This pilot study was performed within a retrospective chart review study that included acutely ill patients, 65 years and older, who were admitted to the ward of geriatrics of the Erasmus University Medical Center...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/28769542/relationship-of-mean-platelet-volume-to-mdd-a-retrospective-study
#18
Liqiang Cai, Luoyi Xu, Lili Wei, Wei Chen
BACKGROUND: Results of numerous studies show that major depressive disorder (MDD) is associated with a chronic low-grade inflammation, but the underlying mechanism remains unclear. AIM: To compare the results of blood cell analysis of MDD patients with healthy controls, and explore the potential value of it as an indicator of immune-inflammation in MDD, especially the mean platelet volume. METHODS: 103 MDD patients and 106 healthy controls with matched age and gender were recruited...
February 25, 2017: Shanghai Archives of Psychiatry
https://www.readbyqxmd.com/read/28766758/comparisons-of-neutrophil-monocyte-eosinophil-and-basophil-lymphocyte-ratios-among-various-systemic-autoimmune-rheumatic-diseases
#19
Zaixing Yang, Zhiyu Zhang, Feng Lin, Yingpeng Ren, Donghong Liu, Renqian Zhong, Yan Liang
This study was aimed to evaluate levels of neutrophil- (NLR), monocyte- (MLR), eosinophil- (ELR), and basophil-lymphocyte ratio (BLR) and their association with inflammatory markers in systemic autoimmune rheumatic diseases (SARDs). A total of 1139 SARD patients and 170 healthy individuals were enrolled. Clinical and laboratory data were extracted. NLR and MLR were significantly increased, but BLR decreased in most SARD patients (p < 0.05). ELR were significantly decreased in systemic lupus erythematosus (SLE) patients, but increased in those with other SARDs (p < 0...
August 2, 2017: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/28766520/-the-peculiarities-of-the-relationship-between-the-effector-cells-of-the-local-immune-system-in-the-broncho-vascular-barrier-of-the-breast-fed-infants-presenting-with-certain-acute-respiratory-viral-infections
#20
O D Yagmurov, S N Litus
The acute respiratory viral infections (ARVI) are ranked among the most widespread diseases affecting the children in the early infancy. They account for 60 to 85.4% of all infections recorded in the young children. AIM: The objective of the present study was to elucidate the peculiar features of the accumulation of the effector cells of the local immunity system and intercellular interplay in the broncho-vascular barrier of the breast-fed infants presenting with various ARVIs. MATERIAL AND METHODS: We undertook the analysis of 32 cases of infections caused by influenza A and B viruses and of the adenovirus infection verified by the immunofluorescence assay...
2017: Sudebno-meditsinskaia Ekspertiza
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