keyword
https://read.qxmd.com/read/38537235/relation-between-neutrophil-to-lymphocyte-ratio-with-epidural-analgesia-timing-and-thoracotomy-pain
#1
JOURNAL ARTICLE
Taha Semerci, Ersagun Tugcugil, Ahmet Besir
OBJECTIVE: This study investigated the relationship of the pre-operative neutrophil/lymphocyte ratio (NLR) to the timing of epidural analgesia administration and post-operative acute and chronic pain in thoracotomy. MATERIALS AND METHODS: The study was conducted on 60 patients, with NLR ≥ 2 (Group A) and NLR < 2 (Group B). Each group was divided into subgroups pre-emptive analgesia (Group P) and control group (Group C). Epidural analgesic solution was administered as a bolus before the surgical incision in Group P and at the end of the operation in Group C...
2024: Cirugia y Cirujanos
https://read.qxmd.com/read/38536706/prognostic-value-of-pretreatment-procalcitonin-and-neutrophil-lymphocyte-ratio-in-extensive-stage-small-cell-lung-cancer
#2
JOURNAL ARTICLE
Dongfang Chen, Jianlin Xu, Yizhuo Zhao, Baohui Han, Runbo Zhong
BACKGROUND: To investigate the influence of pretreatment neutrophil-to-lymphocyte ratio (NLR) and procalcitonin (PCT) on progression-free survival (PFS) in extensive-stage small-cell lung cancer (SCLC) patients. METHOD: A total of 100 extensive-stage SCLC patients were enrolled in our study. Patients were stratified according to the median values of pretreatment NLR and PCT levels: low NLR group (NLR ≤3.17), high NLR group (NLR>3.17), low PCT group (PCT ≤0...
December 31, 2024: Cancer Biology & Therapy
https://read.qxmd.com/read/38535095/exploring-the-correlation-between-systemic-inflammatory-markers-and-carotid-atherosclerosis-indices-in-middle-aged-adults-a-cross-sectional-study
#3
JOURNAL ARTICLE
Ji-Eun Song, Ji-In Hwang, Hae-Jin Ko, Ji-Yeon Park, Hee-Eun Hong, A-Sol Kim
BACKGROUND: This study investigated the association between atherosclerosis and systemic inflammation markers, specifically the C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR), in healthy middle-aged adults. METHODS: A retrospective cross-sectional study was conducted on a total of 1264 Korean adults aged 40-65. We assessed these inflammatory markers and carotid metrics, such as carotid intima-media thickness (cIMT), plaque number (PN), plaque stenosis score (PSS), and plaque score (PS), using linear regression, logistic regression, and receiver operating characteristic analysis...
February 21, 2024: Journal of Cardiovascular Development and Disease
https://read.qxmd.com/read/38535054/pan-immune-inflammation-value-could-be-a-new-marker-to-predict-amyloidosis-and-disease-severity-in-familial-mediterranean-fever
#4
JOURNAL ARTICLE
Tuğba Ocak, Ahmet Görünen, Belkıs Nihan Coşkun, Burcu Yağız, Sebnem Ozemri Sağ, Gökhan Ocakoğlu, Ediz Dalkılıç, Yavuz Pehlivan
Familial Mediterranean fever (FMF) is characterized by recurrent episodes of fever and serositis. Blood-based biomarkers determined in FMF patients during attack-free periods could be used to predict the risk of amyloidosis and the severity of the disease. The recently defined pan-immune-inflammation value (PIV) comprises four distinct subsets of blood cells and serves as an easily accessible and cost-effective marker. The objective of this study was to assess the role of PIV in predicting amyloidosis and moderate-to-severe disease...
March 16, 2024: Diagnostics
https://read.qxmd.com/read/38534755/increased-apolipoprotein-a1-expression-correlates-with-tumor-associated-neutrophils-and-t-lymphocytes-in-upper-tract-urothelial-carcinoma
#5
JOURNAL ARTICLE
Chih-Chia Chang, Chia-Bin Chang, Chiung-Ju Chen, Chun-Liang Tung, Chi-Feng Hung, Wei-Hong Lai, Cheng-Huang Shen, Chang-Yu Tsai, Ya-Yan Lai, Ming-Yang Lee, Shu-Fen Wu, Pi-Che Chen
An increased neutrophil-to-lymphocyte ratio (NLR) is a poor prognostic biomarker in various types of cancer, because it reflects the inhibition of lymphocytes in the circulation and tumors. In urologic cancers, upper tract urothelial carcinoma (UTUC) is known for its aggressive features and lack of T cell infiltration; however, the association between neutrophils and suppressed T lymphocytes in UTUC is largely unknown. In this study, we examined the relationship between UTUC-derived factors and tumor-associated neutrophils or T lymphocytes...
March 7, 2024: Current Issues in Molecular Biology
https://read.qxmd.com/read/38533452/plant-toll-interleukin-1-receptor-resistance-protein-domains-physically-associate-with-enhanced-disease-susceptibility1-family-proteins-in-immune-signaling
#6
JOURNAL ARTICLE
Jian Chen, Xiaoxiao Zhang, Maud Bernoux, John P Rathjen, Peter N Dodds
Plant Toll/interleukin-1 receptor/resistance protein (TIR) type nucleotide-binding and leucine-rich repeat immune receptors (NLRs) require enhanced disease susceptibility 1 (EDS1) family proteins and the helper NLRs NRG1 and ADR1 for immune activation. We show that the Nb EDS1- Nb SAG101b- Nb NRG1 signaling pathway in N. benthamiana is necessary for cell death signaling by TIR-NLRs from a range of plant species, suggesting a universal requirement for this module in TIR-NLR-mediated cell death in N. benthamiana...
February 16, 2024: IScience
https://read.qxmd.com/read/38532550/evaluation-of-tadalafil-supplementation-on-the-neutrophil-lymphocyte-and-the-platelet-lymphocyte-ratios-in-patients-with-erectile-dysfunction-a-prospective-study
#7
JOURNAL ARTICLE
Sameh Fayek GamalEl Din, Nashaat Nabil Ismail, Hanan Hosni Moawad, Iten Mohamed Adel, Ahmad Motawi, Hisham Foaad
OBJECTIVES: We aimed to evaluate the effect of daily 5 mg tadalafil on the neutrophil/lymphocyte ratio (NLR) and the platelet/lymphocyte ratio (PLR) in patients with erectile dysfunction (ED). PATIENTS AND METHODS: 30 subjects with ED were given tadalafil as well as 30 subjects with ED who were not receiving tadalafil were recruited. 30 healthy individuals served as controls. RESULTS: Receiver operating characteristic curve (ROC) showed that the best cut off point of pre-treatment and post treatment NLR in the ED treatment group was found <1...
March 26, 2024: Urologia
https://read.qxmd.com/read/38532054/atp-releasing-channels-and-the-ameliorative-effects-of-high-intensity-interval-training-on-diabetic-heart-a-multifaceted-analysis
#8
JOURNAL ARTICLE
Siyavash Joukar, Mohammad Amin Rajizadeh, Mohammad Abbas Bejeshk, Samaneh Sadat Alavi, Fatemeh Bagheri, Mohammad Rami, Kayvan Khoramipour
Type 2 diabetes (T2D) can cause severe cardiac complications at functional, histologic and molecular levels. These pathological complications could be mediated by ATP-releasing channels such as Panx1 and ATP receptors, in particular P2X7. The aim of our study was to investigate the effect of high-intensity interval training (HIIT) on T2D-induced cardiac complications at the functional, histopathological and molecular levels, with a particular focus on ATP-releasing channels. 48 male Wistar rats at the age of 8 weeks were randomly allocated into four groups: control (Con), Diabetes (T2D), Training (TR), and Diabetes + Training (T2D + TR)...
March 26, 2024: Scientific Reports
https://read.qxmd.com/read/38529588/correlation-of-neutrophil-lymphocyte-and-albumin-globulin-ratios-with-outcomes-in-patients-with-breast-cancer-undergoing-neoadjuvant-chemotherapy-or-upfront-surgery
#9
JOURNAL ARTICLE
Shi Hui Yang, Min Li Tey, Siqin Zhou, Phyu Nitar, Hanis Mariyah, Yirong Sim, Grace Kusumawidjaja, Wen Yee Chay, Wong Fuh Yong, Ru Xin Wong
PURPOSE: Higher neutrophil-lymphocyte ratio (NLRs) indicate a pro-inflammatory state and are associated with poor survival. Conversely, higher albumin-globulin ratio (AGRs) may be associated with improved prognosis. We aimed to investigate the association between NLR and AGR and prognosis and survival in patients with breast cancer. METHODS: This retrospective study included all patients with stage I-III breast cancer between 2011 and 2017 in Singapore General Hospital and National Cancer Center Singapore...
February 22, 2024: Journal of Breast Cancer
https://read.qxmd.com/read/38528483/correlation-between-insulin-resistance-and-the-rate-of-neutrophils-lymphocytes-monocytes-lymphocytes-platelets-lymphocytes-in-type-2-diabetic-patients
#10
JOURNAL ARTICLE
Yuanyuan Zhang, Huaizhen Liu
BACKGROUND: Insulin resistance (IR) was a prominent feature commonly observed in individuals with type 2 diabetes mellitus (T2DM). T2DM Individuals often exhibited a concomitant presence of low-grade chronic inflammation. In this study conducted retrospectively, the aim was to investigate the connection between neutrophils-lymphocytes rate (NLR), monocytes-lymphocytes rate (MLR), platelets-lymphocytes rate (PLR) and IR, specifically among individuals with T2DM. METHOD: This study encompassed a cohort of 405 individuals diagnosed with T2DM, comprising cases from January 2021 to November 2022...
March 25, 2024: BMC Endocrine Disorders
https://read.qxmd.com/read/38527502/-clinical-characteristics-of-hospitalized-children-with-respiratory-syncytial-virus-infection-and-risk-prediction-of-severe-illness-during-the-post-covid-19-era-in-kunming
#11
JOURNAL ARTICLE
H F Liu, Q L Feng, R W Huang, T Y Yuan, M Z Sui, P L Li, K Liu, F Li, Y Li, L Jiang, H M Fu
Objective: To compare the epidemiological and clinical characteristics of hospitalized children with respiratory syncytial virus (RSV) infection in Kunming among the pre-and post-COVID-19 era, and to establish a prediction model for severe RSV infection in children during the post-COVID-19 period. Methods: This was a retrospective study. Clinical and laboratory data were collected from 959 children hospitalized with RSV infection in the Department of Pulmonary and Critical Care Medicine at Kunming Children's Hospital during January to December 2019 and January to December 2023...
March 25, 2024: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://read.qxmd.com/read/38527048/the-relationship-between-a-series-of-inflammatory-markers-on-the-risk-of-heart-failure-in-different-gender-groups-analysis-from-nhanes-2015-2018
#12
JOURNAL ARTICLE
Ting Cheng, Dongdong Yu, Xingying Qiu, Wenwei OuYang, Geng Li, Li Zhou, Zehuai Wen
BACKGROUND: A better understanding of the level-grade inflammation for the development and worsening of heart failure (HF) in different gender groups is an unmet need. We performed an updated analysis on the impact of a series of systemic inflammation markers on HF. METHODS: This compensatory cross-sectional study enrolled participants from the National Health and Nutrition Examination Survey (NHANES) 2015-2018. HF was based on the self-reported questions. Univariate and multivariate logistic regression were used to investigate the association between systemic immune-inflammation index (SII), high sensitivity C-reactive protein (hs-CRP), lymphocyte-to-monocyte ratio (LMR), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and HF...
2024: PloS One
https://read.qxmd.com/read/38526596/diagnostic-value-of-dual-source-dual-energy-computed-tomography-combined-with-the-neutrophil-lymphocyte-ratio-for-discriminating-gastric-signet-ring-cell-from-mixed-signet-ring-cell-and-non-signet-ring-cell-carcinomas
#13
JOURNAL ARTICLE
Qinxia Song, Xiangfa Wang, Juan Zhu, Hengfeng Shi
PURPOSE: To explore the diagnostic value of dual-source computed tomography (DSCT) and neutrophil to lymphocyte ratio (NLR) for differentiating gastric signet ring cell carcinoma (SRC) from mixed SRC (mSRC) and non-SRC (nSRC). METHODS: This retrospective study included patients with gastric adenocarcinoma who underwent DSCT between August 2019 and June 2021 at our Hospital. The iodine concentration in the venous phase (ICvp ), standardized iodine concentration (NICVP ), and the slope of the energy spectrum curve (kVP ) were extracted from DSCT data...
March 25, 2024: Abdominal Radiology
https://read.qxmd.com/read/38526344/a-genome-sequence-for-the-threatened-whitebark-pine
#14
JOURNAL ARTICLE
David B Neale, Aleksey V Zimin, Amy Meltzer, Akriti Bhattarai, Maurice Amee, Laura Figueroa Corona, Brian J Allen, Daniela Puiu, Jessica Wright, Amanda R De La Torre, Patrick E McGuire, Winston Timp, Steven L Salzberg, Jill L Wegrzyn
Whitebark pine (WBP, Pinus albicaulis) is a white pine of subalpine regions in western contiguous US and Canada. WBP has become critically threatened throughout a significant part of its natural range due to mortality from the introduced fungal pathogen white pine blister rust (WPBR, Cronartium ribicola) and additional threats from mountain pine beetle (Dendroctonus ponderosae), wildfire, and maladaptation due to changing climate. Vast acreages of WBP have suffered nearly complete mortality. Genomic technologies can contribute to a faster, more cost-effective approach to the traditional practices of identifying disease-resistant, climate-adapted seed sources for restoration...
March 25, 2024: G3: Genes—Genomes—Genetics
https://read.qxmd.com/read/38525418/clinical-characteristics-and-prognostic-factors-of-male-breast-cancer-in-china
#15
JOURNAL ARTICLE
Han Lei, Baojie Hua, Yingying Mao, Wei Cui, Caiping Mao, Shaoxue Yang, Jiayu Li
PURPOSE: This study aimed to explore the clinical characteristics of male breast cancer (MBC) patients and the factors influencing their prognosis. METHODS: We conducted a retrospective case series analysis of 117 MBC cases who were treated at Zhejiang Cancer Hospital from 2009 to 2022. Cox proportional hazard model was used to identify prognostic factors of MBC. Nomogram was constructed based on these factors, which was further evaluated by C-index and calibration curves...
2024: Frontiers in Oncology
https://read.qxmd.com/read/38524554/association-of-padi2-and-padi4-polymorphisms-in-covid-19-host-severity-and-non-survival
#16
JOURNAL ARTICLE
Ilse Adriana Gutiérrez-Pérez, Ivette Buendía-Roldán, Oscar Zaragoza-García, Gloria Pérez-Rubio, José Rafael Villafan-Bernal, Leslie Chávez-Galán, Isela Parra-Rojas, Rafael de Jesús Hernández-Zenteno, Ingrid Fricke-Galindo, Natividad Castro-Alarcón, Brandon Bautista-Becerril, Ramcés Falfán-Valencia, Iris Paola Guzmán-Guzmán
BACKGROUND: Enzymes of the peptidylarginine deiminase family (PADs) play a relevant role in the pathogenesis of COVID-19. However, the association of single nucleotide polymorphisms (SNPs) in their genes with COVID-19 severity and death is unknown. METHODOLOGY: We included 1045 patients who were diagnosed with COVID-19 between October 2020 and December 2021. All subjects were genotyped for PADI2 (rs1005753 and rs2235926) and PADI4 (rs11203366, rs11203367, and rs874881) SNPs by TaqMan assays and their associations with disease severity, death, and inflammatory biomarkers were evaluated...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38524131/long-noncoding-rnas-and-circular-rnas-as-potential-diagnostic-biomarkers-of-inflammatory-bowel-diseases-a-systematic-review-and-meta-analysis
#17
Melaku Ashagrie Belete, Selamyhun Tadesse, Mihret Tilahun, Alemu Gedefie, Agumas Shibabaw, Zewudu Mulatie, Muluken Amare Wudu, Saba Gebremichael, Habtu Debash, Mihreteab Alebachew, Ermiyas Alemayehu
INTRODUCTION: Inflammatory bowel disease (IBD) poses a growing global burden, necessitating the discovery of reliable biomarkers for early diagnosis. The clinical significance of dysregulated expression of long noncoding RNAs (lncRNAs) and circular RNAs (circRNAs) in diagnosing IBD has not been well established. Thus, our study aimed to investigate the diagnostic value of lncRNAs and circRNAs for IBD based on currently available studies. METHODS: A comprehensive search was carried out in diverse electronic databases, such as PubMed, Embase, Scopus, Science Direct and Wiley Online Library to retrieve articles published until October 30, 2023...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38523686/prognostic-nutritional-index-predicts-efficacy-and-immune-related-adverse-events-of-first-line-chemoimmunotherapy-in-patients-with-extensive-stage-small-cell-lung-cancer
#18
JOURNAL ARTICLE
Baishen Zhang, Jing Chen, Hui Yu, Meichen Li, Muyan Cai, Likun Chen
BACKGROUND: Currently, there is a lack of well-established markers to predict the efficacy of chemoimmunotherapy in small-cell lung cancer (SCLC). Neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), advanced lung cancer inflammation index (ALI) and prognostic nutritional index (PNI) are associated with prognosis in several tumors, whereas their predictive role in SCLC remains unclear. METHODS: A retrospective study was conducted at Sun Yat-sen University Cancer Center, involving extensive-stage SCLC (ES-SCLC) patients who received first-line chemoimmunotherapy between January 2020 and December 2021...
2024: Journal of Inflammation Research
https://read.qxmd.com/read/38522433/the-impact-of-inflammatory-biomarkers-on-amputation-rates-in-patients-with-diabetic-foot-ulcers
#19
JOURNAL ARTICLE
Yun Xu, Ruina Geng, Xiangyu Meng, Zhipeng Feng, Xu Wang, Guanying Zhang, Liwei Bai
Diabetic Foot Ulcers (DFUs) are a major complication of diabetes, often leading to amputation. Understanding the relationship between haematological inflammatory markers and the incidence of amputation in DFU patients with infectious complications is crucial for improving management and outcomes. This retrospective study, conducted from May 2020 to October 2022, involved 109 patients with DFUs, categorised into amputation (AM) and non-amputation (NAM) groups. Patients were evaluated for various factors, including demographic data, DFU duration, and blood parameters such as haemoglobin A1c (HbA1c), haemoglobin (Hb), albumin (ALB), white blood cell count (WBC), erythrocyte sedimentation rate (ESR), procalcitonin (PCT), C-reactive protein (CRP), platelet-to-lymphocyte ratio (PLR), neutrophil-to-lymphocyte ratio (NLR), and lymphocyte-to-monocyte ratio (LMR)...
April 2024: International Wound Journal
https://read.qxmd.com/read/38522070/a-bacterial-toxin-co-opts-caspase-3-to-disable-active-gasdermin-d-and-limit-macrophage-pyroptosis
#20
JOURNAL ARTICLE
Skylar S Wright, Chengliang Wang, Atri Ta, Morena S Havira, Jianbin Ruan, Vijay A Rathinam, Sivapriya Kailasan Vanaja
During infections, host cells are exposed to pathogen-associated molecular patterns (PAMPs) and virulence factors that stimulate multiple signaling pathways that interact additively, synergistically, or antagonistically. The net effect of such higher-order interactions is a vital determinant of the outcome of host-pathogen interactions. Here, we demonstrate one such complex interplay between bacterial exotoxin- and PAMP-induced innate immune pathways. We show that two caspases activated during enterohemorrhagic Escherichia coli (EHEC) infection by lipopolysaccharide (LPS) and Shiga toxin (Stx) interact in a functionally antagonistic manner; cytosolic LPS-activated caspase-11 cleaves full-length gasdermin D (GSDMD), generating an active pore-forming N-terminal fragment (NT-GSDMD); subsequently, caspase-3 activated by EHEC Stx cleaves the caspase-11-generated NT-GSDMD to render it nonfunctional, thereby inhibiting pyroptosis and interleukin-1β maturation...
March 22, 2024: Cell Reports
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