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https://www.readbyqxmd.com/read/29147572/association-of-neutrophil-to-lymphocyte-ratio-with-inflammation-and-erythropoietin-resistance-in-chronic-dialysis-patients
#1
Jérôme Pineault, Caroline Lamarche, Robert Bell, Jean-Philippe Lafrance, Georges Ouellet, Martine Leblanc, Vincent Pichette, Sarah Bezzaoucha, Michel Vallée
Background: Neutrophil-to-lymphocyte ratio (NLR) was widely studied as a prognostic marker in various medical and surgical specialties, but its significance in nephrology is not yet established. Objective: We evaluated its accuracy as an inflammation biomarker in a dialysis population. Design setting: Single-center retrospective study. Patients: The records of all 550 patients who were treated with hemodialysis (HD) or peritoneal dialysis (PD) from September 2008 to March 2011 were included...
2017: Canadian Journal of Kidney Health and Disease
https://www.readbyqxmd.com/read/29147162/high-preoperative-neutrophil-lymphocyte-ratio-nlr-and-red-blood-cell-distribution-width-rdw-as-independent-predictors-of-native-arteriovenous-fistula-failure
#2
Rashid Usman, Muhammad Jamil, Muhammad Naveed
Objective: To study the association between a high preoperative neutrophil lymphocyte ratio (NLR) and red cell distribution width (RDW) with arteriovenous fistula (AVF) failure, as well as to determine the cut-off values in a South Asian population. Materials and Methods: A total of 150 consecutive patients with a failed fistula who presented in the Department of Vascular Surgery between January 2014 and January 2016. Patients fulfilling the inclusion criteria were selected as defined as Case. They were compared with 150 patients who had matured fistulae (Control)...
September 25, 2017: Annals of Vascular Diseases
https://www.readbyqxmd.com/read/29146805/the-structural-basis-of-flagellin-detection-by-naip5-a-strategy-to-limit-pathogen-immune-evasion
#3
Jeannette L Tenthorey, Nicole Haloupek, José Ramón López-Blanco, Patricia Grob, Elise Adamson, Ella Hartenian, Nicholas A Lind, Natasha M Bourgeois, Pablo Chacón, Eva Nogales, Russell E Vance
Robust innate immune detection of rapidly evolving pathogens is critical for host defense. Nucleotide-binding domain leucine-rich repeat (NLR) proteins function as cytosolic innate immune sensors in plants and animals. However, the structural basis for ligand-induced NLR activation has so far remained unknown. NAIP5 (NLR family, apoptosis inhibitory protein 5) binds the bacterial protein flagellin and assembles with NLRC4 to form a multiprotein complex called an inflammasome. Here we report the cryo-electron microscopy structure of the assembled ~1...
November 17, 2017: Science
https://www.readbyqxmd.com/read/29144205/lessons-in-effector-and-nlr-biology-of-plant-microbe-systems
#4
Aleksandra Białas, Erin K Zess, Juan Carlos De la Concepcion, Marina Franceschetti, Helen G Pennington, Kentaro Yoshida, Jessica L Upson, Emilie Chanclud, Chih-Hang Wu, Thorsten Langner, Abbas Maqbool, Freya A Varden, Lida Derevnina, Khaoula Belhaj, Koki Fujisaki, Hiromasa Saitoh, Ryohei Terauchi, Mark J Banfield, Sophien Kamoun
A diversity of plant-associated organisms secrete effectors-proteins and metabolites that modulate plant physiology to favor host infection and colonization. However, effectors can also activate plant immune receptors, notably nucleotide-binding domain and leucine-rich repeat region (NLR)-containing proteins, enabling plants to fight off invading organisms. This interplay between effectors, their host targets, and the matching immune receptors is shaped by intricate molecular mechanisms and exceptionally dynamic coevolution...
November 16, 2017: Molecular Plant-microbe Interactions: MPMI
https://www.readbyqxmd.com/read/29142761/aeromonas-hydrophila-utilizes-tlr4-topology-for-synchronous-activation-of-myd88-and-trif-to-orchestrate-anti-inflammatory-responses-in-zebrafish
#5
Nidhi Srivastava, Asha Shelly, Manmohan Kumar, Archana Pant, Bhabatosh Das, Tanmay Majumdar, Shibnath Mazumder
Toll-like receptor 4 (TLR4) plays a critical role in host immunity against Gram-negative bacteria. It transduces signals through two distinct TIR-domain-containing adaptors, MyD88 and TRIF, which function at the plasma membrane and endosomes, respectively. Using zebrafish Aeromonas hydrophila infection model, we demonstrate that synchronization of MyD88 and TRIF dependent pathways is critical for determining the fate of infection. Zebrafish were infected with A. hydrophila, and bacterial recovery studies suggested its effective persistence inside the host...
2017: Cell Death Discovery
https://www.readbyqxmd.com/read/29142418/marantodes-pumilum-blume-kuntze-inhibited-secretion-of-lipopolysaccharide-and-monosodium-urate-crystal-stimulated-cytokines-and-plasma-prostaglandin-e2
#6
Eldiza Puji Rahmi, Jamia Azdina Jamal, Endang Kumolosasi, Juriyati Jalil, Nor-Ashila Aladdin
Background: Marantodes pumilum is traditionally used for dysentery, gonorrhea, and sickness in the bones. Previous studies revealed its antibacterial and xanthine oxidase inhibitory activities. Objective: To evaluate the inhibitory effects of three M. pumilum varieties on the secretion of lipopolysaccharide (LPS)- and monosodium urate crystal (MSU)-induced cytokines and plasma prostaglandin E2 (PGE2) in vitro. Materials and Methods: The leaves and roots of M...
October 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29142183/worse-preoperative-status-based-on-inflammation-and-host-immunity-is-a-risk-factor-for-surgical-site-infections-in-colorectal-cancer-surgery
#7
Masano Sagawa, Kazuhiko Yoshimatsu, Hajime Yokomizo, Yuki Yano, Sachiyo Okayama, Takebumi Usui, Kentaro Yamaguchi, Shunichi Shiozawa, Takeshi Shimakawa, Takao Katsube, Hiroyuki Kato, Yoshihiko Naritaka
OBJECTIVE: The modified Glasgow Prognostic Score (mGPS) is an inflammation-based measure of malnutrition that reflects a state of cachexia in cancer patients. We evaluated mGPS as an index to predict surgical site infection (SSI) incidence in patients undergoing colorectal cancer surgery. SUBJECTS AND METHODS: We retrospectively analyzed 351 patients who underwent colon cancer resection. Factors correlated with the incidence of SSIs were identified by logistic analysis and stepwise selection...
2017: Journal of Nippon Medical School, Nippon Ika Daigaku Zasshi
https://www.readbyqxmd.com/read/29141813/the-neutrophil-to-lymphocyte-ratio-as-disease-actvity-marker-in-multiple-sclerosis-and-optic-neuritis
#8
A K Bisgaard, G Pihl-Jensen, J L Frederiksen
BACKGROUND: Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS). The neutrophil-to-lymphocyte ratio (NLR) has been identified as a disease activity marker in several diseases. We aim to evaluate the significance of the NLR in the different subtypes of MS, optic neuritis (ON) and in relation to disease activity and Expanded Disability Status Scale (EDSS). METHODS: We included 378 patients and 813 healthy controls (HC) from The Nordic Reference Interval Project 2000 (NORIP)...
November 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29138578/prognostic-value-of-the-c-reactive-protein-to-albumin-ratio-a-novel-inflammation-based-prognostic-indicator-in-osteosarcoma
#9
Yong-Jiang Li, Kai Yao, Min-Xun Lu, Wen-Biao Zhang, Cong Xiao, Chong-Qi Tu
The prognostic role of the C-reactive protein to albumin ratio (CRP/Alb ratio) in patients with osteosarcoma has not been investigated. A total of 216 osteosarcoma patients were enrolled in the study. Univariate and multivariate survival analyses between the groups were performed and Kaplan-Meier analysis was conducted to plot the survival curves. Receiver operating characteristic curves were generated and areas under the curve (AUCs) were compared to assess the discriminatory ability of the inflammation-based indicators, including CRP/Alb ratio, Glasgow prognostic score (GPS), neutrophil-lymphocyte ratio (NLR), and platelet-lymphocyte ratio (PLR)...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29138575/micrornas-as-a-novel-class-of-diagnostic-biomarkers-for-the-detection-of-osteosarcoma-a-meta-analysis
#10
Hong Liu, Ping Li, Liang Chen, Chao Jian, Zonghuan Li, Aixi Yu
MicroRNAs (miRNAs) have been considered as promising diagnostic biomarkers for many diseases, especially for cancers. Numerous studies have reported the value of miRNAs in the diagnosis of osteosarcoma (OS), but the results vary greatly across different studies. Therefore, we conducted this meta-analysis to assess the prospective diagnostic value of miRNAs in diagnosing OS. All relevant articles from prior to July 28, 2017 were selected from PubMed, EMBASE, Web of Science, Cochrane Library, Chinese National Knowledge Infrastructure, and Wan-fang databases...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29138376/-the-changes-in-the-neutrophil-to-lymphocyte-ratio-can-predict-the-timing-of-chemotherapeutic-regimen-alteration-in-patients-with-metastatic-colorectal-cancer
#11
Katsuki Muneoka, Yoshio Shirai, Masataka Sasaki, Shinsuke Honma, Jun Sakata, Junkichi Kanda, Hiroyuki Wakabayashi, Toshifumi Wakai
AIM: In order to determine if the changes in the neutrophil-to-lymphocyte ratio(NLR)can predict the timingof regimen alteration, the outcome of chemotherapy for metastatic colorectal cancer was analyzed retrospectively. METHODOLOGY: Thirty patients with unresectable metastatic colorectal cancer were administered chemotherapy from January 2005 to December 2015 at the Niitsu Medical Center Hospital. The NLR was calculated from complete blood counts obtained prior to administration of chemotherapy and at the time of the best response...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29137187/clinical-usefulness-of-the-platelet-to-lymphocyte-ratio-in-patients-with-angiosarcoma-of-the-face-and-scalp
#12
Gen Suzuki, Hideya Yamazaki, Norihiro Aibe, Koji Masui, Naomi Sasaki, Daisuke Shimizu, Takuya Kimoto, Jun Asai, Makoto Wada, Satoshi Komori, Norito Katoh, Kei Yamada
Angiosarcoma of the face and scalp (ASFS) is an extremely aggressive tumor that frequently metastasizes, often leading to death. The neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and lymphocyte-to-monocyte ratio (LMR) are inflammatory markers that predict outcome of various cancers. We aimed to examine the relationship between pretreatment inflammatory markers and ASFS outcome. We included 17 patients with ASFS and a control group of 56 age- and gender-matched healthy individuals...
November 13, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29137097/prognostic-role-of-neutrophil-lymphocyte-ratio-in-patients-with-acute-ischemic-stroke
#13
Jing Zhang, Qingqing Ren, Yanlin Song, Min He, Yunhui Zeng, Zhiyong Liu, Jianguo Xu
BACKGROUND: The aim of this study was to evaluate the prognostic role of neutrophil-lymphocyte ratio (NLR) in patients with acute ischemic stroke (AIS). METHODS: PubMed, Embase, Web of Science, Cochrane Library, and China National Knowledge Infrastructure were searched for potential eligible literature. The study characteristics and relevant data were extracted. Odds ratios (ORs) with 95% confidence intervals (CIs) were pooled to estimate the prognostic role of NLR in patients with AIS...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29137051/neutrophil-to-lymphocyte-and-aspartate-to-alanine-aminotransferase-ratios-predict-hepatocellular-carcinoma-prognosis-after-transarterial-embolization
#14
Chang Liu, Bang-Sheng Jia, Bing-Wen Zou, Hua Du, Lu-Nan Yan, Jia-Yin Yang, Li Jiang, Tian-Fu Wen, Wu-Sheng Lu
The neutrophil-to-lymphocyte ratio (NLR) reflects the systematic inflammatory status, and the aspartate aminotransferase-to-alanine aminotransferase ratio (AAR) is a biomarker of liver fibrosis and cirrhosis. These values can be conveniently obtained from routine blood tests; however, their combined clinical utility has not been extensively studied in patients with hepatocellular carcinoma (HCC) undergoing transarterial chemoembolization (TACE). This study aimed to investigate the prognostic value of NLR-AAR in patients with unresectable HCC undergoing TACE...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29137012/the-relationship-between-neutrophil-to-lymphocyte-ratio-and-diabetic-peripheral-neuropathy-in-type-2-diabetes-mellitus
#15
Tingting Xu, Zihua Weng, Chu Pei, Siyuan Yu, Yating Chen, Wenjie Guo, Xingzuo Wang, Peng Luo, Jia Sun
To explore the relationship between neutrophil-to-lymphocyte ratio (NLR) and diabetic peripheral neuropathy (DPN) in type 2 diabetes mellitus.A total of 557 newly diagnosed Type 2 Diabetes Mellitus (T2DM) patients were recruited, including 397 T2DM patients without complication (DM group) as well as 160 T2DM patients complicated with DPN (DPN group). Student t test, Mann-Whitney U test, or χ test was applied to the data of the 2 groups, including the levels of neutrophils and lymphocytes as well as the NLR values of peripheral blood and other biochemistry indexes; Pearson correlation analysis was used to calculate the correlation of NLR and detected factors; risk factors of DPN were estimated via logistic regression analysis and multivariate analysis...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29137007/prognostic-role-of-pretreatment-neutrophil-to-lymphocyte-ratio-in-breast-cancer-patients-a-meta-analysis
#16
Xu Liu, Jing-Kun Qu, Jia Zhang, Yan Yan, Xi-Xi Zhao, Ji-Zhao Wang, Hang-Ying Qu, Lin Liu, Jian-Sheng Wang, Xiao-Yi Duan
BACKGROUND: Inflammation and cancer are closely related to each other. As a parameter that can reflect inflammation and host immune reaction, elevated blood neutrophil to lymphocyte ratio (NLR) has been confirmed to be correlated with poor prognosis in a variety of cancers. However, this remains controversial in breast cancer. Thus, we performed this updated meta-analysis to further clarify whether high NLR could be a predictor of survival in breast cancer patients. METHODS: We searched on PubMed Database and Cochrane Library...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29134377/markers-of-systemic-inflammatory-response-are-prognostic-factors-in-patients-with-pancreatic-neuroendocrine-tumors-pnets-a-prospective-analysis
#17
Apostolos Gaitanidis, Dhaval Patel, Naris Nilubol, Amit Tirosh, Samira Sadowski, Electron Kebebew
BACKGROUND: The prognosis and behavior of pancreatic neuroendocrine tumors (PNETs) vary and may be divergent even at the same stage or tumor grade. Markers of systemic inflammatory response are readily available and are inexpensive, and have been shown to be prognostic factors in several cancers. OBJECTIVE: The aim of this study was to evaluate the prognostic utility of markers of systemic inflammatory response in patients with PNETs. METHODS: A prospective study of 97 patients with PNETs was performed (median follow-up of 15 months, range 12-73 months)...
November 13, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29134253/the-role-of-the-neutrophil-lymphocyte-ratio-nlr-and-the-crp-albumin-ratio-car-in-predicting-mortality-following-emergency-laparotomy-in-the-over-80-age-group
#18
G Simpson, R Saunders, J Wilson, C Magee
INTRODUCTION: Emergency laparotomy in the elderly is an increasingly common procedure which carries high morbidity and mortality. Risk prediction tools, although imperfect, can help guide management decisions. Novel markers of surgical outcomes may contribute to these scoring systems. The neutrophil:lymphocyte ratio (NLR) and CRP:albumin ratio (CAR) have been associated with outcomes in malignancy and sepsis. We assessed the use of ratio NLR and CAR as prognostic indicators in patients over the age of 80 undergoing emergency laparotomy...
November 13, 2017: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
https://www.readbyqxmd.com/read/29132766/neutrophil-to-lymphocyte-ratio-predict-mortality-and-major-adverse-cardiac-events-in-acute-coronary-syndrome-a-systematic-review-and-meta-analysis
#19
Chao-Hui Dong, Zhang-Min Wang, Si-Yu Chen
OBJECTIVES: Neutrophil to lymphocyte ratio (NLR) might be associated with the mortality or major adverse cardiac events (MACEs) in acute coronary syndrome (ACS) patients. We performed a meta-analysis to evaluate the correlation between NLR and mortality/MACEs in ACS. METHODS: We assessed clinical trials through Pubmed, EMBASE, the Cochrane Library and Web of science in investigating the association between NLR and mortality/MACEs in ACS patients up to August 15, 2017...
November 10, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/29132702/neutrophil-lymphocyte-ratio-prognostic-impact-in-heart-surgery-early-outcomes-and-late-survival
#20
Shuli Silberman, Ulfat Abu-Yunis, Rachel Tauber, Linda Shavit, Tal Grenader, Daniel Fink, Daniel Bitran, Ofer Merin
BACKGROUND: The neutrophil-lymphocyte ratio (NLR) is a recognized marker of inflammation associated with poor outcomes in various clinical situations. We analyzed the prognostic significance of preoperative elevated NLR in patients undergoing cardiac surgery. METHODS: We performed a retrospective review of 3,027 consecutive patients undergoing cardiac surgery. Receiver-operating-characteristic was used to determine the cutoff value for elevated NLR. Multivariate regression was used to determine the predictive value of preoperative NLR on clinical outcomes...
November 10, 2017: Annals of Thoracic Surgery
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