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Giovanna Mantovani, Anna Spada
Heterozygous inactivating mutations in the Gs alpha gene cause Albright's hereditary osteo-dystrophy (AHO). Consistent with the observation that only maternally inherited mutations lead to resistance to hormone action (pseudohypoparathyroidism type Ia [PHP-Ia), recent studies have provided evidence for a predominant maternal origin of Gs alpha transcripts in endocrine organs, such as thyroid, gonad and pituitary. Accordingly, patients with PHP-Ia display variable degrees of resistance to parathyroid hormone (PTH), thyroid stimulating hormone (TSH), gonadotropins and growth hormone (GH) releasing hormone (GHRH)...
May 2006: Journal of Pediatric Endocrinology & Metabolism: JPEM
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JOURNAL ARTICLE
M Brito Suárez, C Hernández, J de la Rosa
No abstract text is available yet for this article.
1975: Revista Española de Reumatismo y Enfermedades Osteoarticulares
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