Lei He, Zhaozhao Li, Danjie Su, Haichen Du, Kuo Zhang, Wangqian Zhang, Shuning Wang, Fei Xie, Yueyuan Qiu, Shuangxin Ma, Gege Shi, Duo Yu, Xiaoying Lei, Weina Li, Meng Li, Zhaowei Wang, Jintao Gu, Yingqi Zhang
Cancer immunotherapy has demonstrated significant efficacy in various tumors, but its effectiveness in treating Hepatocellular Carcinoma (HCC) remains limited. Therefore, there is an urgent need to identify a new immunotherapy target and develop corresponding intervention strategies. Bioinformatics analysis has revealed that growth differentiation factor 15 (GDF15) is highly expressed in HCC and is closely related to poor prognosis of HCC patients. The previous study revealed that GDF15 can promote immunosuppression in the tumor microenvironment...
May 5, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)