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https://www.readbyqxmd.com/read/29239743/phenotypic-and-molecular-spectrum-of-aicardi-gouti%C3%A3-res-syndrome-a-study-of-24-patients
#1
Fuad Al Mutairi, Majid Alfadhel, Marwan Nashabat, Ayman W El-Hattab, Tawfeg Ben-Omran, Jozef Hertecant, Wafaa Eyaid, Rehab Ali, Ali Alasmari, Majdi Kara, Waleed Al-Twaijri, Rana Filimban, Abduljabbar Alshenqiti, Mohammed Al-Owain, Eissa Faqeih, Fowzan S Alkuraya
BACKGROUND: Aicardi-Goutières syndrome is a rare genetic neurological disorder with variable clinical manifestations. Molecular detection of specific mutations is required to confirm the diagnosis. The aim of this retrospective study was to review the clinical and molecular diagnostic findings in 24 cases of Aicardi-Goutières syndrome presenting in childhood in the Arab population. MATERIALS AND METHODS: We reviewed the records of 24 patients from six tertiary hospitals in different Arab countries...
October 5, 2017: Pediatric Neurology
https://www.readbyqxmd.com/read/29238490/gastroesophageal-reflux-disease-among-population-of-arar-city-northern-saudi-arabia
#2
Anwar Matar Alsulobi, Nagah Mohamed Abo El-Fetoh, Sara Ghazi Eid Alenezi, Razan Ahmed Alanazi, Rawan Hamdan Salem Alenazy, Fryail Aied Lafi Alenzy, Amthal Alturqi Alenzi, Aisha Melfy Al Hazmy, Kholoud Obeid Albathaly, Rehab Jazem Fattal Alruwaili, Ibtisam Matan Alanazi, Ebtihal Ahmad Ali Alghamdi, Maryam Saeed Alanazi, Najah Owaed Aienzi
Background: During the recent decade, several studies about prevalence of symptom-based GERD have revealed increase of its prevalence. In addition to the highly disturbing typical symptoms, it has a series of known consequences and may affect the quality of life. Objective: To determine the prevalence of gastroesophageal reflux disease (GERD) as well as their main characteristics and risk factors among the population of Arar City, Northern Saudi Arabia. Methods: A cross-sectional study was carried out on a sample of 302 individuals from population of Arar city from October 01, 2016 to May 30, 2017, using a researcher made questionnaire and checklist...
October 2017: Electronic Physician
https://www.readbyqxmd.com/read/29228824/development-of-novel-bioadhesive-granisetron-hydrochloride-spanlastic-gel-and-insert-for-brain-targeting-and-study-their-effects-on-rats
#3
Rehab Abdelmonem, Mohamed El Nabarawi, Alshaimaa Attia
The aim of this study was to formulate granisetron hydrochloride (GH) spanlastic in mucoadhesive gels and lyophilized inserts for intranasal administration to improve GH bioavailability and brain targeting. Carpapol 934 and HPMC were incorporated in GH spanlastic in nasal gels (GHSpNGs). Gelatin and HPMC as matrix former, glycine as a collapse protecting and mannitol as an insert filler and sweeting agent were used to prepare GH spanlastic loaded in lyophilized inserts (GHSpNIs). The prepared GHSpNGs were characterized for pH measurement, drug content, rheology, and in vitro drug release...
November 2018: Drug Delivery
https://www.readbyqxmd.com/read/29218260/a-case-of-streptococcus-anginosus-brain-abscess-caused-by-contiguous-spread-from-sinusitis-in-an-immunocompetent-patient
#4
Nathan Esplin, John W Stelzer, Sean All, Sundeep Kumar, Ejaz Ghaffar, Sayed Ali
Brain abscesses are infections of the brain parenchyma that can arise from either contiguous spread from local infection or by hematogenous spread from a distant site. Streptococcus anginosus of the Streptococcus anginosus group (SAG) is a commensal microbe of the mucosae of the oral cavity, gastrointestinal tract, and urogenital tract. We present a case of mono-microbial brain abscess caused by contiguous spread from relatively asymptomatic sinusitis that initially presented as a subdural hemorrhage on computed tomography...
October 4, 2017: Curēus
https://www.readbyqxmd.com/read/29201276/antihypertensive-effects-of-roselle-olive-combination-in-l-name-induced-hypertensive-rats
#5
Rehab F Abdel-Rahman, Alyaa F Hessin, Marwan Abdelbaset, Hanan A Ogaly, Reham M Abd-Elsalam, Salah M Hassan
This study aimed to evaluate the antihypertensive efficacy of a new combination therapy of Hibiscus sabdariffa and Olea europaea extracts (2 : 1; Roselle-Olive), using N(G)-nitro-L-arginine-methyl ester- (L-NAME-) induced hypertensive model. Rats received L-NAME (50 mg/kg/day, orally) for 4 weeks. Concurrent treatment with Roselle-Olive (500, 250, and 125 mg/kg/day for 4 weeks) resulted in a dose-dependent decrease in both systolic and diastolic blood pressure, reversed the L-NAME-induced suppression in serum nitric oxide (NO), and improved liver and kidney markers, lipid profile, and oxidative status...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29199218/uses-of-cyclohexan-1-4-dione-for-the-synthesis-of-2-amino-4-5-dihydrobenzo-b-thiophen-6-7h-one-derivatives-with-anti-proliferative-and-pim-1-kinase-activities
#6
Rafat Milad Mohareb, Nermeen Saeed Abbas, Rehab Ali Ibrahim
The reaction of cyclohexan-1,4-dione with elemental sulfur and any of the 2-cyano-N-arylacetamide derivatives 2a-c gave the 2-amino-4,5-dihydrobenzo[b]thiophen-6(7H)-one derivatives 3a-c to be used in some heterocyclization reactions. The multicomponent reactions of any of compounds 3a-c with aromatic aldehydes 6a-c and either of malononitrile or ethylcyanoacetate gave the 5,9-dihydro-4H-thieno[2,3-f]chromene derivatives 9a-r, respectively. The anti-proliferative evaluation of the newly synthesized compounds against the six cancer cell lines A549, HT-29, MKN-45, U87MG, SMMC-7721 and H460 showed that the nine compounds 3c, 5c, 9e, 9h, 9i, 9j, 9l, 9q, 11e and 13e with highest cytotoxcity...
2017: Chemical & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29197371/partnering-around-cancer-clinical-trials-pacct-study-protocol-for-a-randomized-trial-of-a-patient-and-physician-communication-intervention-to-increase-minority-accrual-to-prostate-cancer-clinical-trials
#7
Susan Eggly, Lauren M Hamel, Elisabeth Heath, Mark A Manning, Terrance L Albrecht, Ellen Barton, Mark Wojda, Tanina Foster, Michael Carducci, Dina Lansey, Ting Wang, Rehab Abdallah, Narineh Abrahamian, Seongho Kim, Nicole Senft, Louis A Penner
BACKGROUND: Cancer clinical trials are essential for testing new treatments and represent state-of-the-art cancer treatment, but only a small percentage of patients ever enroll in a trial. Under-enrollment is an even greater problem among minorities, particularly African Americans, representing a racial/ethnic disparity in cancer care. One understudied cause is patient-physician communication, which is often of poor quality during clinical interactions between African-American patients and non-African-American physicians...
December 2, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29194268/rapid-anterior-segmental-maxillary-retraction-by-compression-osteogenesis
#8
Usama Saad Hellal, Nabila Fayed, Rehab Elsharkawy, Mostafa Abdelrahmen
Maxillary protrusion is one of the deformities of the upper jaw. Orthodontics and orthodontics combined with anterior segmental osteotomy are the common treatment strategies for this deformity. The hypothesis of this study was that the maxillary bone segment could be gradually moved backward safely by using a tooth-borne-specific compression device that causes bone compression at the bony segment interface after performance of surgical bone cuts in cases of anterior maxillary protrusion. Ten patients with skeletal maxillary protrusion were treated by modified subapical maxillary osteotomy...
November 20, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29193367/cytotoxic-activity-of-carotenoid-rich-fractions-from-haematococcus-pluvialis-and-dunaliella-salina-microalgae-and-the-identification-of-the-phytoconstituents-using-lc-dad-esi-ms
#9
Farouk K El-Baz, Rehab A Hussein, Khaled Mahmoud, Sayeda M Abdo
Microalgae represent a rich source that satisfies the growing need for novel ingredients of nutriceuticals, pharmaceuticals, and food supplements. Haematococcus pluvialis and Dunaliella salina microalgae are isolated from the Egyptian hydro-flora and are reported for their potent antioxidant activities. The cytotoxic activity of different fractions of both microalgae was investigated on 4 cell lines HePG2, MCF7, HCT116, and A549. The carotenoid rich fraction of H. pluvialis showed potent cytotoxic activity against colon cancer cell line and moderate activity against both liver and breast cancer cell lines...
November 29, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29188336/no-risk-of-arthrofibrosis-after-acute-anterior-cruciate-ligament-reconstruction
#10
Karl Eriksson, Christoffer von Essen, Sven Jönhagen, Björn Barenius
PURPOSE: To compare acute ACL reconstruction (ACLR) within 8 days of injury with delayed reconstruction after normalized range of motion (ROM), 6-10 weeks after injury. It was hypothesized that acute ACL reconstruction with modern techniques is safe and can be beneficial in terms of patient-reported outcomes and range of motion. METHODS: Sample size calculation indicated 64 patients would be required to find a 5° difference in ROM at 3 months. Seventy patients with high recreational activity level, Tegner level 6 or more, were randomized to acute (within 8 days) or delayed (6-10 weeks) ACLR between 2006 and 2013...
November 29, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/29182473/data-mining-analysis-of-the-provision-of-mobility-devices-in-the-united-states-with-emphasis-on-complex-rehab-technology
#11
Stephen Sprigle, Susan Johnson Taylor
The objective of this study was to describe the provision of wheeled-mobility equipment from the perspective of a large equipment supplier in the United States. The records of clients who were prescribed a mobility device over a 6-month period were randomly sampled to product a dataset of 1689 clients. Analysis was limited to descriptive statistics and measures of relationships. The majority of the clients were adults (72%) and female (58%) with 62% receiving a manual wheelchair. The majority of interventions (58%) included some contribution from the client or client's family...
November 28, 2017: Assistive Technology: the Official Journal of RESNA
https://www.readbyqxmd.com/read/29173998/-rehabilitation-in-elderly-frail-patients-with-acute-heart-failure-training-in-rehab-hf-pilot-study
#12
Paola Beltrán Troncoso, Francesc Formiga
No abstract text is available yet for this article.
November 21, 2017: Revista Española de Geriatría y Gerontología
https://www.readbyqxmd.com/read/29157230/barriers-and-facilitators-to-implementing-an-evidence-based-woman-focused-intervention-in-south-african-health-services
#13
Brittni N Howard, Richard Van Dorn, Bronwyn J Myers, William A Zule, Felicia A Browne, Tara Carney, Wendee M Wechsberg
BACKGROUND: Since the beginning of the HIV epidemic, numerous behavior change, risk-reduction, and biomedical interventions have been developed and tested. While some of these interventions have shown to be efficacious in randomized trials, it often takes almost two decades for an intervention to be translated into practice. Meanwhile, South Africa continues to have among the highest prevalence of HIV globally, with women of childbearing age bearing the burden of the epidemic. Given the urgency of the HIV epidemic among vulnerable women in South Africa, it is imperative that evidence-based interventions be implemented rapidly into practice...
November 21, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/29152794/highly-sustainable-zinc-anodes-for-the-rechargeable-hybrid-aqueous-battery
#14
Kyung Eun Kate Sun, Tuan Hoang, The Nam Long Doan, Yan Yu, Pu Chen
The synthesis of novel zinc electrodes has been successfully implemented by the electroplating method with the aid of inorganic additives in the electroplating solution. The selected inorganic additives are indium sulfate, tin oxide, and boric acid. From X-ray diffraction results, the synthesized zinc electrodes prefer (002) and/or (103) crystallographic orientations, representing basal morphology and high resistance to dendrite growth. The corrosion rates of these electroplated zinc samples decrease as much as 11 times smaller than the rate of a zinc foil when the zinc materials are in contact with the aqueous electrolyte of a rechargeable hybrid aqueous battery (ReHAB)...
November 19, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29144789/a-comparative-study-of-different-amniotic-membrane-orientations-during-extraocular-muscle-surgery-in-rabbits
#15
Rehab Rashad Kassem, Randa Mohamed Abdel-Moneim El-Mofty, Mustafa Mahmoud Khodeir, Wael Mostafa Hamza
PURPOSE: To histopathologically compare the effect of different orientations of cryopreserved human amniotic membrane (AM) transplant during extraocular muscle surgery in rabbits. METHODS: Fifty-two albino rabbit eyes underwent 4-mm resection of the superior rectus. Eyes were randomly divided into four groups. In Group C (Control group, 16 eyes) the muscle was not wrapped with amniotic membrane. In the three AM groups, cryopreserved AM was wrapped around the muscle, oriented with either its stroma (Group S, 15 eyes) or epithelium (Group E, nine eyes) towards the muscle, or folded on itself with the epithelium externally (Group F, 12 eyes)...
November 16, 2017: Current Eye Research
https://www.readbyqxmd.com/read/29127787/e-cigarette-marketing-exposure-and-combustible-tobacco-use-among-adolescents-in-the-united-states
#16
Rehab Auf, Mary Jo Trepka, Moaz Selim, Ziyad Ben Taleb, Mario De La Rosa, Miguel Ángel Cano
E-cigarette advertising has been shown to be associated with use of e-cigarettes, but its association with tobacco use has not been studied. Therefore, we examined the association between e-cigarettes advertisement and tobacco use. Data from nationally representative 22,007 middle and high school students (grades 6-12) were used to conduct the analysis. Logistic regression models estimated the adjusted odds ratios (AOR) of ever and current use of cigarette, hookah, cigar, and polytobacco use. Odds ratios were weighted and adjusted for study design, non-response rates, school level, gender, race/ethnicity, e-cigarette use, and smoking at home...
October 14, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/29123562/the-role-of-occupational-and-physiotherapy-in-multi-modal-approach-to-tackling-delirium-in-the-intensive-care
#17
REVIEW
Jenny Rains, Nigel Chee
The presence of delirium within critical care remains a long-standing challenge for patients and clinicians alike. A myriad of pre-disposing and precipitating factors lead to this patient cohort being high risk for developing delirium during their critical care stay. Until now, non-pharmacological management of these patients usually encompasses a 'bundle' of principles to reduce delirium days. These bundles have limited focus on the entire multi-disciplinary team (including occupational therapists and physiotherapists) who could assist with the reduction of delirium...
November 2017: Journal of the Intensive Care Society
https://www.readbyqxmd.com/read/29122531/uplc-pda-esi-qtof-ms-profiling-and-potent-anti-hsv-ii-activity-of-eucalyptus-sideroxylon-leaves
#18
Mona M Okba, Rania A El Gedaily, Rehab M Ashour
Eucalyptus is one of the most important and highly exploited genus in family Myrtaceae. An UPLC/PDA/ESI-qTOF-MS method was adopted to identify Eucalyptus sideroxylon Cunn. ex Woolls leaves phytoconstituents. Cytotoxicity of E. sideroxylon leaves phloroglucinol-rich extract (PGRE) on VERO cells was determined. The antiviral effect of PGRE against hepatitis A (HAV), herpes simplex type 1 (HSV-I), herpes simplex type 2 (HSV-II), coxsackie (CoxB4), and adenoviruses was in vitro evaluated using MTT assay (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium bromide)...
November 2, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29120582/role-of-ptpn22-1858-c-t-polymorphisms-in-juvenile-idiopathic-arthritis-in-egyptian-patients
#19
Yasser A Soliman, Nashwa I Hashaad, Sherin M Emam, Rehab R Mohamed
Juvenile idiopathic arthritis (JIA) the most common chronic arthropathy of childhood is a diverse group of chronic arthritis diseases. The protein tyrosine phosphatase N22 (PTPN22) gene exhibits regulatory activities for both T and B cells. This study aimed to study PTPN gene polymorphism in JIA. The study included 60 children with JIA and 40 age and sex matched healthy children as controls. Patients and control groups were subjected to PTPN gene polymorphism analysis. Our findings indicated a significant difference in PTPN22 polymorphism between JIA patients and the control group (P = 0...
January 2017: Egyptian Journal of Immunology
https://www.readbyqxmd.com/read/29112939/serious-games-for-arm-rehabilitation-of-persons-with-multiple-sclerosis-a-randomized-controlled-pilot-study
#20
Johanna Jonsdottir, Rita Bertoni, Michael Lawo, Angelo Montesano, Thomas Bowman, Silvia Gabrielli
OBJECTIVES: The feasibility and preliminary evidence for efficacy of a serious games platform compared to exergame using the Wii for arm rehabilitation in persons with multiple sclerosis (MS) was investigated. METHODS: A pilot single-blind randomized (2:1) controlled in clinic trial was carried out. Sixteen persons with MS participated (age years 56.8 (SD 12.3), MS-onset years 19.4 (SD 12.3), EDSS 6.5). Ten participants used a serious games platform (Rehab@Home) while 6 participants played with the commercial Wii platform, for four weeks (40min, 12 sessions/4 weeks)...
October 28, 2017: Multiple Sclerosis and related Disorders
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