keyword
MENU ▼
Read by QxMD icon Read
search

Bone and mineral

keyword
https://www.readbyqxmd.com/read/28334709/micronutrients-essential-fatty-acids-and-bone-health-in-phenylketonuria
#1
Serwet Demirdas, Francjan J van Spronsen, Carla E M Hollak, J Hanneke van der Lee, Peter H Bisschop, Fred M Vaz, Nienke M Ter Horst, M Estela Rubio-Gozalbo, Annet M Bosch
INTRODUCTION: In phenylketonuria (PKU), a natural protein-restricted dietary treatment prevents severe cognitive impairment. Nutrient deficiencies may occur due to strict diet. This study is aimed at evaluating the dietary intake and blood concentrations of micronutrients and essential fatty acids (FA), bone mineral density (BMD) and fracture history in patients on long-term dietary treatment. METHODS: Sixty early diagnosed Dutch patients (aged 1-39 years) were included in a multi-center cross-sectional study...
March 24, 2017: Annals of Nutrition & Metabolism
https://www.readbyqxmd.com/read/28334520/new-approach-for-vertical-bone-regeneration-using-in-situ-gelling-and-sustained-bmp-2-releasing-poly-phosphazene-hydrogel-system-on-peri-implant-site-with-critical-defect-in-a-canine-model
#2
Bo-Bae Seo, Hae-Im Chang, Hyuck Choi, Jeong-Tae Koh, Kwi-Dug Yun, Jae-Yeol Lee, Soo-Chang Song
An injectable hydrogel system with sustained bone morphogenetic protein 2 (BMP-2) release ability was developed for vertical bone regeneration at peri-implant sites and enhanced osseointegration of dental implants. In three young male beagle dogs, a pair of defects was created on both sides of the mandibular bone. Next, two implants were transplanted into each defect. In situ gelling polymer solutions with or without BMP-2 were applied to cover the implants and mandibular defects. The effects of the in situ gelling and sustained BMP-2 releasing (IGSR) hydrogel system on peri-implant bone regeneration were evaluated by radiologic examination, micro-computed tomography, and histomorphometric analysis...
March 23, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28334367/modeling-of-stiffness-and-strength-of-bone-at-nanoscale
#3
Diab W Abueidda, Fereshteh A Sabet, Iwona M Jasiuk
Two distinct geometrical models of bone at nanoscale (collagen fibril and mineral platelets) are analyzed computationally. In the first model (Model I) minerals are periodically distributed in a staggered manner in a collagen matrix while in the second model (Model II) minerals form continuous layers outside the collagen fibril. Elastic modulus and strength of bone at the nanoscale, represented by these two models, are studied using a finite element software Abaqus. The analysis employs a traction-separation law (cohesive surface modeling) at various interfaces in the models to account for interfacial delaminations...
March 23, 2017: Journal of Biomechanical Engineering
https://www.readbyqxmd.com/read/28334220/effect-of-vitamin-d-deficiency-in-developed-countries
#4
Zaki K Hassan-Smith, Martin Hewison, Neil J Gittoes
Introduction: Vitamin D deficiency is common worldwide with adverse effects on skeletal health. In recent years, there has been great interest in non-classical actions of vitamin D. Basic research has uncovered actions in a range of non-skeletal tissues, and observational studies have identified inverse relationships with risk of a number of disease states including sarcopenia, obesity, the metabolic syndrome, cardiovascular disease, cancer and autoimmune diseases. Sources of data: PubMed, Medline and Cochrane Systematic Reviews...
March 9, 2017: British Medical Bulletin
https://www.readbyqxmd.com/read/28334006/assessing-various-infrared-ir-microscopic-imaging-techniques-for-post-mortem-interval-evaluation-of-human-skeletal-remains
#5
Claudia Woess, Seraphin Hubert Unterberger, Clemens Roider, Monika Ritsch-Marte, Nadin Pemberger, Jan Cemper-Kiesslich, Petra Hatzer-Grubwieser, Walther Parson, Johannes Dominikus Pallua
Due to the influence of many environmental processes, a precise determination of the post-mortem interval (PMI) of skeletal remains is known to be very complicated. Although methods for the investigation of the PMI exist, there still remains much room for improvement. In this study the applicability of infrared (IR) microscopic imaging techniques such as reflection-, ATR- and Raman- microscopic imaging for the estimation of the PMI of human skeletal remains was tested. PMI specific features were identified and visualized by overlaying IR imaging data with morphological tissue structures obtained using light microscopy to differentiate between forensic and archaeological bone samples...
2017: PloS One
https://www.readbyqxmd.com/read/28333972/evaluation-of-high-resolution-in-vivo-mri-for-longitudinal-analysis-of-endochondral-fracture-healing-in-mice
#6
Melanie Haffner-Luntzer, Fabian Müller-Graf, Romano Matthys, Yvonne Hägele, Verena Fischer, René Jonas, Alireza Abaei, Florian Gebhard, Volker Rasche, Anita Ignatius
Mice are extensively used for experimental bone-healing studies. However, there are few established nondestructive in vivo techniques for longitudinal fracture-healing analysis in mice, including in vivo micro-computed tomography (μCT) and radiography. Importantly, none of the established methods can discriminate between non-mineralized fibrous tissue and cartilage in the soft fracture callus. Therefore, the objective was to establish high-resolution in vivo magnetic resonance imaging (MRI) for the longitudinal assessment of soft callus formation during bone healing in mice...
2017: PloS One
https://www.readbyqxmd.com/read/28332697/alpha-1-antitrypsin-inhibits-rankl-induced-osteoclast-formation-and-functions
#7
Mohammad Ahsanul Akbar, David Nardo, Mong-Jen Chen, Ahmed S Elshikha, Rubina Ahamed, Eslam M Elsayed, Claire Bigot, Lexie Shannon Holliday, Sihong Song
Osteoporosis is a global public health problem affecting more than 200 million people worldwide. We previously showed that treatment with alpha-1 antitrypsin (AAT), a multifunctional protein with anti-inflammatory properties, mitigated bone loss in an ovariectomized mouse model. However, the underlying mechanisms of the protective effect of AAT on bone tissue are largely unknown. In this study, we investigated the effect of AAT on osteoclast formation and function in vitro. Our results showed that AAT dose-dependently inhibited the formation of RANKL (receptor activator of nuclear factor κB ligand) induced osteoclasts derived from mouse bone marrow macrophages/monocyte (BMM) lineage cells and the murine macrophage cell line, RAW 264...
March 21, 2017: Molecular Medicine
https://www.readbyqxmd.com/read/28332281/collagen-type-xv-and-the-osteogenic-status
#8
Gina Lisignoli, Elisabetta Lambertini, Cristina Manferdini, Elena Gabusi, Letizia Penolazzi, Francesca Paolella, Marco Angelozzi, Veronica Casagranda, Roberta Piva
We have previously demonstrated that collagen type XV (ColXV) is a novel bone extracellular matrix (ECM) protein. It is well known that the complex mixture of multiple components present in ECM can help both to maintain stemness or to promote differentiation of stromal cells following change in qualitative characteristics or concentrations. We investigated the possible correlation between ColXV expression and mineral matrix deposition by human mesenchymal stromal cells (hMSCs) with different osteogenic potential and by osteoblasts (hOBs) that are able to grow in culture medium with or without calcium...
March 22, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28332217/imaging-for-vascular-calcification
#9
Paolo Raggi, W Charles O'Neill
Chronic decline in renal function is accompanied by deterioration of bone structure and function and progressive calcification of the vascular system. Both disease states have been linked with increased morbidity and mortality in chronic kidney disease. The severe alterations of mineral metabolism inherent with loss of renal function have an impact on vascular calcification development and progression, and several investigators have focused on ways to reduce their impact on vascular health. Imaging has contributed an important role in the assessment of vascular calcification, and the impact of various interventions aimed at curbing their progression...
March 22, 2017: Seminars in Dialysis
https://www.readbyqxmd.com/read/28332213/hen-egg-york-phosvitin-stimulates-osteoblast-differentiation-in-the-absence-of-ascorbic-acid
#10
Qingli Liu, Chunyan Li, Fang Geng, Xi Huang, Meihu Ma
BACKGROUND: Egg yolk phosvitin, one of the most highly phosphorylated extracellular matrix proteins known in nature, has a strong calcium binding and reducing capacity. Here, we investigated the effects of phosvitin on the osteoblast differentiation and osteogenic gene expression in cultured mouse osteoblastic MC3T3-E1 cells by using alkaline phosphatase (ALP) activity analysis, alizarin red S staining and real-time PCR assay. RESULTS: ALP activity and alizarin red S staining analyses demonstrated no significant difference between differentiating MC3T3-E1 cells cultured in the presence of phosvitin and those cultured in the presence of ascorbic acid after 21 days of differentiation...
March 23, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28332131/biostimulation-with-diode-laser-positively-regulates-cementoblast-functions-in-vitro
#11
Serife Buket Bozkurt, Erdogan E Hakki, Seyit Ali Kayis, Niyazi Dundar, Sema S Hakki
The aim of this study was to evaluate the effects of diode laser biostimulation on cementoblasts (OCCM.30). A total of 40 root plates were obtained from healthy third molar teeth and assigned to the following two groups: (1) control group and (2) laser-treated group. Root plates were placed into the cell culture inserts, and OCCM.30 cells were seeded onto root plates. Cells were irradiated with a low level of diode laser (power: 0.3 W in continuous wave, 60 s/cm(2)). Proliferation and mineralized tissue-associated gene's and BMP's messenger RNA (mRNA) expressions of cementoblasts were evaluated...
March 22, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/28331906/associations-between-sarcopenia-and-degenerative-lumbar-scoliosis-in-older-women
#12
Yawara Eguchi, Munetaka Suzuki, Hajime Yamanaka, Hiroshi Tamai, Tatsuya Kobayashi, Sumihisa Orita, Kazuyo Yamauchi, Miyako Suzuki, Kazuhide Inage, Kazuki Fujimoto, Hirohito Kanamoto, Koki Abe, Yasuchika Aoki, Tomoaki Toyone, Tomoyuki Ozawa, Kazuhisa Takahashi, Seiji Ohtori
BACKGROUND: Age-related sarcopenia can cause various forms of physical disabilities. We investigated how sarcopenia affects degenerative lumbar scoliosis (DLS) and lumbar spinal canal stenosis (LSCS). METHODS: Subjects comprised 40 elderly women (mean age 74 years) with spinal disease whose chief complaints were low back pain and lower limb pain. They included 15 cases of DLS (mean 74.8 years) and 25 cases of LSCS (mean age 72.9 years). We performed whole-body dual-energy X-ray absorptiometry (DXA) to analyze body composition, including appendicular and trunk skeletal muscle mass index (SMI; lean mass (kg)/height (m)(2)) and bone mineral density (BMD)...
2017: Scoliosis and Spinal Disorders
https://www.readbyqxmd.com/read/28331747/the-relationship-between-bone-mineral-density-and-estrogen-receptor-positivity-in-patients-with-breast-cancer
#13
Zeynep Erdoğan İyigün, Kezban Nur Pilancı, Fatmagül Kuşku Çabuk, Serkan İlgün, Çetin Ordu, Tomris Duymaz, Gül Alço, Filiz Çelebi, Dauren Sarsenov, Filiz İzci, Alper Öztürk, Filiz Ağaçayak, Ülkühan İner Köksal, Fatma Aktepe, Yeşim Eralp, Vahit Özmen
OBJECTIVE: The effect of estrogen on bone mineral density (BMD) and breast cancer has been known for a long time. The aim of this study was to compare of the BMD of patients with breast cancer and healthy individuals, and to investigate the degree of correlation of estrogen receptor (ER) with BMD. MATERIALS AND METHODS: Seventy-one patients with postmenopausal breast cancer and 79 healthy dividuals were included in the study. The patient demographics (age, menopause age, body mass index, number of children, BMD, Z scores, and estrogen status for breast cancer patients) were taken from hospital records...
July 2016: J Breast Health (2013)
https://www.readbyqxmd.com/read/28330908/the-effect-of-dairy-intake-on-bone-mass-and-body-composition-in-early-pubertal-girls-and-boys-a-randomized-controlled-trial
#14
Kara A Vogel, Berdine R Martin, Linda D McCabe, Munro Peacock, Stuart J Warden, George P McCabe, Connie M Weaver
Background: Calcium retention increases with increasing body mass index (BMI) on recommended calcium intakes. Dairy foods are an excellent source of essential nutrients that are needed to increase bone mineral content (BMC) and potentially decrease fracture.Objective: We compared children who were overweight with children who were healthy weight for the accrual of bone mass in response to an extra 3 servings dairy/d compared with usual intake.Design: Participants were 240 healthy boys and girls (64%), aged 8-15...
March 22, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28329121/very-low-calorie-diets-for-weight-loss-in-obese-older-adults-a-randomized-trial
#15
Cilla J Haywood, Luke A Prendergast, Katrina Purcell, Lauren Le Fevre, Wen Kwang Lim, Mary Galea, Joseph Proietto
Background: Obesity contributes to disability in older adults, and this is offset by weight loss and exercise. Very Low Calorie Diets (VLCDs) achieve rapid weight loss; however, these have not been rigorously evaluated in older people. Methods: A randomized trial was conducted from August 2012 through December 2015. The intervention was 12 weeks of thrice weekly exercise combined with either healthy eating advice (Ex/HE), hypocaloric diet (Ex/Diet), or VLCD (Ex/VLCD)...
February 20, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28328853/updated-association-of-tea-consumption-and-bone-mineral-density-a-meta-analysis
#16
Zhao-Fei Zhang, Jun-Long Yang, Huan-Chang Jiang, Zheng Lai, Feng Wu, Zhi-Xiang Liu
BACKGROUND: Current studies evaluating the association of tea consumption and bone mineral density (BMD) have yielded inconsistent findings. Therefore, we conducted a meta-analysis to assess the relationship between tea consumption and BMD. METHODS: The PubMed, Embase, and Cochrane Library databases were comprehensively searched, and a meta-analysis performed of all observational studies assessing the association of tea consumption and BMD. Forest plots were used to illustrate the results graphically...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28328298/the-synthetic-progestin-gestodene-affects-functional-biomarkers-in-neonatal-rat-osteoblasts-through-an-estrogen-receptor-related-mechanism-of-action
#17
Juana Enríquez, Gustavo García, Bertha Herrero, Fernando Larrea
BACKGROUND: Clinical studies have shown that gestodene (GDN), a potent third-generation synthetic progestin, affects bone resorption. However, its mode of action in bone cells is not fully understood. The aim of this study was to establish whether GDN affects bone directly or through its bioconversion to other metabolites with different biological activities. METHODS: In this study, we investigated the effects of GDN and its A-ring reduced metabolites on proliferation, differentiation, and mineralization of calvarial osteoblasts isolated from neonatal rat and their capacity to displace [(3)H]-E2 at ER binding sites...
March 22, 2017: Endocrine Research
https://www.readbyqxmd.com/read/28327602/glucocorticoid-suppression-of-osteocyte-perilacunar-remodeling-is-associated-with-subchondral-bone-degeneration-in-osteonecrosis
#18
Tristan W Fowler, Claire Acevedo, Courtney M Mazur, Faith Hall-Glenn, Aaron J Fields, Hrishikesh A Bale, Robert O Ritchie, Jeffrey C Lotz, Thomas P Vail, Tamara Alliston
Through a process called perilacunar remodeling, bone-embedded osteocytes dynamically resorb and replace the surrounding perilacunar bone matrix to maintain mineral homeostasis. The vital canalicular networks required for osteocyte nourishment and communication, as well as the exquisitely organized bone extracellular matrix, also depend upon perilacunar remodeling. Nonetheless, many questions remain about the regulation of perilacunar remodeling and its role in skeletal disease. Here, we find that suppression of osteocyte-driven perilacunar remodeling, a fundamental cellular mechanism, plays a critical role in the glucocorticoid-induced osteonecrosis...
March 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28327260/vitamin-d-and-dental-caries-in-primary-dentition
#19
Ana Lucia Seminario, Elizabet Velan
Traditionally classified as a vitamin, vitamin D represents a group of fat-soluble secosteroids with D2 (ergocalciferol) and D3 (cholecalciferol) being the most relevant of the group. The importance of this prohormone exceeds its known ability to maintain intra- and extracellular calcium and phosphate concentrations, thereby preserving essential metabolic functions such as the promotion of mineralization and maintenance and remodeling of the bone. Current observational research recognizes the potential antiproliferative, prodifferentiative, and immunomodulatory effects of vitamin D and its metabolites in the human body...
September 15, 2016: Journal of Dentistry for Children
https://www.readbyqxmd.com/read/28327171/the-association-of-time-and-medications-with-changes-in-bone-mineral-density-in-the-2%C3%A2-years-after-critical-illness
#20
Neil R Orford, Michael Bailey, Rinaldo Bellomo, Julie A Pasco, Claire Cattigan, Tania Elderkin, Sharon L Brennan-Olsen, David J Cooper, Mark A Kotowicz
BACKGROUND: Critical illness is associated with increased risk of fragility fracture and loss of bone mineral density (BMD), although the impact of medication exposures (bone anti-fracture therapy or glucocorticoids) and time remain unexplored. The objective of this study was to describe the association of time after ICU admission, and post-ICU administration of bone anti-fracture therapy or glucocorticoids after critical illness, with change in BMD. METHODS: In this prospective observational study, conducted in a tertiary hospital ICU, we studied adult patients requiring mechanical ventilation for at least 24 hours and measured BMD annually for 2 years after ICU discharge...
March 21, 2017: Critical Care: the Official Journal of the Critical Care Forum
keyword
keyword
18918
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"