keyword
MENU ▼
Read by QxMD icon Read
search

Bone and mineral

keyword
https://www.readbyqxmd.com/read/29334399/chondrocyte-burst-promotes-space-for-mineral-expansion
#1
Emilio Satoshi Hara, Masahiro Okada, Noriyuki Nagaoka, Takako Hattori, Letycia Mary Iida, Takuo Kuboki, Takayoshi Nakano, Takuya Matsumoto
Analysis of tissue development from multidisciplinary approaches can result in more integrative biological findings, and can eventually allow the development of more effective bioengineering methods. In this study, we analyzed the initial steps of mineral formation during secondary ossification of mouse femur based on biological and bioengineering approaches. We first found that some chondrocytes burst near the mineralized area. External factors that could trigger chondrocyte burst were then investigated. Chondrocyte burst was shown to be modulated by mechanical and osmotic pressure...
January 15, 2018: Integrative Biology: Quantitative Biosciences From Nano to Macro
https://www.readbyqxmd.com/read/29333323/alveolar-ridge-preservation-with-an-open-healing-approach-using-single-layer-or-double-layer-coverage-with-collagen-membranes
#2
Ho-Keun Choi, Hag-Yeon Cho, Sung-Jo Lee, In-Woo Cho, Hyun-Seung Shin, Ki-Tae Koo, Hyun-Chang Lim, Jung-Chul Park
Purpose: The aim of this prospective pilot study was to compare alveolar ridge preservation (ARP) procedures with open-healing approach using a single-layer and a double-layer coverage with collagen membranes using radiographic and clinical analyses. Methods: Eleven molars from 9 healthy patients requiring extraction of the maxillary or mandibular posterior teeth were included and allocated into 2 groups. After tooth extraction, deproteinized bovine bone mineral mixed with 10% collagen was grafted into the socket and covered either with a double-layer of resorbable non-cross-linked collagen membranes (DL group, n=6) or with a single-layer (SL group, n=5)...
December 2017: Journal of Periodontal & Implant Science
https://www.readbyqxmd.com/read/29332861/epicardial-fat-thickness-and-bone-mineral-content-the-healthy-twin-study-in-korea
#3
Dong-Won Lee, Min Soo Cho, Eun Yeong Choe, Seung Woo Park, Yun-Mi Song, Sang-Chol Lee, Joohon Sung
BACKGROUND: The conventional concept of positive association between general obesity and bone health was challenged in recent studies reporting the different effects of specific fat deposition on bone health. In the present study, we investigated the association between epicardial fat and bone health. METHODS: We measured echocardiographic epicardial fat thickness (EFT) and bone mineral content (BMC) in a twin-family cohort of Koreans (n = 1,198; 525 men, 460 pre- and 213 post-menopausal women)...
January 13, 2018: Journal of Epidemiology
https://www.readbyqxmd.com/read/29332174/a-friend-in-knee-ccn3-may-inhibit-osteoarthritis-progression
#4
Alex Peidl
Osteoarthritis (OA) is a major clinical problem among the ageing population, yet no disease-modifying treatments currently exist. This issue arises, in part, due to the complex processes occurring in the microenvironment of articular cartilage that lead to osteoarthritic changes. Gaining a better understanding of these processes is crucial in developing a viable therapy for OA. A recent report in Journal of Bone Mineral Metabolism by Janune et al. (J Bone Miner Metab 35:582-597, 2016) suggests a novel role for CCN3 in maintaining the differentiated phenotype of articular cartilage...
January 13, 2018: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/29332162/roles-of-irisin-in-the-linkage-from-muscle-to-bone-during-mechanical-unloading-in-mice
#5
Naoyuki Kawao, Akihiro Moritake, Kohei Tatsumi, Hiroshi Kaji
Mechanical unloading induces disuse muscle atrophy and bone loss, but the details in mechanism involved in those pathophysiological conditions are not fully understood. Interaction between muscle and bone has been recently noted. Here, we investigated the roles of humoral factors linking muscle to bone during mechanical unloading using mice with hindlimb unloading (HU) and sciatic neurectomy (SNX). HU and SNX reduced muscle volume surrounding the tibia, tissue weights of soleus and gastrocnemius muscle, and trabecular bone mineral density (BMD) in the tibia of mice...
January 13, 2018: Calcified Tissue International
https://www.readbyqxmd.com/read/29331722/effect-of-vitamin-d-supplementation-on-serum-sclerostin-levels-in-chronic-kidney-disease
#6
REVIEW
Ashok Kumar Yadav, Vivek Kumar, Debasish Banerjee, Krishan Lal Gupta, Vivekanand Jha
Vitamin D deficiency, cardiovascular disease and abnormal bone mineral metabolism are common in chronic kidney disease (CKD). Abnormal bone mineral metabolism has been linked to vascular calcification in CKD. Sclerostin has emerged as an important messenger in cross talk between bone-vascular axis. We analyzed sclerostin in subjects who participated in the randomized, double blind, placebo controlled trial investigating the effect of cholecalciferol supplementation on vascular function in non-diabetic CKD stage G3-4 and vitamin D ≤20ng/ml [CTRI/2013/05/003648]...
January 10, 2018: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/29331397/persistent-hyperparathyroidism-as-a-risk-factor-for-long-term-graft-failure-the-need-to-discuss-indication-for-parathyroidectomy
#7
Maria Júlia Correia Lima Nepomuceno Araujo, Janaina Almeida Mota Ramalho, Rosilene Motta Elias, Vanda Jorgetti, William Nahas, Melani Custodio, Rosa M A Moysés, Elias David-Neto
BACKGROUND: Although a successful kidney transplant (KTx) improves most of the mineral and bone disorders (MBD) produced by chronic kidney disease (CKD), hyperparathyroidism may persist (pHPT). Current guidelines recommend parathyroidectomy if serum parathormone is persistently elevated 1 year after KTx, because pHPT has been recently associated with poor graft outcomes. However, whether patients with pHPT and adequate renal function are at risk for long-term graft failure is unknown...
January 10, 2018: Surgery
https://www.readbyqxmd.com/read/29331301/marrow-adipose-tissue-imaging-in-humans
#8
Vibha Singhal, Miriam A Bredella
Bone strength is affected not only by bone mineral density (BMD) and bone microarchitecture but also its microenvironment. Recent studies have focused on the role of marrow adipose tissue (MAT) in the pathogenesis of bone loss. Osteoblasts and adipocytes arise from a common mesenchymal stem cell within bone marrow and many osteoporotic states, including aging, medication use, immobility, over - and undernutrition are associated with increased marrow adiposity. Advancements in imaging technology allow the non-invasive quantification of MAT...
January 10, 2018: Bone
https://www.readbyqxmd.com/read/29331300/cigarette-smoking-and-hip-volumetric-bone-mineral-density-and-cortical-volume-loss-in-older-adults-the-ages-reykjavik-study
#9
Elisa A Marques, Martine Elbejjani, Vilmundur Gudnason, Gunnar Sigurdsson, Thomas Lang, Sigurdur Sigurdsson, Thor Aspelund, Kristin Siggeirsdottir, Lenore Launer, Gudny Eiriksdottir, Tamara B Harris
This study aimed to explore the relationships of several indicators of cigarette smoking habits (smoking status, pack-years, age at smoking initiation and smoking cessation) with quantitative computed tomographic (QCT)-derived proximal femur bone measures (trabecular vBMD, integral vBMD and the ratio of cortical to total tissue volume (cvol/ivol)) and with subsequent change in these measures over the next five years. A total of 2673 older adults (55.9% women), aged 66-92 years at baseline from the Age, Gene/Environment Susceptibility (AGES)-Reykjavik Study, who had two QCT scans of the hip were studied...
January 10, 2018: Bone
https://www.readbyqxmd.com/read/29331041/effect-of-low-level-laser-therapy-on-the-healing-of-sites-grafted-with-coagulum-deproteinized-bovine-bone-and-biphasic-ceramic-made-of-hydroxyapatite-and-%C3%AE-tricalcium-phosphate-in-vivo-study-in-rats
#10
Guilherme J P L de Oliveira, Maurício A T Aroni, Marcell C Medeiros, Elcio Marcantonio, Rosemary A C Marcantonio
OBJECTIVE: The aim of this study was to evaluate the effect of low-level laser therapy (LLLT) on the healing of biomaterial graft areas (i.e., coagulum, deproteinized bovine bone, and biphasic ceramics comprising hydroxyapatite and β-tricalcium phosphate). MATERIAL AND METHODS: Ninety rats were divided into two groups according to laser irradiation use (λ 808 nm, 100 mW, φ ∼600 μm, seven sessions with 28 J of irradiation dose in total): a laser group and a control group...
January 13, 2018: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/29330572/effects-of-whole-body-vibration-on-muscle-strength-bone-mineral-content-and-density-and-balance-and-body-composition-of-children-and-adolescents-with-down-syndrome-a-systematic-review
#11
REVIEW
M B Saquetto, F F Pereira, R S Queiroz, C M da Silva, C S Conceição, M Gomes Neto
The aim of this study is to verify the effects of whole-body vibration (WBV) training on the muscle strength of children and adolescents with Down syndrome. We searched MEDLINE, Cochrane, SciELO, Lilacs and PUBMED databases and included manual searches to identify randomised controlled trials to investigate the effects of WBV on the structure and body function of children and adolescents with Down syndrome. Two reviewers independently selected the studies and performed statistical analysis. In total, five studies with 171 patients that compared WBV with exercise and/or control were included...
January 12, 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29330445/a-novel-approach-for-correction-of-crosstalk-effects-in-pathway-analysis-and-its-application-in-osteoporosis-research
#12
Yu Zhou, Yunlong Gao, Chao Xu, Hui Shen, Qing Tian, Hong-Wen Deng
Osteoporosis is a prevalent bone metabolic disease and peripheral blood monocytes represent a major systemic cell type for bone metabolism. To identify the key dysfunctional pathways in osteoporosis, we performed pathway analyses on microarray data of monocytes from subjects with extremely high/low hip bone mineral density. We first performed a traditional pathway analysis for which different pathways were treated as independent. However, genes overlap among pathways will lead to "crosstalk" phenomenon, which may lead to false positive/negative results...
January 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29329805/preparative-expression-and-purification-of-a-nacreous-protein-n16-and-testing-its-effect-on-osteoporosis-rat-model
#13
Zhen-Yan Xu, Yu-Ling Liu, Jia-Bi Lin, Ke-Ling Cheng, Yong-Gang Wang, Hong-Liang Yao, Wei-Peng, Hoi-Yan Wu, Wei-Wei Su, Pang-Chui Shaw, Pei-Bo Li
N16, a nacreous protein isolated from Pinctada martensii, is related to nacreous layer formation. Our previous study indicated that N16 showed dual regulatory effects by inducing osteoblast biomineralization as well as inhibiting osteoclast formation. In order to obtain large quantity of N16 for animal experiment and clinical trial, a fermentation and preparative purification method was established. The N16 cDNA was cloned to a BL21(DE3)plysE-pET32a vector and grown in a 20 L fermenter. The medium, temperature, pH and dissolved oxygen (DO) were optimized...
January 9, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29329765/usefulness-of-the-trabecular-bone-score-for-assessing-the-risk-of-osteoporotic-fracture
#14
L Redondo, E Puigoriol, J R Rodríguez, P Peris, E Kanterewicz
INTRODUCTION AND OBJECTIVES: The trabecular bone score (TBS) is an imaging technique that assesses the condition of the trabecular microarchitecture. Preliminary results suggest that TBS, along with the bone mineral density assessment, could improve the calculation of the osteoporotic fracture risk. The aim of this study was to analyse TBS values and their relationship with the clinical characteristics, bone mineral density and history of fractures of a cohort of posmenopausal women. MATERIAL AND METHODS: We analysed 2,257 posmenopausal women from the FRODOS cohort, which was created to determine the risk factors for osteoporotic fracture through a clinical survey and bone densitometry with vertebral morphometry...
January 9, 2018: Revista Clínica Española
https://www.readbyqxmd.com/read/29329716/gelatin-hydroxyapatite-calcium-sulphate-based-biomaterial-for-long-term-sustained-delivery-of-bone-morphogenic-protein-2-and-zoledronic-acid-for-increased-bone-formation-in-vitro-and-in-vivo-carrier-properties
#15
Deepak Bushan Raina, David Larsson, Filip Mrkonjic, Hanna Isaksson, Ashok Kumar, Lars Lidgren, Magnus Tägil
In this study, a novel macroporous composite biomaterial consisting of gelatin-hydroxyapatite-calcium sulphate for delivery of bone morphogenic protein-2 (rhBMP-2) and zoledronic acid (ZA) has been developed. The biomaterial scaffold has a porous structure and functionalization of the scaffold with rhBMP-2 induces osteogenic differentiation of MC3T3-e1 cells seen by a significant increase in biochemical and genetic markers of osteoblastic differentiation. In-vivo muscle pouch experiments showed higher mineralization using scaffold+rhBMP-2 when compared to an approved absorbable collagen sponge (ACS)+rhBMP-2 as verified by micro-CT...
January 9, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29329487/a-history-of-pivotal-advances-in-clinical-research-into-bone-and-mineral-diseases
#16
EDITORIAL
Steven R Cummings, Richard Eastell
No abstract text is available yet for this article.
January 12, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29329467/low-aromatase-activity-and-estradiol-sex-hormone-binding-globulin-ratio-are-associated-with-total-hip-bone-mineral-density-and-the-presence-of-osteoporosis-a-study-in-chinese-postmenopausal-women
#17
Hai-Juan Liu, Jun Yan, Yan Li, Fang-Yuan Zhou, Xu-Dong Su, Hui-Jing Fan, Jie Bai, Guang-Zhen Zhang
Several groups have reported the important role of estradiol (E2) and testosterone (T) in postmenopausal osteoporosis (PMOP). Because aromatase catalyzes the conversion of T to E2, the purpose of this study was to determine the influence of aromatase activity on the bone mineral density (BMD) in postmenopausal women. A total of 344 postmenopausal women were selected for this study. Serum E2, T, sex hormone-binding globulin (SHBG), calcium (Ca), alkaline phosphatase (ALP), C-terminal telopeptide of type I collagen (CTX), and procollagen type I amino-terminal propeptide (PINP) were examined...
January 2018: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/29329430/increases-in-igf-1-after-anti-tnf-%C3%AE-therapy-are-associated-with-bone-and-muscle-accrual-in-pediatric-crohn-s-disease
#18
Mark D DeBoer, Arthur M Lee, Kirabo Herbert, Jin Long, Meena Thayu, Lindsay M Griffin, Robert N Baldassano, Lee A Denson, Babette S Zemel, Michelle R Denburg, Rita Herskovitz, Mary B Leonard
Context: Low levels of IGF-1 in pediatric and adolescent Crohn's Disease (CD) likely contribute to bone and muscle deficits. Objective: Assess changes in IGF-1 levels and associations with bone and muscle accrual following initiation of anti-TNF-α therapy in pediatric and adolescent CD. Design and Participants: Participants (n=75, age 5-21 years) with CD were enrolled in a prospective cohort study; 63 completed the 12-month visit. Main Outcome Measures: IGF-1 levels at baseline and 10 weeks, and DXA and tibia peripheral quantitative-CT (pQCT) measures of bone and muscle at baseline and 12 months after initiation of anti-TNF-α therapy...
January 10, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29328885/radiographic-emphysema-circulating-bone-biomarkers-and-progressive-bone-mineral-density-loss-in-smokers
#19
Jessica Bon, Yingze Zhang, Joseph K Leader, Carl Fuhrman, Subashan Perera, Divay Chandra, Marnie Bertolet, Brenda Diergaarde, Susan L Greenspan, Frank C Sciurba
RATIONALE: Osteoporosis is common in individuals with chronic obstructive pulmonary disease. Lung-specific factors, including radiographic emphysema, independently associate with low bone mineral density (BMD) in cross-sectional smoking cohorts. However, factors associated with progressive bone loss in smokers are under-studied and largely unknown. OBJECTIVES: To determine the relationship between radiographic emphysema, circulating bone metabolism markers, and pulmonary function and accelerated BMD loss in smokers...
January 12, 2018: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/29328519/surface-modification-using-the-biomimetic-method-in-alumina-zirconia-porous-ceramics-obtained-by-the-replica-method
#20
André D R Silva, Willian R Rigoli, Denise Osiro, Daphne C R Mello, Luana M R Vasconcellos, Anderson O Lobo, Eliria M J A Pallone
The modification of biomaterials approved by the Food and Drug Administration could be an alternative to reduce the period of use in humans. Porous bioceramics are widely used as support structures for bone formation and repair. This composite has essential characteristics for an implant, including good mechanical properties, high chemical stability, biocompatibility and adequate aesthetic appearance. Here, three-dimensional porous scaffolds of Al2 O3 containing 5% by volume of ZrO2 were produced by the replica method...
January 12, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
keyword
keyword
18918
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"