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https://www.readbyqxmd.com/read/28525533/phenol-concentrations-during-childhood-and-subsequent-measures-of-adiposity-among-young-girls
#1
Andrea L Deierlein, Mary S Wolff, Ashley Pajak, Susan M Pinney, Gayle C Windham, Maida P Galvez, Michael Rybak, Antonia M Calafat, Lawrence H Kushi, Frank M Biro, Susan L Teitelbaum
Phenolic compounds represent a class of environmental chemicals with potential endocrine disrupting capabilities. We investigated longitudinal associations of childhood exposures to phenols, from both man-made and natural sources, and subsequent measures of adiposity among girls enrolled in The Breast Cancer and Environment Research Program, 2004-2007. Baseline (ages 6-8 years) urinary concentrations were obtained for creatinine and phenol metabolites: enterolactone, genistein, daidzein, benzophenone-3, bisphenol A, sum of parabens (methyl, ethyl, and propyl parabens), 2,5-dichlorophenol, and triclosan...
May 19, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28523418/breast-cancer-and-exposure-to-tobacco-smoke-during-potential-windows-of-susceptibility
#2
Alexandra J White, Aimee A D'Aloisio, Hazel B Nichols, Lisa A DeRoo, Dale P Sandler
PURPOSE: An association between smoking and breast cancer is unresolved, although a higher risk from exposure during windows of susceptibility has been proposed. The objective of this prospective study was to evaluate the association between tobacco smoke and breast cancer with a focus on timing of exposure, especially during early life. METHODS: Sister study participants (n = 50,884) aged 35-74 were enrolled from 2003 to 2009. Women in the United States and Puerto Rico were eligible if they were breast cancer-free but had a sister with breast cancer...
May 18, 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28508614/methods-for-rating-sexual-development-in-girls
#3
Vincenzo De Sanctis, Ihab Zaki Elhakim, Ashraf T Soliman, Heba Elsedfy, Rania Elalaily, Giuseppe Millimaggi
Sexual maturity rating (SMR) is important in population studies and in clinical care. Pubertal staging allows doctors to assess the maturation of adolescents to correlate several pubertal phenomena such as age at menarche, growth spurt and final height, to advise and manage patients appropriately and to have sensitive "sensors" of the effects of environmental exposure on human populations. The commonly used markers of the timing of female puberty are thelarche and menarche. Appearance of the breast bud is the first indicator of puberty onset in 90% of girls...
September 2016: Pediatric Endocrinology Reviews: PER
https://www.readbyqxmd.com/read/28499525/consecutive-cyproterone-acetate-and-estradiol-treatment-in-late-pubertal-transgender-female-adolescents
#4
Lloyd J W Tack, Robin Heyse, Margarita Craen, Karlien Dhondt, Heidi Vanden Bossche, Jolien Laridaen, Martine Cools
BACKGROUND: Cyproterone acetate (CA) is an antiandrogenic progestin commonly used in adult transwomen to suppress endogenous androgens, often in combination with estrogens to induce feminization. AIM: To assess the (side) effects and biochemical changes of CA alone and in combination with estrogens in adolescent trans-girls. METHODS: This study was a retrospective analysis of clinical and biochemical data from 27 trans-girls who presented at Tanner stage G4 and were treated with CA monotherapy for at least 6 months (mean = 12 months) and then in combination with incremental doses of estrogens (CA + E; mean = 16 months)...
May 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/28499444/a-french-national-breast-and-thyroid-cancer-screening-programme-for-survivors-of-childhood-adolescent-and-young-adult-caya-cancers-denacapst-programme
#5
Charlotte Demoor-Goldschmidt, Delphine Drui, Isabelle Doutriaux, Gérard Michel, Pascal Auquier, Agnès Dumas, Claire Berger, Valérie Bernier, Sandrine Bohrer, Pierre-Yves Bondiau, Bruno Filhon, Brice Fresneau, Claire Freycon, Dinu Stefan, Sylvie Helfre, Angela Jackson, Christine Kerr, Anne Laprie, Julie Leseur, Marc-André Mahé, Caroline Oudot, Claire Pluchard, Stéphanie Proust, Hélène Sudour-Bonnange, Céline Vigneron, Nathalie Lassau, Martin Schlumberger, Cécile Faure Conter, Florent de Vathaire
BACKGROUND: Survival of childhood, adolescent and young adult (CAYA) cancers has increased with progress in the management of the treatments and has reached more than 80% at 5 years. Nevertheless, these survivors are at great risk of second cancers and non-malignant co-morbidities in later life. DeNaCaPST is a non-interventional study whose aim is to organize a national screening for thyroid cancer and breast cancer in survivors of CAYA cancers. It will study the compliance with international recommendations, with the aim, regarding a breast screening programme, of offering for every woman living in France, at equal risk, an equal screening...
May 12, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28464176/breast-feeding-leptin-adiponectin-ratio-and-metabolic-dysfunction-in-adolescents-with-obesity
#6
Nicole L Mihalopoulos, Brittney M Urban, Julie M Metos, Alfred H Balch, Paul C Young, Kristine C Jordan
OBJECTIVES: Increased adiposity increases leptin and decreases adiponectin concentrations, resulting in an increased leptin:adiponectin ratio (LAR). In adults, components of the metabolic syndrome and other cardiometabolic risk factors, what we classify here as "metabolic dysfunction," are associated with both a high LAR and a history of being breast-fed. The relation among breast-feeding, LAR, and degree of metabolic dysfunction in obese youth is unknown. The purpose of our pilot study was to explore this relation and estimate the effect size of the relations to determine the sample size needed to power future prospective studies...
May 2017: Southern Medical Journal
https://www.readbyqxmd.com/read/28458828/giant-phyllodes-tumor-of-the-breast-with-diffuse-myxoid-changes-in-an-adolescent-girl-a-case-report
#7
Ji Young Lee
Giant phyllodes tumors (PT) are an uncommon fibroepithelial neoplasm and especially rare in adolescent girls. Diagnosis is difficult not only due to the rarity of PT, but also owing to the resemblance of its clinical and imaging features with fibroadenoma. The author reports a case of a giant PT in a 14-year-old girl. Clinical examination showed a large painful mass in the left breast, and an abscess was initially suspected. But magnetic resonance imaging (MRI) displayed features characteristic of PT. Following complete surgical excision of the mass, histopathology confirmed the diagnosis of a benign PT with diffuse myxoid changes, consistent with the MRI findings...
February 2017: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/28455130/a-nonsurgical-approach-to-adolescent-breast-asymmetry-using-external-prostheses
#8
Carolyn M Pike, Joseph M Firriolo, Nicole C Ontiveros, Sarada P Kuchibhotla, Olivia K Oppel, Lauren C Monoxelos, Arin K Greene, Brian I Labow
PURPOSE: Currently, there are few nonsurgical treatment options for pediatric patients with developmental breast asymmetry. Our group established a partnership with a prosthetic unit within a local oncology center to provide custom-fit breast prostheses for young women with breast asymmetry. The purpose of this study was to describe the effect of this experience on patients' self-esteem and body image. METHODS: Patients were administered an anonymous satisfaction survey at least 1 month after their first fitting at the prosthetic unit...
April 25, 2017: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
https://www.readbyqxmd.com/read/28451801/the-characteristics-and-short-term-surgical-outcomes-of-adolescent-gynecomastia
#9
Byung Seo Choi, Sung Ryul Lee, Geon Young Byun, Seong Bae Hwang, Bum Hwan Koo
BACKGROUND: Most adolescent gynecomastia is resolved spontaneously in 3 years. But, persistent gynecomastia could have a negative influence on psychoemotional development on adolescence. The purpose of this study is to report the characteristics of adolescent gynecomastia patients who received the surgeries, and discuss the short-term surgical outcomes. METHODS: Of the 1454 patients who underwent gynecomastia surgery at Damsoyu hospital from January 2014 to May 2016, 71 were adolescents...
April 27, 2017: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/28449957/assessment-of-breast-asymmetry-in-adolescent-idiopathic-scoliosis-using-an-automated-3d-body-surface-measurement-technique
#10
Joyce Ramsay, Lama Seoud, Soraya Barchi, Farida Cheriet, Julie Joncas, Isabelle Turgeon, Philippe Debanné, Isabelle Trop, Hubert Labelle, Stefan Parent
STUDY DESIGN: Cohort study. OBJECTIVES: To assess breast asymmetry (BA) directly with 3D surface imaging and to validate it using MRI values from a cohort of 30 patients with significant adolescent idiopathic scoliosis (AIS). Also, to study the influence of posture (prone vs standing) on BA using the automated method on both modalities. SUMMARY OF BACKGROUND DATA: BA is a common concern in young female patients with AIS. In a previous study using MRI, we found that the majority of patients with significant AIS experienced BA of up to 21% in addition to their chest wall deformity...
May 2017: Spine Deformity
https://www.readbyqxmd.com/read/28438374/validity-of-self-assessed-sexual-maturation-against-physician-assessments-and-hormone-levels
#11
Jorge E Chavarro, Deborah J Watkins, Myriam C Afeiche, Zhenzhen Zhang, Brisa N Sánchez, David Cantonwine, Adriana Mercado-García, Clara Blank-Goldenberg, John D Meeker, Martha María Téllez-Rojo, Karen E Peterson
OBJECTIVE: To compare self-report and physician assessments of sexual maturation against serum hormone markers to evaluate the hypothesis that the validity of self-assessed sexual maturation is underestimated in traditional validation studies. STUDY DESIGN: We adapted a self-assessment instrument that 248 Mexican children and adolescents, aged 8-13 years, completed. The participants were examined by a trained pediatrician and provided fasting blood samples for measurement of reproductive hormones (eg, testosterone, estradiol, sex hormone-binding globulin, inhibin B) and other hormones (eg, C-peptide, insulin-like growth factor 1, leptin, dehydroepiandrosterone sulfate) known to change during adolescence...
April 21, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28437336/both-bilateral-breast-volume-discrepancy-and-asymmetric-anterior-chest-wall-shape-contribute-to-the-unsightly-breast-contour-in-female-right-thoracic-idiopathic-scoliosis
#12
Benlong Shi, Saihu Mao, Xu Sun, Leilei Xu, Feng Zhu, Zezhang Zhu, Bangping Qian, Weijun Wang, Yong Qiu
STUDY DESIGN: A retrospective radiographic study. OBJECTIVE: To evaluate the asymmetry of breast volume (BV) and shape in female adolescent idiopathic scoliosis (AIS) patients and to define their relationship with deformed components of the anterior chest wall and curved spine. SUMMARY OF BACKGROUND DATA: The higher incidence of asymmetric breast development in AIS was described by prior studies. However, the interplay between scoliosis curve magnitude and severity of breast asymmetry (BA) are unknown...
May 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28426850/second-primary-malignant-neoplasms-and-survival-in-adolescent-and-young-adult-cancer-survivors
#13
Theresa H M Keegan, Archie Bleyer, Aaron S Rosenberg, Qian Li, Melanie Goldfarb
Importance: Although the increased incidence of second primary malignant neoplasms (SPMs) is a well-known late effect after cancer, few studies have compared survival after an SPM to survival of the same cancer occurring as first primary malignant neoplasm (PM) by age. Objective: To assess the survival impact of SPMs in adolescents and young adults (AYAs) (15-39 years) compared with that of pediatric (<15 years) and older adult (≥40 years) patients with the same SPMs...
April 20, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28419243/the-efficacy-and-safety-of-pubertal-induction-using-17beta-estradiol-in-transgirls
#14
Sabine E Hannema, Sebastian E E Schagen, Peggy T Cohen-Kettenis, Henriette A Delemarre-van de Waal
Introduction.: Puberty suppression using GnRH agonists, followed by induction of desired sex characteristics using sex steroids, is recommended by current guidelines as the treatment of choice for gender dysphoric adolescents although little evidence is available. Aim.: To evaluate the efficacy and safety of estrogen treatment for pubertal induction in transgirls (female-identifying adolescents assigned male at birth). Methods.: 28 Adolescents treated with oral estrogen for at least 1 year were included...
April 14, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28403086/a-case-report-of-apatinib-in-treating-osteosarcoma-with-pulmonary-metastases
#15
Yong Zhou, Wengeng Zhang, Fan Tang, Yi Luo, Li Min, Wenli Zhang, Rui Shi, Hong Duan, Chongqi Tu
RATIONALE: Osteosarcoma is the most common malignant bone tumor in children and adolescents. Pulmonary metastases lead to a significantly increased risk of death. Apatinib, a new potent oral small-molecule tyrosine kinase inhibitor targeting the intracellular domain of vascular endothelial growth factor receptor 2 (VEGFR-2), shows survival benefits in treating advanced or metastatic gastric adenocarcinoma, non-squamous non-small cell lung cancer and metastatic breast cancer. However, its efficacy in metastatic osteosarcoma has not been reported yet...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28398472/safety-of-cosmetic-surgery-in-adolescent-patients
#16
Max Yeslev, Varun Gupta, Julian Winocour, R Bruce Shack, James C Grotting, K Kye Higdon
Background: Limited surgical literature currently exists that evaluates postoperative complications after cosmetic surgery in adolescents. Objectives: The purpose of this study was to determine the incidence of major postoperative complications in adolescent patients undergoing cosmetic surgery and compare their complication rates to older patients. Methods: A prospective cohort of patients undergoing cosmetic surgical procedures between 2008 and 2013 was identified from the CosmetAssure database...
April 7, 2017: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/28362651/breast-cancer-education-for-schoolgirls-an-exploratory-study
#17
Nicola Brown, Jenny Smith, Amanda Brasher, Atefeh Omrani, Joanna Wakefield-Scurr
Adolescent girls are an important target group for breast cancer education and promoting breast awareness. However, research has not established schoolgirls' perceived importance of breast cancer education or explored factors that may impact engagement. This study aimed to identify schoolgirls' concerns about breast cancer, desire to know more and perceived importance of breast cancer education, and explored associations with demographic factors. Of 2089 schoolgirls (11-18 years) surveyed, 1958 completed all relevant breast cancer questions and demographic factors (ethnicity, school type, breast size, physical activity level and age)...
March 30, 2017: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28358737/delay-in-sexual-maturation-in-perinatally-hiv-infected-youths-is-mediated-by-poor-growth
#18
Andrea Bellavia, Paige L Williams, Linda A DiMeglio, Rohan Hazra, Mark J Abzug, Kunjal Patel, Denise L Jacobson, Russell B Van Dyke, Mitchell E Geffner
OBJECTIVE: To evaluate the association between HIV infection and sexual maturation, and mediation of this association by HIV effects on growth. DESIGN: Pooled data were analyzed from two longitudinal cohort studies, the International Maternal Pediatric Adolescent AIDS Clinical Trials P219/219C Study (1993-2007) and the Pediatric HIV/AIDS Cohort Study Adolescent Master Protocol (2007-2015), including perinatally HIV-infected (PHIV) and HIV-exposed uninfected (PHEU) youths...
June 1, 2017: AIDS
https://www.readbyqxmd.com/read/28347373/using-stable-isotope-techniques-in-nutrition-assessments-and-tracking-of-global-targets-post-2015
#19
Victor O Owino, Christine Slater, Cornelia U Loechl
Stable isotopes are non-radioactive, safe and are applied for various purposes in human health assessment in trace amounts that minimally disturb normal physiology. The International Atomic Energy Agency supports the use of stable isotope techniques to design and evaluate interventions addressing malnutrition in all its forms with focus on infant and young child feeding; maternal and adolescent nutrition; diet quality; prevention and control of non-communicable diseases; healthy ageing and gut function. These techniques can be used to objectively measure: (1) amount of human milk consumed and whether an infant is exclusively breastfed; (2) body composition in the context of re-feeding programmes for moderate and severe acute malnutrition and as an indicator of the risk for obesity; (3) bioavailability and bioconversion of pro-vitamin A and vitamin A body stores following vitamin A intervention programmes; (4) absorption and retention of iron, zinc and protein; (5) total energy expenditure for validation of physical activity measurement and dietary assessment tools and (6) diagnosis of Helicobacter pylori...
March 28, 2017: Proceedings of the Nutrition Society
https://www.readbyqxmd.com/read/28334337/birth-outcomes-among-adolescent-and-young-adult-cancer-survivors
#20
Chelsea Anderson, Stephanie M Engel, Jennifer E Mersereau, Kristin Z Black, William A Wood, Carey K Anders, Hazel B Nichols
Importance: Cancer diagnosis and treatment may adversely affect reproductive outcomes among female cancer survivors. Objective: To compare the birth outcomes of adolescent and young adult cancer survivors (AYA [diagnosed at ages 15-39 years]) with those of women without a cancer diagnosis. Design, Setting, and Participants: The North Carolina Central Cancer Registry (CCR) was used to identify female AYA cancer survivors diagnosed from January 2000 to December 2013; CCR records were linked to statewide birth certificate files from January 2000 to December 2014 to identify postdiagnosis live births to AYA survivors (n = 2598)...
March 23, 2017: JAMA Oncology
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