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https://www.readbyqxmd.com/read/27915987/sex-differences-in-alcohol-use-disorder
#1
Roberta Agabio, Claudia Pisanu, Gian Luigi Gessa, Flavia Franconi
BACKGROUND: Alcohol use disorder (AUD) is a common and disabling mental disorder associated with a significant burden of medical consequences and high socioeconomic costs. Although a growing number of studies support the existence of sex differences in several aspects of alcohol consumption and AUD, the majority of investigations have been conducted in men. OBJECTIVE: This article was aimed at reviewing sex differences in AUD, focusing on epidemiology, neurobiology, pharmacokinetics, susceptibility to medical consequences, and treatment...
December 1, 2016: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/27909901/obesity-and-breast-cancer
#2
Renée T Fortner, Verena Katzke, Tilman Kühn, Rudolf Kaaks
The relationship between adiposity and breast cancer risk and prognosis is complex, with associations that differ depending on when body size is assessed (e.g., pre- vs. postmenopausal obesity) and when breast cancer is diagnosed (i.e., pre- vs. postmenopausal disease). Further, the impact of obesity on risk differs by tumor hormone receptor status (e.g., estrogen (ER) and progesterone (PR) receptor) and, among postmenopausal women, use of exogenous hormones (i.e., hormone replacement therapy (HRT)). In the context of these complexities, this review focuses on associations between childhood and adolescent adiposity, general adiposity, weight changes (i...
2016: Recent Results in Cancer Research
https://www.readbyqxmd.com/read/27903360/-update-on-pubertal-development-among-primary-school-students-in-shanghai-2014
#3
Y Chen, Y T Zhang, C Chen, Y R Jiang, Y J Song, S J Liu, F Jiang
Objective: To investigate the current prevalence of pubertal development in healthy Shanghai schoolchildren. Methods: This study was a cross-sectional investigation focused on current pubertal development conducted in healthy Shanghai schoolchildren by multi-stage cluster sampling. The sample included 17 571 children in grades 1-5 investigated in June 2014. The data were weighted by inverse probability weighting (IPW) to make them more representative. At examination, stages of breast and pubic hair development were rated according to the Tanner method...
November 6, 2016: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/27879537/rhabdomyosarcoma-of-the-breast-in-adolescent-and-young-adult-aya-women
#4
Anthony N Audino, Bhuvana A Setty, Nicholas D Yeager
Soft tissue sarcoma constitutes 8% of all tumors in adolescent and young adults (AYA), with rhabdomyosarcoma (RMS) accounting for 5.2% to 6.5% of the soft tissue sarcoma total within this group. AYAs have a higher propensity for metastasis and inferior outcomes. Metastases to the breast have been reported in ∼3% to 6% of RMS cases. A review of our hospital's tumor registry identified cases of RMS diagnosed between January 1, 2004 and December 31, 2013. A total of 46 patients with RMS were identified, having a mean age of 12...
November 22, 2016: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/27869408/knowledge-level-attitude-and-own-experience-of-health-professionals-about-breastfeeding-and-breast-milk-in-a-city-of-turkey-cross-sectional-study
#5
Aylin Baydar Artantas, Burcu Kayhan Tetis, Melek Kılıc, İrep Karatas Eray, Nazan Cetin, Sinem Güney, Dogan Akdogan, Umut Domad, Yusuf Ustu, Mehmet Ugurlu
INTRODUCTION: Worldwide consensus about breastfeeding is that the infant should exclusively be breastfed until six months of life. Despite this, the rate of exclusive breastfeeding for the first six months of age is low in so many countries including Turkey. The aim of this study was to evaluate the knowledge, the attitudes and the own experiences of health professionals about breastfeeding and breast milk, in a metropolitan city in Turkey. MATERIALS AND METHODS: This study was performed between July 2012 and December 2013...
December 1, 2016: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/27846658/late-effects-following-treatment-of-hodgkin-lymphoma-during-childhood-and-adolescence-results-of-the-hodgkin-lymphoma-late-effects-research-project
#6
W Dörffel, M Riepenhausen, H Lüders, J Brämswig
Survival rates have been excellent in patients treated for Hodgkin lymphoma (HL) during childhood and adolescence. Unfortunately, severe treatment related late effects have been observed. It was therefore an important aim of the cooperative pediatric HL therapy studies in Germany to reduce the number of late effects without jeopardizing the excellent treatment results. Progress and relapses of HL were analyzed to obtain important information for the future salvage therapy. All late effects were documented and their etiologies analyzed...
November 2016: Klinische Pädiatrie
https://www.readbyqxmd.com/read/27845854/on-site-fertility-preservation-services-for-adolescents-and-young-adults-in-a-comprehensive-cancer-center
#7
Mary Peavey, Sara Arian, William Gibbons, Karen Lu, David Gershenson, Terri Woodard
PURPOSE: Adolescents and young adults (AYAs) receiving cancer treatments that may impair fertility should receive counseling about risk of infertility and options for fertility preservation (FP) before treatment and/or during survivorship. Our objective was to define the AYA patient population referred to an on-site fertility consultation service within a comprehensive cancer center and determine factors associated with patients proceeding with FP treatment. METHODS: We conducted a retrospective chart review of AYA women who completed a consultation at the MD Anderson Fertility Preservation and Family Building Service during the first year of service...
November 15, 2016: Journal of Adolescent and Young Adult Oncology
https://www.readbyqxmd.com/read/27832675/adolescent-contraception-before-and-after-pregnancy-choices-and-challenges-for-the-future
#8
Anderson Borovac-Pinheiro, Fernanda Garanhani Surita, Aline D'Annibale, Rodolfo de Carvalho Pacagnella, Joao Luiz Pinto E Silva
Objective To determine methods of contraception used by adolescents before and after pregnancy. Methods A cross-sectional study was performed, and data were collected from medical records of all teens in puerperal consultation at the Hospital da Mulher - José Aristodemo Pinotti (Caism), Universidade Estadual de Campinas (CAISM), São Paulo, Brazil, between July 2011 and September 2013. The inclusion criterion was being 10 to 19 years old, and the exclusion criterion was having a first consultation 90 days after childbirth...
November 10, 2016: Revista Brasileira de Ginecologia e Obstetrícia
https://www.readbyqxmd.com/read/27830423/trans-fatty-acids-in-colostrum-mature-milk-and-diet-of-lactating-adolescents
#9
Roseli de Souza Santos da Costa, Flavia da Silva Santos, Daniela de Barros Mucci, Tânia Vignuda de Souza, Fátima Lucia de Carvalho Sardinha, Célia Regina Moutinho de Miranda Chaves, Maria das Graças Tavares do Carmo
The purpose of this study was to investigate the trans fatty acids (TFA) content and distribution in colostrum, mature milk, and diet of adolescent mothers, after TFA declaration in food labels became mandatory in Brazil. Participants were healthy adolescents (n 54, 15-19 years, 1-90 days postpartum) practicing exclusive breastfeeding. Milk samples were collected 3 days after delivery (colostrum) and in the third month postpartum (mature milk) by hand expression. The fatty acid composition of the milk samples was determined by gas chromatography...
November 9, 2016: Lipids
https://www.readbyqxmd.com/read/27821991/a-study-to-assess-empowerment-of-adolescent-girls-in-terms-of-knowledge-based-life-skills-education-about-child-survival-and-safe-motherhood-practices
#10
A K Choudhary, D M Saxena, Rituja Kaushal
OBJECTIVE: This study has been designed with the intention to bring a substantial change in the mindsets or life skills of adolescent girls at secondary school level regarding their concept of child survival and safe motherhood practices in order to deal effectively with real-life situations. METHODOLOGY: A cross-sectional analytical study was carried out with 538 adolescent girls regarding assessment of their knowledge on variables like correct nutrition, iron-deficiency anemia and its prevention, care during pregnancy, safe birth, skilled birth attendance, breast feeding and complementary feeding practices, child's growth and development issues, immunization, management of common childhood illnesses...
December 2016: Journal of Obstetrics and Gynaecology of India
https://www.readbyqxmd.com/read/27821311/breastfeeding-and-motor-development-a-longitudinal-cohort-study
#11
Tegan Grace, Wendy Oddy, Max Bulsara, Beth Hands
BACKGROUND: While there is a large body of work supporting the importance of early feeding practices on cognitive, immunity, behavioural and mental outcomes, few longitudinal studies have focused on motor development. The relationship between duration of breast feeding and motor development outcomes at 10, 14, and 17years were examined. METHODS: Data were obtained from the Western Australian Pregnancy (Raine) Study. There were 2868 live births recorded and children were examined for motor proficiency at 10 (M=10...
November 4, 2016: Human Movement Science
https://www.readbyqxmd.com/read/27820124/breast-metastases-in-children-and-adolescents-with-rhabdomyosarcoma-a-large-single-institution-experience-and-literature-review
#12
Rejin Kebudi, Begum S Koc, Omer Gorgun, Alaaddin Celik, Abut Kebudi, Emin Darendeliler
INTRODUCTION: Breast metastasis is rare in childhood malignancies. Soft tissue sarcomas, especially rhabdomyosarcomas (RMS), and hematologic neoplasms, such as lymphomas, are the most common tumors that metastasize to the breast, albeit rare. MATERIALS AND METHODS: All cases with breast metastasis within a cohort of 200 RMS patients followed in our institution during 1990 to 2014 were assessed retrospectively and the literature was reviewed. RESULTS: There were 3 adolescent female patients with breast metastasis...
November 4, 2016: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/27810485/breast-cancer-risk-and-the-interaction-between-adolescent-body-size-and-weight-gain-in-later-life-a-case-control-study
#13
Ines Florath, Danja Sarink, Christobel Saunders, Jane Heyworth, Lin Fritschi
BACKGROUND: While the breast cancer risk associated with increasing adult BMI in postmenopausal women can be explained by increases in concentrations of endogenous estrogens the biologic mechanisms behind the inverse association between adolescent BMI and breast cancer risk are still a subject of controversial debate. METHODS: We investigated the association of breast cancer with body size and changes in body size across life time estimated by age-specific BMI Z scores and changes in BMI Z scores from teenage years to middle age in an age-matched population-based case-control study of 2994 Australian women...
December 2016: Cancer Epidemiology
https://www.readbyqxmd.com/read/27805927/management-of-gynecomastia-in-patients-with-different-body-types-considerations-on-312-consecutive-treated-cases
#14
Alessandro Innocenti, Dario Melita, Francesco Mori, Francesco Ciancio, Marco Innocenti
BACKGROUND: Gynecomastia is a common finding in male subjects which incidence varies widely in the world population. In adolescents, it is frequently temporary but, if it becomes persistent, it generates considerable embarrassment, inducing the patients to seek surgical consultation. Even in patients with good body contour, gynecomastia creates even greater distress considering the special attention given by these subjects to their physical appearance. The authors present their experience in the treatment of gynecomastia comparing different body types of patients with the aim to investigate dissimilar expectations, needs and surgical outcomes thus optimizing the management of the pathological condition, achieving high levels of agreement and reducing unsatisfied patients arising from cosmetic surgery...
November 1, 2016: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/27765796/early-life-residence-fish-consumption-and-risk-of-breast-cancer
#15
Alfheidur Haraldsdottir, Laufey Steingrimsdottir, Unnur Valdimarsdottir, Thor Aspelund, Laufey Tryggvadottir, Tamara B Harris, Lenore Launer, Lorelei A Mucci, Edward L Giovannucci, Hans-Olov Adami, Vilmundur Gudnason, Johanna E Torfadottir
BACKGROUND: Little is known about fish intake throughout the life course and the risk of breast cancer. METHODS: We used data on the first residence of 9,340 women born 1908-1935 in the Reykjavik Study as well as food frequency data for different periods of life from a subgroup of the cohort entering the AGES-Reykjavik Study (n = 2,882). RESULTS: During a mean follow-up of 27.3 years, 744 women were diagnosed with breast cancer in the Reykjavik Study...
October 10, 2016: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/27758851/multimodality-approach-in-the-diagnosis-and-management-of-bilateral-giant-juvenile-breast-fibroadenoma
#16
Noora Rafeek, Rajeswaran Rangasami, Kamakshi Dhanraj, Santhosh Joseph
Juvenile giant fibroadenoma is a very rare breast disease affecting young girls of premenarche and adolescent ages. It is a benign fibroepithelial tumour characterised by stromal and epithelial proliferation that causes rapidly growing breast mass. Bilateral symmetrical involvement is extremely rare. In this article, we describe this entity in a girl aged 13 years who presented with bilateral gigantically enlarged breasts. Ultrasonography and MRI showed large, multilobulated masses involving both breasts entirely...
October 6, 2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27738376/paroxetine-the-antidepressant-from-hell-probably-not-but-caution-required
#17
Robert M Nevels, Samuel T Gontkovsky, Bryman E Williams
Paroxetine, also known by the trade names Aropax, Paxil, Pexeva, Seroxat, Sereupin and Brisdelle, was first marketed in the U.S. in 1992. Effective for major depression and various anxiety disorders, it quickly gained a sizable share of the antidepressant prescription market. By the late 1990s, paroxetine frequently was being associated with serious drug interactions and medication side effects. Most significantly, in a major Canadian epidemiological study examining the relationship between antidepressants and diseases, paroxetine was associated with a 620 percent increase in the rate of breast cancer in women who had taken it over a four-year period...
March 1, 2016: Psychopharmacology Bulletin
https://www.readbyqxmd.com/read/27721839/effects-of-early-menarche-on-physical-and-psychosocial-health-problems-in-adolescent-girls-and-adult-women
#18
Jae-Ho Yoo
The menarcheal age of Korean women has been rapidly decreasing for the last 50 years, and the average menarcheal age of women born in the 1990s is approaching 12.6 years. In addition, interest in early puberty has been increasing recently owing to the rapid increase in precocious puberty. Generally, out of concern for short stature and early menarche, idiopathic central precocious puberty in female adolescents is treated with gonadotropin-releasing hormone analogs. Studies to date have described the association between early menarche and psychosocial problems such as delinquency and risky sexual behavior, as well as physical health problems such as obesity, diabetes, cardiovascular diseases, and breast cancer throughout the lifespan of women...
September 2016: Korean Journal of Pediatrics
https://www.readbyqxmd.com/read/27693095/clinical-practice-guidelines-for-vitamin-d-in-the-united-arab-emirates
#19
Afrozul Haq, Sunil J Wimalawansa, Pawel Pludowski, Fatme Al Anouti
In the UAE and the Gulf region in general, there are several intricate public health issues in the context of vitamin D deficiency that needs to be addressed. Changes in lifestyle such as diet, lack of exercise, cultural habits, avoiding sun exposure due to excessive heat, and other risk factors predispose those who live in GULF countries, such as Emiratis likely to becoming vitamin D deficient. Consequently, the prevalence of vitamin D deficiency is high, and new guidelines are needed to overcome this major public health issue...
September 28, 2016: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/27651058/-the-clonal-evolution-of-osteosarcomas
#20
D Baumhoer
Osteosarcomas are highly aggressive bone tumors that mainly occur in the metaphyses of long bones in children and adolescents. Genetically, they are characterized by complex structural and numerical aberrations with large intra- and interindividual variations which hamper the identification of the initiating and driving events. Sequencing and copy number analyses in a study of 123 pretherapeutic osteosarcoma samples identified mutations in 14 genes as the potential main drivers. Although almost half of all osteosarcomas could be attributed to mutations in TP53 and RB1, no single driver gene could be found that was clearly responsible for the majority of tumors...
November 2016: Der Pathologe
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