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https://www.readbyqxmd.com/read/29222035/carriage-of-esbl-producing-enterobacteriaceae-in-french-hospitals-the-portablse-study
#1
B Pilmis, V Cattoir, D Lecointe, A Limelette, I Grall, A Mizrahi, G Marcade, I Poilane, T Guillard, N Bourgeois Nicolaos, J-R Zahar, A Le Monnier
BACKGROUND: Currently, contact precautions are recommended for patients colonized or infected with extended spectrum beta-lactamase producing enterobacteriaceae (ESBL-PE). Recent studies have challenged this strategy. This study aimed to assess the rate of ESBL-PE faecal carriage among hospitalized patients according to type of hospital ward, and to identify risk factors associated with carriage. METHODS: We conducted a point prevalence study in five different types of hospital wards (medical, surgical, intensive care unit (ICU), after care and rehabilitation and geriatric) in 8 French hospitals...
December 5, 2017: Journal of Hospital Infection
https://www.readbyqxmd.com/read/29220754/association-of-high-mortality-with-extended-spectrum-%C3%AE-lactamase-esbl-positive-cultures-in-community-acquired-infections
#2
Sumit Ray, Dimple Anand, Sankalp Purwar, Arijit Samanta, Kaustubh V Upadhye, Prasoon Gupta, Debashis Dhar
PURPOSE: Infections due to multidrug resistant organisms have become a serious health concern worldwide. The present study was conducted to investigate the spectrum of microbial resistance pattern in the community and their effects on mortality. METHODS: A retrospective review and analysis of prospectively collected data was done of all patients admitted with diagnosis of sepsis in two tertiary care ICU's for a period of two years. Demographics, culture positivity, microbial spectrum, resistance pattern and outcome data were collected...
October 31, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/29216906/detection-of-metallo-%C3%AE-lactamases-encoding-genes-among-clinical-isolates-of-pseudomonas-aeruginosa-in-a-tertiary-care-hospital-kathmandu-nepal
#3
Mahesh Acharya, Prabhu R Joshi, Kamal Thapa, Rajan Aryal, Trishna Kakshapati, Supriya Sharma
OBJECTIVES: This study was carried out to determine the prevalence of metallo-β-lactamases (MBLs) producing Pseudomonas aeruginosa in imipenem-nonsusceptible isolates and to detect MBL-encoding genes among MBLs-positive isolates. RESULTS: Metallo-β-lactamases production was detected in 68.6% isolates of P. aeruginosa with reduced susceptibility to imipenem. The bla VIM-2 gene was detected in 75% isolates and bla IMP-1 was detected in 25% isolates. All MBLs-positive isolates were multidrug resistant with a high level of resistance to imipenem (MIC 16 to ≥ 32 µg/ml), meropenem (MIC 16 to ≥ 32 µg/ml), and ceftazidime (MIC 64 to ≥ 512 µg/ml)...
December 8, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/29216350/italian-nationwide-survey-on-pseudomonas-aeruginosa-from-invasive-infections-activity-of-ceftolozane-tazobactam-and-comparators-and-molecular-epidemiology-of-carbapenemase-producers
#4
Tommaso Giani, Fabio Arena, Simona Pollini, Vincenzo Di Pilato, Marco Maria D'Andrea, Lucia Henrici De Angelis, Matteo Bassetti, Gian Maria Rossolini
Objectives: Pseudomonas aeruginosa is a major cause of severe healthcare-associated infections and often shows MDR phenotypes. Ceftolozane/tazobactam is a new cephalosporin/β-lactamase inhibitor combination with potent activity against P. aeruginosa. This survey was carried out to evaluate the susceptibility of P. aeruginosa, circulating in Italy, to ceftolozane/tazobactam and comparators and to investigate the molecular epidemiology of carbapenemase-producing strains. Methods: Consecutive non-replicate P...
December 5, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29215863/near-infrared-laser-excited-nanoparticles-to-eradicate-multidrug-resistant-bacteria-and-promote-wound-healing
#5
Yue Qiao, Fei Ma, Chao Liu, Bo Zhou, Qiaolin Wei, Wanlin Li, Danni Zhong, Yangyang Li, Min Zhou
With the ever-growing threat of bacterial infections, especially for multidrug-resistant microbial infections, the development of highly effective treatment modalities to inhibit the infections is challenging. Although silver nanoparticles have been intensively applied as an antimicrobial agent for decades, the therapeutic efficacy towards multidrug-resistant bacteria is still unsatisfactory. Here, we show that near-infrared (NIR) laser-excited silver triangular nanoparticles (Tri-Ag) can efficiently kill Gram-negative Escherichia coli (E...
December 7, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29215330/quantifying-hospital-acquired-carriage-of-extended-spectrum-beta-lactamase-producing-enterobacteriaceae-among-patients-in-dutch-hospitals
#6
Marjolein F Q Kluytmans-van den Bergh, Suzan P van Mens, Manon R Haverkate, Martin C J Bootsma, Jan A J W Kluytmans, Marc J M Bonten
BACKGROUND Extended-spectrum β-lactamase-producing Enterobacteriaceae (ESBL-E) are emerging worldwide. Contact precautions are recommended for known ESBL-E carriers to control the spread of ESBL-E within hospitals. OBJECTIVE This study quantified the acquisition of ESBL-E rectal carriage among patients in Dutch hospitals, given the application of contact precautions. METHODS Data were used from 2 cluster-randomized studies on isolation strategies for ESBL-E: (1) the SoM study, performed in 14 Dutch hospitals from 2011 through 2014 and (2) the R-GNOSIS study, for which data were limited to those collected in a Dutch hospital in 2014...
December 7, 2017: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/29214986/antibiotic-resistance-in-enterobacter-cloacae-strains-with-derepressed-partly-derepressed-inducible-ampc-and-extendedspectrum-beta-lactamases-in-zenica-doboj-canton-bosnia-and-herzegovina
#7
Selma Uzunović, Amir Ibrahimagić, Branka Bedenić
Aim To investigate the prevalence of derepressed/partly derepressed/inducible and ESBL/AmpC-producing Enterobacter cloacae isolates and treatment options for infections associated with those isolates. Methods Antibiotic susceptibility was determined by disc diffusion and broth microdilution according to CLSI guidelines. Doubledisk synergy test (DDST) was performed in order to screen for ESBLs and combined disk test with phenylboronic acid to detect AmpC β -lactamases. PCR was used to detect blaESBL/blacarb genes...
February 1, 2018: Medicinski Glasnik
https://www.readbyqxmd.com/read/29214016/genotypic-characterization-of-gentamicin-and-cephalosporin-resistant-escherichia-coli-isolates-from-blood-cultures-in-a-norwegian-university-hospital-2011-2015
#8
Øyvind Andreas Fladberg, Silje Bakken Jørgensen, Hege Vangstein Aamot
Background: Cephalosporin resistance in clinical E. coli isolates is increasing internationally. The increase has been caused by virulent and often multidrug-resistant clones, especially the extended spectrum β-lactamase (ESBL) producing E. coli clone O25b-ST131. Methods: In Norway, recommended empirical treatment of sepsis consists of gentamicin and penicillin combined, or a broad-spectrum cephalosporin. To investigate if increased gentamicin and cephalosporins resistance rates in our hospital could be caused by specific clones, we conducted a retrospective study on E...
2017: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/29213998/phenotypic-and-genetic-characterization-of-%C3%AE-lactam-resistance-in-klebsiella-from-retail-chicken-meat-in-mansoura-egypt
#9
Hazem Ramadan, Amal Awad
Background and Objectives: This study was undertaken to characterize antimicrobial resistance phenotypes and genes encoding extended spectrum β-lactamases (ESBLs) in Klebsiella isolated from retail chicken meat in Mansoura, Egypt. Materials and Methods: Three hundred sixty chicken meat samples from 120 eviscerated chicken carcasses (3 cuts each) collected randomly from local retail chicken shops in Mansoura, Egypt during the period from April to June 2015, were assayed for the presence of Klebsiella by conventional bacteriological methods...
April 2017: Iranian Journal of Microbiology
https://www.readbyqxmd.com/read/29211984/promiscuous-protein-binding-as-a-function-of-protein-stability
#10
Ruth Cohen-Khait, Orly Dym, Shelly Hamer-Rogotner, Gideon Schreiber
Proteins have evolved to balance efficient binding of desired partners with rejection of unwanted interactions. To investigate the evolution of protein-protein interactions, we selected a random library of pre-stabilized TEM1 β-lactamase against wild-type TEM1 using yeast surface display. Three mutations were sufficient to achieve micromolar affinity binding between the two. The X-ray structure emphasized that the main contribution of the selected mutations was to modify the protein fold, specifically removing the N'-terminal helix, which consequently allowed protein coupling via a β-sheet-mediated interaction resembling amyloid interaction mode...
December 5, 2017: Structure
https://www.readbyqxmd.com/read/29209306/ctx-m-15-producing-e-coli-isolates-from-food-products-in-germany-are-mainly-associated-with-an-incf-type-plasmid-and-belong-to-two-predominant-clonal-e-coli-lineages
#11
Alexandra Irrgang, Linda Falgenhauer, Jennie Fischer, Hiren Ghosh, Elisabet Guiral, Beatriz Guerra, Silvia Schmoger, Can Imirzalioglu, Trinad Chakraborty, Jens A Hammerl, Annemarie Käsbohrer
Extended-spectrum beta-lactamases (ESBL) mediating resistance to 3rd generation cephalosporins are a major public health issue. As food may be a vehicle in the spread of ESLB-producing bacteria, a study on the occurrence of cephalosporin-resistantu Escherichia coli in food was initiated. A total of 404 ESBL-producing isolates were obtained from animal-derived food samples (e.g., poultry products, pork, beef and raw milk) between 2011 and 2013. As CTX-M-15 is the most abundant enzyme in ESBL-producing E. coli causing human infections, this study focusses on E...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29208868/detection-of-plasmid-mediated-ampc-%C3%AE-lactamases-among-gram-negative-uropathogens-at-a-tertiary-care-hospital-dhaka-city
#12
N Begum, S M Shamsuzzaman, S Afroz, A K Azad
Plasmid-mediated AmpC β-lactamase (PMABL) resistance among gram negative bacilli is an emerging problem worldwide. They likely originate from chromosomal AmpC of certain Gram-negative bacterial species and subsequently are mobilized to transmissible plasmids. There are reports of unfavorable clinical outcomes in patients infected with these organisms and treated with broad-spectrumcephalosporins. The present cross sectional study was designed to detect PMABL genes among gram negative uropathogens in a tertiary care hospital, Dhaka city, Bangladesh from January 2014 to December 2014...
October 2017: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/29207766/successful-management-of-urosepsis-with-ceftriaxone-sulbactam-edta-a-case-report-of-penem-sparing-approach
#13
Amit Bery, Candy Sodhi, Rishu Bhanot
Over the past decade, the Anti-Microbial Resistance (AMR) among members of Enterobacteriaceae family is on rise mainly due to rapid spread of strains producing Extended-Spectrum Beta-Lactamases (ESBLs) and Metallo Beta-Lactamases (MBLs). Hence, the choice of drugs available for these resistant strains is diminishing and their treatment is becoming more challenging. This is a case of complicated Urinary Tract Infection (cUTI) due to ESBL producing E. coli leading to septic shock which was successfully managed with Antibiotic Adjuvant Entity (AAE), a combination of ceftriaxone+sulbactam+EDTA...
September 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/29207706/detection-of-blactx-m-extended-spectrum-beta-lactamase-producing-salmonella-enterica-serotype-typhi-in-a-tertiary-care-centre
#14
Aishwarya Ramachandran, Mariappan Shanthi, Uma Sekar
Introduction: Infections caused by Salmonella are an important public health threat in tropical and subtropical countries. Due to the emergence of resistance to ampicillin, chloramphenicol and trimethoprim/sulfamethoxazole (multidrug resistant salmonellae) in the late 1980s, fluoroquinolones and extended spectrum cephalosporins became the drugs of choice. Resistance to cefotaxime and ceftriaxone due to the production of Extended Spectrum Beta-Lactamase (ESBL) and reduced susceptibility to ciprofloxacin have emerged resulting in treatment failure...
September 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/29206750/ceftazidime-avibactam-antimicrobial-activity-and-spectrum-when-tested-against-gram-negative-organisms-from-pediatric-patients-results-from-the-inform-surveillance-program-united-states-2011-2015
#15
Helio S Sader, Michael D Huband, Leonard R Duncan, Robert K Flamm
BACKGROUND: Ceftazidime-avibactam was approved by the US Food and Drug Administration in 2015 to treat complicated intra-abdominal and urinary tract infections in adults, and is under clinical development for treating pediatric patients. METHODS: Among 53,381 gram-negative organisms (1 per patient) collected in 2011-2015, 8,461 (15.9%) were from pediatric (≤17 years-old [yo]) patients. The isolates were collected from 82 US medical centers and susceptibility tested against ceftazidime-avibactam (avibactam at fixed 4 µg/mL) and comparators by reference broth microdilution methods...
December 4, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29205195/coexistence-of-metallo-beta-lactamase-encoding-genes-in-pseudomonas-aeruginosa
#16
Lavanya Mohanam, Thangam Menon
BACKGROUND & OBJECTIVES: The emergence and rapid spread of carbapenem resistance mediated by metallo-beta-lactamase (MBL) in Pseudomonas aeruginosa is of major concern due to limited therapeutic options. This study was aimed at detecting the presence of MBL and its association with integrons in imipenem-resistant P. aeruginosa isolates and to determine their genetic relatedness. METHODS: A total of 213 P. aeruginosa isolates were collected from two tertiary care centres and tested against anti-pseudomonal antibiotics by antimicrobial susceptibility testing, followed by the detection of MBL production by combined disk method...
July 2017: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/29205194/analysis-of-beta-lactamases-blandm-1phylogeny-plasmid-replicons-in-multidrug-resistant-klebsiella-spp-from-a-tertiary-care-centre-in-south-india
#17
N Nithya, Rabindran Remitha, P R Jayasree, M Faisal, P R Manish Kumar
BACKGROUND & OBJECTIVES: β-lactamases play a predominant role in drug-resistance amongst Enterobacteriaceae. Presence of genes on transferable plasmids encoding these enzymes favours their dissemination across species and genera within and outside geographical boundaries. This study was aimed to understand the presence of β-lactamases and transferable plasmids in clinical isolates of Klebsiella spp. which can contribute to the spread of resistance determinants. METHODS: A total of 41 clinical isolates of Klebsiella spp...
July 2017: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/29205192/genetic-diversity-study-of-various-%C3%AE-lactamase-producing-multidrug-resistant-escherichia-coli-isolates-from-a-tertiary-care-hospital-using-eric-pcr
#18
Jayanti Jena, Nagen Kumar Debata, Rajesh Kumar Sahoo, Mahendra Gaur, Enketeswara Subudhi
BACKGROUND & OBJECTIVES: The prevalence of multidrug-resistant (MDR) Escherichia coli isolates producing β-lactamase enzyme is a growing problem across the globe. Strain typing is an epidemiologically important tool not only for detecting the cross transmission of nosocomial pathogens but also for determining the source of infection. The present study was conducted to understand the clonal relationship among various β-lactamase-producing MDR E. coli isolates using enterobacterial repetitive intergenic consensus (ERIC) polymerase chain reaction (PCR)...
July 2017: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/29205165/prevalence-of-antibiotic-resistance-in-fecal-flora-before-transrectal-ultrasound-guided-prostate-biopsy-and-the-clinical-impact-of-targeted-antibiotic-prophylaxis
#19
Arikan Ozgur, Yildirim Asif, Atis Gokhan, Tanidir Berrin, Gurbuz Cenk, Erol Bulent, Danacioglu Onur, Culpan Meftun, Vahapoglu Haluk, Caskurlu Hulya, Caskurlu Turhan
OBJECTIVES: In this study, we aimed to evaluate ciprofloxacin resistance and the presence of extended-spectrum beta-lactamase producing organisms (ESBLs) in the population of patients with indication to undergo prostate biopsy. Our additional aim was to compare the targeted antibiotic prophylaxis and sepsis rates after transrectal ultrasound guided prostate biopsy in patients who received routine ciprofloxacin prophylaxis and to evaluate the predictive factors of antibiotic resistance...
December 2017: Archivos Españoles de Urología
https://www.readbyqxmd.com/read/29204282/in%C3%A2-vivo-selection-of-a-multidrug-resistant-aeromonas-salmonicida-during-medicinal-leech-therapy
#20
E Ruppé, A Cherkaoui, N Wagner, G C La Scala, J-Y Beaulieu, M Girard, J Frey, V Lazarevic, J Schrenzel
We report the selection in a 15-year-old boy of a multidrug-resistant, extended-spectrum β-lactamase (ESBL)-producing Aeromonas salmonicida after medicinal leech therapy that required an antibiotic prophylaxis based on piperacillin/tazobactam and cotrimoxazole. Whole genome sequencing of the strain indeed revealed 13 antibiotic resistance genes, including the ESBL CTX-M-3 and the unusual β-lactamase SCO-1.
January 2018: New Microbes and New Infections
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