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Urothelial cell carcinoma

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https://www.readbyqxmd.com/read/28327194/upregulation-of-the-long-noncoding-rna-uca1-affects-the-proliferation-invasion-and-survival-of-hypopharyngeal-carcinoma
#1
Ye Qian, Dayu Liu, Shengda Cao, Ye Tao, Dongmin Wei, Wenming Li, Guojun Li, Xinliang Pan, Dapeng Lei
BACKGROUND: Several long noncoding RNAs (lncRNAs) are involved in oncogenesis. METHODS AND RESULTS: Our microarray analysis showed that numerous lncRNAs are dysregulated in hypopharyngeal squamous cell carcinoma (HSCC) tumor tissues as compared with normal tissues. Among those lncRNAs, urothelial carcinoma-associated 1 (UCA1) has been found to have an oncogenic role in HSCC. We confirmed the upregulation of UCA1 in HSCC by assessing its expression levels in a cohort of 53 patient tumors and paired non-tumor samples...
March 21, 2017: Molecular Cancer
https://www.readbyqxmd.com/read/28323779/gata3-and-myb-expression-in-cutaneous-adnexal-neoplasms
#2
Joana Pardal, Uma Sundram, M Angelica Selim, Mai P Hoang
Knowledge of staining pattern of certain immunostains might be useful in the classification of cutaneous adnexal tumors that can have clinical importance. We studied GATA3 and MYB expression in archival materials of 220 adnexal tumors comprised of sebaceous carcinomas, follicular tumors, apocrine carcinoma, predominantly apocrine tumors, predominantly eccrine tumors, and others including adenoid cystic carcinomas. Nuclear GATA3 expression was seen in 70% (153/220) of cases, including sebaceous carcinoma (93%), apocrine carcinoma (93%), follicular neoplasms (100%), and predominantly apocrine neoplasms (69%), yet only 38% of predominantly eccrine neoplasms...
April 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28316088/gata3-expression-in-benign-prostate-glands-with-radiation-atypia-a-diagnostic-pitfall
#3
Wei Tian, David Dorn, Shi Wei, Ronald D Sanders, Andres Matoso, Rajal B Shah, Jennifer Gordetsky
OBJECTIVE: Patients who have undergone prostate radiation are at an increased risk for developing urothelial carcinoma. Radiation changes can cause significant cytologic atypia in benign prostate glands that may mimic pagetoid spread of urothelial carcinoma. GATA3 is a common marker to differentiate prostatic adenocarcinoma from urothelial carcinoma. We investigated the expression of GATA3 in the epithelium of irradiated benign and malignant prostate tissue. METHODS: We performed a retrospective review of prostate cases with radiation atypia...
March 17, 2017: Histopathology
https://www.readbyqxmd.com/read/28315290/uca1-regulates-the-growth-and-metastasis-of-pancreatic-cancer-by-sponging-mir-135a
#4
Xiaobo Zhang, Feng Gao, Lei Zhou, Huaitao Wang, Gang Shi, Xiaodong Tan
Pancreatic cancer (PC) is a devastating malignant disease with poor prognosis. This study is aimed to investigate the role of urothelial carcinoma associated 1(UCA1) in the progression of PC. Our results revealed that long non-coding RNAs (lncRNAs)-UCA1 was overexpressed in PC tissues compared with adjacent histologically normal tissues. Down-regulated level of UCA1 was also detected in five human pancreatic cancer cell lines (SW1990,BxPC-3, MiaPaCa-2, PANC-1, CAPAN-1) compared with normal pancreatic duct epithelial HPDE cells...
March 7, 2017: Oncology Research
https://www.readbyqxmd.com/read/28314306/expression-of-indoleamine-2-3-dioxygenase-gene-is-a-feature-of-poorly-differentiated-non-muscle-invasive-urothelial-cell-bladder-carcinomas
#5
Tvrtko Hudolin, Chantal Mengus, Julie Coulot, Zeljko Kastelan, Ahmad El-Saleh, Giulio C Spagnoli
AIM: To evaluate indoleamine 2,3-dioxygenase (IDO) gene expression in non-muscle-invasive urothelial cell bladder carcinoma (NMIBC). PATIENTS AND METHODS: Seventy-four patients undergoing surgical treatment for NMIBC were enrolled in the study. IDO gene expression was assessed by quantitative real-time polymerase chain reaction (qRT-PCR). RESULTS: IDO gene expression was detectable significantly more frequently (48/74, 64.86% vs. 5/21, 23...
March 2017: Anticancer Research
https://www.readbyqxmd.com/read/28314276/evodiamine-induces-cell-growth-arrest-apoptosis-and-suppresses-tumorigenesis-in-human-urothelial-cell-carcinoma-cells
#6
Chung-Sheng Shi, Jhy-Ming Li, Chih-Chien Chin, Yi-Hung Kuo, Ying-Ray Lee, Yun-Ching Huang
BACKGROUND/AIM: Evodiamine, an indole alkaloid derived from Evodia rutaecarpa, exhibits pharmacological activities including vasodilatation, analgesia, anti-cardiovascular disease, anti-Alzheimer's disease, anti-inflammation, and anti-tumor activity. MATERIALS AND METHODS: This study analyzes the anti-tumor effects of evodiamine on cellular growth, tumorigenesis, cell cycle and apoptosis induction of human urothelial cell carcinoma (UCC) cells. RESULTS: The present study showed that evodiamine significantly inhibited the proliferation of UCC cells in a dose- and time-dependent manner...
March 2017: Anticancer Research
https://www.readbyqxmd.com/read/28306559/immunotherapy-a-new-treatment-paradigm-in-bladder-cancer
#7
Nicole N Davarpanah, Akira Yuno, Jane B Trepel, Andrea B Apolo
PURPOSE OF REVIEW: T-cell checkpoint blockade has become a dynamic immunotherapy for bladder cancer. In 2016, atezolizumab, an immune checkpoint inhibitor, became the first new drug approved in metastatic urothelial carcinoma (mUC) in over 30 years. In 2017, nivolumab was also approved for the same indication. This overview of checkpoint inhibitors in clinical trials focuses on novel immunotherapy combinations, predictive biomarkers including mutational load and neoantigen identification, and an evaluation of the future of bladder cancer immunotherapy...
March 16, 2017: Current Opinion in Oncology
https://www.readbyqxmd.com/read/28291636/correlation-between-messenger-rna-expression-and-protein-expression-of-immune-checkpoint-associated-molecules-in-bladder-urothelial-carcinoma-a-retrospective-study
#8
Constance Le Goux, Diane Damotte, Sophie Vacher, Mathilde Sibony, Nicolas Barry Delongchamps, Anne Schnitzler, Benoit Terris, Marc Zerbib, Ivan Bieche, Géraldine Pignot
OBJECTIVES: Immunotherapy for bladder cancer seems to have promising results. Here, we evaluated the association between messenger RNA (mRNA) and protein levels and possible prognostic value of the programmed cell death 1/programmed cell death ligand 1 (PD-1/PD-L1) and cytotoxic T-lymphocyte-associated protein 4 (CTLA4) immune checkpoint pathways during bladder carcinogenesis. METHODS AND MATERIALS: Tumor samples were obtained from 155 patients (84 with muscle-invasive bladder cancer [MIBC], and 71 non-muscle-invasive bladder cancer [NMIBC]) and normal bladder tissue from 15 patients...
March 10, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28290211/influence-of-hematuria-and-infection-on-diagnostic-accuracy-of-urinary-lasp1-a-new-biomarker-for-bladder-carcinoma
#9
Elke Butt, Jan Ebbing, Lukas Bubendorf, Peter Ardelt
AIM: To further promote the clinical use of urinary LASP1 as biomarker for urothelial carcinoma of the bladder regarding limitations and alternative testing systems. PATIENTS & METHODS: Urine stabilization, alternative measurement systems and limitations by erythrocyte contamination and infection were investigated in 246 patients. RESULTS: Thimerosal allowed sufficient stabilization. Fluorescence-activated cell sorting analysis was not influenced by presence of erythrocytes or leukocytes and reliably urothelial carcinoma of the bladder but cell counts in specimen were low...
March 14, 2017: Biomarkers in Medicine
https://www.readbyqxmd.com/read/28280687/clear-cell-adenocarcinoma-of-the-female-urethra-mimicking-cystocele
#10
Yassine Ayari, Walid Kerkeni, Nadia Znaidi, A Blel, A Bouzouita, H Ayed, Mohamed Cherif, Mohamed Riadh Ben Slama, Amine Derouiche, Soumaya Rammeh, Mohamed Chebil
Clear cell adenocarcinoma of the urethra is an extremely rare neoplasm mainly described in women. Anterior pelvic exenteration was the treatment performed in most reported cases. It seems to have poorer prognosis than urothelial carcinomas.
May 2017: Urology Case Reports
https://www.readbyqxmd.com/read/28277277/immunoregulation-of-dendritic-cell-subsets-by-inhibitory-receptors-in-urothelial-cancer
#11
Mathieu F Chevalier, Perrine Bohner, Claire Pieraerts, Benoit Lhermitte, Jolanta Gourmaud, Antoine Nobile, Samuel Rotman, Valerie Cesson, Virginie Martin, Anne-Sophie Legris, Florence Dartiguenave, Dalila Gharbi, Laurence De Leval, Daniel E Speiser, Denise Nardelli-Haefliger, Patrice Jichlinski, Laurent Derré
Blockade of inhibitory receptors (IRs) overexpressed by T cells can activate antitumor immune responses, resulting in the most promising therapeutic approaches, particularly in bladder cancer, currently able to extend patient survival. Thanks to their ability to cross-present antigens to T cells, dendritic cells (DCs) are an immune cell population that plays a central role in the generation of effective antitumor T-cell responses. While IR function and expression have been investigated in T cells, very few data are available for DCs...
October 27, 2016: European Urology
https://www.readbyqxmd.com/read/28272842/improved-risk-stratification-for-patients-with-high-grade-urothelial-carcinoma-following-application-of-the-paris-system-for-reporting-urinary-cytology
#12
Morgan L Cowan, Dorothy L Rosenthal, Christopher J VandenBussche
BACKGROUND: The Paris System for Reporting Urinary Cytology (TPS) requires 4 cytomorphologic criteria for a definitive diagnosis of high-grade urothelial carcinoma (HGUC) in urinary tract cytology (UTC) specimens: an elevated nuclear-to-cytoplasmic (N/C) ratio (at or above 0.7), markedly atypical nuclear borders, moderate to severe hyperchromasia, and coarse chromatin. However, malignant UTC specimens often contain degenerative changes, and this limits the number of malignant cells meeting all 4 TPS cytomorphologic criteria...
March 8, 2017: Cancer
https://www.readbyqxmd.com/read/28271214/long-non-coding-rna-uca1-regulates-the-expression-of-snail2-by-mir-203-to-promote-hepatocellular-carcinoma-progression
#13
Ji-Nan Xiao, Ting-Hua Yan, Rui-Ming Yu, Yi Gao, Wen-Long Zeng, Sui-Wan Lu, Hua-Xing Que, Ze-Ping Liu, Jin-Hua Jiang
PURPOSE: Long non-coding RNA (LncRNA) urothelial carcinoma-associated 1 (UCA1) is reported to be dysregulated in hepatocellular carcinoma (HCC) progression. However, the functions of UCA1 in HCC still need further study. The aim is to detect the role of UCA1 involving in HCC cells proliferation and invasion, and epithelial-mesenchymal transition (EMT). METHODS: The quantitative real-time PCR was used to detect the UCA1 and miR-203 expression levels in 60 cases' HCC tissues and adjacent normal tissues...
March 8, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28260171/renal-tumors-with-low-signal-intensities-on-t2-weighted-mr-image-radiologic-pathologic-correlation
#14
REVIEW
Youyeon Kim, Deuk Jae Sung, Ki Choon Sim, Na Yeon Han, Beom Jin Park, Min Ju Kim, Sung Bum Cho
Accurate characterization of renal masses is essential for ensuring appropriate management. Low T2 signal intensity is a common feature of papillary renal cell carcinoma and fat-poor angiomyolipoma. Nonetheless, other types of renal cell carcinoma, oncocytoma, hemangioma, lymphoma, leiomyoma, and urothelial cell carcinoma also can show low signal intensities on T2-weighted imaging (T2WI). Histopathologic features that can lead to low T2 signal intensities in renal tumors include smooth muscle component, papillary architecture, a high nucleus-to-cytoplasm ratio, and hemorrhage...
March 4, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28255490/plasmacytoid-urothelial-carcinoma-of-the-urinary-bladder-metastatic-to-the-duodenum-a-case-report-diagnostic-relevance-of-gata3-immunohistochemistry
#15
Hermann Brustmann
Plasmacytoid urothelial carcinoma (PUC) of the urinary bladder is a rare and aggressive subtype of urothelial carcinoma. Its deceptive morphology is characterized by a discohesive growth of cells with plasmacytoid morphology. Since this tumor might be confused with plasmacytoma, lymphoma, or carcinoma variants, appropriate diagnosis in small biopsy samples could be challenging. This study reports the case of a 53-year-old man who presented with frequent nocturnal urgency, without hematuria. A transurethral bladder and a prostate resection specimen displayed infiltration of neoplastic cells in a spray-like discohesive pattern with occasional formation of small irregular nests and cord-like arrangements...
2017: Case Reports in Pathology
https://www.readbyqxmd.com/read/28255027/akt-activation-mediates-acquired-resistance-to-fibroblast-growth-factor-receptor-inhibitor-bgj398
#16
Jharna Datta, Senthilkumar Damodaran, Hannah Parks, Cristina Ocrainiciuc, Jharna Miya, Lianbo Yu, Elijah P Gardner, Eric Samorodnitsky, Michele R Wing, Darshna Bhatt, John Hays, Julie W Reeser, Sameek Roychowdhury
Activation of FGFR signaling through mutations, amplifications, or fusions involving FGFR1, 2, 3, or 4 is seen in multiple tumors, including lung, bladder, and cholangiocarcinoma. Currently, several clinical trials are evaluating the role of novel FGFR inhibitors in solid tumors. As we move forward with FGFR inhibitors clinically, we anticipate the emergence of resistance with treatment. Consequently, we sought to study the mechanism(s) of acquired resistance to FGFR inhibitors using annotated cancer cell lines...
March 2, 2017: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/28251485/endoscopic-treatment-of-upper-tract-urothelial-carcinoma
#17
REVIEW
Daniel P Verges, Costas D Lallas, Scott G Hubosky, Demetrius H Bagley
PURPOSE OF REVIEW: This study aims to make the reader be aware of recent trends regarding the endoscopic management of upper tract urothelial carcinoma (UTUC) via review of the urologic literature over the past 5 years. Given the rare incidence of this disease, and the lack of level 1 evidence, systematic reviews and meta-analyses were also evaluated. Studies of importance are also considered and outlined in the annotated reference section. RECENT FINDINGS: The PubMed database was queried using the following medical subject headings (MeSH terms): "carcinoma, transitional cell," "ureter," "ureteral neoplasms," "kidney pelvis," "endoscopy," "laser therapy," "ureteroscopy," "urologic surgical procedures," and "ureteroscopes...
April 2017: Current Urology Reports
https://www.readbyqxmd.com/read/28247639/-renal-tumor-and-urolithiasis-is-there-a-relationship
#18
Yu G Alyaev, A M Pshikhachev, E V Shpot, G N Akopyan, A V Proskura
There is conflicting evidence on the impact of urolithiasis on the risk of developing cancer of kidney and upper urinary tract. Most researchers are of the opinion that there is a definite association between the diseases and clinicians should take the necessary measures to detect possible malignancy of the kidney and upper urinary tract in patients with urolithiasis at the earliest stages. However, the pathophysiological mechanisms that may underlie the development of renal cell carcinoma and urothelial cancer in patients with urolithiasis remain unexplored...
August 2016: Urologii︠a︡
https://www.readbyqxmd.com/read/28246759/-adverse-events-of-immune-checkpoint-inhibitors
#19
S Foller, H Oppel-Heuchel, I Fetter, Y Winkler, M-O Grimm
After immune checkpoint inhibitor therapy was approved for renal cell carcinoma last year, this new immune therapy has spread to urology. Further approvals (atezolizumab, nivolumab, pembrolizumab) are expected in 2017 for metastatic urothelial carcinoma that has progressed following treatment with platinum-based chemotherapy. With expanding use of immune checkpoint inhibitors, experience in diagnosing and managing immune-mediated adverse events increases. Although of low incidence, grade 3/4 toxicities play a central role...
February 28, 2017: Der Urologe. Ausg. A
https://www.readbyqxmd.com/read/28238417/enhanced-expression-of-programmed-cell-death-1-pd-1-protein-in-benign-vascular-anomalies
#20
Clarissa N Amaya, Frank H Wians, Brad A Bryan, Alireza Torabi
Programmed cell death 1 (PD-1) and its ligands have been shown to play a significant role in evasion of malignant tumour cells from the immune system. Last year, the United States Food and Drug Administration (FDA) approved anti-PD-1 inhibitors for treatment of non-small cell lung carcinoma and recently has approved anti-PD-L1 blocker for treatment of metastatic urothelial cell carcinoma. However, the role that the immune system might have on benign tumours including vascular anomalies has received less attention...
February 23, 2017: Pathology
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