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https://www.readbyqxmd.com/read/29131652/novel-homozygous-lrp5-mutations-in-mexican-patients-with-osteoporosis-pseudoglioma-syndrome
#1
Mirena C Astiazarán, María Cervantes-Sodi, Erick Rebolledo-Enríquez, Oscar Chacón-Camacho, Vanessa Villegas, Juan Carlos Zenteno
AIMS: Osteoporosis-pseudoglioma syndrome (OPPG) is an uncommon autosomal recessive disorder characterized by the rare association of early-onset osteoporosis and severe ocular abnormalities such as persistent fetal vasculature and microphthalmia. Biallelic mutations in the low-density lipoprotein receptor-related protein-5 gene (LRP5) have been associated with OPPG. We present clinical and genetic data of three Mexican OPPG patients, a pair of sibs, and a sporadic case. MATERIALS AND METHODS: Three patients underwent clinical examination, including a complete ophthalmic evaluation...
November 13, 2017: Genetic Testing and Molecular Biomarkers
https://www.readbyqxmd.com/read/29077194/metformin-for-endometrial-hyperplasia
#2
REVIEW
Naomi S Clement, Thomas Rw Oliver, Hunain Shiwani, Juliane Rf Sanner, Caroline A Mulvaney, William Atiomo
BACKGROUND: Endometrial cancer is one of the most common gynaecological cancers in the world. Rates of endometrial cancer are rising, in part because of rising obesity rates. Endometrial hyperplasia is a precancerous condition in women that can lead to endometrial cancer if left untreated. Endometrial hyperplasia occurs more commonly than endometrial cancer. Progesterone tablets currently used to treat women with endometrial hyperplasia are associated with adverse effects in up to 84% of women...
October 27, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29055780/pregnancy-outcomes-associated-with-extended-use-of-the-52-mg-20%C3%AE-g-day-levonorgestrel-releasing-intrauterine-system-beyond-60months-a-chart-review-of-776-women-in-brazil
#3
Luis Bahamondes, Arlete Fernandes, M Valeria Bahamondes, Cassia T Juliato, Moazzam Ali, Ilza Monteiro
OBJECTIVE: To assess the contraceptive performance of the 52-mg 20 μg/day levonorgestrel-releasing intrauterine system (LNG-IUS, Mirena, Bayer Oy, Turku, Finland) among women who maintain the same device without changes after 60months. STUDY DESIGN: This is a chart review study in which we assessed the charts of 766 women who continue the same LNG-IUS for contraception beyond 60months. The women were evaluated at the Family Planning clinic, University of Campinas Medical School, Campinas, SP, Brazil from November 1990 to March 2011...
October 18, 2017: Contraception
https://www.readbyqxmd.com/read/28861212/revised-disproportionality-analysis-of-mirena-and-benign-intracranial-hypertension
#4
Mahyar Etminan
No abstract text is available yet for this article.
September 2017: Therapeutic Advances in Drug Safety
https://www.readbyqxmd.com/read/28698465/progestin-intrauterine-devices-and-metformin-endometrial-hyperplasia-and-early-stage-endometrial-cancer-medical-management
#5
Oroma Nwanodi
Globally, endometrial cancer is the sixth leading cause of female cancer-related deaths. Non-atypical endometrial hyperplasia (EH), has a lifetime progression rate to endometrial cancer ranging from less than 5%, if simple without atypia, to 40%, if complex with atypia. Site specific, long-acting intrauterine devices (IUDs) provide fertility sparing, progestin-based EH medical management. It is unclear which IUD is most beneficial, or if progesterone sensitizing metformin offers improved outcomes. For resolution, PubMed searches for "Mirena" or "Metformin," "treatment," "endometrial hyperplasia," or "stage 1 endometrial cancer," were performed, yielding 33 articles...
July 8, 2017: Healthcare (Basel, Switzerland)
https://www.readbyqxmd.com/read/28675069/clarification-of-the-role-of-the-jaydess-skyla-lng-ius-13-5mg-and-kyleena-lng-ius-19-5mg-as-intrauterine-contraceptive-systems
#6
Norman D Goldstuck
Jaydess/Skyla and Kyleena are 'low dose' levonorgestrel releasing intrauterine systems(LNG-IUS). They differ from Mirena and other similar LNG-IUSs in terms of pharmacological properties and physical dimensions. There are currently no defined guidelines to decide when to use Jaydess or Kyleena or Mirena. Areas covered: MEDLINE, POPLINE, PubMed and clinicaltrials.gov were searched using the terms 'Jaydess', 'Skyla', LNG-IUS 13.5mg and 'Kyleena' LNG-IUS 19.5mg. Only clinical research articles as opposed to generalised reviews and opinion papers on the newer LNG-IUSs were considered for review...
August 2017: Expert Review of Medical Devices
https://www.readbyqxmd.com/read/28644236/cyp1b1-cytopathy-uncommon-phenotype-of-a-homozygous-cyp1b1-deletion-as-internal-corneal-ulcer-of-von-hippel
#7
Valeria Oliva-Biénzobas, Alejandro Navas, Mirena C Astiazarán, Oscar Francisco Chacón-Camacho, Jose A Bermúdez-Magner, Mariana Takane, Enrique Graue-Hernández, Juan Carlos Zenteno
PURPOSE: To report a mutation of CYP1B1 in a newborn with a rare phenotype without the classic features of anterior segment dysgenesis or congenital glaucoma. METHODS: The newborn presented with diffuse corneal edema and bilaterally elevated intraocular pressure (IOP). Ophthalmological examination, ultrasound, and ultrasound biomicroscopy were performed; congenital infections were ruled out. Genetic analysis was performed. The patient underwent penetrating keratoplasty and goniotomy in a single surgical time...
October 2017: Cornea
https://www.readbyqxmd.com/read/28562472/gonadotropin-releasing-hormone-agonist-combined-with-a-levonorgestrel-releasing-intrauterine-system-or-letrozole-for-fertility-preserving-treatment-of-endometrial-carcinoma-and-complex-atypical-hyperplasia-in-young-women
#8
Huimei Zhou, Dongyan Cao, Jiaxin Yang, Keng Shen, Jinghe Lang
OBJECTIVES: The aim of this study was to evaluate the efficacy and safety with gonadotropin-releasing hormone agonist (GnRHa) combined with a levonorgestrel-releasing intrauterine system or an aromatase inhibitor (letrozole) in young women with well-differentiated early endometrial carcinoma (EC) and complex atypical hyperplasia (CAH). METHODS: We performed a retrospective analysis including the clinical characteristics of 29 patients younger than 45 years with early well-differentiated endometrioid adenocarcinoma of the uterus (EC) or CAH who were treated at the Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, from January 2012 to April 2016...
July 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28488383/pax6-allelic-heterogeneity-in-mexican-congenital-aniridia-patients-expanding-the-mutational-spectrum-with-seven-novel-pathogenic-variants
#9
Sofía Pérez-Solórzano, Oscar F Chacón-Camacho, Mirena C Astiazarán, Gerardo Ledesma-Gil, Juan Carlos Zenteno
IMPORTANCE: The importance of the study was to describe the clinical characteristics and mutational analysis of Mexican patients with aniridia. BACKGROUND: Aniridia is a panocular hereditary eye disease caused by mutations in the PAX6 transcription factor. Mutation detection rate is highly variable ranging from 30% to 90% in different populations. Very few studies have been published about the PAX6 mutational analysis in aniridia patients from Mexico. In order to establish a more representative PAX6 mutational frequency in the country, a cohort of 22 Mexican unrelated aniridia probands were analysed in this study...
May 9, 2017: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/28369296/the-not-so-good-prognosis-of-streptococcal-periprosthetic-joint-infection-managed-by-implant-retention-the-results-of-a-large-multicenter-study
#10
Jaime Lora-Tamayo, Éric Senneville, Alba Ribera, Louis Bernard, Michel Dupon, Valérie Zeller, Ho Kwong Li, Cédric Arvieux, Martin Clauss, Ilker Uçkay, Dace Vigante, Tristan Ferry, José Antonio Iribarren, Trisha N Peel, Parham Sendi, Nina Gorišek Miksic, Dolors Rodríguez-Pardo, María Dolores Del Toro, Marta Fernández-Sampedro, Ulrike Dapunt, Kaisa Huotari, Joshua S Davis, Julián Palomino, Danielle Neut, Benjamin M Clark, Thomas Gottlieb, Rihard Trebše, Alex Soriano, Alberto Bahamonde, Laura Guío, Alicia Rico, Mauro J C Salles, M José G Pais, Natividad Benito, Melchor Riera, Lucía Gómez, Craig A Aboltins, Jaime Esteban, Juan Pablo Horcajada, Karina O'Connell, Matteo Ferrari, Gábor Skaliczki, Rafael San Juan, Javier Cobo, Mar Sánchez-Somolinos, Antonio Ramos, Efthymia Giannitsioti, Alfredo Jover-Sáenz, Josu Mirena Baraia-Etxaburu, José María Barbero, Peter F M Choong, Nathalie Asseray, Séverine Ansart, Gwenäel Le Moal, Werner Zimmerli, Javier Ariza
Background.: Streptococci are not an infrequent cause of periprosthetic joint infection (PJI). Management by debridement, antibiotics, and implant retention (DAIR) is thought to produce a good prognosis, but little is known about the real likelihood of success. Methods.: A retrospective, observational, multicenter, international study was performed during 2003-2012. Eligible patients had a streptococcal PJI that was managed with DAIR. The primary endpoint was failure, defined as death related to infection, relapse/persistence of infection, or the need for salvage therapy...
June 15, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28073672/the-long-story-of-camptothecin-from-traditional-medicine-to-drugs
#11
REVIEW
Emanuela Martino, Serena Della Volpe, Elisa Terribile, Emanuele Benetti, Mirena Sakaj, Adriana Centamore, Andrea Sala, Simona Collina
20-(S)-Camptothecin (CPT) is a natural alkaloid extracted from the bark of Camptotheca acuminata (Chinese happy tree). It acts as a DNA topoisomerase 1 poison with an interesting antitumor activity and its use is limited by low stability and solubility and unpredictable drug-drug interactions. Since the late 20th century, it has been widely used in cancer therapy and, since extraction yields from plant tissues are very low, various synthetic routes have been developed to satisfy the increase in demand for CPT...
February 15, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/27984850/development-of-endometrioid-adenocarcinoma-despite-levonorgestrel-releasing-intrauterine-system-a-case-report-with-discussion-and-review-of-the-rcog-bsge-guideline-on-the-management-of-endometrial-hyperplasia
#12
A C L van der Meer, L S Hanna
Obesity is a significant risk factor for the development of endometrial hyperplasia and cancer. More conservative prevention and management strategies are attractive due to the increased surgical risk and complication rates associated with obesity. The Levonorgestrel-releasing intrauterine system (LNG-IUS, Mirena) has been shown to reduce the risk of developing endometrial cancer. The recent joint Green Top Guideline on the Management of Endometrial Hyperplasia published by the Royal College of Obstetricians and Gynaecologists (RCOG) with the British Society for Gynaecological Endoscopy (BSGE) recommends the LNG-IUS for the medical management of endometrial hyperplasia without atypia...
February 2017: Clinical Obesity
https://www.readbyqxmd.com/read/27972330/comparison-of-mirena-intrauterine-device-with-oral-progesterone-treatment-and-surgical-treatment-in-idiopathic-menorrhagia-patients-results-of-a-cost-minimisation-analysis
#13
N Buyuktuna, F Sumer
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/27871920/integrating-long-acting-reversible-contraception-services-into-new-york-city-school-based-health-centers-quality-improvement-to-ensure-provision-of-youth-friendly-services
#14
Manaswi Sangraula, Samantha Garbers, Janet Garth, Emily Birchfield Shakibnia, Sarah Timmons, Melanie A Gold
STUDY OBJECTIVE, DESIGN, AND SETTING: Adolescents face barriers to accessing youth-friendly family planning services, specifically long-acting reversible contraception (LARC). School-based health centers (SBHCs) can provide youth-friendly care. A quality improvement project was undertaken to assess quality of care before, during, and after LARC services at 3 SBHCs, and to identify specific strategies for improving these LARC services. PARTICIPANTS, INTERVENTIONS, AND MAIN OUTCOME MEASURES: We interviewed 18 female adolescents who received LARC services...
June 2017: Journal of Pediatric and Adolescent Gynecology
https://www.readbyqxmd.com/read/27743678/chlamydia-trachomatis-re-infection-in-spain-a-sti-clinic-based-cohort-study
#15
Josefina López-de-Munain, Maria Del Mar Cámara-Pérez, Manuel Imaz-Pérez, Javier Pereda-Berroeta, Iñigo López-Azcarreta, Josefa Muñoz-Sánchez, Ramón Cisterna-Cáncer, Oscar Luis Ferrero-Beneitez, Sofia Ibarra-Ugarte, Zuriñe Zubero-Sulibarria, Josu Mirena Baraia-Etxaburu Artetxe
BACKGROUND: Chlamydia trachomatis (C. trachomatis) is the most frequently reported sexually transmitted infection (STI) in developed countries, but there is a lack data on its incidence and population dynamics in Spain. The objectives of this study were to estimate the incidence of C. trachomatis in patients seeking medical attention in an STI clinic with a defined population catchment area, to identify factors associated with this infection, and to explore differences between factors associated with new infections and re-infections...
March 2017: Enfermedades Infecciosas y Microbiología Clínica
https://www.readbyqxmd.com/read/27678781/hysteroscopic-removal-of-malpositioned-mirena-iud-embedded-in-cesarean-scar-niche
#16
R Sangha, S Talukdar
No abstract text is available yet for this article.
November 2015: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/27597909/bleeding-versus-clotting-a-complex-case-of-a-large-fibroid-uterus-causing-menorrhagia-and-a-dvt
#17
Sangeeta Ramanan, Jude Chapman-Wardy, Roy Watson
A 43-year-old woman presented with severe anaemia secondary to menorrhagia. Pelvic ultrasound showed a large intramural posterior fundal fibroid. Hysteroscopy showed the fibroid distorting the endometrial cavity, precluding Mirena® device insertion. As she was initially hesitant to have a hysterectomy, medical management with the oral contraceptive pill (OCP) and tranexamic acid was instituted, with good effect. Months later, after a long road trip, she presented with left leg swelling, and a Doppler ultrasound confirmed an extensive deep vein thrombosis (DVT)...
2016: Case Reports in Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27554014/two-week-postpartum-intrauterine-contraception-insertion-a-study-of-feasibility-patient-acceptability-and-short-term-outcomes
#18
Matthew L Zerden, Gretchen S Stuart, Samantha Charm, Amy Bryant, Joanne Garrett, Jessica Morse
OBJECTIVE: To determine the feasibility and acceptability of inserting the levonorgestrel intrauterine system, LNG 52 mg IUS (LNG IUS), at 2 weeks postpartum. STUDY DESIGN: This prospective study of feasibility and patient acceptability recruited women interested in a postpartum LNG IUS and placed the LNG IUS under ultrasound guidance on days 14-20 postpartum. We determined feasibility by our ability to recruit and insert the LNG IUS in our predetermined sample size of 50 women...
January 2017: Contraception
https://www.readbyqxmd.com/read/27549429/retrospective-analysis-of-the-impact-of-increasing-access-to-long-acting-reversible-contraceptives-in-a-commercially-insured-population
#19
Amy Law, Dominic Pilon, Richard Lynen, François Laliberté, Laurence Gozalo, Patrick Lefebvre, Mei Sheng Duh
BACKGROUND: Unintended pregnancies have been shown to be associated with high costs for the healthcare system, among other adverse impacts, but could still account for up to 51 % of pregnancies in the US. Improvements in contraception among women are needed. Long acting reversible contraceptives (LARCs), which have proved their safety and efficacy, have been found to significantly decrease the risk of unintended pregnancy. Yet they are still marginally employed. This study aims at investigating the evolution of LARC use over 15 years and at assessing the impact of the introduction of newer LARCs on LARC use relative to all contraceptive use...
August 22, 2016: Reproductive Health
https://www.readbyqxmd.com/read/27524103/short-versus-long-duration-levofloxacin-plus-rifampicin-for-acute-staphylococcal-prosthetic-joint-infection-managed-with-implant-retention-a-randomised-clinical-trial
#20
RANDOMIZED CONTROLLED TRIAL
Jaime Lora-Tamayo, Gorane Euba, Javier Cobo, Juan Pablo Horcajada, Alex Soriano, Enrique Sandoval, Carles Pigrau, Natividad Benito, Luis Falgueras, Julián Palomino, María Dolores Del Toro, Alfredo Jover-Sáenz, José Antonio Iribarren, Mar Sánchez-Somolinos, Antonio Ramos, Marta Fernández-Sampedro, Melchor Riera, Josu Mirena Baraia-Etxaburu, Javier Ariza
Levofloxacin plus rifampicin (L+R) is the treatment of choice for acute staphylococcal prosthetic joint infection (PJI) managed with debridement and implant retention (DAIR). Long courses have been empirically recommended, but some studies have suggested that shorter treatments could be as effective. Our aim was to prove that a short treatment schedule was non-inferior to the standard long schedule. An open-label, multicentre, randomised clinical trial (RCT) was performed. Patients with an early post-surgical or haematogenous staphylococcal PJI, managed with DAIR and initiated on L+R were randomised to receive 8 weeks of treatment (short schedule) versus a long schedule (3 months or 6 months for hip or knee prostheses, respectively)...
September 2016: International Journal of Antimicrobial Agents
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