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https://www.readbyqxmd.com/read/28488383/pax6-allelic-heterogeneity-in-mexican-congenital-aniridia-patients-expanding-the-mutational-spectrum-with-7-novel-pathogenic-variants
#1
Sofía Pérez-Solórzano, Oscar F Chacón-Camacho, Mirena C Astiazarán, Gerardo Ledesma-Gil, Juan Carlos Zenteno
IMPORTANCE: To describe the clinical characteristics and mutational analysis of Mexican patients with aniridia and PAX6 mutations. BACKGROUND: Aniridia is a panocular hereditary eye disease caused by mutations in the PAX6 transcription factor. Mutation detection rate is highly variable ranging from 30 to 90% in different populations. Very few studies have been published about the PAX6 mutational analysis in aniridia patients from Mexico. In order to establish a more representative PAX6 mutational frequency in the country, a cohort of 22 Mexican unrelated aniridia probands were analyzed in this study...
May 9, 2017: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/28369296/the-not-so-good-prognosis-of-streptococcal-periprosthetic-joint-infection-managed-by-implant-retention-the-results-of-a-large-multicenter-study
#2
Jaime Lora-Tamayo, Éric Senneville, Alba Ribera, Louis Bernard, Michel Dupon, Valérie Zeller, Ho Kwong Li, Cédric Arvieux, Martin Clauss, Ilker Uçkay, Dace Vigante, Tristan Ferry, José Antonio Iribarren, Trisha N Peel, Parham Sendi, Nina Gorišek Miksic, Dolors Rodríguez-Pardo, María Dolores Del Toro, Marta Fernández-Sampedro, Ulrike Dapunt, Kaisa Huotari, Joshua S Davis, Julián Palomino, Danielle Neut, Benjamin M Clark, Thomas Gottlieb, Rihard Trebše, Alex Soriano, Alberto Bahamonde, Laura Guío, Alicia Rico, Mauro Jc Salles, M José G Pais, Natividad Benito, Melchor Riera, Lucía Gómez, Craig A Aboltins, Jaime Esteban, Juan Pablo Horcajada, Karina O'Connell, Matteo Ferrari, Gábor Skaliczki, Rafael San Juan, Javier Cobo, Mar Sánchez-Somolinos, Antonio Ramos, Efthymia Giannitsioti, Alfredo Jover-Sáenz, Josu Mirena Baraia-Etxaburu, José María Barbero, Peter F M Choong, Nathalie Asseray, Séverine Ansart, Gwenäel Le Moal, Werner Zimmerli, Javier Ariza
Background: Streptococci are not an infrequent cause of periprosthetic joint infection (PJI). Management by debridement, antibiotics, and implant retention (DAIR) is thought to produce a good prognosis, but little is known about the real likelihood of success. Methods: Retrospective, observational, multicenter, international study performed during 2003-2012. Eligible patients had a streptococcal PJI that was managed with DAIR. The primary endpoint was failure, defined as death related to infection, relapse/persistence of infection, or the need for salvage therapy...
March 23, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28073672/the-long-story-of-camptothecin-from-traditional-medicine-to-drugs
#3
REVIEW
Emanuela Martino, Serena Della Volpe, Elisa Terribile, Emanuele Benetti, Mirena Sakaj, Adriana Centamore, Andrea Sala, Simona Collina
20-(S)-Camptothecin (CPT) is a natural alkaloid extracted from the bark of Camptotheca acuminata (Chinese happy tree). It acts as a DNA topoisomerase 1 poison with an interesting antitumor activity and its use is limited by low stability and solubility and unpredictable drug-drug interactions. Since the late 20th century, it has been widely used in cancer therapy and, since extraction yields from plant tissues are very low, various synthetic routes have been developed to satisfy the increase in demand for CPT...
December 31, 2016: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/27984850/development-of-endometrioid-adenocarcinoma-despite-levonorgestrel-releasing-intrauterine-system-a-case-report-with-discussion-and-review-of-the-rcog-bsge-guideline-on-the-management-of-endometrial-hyperplasia
#4
A C L van der Meer, L S Hanna
Obesity is a significant risk factor for the development of endometrial hyperplasia and cancer. More conservative prevention and management strategies are attractive due to the increased surgical risk and complication rates associated with obesity. The Levonorgestrel-releasing intrauterine system (LNG-IUS, Mirena) has been shown to reduce the risk of developing endometrial cancer. The recent joint Green Top Guideline on the Management of Endometrial Hyperplasia published by the Royal College of Obstetricians and Gynaecologists (RCOG) with the British Society for Gynaecological Endoscopy (BSGE) recommends the LNG-IUS for the medical management of endometrial hyperplasia without atypia...
February 2017: Clinical Obesity
https://www.readbyqxmd.com/read/27972330/comparison-of-mirena-intrauterine-device-with-oral-progesterone-treatment-and-surgical-treatment-in-idiopathic-menorrhagia-patients-results-of-a-cost-minimisation-analysis
#5
N Buyuktuna, F Sumer
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/27871920/integrating-long-acting-reversible-contraception-services-into-new-york-city-school-based-health-centers-quality-improvement-to-ensure-provision-of-youth-friendly-services
#6
Manaswi Sangraula, Samantha Garbers, Janet Garth, Emily Birchfield Shakibnia, Sarah Timmons, Melanie A Gold
STUDY OBJECTIVE, DESIGN, AND SETTING: Adolescents face barriers to accessing youth-friendly family planning services, specifically long-acting reversible contraception (LARC). School-based health centers (SBHCs) can provide youth-friendly care. A quality improvement project was undertaken to assess quality of care before, during, and after LARC services at 3 SBHCs, and to identify specific strategies for improving these LARC services. PARTICIPANTS, INTERVENTIONS, AND MAIN OUTCOME MEASURES: We interviewed 18 female adolescents who received LARC services...
November 18, 2016: Journal of Pediatric and Adolescent Gynecology
https://www.readbyqxmd.com/read/27743678/chlamydia-trachomatis-re-infection-in-spain-a-sti-clinic-based-cohort-study
#7
Josefina López-de-Munain, Maria Del Mar Cámara-Pérez, Manuel Imaz-Pérez, Javier Pereda-Berroeta, Iñigo López-Azcarreta, Josefa Muñoz-Sánchez, Ramón Cisterna-Cáncer, Oscar Luis Ferrero-Beneitez, Sofia Ibarra-Ugarte, Zuriñe Zubero-Sulibarria, Josu Mirena Baraia-Etxaburu Artetxe
BACKGROUND: Chlamydia trachomatis (C. trachomatis) is the most frequently reported sexually transmitted infection (STI) in developed countries, but there is a lack data on its incidence and population dynamics in Spain. The objectives of this study were to estimate the incidence of C. trachomatis in patients seeking medical attention in an STI clinic with a defined population catchment area, to identify factors associated with this infection, and to explore differences between factors associated with new infections and re-infections...
March 2017: Enfermedades Infecciosas y Microbiología Clínica
https://www.readbyqxmd.com/read/27678781/hysteroscopic-removal-of-malpositioned-mirena-iud-embedded-in-cesarean-scar-niche
#8
R Sangha, S Talukdar
No abstract text is available yet for this article.
November 2015: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/27597909/bleeding-versus-clotting-a-complex-case-of-a-large-fibroid-uterus-causing-menorrhagia-and-a-dvt
#9
Sangeeta Ramanan, Jude Chapman-Wardy, Roy Watson
A 43-year-old woman presented with severe anaemia secondary to menorrhagia. Pelvic ultrasound showed a large intramural posterior fundal fibroid. Hysteroscopy showed the fibroid distorting the endometrial cavity, precluding Mirena® device insertion. As she was initially hesitant to have a hysterectomy, medical management with the oral contraceptive pill (OCP) and tranexamic acid was instituted, with good effect. Months later, after a long road trip, she presented with left leg swelling, and a Doppler ultrasound confirmed an extensive deep vein thrombosis (DVT)...
2016: Case Reports in Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27554014/two-week-postpartum-intrauterine-contraception-insertion-a-study-of-feasibility-patient-acceptability-and-short-term-outcomes
#10
Matthew L Zerden, Gretchen S Stuart, Samantha Charm, Amy Bryant, Joanne Garrett, Jessica Morse
OBJECTIVE: To determine the feasibility and acceptability of inserting the levonorgestrel intrauterine system, LNG 52 mg IUS (LNG IUS), at 2 weeks postpartum. STUDY DESIGN: This prospective study of feasibility and patient acceptability recruited women interested in a postpartum LNG IUS and placed the LNG IUS under ultrasound guidance on days 14-20 postpartum. We determined feasibility by our ability to recruit and insert the LNG IUS in our predetermined sample size of 50 women...
January 2017: Contraception
https://www.readbyqxmd.com/read/27549429/retrospective-analysis-of-the-impact-of-increasing-access-to-long-acting-reversible-contraceptives-in-a-commercially-insured-population
#11
Amy Law, Dominic Pilon, Richard Lynen, François Laliberté, Laurence Gozalo, Patrick Lefebvre, Mei Sheng Duh
BACKGROUND: Unintended pregnancies have been shown to be associated with high costs for the healthcare system, among other adverse impacts, but could still account for up to 51 % of pregnancies in the US. Improvements in contraception among women are needed. Long acting reversible contraceptives (LARCs), which have proved their safety and efficacy, have been found to significantly decrease the risk of unintended pregnancy. Yet they are still marginally employed. This study aims at investigating the evolution of LARC use over 15 years and at assessing the impact of the introduction of newer LARCs on LARC use relative to all contraceptive use...
August 22, 2016: Reproductive Health
https://www.readbyqxmd.com/read/27524103/short-versus-long-duration-levofloxacin-plus-rifampicin-for-acute-staphylococcal-prosthetic-joint-infection-managed-with-implant-retention-a-randomised-clinical-trial
#12
RANDOMIZED CONTROLLED TRIAL
Jaime Lora-Tamayo, Gorane Euba, Javier Cobo, Juan Pablo Horcajada, Alex Soriano, Enrique Sandoval, Carles Pigrau, Natividad Benito, Luis Falgueras, Julián Palomino, María Dolores Del Toro, Alfredo Jover-Sáenz, José Antonio Iribarren, Mar Sánchez-Somolinos, Antonio Ramos, Marta Fernández-Sampedro, Melchor Riera, Josu Mirena Baraia-Etxaburu, Javier Ariza
Levofloxacin plus rifampicin (L+R) is the treatment of choice for acute staphylococcal prosthetic joint infection (PJI) managed with debridement and implant retention (DAIR). Long courses have been empirically recommended, but some studies have suggested that shorter treatments could be as effective. Our aim was to prove that a short treatment schedule was non-inferior to the standard long schedule. An open-label, multicentre, randomised clinical trial (RCT) was performed. Patients with an early post-surgical or haematogenous staphylococcal PJI, managed with DAIR and initiated on L+R were randomised to receive 8 weeks of treatment (short schedule) versus a long schedule (3 months or 6 months for hip or knee prostheses, respectively)...
September 2016: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/27187927/the-use-of-long-acting-reversible-contraceptives-and-the-relationship-between-discontinuation-rates-due-to-menopause-and-to-female-and-male-sterilizations
#13
Jessica Mayra Ferreira, Ilza Monteiro, Sara Castro, Marina Villarroel, Carolina Silveira, Luis Bahamondes
Introduction Women require effective contraception until they reach menopause. The long acting reversible contraceptives (LARC) and the depot-medroxyprogesterone acetate (DMPA, Depo-Provera®, Pfizer, Puurs, Belgium) are great options and can replace possible sterilizations. Purpose To assess the relationship between the use of LARCs and DMPA and terminations ascribed to menopause and sterilizations in a Brazilian clinic. Methods We reviewed the records of women between 12 and 50 years of age attending the clinic that chose to use a LARC method or DMPA...
May 2016: Revista Brasileira de Ginecologia e Obstetrícia
https://www.readbyqxmd.com/read/27181408/time-trends-in-the-aetiology-of-prosthetic-joint-infections-a-multicentre-cohort-study
#14
MULTICENTER STUDY
N Benito, M Franco, A Ribera, A Soriano, D Rodriguez-Pardo, L Sorlí, G Fresco, M Fernández-Sampedro, M Dolores Del Toro, L Guío, E Sánchez-Rivas, A Bahamonde, M Riera, J Esteban, J M Baraia-Etxaburu, J Martínez-Alvarez, A Jover-Sáenz, C Dueñas, A Ramos, B Sobrino, G Euba, L Morata, C Pigrau, P Coll, I Mur, J Ariza
It is important to know the spectrum of the microbial aetiology of prosthetic joint infections (PJIs) to guide empiric treatment and establish antimicrobial prophylaxis in joint replacements. There are no available data based on large contemporary patient cohorts. We sought to characterize the causative pathogens of PJIs and to evaluate trends in the microbial aetiology. We hypothesized that the frequency of antimicrobial-resistant organisms in PJIs has increased in the recent years. We performed a cohort study in 19 hospitals in Spain, from 2003 to 2012...
August 2016: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/27179741/corrigendum-to-the-brazilian-cardioprotective-nutritional-program-to-reduce-events-and-risk-factors-in-secondary-prevention-for-cardiovascular-disease-study-protocol-the-balance-program-trial-american-heart-journal-171-1-2016-73-81
#15
Bernardete Weber, Ângela C Bersch-Ferreira, Camila R Torreglosa, Maria B Ross-Fernandes, Jacqueline T da Silva, Andrea P Galante, Enilda de Sousa Lara, Rosana P Costa, Rafael M Soares, Alexandre B Cavalcanti, Emilio H Moriguchi, Neide M Bruscato, Josiele Kesties, Lilian Vivian, Marina Schumacher, Waldemar de Carli, Luciano M Backes, Bruna R Reolão, Milena P Rodrigues, Dúnnia M B Baldissera, Glaucia S Tres, Hugo R K Lisbôa, João B J Bem, Jose B C Reolão, Keyla L A L Deucher, Maiara Cantarelli, Aline Lucion, Daniela Rampazzo, Vanessa Bertoni, Rosileide S Torres, Adriana O L Verríssimo, Aldair S Guterres, Andrea F R Cardos, Dalva B S Coutinho, Mayara G Negrão, Mônica F A Alencar, Priscila M Pinho, Socorro N A A Barbosa, Ana P P F Carvalho, Maria I S Taboada, Sheila A Pereira, Raul V Heyde, Francisca E Z Nagano, Rebecca Baumgartner, Fernanda P Resende, Ranata Tabalipa, Ana C Zanini, Michael J R Machado, Hevila Araujo, Maria L V Teixeira, Gabriela C Souza, Priccila Zuchinali, Bianca M Fracasso, Karen Ulliam, Marina Schumacher, Moara Pierotto, Thamires Hilário, Daniele M O Carlos, Cintia G N C Cordeiro, Daniele A Carvalho, Marília S Gonçalves, Valdiana B Vasconcelos, Rosa Bosquetti, Raira Pagano, Marcelo L P Romano, César A Jardim, Bernardo N A de Abreu, Aline Marcadenti, Alessandra R Schmitt, Angela M V Tavares, Christiane C Faria, Flávia M Silva, Jaqueline S Fink, Raquel M El Kik, Clarice F Prates, Cristiane S Vieira, Elaine F Adorne, Ellen H Magedanz, Fernanda L Chieza, Ingrid S Silva, Joise M Teixeira, Eduardo P Trescastro, Lívia A Pellegrini, Jéssika C Pinto, Cristina T Telles, Antonio C S Sousa, Andreza S Almeida, Ariane A Costa, José A C Carmo, Juliana T Silva, Luciana V S Alves, Saulo O C Sales, Maria E M Ramos, Marilia C S Lucas, Monica Damiani, Patricia C Cardoso, Salvador S Ramos, Clenise F Dantas, Amanda G Lopes, Ana M P Cabral, Ana C A Lucena, Auriene L Medeiros, Bernardino B Terceiro, Neuma M F S Leda, Sandra R D Baía, Josilene M F Pinheiro, Alexandra N Cassiano, Andressa N L Melo, Anny K O Cavalcanti, Camila V S Souza, Dayanna J M Queiroz, Hercilla N C F Farias, Larissa C F Souza, Letícia S Santos, Luana R M Lima, Meg S Hoffmann, Átala S Silva Ribeiro, Daniel F Vasconcelos, Eliane S Dutra, Marina K Ito, José A F Neto, Alexsandro F Santos, Rosângela M L Sousa, Luciana Pereira P Dias, Maria T M A Lima, Victor G Modanesi, Adriana F Teixeira, Luciana C N C D Estrada, Paulo V G Modanesi, Adriana B L Gomes, Bárbara R S Rocha, Cristina Teti, Marta M David, Bruna M Palácio, Délcio G S Junior, Érica H S Faria, Michelle C F Oliveira, Rose M Uehara, Sandramara Sasso, Annie S B Moreira, Ana C A H Cadinha, Carla W M Pinto, Mariana P Castilhos, Mariana Costa, Cristiane Kovacs, Daniel Magnoni, Quênia Silva, Michele F C A Germini, Renata A da Silva, Aline S Monteiro, Karina G Dos Santos, Priscila Moreira, Fernanda C Amparo, Catharina C J Paiva, Soraia Poloni, Diana S Russo, Izabele V Silveira, Maria A Moraes, Mirena Boklis, Quinto I Cardoso, Annie S B Moreira, Aline M S Damaceno, Elisa M Santos, Glauber M Dias, Cláudia P S Pinho, Adrilene C Cavalcanti, Amanda S Bezerra, Andrey V Queiroga, Isa G Rodrigues, Tallita V Leal, Viviane Sahade, Daniele A Amaral, Diana S Souza, Givaldo A Araújo, Karine Curvello, Manuella Heine, Marília M S Barretto, Nailson A Reis, Sandra M L Vasconcelos, Danielly C Vieira, Francisco A Costa, Jessica M S Fontes, Juvenal G C Neto, Laís N P Navarro, Raphaela C Ferreira, Patrícia M Marinho, Renata Torres Abib, Aline Longo, Eduardo G Bertoldi, Lauren S Ferreira, Lúcia R Borges, Norlai A Azevedo, Celma M Martins, Juliana T Kato, Maria C O Izar, Marina T Asoo, Mariana D de Capitani, Valéria A Machado, Waléria T Fonzar, Sônia L Pinto, Kellen C Silva, Lúcia H A Gratão, Sheila D Machado, Susane R U de Oliveira, Josefina Bressan, Ana P S Caldas, Hatanne C F M Lima, Helen H M Hermsdorff, Tânia M Saldanha, Sílvia E Priore, Naoel H Feres, Adila de Queiroz Neves, Loanda M G Cheim, Nilma F Silva, Silvia R L Reis, Andreza M Penafort, Ana Paula O de Queirós, Geysa M N Farias, Mônica L P de Los Santos, Cíntia L Ambrozio, Cirília N Camejo, Cristiano P Dos Santos, Gabriela S Schirmann, Jorge L Boemo, Rosane E C Oliveira, Súsi M B Lima, Vera M S Bortolini, Cristina H Matos, Claiza Barretta, Clarice M Specht, Simone R de Souza, Cristina S Arruda, Priscila A Rodrigues, Otávio Berwanger
No abstract text is available yet for this article.
May 2016: American Heart Journal
https://www.readbyqxmd.com/read/27172400/declining-rates-of-sterilization-procedures-in-western-australian-women-from-1990-to-2008-the-relationship-with-age-hospital-type-and-government-policy-changes
#16
Khadra A Jama-Alol, Alexandra P Bremner, Louise M Stewart, Anna Kemp-Casey, Eva Malacova, Rachael Moorin, Adeleh Shirangi, David B Preen
OBJECTIVE: To describe trends in age-specific incidence rates of female sterilization (FS) procedures in Western Australia and to evaluate the effects of the introduction of government-subsidized contraceptive methods and the implementation of the Australian government's baby bonus policy on FS rates. DESIGN: Population-based retrospective descriptive study. SETTING: Not applicable. PATIENT(S): All women ages 15-49 undergoing an FS procedure during the period January 1, 1990, to December 31, 2008 (n = 47,360 procedures)...
September 1, 2016: Fertility and Sterility
https://www.readbyqxmd.com/read/26769874/patient-or-clinician-duration-of-use-of-intrauterine-devices-based-on-who-initiated-discussion-of-placement
#17
Tammy Chang, Michelle H Moniz, Melissa A Plegue, Kathryn Sage Shaffer, Heather B Vance, Katherine J Gold
BACKGROUND: Although safe and effective, intrauterine devices (IUDs) are underutilized in the United States. The objective of this study was to determine whether patient- and clinician-initiated discussions were associated with the duration of Mirena (52 mg levonorgestrel-releasing) IUD use. METHODS: Retrospective chart review identified Mirena IUDs that were placed and removed for reasons other than the desire for pregnancy from January 1, 2005, to January 1, 2012, at 1 academic center (n = 148)...
January 2016: Journal of the American Board of Family Medicine: JABFM
https://www.readbyqxmd.com/read/26672176/-contraception-during-the-perimenopause-indications-security-and-non-contraceptive-benefits
#18
P Cantero Pérez, J Klingemann, M Yaron, N Fournet Irion, I Streuli
Although patients' fertility is diminished in the period of perimenopause, they still need efficient contraception. Thorough knowledge of the physiological changes occuring during this period of transition is essential in order to provide optimal care. Until the age of 50, no contraceptive method is specifically considered unsuitable due to age alone. The choice of contraceptive needs to be adapted to the patient, assessing the individual risk factors and favouring the potential non-contraceptive advantages of the method selected...
October 28, 2015: Revue Médicale Suisse
https://www.readbyqxmd.com/read/26630538/relapse-risk-of-endometrial-hyperplasia-after-treatment-with-the-levonorgestrel-impregnated-intrauterine-system-or-oral-progestogens
#19
A Ørbo, M Arnes, A B Vereide, B Straume
OBJECTIVE: To investigate relapse rates after the successful treatment of patients with non-atypical endometrial hyperplasia who were randomised to either a levonorgestrel-impregnated intrauterine system (LNG-IUS; Mirena(®) ) or two regimens of oral medroxyprogesterone acetate (MPA) after primary histological response. DESIGN: A multicentre randomised trial. SETTING: Ten different outpatient clinics localised in hospitals and seven gynaecological private practices in Norway...
August 2016: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/26626534/long-acting-hormonal-contraception
#20
REVIEW
Giuseppe Benagiano, Henry Gabelnick, Ivo Brosens
Today, a new category of fertility-regulating agents has been created: long-acting, reversible hormonal contraceptives; they minimize compliance, while maximize effectiveness. They comprise subdermal implants and intrauterine devices. Other long-acting agents exist, such as Depo Provera and Noristerat. Use of Depo Provera and Noristerat carries great effectiveness, good clinical safety and usefulness in developing countries. They cause no significant increase in breast cancer risk, but they may carry an increased risk of HIV...
November 2015: Women's Health
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