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https://www.readbyqxmd.com/read/29909089/safety-of-laparoscopic-surgery-for-benign-diseases-during-pregnancy-a-nationwide-retrospective-cohort-study
#1
Daisuke Shigemi, Shotaro Aso, Hiroki Matsui, Kiyohide Fushimi, Hideo Yasunaga
STUDY OBJECTIVE: To compare fetal, maternal, and operative outcomes of laparoscopic surgery versus laparotomy for major benign diseases including appendicitis, cholecystitis, adnexal masses, and uterine myoma during pregnancy. DESIGN: Retrospective cohort study (Canadian Task Force classification II-2). SETTING: The Diagnosis Procedure Combination database, a national inpatient database for acute-care inpatients in Japan. PATIENTS: 6,018 eligible patients underwent abdominal surgery (4,047 laparotomy and 1,971 laparoscopy patients) from July 2010 through March 2016...
June 14, 2018: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29900760/anaplastic-lymphoma-kinase-negative-uterine-inflammatory-myofibroblastic-tumor-containing-the-etv6-ntrk3-fusion-gene-a-case-report
#2
Akimasa Takahashi, Manabu Kurosawa, Mao Uemura, Jun Kitazawa, Yoshihiko Hayashi
Inflammatory myofibroblastic tumors (IMTs) are neoplasms with low malignant potential, and the most common tumor in the lung and orbit. Their occurrence in the uterus is rare. Approximately 50% of IMT patients have anaplastic lymphoma kinase gene ( ALK) rearrangements. Recent studies described novel fusions involving ROS1, platelet-derived growth factor receptor beta ( PDGFR-β), and ETS translocation variant ( ETV6) genes in a subset of ALK-negative patients. We report a 44-year-old woman with anemia and uterine IMT...
January 1, 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/29891843/establishment-of-a-novel-mouse-xenograft-model-of-human-uterine-leiomyoma
#3
Yusuke Suzuki, Masaaki Ii, Takashi Saito, Yoshito Terai, Yasuhiko Tabata, Masahide Ohmichi, Michio Asahi
Uterine leiomyoma is the most common benign tumour in women, and an appropriate animal model for leiomyoma would be useful for exploring new therapeutic strategies. Therefore, we have been challenged to develop a new simple mouse model for human leiomyoma. Leiomyoma tissues were harvested from myomas resected by different surgical procedures with or without gonadotropin-releasing hormone agonist (GnRHa) treatment and were subcutaneously implanted into BALB/c nude mice with an estradiol/progesterone-releasing pellet...
June 11, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29888280/risk-factors-for-the-completion-of-the-cold-loop-hysteroscopic-myomectomy-in-a-one-step-procedure-a-post-hoc-analysis
#4
Ivan Mazzon, Alessandro Favilli, Mario Grasso, Stefano Horvath, Vittorio Bini, Gian Carlo Di Renzo, Sandro Gerli
Introduction: The aim of the study was to analyze which variables influenced the completion of a cold loop hysteroscopic myomectomy in a one-step procedure in a large cohort of patients. Materials and Methods: A retrospective cohort study of 1434 cold loop resectoscopic myomectomies consecutively performed. The study population was divided into two groups according to the number of procedures needed to accomplish the treatment. Variables influencing the completion of hysteroscopic myomectomy in a one-step procedure were investigated...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29852335/epidemiology-of-uterine-myomas-and-clinical-practice-in-spain-an-observational-study
#5
Javier Monleón, María Luisa Cañete, Virginia Caballero, Manuel Del Campo, Alejandro Doménech, Miguel Ángel Losada, Joaquim Calaf
OBJECTIVE: Characterization of the clinical features of symptomatic uterine myomas in Spanish women visiting the gynaecologist, including impact on quality of life and possible risk factors, description of main therapeutic approaches, and evaluation of symptom and quality of life progression 6 months after inclusion in the study. STUDY DESIGN: This was an observational, epidemiological, non-interventional, multicentre study performed between June 2015 and March 2016...
May 21, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29850316/management-of-a-pregnancy-with-a-solid-pseudopapillary-neoplasm-of-the-pancreas
#6
Atakan Tanacan, Gokcen Orgul, Ahmet Bülent Dogrul, Fatih Aktoz, Osman Abbasoglu, M Sinan Beksac
A 26-year-old primigravid patient, at 35 weeks and 2 days of gestation, was referred to Hacettepe University Hospital for pancreatic mass, giant cervical myoma, maternal systemic lupus erythematosus, thrombocytopenia, and onset of preterm labor. At 36 weeks and 1 day of gestation (6 days after admission to the hospital), regular uterine contractions started and cervical dilatation with effacement was observed. Because of breech presentation and giant cervical myoma, a cesarean section was performed on the primigravid patient under general anesthesia...
2018: Case Reports in Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29807764/gene-expression-changes-in-uterine-myomas-in-response-to-ulipristal-acetate-treatment
#7
Guillaume E Courtoy, Jacques Donnez, Jérôme Ambroise, Pablo Arriagada, Mathieu Luyckx, Etienne Marbaix, Marie-Madeleine Dolmans
RESEARCH QUESTION: Does ulipristal acetate (UPA) modify the expression of genes related to apoptosis or the extracellular matrix in uterine myomas and are any modifications associated with a clinical response? DESIGN: Targeted analysis of 176 apoptosis- or extracellular-matrix-related genes was conducted using polymerase chain reaction (PCR) arrays. Relevant results were validated by quantitative PCR. Four groups were established: responsive short-term (one course, n = 9), responsive long-term (two to four courses, n = 9), non-responsive (n = 9), and the control group who was not given any hormone therapy (n = 9)...
May 7, 2018: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/29789793/modern-myoma-treatment-in-the-last-20-years-a-review-of-the-literature
#8
REVIEW
Ahmed El-Balat, Rudy Leon DeWilde, Iryna Schmeil, Morva Tahmasbi-Rad, Sandra Bogdanyova, Ali Fathi, Sven Becker
Myomas, also known as fibroids, are a specific characteristic of the human species. No other primates develop fibroids. At a cellular level, myomas are benign hyperplastic lesions of uterine smooth muscle cells. There are interesting theoretical concepts that link the development of myomas in humans with the highly specific process of childbirth from an upright position and the resulting need for greatly increased "expulsive" forces during labor. Myomas might be the price our species pays for our bipedal and highly intelligent existence...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29786043/risk-factors-for-recurrence-of-ovarian-endometriosis-in-chinese-patients-aged-45-and-over
#9
Zheng-Xing He, Ting-Ting Sun, Shu Wang, Hong-Hui Shi, Qing-Bo Fan, Lan Zhu, Jin-Hua Leng, Da-Wei Sun, Jian Sun, Jing-He Lang
Background: When considering the issue of recurrence, perimenopausal women may have more dilemma during management comparing with young women, for example, whether to retain the uterus and ovary during surgery, whether it is necessary to add adjuvant medicine treatment after operation, and there is no evidence for reference about using of gonadotropin-releasing hormone agonist. This study aimed to study the risk factors for the recurrence of ovarian endometriosis (EM) in patients aged 45 and over...
June 5, 2018: Chinese Medical Journal
https://www.readbyqxmd.com/read/29772408/hysteroscopic-myomectomy-of-a-large-submucosal-leiomyoma-with-novel-use-of-fluid-warming
#10
Tess Chase, Stephanie J Estes
Uterine fibroid size is often considered a limiting factor for considering the surgical approach to myomectomy. In this case, a 35-year-old woman presented with heavy menstrual bleeding and desire for fertility. An ultrasound three months prior could not assess the endometrium and suggested leiomyoma. Magnetic resonance imaging of the pelvis identified a fundal submucosal myoma measuring 6.8 × 7.1 × 3.5 cm. A planned staged hysteroscopic resection of the large submucosal fibroid with intramural component was achieved...
May 14, 2018: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29765929/gonadotropin-releasing-hormone-agonist-plus-aromatase-inhibitor-in-the-treatment-of-uterine-leiomyoma-in-near-menopause-patient-a-case-series-study
#11
Sanam Moradan
Objectives: There are many drugs for of symptomatic fibroids. Gonadotropin-releasing hormone (GnRH) agonists are the well known drugs. Also, aromatase inhibitors are effective. All published studies surveyed the effect of one of these two drugs. In this study as the first study decided to evaluate the effectiveness of the combination of GnRH agonists + aromatise inhibitor on the uterine fibroids. Methods: A cross-sectional prospective case series study was performed on 10 known cases of uterine fibroids late perimenopause, at least 3 myomas >5 cm, abnormal uterine bleeding and anemia due to fibroids, candidate for hysterectomy, no tendency to surgery...
April 2018: Journal of Menopausal Medicine
https://www.readbyqxmd.com/read/29750109/mediastinal-cysts-with-mullerian-differentiation
#12
Hiroyuki Miura, Jun Miura, Hiroshi Hirano
Mediastinal cysts with Mullerian differentiation are characterized by oestrogen receptor and progesterone receptor positive cell linings. We treated four patients with mediastinal cysts with Mullerian differentiation. All patients were female, from 46 to 52 years old, and had BMIs greater than 26 kg/m2 . All but one patient with cough were asymptomatic. The tumours were located in the paravertebral areas around the Th-1-7 vertebrae. There was no left/right difference. All of the preoperative diagnoses were bronchial cysts...
July 2018: Respirology Case Reports
https://www.readbyqxmd.com/read/29725285/ovarian-endometriosis-risk-factor-analysis-and-prediction-of-malignant-transformation
#13
YanNa Zhou, Ke-Qin Hua
Introduction: For the prediction of endometriosis associated ovarian carcinoma (EAOC), the risk factors for malignant ovarian endometriosis (MOE) were explored. Material and methods: A group of 104 EAOC patients was compared with a group of 104 ovarian endometrial cyst patients. Using single and multivariate risk analysis of EAOC by calculating the area under the curve (AUC) of receiver-operator characteristics (ROC) curves, risks of MOE transformation were calculated for various burdens of risk factors...
March 2018: Przeglad Menopauzalny, Menopause Review
https://www.readbyqxmd.com/read/29718788/vilaprisan-for-treating-uterine-fibroids
#14
Gian Benedetto Melis, Manuela Neri, Bruno Piras, Anna Maria Paoletti, Silvia Ajossa, Monica Pilloni, Maria Francesca Marotto, Valentina Corda, Alessandra Saba, Elena Giancane, Valerio Mais
Introduction The medical strategy to antagonize myoma size and related-symptoms is to reduce estrogen and progesterone activity on myomas. This can be obtained with the GnRH agonist (GnRHa) or with compounds that antagonize progesterone stimulatory activity on myomas. Selective progesterone receptor modulators (SPRMs) bind progesterone receptor (PR), leading to both agonist and antagonist effects. The result of SPRMs's action is tissue-specific and it depends on the particular affinity and strength of each SPRM...
May 2, 2018: Expert Opinion on Investigational Drugs
https://www.readbyqxmd.com/read/29705676/a-case-of-retroperitoneal-desmoid-type-fibromatosis-that-involved-the-unilateral-ureter-after-gynaecologic-surgery
#15
Hitomi Ono, Kensuke Hori, Lena Tashima, Tomohiko Tsuruta, Shin-Ichi Nakatsuka, Kimihiko Ito
INTRODUCTION: Desmoid-type fibromatosis represents a rare, benign, soft tissue tumour that is locally invasive with high recurrence potential. PRESENTATION OF CASE: We encountered a case of retroperitoneal desmoid-type fibromatosis in a 45-year-old woman who presented with chief complaints of stomach ache and vomiting. She underwent total abdominal hysterectomy and left salpingo-oophorectomy due to uterine myoma and a paroophoritic cyst at 42 years of age. Abdominal computed tomography showed a 5-cm left retroperitoneal tumour and severe hydronephrosis of the left kidney...
2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29693945/anestheic-management-of-a-patient-with-intravenous-leiomyomatosis-extending-into-the-right-atrium
#16
Moe Kodama, Maiko Honma, Keisuke Shibukawa, Yasuhiro Kamada, Shoji Yanagiya, Michiaki Yamakage
Intravenous leiomyomatosis (IVL) is a condition in which leiomyoma originating from uterine myoma or intrauterine venous walls develops intravenously. A single-stage operation was planned by the departments of gynecology and cardiovascular surgery for a patient in which the IVL was extended across the tricuspid valve. It was possible to safely perform perioperative care with continued evaluation of the tumor position and intravascular volume through the use of transesophageal echocardiography (TEE). TEE can be useful in the intraoperative care of patients with intracardiac tumor extension as in this case...
May 2017: Masui. the Japanese Journal of Anesthesiology
https://www.readbyqxmd.com/read/29693017/prevention-and-management-of-complications-in-laparoscopic-myomectomy
#17
REVIEW
V Tanos, K E Berry, M Frist, R Campo, R L DeWilde
Myomectomy aims to preserve fertility, treat abnormal uterine bleeding, and alleviate pain. It should cause minimal damage to the endometrium, while being tolerable and durable, and reduce the incidence of myoma recurrence and complications including bleeding, hematoma, adhesions, and gravid uterus perforation. Training and experience are crucial to reduce complications. The surgical strategy depends on imaging information on the myomas. The position of the optical and secondary ports will determine the degree of ergonomic surgery performance, time and difficulty of myoma enucleation, and the suturing quality...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29673678/uterine-rupture-at-33rd-week-of-gestation-after-laparoscopic-myomectomy-with-signs-of-fetal-distress-a-case-report-and-review-of-literature
#18
Hiroyuki Yazawa, Kaoru Takiguchi, Fumihiro Ito, Keiya Fujimori
OBJECTIVE: We describe a case of uterine rupture (UR) during pregnancy after laparoscopic myomectomy (LM) and discuss the risk factors of UR. CASE REPORT: A 37-year-old woman with multiple myomas underwent laparoscopic myomectomy. Subserosal and intramural myomas were enucleated, and the myometrial wounds were repaired with single-layer suturing. Sixteen months after the operation, the patient conceived. At 33 weeks of gestation, emergency cesarean section was performed for the indication of fetal distress...
April 2018: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29673671/a-case-control-study-to-compare-the-outcome-of-women-treated-by-two-minimally-invasive-procedures-ultraminilaparotomy-myomectomy-and-laparoscopic-myomectomy
#19
Kuo-Chang Wen, Pi-Lin Sung, Wen-Hsun Chang, Huann-Cheng Horng, Yi-Jen Chen, Wen-Ling Lee, Peng-Hui Wang
OBJECTIVE: Ultraminilaparotomy myomectomy (UMLT-M with less 4 cm transverse skin incision) and conventional 3-port wound laparoscopic myomectomy (LM) approaches were proposed as alternative minimally invasive procedures in the management of women with symptomatic uterine myomas but few studies have compared the outcomes of both procedures. MATERIALS AND METHODS: Between January 2002 and December 2003, 71 patients undergoing UMLT-M were compared with those 71 women undergoing LM...
April 2018: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29643632/venous-gas-embolism-in-operative-hysteroscopy-a-devastating-complication-in-a-relatively-simple-surgery
#20
Amit Verma, Madhu Pandey Singh
Venous air embolism can be a catastrophic iatrogenic complication during operative hysteroscopy and makes this simple surgical procedure very risky, especially with the lack of knowledge about its prevention, presentation, and immediate management. Three out of 13 hysteroscopic myoma resections at our center had venous gas embolism (VGE). The prevention, diagnosis, and management of VGE are described in this report of three cases.
January 2018: Journal of Anaesthesiology, Clinical Pharmacology
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