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https://www.readbyqxmd.com/read/29238287/survey-among-esge-members-on-leiomyosarcoma-morcellation-incidence
#1
Vasilios Tanos, Hans Brölmann, Rudi Leon DeWilde, Peter O'Donovan, Elina Symeonidou, Rudi Campo
Background: Increased awareness of leiomyosarcoma (LMS) risk during myomectomy or hysterectomy is essential. Objective and correct reasoning should prevail on any decision regarding the extent and type of surgery to employ. The anticipated risk of a sarcoma after myoma or uterus morcellation is low, and the frequency of leiomyosarcoma especially in women below the age of 40 is very rare. The prevalence data has a wide range and is therefore not reliable. The European Society of Gynaecological Endoscopy (ESGE) initiated a survey among its members looking into the frequency of morcellated leiomyosarcoma after endoscopic surgery...
2017: Gynecological Surgery
https://www.readbyqxmd.com/read/29236171/uterine%C3%A2-fibroid-size-modifications-during-pregnancy-and-puerperium-evidence-from-the-first-systematic-review-of-literature
#2
REVIEW
Amerigo Vitagliano, Marco Noventa, Attilio Di Spiezio Sardo, Gabriele Saccone, Salvatore Gizzo, Shara Borgato, Salvatore Giovannni Vitale, Antonio Simone Laganà, Giovanni Battista Nardelli, Pietro Salvatore Litta, Carlo Saccardi
PURPOSE: The influence of pregnancy on uterine fibroid size still remains an unsolved dilemma. Basing on current knowledge, physicians are not able to inform patients about the likelihood of uterine fibroids to modify their size during pregnancy. Study aim was to summarize available evidence concerning the size modifications of uterine fibroids during each trimester of pregnancy and during puerperium. METHODS: The review was reported following the PRISMA guidelines and registered in PROSPERO (registration number: CRD42017071117)...
December 13, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29234680/myomas-and-adenomyosis-impact-on-reproductive-outcome
#3
REVIEW
Nikos F Vlahos, Theodoros D Theodoridis, George A Partsinevelos
Among uterine structural abnormalities, myomas and adenomyosis represent two distinct, though frequently coexistent entities, with a remarkable prevalence in women of reproductive age. Various mechanisms have been proposed to explain the impact of each of them on reproductive outcome. In respect to myomas, current evidence implies that submucosal ones have an adverse effect on conception and early pregnancy. A similar effect yet is not quite clear and has been suggested for intramural myomas. Still, it seems reasonable that intramural myomas greater than 4 cm in diameter may negatively impair reproductive outcome...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29227976/progesterone-receptor-isoforms-nuclear-corepressor-1-and-steroid-receptor-coactivator-1-and-b-cell-lymphoma-2-and-akt-and-akt-phosphorylation-status-in-uterine-myomas-after-ulipristal-acetate-treatment-a-systematic-immunohistochemical-evaluation
#4
Guillaume E Courtoy, Jacques Donnez, Etienne Marbaix, Matilde Barreira, Mathieu Luyckx, Marie-Madeleine Dolmans
OBJECTIVE: To investigate whether ulipristal acetate (UPA) treatment modifies the expression of progesterone receptor (PR), its nuclear cofactors steroid receptor coactivator-1 (SRC1) and nuclear corepressor-1 (NCoR1), prosurvival factor B-cell lymphoma 2 (Bcl-2), and Akt in uterine myomas. PATIENTS: Prospective study of 59 women with symptomatic myomas undergoing myomectomy. Forty-two patients were treated preoperatively with UPA; the remaining 17 were not and they served as controls...
December 11, 2017: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/29227848/development-and-evaluation-of-an-improved-laparoscopic-myomectomy-adopting-intracapsular-rotary-cut-procedures
#5
Shi-Lin Zhong, Li-Ping Zeng, Huan Li, Rui-Fang Wu
OBJECTIVES: To develop and evaluate the efficacy and feasibility of Intracapsular Rotary-cut Procedure (IRCP) in laparoscopic myomectomy (LM). STUDY DESIGN: It is a retrospective study conducted in Peking University Shenzhen Hospital (PUSH) in Shenzhen, China. A total of 96 patients who were treated with LM because of big and moderate size of myomas in PUSH from January 2013 and December 2015 were enrolled in this study. Among them 35 were managed with IRCP -integrated LM as the study group, while the other 61 were treated with normal LM as the control group...
November 27, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29227004/recurrence-of-uterine-myoma-after-myomectomy-open-myomectomy-versus-laparoscopic-myomectomy
#6
Yasushi Kotani, Takako Tobiume, Risa Fujishima, Mamoru Shigeta, Hisamitsu Takaya, Hidekatsu Nakai, Ayako Suzuki, Isao Tsuji, Masaki Mandai, Noriomi Matsumura
AIM: Open myomectomy (OM) was previously frequently performed; however, laparoscopic myomectomy (LM) has recently become more common. Nevertheless, myoma can recur after both LM and OM. In this study, we report our retrospective investigation of myoma recurrence by comparing LM and OM. METHODS: A total of 474 patients underwent LM and 279 patients underwent OM. The patients were followed-up postoperatively from six months to eight years. Recurrence was confirmed when a myoma with a diameter of ≥ 1 cm was detected...
December 11, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/29221993/accuracy-of-tubal-patency-assessment-in-diagnostic-hysteroscopy-compared-to-laparoscopy-in-infertile-women-a-retrospective-cohort-study
#7
Regina Promberger, Inga-Malin Simek, Kazem Nouri, Karin Obermaier, Christine Kurz, Johannes Ott
STUDY OBJECTIVE: To evaluate whether the presence of a visualizable "flow" effect in the Fallopian tube ostia in hysteroscopic routine evaluation is predictive of tube patency. DESIGN: Retrospective cohort study (Canadian Task Force Classification II-2) SETTING: Data from all patients who underwent surgery due to infertility at the study center between 2008 and 2016 was analyzed retrospectively. The main outcome parameter was Fallopian tube patency as assessed by laparoscopic chromopertubation...
December 5, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29215821/a-fast-3-dimensional-magnetic-resonance-imaging-reconstruction-for-surgical-planning-of-uterine-myomectomy
#8
Sa Ra Lee, Young Jae Kim, Kwang Gi Kim
BACKGROUND: Uterine myoma is the most common benign gynecologic tumor in reproductive-aged women. During myomectomy for women who want to preserve fertility, it is advisable to detect and remove all myomas to decrease the risk of additional surgery. However, finding myomas during surgery is often challenging, especially for deep-seated myomas. Therefore, three-dimensional (3D) preoperative localization of myomas can be helpful for the surgical planning for myomectomy. However, the previously reported manual 3D segmenting method takes too much time and effort for clinical use...
January 8, 2018: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/29200476/outcome-of-cesarean-myomectomy-is-it-a-safe-procedure
#9
Mehmet Baki Senturk, Mesut Polat, Ozan Doğan, Çiğdem Pulatoğlu, Oğuz Devrim Yardımcı, Resul Karakuş, Ahter Tanay Tayyar
Objective: Myomectomy performed during cesarean section is still controversial because of the potential for associated complications, especially with large myomas. Many obstetricians avoid performing cesarean myomectomy procedures because of the risk of uncontrollable hemorrhage. However, the prevalence of pregnant women with myomas is increasing, leading to an increase in the likelihood that physicians will encounter this issue. The aim of this study was to compare outcomes and complications of patients who either had or did not have cesarean myomectomy...
November 2017: Geburtshilfe und Frauenheilkunde
https://www.readbyqxmd.com/read/29199806/selective-progesterone-receptor-modulators-new-possibilities-for-gynecologic-hormone-therapy
#10
Nanna Sarvilinna, Leila Unkila-Kallio, Päivi Härkki, Aila Tiitinen, Oskari Heikinheimo
Progesterone regulates several female reproductive functions. Progesterone and synthetic progestins derived from it have long been utilized in gynecology. The effects of these steroids in target cells are mediated via progesterone receptors, Progesterone receptors are also the target of action of selective progesterone receptor modulators. Of the molecules of this newer group of drugs, two are presently in clinical use. Mifepristone is used in nonsurgical abortion, in softening of the cervix before surgical abortion, and in the induction of labor in cases of intrauterine death...
2017: Duodecim; Lääketieteellinen Aikakauskirja
https://www.readbyqxmd.com/read/29198424/the-uterine-fibroid-myoma-tumour-analysis-of-the-global-research-architecture-using-density-equalizing-mapping
#11
Dörthe Brüggmann, Frank Louwen, Tatjana Braun, Doris Klingelhöfer, Jan Bauer, Michael H Bendels, Matthias Bundschuh, David Quarcoo, Jenny Jaque, Eileen M Wanke, David A Groneberg
Uterine fibroids can severely impact a woman's quality of life, result in significant morbidity and are a leading indication for hysterectomy. Many aspects of the disease remain largely obscure. Despite these knowledge gaps, no detailed maps of the global fibroid research architecture have yet been generated. This study used the NewQIS approach to assess worldwide research productivity, encompassing numerous aspects of the scientific output, quality and socioeconomic features. Regression analysis indicated an increase in fibroid research activity in the investigated time periods...
November 15, 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/29196156/leiomyomatosis-peritonealisis-disseminata-two-unusual-cases-with-literature-review
#12
L Gaichies, L Fabre-Monplaisir, R Fauvet, A Alves, A Mulliri
BACKGROUND: Leiomyomatosis peritonealis disseminata (LPD) is a rare benign disease characterized by numerous smooth muscle-like cell nodules disseminated among the abdominal cavity. The pathogenesis of LPD is not well known; one hypothesis, widely reported, is parasitic LPD (after uterine myoma surgery). The role of hormonal status has been raised without any evidence yet confirmed. Lesions of LPD can mimic carcinomatosis and lead to an unappropriated treatment. Total and spontaneous regression of the nodules is sometimes reported...
November 28, 2017: Journal of Gynecology Obstetrics and Human Reproduction
https://www.readbyqxmd.com/read/29186429/extracellular-matrix-in-uterine-leiomyoma-pathogenesis-a-potential-target-for-future-therapeutics
#13
Md Soriful Islam, Andrea Ciavattini, Felice Petraglia, Mario Castellucci, Pasquapina Ciarmela
BACKGROUND: Uterine leiomyoma (also known as fibroid or myoma) is the most common benign tumor of the uterus found in women of reproductive age. It is not usually fatal but can produce serious clinical symptoms, including excessive uterine bleeding, pelvic pain or pressure, infertility and pregnancy complications. Due to lack of effective medical treatments surgery has been a definitive choice for the management of this tumor. OBJECTIVE AND RATIONALE: Extracellular matrix (ECM) accumulation and remodeling are thought to be crucial for fibrotic diseases such as uterine leiomyoma...
November 23, 2017: Human Reproduction Update
https://www.readbyqxmd.com/read/29184870/a-retroperitoneal-dedifferentiated-liposarcoma-mimicking-an-ovarian-tumor
#14
Hyojin Kim, Taewon Jeong, Yeongho Lee, Gyeonga Kim, Sanggi Hong, Sukyung Beck, Jeongbeom Mun, Kyongjin Kim, Myeongjin Ju
A 74-year-old postmenopausal woman visited our gynecology clinic complaining of a palpable abdominal mass. Physical and radiological evaluation indicated that the mass exhibited features of a left ovarian neoplasm showing heterogeneous enhancement. Surgical resection was performed to confirm this suspicion. During surgery, a mass was observed only in the left ovary with no invasive growth, but adhesions to the surrounding peritoneum were seen. Given the patient's age, large mass size, and accompanying uterine myoma and right ovarian cyst, total abdominal hysterectomy with bilateral salpingo-oophorectomy was performed...
November 2017: Obstetrics & Gynecology Science
https://www.readbyqxmd.com/read/29180306/the-intraoperative-effect-of-preoperative-gnrh-analogue-administration-in-women-undergoing-cold-loop-hysteroscopic-myomectomy-a-randomized-controlled-trial
#15
Alessandro Favilli, Ivan Mazzon, Mario Grasso, Stefano Horvath, Vittorio Bini, Gian Carlo Di Renzo, Sandro Gerli
STUDY OBJECTIVE: To evaluate the intraoperative effects of GnRH analogue pretreatment in patients undergoing cold loop hysteroscopic myomectomy. DESIGN: Randomized controlled trial (Canadian Task Force Classification I). SETTING: Arbor Vitae Center for Endoscopic Gynecology, Rome, Italy. PATIENTS: A total of 99 patients were randomized and subsequently allocated to the GnRH analogue group and to the non-pharmacological treatment control group...
November 24, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29179628/pregnancy-after-uterine-artery-embolization-using-gelfoam%C3%A2
#16
Katherine Jane C Chua, Bruce McLucas
We present a case study of a patient who underwent uterine artery embolization (UAE) using Gelfoam™ (Pfizer, New York, NY, USA) and had a subsequent pregnancy. Our patient, a 38-year-old female (4 Gravida/2 Para), underwent UAE for treatment of symptomatic myoma in September 2005. At the patient's seven-month post procedure visit, she experienced a 43.9% volume reduction in uterine size and 74.5% reduction in volume of the largest fibroid and relief of bulk symptoms and menorrhagia. The patient had a term delivery of healthy twin infants 15 months post embolization...
November 27, 2017: Minimally Invasive Therapy & Allied Technologies: MITAT
https://www.readbyqxmd.com/read/29176884/alcohol-consumption-and-risk-of-uterine-myoma-a-systematic-review-and-meta-analysis
#17
Francesca Chiaffarino, Sonia Cipriani, Elena Ricci, Carlo La Vecchia, Vito Chiantera, Alessandro Bulfoni, Fabio Parazzini
BACKGROUND: The published data about alcohol consumption and uterine myoma are scanty and controversial: some studies found positive association whereas other studies showed no association. OBJECTIVES: To conduct a systematic review and meta-analysis to determine whether alcohol is a risk factor for myoma. SEARCH STRATEGY: A MEDLINE/EMBASE search was carried out, supplemented by manual searches of bibliographies of the selected studies. SELECTION CRITERIA: Articles published as full-length papers in English...
2017: PloS One
https://www.readbyqxmd.com/read/29169896/the-current-place-of-medical-therapy-in-uterine-fibroid-management
#18
REVIEW
Jacques Donnez, Olivier Donnez, Marie-Madeleine Dolmans
Uterine fibroids (also known as leiomyomas or myomas) are the most common form of benign uterine tumors. Current management strategies mainly involve surgical interventions, but the choice of treatment is guided by patient's age and desire to preserve fertility or avoid "radical" surgery. Surgical and non-surgical approaches include hysterectomy myomectomy by hysteroscopy, myomectomy by laparotomy or laparoscopy, uterine artery embolization, and magnetic resonance-guided focused ultrasound surgery. The need for alternatives to surgical intervention is very real, especially for women seeking to preserve their fertility...
October 22, 2017: Best Practice & Research. Clinical Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/29158312/organotypic-three-dimensional-assays-based-on-human-leiomyoma-derived-matrices
#19
REVIEW
Tuula Salo, Mauricio Rocha Dourado, Elias Sundquist, Ehsanul Hoque Apu, Ilkka Alahuhta, Katja Tuomainen, Jenni Vasara, Ahmed Al-Samadi
Alongside cancer cells, tumours exhibit a complex stroma containing a repertoire of cells, matrix molecules and soluble factors that actively crosstalk between each other. Recognition of this multifaceted concept of the tumour microenvironment (TME) calls for authentic TME mimetics to study cancer in vitro Traditionally, tumourigenesis has been investigated in non-human, three-dimensional rat type I collagen containing organotypic discs or by means of mouse sarcoma-derived gel, such as Matrigel(®) However, the molecular compositions of these simplified assays do not properly simulate human TME...
January 5, 2018: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/29148636/outcome-of-pregnancy-with-clinically-visible-palpable-myoma-among-women-who-undergo-caesarian-section-in-three-teaching-hospitals-addis-ababa-ethiopia-a-cross-sectional-study
#20
Getu Dinku, Eyasu Mesfin
Introduction: Myoma is the most common pelvic tumor and an enormous healthcare concern in women. Complications occur in approximately 10-40% of pregnancies with myomatous uterus. This study is conducted to determine the prevalence and obstetric outcome of grossly visible and/or palpable myoma among women who gave birth by caesarean section. Methods: A cross sectional study conducted in three teaching hospitals in Addis Ababa, Ethiopia. Data was collected using a pre-tested questioner...
January 2017: Ethiopian Medical Journal
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