keyword
https://read.qxmd.com/read/38479928/effect-of-multicomponent-intervention-on-malnutrition-in-older-adults-a-multicenter-randomized-clinical-trial
#21
RANDOMIZED CONTROLLED TRIAL
Bo Chen, Hongye Zhao, Min Li, Ting Zhao, Ruoqi Liao, Jun Lu, Yanzheng Zou, Junlan Tu, Xinran Teng, Yaxuan Huang, Jin Liu, Peng Huang, Jianqing Wu
BACKGROUND & AIMS: Malnutrition is a significant geriatric syndrome (GS) prevalent in older adults and seriously affects patient prognosis and quality of life. We assessed the impact of the multicomponent intervention of health education, dietary advice, and exercise with oral nutritional supplementation (ONS) on nutritional status, body composition, physical functions, and quality of life. METHODS: This multicenter randomized clinical trial (RCT) was performed from April 2021 to April 2022...
April 2024: Clinical Nutrition ESPEN
https://read.qxmd.com/read/38477858/prevalence-trends-and-characteristics-of-metabolic-dysfunction-associated-steatotic-liver-disease-among-the-us-population-aged-12-79-years
#22
JOURNAL ARTICLE
Tsung-Hua Shen, Chung-Hsuen Wu, Yuan-Wen Lee, Chun-Chao Chang
BACKGROUND AND AIMS: Clinical observation revealed an increase in metabolic dysfunction-associated steatotic liver disease (MASLD) prevalence among adults and adolescents and young adults (AYA). However, its prevalence trend in specific subgroups and its characteristics are unclear. APPROACH AND RESULTS: This cross-sectional study included adults and AYA aged 20-79 and 12-19 years, respectively, from the National Health and Nutrition Examination Survey from 1999 to 2018...
March 11, 2024: European Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/38477364/shear-wave-elastography-for-monitoring-fontan-associated-liver-disease-a-prospective-cohort-study
#23
JOURNAL ARTICLE
Rishi Bolia, Sara Alremawi, Charlton Noble, Robert Justo, Cameron Ward, Peter J Lewindon
The spectrum of Fontan-associated liver disease (FALD) varies from abnormal liver function tests to fibrosis and even cirrhosis. In this prospective study, we evaluated the role of shear-wave elastography (SWE) in predicting the presence of advanced FALD. Forty-eight patients (30 males, 13.9 [6-21] years) with a Fontan circulation were evaluated at 8.3 (2.1-18.7) years since the Fontan surgery. The median liver stiffness measurement (LSM) value was higher than values in normal children at 15.4 (9.5-38.7) kPa...
March 13, 2024: Journal of Pediatric Gastroenterology and Nutrition
https://read.qxmd.com/read/38475999/effects-of-silymarin-supplementation-on-liver-and-kidney-functions-a-systematic-review-and-dose-response-meta-analysis
#24
REVIEW
Shooka Mohammadi, Damoon Ashtary-Larky, Omid Asbaghi, Vida Farrokhi, Yasaman Jadidi, Fatemeh Mofidi, Mehrnaz Mohammadian, Reza Afrisham
It is suggested that supplementation with silymarin (SIL) has beneficial impacts on kidney and liver functions. This systematic review and dose-response meta-analysis assessed the impact of SIL administration on certain hepatic, renal, and oxidative stress markers. A systematic search was conducted in various databases to identify relevant trials published until January 2023. Randomized controlled trials (RCTs) that evaluated the effects of SIL on kidney and liver markers were included. A random-effects model was used for the analysis and 41 RCTs were included...
March 12, 2024: Phytotherapy Research: PTR
https://read.qxmd.com/read/38475825/cryopreserved-cgmp-compliant-human-pluripotent-stem-cell-derived-hepatic-progenitors-rescue-mice-from-acute-liver-failure-through-rapid-paracrine-effects-on-liver-cells
#25
JOURNAL ARTICLE
Malika Gantier, Raphaël Rispal, Angélique Fourrier, Séverine Ménoret, Frédéric Delbos, Ignacio Anegon, Tuan Huy Nguyen
BACKGROUND: Liver transplantation remains the only curative treatment for end-stage liver diseases. Unfortunately, there is a drastic organ donor shortage. Hepatocyte transplantation emerged as a viable alternative to liver transplantation. Considering their unique expansion capabilities and their potency to be driven toward a chosen cell fate, pluripotent stem cells are extensively studied as an unlimited cell source of hepatocytes for cell therapy. It has been previously shown that freshly prepared hepatocyte-like cells can cure mice from acute and chronic liver failure and restore liver function...
March 12, 2024: Stem Cell Research & Therapy
https://read.qxmd.com/read/38473907/intersecting-pathways-nonalcoholic-fatty-liver-disease-and-psoriasis-duet-a-comprehensive-review
#26
REVIEW
Daniel Octavian Costache, Horia Blejan, Damian Lucian Cojocaru, Georgiana Alexandra Ioniță, Marcela Poenaru, Maria Magdalena Constantin, Andrei Cătălin Costache, Constantin Căruntu, Daniel Vasile Balaban, Raluca Simona Costache
Psoriasis is a chronic, immune-mediated, inflammatory disease that has a major impact on patients' quality of life. Common psoriasis-associated comorbidities include cardiovascular diseases, psoriatic arthritis, inflammatory bowel syndromes, type-2 diabetes, and metabolic syndrome. Nonalcoholic fatty liver disease (NAFLD) is affecting a substantial portion of the population and is closely linked with psoriasis. The interplay involves low-grade chronic inflammation, insulin resistance, and genetic factors. The review presents the pathophysiological connections between psoriasis and nonalcoholic fatty liver disease, emphasizing the role of cytokines, adipokines, and inflammatory cascades...
February 24, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38473052/a-polyherbal-mixture-with-nutraceutical-properties-for-ruminants-a-meta-analysis-and-review-of-biocholine-powder
#27
REVIEW
Germán David Mendoza-Martínez, José Felipe Orzuna-Orzuna, José Alejandro Roque-Jiménez, Adrián Gloria-Trujillo, José Antonio Martínez-García, Nallely Sánchez-López, Pedro Abel Hernández-García, Héctor Aaron Lee-Rangel
BioCholine Powder is a polyherbal feed additive composed of Achyrantes aspera , Trachyspermum ammi , Azadirachta indica , and Citrullus colocynthis . The objective of this study was to analyze published results that support the hypothesis that the polyherbal product BioCholine Powder has rumen bypass choline metabolites through a meta-analysis and effect size analysis (ES). Using Scopus, Web of Science, ScienceDirect, PubMed, and university dissertation databases, a systematic search was conducted for experiments published in scientific documents that evaluated the effects of BioCholine supplementation on the variables of interest...
February 20, 2024: Animals: An Open Access Journal From MDPI
https://read.qxmd.com/read/38472929/noninvasive-models-to-assess-liver-inflammation-and-fibrosis-in-chronic-hbv-infected-patients-with-normal-or-mildly-elevated-alanine-transaminase-levels-which-one-is-most-suitable
#28
JOURNAL ARTICLE
Shasha Ma, Lian Zhou, Shutao Lin, Mingna Li, Jing Luo, Lubiao Chen
The prevalence of substantial inflammation or fibrosis in treatment-naïve patients with chronic hepatitis B (CHB) and normal alanine transaminase (ALT) levels is high. A retrospective analysis was conducted on 559 consecutive patients with hepatitis B virus infection, who underwent liver biopsy, to investigate the value of noninvasive models based on routine serum markers for evaluating liver histology in CHB patients with normal or mildly elevated ALT levels and to provide treatment guidance. After comparing 55 models, we identified the top three models that exhibited excellent performance...
February 20, 2024: Diagnostics
https://read.qxmd.com/read/38472823/exploring-therapeutic-potential-of-pleurotus-ostreatus-and-agaricus-bisporus-mushrooms-against-hyperlipidemia-and-oxidative-stress-using-animal-model
#29
JOURNAL ARTICLE
Touseef Iqbal, Muhammad Sohaib, Sanaullah Iqbal, Habib Rehman
The mushrooms oyster ( Pleurotus ostreatus ) and white button ( Agaricus bisporus ) contain bioactive compounds that have potential beneficial effects on hypercholesterolemia and cardiovascular diseases. In this study, hypolipidemic and antioxidative potential of these mushrooms' extract were explored using hypercholesterolemic (HC) rats as animal model. For the study, 56 adult rats were divided into seven groups, i.e., G1 (negative control), G2 (positive control group), G3 (HC rats with statin drug orally), G4 and G5 (HC rats @ 100 and 200 mg/kg body weight (BW) dose of oyster mushroom extracts), and G6 and G7 (HC rats @ 100 and 200 mg/kg BW dose of white button mushroom extracts)...
February 26, 2024: Foods (Basel, Switzerland)
https://read.qxmd.com/read/38472759/optimization-of-microwave-assisted-extraction-process-of-total-flavonoids-from-salicornia-bigelovii-torr-and-its-hepatoprotective-effect-on-alcoholic-liver-injury-mice
#30
JOURNAL ARTICLE
Dujun Wang, Jing Lv, Yan Fu, Yueling Shang, Jinbin Liu, Yongmei Lyu, Ming Wei, Xiaohong Yu
The objective of this study was to determine the optimal extraction conditions for total flavonoids from S. bigelovii using microwave-assisted extraction and to analyze the protective effect of total flavonoids from S. bigelovii on alcoholic liver injury in mice. The optimization of the process conditions for the microwave-assisted extraction of total flavonoids from S. bigelovii was performed using response surface methodology, and an alcohol-induced acute liver injury model in mice was used to investigate the effects of different doses of total flavonoids (100 mg/kg, 200 mg/kg, and 400 mg/kg) on the levels and activities of serum alanine aminotransferase kits (ALT), glutamic oxaloacetic transaminase kits (AST), superoxide dismutase kits (SOD), glutathione peroxidase kits (GSH-Px), and malondialdehyde (MDA)...
February 21, 2024: Foods (Basel, Switzerland)
https://read.qxmd.com/read/38470022/the-integration-of-coxiella-burnetii-pcr-testing-in-serum-into-the-diagnostic-algorithm-of-suspected-acute-q-fever-in-an-endemic-setting
#31
JOURNAL ARTICLE
Nesrin Ghanem-Zoubi, Mona Mustafa-Hellou, Maram Zahran, Liat Gazit, Raya Shalaginov, Halima Dabaja-Younis, Moran Szwarcwort
UNLABELLED: Serum polymerase chain reaction (PCR) for the detection of Coxiella burnetii DNA has been suggested for rapid Q fever diagnosis. We evaluated the role of PCR testing in serum in the diagnosis of acute Q fever in an endemic setting. We examined patients suspected of acute Q fever tested for C. burnetii -specific serum real-time PCR in a tertiary hospital between January 2019 toand December 2022. In the first half, PCR orders were consultation-based by infectious diseases specialists, while in the second half, they were guided by serology, positive IgM2, and negative IgG1 and IgG2, indicating early acute infection...
March 12, 2024: Journal of Clinical Microbiology
https://read.qxmd.com/read/38469646/glycerol-phenylbutyrate-treatment-of-two-patients-with-monocarboxylate-transporter-8-deficiency
#32
JOURNAL ARTICLE
Amnon Zung, Niklas Sonntag, Ulrich Schweizer, Ehud Banne, Doreen Braun
CONTEXT: Monocarboxylate transporter 8 (MCT8) deficiency is a rare genetic disease that leads to severe global developmental delay. MCT8 facilitates thyroid hormone (TH) transport across the cell membrane, and the serum TH profile is characterized by high T3 and low T4 levels. Recent studies have shown that the chemical chaperone sodium phenylbutyrate (NaPB) restored mutant MCT8 function and increased TH content in patient-derived induced pluripotent stem cells, making it a potential treatment for MCT8 deficiency...
March 12, 2024: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/38469563/transcriptomic-signatures-of-progressive-and-regressive-liver-fibrosis-and-portal-hypertension
#33
JOURNAL ARTICLE
Oleksandr Petrenko, Philipp Königshofer, Ksenia Brusilovskaya, Benedikt S Hofer, Katharina Bareiner, Benedikt Simbrunner, Frank Jühling, Thomas F Baumert, Joachim Lupberger, Michael Trauner, Stefan G Kauschke, Larissa Pfisterer, Eric Simon, André F Rendeiro, Laura P M H de Rooij, Philipp Schwabl, Thomas Reiberger
Persistent liver injury triggers a fibrogenic program that causes pathologic remodeling of the hepatic microenvironment (i.e., liver fibrosis) and portal hypertension. The dynamics of gene regulation during liver disease progression and early regression remain understudied. Here, we generated hepatic transcriptome profiles in two well-established liver disease models at peak fibrosis and during spontaneous regression after the removal of the inducing agents. We linked the dynamics of key disease readouts, such as portal pressure, collagen area, and transaminase levels, to differentially expressed genes, enabling the identification of transcriptomic signatures of progressive vs...
March 15, 2024: IScience
https://read.qxmd.com/read/38469128/severe-dengue-infection-unmasking-drug-induced-liver-injury-successful-management-with-n-acetylcysteine
#34
Naveen Gautam, Nishan Shrestha, Sanjeev Bhandari, Sabin Thapaliya
KEY CLINICAL MESSAGE: Clinicians in tuberculosis and dengue endemic regions should have heightened vigilance for drug-induced liver injury (DILI) overlapping with active infections, enabling prompt recognition and life-saving conservative management. ABSTRACT: Severe dengue and drug-induced liver injury (DILI) are significant independent risk factors for acute liver failure. The co-occurrence of these conditions significantly complicates clinical management. Here, we describe the case of a 21-year-old Nepali female who developed acute liver failure during antitubercular therapy (ATT)...
March 2024: Clinical Case Reports
https://read.qxmd.com/read/38467670/point-of-care-lung-ultrasound-predicts-hyperferritinemia-and-hospitalization-but-not-elevated-troponin-in-sars-cov-2-viral-pneumonitis-in-children
#35
JOURNAL ARTICLE
Paul Walsh, Andrea Hankins, Heejung Bang
SARS-CoV-2 often causes viral pneumonitis, hyperferritinemia, elevations in D-dimer, lactate dehydrogenase (LDH), transaminases, troponin, CRP, and other inflammatory markers. Lung ultrasound is increasingly used to diagnose and stratify viral pneumonitis severity. We retrospectively reviewed 427 visits in patients aged 14 days to 21 years who had had a point-of-care lung ultrasound in our pediatric emergency department from 30/November/2019 to 14/August/2021. Lung ultrasounds were categorized using a 6-point ordinal scale...
March 11, 2024: Scientific Reports
https://read.qxmd.com/read/38467320/rujifang-inhibits-triple-negative-breast-cancer-growth-via-the-pi3k-akt-pathway
#36
JOURNAL ARTICLE
Wenyu Jia, Xuan Lin, Xuezhang Chen, Hongliang Li, Xingru Zhang, Yuzhuo Zhang, Yinsong Chen, Bin Wang, Xikang Chen, Ju Chen, Huaqin Tian
ETHNOPHARMACOLOGICAL RELEVANCE: Rujifang (RJF) constitutes a traditional Chinese medicinal compound extensively employed in the management of triple-negative breast cancer (TNBC). However, information regarding its potential active ingredients, antitumor effects, safety, and mechanism of action remains unreported. AIM OF THE STUDY: To investigate the efficacy and safety of RJF in the context of TNBC. MATERIALS AND METHODS: We employed the ultra high-performance liquid chromatography-electrospray four-pole time-of-flight mass spectrometry technique (UPLC/Q-TOF-MS/MS) to scrutinize the chemical constituents of RJF...
March 9, 2024: Journal of Ethnopharmacology
https://read.qxmd.com/read/38466881/berberine-alleviates-concanavalin-a-induced-autoimmune-hepatitis-in-mice-by-modulating-the-gut-microbiota
#37
JOURNAL ARTICLE
Hao Yang, Qingqing Liu, Haixia Liu, Xing Kang, Haixia Tian, Yongbo Kang, Lin Li, Xiaodan Yang, Peng Ren, Xiaoyu Kuang, Xiaohui Wang, Linzhi Guo, Mingwei Tong, Jieqiong Ma, Weiping Fan
BACKGROUND: Autoimmune hepatitis (AIH) is an immune-mediated liver disease of unknown etiology accompanied by intestinal dysbiosis and a damaged intestinal barrier. Berberine (BBR) is a traditional antibacterial medicine that has a variety of pharmacological properties. It has been reported that BBR alleviates AIH, but relevant mechanisms remain to be fully explored. METHODS: BBR was orally administered at doses of 100 mg⋅kg-1⋅d-1 for 7 days to mice before concanavalin A-induced AIH model establishment...
April 1, 2024: Hepatology Communications
https://read.qxmd.com/read/38465663/persistent-fever-in-acute-hepatitis-think-beyond-acute-viral-hepatitis
#38
JOURNAL ARTICLE
Arghya Samanta, Ujjal Poddar, Moinak Sen Sarma, Anshu Srivastava, Surender Kumar Yachha, Prabhakar Mishra
BACKGROUND: Acute hepatitis due to various tropical infections can mimic the clinical picture of acute viral hepatitis(AVH), leading to increased morbidity and mortality. We aimed to identify clinical and laboratory parameters that could help to distinguish acute hepatitis due to tropical infections from AVH. METHODS: We retrospectively analyzed our database of 150 children (107 boys) with AVH and 50 children(34 boys)with acute hepatitis due to tropical infections between January 2013 and March 2023...
March 11, 2024: Infectious Diseases
https://read.qxmd.com/read/38464895/subcutaneous-anakinra-in-the-management-of-refractory-mis-c-in-france
#39
JOURNAL ARTICLE
Perrine Dusser, Alexandre Belot, Fanny Bajolle, Charlotte Kevorkian-Verguet, Ulrich Meinzer, Frédéric Huet, Soizic Tiriau, Isabelle Kone-Paut
INTRODUCTION: Multisystemic inflammatory syndrome in children (MIS-C) is a therapeutic emergency and can lead to myocardial dysfunction (17%-75%) and heart failure (52%-53%). Intravenous immunoglobulins (IVIG) and corticosteroids (CST) have been validated for the management of this condition. Recent reports suggest that an interleukin-1 (IL-1) receptor antagonist, namely anakinra, may be a valuable add-on to the 2019 novel coronavirus disease (COVID-19) treatment for refractory patients...
2024: Frontiers in Pediatrics
https://read.qxmd.com/read/38463371/efficacy-of-transjugular-intrahepatic-portosystemic-shunts-in-treating-cirrhotic-esophageal-gastric-variceal-bleeding
#40
JOURNAL ARTICLE
Xiao-Gang Hu, Jian-Ji Dai, Jun Lu, Gang Li, Jia-Min Wang, Yi Deng, Rui Feng, Kai-Ping Lu
BACKGROUND: Esophageal-gastric variceal bleeding (EGVB) represents a severe complication among patients with cirrhosis and often culminates in fatal outcomes. Interventional therapy, a rapidly developing treatment modality over the past few years, has found widespread application in clinical practice due to its minimally invasive characteristics. However, whether transjugular intrahepatic portosystemic shunt (TIPS) treatment has an impact on patient prognosis remains controversial. AIM: To probing the efficacy of TIPS for treating cirrhotic EGVB and its influence on the prognosis of patients afflicted by this disease...
February 27, 2024: World Journal of Gastrointestinal Surgery
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