Oleksandr Petrenko, Philipp Königshofer, Ksenia Brusilovskaya, Benedikt S Hofer, Katharina Bareiner, Benedikt Simbrunner, Frank Jühling, Thomas F Baumert, Joachim Lupberger, Michael Trauner, Stefan G Kauschke, Larissa Pfisterer, Eric Simon, André F Rendeiro, Laura P M H de Rooij, Philipp Schwabl, Thomas Reiberger
Persistent liver injury triggers a fibrogenic program that causes pathologic remodeling of the hepatic microenvironment (i.e., liver fibrosis) and portal hypertension. The dynamics of gene regulation during liver disease progression and early regression remain understudied. Here, we generated hepatic transcriptome profiles in two well-established liver disease models at peak fibrosis and during spontaneous regression after the removal of the inducing agents. We linked the dynamics of key disease readouts, such as portal pressure, collagen area, and transaminase levels, to differentially expressed genes, enabling the identification of transcriptomic signatures of progressive vs...
March 15, 2024: IScience