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Moyamoya disease

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https://www.readbyqxmd.com/read/29030229/elevation-of-proenkephalin-143-183-in-cerebrospinal-fluid-in-moyamoya-disease
#1
Kinya Yokoyama, Mikio Maruwaka, Kazuhiro Yoshikawa, Yoshio Araki, Sho Okamoto, Masaki Sumitomo, Akino Kawamura, Yusuke Sakamoto, Kenzo Shimizu, Takashi Izumi, Toshihiko Wakabayashi
BACKGROUND: In moyamoya disease (MMD), the causes of differences in clinical features between children and adults and of the dramatic temporal changes in moyamoya vessels are poorly understood. We previously discovered elevated levels of m/z 4588 and m/z 4473 peptides in cerebrospinal fluid (CSF) in MMD patients. This study examined the amino acid sequences of these peptides and quantified in specimens. METHODS: The m/z 4588 and m/z 4473 peptides in CSF from MMD patients were purified and concentrated by high-performance liquid chromatography and ultrafiltration...
October 10, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29028653/adams-oliver-syndrome-with-moyamoya-disease-for-cerebral-revascularisation-surgery
#2
(no author information available yet)
No abstract text is available yet for this article.
October 12, 2017: Journal of Neurosurgical Anesthesiology
https://www.readbyqxmd.com/read/28991692/altered-expression-of-circular-rnas-in-moyamoya-disease
#3
Meng Zhao, Faliang Gao, Dong Zhang, Shuo Wang, Yan Zhang, Rong Wang, Jizong Zhao
Moyamoya disease (MMD) is the most common pediatric cerebrovascular disease in Eastern Asian countries but the etiology is not well understood. Circular RNAs (circRNAs) have been implicated in various biological processes, but their role in the development of MMD remains unclear. To address this issue, we carried out a comparative circRNA microarray analysis of blood samples obtained from patients with MMD and healthy subjects and identified 146 circRNAs that were differentially expressed between the two groups...
October 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28989169/moyamoya-disease-in-an-18-month-old-female-caucasian-complicated-by-cerebral-hyperperfusion-syndrome-following-indirect-revascularization
#4
James Murchison, John M Wilson, Coby Ray, Jessica Ginsberg, Laszlo Nagy
BACKGROUND Cerebral hyperperfusion syndrome is a rare complication of indirect revascularization due to moyamoya disease, but has not been reported previously in the pediatric population. We present a case of an 18-month-old girl with moyamoya disease that was treated with bilateral pial synangiosis and had complications consistent with cerebral hyperperfusion syndrome. This case report discusses the pathophysiological mechanisms involved in cerebral hyperperfusion in moyamoya syndrome. CASE REPORT An 18-month-old female Caucasian presented with seizures and weakness of the left side...
October 9, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/28987832/postoperative-cerebral-ischemia-due-to-hypotension-in-a-moyamoya-patient-with-autonomic-dysfunction-a-case-report
#5
Toshio Machida, Yoshinori Higuchi, Shigeki Nakano, Satoshi Ishige, Junichiro Shimada, Koichi Honma
BACKGROUND: Hypotension is a significant risk factor for the development of ischemic complication following revascularization surgery for moyamoya disease (MMD). However, it is currently unknown whether autonomic dysfunction also plays a role. CASE DESCRIPTION: Here we report a case of MMD in which hypotension due to autonomic dysfunction caused postoperative cerebral ischemia. A 30-year-old female patient with MMD had a history of transient right hemiparesis following laughter...
October 4, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28982784/clinical-and-imaging-characteristics-of-arteriopathy-subtypes-in-children-with-arterial-ischemic-stroke-results-of-the-vips-study
#6
M Wintermark, N K Hills, G A DeVeber, A J Barkovich, T J Bernard, N R Friedman, M T Mackay, A Kirton, G Zhu, C Leiva-Salinas, Q Hou, H J Fullerton
BACKGROUND AND PURPOSE: Childhood arteriopathies are rare but heterogenous, and difficult to diagnose and classify, especially by nonexperts. We quantified clinical and imaging characteristics associated with childhood arteriopathy subtypes to facilitate their diagnosis and classification in research and clinical settings. MATERIALS AND METHODS: The Vascular Effects of Infection in Pediatric Stroke (VIPS) study prospectively enrolled 355 children with arterial ischemic stroke (2010-2014)...
October 5, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28970816/direct-visualization-of-arterial-emboli-in-moyamoya-syndrome
#7
Julie G Shulman, Samuel Snider, Henri Vaitkevicius, Viken L Babikian, Nirav J Patel
BACKGROUND: Hemodynamic insufficiency is often considered the cause of ischemic stroke in patients with moyamoya syndrome. While high-intensity transient signals (HITS) on transcranial Doppler (TCD) have been reported in this population, the relationship between these signals and ischemic symptoms is not clearly established. Accordingly, current treatment is directed at improving perfusion. CLINICAL PRESENTATION: We present two patients with symptoms of cerebral ischemia and angiographic findings of moyamoya syndrome...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28968317/efficacy-of-surgery-in-the-treatment-of-moyamoya-disease-compared-with-medical-treatment
#8
Zengpanpan Ye, Xiaolin Ai, Chao You
No abstract text is available yet for this article.
September 29, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28967593/measurement-of-cerebrovascular-reactivity-as-blood-oxygen-level-dependent-magnetic-resonance-imaging-signal-response-to-a-hypercapnic-stimulus-in-mechanically-ventilated-patients
#9
Lashmi Venkatraghavan, Julien Poublanc, Jay S Han, Olivia Sobczyk, Casey Rozen, Kevin Sam, James Duffin, David J Mikulis, Joseph A Fisher
BACKGROUND: Impaired cerebrovascular reactivity (CVR) is an important prognostic marker of stroke. Most measures of CVR lack (1) a reproducible vasoactive stimulus and (2) a high time and spatial resolution measure of cerebral blood flow (CBF), particularly for mechanically ventilated patients. The aim of our study was to investigate the feasibility of measuring CVR using sequential gas delivery circuit and gas blender for precise targeting of end-tidal PCO2 (PetCO2), and blood oxygen level-dependent magnetic resonance imaging (BOLD-MRI) signal as a surrogate of CBF, in mechanically ventilated patients...
September 26, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/28962951/intracranial-aneurysms-in-adult-moyamoya-disease
#10
Jang Hun Kim, Taek-Hyun Kwon, Jong Hyun Kim, Kyuha Chong, Won-Ki Yoon
BACKGROUND: Reportedly, the prevalence of aneurysm formation in adults with Moyamoya disease (MMD) is approximately 14%, and it represents a major potential hemorrhagic risk. OBJECTIVES: We aimed to study the characteristics of intracranial aneurysms occurring in patients with MMD. We retrospectively reviewed our 10-year-experience of patients with intracranial aneurysms who visited our hospital and were diagnosed as having MMD. METHODS: We retrospectively reviewed radiological and clinical records of 211 patients who were admitted to our hospital between January 2007 and December 2016 and were diagnosed with MMD...
September 26, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28962888/nonsyndromic-peripheral-pulmonary-artery-stenosis-is-associated-with-homozygosity-of-rnf213-p-arg4810lys-regardless-of-co-occurrence-of-moyamoya-disease
#11
Sung-A Chang, Ju Sun Song, Taek Kyu Park, Jeong Hoon Yang, Woo Chan Kwon, So Ree Kim, Sung Mok Kim, Jihoon Cha, Shin Yi Jang, Young Seok Cho, Tae Jung Kim, Oh Young Bang, Jin Young Song, Chang-Seok Ki, Duk-Kyung Kim
BACKGROUND: Peripheral pulmonary arterial stenosis (PPAS) in childhood is frequently associated with other syndromes; however, PPAS in adolescents and adults is rare and its etiology is not well understood. We report the clinical characteristics of adult-onset nonsyndromic PPAS associated with the p.Arg4810Lys variant of the RNF213 gene. METHODS: We recently encountered an index case of severe pulmonary hypertension with multiple PPAS and intra- and extracranial arteriopathy...
September 28, 2017: Chest
https://www.readbyqxmd.com/read/28958924/moyamoya-disease-associated-with-tuberculum-sellae-meningioma-and-cavernous-sinus-hemangioma-case-report
#12
Feng Xu, Hailiang Tang, Ji Xiong, Xiaoxia Liu
BACKGROUND: Primary moyamoya disease associated with skull base tumors has been rarely reported in the literature. Surgical treatment can be complicated due to the compensatory collateral circulation through meningeal and leptomeningeal anastomosis. The standard frontotemporal craniotomy may interrupt critical transdural anastomoses. CASE DESCRIPTION: We reported a case of primary moyamoya disease coexisting with tuberculum sellae meningioma and left cavernous sinus hemangioma...
September 25, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28939540/long-term-patency-of-posterior-auricular-artery-middle-cerebral-artery-bypass-for-adult-onset-moyamoya-disease-case-report-and-review-of-literature
#13
Seiei Torazawa, Hirotaka Hasegawa, Taichi Kin, Hiroaki Sato, Shigeo Sora
BACKGOUND: Direct extracranial-intracranial (EC-IC) bypass is one of the fundamental techniques to prevent recurrent stroke in patients with adult-onset ischemic moyamoya disease. When the standard superficial temporal artery (STA) cannot be used for a graft, the posterior auricular artery (PAA) can be a potential surrogate graft. CASE DESCRIPTION: In this article, the authors reported a 34-year-old female patient suffering from ischemic moyamoya disease. To widely revascularize the anterior half of the hemisphere, direct double EC-IC bypass was considered beneficial; however, she had only a single-branched STA but had a prominent branch of the PAA...
September 19, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28931766/differences-in-the-genotype-frequency-of-the-rnf213-variant-in-patients-with-familial-moyamoya-disease-in-kyushu-japan
#14
Yuichiro Takamatsu, Ken Higashimoto, Toshiyuki Maeda, Masatou Kawashima, Muneaki Matsuo, Tatsuya Abe, Toshio Matsushima, Hidenobu Soejima
The p.R4810K (rs11273543, c.14429G > A) variant of the RNF213 gene is associated with increased risk of Moyamoya disease (MMD), which is an idiopathic progressive intracranial vascular steno-occlusive disease, in Asian populations. Numerous variant association studies for this MMD variant have been performed in Japan to date. Since another genetic study that utilized approximately 140,000 single nucleotide polymor (SNPs) has indicated that there still are genetic differences among mainland Japanese, there is a possibility that the variant distribution in patients with MMD and normal individuals varies between different Japanese regions...
September 21, 2017: Neurologia Medico-chirurgica
https://www.readbyqxmd.com/read/28927919/results-of-conservative-follow-up-or-surgical-treatment-of-mayamoya-patients-who-present-without-hemorrhage-tia-or-stroke
#15
Rutao Luo, Faliang Gao, Xiaofeng Deng, Dong Zhang, Yan Zhang
OBJECTIVE: The epidemiology of asymptomatic Moyamoya disease (MMD) is still unclear, and the best management remains controversial. The aim of this study is to evaluate the prognosis of these patients with different management, conservative follow-up or surgical treatment. METHODS: This prospective cohort study screened a series of 696 consecutive MMD patients from 2009 to 2015. Patients with any episodes of hemorrhage and ischemic stroke or TIA were excluded. Finally, 61 patients who were followed up for at least 12 months were included, with 52 patients underwent surgical treatment and 9 patients underwent conservative follow-up...
September 16, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28927214/direct-anastomosis-using-occipital-artery-for-additional-revascularization-in-moyamoya-disease-after-combined-superficial-temporal-artery-middle-cerebral-artery-and-indirect-bypass
#16
Ken Kazumata, Hiroyasu Kamiyama, Hisayasu Saito, Katsuhiko Maruichi, Masaki Ito, Haruto Uchino, Naoki Nakayama, Satoshi Kuroda, Kiyohiro Houkin
BACKGROUND: The posterior cerebral artery (PCA) is involved in approximately 30% of moyamoya disease (MMD) cases. However, there have been insufficient reports describing revascularization techniques in the posterior portion of the brain, particularly of direct anastomosis. OBJECTIVE: To perform a technical assessment in patients with MMD who underwent either occipital artery (OA)-PCA bypass or OA-middle cerebral artery (MCA) bypass. METHODS: A total of 428 revascularization procedures in 368 patients were retrospectively assessed by reviewing clinical charts and radiological data...
April 1, 2017: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/28925313/hemodynamics-and-oxygen-extraction-in-chronic-large-artery-steno-occlusive-disease-clinical-applications-for-predicting-stroke-risk
#17
Colin P Derdeyn
Depending on the adequacy of collateral sources of blood flow, arterial stenosis or occlusion may lead to reduced perfusion pressure and ultimately reduced blood flow in the distal territory supplied by that vessel. There are two well-defined compensatory mechanisms to reduced pressure or flow - autoregulatory vasodilation and increased oxygen extraction fraction. Other changes, such as metabolic downregulation, are likely. The positive identification of autoregulatory vasodilation and increased oxygen extraction fraction in humans is an established risk factor for future ischemic stroke in some disease states such as atherosclerotic carotid stenosis and occlusion...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/28921308/pregnancy-and-delivery-in-moyamoya-vasculopathy-experience-of-a-single-european-institution
#18
G├╝liz Acker, Marcus Czabanka, Peter Schmiedek, Peter Vajkoczy
Moyamoya vasculopathy (MMV) is a stenoocclusive cerebrovascular disease frequently affecting adolescent females. Thus, the management of pregnancy is of major interest for physicians dealing with MMV patients. However, clinical data concerning pregnant MMV patients is lacking. Our aim was to analyze the course of pregnancy in our European MMV patient cohort. We retrospectively identified MMV patients with a history of pregnancy who were treated in our institution. We analyzed demographic data, clinical symptoms, treatment, and detailed history of pregnancies...
September 18, 2017: Neurosurgical Review
https://www.readbyqxmd.com/read/28915102/acceleration-selective-arterial-spin-labeling-mr-angiography-used-to-visualize-distal-cerebral-arteries-and-collateral-vessels-in-moyamoya-disease
#19
Osamu Togao, Akio Hiwatashi, Makoto Obara, Koji Yamashita, Kazufumi Kikuchi, Ryotaro Kamei, Ataru Nishimura, Koichi Arimura, Koji Yoshimoto, Koji Iihara, Marc Van Cauteren, Hiroshi Honda
Purpose To evaluate and compare the performance of acceleration-selective arterial spin labeling (AccASL) magnetic resonance (MR) angiography in the visualization of cerebral arteries and collateral vessels in patients with Moyamoya disease with that of time-of-flight (TOF) MR angiography, with digital subtraction angiography (DSA) as the reference standard. Materials and Methods Thirty-six cerebral hemispheres from 22 patients with Moyamoya disease underwent TOF and AccASL MR angiography and DSA. Qualitative evaluations included imaging of the terminal internal carotid artery (ICA), distal middle cerebral arteries (MCAs), Moyamoya vessels, and leptomeningeal anastomosis (LMA) collaterals with reference to DSA...
September 15, 2017: Radiology
https://www.readbyqxmd.com/read/28893695/chronological-evaluation-of-cerebral-hemodynamics-by-dynamic-susceptibility-contrast-magnetic-resonance-imaging-after-indirect-bypass-surgery-for-moyamoya-disease
#20
Yosuke Ishii, Yoji Tanaka, Toshiya Momose, Motoshige Yamashina, Akihito Sato, Shinichi Wakabayashi, Taketoshi Maehara, Tadashi Nariai
OBJECTIVE: Although indirect bypass surgery is an effective treatment option for patients with ischemic-onset moyamoya disease (MMD), the time point after surgery at which the patients' hemodynamic status starts to improve and the time point at which the improvement reaches a maximum have not been known. The objective of present study is to evaluate the hemodynamic status time course after indirect bypass surgery for MMD, using dynamic susceptibility contrast-magnetic resonance imaging (DSC-MRI)...
September 8, 2017: World Neurosurgery
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