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Extracorporeal photopheresis

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https://www.readbyqxmd.com/read/28220931/the-role-of-extracorporeal-photopheresis-in-the-management-of-cutaneous-t-cell-lymphoma-graft-versus-host-disease-and-organ-transplant-rejection-a-consensus-statement-update-from-the-uk-photopheresis-society
#1
Arun Alfred, Peter C Taylor, Fiona Dignan, Khaled El-Ghariani, James Griffin, Andrew R Gennery, Denise Bonney, Emma Das-Gupta, Sarah Lawson, Ram K Malladi, Kenneth W Douglas, Tracey Maher, Julie Guest, Laura Hartlett, Andrew J Fisher, Fiona Child, Julia J Scarisbrick
Extracorporeal photopheresis (ECP) has been used for over 35 years in the treatment of erythrodermic cutaneous T-cell lymphoma (CTCL) and over 20 years for chronic and acute graft-versus-host disease (GvHD) and solid organ transplant rejection. ECP for CTCL and GvHD is available at specialised centres across the UK. The lack of prospective randomised trials in ECP led to the development of UK Consensus Statements for patient selection, treatment schedules, monitoring protocols and patient assessment criteria for ECP...
February 21, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/28094112/extracorporeal-photopheresis-for-bronchiolitis-obliterans-syndrome-after-allogeneic-stem-cell-transplant-an-emerging-therapeutic-approach
#2
REVIEW
Claudia Del Fante, Cesare Perotti
Bronchiolitis obliterans syndrome (BOS) is the main manifestation of pulmonary GVHD. It has often a dramatic and fast evolution and current treatment (change or increase in immunosuppression, macrolides and inhaled therapy) is poor with high mortality rates. In this scenario, extracorporeal photopheresis (ECP) bursts as a new immunomodulatory approach with a different philosophical purpose. In fact, available data show that ECP treatment is intended to delay the inflammatory process and consequently respiratory lung function decline, rather than reverse the damage itself...
January 13, 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/27976780/a-method-for-the-quantification-of-8-methoxypsoralen-by-mass-spectrometry-for-offline-extracorporeal-photopheresis
#3
Viola Hähnel, Frauke Dormann, Athanasios Nitsopoulos, Albrecht Friedle, Norbert Ahrens
BACKGROUND: Extracorporeal photopheresis (ECP) is an efficient method to treat various autoimmune diseases, cutaneous T-cell lymphoma, and graft-versus-host disease. It is based on the ex vivo inactivation of lymphocytes by 8-methoxypsoralen (8-MOP)/UV light treatment. Despite the adhesive, lipophilic nature of 8-MOP, no quality control is established for the ECP procedure. METHODS: We developed a sensitive high-performance liquid chromatography/tandem mass spectrometry (HPLC-MS/MS) assay to monitor residual 8-MOP concentration after UVA irradiation in the whole blood supernatant after acetonitrile precipitation...
December 15, 2016: Photochemical & Photobiological Sciences
https://www.readbyqxmd.com/read/27891662/acute-mechanical-hemolysis-as-a-complication-of-extracorporeal-photopheresis-in-a-low-weight-child
#4
Robert A DeSimone, Sandeep N Wontakal, Alexander K Lyashchenko, Joseph Schwartz
Graft-versus-host disease (GVHD) is a complication of allogeneic hematopoietic stem cell transplantation with high morbidity and mortality. Extracorporeal photopheresis (ECP) is an effective therapy for treating medication-refractory GVHD, however, there is scant evidence of whether ECP can be safely performed in patients weighing less than 15 kg. Here, we report the implementation of a successful protocol to perform ECP in a 21-month-old, 10.6 kg female with medication-refractory GVHD. Our initial ECP treatment resulted in significant hemolysis that was most likely mechanical...
November 28, 2016: Journal of Clinical Apheresis
https://www.readbyqxmd.com/read/27861297/extracorporeal-photopheresis-for-treatment-of-acute-and-chronic-graft-versus-host-disease-an-italian-multicentric-retrospective-analysis-on-94-patients-on-behalf-of-the-gruppo-italiano-trapianto-di-midollo-osseo
#5
Michele Malagola, Valeria Cancelli, Cristina Skert, Pierino Ferremi Leali, Emilio Ferrari, Alessandra Tiburzi, Maria Luisa Sala, Irene Donnini, Patrizia Chiusolo, Alberto Mussetti, Marta Battista, Alessandro Turra, Federica Cattina, Benedetta Rambaldi, Francesca Schieppati, Nicola Polverelli, Simona Bernardi, Simone Perucca, Mirella Marini, Daniele Laszlo, Chiara Savignano, Francesca Patriarca, Paolo Corradini, Nicola Piccirillo, Simona Sica, Alberto Bosi, Domenico Russo
BACKGROUND: Extracorporeal photopheresis (ECP) is considered a valid second-line treatment for acute and chronic graft versus host disease (GVHD). METHODS: Ninety-four patients with acute GVHD (aGVHD) (n = 45) and chronic GVHD (cGVHD) (n = 49), retrospectively recruited in 6 Italian centers, were submitted to ECP for second-line treatment. At the time of ECP, 22 (49%) and 23 (51%) of 45 patients with aGHVD were nonresponsive and in partial remission (PR) after steroids, respectively, and all the 49 patients with cGVHD were steroid refractory...
December 2016: Transplantation
https://www.readbyqxmd.com/read/27741338/75-complete-response-and-15-partial-response-to-extracorporeal-photopheresis-combined-with-other-therapies-in-resistant-early-stage-cutaneous-t-cell-lymphoma
#6
Sila Seremet, Sunil Abhyankar, Tiffany J Herd, Daniel Aires
INTRODUCTION: Extracorporeal photopheresis (ECP) has been used for the treatment of advanced stage or treatment refractory cutaneous T-cell lymphoma (CTCL) since 1987, and more recently has also been shown to be of benefit for earlier stage resistant CTCL. Complete response rates in prior studies of ECP in early CTCL have ranged from 0% to 40%. METHODS: We reviewed electronic medical records of all CTCL patients seen in the University of Kansas Cancer Center between June 2007 and May 2011...
October 1, 2016: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/27687726/psoralen-and-ultraviolet-a-light-treatment-directly-affects-phosphatidylinositol-3-kinase-signal-transduction-by-altering-plasma-membrane-packing
#7
Britt Van Aelst, Rosalie Devloo, Pierre Zachée, Ruben t'Kindt, Koen Sandra, Philippe Vandekerckhove, Veerle Compernolle, Hendrik B Feys
Psoralen and ultraviolet A light (PUVA) are used to kill pathogens in blood products and as a treatment of aberrant cell proliferation in dermatitis, cutaneous T-cell lymphoma, and graft-versus-host disease. DNA damage is well described, but the direct effects of PUVA on cell signal transduction are poorly understood. Because platelets are anucleate and contain archetypal signal transduction machinery, they are ideally suited to address this. Lipidomics on platelet membrane extracts showed that psoralen forms adducts with unsaturated carbon bonds of fatty acyls in all major phospholipid classes after PUVA...
November 18, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27643864/cryopreservation-as-a-way-to-maintain-extracorporeal-photopheresis-regimen-for-gvhd-treatment-while-circumventing-patient-temporary-inability-to-undergo-apheresis
#8
C Pochon, L Reppel, P Halle, A Zang, L Clément, D Michel, A Perrot, G Roth-Guépin, M Detrait, J Kanold, N Rouel, B Donzé, V Décot, S Mathieu-Nafissi, E Merlin, D Bensoussan
No abstract text is available yet for this article.
January 2017: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/27615528/improving-the-service-for-patients-receiving-extracorporeal-photopheresis-using-lean-principles
#9
Cherie Rushton, Leeah Robertson, Tracie Taylor, Peter Taylor, Paul Button, Arun Alfred
The photopheresis unit where the authors work has seen an increased demand both locally and as an outreach service. A Lean assessment of the unit was undertaken to improve processing time and productivity, which in turn would improve the availability of treatment and improve patient care. The assessment indicated that there were excellent nursing standards and patient care; however, patient waiting times and treatment times were prolonged in comparison with other units. The unit reviewed the patient pathway and identified where delays occurred and consequently changed patient scheduling...
September 8, 2016: British Journal of Nursing: BJN
https://www.readbyqxmd.com/read/27612294/extracorporeal-photopheresis-did-not-prevent-the-development-of-an-autoimmune-disease-myasthenia-gravis
#10
Vedat Uygun, Hayriye Daloğlu, Seda Irmak Öztürkmen, Levent Döşemeci, Gülsün Karasu, Volkan Hazar, Akif Yeşilipek
BACKGROUND: Myasthenia gravis (MG) is a neuromuscular disorder characterized by an autoimmune defect in the neuromuscular junction. In most patients, the autoimmune attack is mediated by antibodies against the acetylcholine receptor (AChR) on the postsynaptic membrane. Deficient immunoregulation, including regulatory T cells, is consistently observed. Extracorporeal photopheresis (ECP) leads to the induction of regulatory T cells that mediate immunologic tolerance in autoimmune diseases; however, the data regarding MG are very limited...
December 2016: Transfusion
https://www.readbyqxmd.com/read/27607528/extracorporeal-photopheresis-ecp-for-treatement-of-acute-and-chronic-graft-versus-host-disease-an-italian-multicentric-retrospective-analysis-on-94-patients-on-behalf-of-the-gruppo-italiano-trapianto-di-midollo-osseo-gitmo
#11
Michele Malagola, Valeria Cancelli, Cristina Skert, Pierino Ferremi Leali, Emilio Ferrari, Alessandra Tiburzi, Maria Luisa Sala, Irene Donnini, Patrizia Chiusolo, Alberto Muffetti, Marta Battista, Alessandro Turra, Federica Cattina, Benedetta Rambaldi, Francesca Schieppati, Nicola Polverelli, Simona Bernardi, Simone Perucca, Mirella Marini, Daniele Laszlo, Chiara Savignano, Francesca Patriarca, Paolo Corradini, Nicola Piccirillo, Simona Sica, Alberto Bosi, Domenico Russo
BACKGROUND: Extracorporeal photopheresis (ECP) is considered a valid second-line treatment for acute and chronic graft versus host disease (GVHD). METHODS: Ninety-four patients with aGVHD (n=45) and cGVHD (n=49), retrospectively recruited in 6 Italian Centers, were submitted to ECP for second-line treatment. At the time of ECP, 22 (49%) and 23 (51%) out of 45 patients with aGHVD were non responsive (NR) and in partial remission (PR) after steroids, respectively, and all the 49 patients with cGVHD were steroid refractory...
September 8, 2016: Transplantation
https://www.readbyqxmd.com/read/27583569/x-ray-psoralen-activated-cancer-therapy-x-pact
#12
Mark Oldham, Paul Yoon, Zak Fathi, Wayne F Beyer, Justus Adamson, Leihua Liu, David Alcorta, Wenle Xia, Takuya Osada, Congxiao Liu, Xiao Y Yang, Rebecca D Dodd, James E Herndon, Boyu Meng, David G Kirsch, H Kim Lyerly, Mark W Dewhirst, Peter Fecci, Harold Walder, Neil L Spector
This work investigates X-PACT (X-ray Psoralen Activated Cancer Therapy): a new approach for the treatment of solid cancer. X-PACT utilizes psoralen, a potent anti-cancer therapeutic with current application to proliferative disease and extracorporeal photopheresis (ECP) of cutaneous T Cell Lymphoma. An immunogenic role for light-activated psoralen has been reported, contributing to long-term clinical responses. Psoralen therapies have to-date been limited to superficial or extracorporeal scenarios due to the requirement for psoralen activation by UVA light, which has limited penetration in tissue...
2016: PloS One
https://www.readbyqxmd.com/read/27476149/extracorporeal-photopheresis-as-an-immunomodulatory-agent-haematocrit-depependent-effects-on-natural-killer-cells
#13
V Becherucci, E Allegro, F Brugnolo, L Piccini, V Gori, S Bisin, B Bindi, R Ceccantini, P Pavan, V Cunial, F Gentile, S Ermini, F Bambi
The GvHD is a major cause of morbidity and mortality after allogeneic hematopoietic stem cell transplantation (HSCT). Extracorporeal photopheresis (ECP) represents an alternative therapeutic strategy to immunosuppressive therapy. Although ECP is used since 1990s, the mechanism of action has not yet been completely clarified. We analyzed cells collected from 20 ECP procedures of 4 patients affected by chronic GvHD and, for comparison, Peripheral Blood Mononuclear Cells (PBMCs) of 10 healthy donors undergoing from same type of photochemiotherapy, evaluating by flow cytometry, the effects before and after photoactivation with 8-MOP...
July 31, 2016: Journal of Clinical Apheresis
https://www.readbyqxmd.com/read/27456672/technical-comparison-of-four-different-extracorporeal-photopheresis-systems
#14
Andreas Brosig, Viola Hähnel, Evelyn Orsó, Daniel Wolff, Ernst Holler, Norbert Ahrens
BACKGROUND: Extracorporeal photopheresis (ECP) is a therapeutic technique that combines leukapheresis and ultraviolet (UV)A irradiation of the leukapheresate after 8-methoxypsoralen treatment with subsequent retransfusion. It can be achieved with a single device (online) or by combining an apheresis machine with a separate UVA light source (offline). The comparability of both established methods is unknown. STUDY DESIGN AND METHODS: In a prospective setting, four ECP systems were evaluated: one with integrated UVA irradiation for online ECP (Therakos) and three with external UVA irradiation for offline ECP (Amicus, Optia, and Cobe Spectra)...
October 2016: Transfusion
https://www.readbyqxmd.com/read/27442906/extracorporeal-photopheresis-practice-patterns-an-international-survey-by-the-asfa-ecp-subcommittee
#15
Nancy M Dunbar, Jay S Raval, Andrew Johnson, Cori M Abikoff, Jill Adamski, Laura L Cooling, Brenda Grossman, Haewon C Kim, Marisa B Marques, Shanna Morgan, Amy E Schmidt, Steven R Sloan, Leon L Su, Zbigniew M Szczepiorkowski, F Bernadette West, Edward Wong, Jennifer Schneiderman
BACKGROUND: Although many apheresis centers offer extracorporeal photopheresis (ECP), little is known about current treatment practices. METHODS: An electronic survey was distributed to assess ECP practice internationally. RESULTS: Of 251 responses, 137 met criteria for analysis. Most respondents were from North America (80%). Nurses perform ECP at most centers (84%) and the majority of centers treat adults only (52%). Most centers treat fewer than 50 patients/year (83%) and perform fewer than 300 procedures/year (70%)...
July 21, 2016: Journal of Clinical Apheresis
https://www.readbyqxmd.com/read/27436448/treatment-of-necrobiotic-xanthogranuloma-a-systematic-review
#16
REVIEW
D Miguel, J Lukacs, T Illing, P Elsner
Necrobiotic xanthogranuloma (NXG) is an uncommon non-Langerhans cell histiocytosis involving skin and extracutaneous tissues. The lesions are usually asymptomatic and commonly appear in the periorbital area. Paraproteinemia is closely associated with NXG and its pathogenesis remains unclear. NXG prognosis is poor with several treatments showing variable results. Treatment of monoclonal gammopathy with alkylating agents does not necessarily influence the activity of the skin disease and vice versa. The aim of this systematic review is to summarize all reported treatments of necrobiotic xanthogranuloma of the skin, with or without underlying malignant condition and based on articles from the PubMed database using the query 'necrobiotic xanthogranuloma treatment', both in English and German, about 'human' subjects and published between 1980 and 2014, documenting adequate treatment for NXG...
February 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/27408705/extracoporeal-photopheresis-treatment-of-acute-graft-versus-host-disease-following-allogeneic-haematopoietic-stem-cell-transplantation
#17
REVIEW
Aisling M Flinn, Andrew R Gennery
Acute graft-versus-host disease (aGvHD) continues to be a major obstacle to allogeneic haematopoietic stem cell transplantation. Thymic damage secondary to aGvHD along with corticosteroids and other non-selective T lymphocyte-suppressive agents used in the treatment of aGvHD concurrently impair thymopoiesis and negatively impact on immunoreconstitution of the adaptive immune compartment and ultimately adversely affect clinical outcome. Extracorporeal photopheresis (ECP) is an alternative therapeutic strategy that appears to act in an immunomodulatory fashion, potentially involving regulatory T lymphocytes and dendritic cells...
2016: F1000Research
https://www.readbyqxmd.com/read/27317354/induction-of-anti-tumor-cd8-t-cell-responses-by-experimental-ecp-induced-human-dendritic-antigen-presenting-cells
#18
N Kibbi, O Sobolev, M Girardi, R L Edelson
Extracorporeal photochemotherapy (ECP), or photopheresis, is distinguished by the specificity of the clinically potent immunologic reactions it initiates or regulates. The selectivity of ECP-induced immunoprotection for the malignant clone in cutaneous T cell lymphoma (CTCL), and for the pathogenic clones in allograft rejection and graft-versus-host disease (GVHD), has suggested a central mechanistic role for dendritic antigen presenting cells (DC). Discovery of ECP's induction of monocyte-derived DC, via monocyte signaling by ECP-plate activated platelets, and the absolute dependency of experimental ECP on such induced DC, supports that premise...
August 2016: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/27301678/selective-photodepletion-of-malignant-t-cells-in-extracorporeal-photopheresis-with-selenorhodamine-photosensitizers
#19
Zachariah A McIver, Mark W Kryman, Young Choi, Benjamin N Coe, Gregory A Schamerhorn, Michelle K Linder, Kellie S Davies, Jacqueline E Hill, Geri A Sawada, Jason M Grayson, Michael R Detty
Extracorporeal photopheresis (ECP) has been used successfully in the treatment of erythrodermic cutaneous T cell lymphoma (CTCL), and other T cell-mediated disorders. Not all patients obtain a significant or durable response from ECP. The design of a selective photosensitizer that spares desirable lymphocytes while targeting malignant T cells may promote cytotoxic T cell responses and improve outcomes after ECP. A series of selenorhodamines built with variations of the Texas red core targeted the mitochondria of malignant T cells, were phototoxic to malignant T cells presumably via their ability to generate singlet oxygen, and were transported by P-glycoprotein (P-gp)...
September 1, 2016: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/27250563/comparison-of-two-automated-mononuclear-cell-collection-systems-in-patients-undergoing-extracorporeal-photopheresis-a-prospective-crossover-equivalence-study
#20
Claudia Del Fante, Luigia Scudeller, Alberto Martinasso, Gianluca Viarengo, Cesare Perotti
BACKGROUND: Extracorporeal photopheresis (ECP) is an effective cell therapy employed in several diseases, including graft versus host disease (GVHD) and organ rejection. When ECP is performed using an off-line technique, mononuclear cell (MNC) collection by leukapheresis is necessary for further manipulation (addition of 8-methoxypsoralen and ultraviolet A irradiation before reinfusion to the patient). We report the results of the first crossover equivalence study on yield and purity of MNCs collected from patients undergoing ECP with two different automated systems: MNC and CMNC (working with intermittent and continuous-flow collection, respectively), released by Terumo BCT...
August 2016: Transfusion
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