M Farina, M C Scaini, A Facchinetti, A Leoni, S Bernardi, C Catoni, E Morello, V Radici, Filippo Frioni, E Campodonico, G Traverso, G Cavallaro, A Olivieri, P Galieni, N Di Renzo, F Patriarca, P Carluccio, C Skert, E Maffini, S Pellizzeri, G Campisi, F Re, E Benedetti, A Rosato, C Almici, P Chiusolo, J Peccatori, M Malagola, C Poggiana, D Russo
Sinusoidal obstruction syndrome (SOS), also known as veno-occlusive disease (VOD), is a rare but potentially fatal complication following allogenic hematopoietic cell transplantation (allo-HCT). Timely identification of SOS/VOD for prompt treatment is critical, but identifying a VOD predictive biomarker is still challenging. Given the pivotal role of endothelial dysfunction in SOS/VOD pathophysiology, the CECinVOD study prospectively evaluated Circulating Endothelial Cells (CEC) levels in patients undergoing allo-HCT with myeloablative conditioning regimens (MAC) to investigate their potential in predicting and diagnosing SOS/VOD...
April 4, 2024: Transplantation and cellular therapy