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https://www.readbyqxmd.com/read/27911225/successful-treatment-of-mixed-yolk-sac-tumor-and-mature-teratoma-in-the-spinal-cord-case-report
#1
Akitake Mukasa, Shunsuke Yanagisawa, Kuniaki Saito, Shota Tanaka, Keisuke Takai, Junji Shibahara, Masachika Ikegami, Yusuke Nakao, Katsushi Takeshita, Masao Matsutani, Nobuhito Saito
Primary spinal germ cell tumors are rare, and spinal nongerminomatous germ cell tumors represent an even rarer subset for which no standard therapy has been established. The authors report the case of a 24-year-old woman with multifocal primary spinal germ cell tumors scattered from T-12 to L-5 that consisted of yolk sac tumor and mature teratoma. After diagnostic partial resection, the patient was treated with 30 Gy of craniospinal irradiation and 30 Gy of local spinal irradiation, followed by 8 courses of chemotherapy based on ifosfamide, cisplatin, and etoposide (ICE)...
December 2, 2016: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/27909481/ice-guided-crt-is-there-evidence-of-reverse-remodeling
#2
REVIEW
Antonio Rossillo Md, Angelo B Ramondo Md
Cardiac resynchronization therapy (CRT) is an accepted treatment for patients with heart failure (HF), impaired left ventricular (LV) function, and a wide QRS complex. However, more than 30% of eligible patients fail to benefit from CRT. It is clearly necessary to define the characteristics of the best candidates for this therapy. To this end, surface ECG and echocardiography have been tested. Unfortunately, however, neither of these examinations has proved sufficiently able to identify the best patients. A tailored approach based on the evaluation of both electrical and mechanical delay to guide LV lead placement seems to be the most reasonable strategy in order to increase the efficacy of CRT therapy...
February 2016: Journal of Atrial Fibrillation
https://www.readbyqxmd.com/read/27905926/understanding-clinical-and-non-clinical-decisions-under-uncertainty-a-scenario-based-survey
#3
Vlad V Simianu, Margaret A Grounds, Susan L Joslyn, Jared E LeClerc, Anne P Ehlers, Nidhi Agrawal, Rafael Alfonso-Cristancho, Abraham D Flaxman, David R Flum
BACKGROUND: Prospect theory suggests that when faced with an uncertain outcome, people display loss aversion by preferring to risk a greater loss rather than incurring certain, lesser cost. Providing probability information improves decision making towards the economically optimal choice in these situations. Clinicians frequently make decisions when the outcome is uncertain, and loss aversion may influence choices. This study explores the extent to which prospect theory, loss aversion, and probability information in a non-clinical domain explains clinical decision making under uncertainty...
December 1, 2016: BMC Medical Informatics and Decision Making
https://www.readbyqxmd.com/read/27849130/treatment-of-muscle-injuries-in-football
#4
Peter Ueblacker, Lutz Haensel, Hans-Wilhelm Mueller-Wohlfahrt
Muscle injuries are frequent and represent one of the most substantial medical problems in professional football. They can have both traumatic and overuse causes with direct practical consequence due to differences in terms of the post-primary care regimen and prognosis. An accurate diagnosis is the first step towards a specific treatment and usually allows to predict return to play (RTP). Current treatment principles have no firm scientific basis; they are practiced largely as empirical medicine due to a lack of prospective randomised studies...
November 16, 2016: Journal of Sports Sciences
https://www.readbyqxmd.com/read/27846029/nonhealing-wounds-caused-by-brown-spider-bites-application-of-hyperbaric-oxygen-therapy
#5
Amir Hadanny, Gregory Fishlev, Yair Bechor, Oshra Meir, Shai Efrati
BACKGROUND: Bites by Loxosceles spiders (also known as recluse spiders or brown spiders) can cause necrotic ulcerations of various sizes and dimensions. The current standard of care for brown spider bites includes analgesics, ice, compression, elevation, antihistamines, and surgical debridement. Hyperbaric oxygen therapy (HBOT) in the treatment of brown spider bites has been administered in the early stage of ulceration, or 2 to 6 days after the bite. Unfortunately, the diagnosis of spider bite-related ulcers is often delayed and weeks or months may elapse before HBOT is considered...
December 2016: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/27833151/the-cytotoxic-synergy-of-nanosecond-electric-pulses-and-low-temperature-leads-to-apoptosis
#6
Claudia Muratori, Andrei G Pakhomov, Elena C Gianulis, Sarah Damsbo Jensen, Olga N Pakhomova
Electroporation by nanosecond electric pulses (nsEP) is an emerging modality for tumor ablation. Here we show the efficient induction of apoptosis even by a non-toxic nsEP exposure when it is followed by a 30-min chilling on ice. This chilling itself had no impact on the survival of U-937 or HPAF-II cells, but caused more than 75% lethality in nsEP-treated cells (300 ns, 1.8-7 kV/cm, 50-700 pulses). The cell death was largely delayed by 5-23 hr and was accompanied by a 5-fold activation of caspase 3/7 (compared to nsEP without chilling) and more than 60% cleavage of poly-ADP ribose polymerase (compared to less than 5% in controls or after nsEP or chilling applied separately)...
November 11, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27805556/-innate-receptors-and-il-17-in-the-immune-response-against-human-pathogenic-fungi
#7
REVIEW
Marìa Soledad Miro, Cecilia Vigezzi, Emilse Rodriguez, Paula Alejandra Icely, Juan Pablo Caeiro, Fernando Riera, Diana Teresa Masih, Claudia Elena Sotomayor
In recent years, the rise of human fungal infections has been associated to lack of early diagnosis, uneffective antifungal therapies and vaccines. Disturbance in immune homeostasis, which can be caused by medical interventions and immunosuppression nduced by disease, are well known as risk factors for these pathologies. Cells of the innate immune system are equipped with surface and cytoplasmic receptors for recognition of microorganisms called pattern recognition receptors (PRRs). PRRs recognize specific pathogen-associated molecular patterns (PAMPs) that are crucial for the activation and killing of pathogenic fungi by immune system...
2016: Revista de la Facultad de Ciencias Médicas
https://www.readbyqxmd.com/read/27758940/ices-intraoperative-stereotactic-computed-tomography-guided-endoscopic-surgery-for-brain-hemorrhage-a-multicenter-randomized-controlled-trial
#8
Paul Vespa, Daniel Hanley, Joshua Betz, Alan Hoffer, Johnathan Engh, Robert Carter, Peter Nakaji, Chris Ogilvy, Jack Jallo, Warren Selman, Amanda Bistran-Hall, Karen Lane, Nichol McBee, Jeffery Saver, Richard E Thompson, Neil Martin
BACKGROUND AND PURPOSE: Intracerebral hemorrhage (ICH) is a devastating disease without a proven therapy to improve long-term outcome. Considerable controversy about the role of surgery remains. Minimally invasive endoscopic surgery for ICH offers the potential of improved neurological outcome. METHODS: We tested the hypothesis that intraoperative computerized tomographic image-guided endoscopic surgery is safe and effectively removes the majority of the hematoma rapidly...
November 2016: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/27740477/4-d-ice-a-2-d-array-transducer-with-integrated-asic-in-a-10-fr-catheter-for-real-time-3-d-intracardiac-echocardiography
#9
Douglas Wildes, Warren Lee, Bruno Haider, Scott Cogan, Krishnakumar Sundaresan, David M Mills, Christopher Yetter, Patrick H Hart, Christopher R Haun, Mikael Concepcion, Johan Kirkhorn, Marc Bitoun
We developed a 2.5 ×6.6 mm (2) 2 -D array transducer with integrated transmit/receive application-specific integrated circuit (ASIC) for real-time 3-D intracardiac echocardiography (4-D ICE) applications. The ASIC and transducer design were optimized so that the high-voltage transmit, low-voltage time-gain control and preamp, subaperture beamformer, and digital control circuits for each transducer element all fit within the 0.019-mm (2) area of the element. The transducer assembly was deployed in a 10-Fr (3...
December 2016: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
https://www.readbyqxmd.com/read/27720659/a-randomized-control-trial-measuring-the-effectiveness-of-a-mouth-exercising-device-for-mucosal-burning-in-oral-submucous-fibrosis
#10
Pravinkumar G Patil, Vinay Hazarey, Rekha Chaudhari, Smita Nimbalkar-Patil
OBJECTIVES: To evaluate effect of ice-cream stick exercise regimen with or without a mouth-exercising device (MED) on mucosal burning sensation in oral submucous fibrosis. STUDY DESIGN: In total, 282 patients with oral submucous fibrosis were treated with topical corticosteroid and oral antioxidant and the ice-cream stick exercise regimen. Patients in subgroups A1, A2, and A3 were additionally given a new MED. Patients in subgroups A1 and B1 patients with interincisal distance (IID) of 20 to 35 mm were managed without any additional therapy; patients in subgroups A2 and B2 with IID of 20 to 35 mm were additionally managed with intralesional injections; and those in subgroups A3 and B3 with IID less than 20 mm were managed surgically...
August 6, 2016: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/27695905/the-efficacy-of-post-operative-devices-following-knee-arthroscopic-surgery-a-systematic-review
#11
Corey T Gatewood, Andrew A Tran, Jason L Dragoo
PURPOSE: There is a wide array of device modalities available for post-operative treatment following arthroscopic knee surgery; however, it remains unclear which types and duration of modality are the most effective. This systematic review aimed to investigate the efficacy of device modalities used following arthroscopic knee surgery. METHODS: A systematic search of the literature was performed on: PubMed; Scopus; MEDLINE; EMBASE; PEDro; SportDiscus; and CINAHL databases (1995-2015) for clinical trials using device modalities following arthroscopic knee surgery: cryotherapy, continuous passive motion (CPM), neuromuscular electrical stimulation (NMES), surface electromyographic (sEMG) biofeedback and shockwave therapy (ESWT)...
October 1, 2016: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/27680664/left-atrial-appendage-closure-under-intracardiac-echocardiographic-guidance-feasibility-and-comparison-with-transesophageal-echocardiography
#12
Yae Matsuo, Petr Neuzil, Jan Petru, Milan Chovanec, Marek Janotka, Subbarao Choudry, Jan Skoda, Lucie Sediva, Masahiko Kurabayashi, Vivek Y Reddy
BACKGROUND: Transcatheter left atrial appendage closure is an alternative therapy for stroke prevention in atrial fibrillation patients. These procedures are currently guided with transesophageal echocardiography and fluoroscopy in most centers. As intracardiac echocardiography (ICE) is commonly used in other catheter-based procedures, we sought to determine the safety and effectiveness of intracardiac echocardiography-guided left atrial appendage closure with the Watchman device. METHODS AND RESULTS: A total of 27 patients (11 males, 77...
September 28, 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/27668364/potential-benefits-of-oral-cryotherapy-for-chemotherapy-induced-mucositis
#13
Amelia Wodzinski
Mucositis is a common side effect of cancer therapies that causes painful, erythematous lesions to develop in the gastrointestinal tract. These lesions can lead to malnutrition, increased risk for serious infection, prolonged hospital stays, and reduced quality of life. Oral cryotherapy, or the use of ice chips to cool the mucous membranes during bolus chemotherapy infusions (e.g., 5-fluorouracil [Adrucil®] and melphalan [Alkeran®]), is the most readily accessible and cost-effective intervention available...
October 1, 2016: Clinical Journal of Oncology Nursing
https://www.readbyqxmd.com/read/27659107/regulation-of-therapeutic-hypothermia-on-inflammatory-cytokines-microglia-polarization-migration-and-functional-recovery-after-ischemic-stroke-in-mice
#14
Jin Hwan Lee, Zheng Z Wei, Wenyuan Cao, Soonmi Won, Xiaohuan Gu, Megan Winter, Thomas A Dix, Ling Wei, Shan Ping Yu
Stroke is a leading threat to human life and health in the US and around the globe, while very few effective treatments are available for stroke patients. Preclinical and clinical studies have shown that therapeutic hypothermia (TH) is a potential treatment for stroke. Using novel neurotensin receptor 1 (NTR1) agonists, we have demonstrated pharmacologically induced hypothermia and protective effects against brain damages after ischemic stroke, hemorrhage stroke, and traumatic brain injury (TBI) in rodent models...
December 2016: Neurobiology of Disease
https://www.readbyqxmd.com/read/27630237/monitoring-integration-over-time-supports-a-role-for-cytotoxic-t-lymphocytes-and-ongoing-replication-as-determinants-of-reservoir-size
#15
Marilia Rita Pinzone, Erin Graf, Lindsay Lynch, Brigit McLaughlin, Frederick M Hecht, Mark Connors, Stephen A Migueles, Wei-Ting Hwang, Giuseppe Nunnari, Una O'Doherty
: The dynamics of HIV reservoir accumulation off antiretroviral therapy (ART) is underexplored. Levels of integrated HIV DNA in peripheral blood mononuclear cells (PBMCs) were longitudinally monitored before and after antiviral therapy. HIV integration increased over time in both elite controllers (ECs; n = 8) and noncontrollers (NCs; n = 6) before ART, whereas integration remained stable in patients on ART (n = 4). The median annual fold change was higher in NCs than in ECs and negatively correlated with CD4/CD8 T-cell ratio...
December 1, 2016: Journal of Virology
https://www.readbyqxmd.com/read/27624781/photobiomodulation-therapy-pbmt-and-or-cryotherapy-in-skeletal-muscle-restitution-what-is-better-a-randomized-double-blinded-placebo-controlled-clinical-trial
#16
Paulo Roberto Vicente de Paiva, Shaiane Silva Tomazoni, Douglas Scott Johnson, Adriane Aver Vanin, Gianna Móes Albuquerque-Pontes, Caroline Dos Santos Monteiro Machado, Heliodora Leão Casalechi, Paulo de Tarso Camillo de Carvalho, Ernesto Cesar Pinto Leal-Junior
Cryotherapy for post-exercise recovery remains widely used despite the lack of quality evidence. Photobiomodulation therapy (PBMT) studies (with both low-level laser therapy and light-emitting diode therapy) have demonstrated positive scientific evidence to suggest its use. The study aims to evaluate PBMT and cryotherapy as a single or combined treatment on skeletal muscle recovery after eccentric contractions of knee extensors. Fifty healthy male volunteers were recruited and randomized into five groups (PBMT, cryotherapy, cryotherapy + PBMT, PMBT + cryotherapy, or placebo) for a randomized, double-blinded, placebo-controlled trial that evaluated exercise performance (maximum voluntary contraction (MVC)), delayed onset muscle soreness (DOMS), and muscle damage (creatine kinase (CK))...
December 2016: Lasers in Medical Science
https://www.readbyqxmd.com/read/27613331/application-of-a-novel-rectal-cooling-device-in-hypothermia-therapy-after-cerebral-hypoxia-ischemia-in-rats
#17
Peng Liu, Rui Yang, Zelan Zuo
BACKGROUND: A new rectal cooling device for therapeutic hypothermia (TH) therapy is designed and is applied in TH treatment of SD rats with ischemic-hypoxic brain damage. METHODS: Healthy adult SD rats (n = 45) were randomly assigned into four groups: the healthy control group (n = 5), the ischemia and hypoxia group (n = 10), the rectal TH cooling group (n = 18), and the ice blanket TH cooling group (n = 11). The rats in the rectal cooling and ice blanket TH groups received 12 h treatment after hypoxic-ischemic brain damage had been established, while those in the ischemia and hypoxia group did not...
2016: BMC Anesthesiology
https://www.readbyqxmd.com/read/27550824/ice-compresses-aid-the-reduction-of-swelling-and-pain-after-scleral-buckling-surgery
#18
Zhuo Li, Qin Wang
AIMS AND OBJECTIVES: To investigate the therapeutic effects of a local ice compress in alleviating eyelid swelling and errhysis and providing relief from pain after surgery. BACKGROUND: Eyelid swelling and pain are the most common postoperative symptoms after scleral buckling surgery. A local ice compress can reduce the severity of swelling, errhysis and pain after acute injury as well as after surgery. DESIGN: A retrospective study. METHODS: A total of 100 patients who had undergone scleral buckling surgery for retinal detachment were classified into an ice compress group or a control group...
November 2016: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/27540213/children-with-cystic-fibrosis-understanding-issues-related-to-oral-administration-of-liquid-flucloxacillin
#19
Hannah Batchelor, Oli Rayner, Jessica Nickless, Mandy Wan, Kevin Southern, Claudia Rose
AIM: Palatability of flucloxacillin is poor, yet is used long-term in the management of children with cystic fibrosis (CF). Strategies to aid administration of unpalatable medicines have been reported, however there has never been a systematic approach to gathering views of many parents/carers all administering the same medication to the same population of children. This study aimed to quantify the extent of flucloxacillin palatability issues for parents/cares of children with CF and identify parent/carer and healthcare professional (HCP) reported age-specific strategies to aid administration of flucloxacillin to children with CF...
September 2016: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/27509603/-clinical-efficacy-of-multi-pattern-detumescence-after-total-knee-arthroplasty-treated-with-acupoint-massage-and-mild-moxibustion
#20
RANDOMIZED CONTROLLED TRIAL
Qiaoling Chen, Shuangying Huang, Xiaoli Chen, Lei Feng, Xuxia Zhu
OBJECTIVE: To discuss the clinical effect on swelling and pain after total knee arthroplasty treated with acupoint massage, mild moxibustion and routine detumescence. METHODS: One hundred and twenty patients of knee osteoarthritis (KOA) after total knee arthroplasty (TKA), were randomized into an observation group and a control group, 60 cases in each one. In the control group, after TKA, the routine detumescence was applied, including elastic bandage compression, the operated limb raising exercise, knee joint braking, local ice compress, intermittent pneumatic compression, active ankle pumping and quadriceps contraction exercise, continuous passive mechanical exercise, using stretch socks, oral administration of rivaroxaban tablets, 10 mg, once a day, continuously for 21 to 24 days...
May 2016: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
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