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https://www.readbyqxmd.com/read/29306514/intermediate-endpoints-after-postprostatectomy-radiotherapy-5-year-distant-metastasis-to-predict-overall-survival
#1
William C Jackson, Krithika Suresh, Vasu Tumati, Steven G Allen, Robert T Dess, Simpa S Salami, Arvin George, Samuel D Kaffenberger, David C Miller, Jason W D Hearn, Shruti Jolly, Rohit Mehra, Brent K Hollenbeck, Ganesh S Palapattu, Matthew Schipper, Felix Y Feng, Todd M Morgan, Neil B Desai, Daniel E Spratt
BACKGROUND: Intermediate clinical endpoints (ICEs) prognostic for overall survival (OS) are needed for men receiving postprostatectomy radiation therapy (PORT) to improve clinical trial design. OBJECTIVE: To identify a potential ICE for men receiving PORT. DESIGN, SETTING, AND PARTICIPANTS: We performed an institutional review board-approved multi-institutional retrospective study of 566 men consecutively treated with PORT at tertiary care centers from 1986 to 2013...
January 3, 2018: European Urology
https://www.readbyqxmd.com/read/29304516/ablative-fractional-co2-laser-for-facial-atrophic-acne-scars
#2
Yaqin Xu, Yunhua Deng
Ablative fractional carbon dioxide laser resurfacing is a well-established treatment for acne scars. However, there are limited consensus and guidelines regarding the procedure, such as its treatment plan, efficacy, and safety. In this study, we performed a systematic review to assess the efficacy and safety of the fractional carbon dioxide laser treatment procedure, and to provide evidence-based recommendations concerning its practical use on atrophic acne scars. A comprehensive search was performed in, EMBASE, Ovid, Web of Science, and Cochrane databases, using the keywords "scar(s)," "acne vulgaris," "carbon dioxide," and "fraction* laser(s)" for the period from January 1987 to December 2016...
January 5, 2018: Facial Plastic Surgery: FPS
https://www.readbyqxmd.com/read/29289269/myocardial-infarction-secondary-to-blunt-chest-trauma
#3
Tariq S Marroush, Amreeta V Sharma, Louis D Saravolatz, Robert Takla, Howard S Rosman
Myocardial infarction (MI) following blunt chest trauma is rare, but potentially fatal. We treated a young patient for acute MI after falling chest-first on ice while playing hockey. Coronary artery bypass grafting (CABG) was performed after percutaneous stenting attempts were unsuccessful. By reviewing the related literature, we found 179 cases, the majority of which affected young males following road accidents. Left anterior descending artery was most frequently affected followed by right coronary artery particularly in their proximal thirds...
January 2018: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/29280694/initial-assessment-in-the-management-of-adult-epistaxis-systematic-review
#4
M Khan, K Conroy, K Ubayasiri, J Constable, M E Smith, R J Williams, I Kuhn, M Smith, C Philpott
BACKGROUND: The initial assessment of epistaxis patients commonly includes: first aid measures, observations, focused history taking, and clinical examinations and investigations. This systematic review aimed to identify evidence that informs how the initial assessment of these patients should be conducted. METHOD: A systematic review of the literature was performed using a standardised methodology and search strategy. RESULTS: Seventeen articles were included...
December 2017: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/29279676/comparative-evaluation-of-calcium-phosphate-based-varnish-and-resin-modified-glass-ionomer-based-varnish-in-reducing-dentinal-hypersensitivity-a-randomized-controlled-clinical-trial
#5
Harshul Sharma, Charu Gupta, Sophia Thakur, Sanjeev Srivastava
Objective: The aim of this study was to evaluate the efficacy of MI varnish and Clinpro XT varnish in reducing dentinal hypersensitivity. Materials and Methods: Patients with cervical dentinal hypersensitivity were selected for the study. The teeth to be tested were isolated. Then, a blast of air and ice cold water was applied on the tooth surface, and the score was measured by visual analog scale. The patients were randomly assigned to one of the treatment groups (Group 1: MI varnish; Group 2; Clinpro XT varnish)...
October 2017: European Journal of Dentistry
https://www.readbyqxmd.com/read/29250451/hypokalemic-paralysis-secondary-to-immune-checkpoint-inhibitor-therapy
#6
Pragathi Balakrishna, Augusto Villegas
Introduction of immune checkpoint inhibitors (ICIs) has led to significant improvements in the treatment of multiple malignancies. Anti-programmed cell death protein 1 (PD-1) and anti-cytotoxic T-lymphocyte antigen 4 (CTLA-4) are two essential ICIs that have been FDA approved since 2011. As the use of immunotherapy in melanoma and other malignancies increases, the potential of adverse events also increases. Overall, anti-PD-1 agents are well tolerated. In rare instances, colitis, endocrinopathies, skin, and renal toxicities have been observed...
2017: Case Reports in Oncological Medicine
https://www.readbyqxmd.com/read/29206917/tunicamycin-induced-er-stress-in-breast-cancer-cells-neither-expresses-grp78-on-the-surface-nor-secretes-it-into-the-media
#7
Jesús E Serrano-Negrón, Zhenbo Zhang, Andrea P Rivera-Ruiz, Aditi Banerjee, Eva C Romero-Nutz, Neysharie Sánchez-Torres, Krishna Baksi, Dipak K Banerjee
GRP78 (an Mr 78 kDa calcium dependent glucose binding protein) located in ER lumen. It functions as ER chaperone and translocates proteins for glycosylation at the asparagine residue present in the sequon Asn-X-Ser/Thr. Paraffin sections from N-glycosylation inhibitor tunicamycin treated ER-/PR-/HER2+ (double negative) breast tumor in athymic nude mice exhibited reduced N-glycan but increased GRP78 expression. We have evaluated the effect of tunicamycin on cellular localization of GRP78 in metastatic human breast cancer cells MDA-MB-231 (ER-/PR-/HER2-)...
December 1, 2017: Glycobiology
https://www.readbyqxmd.com/read/29197593/nanoparticle-mediated-cryosurgery-for-tumor-therapy
#8
REVIEW
Yi Hou, Ziqiao Sun, Wei Rao, Jing Liu
Cryosurgery is an energy-based surgical technique. It is minimally invasive and has fewer side effects than surgical resection. However, its insufficient freezing to target tumor and unavoidable injury to healthy tissue have restricted its success. Nano-cryosurgery is the combination of cryogenic biomedicine and nanotechnology. Its principle is to introduce a nanoparticle solution into target tissues to maximize heat transfer, lower the end temperature, increase ice ball formation, and prevent healthy tissues from being frozen...
December 18, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/29178480/hydrogel-encapsulation-facilitates-rapid-cooling-cryopreservation-of-stem-cell-laden-core-shell-microcapsules-as-cell-biomaterial-constructs
#9
Gang Zhao, Xiaoli Liu, Kaixuan Zhu, Xiaoming He
Core-shell structured stem cell microencapsulation in hydrogel has wide applications in tissue engineering, regenerative medicine, and cell-based therapies because it offers an ideal immunoisolative microenvironment for cell delivery and 3D culture. Long-term storage of such microcapsules as cell-biomaterial constructs by cryopreservation is an enabling technology for their wide distribution and ready availability for clinical transplantation. However, most of the existing studies focus on cryopreservation of single cells or cells in microcapsules without a core-shell structure (i...
November 27, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29170340/43%C3%A2-management-of-acute-low-back-pain-in-the-ed-a-systematic-review
#10
Jane Ashbrook, Nikos Rodgdakis, Peter Goodwin, Gill Yeowell, Michael Callaghan
STUDY OBJECTIVE: There is no consensus on the management of low back pain in the ED and evidence suggests that these patients are likely to receive unwarranted imaging and inappropriate opioid prescription.The purpose of this study is to review the available literature pertaining to the clinical management of acute low back pain in the ED. METHODS: The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) and Realist And Meta-narrative Evidence Syntheses: Evolving Standards (RAMESES) guidelines were observed during this review...
December 2017: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/29166187/cognitive-behavioral-and-family-psychoeducational-therapies-for-adolescent-inmates-experiencing-anxiety-in-a-narcotics-correctional-facility
#11
Madepan Mulia, Budi Anna Keliat, Ice Yulia Wardani
Illicit substance use is becoming a major global issue. In Indonesia, inmates imprisoned for illicit substance offences accounted for 40% of the total inmate population. This study aimed to identify the effects of cognitive behavioral and family psychoeducational therapies on inmates' anxiety in the narcotics correctional facility. Quasi-experimental pre-test-post-test with control group was employed in this study. Intervention Group 1 received a general nursing intervention whereas Intervention Group 2 received a combination of general nursing intervention with cognitive behavioral and family psychoeducational therapies...
2017: Comprehensive Child and Adolescent Nursing
https://www.readbyqxmd.com/read/29158727/near-complete-response-in-a-patient-with-classical-hodgkin-lymphoma-treated-with-brentuximab-vedotin-concurrent-with-radiation-therapy
#12
Wilbur Montana, Dennis Andrew Buck, Tristan Smith
Brentuximab vedotin, an antibody drug conjugate that delivers monomethyl auristatin E into CD-30 expressing cells is FDA approved for the treatment of patients with Hodgkin lymphoma after the failure of autologous stem cell transplantation or at least 2 prior multi-agent chemotherapy regiments. This approval was based on a study that showed an overall response rate of 75% and complete remission in 34%. We present a case of a 24-year-old male with classical nodular sclerosing Hodgkin lymphoma who achieved near complete remission following 5 cycles of brentuximab concurrent with ISRT (involved site radiation therapy) following progression of first-line ABVD (Adriamycin, bleomycin, vinblastine, dacarbazine) and subsequent second-line ICE (ifosfamide, carboplatin, etoposide) chemotherapy...
September 2017: Case Reports in Oncology
https://www.readbyqxmd.com/read/29135665/cryoablation-of-bone-metastases-from-renal-cell-carcinoma-for-local-tumor-control
#13
Carly S Gardner, Joe E Ensor, Kamran Ahrar, Steven Y Huang, Sharjeel H Sabir, Nizar M Tannir, Valerae O Lewis, Alda L Tam
BACKGROUND: Patients with bone metastases from renal cell carcinoma often are not surgical candidates and have a poor prognosis. There are limited data on the use of cryoablation as a locoregional therapy for bone metastases. Our objective was to assess the local tumor-control rate following cryoablation of bone metastases in the setting of renal cell carcinoma. METHODS: We retrospectively reviewed the medical records of patients with metastatic renal cell carcinoma who underwent cryoablation for bone metastases between 2007 and 2014...
November 15, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/29117827/tuberculosis-of-the-elbow-region-in-pediatric-age-group-experiences-from-a-single-centre
#14
Anil Agarwal, Anuj Rastogi
BACKGROUND: Clinical series of tuberculosis of elbow region in children are few. The purpose of our study was to retrospectively review the presentation, healing response and functional results of 30 children. METHODS: The pretreatment disease presentation was studied from patient's case records. Serial radiographs of the patients were studied to see remineralization and healing of radiological lesions. For elbow's functional evaluation, pain, range of motion and recurrence were observed at final follow up...
December 2017: Journal of Hand Surgery Asian-Pacific Volume
https://www.readbyqxmd.com/read/29044869/polyproline-is-a-minimal-antifreeze-protein-mimetic-and-enhances-the-cryopreservation-of-cell-monolayers
#15
Ben Graham, Trisha L Bailey, Joseph R J Healey, Moreno Marcellini, Sylvain Deville, Matthew I Gibson
Tissue engineering, gene therapy, drug screening and emerging regenerative medicine therapies are fundamentally reliant on high-quality adherent cell culture, but current methods to cryopreserve cells in this format can give low cell yields and requires large volumes of solvent 'antifreezes'. Herein we report polyproline is a minimum (bio)synthetic mimic of antifreeze proteins, which is accessible by solution, solid phase and recombinant methods. We demonstrate that polyproline has ice recrystallization inhibition activity linked to its amphipathic helix and that it enhances the DMSO- cryopreservation of adherent cell lines...
October 18, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/29020808/acute-hemophilic-hemarthrosis-is-local-cryotherapy-recommended
#16
E Carlos Rodriguez-Merchan, Hortensia de la Corte-Rodriguez
The management of acute hemophilic hemarthrosis (AHH) classically has consisted of factor replacement therapy and RICE (rest, ice, compression and elevation). However, there is still a controversy in the literature regarding the role of local cryotherapy (LC) in AHH. Areas covered: The aim of this article is to review the potential role of LC in AHH. Expert commentary: Some authors have reported that LC attenuates joint inflammation and has a positive influence on controlling articular swelling and temperature...
October 12, 2017: Expert Review of Hematology
https://www.readbyqxmd.com/read/28986000/the-effect-of-light-emitting-diode-590-830%C3%A2-nm-based-low-level-laser-therapy-on-posttraumatic-edema-of-facial-bone-fracture-patients
#17
Woo Yeol Baek, Il Hwan Byun, In Sik Yun, Jae Yoon Kim, Tai Suk Roh, Dae Hyun Lew, Young Seok Kim
PURPOSE: Posttraumatic edema in facial bone fracture patients may interfere with the operation field and delay the schedule. Thus, swiftly reducing the edema alleviates patient discomfort and advances the operation date. Ice packing and compression bandages are often used for such a purpose, but such methods are often inconvenient for the face. In this study, we aim to analyze the effect of light-emitting diode (LED) (590/830 nm)-based low-level laser therapy (LLLT) in posttraumatic edema in facial bone fracture patients...
September 2, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/28984694/cold-induced-dermatoses-case-report-and-review-of-literature
#18
Barbara Saenz Ibarra, Jason Meeker, Omid Jalali, Michael C Lynch
Cold panniculitis and perniosis are the most common cold-induced dermatologic disorders and are clinically characterized by indurated and erythematous nodules and plaques that develop at sites exposed to excessive cold and wet conditions. Cold panniculitis is most commonly seen in infants, but adult cases involving the thighs of equestrians are well known and have come to be known as equestrian cold panniculitis or equestrian perniosis. Recently, similar cases have been described in nonequestrian settings with the prolonged use of ice-packs or other cold-therapy devices...
September 27, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28975429/innovative-intraoral-cooling-device-better-tolerated-and-equally-effective-as-ice-cooling
#19
Java Walladbegi, Martin Gellerstedt, Anncarin Svanberg, Mats Jontell
PURPOSE: Most of the patients who receive myeloablative therapy prior to stem cell transplantation develop oral mucositis (OM). This adverse reaction manifests as oral mucosal erythema and ulcerations and may require high doses of morphine for pain alleviation. OM may also interfere with food intake and result in weight loss, a need for parenteral nutrition, and impaired quality of life. To date, there have been very few studies of evidence-based interventions for the prevention of OM...
November 2017: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/28966905/synergistic-development-of-biochips-and-cell-preservation-methodologies-a-tale-of-converging-technologies
#20
Shangping Wang, Gloria D Elliott
PURPOSE OF THE REVIEW: Over the past several decades, cryopreservation has been widely used to preserve cells during long term storage, but advances in stem cell therapies, regenerative medicine, and miniaturized cell-based diagnostics and sensors are providing new targets of opportunity for advancing preservation methodologies. The advent of microfluidics-based devices is an interesting case in which the technology has been used to improve preservation processing, but as the devices have evolved to also include cells, tissues, and simulated organs as part of the architecture, the biochip itself is a desirable target for preservation...
March 2017: Current Stem Cell Reports
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