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https://www.readbyqxmd.com/read/29777985/liquid-chromatography-tandem-mass-spectrometry-for-the-quantification-of-moxifloxacin-ciprofloxacin-daptomycin-caspofungin-and-isavuconazole-in-human-plasma
#1
Julian Hösl, André Gessner, Nahed El-Najjar
A simple and precise ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method was developed for the simultaneous analysis of five anti-infective agents used to treat severe infections [three antibiotics (daptomycin, moxifloxacin, ciprofloxacin) and two antifungals (isavuconazole, caspofungin)] in human plasma. Sample preparation was based on protein precipitation with ice cold methanol. All five agents were analyzed with the corresponding isotopically labeled internal standards. All analytes were detected in multiple reactions monitoring (MRM) using API 4000 triple-quadrupole mass spectrometer with electrospray (ESI) source operating in positive mode...
May 12, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29742611/falciform-ligament-artery-uptake-on-99mtc-maa-planning-scan-before-90y-sirt-confirmed-by-retrospective-spect-mri-fusion
#2
Nils Große Hokamp, Carsten Kobe, James K O'Donnell, Amit Gupta
Selective internal radiation therapy using Y spheres is a treatment option for patients with primary or secondary liver cancer. To avoid complications, screening using Tc macroaggregated albumin is performed to identify lung shunting and extrahepatic depositions. For the latter, deposition after the anterior abdominal wall is frequently attributed to a patent falciform artery, although the vessel itself is rarely visible on SPECT/CT scans. We demonstrate that retrospective SPECT/MRI fusion clearly attributes the nuclide accumulation to a patent falciform artery...
April 30, 2018: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29729030/treating-pediatric-post-tonsillectomy-pain-and-nausea-with-complementary-and-alternative-medicine
#3
REVIEW
Katherine R Keefe, Kevin J Byrne, Jessica R Levi
OBJECTIVES: Although tonsillectomy is a common and largely safe procedure, pain management in children remains a controversial topic. In addition to the challenge of choosing appropriate analgesia, there is often low parent and child adherence. This article presents a review, and evaluates the potential role, of a range of complementary and alternative therapies that may be sought out by parents. METHODS: A literature review of complementary and alternative interventions performed using PubMed, Cochrane Library, and EMBASE, supplemented by searches from Google and hand searches of cross-references of selected articles, yielded 32 studies for qualitative analysis...
May 4, 2018: Laryngoscope
https://www.readbyqxmd.com/read/29705484/the-combined-effects-of-cold-therapy-and-music-therapy-on-pain-following-chest-tube-removal-among-patients-with-cardiac-bypass-surgery
#4
Sajad Yarahmadi, Nooredin Mohammadi, Arash Ardalan, Hassan Najafizadeh, Mohammad Gholami
BACKGROUND: Chest tube removal is an extremely painful procedure and patients may not respond well to palliative therapies. This study aimed to examine the effect of cold and music therapy individually, as well as a combination of these interventions on reducing pain following chest tube removal. METHODS: A factorial randomized-controlled clinical trial was performed on 180 patients who underwent cardiac surgery. Patients were randomized into four groups of 45. Group A used ice packs for 20 minutes prior to chest tube removal...
May 2018: Complementary Therapies in Clinical Practice
https://www.readbyqxmd.com/read/29698337/cold-panniculitis-after-ice-therapy-for-supraventricular-tachycardia
#5
Laurie Malia, Alicia Wang, Laurie Scheiner, V Matt Laurich
A late preterm infant presenting with supraventricular tachycardia (SVT) was admitted to the pediatric intensive care unit because of poor systolic function seen on echocardiogram. The hospitalization was complicated by multiple breakthrough episodes of SVT requiring ice placed on the face during each repeat episode. The infant was later diagnosed as having cold panniculitis secondary to the application of ice to the face on multiple occasions. In children who are hemodynamically stable during SVT episodes, ice is used as first-line treatment...
April 25, 2018: Pediatric Emergency Care
https://www.readbyqxmd.com/read/29694284/publicly-funded-oral-chronic-hepatitis-b-treatment-patterns-in-ontario-over-16-years-an-ecologic-study
#6
Mina Tadrous, Mayur Brahmania, Diana Martins, Sandra Knowles, Harry L A Janssen, Muhammad M Mamdani, David N Juurlink, Tara Gomes
BACKGROUND: Reimbursement for the use of hepatitis B virus (HBV) treatments has not been previously reported for public payers. OBJECTIVE: To describe the number of users and total cost of HBV treatments over the last 16 years among residents of Ontario, Canada, who were covered by the public drug program. METHODS: We conducted a repeated cross-sectional study for HBV treatments reimbursed by the public drug program in Ontario from January 1, 2000, to December 31, 2015...
May 2018: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/29666764/evaluation-of-a-therapy-for-idiopathic-chronic-enterocolitis-in-rhesus-macaques-macaca-mulatta-and-linked-microbial-community-correlates
#7
Joshua M Taylor, Erik L Clarke, Kate Baker, Abigail Lauder, Dorothy Kim, Aubrey Bailey, Gary D Wu, Ronald G Collman, Lara Doyle-Meyers, Kasi Russell-Lodrigue, James Blanchard, Frederic D Bushman, Rudolf Bohm
Idiopathic chronic enterocolitis (ICE) is one of the most commonly encountered and difficult to manage diseases of captive rhesus macaques ( Macaca mulatta ). The etiology is not well understood, but perturbations in gut microbial communities have been implicated. Here we evaluated the effects of a 14-day course of vancomycin, neomycin, and fluconazole on animals affected with ICE, comparing treated, untreated, and healthy animals. We performed microbiome analysis on duodenal and colonic mucosal samples and feces in order to probe bacterial and/or fungal taxa potentially associated with ICE...
2018: PeerJ
https://www.readbyqxmd.com/read/29663029/yttrium-90-ibritumomab-tiuxetan-zevalin-followed-by-beam-z-beam-conditioning-regimen-and-autologous-stem-cell-transplantation-asct-in-relapsed-or-refractory-high-risk-b-cell-non-hodgkin-lymphoma-nhl-a-single-institution-italian-experience
#8
Chiara Ciochetto, Barbara Botto, Roberto Passera, Marilena Bellò, Giulia Benevolo, Carola Boccomini, Alessia Castellino, Annalisa Chiappella, Roberto Freilone, Maura Nicolosi, Lorella Orsucci, Clara Pecoraro, Patrizia Pregno, Gianni Bisi, Umberto Vitolo
Chemo-refractory NHL has a very poor outcome; the addiction of RIT to salvage regiment pre ASCT had recently demonstrated promising results.We performed a retrospective sequential study to determine the feasibility of standard Zevalin with BEAM in high-risk relapse/refractory NHL. A matched cohort analysis with a group treated with standard BEAM without Zevalin was performed as secondary endpoint. Between October 2006 and January 2013, 37 NHL patients at high risk for progression or early (< 1 year) or multiple relapses were treated with Z-BEAM and ASCT after R-DHAP or R-ICE as salvage therapy...
April 16, 2018: Annals of Hematology
https://www.readbyqxmd.com/read/29662322/a-comparative-trial-of-ice-application-versus-emla-cream-in-alleviation-of-pain-during-botulinum-toxin-injections-for-palmar-hyperhidrosis
#9
Adel Alsantali
Background: Botulinum toxin is a safe and effective therapy for palmar hyperhidrosis, but the associated pain from injections limits the usefulness of this method of treatment. Purpose: To evaluate the efficacy of Eutectic Mixture of Local Anesthetics (EMLA) cream versus ice application in alleviation of pain during botulinum toxin injections for palmar hyperhidrosis. Methods: In this prospective study, 23 patients underwent palm Botox injections to treat their excessive sweating...
2018: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/29650216/the-effectiveness-of-acceptance-and-commitment-therapy-on-anxiety-in-clients-with-stroke
#10
Renta Sianturi, Budi Anna Keliat, Ice Yulia Wardani
OBJECTIVE: The purpose of this study was to determine the effects of acceptance and commitment therapy on anxiety in patients with stroke, especially during the first stage of recovery. METHOD: This quantitative study featured a quasi-experimental design without a control group and was conducted in the stroke ward of a public hospital. The 33 respondents were selected via consecutive sampling. The data analysis was completed using the paired t-test. RESULTS: The use of acceptance and commitment therapy significantly the signs and symptoms of anxiety in patients with stroke (p-value = < 0...
February 2018: Enfermería Clínica
https://www.readbyqxmd.com/read/29650214/acceptance-and-commitment-therapy-and-family-psycho-education-for-clients-with-schizophrenia
#11
Encik Putri Ema Komala, Budi Anna Keliat, Ice Yulia Wardani
OBJECTIVE: This study aims to determine the effectiveness of combining acceptance and commitment therapy with family psycho education on increased insight, diminished symptoms, and the client's improved ability to control violent behavior. METHOD: The design of this study was a quasi-experimental pretest-posttest utilizing intervention and control groups. The intervention group consisted of 33 people, and the control group was composed of 33 people. Data was collected before and after respondents received both acceptance and commitment therapy and family psycho education...
February 2018: Enfermería Clínica
https://www.readbyqxmd.com/read/29629777/using-a-novel-supramolecular-gel-cryopreservation-system-in-microchannel-to-minimize-the-cell-injury
#12
Dong Xu Lan, Xi Chen, Pengcheng Li, Wei Zou, Lili Wu, Wanyu Chen
The storage of living cells is the major challenge for cell research and cell treatment. Here, we introduced a novel supramolecular gel cryopreservation system which was prepared in microchannel and the supramolecular gel (BDTC) was self-assembled by gelator Boc-O-dodecyl-L-tyrosine (BDT). This cryopreservation system could obviously minimize the cell injury because BDTC supramolecular gel had a more compact three-dimensional network structure when BDT gelator self-assembled in the confined space of microchannel...
April 9, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29623179/co-expression-of-myc-and-bcl2-predicts-poorer-outcomes-for-relapsed-refractory-diffuse-large-b-cell-lymphoma-with-r-ice-and-intent-to-transplant
#13
Joshua Allen, Ana Lucia Ruano Mendez, Lisa Rybicki, Yazeed Sawalha, Deepa Jagadeesh, Robert Dean, Brad Pohlman, Mitchell R Smith, Eric D Hsi, Brian T Hill
Diffuse large B-cell lymphoma (DLBCL) with co-expression of MYC and BCL2 protein by immunohistochemistry (IHC) - that is, double-expresser lymphoma (DEL) - is associated with poor outcomes after standard frontline therapy. Less is known about the prognostic impact of DEL in patients with relapsed/refractory disease treated with salvage therapy and autologous stem cell transplantation (ASCT). We analyzed the outcomes of 167 patients with relapsed/refractory DLBCL treated with R-ICE (rituximab, ifosfamide, carboplatin and etoposide), of whom 111 patients (66%) underwent ASCT...
April 2018: Therapeutic Advances in Hematology
https://www.readbyqxmd.com/read/29602140/effect-of-simvastatin-and-ezetimibe-on-supar-levels-and-outcomes
#14
Gethin W Hodges, Casper N Bang, Julie L Forman, Michael H Olsen, Kurt Boman, Simon Ray, Y Antero Kesäniemi, Jesper Eugen-Olsen, Anders M Greve, Jørgen L Jeppesen, Kristian Wachtell
BACKGROUND AND AIMS: Soluble urokinase plasminogen activator receptor (suPAR) is an inflammatory marker associated with cardiovascular disease. Statins lower both low-density lipoprotein (LDL)-cholesterol and C-reactive protein (CRP), resulting in improved outcomes. However, whether lipid-lowering therapy also lowers suPAR levels is unknown. METHODS: We investigated whether treatment with Simvastatin 40 mg and Ezetimibe 10 mg lowered plasma suPAR levels in 1838 patients with mild-moderate, asymptomatic aortic stenosis, included in the Simvastatin and Ezetimibe in Aortic Stenosis (SEAS) study, using a pattern mixture model...
March 16, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29602018/low-dose-caffeine-as-a-salivary-tracer-for-the-determination-of-gastric-water-emptying-in-fed-and-fasted-state-a-mri-validation-study
#15
Maximilian Sager, Philipp Jedamzik, Simon Merdivan, Michael Grimm, Felix Schneider, Marie-Luise Kromrey, Mahmoud Hasan, Stefan Oswald, Jens Kühn, Mirko Koziolek, Werner Weitschies
Improving our knowledge about human gastrointestinal physiology and its impact on oral drug delivery is crucial for the development of new therapies and effective drug delivery systems. The aim of this study was to develop an in vivo tool to determine gastric emptying of water by administration of a caffeine as a tracer substance followed by subsequent saliva caffeine analysis. For this purpose, 35mg of caffeine were given to six healthy volunteers after a 10h overnight together with 240mL of tap water either on a fasted stomach or 30min after the high-caloric, high-fat breakfast recommended for bioavailability/bioequivalence (BA/BE) studies...
March 27, 2018: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/29581740/effects-of-low-level-laser-therapy-following-surgical-extraction-of-the-lower-third-molar-with-objective-measurement-of-swelling-using-a-three-dimensional-system
#16
Mahmut Koparal, Ayse Ozcan Kucuk, Hilal Alan, Fatih Asutay, Mehmet Avci
The aim of the present study was to evaluate and compare the effects of single- and two-dose low-level laser therapy (LLLT) on the postoperative swelling, trismus and pain of patients undergoing extraction of impacted mandibular third molars. In addition, edema was volumetrically measured with a 3dMD face system. A total of 45 patients were randomly divided into three treatment groups (15 patients in each group) as follows: Group 1, receiving routine management with ice application and serving as the control group; Group 2, receiving a single dose of LLLT immediately following surgery; and Group 3, receiving two doses of LLLT, immediately following surgery and on day 2 after surgery...
April 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29563945/excellent-treatment-outcomes-in-children-younger-than-18-months-with-stage-4-mycn-nonamplified-neuroblastoma
#17
Chiwoo Kim, Young Bae Choi, Ji Won Lee, Keon Hee Yoo, Ki Woong Sung, Hong Hoe Koo
Purpose: Although the prognosis is generally good in patients with intermediate-risk neuroblastoma, no consensus has been reached on the ideal treatment regimen. This study analyzed treatment outcomes and toxicities in patients younger than 18 months with stage 4 MYCN nonamplified neuroblastoma. Methods: We retrospectively analyzed 20 patients younger than 18 months newly diagnosed with stage 4 MYCN nonamplified neuroblastoma between January 2009 and December 2015...
February 2018: Korean Journal of Pediatrics
https://www.readbyqxmd.com/read/29562486/modification-of-therapeutic-temperature-range-in-cryotherapy-could-improve-clinical-efficacy-in-tension-type-headache
#18
Won-Jun Meng, Soo-Young Jo, Sang-Heon Lee, Nack-Hwan Kim
BACKGROUND: Cold pack therapy is not used frequently in clinics in spite of its effectiveness in clinical reports. Low compliance due to cold intolerance may be a disturbance factor that hinders patients from using the modality. OBJECTIVE: To demonstrate the improved compliance and clinical efficacy as new devised cold modality with a different composition is applied to target different therapeutic temperature range in tension-type headache (TTH) patients. METHODS: A randomized, controlled, comparative trial involving 53 patients with tension-type headache was conducted...
March 9, 2018: Journal of Back and Musculoskeletal Rehabilitation
https://www.readbyqxmd.com/read/29531247/high-sensitivity-assay-for-monitoring-esr1-mutations-in-circulating-cell-free-dna-of-breast-cancer-patients-receiving-endocrine-therapy
#19
Laura Lupini, Anna Moretti, Cristian Bassi, Alessio Schirone, Massimo Pedriali, Patrizia Querzoli, Roberta Roncarati, Antonio Frassoldati, Massimo Negrini
Approximately 70% of breast cancers (BCs) express estrogen receptor alpha (ERα) and are treated with endocrine therapy. However, the effectiveness of this therapy is limited by innate or acquired resistance in approximately one-third of patients. Activating mutations in the ESR1 gene that encodes ERα promote critical resistance mechanisms. Here, we developed a high sensitivity approach based on enhanced-ice-COLD-PCR for detecting ESR1 mutations. The method produced an enrichment up to 100-fold and allowed the unambiguous detection of ESR1 mutations even when they consisted of only 0...
March 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29522295/on-thin-ice-barriers-to-adoption-of-surveillance-for-patients-with-stage-i-testicular-seminoma-survey-of-us-radiation-oncologists
#20
Aditya Jain, Catherine Degnin, Yiyi Chen, Mike Craycraft, Arthur Hung, Jerry Jaboin, Charles R Thomas, Timur Mitin
PURPOSE: Most men with stage I testicular seminoma are cured with surgery alone, which is a preferred strategy per national guidelines. The current pattern of practice among US radiation oncologists (ROs) is unknown. MATERIALS AND METHODS: We surveyed practicing US ROs via an online questionnaire. Respondent's characteristics, self-rated knowledge, perceived patient compliance rates with observation were analyzed for association with treatment recommendations. RESULTS: We received 353 responses from ROs, of whom 23% considered themselves experts...
March 9, 2018: International Braz J Urol: Official Journal of the Brazilian Society of Urology
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