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https://www.readbyqxmd.com/read/29135665/cryoablation-of-bone-metastases-from-renal-cell-carcinoma-for-local-tumor-control
#1
Carly S Gardner, Joe E Ensor, Kamran Ahrar, Steven Y Huang, Sharjeel H Sabir, Nizar M Tannir, Valerae O Lewis, Alda L Tam
BACKGROUND: Patients with bone metastases from renal cell carcinoma often are not surgical candidates and have a poor prognosis. There are limited data on the use of cryoablation as a locoregional therapy for bone metastases. Our objective was to assess the local tumor-control rate following cryoablation of bone metastases in the setting of renal cell carcinoma. METHODS: We retrospectively reviewed the medical records of patients with metastatic renal cell carcinoma who underwent cryoablation for bone metastases between 2007 and 2014...
November 15, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/29117827/tuberculosis-of-the-elbow-region-in-pediatric-age-group-experiences-from-a-single-centre
#2
Anil Agarwal, Anuj Rastogi
BACKGROUND: Clinical series of tuberculosis of elbow region in children are few. The purpose of our study was to retrospectively review the presentation, healing response and functional results of 30 children. METHODS: The pretreatment disease presentation was studied from patient's case records. Serial radiographs of the patients were studied to see remineralization and healing of radiological lesions. For elbow's functional evaluation, pain, range of motion and recurrence were observed at final follow up...
December 2017: Journal of Hand Surgery Asian-Pacific Volume
https://www.readbyqxmd.com/read/29044869/polyproline-is-a-minimal-antifreeze-protein-mimetic-and-enhances-the-cryopreservation-of-cell-monolayers
#3
Ben Graham, Trisha L Bailey, Joseph R J Healey, Moreno Marcellini, Sylvain Deville, Matthew I Gibson
Tissue engineering, gene therapy, drug screening and emerging regenerative medicine therapies are fundamentally reliant on high-quality adherent cell culture, but current methods to cryopreserve cells in this format can give low cell yields and requires large volumes of solvent 'antifreezes'. Herein we report polyproline is a minimum (bio)synthetic mimic of antifreeze proteins, which is accessible by solution, solid phase and recombinant methods. We demonstrate that polyproline has ice recrystallization inhibition activity linked to its amphipathic helix and that it enhances the DMSO- cryopreservation of adherent cell lines...
October 18, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/29020808/acute-hemophilic-hemarthrosis-is-local-cryotherapy-recommended
#4
E Carlos Rodriguez-Merchan, Hortensia de la Corte-Rodriguez
The management of acute hemophilic hemarthrosis (AHH) classically has consisted of factor replacement therapy and RICE (rest, ice, compression and elevation). However, there is still a controversy in the literature regarding the role of local cryotherapy (LC) in AHH. Areas covered: The aim of this article is to review the potential role of LC in AHH. Expert commentary: Some authors have reported that LC attenuates joint inflammation and has a positive influence on controlling articular swelling and temperature...
October 12, 2017: Expert Review of Hematology
https://www.readbyqxmd.com/read/28986000/the-effect-of-light-emitting-diode-590-830%C3%A2-nm-based-low-level-laser-therapy-on-posttraumatic-edema-of-facial-bone-fracture-patients
#5
Woo Yeol Baek, Il Hwan Byun, In Sik Yun, Jae Yoon Kim, Tai Suk Roh, Dae Hyun Lew, Young Seok Kim
PURPOSE: Posttraumatic edema in facial bone fracture patients may interfere with the operation field and delay the schedule. Thus, swiftly reducing the edema alleviates patient discomfort and advances the operation date. Ice packing and compression bandages are often used for such a purpose, but such methods are often inconvenient for the face. In this study, we aim to analyze the effect of light-emitting diode (LED) (590/830 nm)-based low-level laser therapy (LLLT) in posttraumatic edema in facial bone fracture patients...
September 2, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/28984694/cold-induced-dermatoses-case-report-and-review-of-literature
#6
Barbara Saenz Ibarra, Jason Meeker, Omid Jalali, Michael C Lynch
Cold panniculitis and perniosis are the most common cold-induced dermatologic disorders and are clinically characterized by indurated and erythematous nodules and plaques that develop at sites exposed to excessive cold and wet conditions. Cold panniculitis is most commonly seen in infants, but adult cases involving the thighs of equestrians are well known and have come to be known as equestrian cold panniculitis or equestrian perniosis. Recently, similar cases have been described in nonequestrian settings with the prolonged use of ice-packs or other cold-therapy devices...
September 27, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28975429/innovative-intraoral-cooling-device-better-tolerated-and-equally-effective-as-ice-cooling
#7
Java Walladbegi, Martin Gellerstedt, Anncarin Svanberg, Mats Jontell
PURPOSE: Most of the patients who receive myeloablative therapy prior to stem cell transplantation develop oral mucositis (OM). This adverse reaction manifests as oral mucosal erythema and ulcerations and may require high doses of morphine for pain alleviation. OM may also interfere with food intake and result in weight loss, a need for parenteral nutrition, and impaired quality of life. To date, there have been very few studies of evidence-based interventions for the prevention of OM...
October 3, 2017: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/28966905/synergistic-development-of-biochips-and-cell-preservation-methodologies-a-tale-of-converging-technologies
#8
Shangping Wang, Gloria D Elliott
PURPOSE OF THE REVIEW: Over the past several decades, cryopreservation has been widely used to preserve cells during long term storage, but advances in stem cell therapies, regenerative medicine, and miniaturized cell-based diagnostics and sensors are providing new targets of opportunity for advancing preservation methodologies. The advent of microfluidics-based devices is an interesting case in which the technology has been used to improve preservation processing, but as the devices have evolved to also include cells, tissues, and simulated organs as part of the architecture, the biochip itself is a desirable target for preservation...
March 2017: Current Stem Cell Reports
https://www.readbyqxmd.com/read/28948122/a-case-of-persistent-low-back-pain-in-a-young-female-caused-by-a-trauma-induced-schmorl-s-node-in-the-lumbar-spine-five-vertebra
#9
Kurt M Mohty, Divneet Mandair, Brent Munroe, Deborah Baldemor
Physicians are often faced with managing difficult conditions such as chronic lower back pain. Intervertebral disk herniation typically occurs horizontally, leading to impingement of the spinal cord which can potentially cause radicular symptoms or other spinal cord pathologies; however, disk herniations can also occur vertically and extend through the endplate of an adjacent cranial or caudal vertebra: a phenomenon known as a Schmorl's node. Although Schmorl's nodes can be seen in many asymptomatic individuals, they can be a cause of degenerative disk disease and low back pain...
July 21, 2017: Curēus
https://www.readbyqxmd.com/read/28881149/evaluation-of-the-clinical-effectiveness-in-routine-practice-of-fluocinolone-acetonide-190%C3%A2-%C3%A2%C2%B5g-intravitreal-implant-in-people-with-diabetic-macular-edema
#10
Sarah E Holden, Craig J Currie, David R Owens
OBJECTIVE: The aim of the Iluvien Clinical Evidence study in the UK (ICE-UK) was to assess the real-world effectiveness of fluocinolone acetonide (FAc) 190 µg intravitreal implant for the treatment of clinically significant chronic diabetic macular edema (DME) in routine clinical practice. METHODS: This retrospective study collected data from patient medical records in 13 ophthalmology centers for people with DME prescribed FAc intravitreal implant between April 1, 2013 and April 15, 2015...
October 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28881146/health-economic-evaluation-of-fluocinolone-acetonide-190%C3%A2-%C3%A2%C2%B5g-implant-in-people-with-diabetic-macular-edema
#11
Sarah E Holden, Craig J Currie, David R Owens
OBJECTIVES: To assess healthcare resource use and costs of treating people with clinically significant diabetic macular edema (DME) with fluocinolone acetonide (FAc) 190 µg intravitreal implant in routine clinical practice. METHODS: The retrospective Iluvien Clinical Evidence (ICE-UK) study collected data on people prescribed the FAc implant in any one of 13 ophthalmology centers between April 1, 2013 and April 15, 2015. Data were collected for 12 months before and after implantation...
October 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28874066/the-role-of-the-accessory-malleolar-ossicles-and-malleolar-avulsion-fractures-in-lateral-ankle-ligament-reconstruction
#12
Matthew M Reiner, Jonathan J Sharpe
While it is well known that ankle sprains are one of the most common injuries in the United States, predictive factors regarding failure of conservative treatment are not well known. There are many biomechanical and epidemiological factors that play a role in recurrence and failure of conservative treatment, but most cases are able to be treated with immobilization and/or rest, ice, elevation, physical therapy, and bracing. We propose that one important risk factor is often overlooked simply due to the fact that a vast majority of these cases resolve without the need for surgery...
September 1, 2017: Foot & Ankle Specialist
https://www.readbyqxmd.com/read/28864405/ischemic-cardiac-events-following-treatment-of-the-internal-mammary-nodal-region-using-contemporary-radiation-planning-techniques
#13
Robert T Dess, Adam L Liss, Kent A Griffith, Robin B Marsh, Jean M Moran, Charles Mayo, Todd M Koelling, Reshma Jagsi, James A Hayman, Lori J Pierce
PURPOSE: Regional nodal irradiation, including radiation therapy (RT) to the internal mammary node (IMN) region, improves oncologic outcomes in patients with node-positive breast cancer. Concern remains, however, given the proximity of the IMNs to the heart and the association between cardiac RT exposure and toxicity. The objective of the study was to evaluate rates of ischemic cardiac events (ICEs) and associated risk with treatment of the IMN region. METHODS AND MATERIALS: The cardiac outcomes of 2126 patients treated with adjuvant breast RT or breast and nodal RT from 1984 to 2007 at a single institution were reviewed...
June 27, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28792260/phase-i-and-randomized-phase-ii-trial-of-panobinostat-in-combination-with-ice-ifosfamide-carboplatin-etoposide-in-relapsed-or-refractory-classical-hodgkin-lymphoma
#14
Bei Hu, Anas Younes, Jason R Westin, Francesco Turturro, Linda Claret, Lei Feng, Nathan Fowler, Sattva Neelapu, Jorge Romaguera, Fredrick B Hagemeister, Maria Alma Rodriguez, Felipe Samaniego, Luis E Fayad, Amanda R Copeland, Loretta J Nastoupil, Yago Nieto, Michelle A Fanale, Yasuhiro Oki
This phase-I/phase-II study evaluated panobinostat in combination with ifosfamide, carboplatin, etoposide (P-ICE) in relapsed/refractory classical Hodgkin lymphoma. During phase I, panobinostat was given daily on Monday/Wednesday/Friday starting one week prior to Cycle 1 (C1) of ICE and during two weeks of C1-2 of ICE (Schedule A). No DLT was observed at 30 mg. However, frequent (84%) grade-4 thrombocytopenia during second week prompted us to omit the second week of panobinostat 30 mg (Schedule B) for phase II, where this regimen was compared to ICE...
August 9, 2017: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/28783479/determination-of-dielectric-properties-of-cryoprotective-agent-solutions-with-a-resonant-cavity-for-the-electromagnetic-rewarming-in-cryopreservation
#15
Jiaji Pan, Zhiquan Shu, Shen Ren, Dayong Gao
In the rewarming process during cryopreservation, preventing ice recrystallization and thermal stress is important, especially for large tissues and organs. Uniform and rapid heating is essential in ameliorating the problem and maintaining the viability of cryopreserved biological samples. Currently, the most promising method is heating by application of electromagnetic (EM) waves, the effectiveness of which is dependent on the dielectric properties (DP) of the cryopreserved materials. In this work, the cavity perturbation method was adopted to measure the DP of cryoprotectant solutions...
August 7, 2017: Biopreservation and Biobanking
https://www.readbyqxmd.com/read/28767169/urodynamic-and-molecular-characteristics-of-detrusor-underactivity-in-a-rat-cryoinjury-model-and-effects-of-low-energy-shock-wave-therapy
#16
Yao-Chi Chuang, Pradeep Tyagi, Hung-Jen Wang, Chao-Cheng Huang, Chih-Chieh Lin, Michael B Chancellor
AIMS: Low energy shock wave (LESW) has been shown to facilitate tissue regeneration and reduce inflammation. We investigated the effects of LESW in an underactive (DU) model induced by cryoinjury of rat detrusor. METHODS: Forty-six female Sprague-Dawley rats were divided into sham, cryoinjury with or without LESW (0.12 mJ/mm(2) ; 200 pulses). Under halothane anesthesia, a low midline incision was made and a cryoinjury of detrusor was induced by placing an aluminum rod (chilled with dry ice) for 30 s on the serosal side of the bladder filled with 1 mL sterile saline bilaterally...
August 2, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28760093/fracture-of-the-lateral-process-of-the-talus
#17
Jennifer Bell, Maggie Warren, Samuel Cotnoir
A 24-year-old woman fell while ice climbing and landed on her left foot. Radiographs were taken and read as noncontributory. Eight days after the injury, the patient was still unable to bear weight due to significant pain, so she self-referred to physical therapy. Following evaluation, she was referred to primary care for further imaging to rule out fracture. The physician ordered magnetic resonance imaging, which revealed a left mildly displaced fracture of the intra-articular lateral process of the talus...
August 2017: Journal of Orthopaedic and Sports Physical Therapy
https://www.readbyqxmd.com/read/28741118/strategies-to-decrease-injection-site-pain-in-botulinum-toxin-therapy
#18
Lejla Paracka, Katja Kollewe, Florian Wegner, Dirk Dressler
Botulinum toxin is now used for numerous indications including dystonias, spasticity, cerebral palsy, hyperhidrosis, cosmetics and chronic migraine. It has to be injected into its target tissues thus causing injection site pain. We wanted to compare the efficacy of various analgesic interventions suggested for reduction of injection site pain. In 13 healthy controls, pain thresholds in the fingertips II and III bilaterally were determined by the Mechanical Pain Threshold Test and the Repetitive Pain Stimulation Test at baseline and under nitrous oxide/oxygen, ice spray, local anaesthetic cream and forearm ischaemia...
October 2017: Journal of Neural Transmission
https://www.readbyqxmd.com/read/28725432/transplanters-drive-cars-to-the-clinic-by-brewing-ice-t-the-moffitt-roadmap
#19
EDITORIAL
Frederick L Locke, Claudio Anasetti
Recent single institution clinical trial successes with anti-CD19 Chimeric Antigen Receptor (CAR) T cell therapy for B cell malignancies attracted significant attention from industry. Our center sought to rapidly and safely bring industry sponsored pivotal trials to our patients and to prepare for additional cell therapy trials in solid and liquid tumors from both industry and our own investigators. We implemented a collaborative cross departmental program to provide clinical care and trial coordination for immune cell therapies...
2017: Journal for Immunotherapy of Cancer
https://www.readbyqxmd.com/read/28716155/transplanters-drive-cars-to-the-clinic-by-brewing-ice-t-the-moffitt-roadmap
#20
EDITORIAL
Frederick L Locke, Claudio Anasetti
Recent single institution clinical trial successes with anti-CD19 Chimeric Antigen Receptor (CAR) T cell therapy for B cell malignancies attracted significant attention from industry. Our center sought to rapidly and safely bring industry sponsored pivotal trials to our patients and to prepare for additional cell therapy trials in solid and liquid tumors from both industry and our own investigators. We implemented a collaborative cross departmental program to provide clinical care and trial coordination for immune cell therapies...
July 18, 2017: Journal for Immunotherapy of Cancer
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