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https://www.readbyqxmd.com/read/27906795/factors-determining-the-outcome-of-hematopoietic-stem-cell-transplantation-in-patients-with-acute-lymphoblastic-leukemia-at-king-faisal-specialist-hospital-and-research-center-riyadh-saudi-arabia
#1
Suleimman Al-Sweedan, Amal Al-Seraihy, Ali Al-Ahmari, Abdullah Al-Jefri, Viqaruddin Mohammed, Rafat Jafri, Khawar Siddiqui, Mouhab Ayas
Medical records of 82 patients with acute lymphoblastic leukemia (ALL) who underwent hematopoietic cell transplantation (HCT) at our institution from 2005 to 2011 were reviewed. Forty-five patients were male (54.8%). The median age at HCT was 7.46 years (range, 0.98 to 14.31 y), the median time to HCT after diagnosis was 12.56 months. Ten patients were below the age of 1 year (12%). All patients were in complete remission at the time of HCT. In 83 transplants, 64 patients received HCT from human leukocyte antigen-identical-related donors and 19 from other donors...
November 30, 2016: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/27672068/centrilobular-nodules-in-high-resolution-computed-tomography-of-the-lung-in-ipah-patients-preliminary-data-concerning-clinico-radiological-correlates
#2
Monika Szturmowicz, Aneta Kacprzak, Barbara Burakowska, Agnieszka Skoczylas, Iwona Bestry, Jan Kuś, Anna Fijałkowska, Adam Torbicki, Marcin Kurzyna
INTRODUCTION: Inhomogeneity of lung attenuation pattern is observed in high resolution chest computed tomography (HRCT) in some IPAH patients despite lack of interstitial lung disease. Such radiological changes are described either as ill-defined centrilobular nodules (CN) or as focal ground glass opacities (FGGO). There is no consensus in the literature, whether they indicate the distinct type of IPAH, or pulmonary venoocclusive disease (PVOD) with subtle radiological changes. Thus the aim of the present pilot study was to assess the frequency and clinical significance of inhomogenic lung attenuation pattern in IPAH...
2016: Pneumonologia i Alergologia Polska
https://www.readbyqxmd.com/read/27659877/physiological-mechanisms-of-pulmonary-hypertension
#3
REVIEW
David H MacIver, Ismail Adeniran, Iain R MacIver, Alistair Revell, Henggui Zhang
Pulmonary hypertension is usually related to obstruction of pulmonary blood flow at the level of the pulmonary arteries (eg, pulmonary embolus), pulmonary arterioles (idiopathic pulmonary hypertension), pulmonary veins (pulmonary venoocclusive disease) or mitral valve (mitral stenosis and regurgitation). Pulmonary hypertension is also observed in heart failure due to left ventricle myocardial diseases regardless of the ejection fraction. Pulmonary hypertension is often regarded as a passive response to the obstruction to pulmonary flow...
October 2016: American Heart Journal
https://www.readbyqxmd.com/read/27623416/small-sample-lung-biopsy-findings-in-patients-with-clinicoradiologic-suspicion-of-pulmonary-venoocclusive-disease-pulmonary-capillary-hemangiomatosis
#4
Shakti K Bal, Balamugesh Thangakunam, Aparna Irodi, Mayank Gupta, Devasahayam J Christopher
Pulmonary venoocclusive disease (PVOD) and pulmonary capillary hemangiomatosis (PCH) form a sinister subgroup of pulmonary arterial hypertension where the predominant pathology lies in the pulmonary veins and capillaries, thus making the use of pulmonary vasodilators potentially dangerous in these patients. Radiologically, the presence of centrilobular nodules, interlobular septal thickening, and significant mediastinal adenopathy are useful in identifying this subgroup from patients with pulmonary arterial hypertension...
October 2016: Journal of Bronchology & Interventional Pulmonology
https://www.readbyqxmd.com/read/27499838/refractory-ascites-with-liver-fibrosis-developed-in-late-phase-allogeneic-hematopoietic-stem-cell-transplantation-report-of-three-patients
#5
Hiroki Hosoi, Kenji Warigaya, Shogo Murata, Toshiki Mushino, Kodai Kuriyama, Akinori Nishikawa, Shinobu Tamura, Kazuo Hatanaka, Nobuyoshi Hanaoka, Yasuteru Muragaki, Shinichi Murata, Hideki Nakakuma, Takashi Sonoki
We report cases of three patients of refractory ascites without other fluid retention that occurred around five months after allogeneic hematopoietic stem cell transplantation (allo-HSCT). All three patients expired and postmortem examinations revealed unexpected liver fibrosis lacking histological evidences of graft-versus-host-disease (GVHD). The three patients showed normal hepatic function and size before transplantation. During their clinical courses, serum biochemistry test showed no elevation of hepatic enzymes and bilirubin; however, imaging studies demonstrated hepatic atrophy at the onset of ascites...
May 10, 2016: Hematology Reports
https://www.readbyqxmd.com/read/25722722/hematopoietic-stem-cell-transplantation-in-the-developing-world-experience-from-a-center-in-western-india
#6
Chirag A Shah, Arun Karanwal, Maharshi Desai, Munjal Pandya, Ravish Shah, Rutvij Shah
We describe our experience of first 50 consecutive hematopoietic stem-cell transplants (HSCT) done between 2007 and 2012 at the Apollo Hospital, Gandhinagar, 35 autologous HSCT and 15 allogeneic HSCT. Indications for autologous transplant were multiple myeloma, non-Hodgkin lymphoma, Hodgkin lymphoma, and acute myeloid leukemia, and indications for allogeneic transplants were thalassemia major, aplastic anaemia, chronic myeloid leukemia, and acute lymphoblastic and myeloid leukaemia. The median age of autologous and allogeneic patient's cohort was 50 years and 21 years, respectively...
2015: Journal of Oncology
https://www.readbyqxmd.com/read/25611112/pulmonary-capillary-hemangiomatosis-a-rare-cause-of-pulmonary-hypertension
#7
REVIEW
Mary C O'Keefe, Miriam D Post
Pulmonary capillary hemangiomatosis is a rare cause of pulmonary hypertension characterized by extensive proliferation of pulmonary capillaries within alveolar septae. Clinical presentation is nonspecific and includes dyspnea, cough, chest pain, and fatigue. Radiology shows diffuse centrilobular ground-glass opacities. Pulmonary capillary hemangiomatosis is clinically and radiographically indistinguishable from peripheral venoocclusive disease, making microscopic diagnosis essential. Histologically, pulmonary capillary hemangiomatosis shows an abnormal proliferation of small, thin-walled capillaries that expand the alveolar septae...
February 2015: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/25477970/mesenteric-inflammatory-venoocclusive-disease-in-a-patient-with-sj%C3%A3-gren-s-syndrome
#8
Raquel Rios-Fernández, José-Luis Callejas-Rubio, Mercedes Caba-Molina, Rosa Ríos-Peregrina, Norberto Ortego-Centeno
Mesenteric inflammatory venoocclusive disease is an uncommon cause of intestinal ischemia. Certain diseases, such as hypercoagulation disorders, autoimmune diseases, or drugs have been associated with the pathogenesis of mesenteric inflammatory venoocclusive disease. Here, we report a patient with Sjögren's syndrome who underwent surgery for suspected acute appendicitis with a subsequent pathological diagnosis of mesenteric inflammatory venoocclusive disease.
2014: Case Reports in Medicine
https://www.readbyqxmd.com/read/25105933/hematopoietic-stem-cell-transplantation-graft-versus-host-disease-and-pathology-of-gastrointestinal-tract-liver-and-lung
#9
REVIEW
Neeraja Kambham, John P Higgins, Uma Sundram, Megan L Troxell
Hematopoietic stem cell transplantation (HCT), formerly known as bone marrow transplantation, is an integral part of treatment for many hematological malignancies. HCT is associated with several complications and comorbidities with differential effects on a wide spectrum of organs and tissues. We present an update on HCT-associated complications such as graft versus host disease (GVHD) and infection, with focus on the surgical pathology of the gastrointestinal (GI) tract, liver, and lung. Although the grading system for GI tract acute GVHD was proposed 40 years ago, recent studies have shed light on minimal histologic criteria for diagnosis of GVHD, as well as its differential diagnosis, including histologic effects of various medications...
September 2014: Advances in Anatomic Pathology
https://www.readbyqxmd.com/read/25027536/visual-compatibility-of-defibrotide-with-selected-drugs-during-simulated-y-site-administration
#10
Florian Correard, Amandine Savry, Laurence Gauthier-Villano, Pascale Pisano, Bertrand Pourroy
PURPOSE: The visual compatibility of a solution of defibrotide (the only drug recommended for treatment and prophylaxis of hepatic venoocclusive disease) with solutions of various drugs commonly administered in bone marrow transplant procedures was studied. METHODS: Solutions of 43 drug products in concentrations typically used in clinical practice were evaluated in 1:1 mixtures with defibrotide solution in glass tubes kept at room temperature. The evaluated products included antiinfectious, corticoid, sedative, analgesic, and cardiovascular agents widely used for hematopoietic stem cell transplantation and other marrow transplant procedures; in most cases, test solutions were prepared via dilution in or reconstitution with sterile water, 0...
August 1, 2014: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/23699237/alveolar-hemorrhage-secondary-to-sarcoidosis-associated-pulmonary-venoocclusive-disease-pvod
#11
Jose Soto Soto, Andras Khoor, Augustine Lee
SESSION TYPE: ILD Cases IIPRESENTED ON: Tuesday, October 23, 2012 at 11:15 AM - 12:30 PMINTRODUCTION: Hemoptysis is uncommon in patients with sarcoidosis. Recent literature suggests an association between PVOD like changes and sarcoidosis in patients with recurrent hemoptysis.CASE PRESENTATION: A 50-year-old female presented with a 4-year history of recurrent hemoptysis and dyspnea on exertion. Her medical history included iron-deficiency anemia of unknown etiology, an indeterminate interstitial lung disease, and recurrent painless rash in the lower extremities...
October 1, 2012: Chest
https://www.readbyqxmd.com/read/23664600/hematopoietic-stem-cell-transplantation-practice-variation-among-centers-in-the-eastern-mediterranean-region-emro-eastern-mediterranean-bone-marrow-transplantation-embmt-group-survey
#12
Walid Rasheed, Ardeshir Ghavamzadeh, Rosemarie Hamladji, Tarek Ben Othman, Amal Alseraihy, Fawzi Abdel-Rahman, Alaa Elhaddad, Abdulaziz Alabdulaaly, David Dennison, Ahmad Ibrahim, Ali Bazarbachi, Mohamed-Amine Bekadja, Said Yousuf Mohamed, Salman Naseem Adil, Parvez Ahmed, Said Benchekroun, Mani Ramzi, Mohammad Jarrar, Kamran Alimoghaddam, Fazal Hussain, Amir Hamidieh, Mahmoud Aljurf
INTRODUCTION: This practice survey is conducted to analyze clinical hematopoietic stem cell transplantation (HSCT) practice variability among centers in the WHO Eastern Mediterranean Region (EMRO), as represented by the Eastern Mediterranean Blood and Marrow Transplantation (EMBMT) group. METHOD: This internet based survey was completed by the medical program directors of the EMBMT centers; 17 centers participated. The survey collected data on various clinical aspects of HSCT practice...
March 2013: Hematology/oncology and Stem Cell Therapy
https://www.readbyqxmd.com/read/23580820/stem-cell-transplant-an-experience-from-eastern-india
#13
A Mukhopadhyay, P Gupta, J Basak, A Chakraborty, D Bhattacharyya, S Mukhopadhyay, U K Roy
BACKGROUND: Hematopoietic stem cell transplant using human leukocyte antigen (HLA)-matched sibling or unrelated bone marrow, or related or unrelated cord blood has been performed successfully to treat patients with different types of hematological malignancies, genetic disorders and hereditary immune deficiencies. Since 1983, stem cell transplantation has been carried out in different institutes of India. But, till then, no transplantation was performed in eastern India. MATERIALS AND METHODS: Our present study is reporting for the first time stem cell transplantation in eastern India...
October 2012: Indian Journal of Medical and Paediatric Oncology
https://www.readbyqxmd.com/read/23352326/postradiofrequency-ablation-inflammatory-pseudotumor-associated-with-pulmonary-venoocclusive-disease-case-report-and-review-of-the-literature
#14
REVIEW
Alexandra E Kovach, George Z Cheng, Colleen L Channick, Richard N Channick, Ashok Muniappan, Henning A Gaissert, Richard L Kradin
Radiofrequency ablation of pulmonary veins is a common therapeutic intervention for atrial fibrillation. Pulmonary vein stenosis and venoocclusive disease are recognized complications, but the spectrum of pathologies postablation have not been previously reviewed. A recent case at our hospital showed a left hilar soft tissue mass in association with superior pulmonary vein stenosis in a patient 4 years postablation. On resection, this proved to be an inflammatory pseudotumor composed of myofibroblasts in an organizing pneumonia-type pattern with adjacent dendriform ossifications...
October 2013: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/23336879/single-lobe-lung-transplantation-for-rapidly-deteriorating-pulmonary-venoocclusive-disease
#15
Koji Takahashi, Fengshi Chen, Tadashi Ikeda, Hiraku Doi, Hideaki Nakamura, Sadamitsu Yanagi, Masaaki Sato, Akihiro Aoyama, Toru Bando, Hiroshi Date
Pulmonary venoocclusive disease, classified as a subgroup of pulmonary arterial hypertension, is known to show poor prognosis and lung transplantation is the only possible treatment. Single living-donor lobar lung transplantation is a unique method of treatment, mostly for small children, and size matching is the most important factor to conduct single living-donor lobar lung transplantation safely. We report a successful single living-donor lobar lung transplantation for a 6-year-old girl with pulmonary venoocclusive disease who received the graft from her mother...
February 2013: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/23313065/feasibility-of-allografting-in-patients-with-advanced-acute-lymphoblastic-leukemia-after-salvage-therapy-with-inotuzumab-ozogamicin
#16
Partow Kebriaei, Kaci Wilhelm, Farhad Ravandi, Mark Brandt, Marcos de Lima, Stefan Ciurea, Laura Worth, Susan O'Brien, Deborah Thomas, Richard E Champlin, Hagop Kantarjian
BACKGROUND: No highly effective salvage therapy exists for patients with relapsed acute lymphoblastic leukemia (ALL). Inotuzumab ozogamicin (IO) is a CD22 monoclonal antibody attached to calicheamycin that targets B lymphocytes in early stages of development, successfully inducing remission in patients with multiply relapsed ALL. METHODS: We describe our findings in 26 patients who received allogeneic hematopoietic stem cell transplantation (SCT) after treatment with IO between September 2010 and October 2011...
June 2013: Clinical Lymphoma, Myeloma & Leukemia
https://www.readbyqxmd.com/read/23276886/clofarabine-does-not-negatively-impact-the-outcomes-of-patients-with-acute-myeloid-leukemia-undergoing-allogeneic-stem-cell-transplantation
#17
Michael S Mathisen, Hagop Kantarjian, Elias Jabbour, Guillermo Garcia-Manero, Farhad Ravandi, Stefan Faderl, Gautam Borthakur, Jorge E Cortes, Alfonso Quintás-Cardama
UNLABELLED: We evaluated whether clofarabine-containing chemotherapy predisposed patients to hepatic toxicity (particularly venoocclusive disease [VOD]) after allogeneic stem cell transplantation (allo-SCT). In the group who received clofarabine and subsequent transplantation, there were no cases of VOD, and liver toxicity was comparable to a control group who received standard acute myeloid leukemia (AML) chemotherapy. Other transplant-specific outcomes, including overall survival (OS), were also similar when compared with the control group...
April 2013: Clinical Lymphoma, Myeloma & Leukemia
https://www.readbyqxmd.com/read/23200125/safety-and-utility-of-transjugular-liver-biopsy-in-hematopoietic-stem-cell-transplant-recipients
#18
Bela Kis, Vishwan Pamarthi, Chieh-Min Fan, Dmitry Rabkin, Richard A Baum
PURPOSE: Hematopoietic stem cell transplant (HSCT) recipients are at high risk in the setting of percutaneous liver biopsy as a result of comorbid coagulopathy and ascites, and are commonly referred to undergo transjugular liver biopsy. The present study was performed to assess the safety and utility of transjugular liver biopsy in HSCT recipients and to analyze the correlation between corrected hepatic sinusoidal pressure gradient (CHSPG) and pathologic diagnoses. MATERIALS AND METHODS: Data from reports of transjugular liver biopsy procedures, pathology reports, and laboratory values of 141 consecutive HSCT recipients who underwent transjugular liver biopsy with pressure measurement between January 2005 and August 2011 in a single institution were retrospectively reviewed and analyzed...
January 2013: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/23131490/allogeneic-hematopoietic-cell-transplantation-for-xiap-deficiency-an-international-survey-reveals-poor-outcomes
#19
Rebecca A Marsh, Kanchan Rao, Prakash Satwani, Kai Lehmberg, Ingo Müller, Dandan Li, Mi-Ok Kim, Alain Fischer, Sylvain Latour, Petr Sedlacek, Vincent Barlogis, Kazuko Hamamoto, Hirokazu Kanegane, Sam Milanovich, David A Margolis, David Dimmock, James Casper, Dorothea N Douglas, Persis J Amrolia, Paul Veys, Ashish R Kumar, Michael B Jordan, Jack J Bleesing, Alexandra H Filipovich
There have been no studies on patient outcome after allogeneic hematopoietic cell transplantation (HCT) in patients with X-linked inhibitor of apoptosis (XIAP) deficiency. To estimate the success of HCT, we conducted an international survey of transplantation outcomes. Data were reported for 19 patients. Seven patients received busulfan-containing myeloablative conditioning (MAC) regimens. Eleven patients underwent reduced intensity conditioning (RIC) regimens predominantly consisting of alemtuzumab, fludarabine, and melphalan...
February 7, 2013: Blood
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