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Human immunodefiency syndrome

Liliam Cristiana Júlio Tonnera, Betina Hörner Schlindwein Meirelles
OBJECTIVE: to understand the strengths and weaknesses in the care network of people with HIV/AIDS in a referral center in the state of Santa Catarina-SC. METHOD: participants were eight subjects and their care network, totaling 18 participants. Data were collected through interviews and examined by content analysis, theoretically supported by symbolic interaction. RESULTS: the analysis resulted in the following categories: The network offering care to people with acquired immunodeficiency syndrome, and Facing Barriers in care, which reflect the strengths and weaknesses in the care network...
May 2015: Revista Brasileira de Enfermagem
Jeffery M Klco, Bob Geng, Elizabeth M Brunt, Anjum Hassan, Tu-Dung Nguyen, Friederike H Kreisel, Mauricio Lisker-Melman, John L Frater
Patients with hepatitis C virus (HCV) infection develop a number of hematologic disorders, with benign and malignant B-cell proliferations being the most common. HCV-infected patients are also prone to developing peripheral cytopenias, the etiologies of which are multifactorial and include hypersplenism and/or antiviral medications. Some of these patients may undergo bone marrow biopsy but no study has systematically recorded the bone marrow findings in this patient group. Here, we report on the range of bone marrow findings in 47 adult HCV-infected patients...
February 2010: American Journal of Hematology
Rebecca A Dillingham, Relana Pinkerton, Paul Leger, Patrice Severe, Richard L Guerrant, J William Pape, Daniel W Fitzgerald
This case-control study examines whether chronic diarrhea at initiation of antiretroviral therapy (ART) affects survival of human immunodefiency virus-infected patients. Cases (288) were treatment-naive, non-pregnant, adults with self report of frequent loose stool for > 3 weeks at the time ART was initiated. One-third of patients had an enteric pathogen identified including Cryptosporidium spp., Giardia spp., Isospora belli, Cyclospora cayetanensis, and Entamoeba histolytica. Control patients (400) did not have diarrhea when initiating ART...
June 2009: American Journal of Tropical Medicine and Hygiene
Martha Mondiwa, Yvonne Hauck
In this study, Malawian midwives' perceptions of occupational risk of human immunodefiency virus (HIV) infection are described. Knowledge of perceptions of HIV risk in developing countries and consequences on patient care is limited. A qualitative approach using purposive sampling was undertaken with 7 midwives. Participants considered their occupational risk to be high, encompassing these four themes: exposure to body fluids, availability of resources, hand washing practices, and support from management. Additional themes related to the impact of high risk on clinical practice: working in a climate of fear, refraining from touch, loss of interest in midwifery, and improvising care practices...
March 2007: Health Care for Women International
Bruce R Schackman, Kelly A Gebo, Rochelle P Walensky, Elena Losina, Tammy Muccio, Paul E Sax, Milton C Weinstein, George R Seage, Richard D Moore, Kenneth A Freedberg
OBJECTIVE: We sought to project the lifetime cost of medical care for human immunodefiency virus (HIV)-infected adults using current antiretroviral therapy (ART) standards. METHODS: Medical visits and hospitalizations for any reason were from the HIV Research Network, a consortium of high-volume HIV primary care sites. HIV treatment drug regimen efficacies were from clinical guidelines and published sources; data on other drugs used were not available. In a computer simulation model, we projected HIV medical care costs in 2004 U...
November 2006: Medical Care
Kengo Tsuneyoshi, Misako Haraguchi, Zhao Hongye, Takenari Gotanda, Tokushi Tachiwada, Tomoyuki Sumizawa, Tatsuhiko Furukawa, Masanori Baba, Shin-Ichi Akiyama, Masayuki Nakagawa
Thymidine phosphorylase (TP) regulates intracellular thymidine metabolism and can enhance the anti-tumor effectiveness of 5'-deoxy-5-fluorouridine (5'-DFUR) by conversion of the pro-drug 5'-DFUR to 5-fluorouracil (5-FU) in tumor tissues. 5'-DFUR is an effective anti-tumor drug in cells expressing high levels of TP. 3'-Azido 3'-deoxythymidine (AZT) is a thymidine analog that has been proven useful in the treatment of acquired immunodefiency syndrome (AIDS). In this study, we found that AZT induces TP expression and enhances the sensitivity of human myeloid leukemia U937 cells to 5'-DFUR...
December 8, 2006: Cancer Letters
M J Rico
There are currently over 34 million people worldwide infected with human immunodeficiency virus (HIV) with 15,000 new patients infected each day. The acquired immunodefiency syndrome (AIDS) pandemic has particularly affected the third world and currently over 70% of those infected reside in sub-Saharan Africa. The epicenter of the pandemic is shifting to Asia as HIV infection increases in the densely populated countries of India, China, and SE Asia. Patients with HIV infection develop a variety of mucocutaneous diseases and often present to dermatologists...
November 2001: Journal of Dermatology
D V Surbek, W Holzgreve, K H Nicolaides
Allogeneic haematopoietic stem cell transplantation in utero has been successfully used for the prenatal treatment of severe combined immunodefiency syndrome. However, this treatment has not been successful in the therapy of other conditions in which the fetus is immunologically competent. The main obstacles to success are lack of competitive advantage of donor versus host stem cells, preventing stable engraftment and graft rejection. Several strategies are being explored to overcome these problems, and some of them have been successful in animal studies...
January 2001: Human Reproduction Update
L L Glenn, P W Ramsey
Previous studies have suggested that health care workers may differ with respect to universal precautions knowledge, compliance, practice setting barriers, or exposure to patient body fluids in rural and urban areas. The purpose of this study was to determine whether or not there are rural/urban differences in the degree of precaution taken by health care workers to prevent the spread of blood borne pathogens, specifically human immunodeficiency virus (HIV) and hepatitis B virus (HBV). A random sample of rural and urban registered and licensed practical nurses in Tennessee was surveyed...
1995: Journal of Rural Health
A A Brink, D F Dukers, A J van den Brule, J J Oudejans, J M Middeldorp, C J Meijer, M Jiwa
AIMS: To investigate the expression pattern of Epstein-Barr virus (EBV) latent genes at the single cell level in post-transplantation lymphoproliferative disorders and acquired immunodefiency syndrome (AIDS) related lymphomas, in relation to cellular morphology. METHODS: Nine post-transplantation lymphoproliferative disorders and three AIDS related lymphomas were subjected to immunohistochemistry using monoclonal antibodies specific for EBV nuclear antigen 1 (EBNA1) (2H4), EBNA2 (PE2 and the new rat anti-EBNA2 monoclonal antibodies 1E6, R3, and 3E9), and LMP1 (CS1-4 and S12)...
November 1997: Journal of Clinical Pathology
S García, A Combalía, A Serra, J M Segur, R Ramón
Tuberculosis continues to occur frequently in some underdeveloped regions. Bone and joint tuberculosis is less common than the pulmonary form. Fourteen cases of bone and joint tuberculosis in unusual locations are presented. Tuberculostatic treatment and surgical approach were associated in all the patients. In 6 cases an arthrodesis of the affected joint was carried out. A surgical debridement was done in 6 patients and a needle biopsy in 2 patients in order to obtain samples for pathology and bacteriology...
1997: Archives of Orthopaedic and Trauma Surgery
A Valenzuela, J Blanco, C Callebaut, E Jacotot, C Lluis, A G Hovanessian, R Franco
CD26, known to be the adenosine deaminase (ADA)-binding protein, has been implicated in HIV infection. Several studies have revealed a correlation between depletion of CD4+/CD26+ T lymphocytes, increased serum levels of ADA, and the evolution of AIDS in infected individuals. We show that in human B and T cell lines, irrespective of CD4 expression, 125I-labeled ADA binding to CD26 is inhibited by recombinant soluble HIV-1 envelope glycoprotein gp120 and by HIV-1 infectious particles. Accordingly, an anti-CD4 mAb, which inhibits the binding of gp120 to CD4 and blocks viral infection, did not affect inhibition of 125I-labeled ADA binding to CD26 by HIV particles...
April 15, 1997: Journal of Immunology: Official Journal of the American Association of Immunologists
K Becker, H Jablonowski, D Häussinger
We performed a computerized search on sulfadiazine-associated nephrotoxicity reported in human immunodefiency virus (HIV)-infected patients in the international literature. Including an original case report, we summarized 35 acquired immunodefiency syndrome (AIDS) patients from 1987 to 1995 in an analysis comparing their features to historical HIV-negative controls from the 1940s and 1950s. Likely due to a high prevalence of potential risk factors, incidence of sulfadiazine-associated renal impairment was 1...
July 1996: Medicine (Baltimore)
D Raahave, A Bremmelgaard
The surgical team is at risk of transmission of human immunodefiency virus (HIV) from the patient, which could progress to AIDS and death. In our hospital, we have estimated a probability of 0.20% per year, and 5.82% for 30 years in surgery. In view of this we have designed new procedures for surgical handicraft to reduce the risk from splash or injury to the surgical team. The surgeon must handle tissue with instruments only and minimize the use of fingers. Sharp instruments should, if possible be replaced by blunt types...
December 4, 1989: Ugeskrift for Laeger
R A Good, G S Incefy, J L Touraine
The initial work on the analysis and differentiation of human lymphoid cells is described. Cells from various lymphoid organs and blood were used as the antigen to prepare various antisera. These antisera were then used to define the lymphocyte populations of patients with primary and secondary immunodefiency. They are also being used to begin the analysis of the differentiation of the T-lymphocyte.
1976: Postgraduate Medical Journal
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