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https://www.readbyqxmd.com/read/29147087/hydrolysate-preparation-with-high-content-of-5-hydroxytryptophan-from-liquid-egg-protein-and-its-sleep-potentiating-activity
#1
Jung Il Kwon, Yooheon Park, Sung Hee Han, Hyung Joo Suh
Alcalase hydrolysis of liquid egg white was used to produce 5-hydroxytryptophan (HTP) under various conditions and investigate the sleep-potentiating activity of liquid egg white hydrolysate (LEH) on pentobarbital-induced sleep. Alcalase hydrolysis yielded the highest content of 5-HTP (13.50 μg/mL), while neutrase hydrolysis showed the lowest 5-HTP content (5.23 μg/mL). The liquid egg white to water ratio (1:1) was optimal for the production of 5-HTP with high amino-nitrogen (A-N) content and degree of hydrolysis...
2017: Korean Journal for Food Science of Animal Resources
https://www.readbyqxmd.com/read/29125937/novel-specificity-of-ido-enzyme-involved-in-the-biosynthesis-of-mating-pheromone-in-the-ciliate-blepharisma-stoltei
#2
Mayumi Sugiura, Hajime J Yuasa, Terue Harumoto
Mating pheromones (gamone 1 and gamone 2) in the ciliate Blepharisma are biologically active substances that trigger sexual reproduction (conjugation) under starvation conditions. Gamone 1 is a glycoprotein secreted by type I cells, and gamone 2 is a tryptophan (Trp)-derivative compound secreted by type II cells. Both gamones stimulate complementary mating type cells to promote each gamone production and induce pair formation. To elucidate the biosynthetic pathway of gamone 2, we investigated the enzymes involved in the pathway and the specificity of the enzymes...
September 18, 2017: Protist
https://www.readbyqxmd.com/read/29102139/short-communication-supplementation-of-colostrum-and-milk-with-5-hydroxy-l-tryptophan-affects-immune-factors-but-not-growth-performance-in-newborn-calves
#3
Lorenzo E Hernández-Castellano, Ranya Özçelik, Laura L Hernandez, Rupert M Bruckmaier
In ruminants, colostrum is the main source of immunoglobulins for the newborn animal, conferring immune protection until the immune system becomes active and able to synthesize its own immunoglobulins. Serotonin (5-HT), a biogenic amine derived from tryptophan, has stimulatory effects on many physiological processes, including components of the innate (mastocytes, eosinophils, and natural killer cells) and adaptive (T and B lymphocytes) immune systems. Based on the known effects of 5-HT on the immune system, we hypothesized that increased concentrations of 5-HT, through administration of its precursor 5-hydroxy-l-tryptophan (5-HTP), may positively affect development of the calf's immune system and therefore support health and growth performance during the first weeks of life...
October 25, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28953038/an-open-label-pilot-study-of-combined-augmentation-with-creatine-monohydrate-and-5-hydroxytryptophan-for-selective-serotonin-reuptake-inhibitor-or-serotonin-norepinephrine-reuptake-inhibitor-resistant-depression-in-adult-women
#4
Brent M Kious, Hana Sabic, Young-Hoon Sung, Douglas G Kondo, Perry Renshaw
PURPOSE: Many women with major depressive disorder (MDD) respond inadequately to standard treatments. Augmentation of conventional antidepressants with creatine monohydrate and 5-hydroxytryptophan (5-HTP) could correct deficits in serotonin production and brain bioenergetics associated with depression in women, yielding synergistic benefit. We describe an open-label study of 5-HTP and creatine augmentation in women with MDD who had failed selective serotonin reuptake inhibitor (SSRI) or serotonin-norepinephrine reuptake inhibitor (SNRI) monotherapy...
August 5, 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28922379/elevating-serotonin-pre-partum-alters-the-holstein-dairy-cow-hepatic-adaptation-to-lactation
#5
Samantha R Weaver, Allan S Prichard, Noah L Maerz, Austin P Prichard, Elizabeth L Endres, Lorenzo E Hernández-Castellano, Matthew S Akins, Rupert M Bruckmaier, Laura L Hernandez
Serotonin is known to regulate energy and calcium homeostasis in several mammalian species. The objective of this study was to determine if pre-partum infusions of 5-hydroxytryptophan (5-HTP), the immediate precursor to serotonin synthesis, could modulate energy homeostasis at the level of the hepatocyte in post-partum Holstein and Jersey dairy cows. Twelve multiparous Holstein cows and twelve multiparous Jersey cows were intravenously infused daily for approximately 7 d pre-partum with either saline or 1 mg/kg bodyweight of 5-HTP...
2017: PloS One
https://www.readbyqxmd.com/read/28916638/pharmacological-and-physiological-assessment-of-serotonin-formation-and-degradation-in-isolated-preparations-from-mouse-and-human-heart
#6
Ulrich Gergs, Franziska Jung, Igor B Buchwalow, Britt Hofmann, Andreas Simm, Hendrik Treede, Joachim Neumann
Using transgenic mice (TG) that overexpress the human 5-HT4a-receptor specifically in cardiomyocytes, we wanted to know whether 5-HT can be formed and degraded in the mammalian heart and whether this can likewise lead to inotropic and chronotropic effects in this TG model. We noted that the 5-HT precursor, 5-hydroxy-tryptophan (5-HTP), can exert inotropic and chronotropic effects in cardiac preparations from TG but not from wild type (WT): similar results were found in human atrial preparations, as well as in intact TG animals using echocardiography...
September 15, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/28888448/effect-of-explosion-puffed-coffee-on-locomotor-activity-and-behavioral-patterns-in-drosophila-melanogaster
#7
Bong Soo Ko, So Hyun Ahn, Dong Ouk Noh, Ki-Bae Hong, Sung Hee Han, Hyung Joo Suh
We hypothesized that the administration of explosion-puffed coffee, containing γ-aminobutyric acid (GABA) and 5-hydroxytryptophan (5-HTP), would be associated with a reduction of the caffeine effect on sleep behavior and behavioral patterns, which was investigated in a Drosophila model. The effects of feeding roasted coffee beans (RB), explosion-puffed coffee beans puffed at 0.75MPa and 0.9MPa (PB 7.5 and PB 9.0, respectively), or decaffeinated coffee beans (DeRB) on locomotor activity and behavioral patterns of Drosophila was analyzed...
October 2017: Food Research International
https://www.readbyqxmd.com/read/28855642/peripheral-serotonin-regulates-postoperative-intra-abdominal-adhesion-formation-in-mice
#8
Jianbin Bi, Simin Zhang, Zhaoqing Du, Jia Zhang, Yan Deng, Chang Liu, Jingyao Zhang
The aim of the present study is to investigate the role and potential mechanisms of peripheral serotonin in postoperative intra-abdominal adhesion formation in mice. The caecum-rubbing operations were conducted for intra-abdominal adhesion formation modelling in wild-type and Tph1-/- mice. The deficiency of serotonin significantly decreased the adhesion scores, weight loss, and adhesion thickness as well as levels of collagen fibres and hydroxyproline in the adhesive tissues. The Tph1-/- mice exhibited a milder inflammatory response and oxidative stress in the adhesive tissues than did the wild-type mice...
August 30, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28745143/high-fat-simple-carbohydrate-hfsc-diet-impairs-hypothalamic-and-corpus-striatal-serotonergic-metabolic-pathway-in-metabolic-syndrome-mets-induced-c57bl-6j-mice
#9
DSouza Serena Stephen, Asha Abraham
OBJECTIVES: To study the effect of specially formulated high-fat simple carbohydrate diet (HFSC) on the serotonin metabolic pathway in male C57BL/6J mice. METHODS: Previous studies from our laboratory have shown that specially formulated HFSC induces metabolic syndrome in C57BL/6J mice. In the present investigation, 5-hydroxytryptophan, serotonin and 5-hydroxyindoleacetic acid were analyzed in two brain regions (hypothalamus, corpus striatum), urine and plasma of HFSC-fed mice on a monthly basis up to 5 months using high-performance liquid chromatography fitted with electrochemical detector...
July 26, 2017: Nutritional Neuroscience
https://www.readbyqxmd.com/read/28686023/phoxi-a-high-quantum-yield-solvent-sensitive-blue-fluorescent-5-hydroxytryptophan-derivative-synthesized-within-ten-minutes-under-aqueous-ambient-conditions
#10
Alexandre Grigoryan, Azaria S Eisenberg, Laura J Juszczak
Multiple tryptophan (Trp) proteins are not amenable to fluorescence study because individual residue emission is not resolvable. Biosynthetic incorporation of an indole analogue such as 5-hydroxyindole has not provided sufficient spectroscopic resolution because of low quantum yield and small emission shift. Here, 5-hydroxyindole is used as the starting framework for building a blue emitting fluorophore of high quantum yield, 2-phenyl-6H-oxazolo[4,5-e]indole (PHOXI). This is a three reagent reaction completed in 10 min under ambient conditions in borate buffer at pH 8...
August 3, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28601766/trace-level-determination-of-5-hydroxytryptamine-and-its-related-indoles-in-amniotic-fluid-by-gas-chromatography-mass-spectrometry
#11
Hongmei Shi, Bo Wang, Lingmei Niu, Mengsi Cao, Weijun Kang, Kaoqi Lian, Pingping Zhang
5-hydroxytryptamine (5-HT) and its derivatives are endogenously active substances involved in multiple physiological and pathological processes. A novel method of detetermining 5-hydroxyindole ethanol (5-HTOL), 5-hydroxyindole acetic acid (5-HIAA), 5-hydroxytryptophan (5-HTP) and 5-HT in amniotic fluid by gas chromatography-mass spectrometry (GC-MS) was established based on a modified method of derivatization by silanization, in combination with solid-phase extraction pretreatment. Good linearity was achieved in the tested calibration range...
September 5, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28502117/passive-membrane-penetration-of-the-serotonin-precursor-5-hydroxytryptophan-is-controlled-by-its-zwitterion
#12
Károly Mazák, Béla Noszál
Species-specific partition coefficients in the octanol/water system were determined for the neurotransmitter serotonin (5-HT) and its precursor 5-hydroxytryptophan (5-HTP). The pH-independent partition coefficients (p) of the individual microspecies were determined by combination of experimentally measured distribution constants and a custom-tailored evaluation method, using highly similar auxiliary compounds. Experimental microscopic partition coefficients for triprotic molecules have only been reported before for thyroxine and its derivatives...
August 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28456683/patchouli-alcohol-ameliorates-dextran-sodium-sulfate-induced-experimental-colitis-and-suppresses-tryptophan-catabolism
#13
Chang Qu, Zhong-Wen Yuan, Xiu-Ting Yu, Yan-Feng Huang, Guang-Hua Yang, Jian-Nan Chen, Xiao-Ping Lai, Zi-Ren Su, Hui-Fang Zeng, Ying Xie, Xiao-Jun Zhang
Despite the increased morbidity of ulcerative colitis (UC) in recent years, available treatments remain unsatisfactory. Pogostemon cablin has been widely applied to treat a variety of gastrointestinal disorders in clinic for centuries, in which patchouli alcohol (PA, C15H26O) has been identified as the major active component. This study attempted to determine the bioactivity of PA on dextran sulfate sodium (DSS)-induced mice colitis and clarify the mechanism of action. Acute colitis was induced in mice by 3% DSS for 7 days...
April 27, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/28434742/endocrine-and-metabolic-changes-in-transition-dairy-cows-are-affected-by-prepartum-infusions-of-a-serotonin-precursor
#14
Lorenzo E Hernández-Castellano, Laura L Hernandez, Helga Sauerwein, Rupert M Bruckmaier
Serotonin (5-HT) has been shown to be involved in calcium homeostasis, modulating calcium concentration in blood. In addition, 5-HT participates in a variety of metabolic pathways, mainly through the modulation of glucose and lipid metabolism. The hypothesis of the present study was that the prepartum administration of 5-hydroxy-l-tryptophan (5-HTP), a 5-HT precursor, would affect endocrine systems related to calcium homeostasis, and interact with other endocrine and metabolic pathways during the transition period...
April 20, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28413824/perturbation-of-serotonin-homeostasis-during-adulthood-affects-serotonergic-neuronal-circuitry
#15
Marta Pratelli, Sara Migliarini, Barbara Pelosi, Francesco Napolitano, Alessandro Usiello, Massimo Pasqualetti
Growing evidence shows that the neurotransmitter serotonin (5-HT) modulates the fine-tuning of neuron development and the establishment of wiring patterns in the brain. However, whether serotonin is involved in the maintenance of neuronal circuitry in the adult brain remains elusive. Here, we use a Tph2(fl)°(x) conditional knockout (cKO) mouse line to assess the impact of serotonin depletion during adulthood on serotonergic system organization. Data show that the density of serotonergic fibers is increased in the hippocampus and decreased in the thalamic paraventricular nucleus (PVN) as a consequence of brain serotonin depletion...
March 2017: ENeuro
https://www.readbyqxmd.com/read/28413401/parkinsonism-in-association-with-dihydropteridine-reductase-deficiency
#16
Yoshiaki Takahashi, Yasuhiro Manabe, Yumiko Nakano, Taijun Yunoki, Syoichiro Kono, Hisashi Narai, Mahoko Furujo, Koji Abe
We report a 16-year-old man with disorders of tetrahydrobiopterin metabolism due to dihydropteridine reductase (DHPR) deficiency. He revealed moderate mental retardation, parkinsonism, and spastic paralysis with levodopa and 5-hydroxytryptophan (5-HTP) supplementation from the age of 2 months. Brain MRI showed high intensity areas in bilateral frontal and posterior deep white matter on fluid-attenuated inversion recovery (FLAIR). Coronal FLAIR image showed a high signal in bilateral pyramidal tracts. Single photon computed tomography (SPECT) imaging of the dopamine transporter was normal...
January 2017: Case Reports in Neurology
https://www.readbyqxmd.com/read/28412215/involvement-of-serotonergic-noradrenergic-and-dopaminergic-systems-in-the-antidepressant-like-effect-of-ginsenoside-rb1-a-major-active-ingredient-of-panax-ginseng-c-a-meyer
#17
Guo-Li Wang, Zhong-Mei He, Hong-Yan Zhu, Yu-Gang Gao, Yan Zhao, He Yang, Liangxue Zhang
ETHNOPHARMACOLOGY RELEVANCE: Ginsenoside Rb1, a 20 (S)-protopanaxadiol, is a major active ingredient of Panax ginseng C.A. Meyer, which as the King of Chinese herbs, has been wildly used for the treatment of central nervous system diseases. Previous studies have shown that 20 (S)-protopanaxadiol possesses a novel antidepressant-like effect in the treatment of depression, whereas ginsenoside Rb1 in depression has been rarely reported. AIM OF THE REVIEW: The present study was to investigate the antidepressant-like effect of ginsenoside Rb1 and its relevant mechanisms...
April 13, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28327452/sensitive-detection-of-l-5-hydroxytryptophan-based-on-molecularly-imprinted-polymers-with-graphene-amplification
#18
Lu Chen, Hui-Ting Lian, Xiang-Ying Sun, Bin Liu
A novel electrochemical sensor was presented for the determination of L-5-hydroxytryptophan (L-5-HTP) based on a graphene-chitosan molecularly imprinted film modified on the surface of glassy carbon electrode (GR-MIP/GCE). The morphology and composition of the imprinted film were observed in field emission scanning electron microscopy (FESEM), raman spectroscopy and fourier transform infrared (FTIR). The properties of the sensor were evaluated by electrochemical techniques. Under the optimal conditions, the peak currents of L-5-HIP were found to be linear in the concentration range of 0...
June 1, 2017: Analytical Biochemistry
https://www.readbyqxmd.com/read/28256473/antidepressant-anxiolytic-activities-of-n-pyridin-3-yl-quinoxalin-2-carboxamide-a-novel-serotonin-type-3-receptor-antagonist-in-behavioural-animal-models
#19
Dilip Kumar Pandey, Thangraj Devadoss, Neha Modak, Radhakrishnan Mahesh
BACKGROUND & OBJECTIVES: Alteration in the serotonin leads to the psychological illness, such as depression, anxiety, schizophrenia, eating disorders, obsessive-compulsive disorder, panic disorders and migraines. The objective of the current study was to investigate the antidepressant and anxiolytic activities of N-(pyridin-3-yl) quinoxalin-2-carboxamide (QCF-21), a novel 5-HT3receptor antagonist in preclinical models of depression and anxiety. METHODS: Antidepressant activity was evaluated in preliminary tests such as forced swim and tail suspension tests (FST & TST)...
October 2016: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/28246291/-11-c-5-hydroxy-tryptophan-pet-for-assessment-of-islet-mass-during-progression-of-type-2-diabetes
#20
Lina Carlbom, Daniel Espes, Mark Lubberink, Mats Martinell, Lars Johansson, Håkan Ahlström, Per-Ola Carlsson, Olle Korsgren, Olof Eriksson
[(11)C]5-hydroxy-tryptophan ([(11)C]5-HTP) positron emission tomography of the pancreas has been shown to be a surrogate imaging biomarker of pancreatic islet mass. The change in islet mass in different stages of type 2 diabetes (T2D) as measured by noninvasive imaging is currently unknown. Here, we describe a cross-sectional study where subjects at different stages of T2D development with expected stratification of pancreatic islet mass were examined in relation to individuals without diabetes. The primary outcome was the [(11)C]5-HTP uptake and retention in pancreas, as a surrogate marker for the endogenous islet mass...
May 2017: Diabetes
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