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https://www.readbyqxmd.com/read/28210931/serotonin-syndrome-from-5-hydroxytryptophan-supplement-ingestion-in-a-9-month-old-labrador-retriever
#1
Hopkins Jennifer, Pardo Mariana, Bischoff Karyn
INTRODUCTION: 5-Hydroxytryptophan (5-HTP) supplements are available over the counter and labeled as sleeping aids and anxiolytics for human use. 5-HTP is a serotonin precursor and overdose can lead to serotonin syndrome. CASE REPORT: A 9-month-old female Labrador retriever was evaluated after ingestion of a 5-HTP supplement. Signs of agitation developed within 1 h of ingestion, and emesis was attempted by the owner with  3% hydrogen peroxide (H2O2) orally. On presentation, the dog was obtunded, bilaterally mydriatic and salivating...
February 16, 2017: Journal of Medical Toxicology: Official Journal of the American College of Medical Toxicology
https://www.readbyqxmd.com/read/28145727/estrogen-dependent-effects-of-5-hydroxytryptophan-on-cortical-spreading-depression-in-rat-modelling-the-serotonin-ovarian-hormone-interaction-in-migraine-aura
#2
Virginie Chauvel, Sylvie Multon, Jean Schoenen
Background Cortical spreading depression (CSD) is the likely culprit of the migraine aura. Migraine is sexually dimorphic and thought to be a "low 5-HT" condition. We sought to decipher the interrelation between serotonin, ovarian hormones and cortical excitability in a model of migraine aura. Methods Occipital KCl-induced CSDs were recorded for one hour at parieto-occipital and frontal levels in adult male (n = 16) and female rats (n = 64) one hour after intraperitoneal (i.p.) injection of 5-hydroxytryptophan (5-HTP) or NaCl...
January 1, 2017: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/28127513/preliminary-fmri-findings-concerning-the-influence-of-5-htp-on-food-selection
#3
Stephanos Ioannou, Adrian L Williams
OBJECTIVE: This functional magnetic resonance imaging study was designed to observe how physiological brain states can alter food preferences. A primary goal was to observe food-sensitive regions and moreover examine whether 5-HTP intake would activate areas which have been associated with appetite suppression, anorexia, satiety, and weight loss. METHODS AND PROCEDURE: Fourteen healthy male and female participants took part in the study, of which half of them received the supplement 5-HTP and the rest vitamin C (control) on an empty stomach...
January 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28113063/5-hydroxytryptophan-a-major-product-of-tryptophan-degradation-is-essential-for-optimal-replication-of-human-parainfluenza-virus
#4
M A G Rabbani, Sailen Barik
Interferon (IFN) exerts its antiviral effect by inducing a large family of cellular genes, named interferon (IFN)-stimulated genes (ISGs). An intriguing member of this family is indoleamine 2,3-dioxygenase (IDO), which catalyzes the first and rate-limiting step of the main branch of tryptophan (Trp) degradation, the kynurenine pathway. We recently showed that IDO strongly inhibits human parainfluenza virus type 3 (PIV3), a significant respiratory pathogen. Here, we show that 5-hydoxytryptophan (5-HTP), the first product of an alternative branch of Trp degradation and a serotonin precursor, is essential to protect virus growth against IDO in cell culture...
January 20, 2017: Virology
https://www.readbyqxmd.com/read/27988124/increased-serum-serotonin-improves-parturient-calcium-homeostasis-in-dairy-cows
#5
Lorenzo E Hernández-Castellano, Laura L Hernandez, Samantha Weaver, Rupert M Bruckmaier
Hypocalcemia in dairy cows is caused by the sudden increase in calcium demand by the mammary gland for milk production at the onset of lactation. Serotonin (5-HT) is a key factor for calcium homeostasis, modulating calcium concentration in blood. Therefore, it is hypothesized that administration of 5-hydroxy-l-tryptophan (5-HTP), a 5-HT precursor, can increase 5-HT concentrations in blood and, in turn, induce an increase in blood calcium concentration. In this study, 20 Holstein dairy cows were randomly assigned to 2 experimental groups...
February 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/27907050/when-is-the-brain-dead-living-like-electrophysiological-responses-and-photon-emissions-from-applications-of-neurotransmitters-in-fixed-post-mortem-human-brains
#6
Michael A Persinger, Nicolas Rouleau, Nirosha J Murugan, Lucas W E Tessaro, Justin N Costa
The structure of the post-mortem human brain can be preserved by immersing the organ within a fixative solution. Once the brain is perfused, cellular and histological features are maintained over extended periods of time. However, functions of the human brain are not assumed to be preserved beyond death and subsequent chemical fixation. Here we present a series of experiments which, together, refute this assumption. Instead, we suggest that chemical preservation of brain structure results in some retained functional capacity...
2016: PloS One
https://www.readbyqxmd.com/read/27898359/motherhood-and-infant-contact-regulate-neuroplasticity-in-the-serotonergic-midbrain-dorsal-raphe
#7
M Allie Holschbach, Joseph S Lonstein
The adult brain shows remarkable neuroplasticity in response to hormones and the socioemotional modifications that they influence. In females with reproductive and maternal experience, this neuroplasticity includes the birth and death of cells in several forebrain regions involved in maternal caregiving and postpartum affective state. Such plasticity in midbrain sites critical for these behavioral and emotional processes has never been examined, though. By visualizing bromodeoxyuridine (BrdU) to label mitotic cells, NeuroD for neuronal precursors, and TUNEL to identify dying cells, we found that the midbrain dorsal raphe nucleus (DR, the source of most ascending serotoninergic projections) exhibited significant neuroplasticity in response to motherhood...
February 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/27894208/whole-body-mri-including-diffusion-weighted-mri-compared-with-5-htp-pet-ct-in-the-detection-of-neuroendocrine-tumors
#8
Lina Carlbom, José Caballero-Corbalán, Dan Granberg, Jens Sörensen, Barbro Eriksson, Håkan Ahlström
AIM: We wanted to explore if whole-body magnetic resonance imaging (MRI) including diffusion-weighted (DW) and liver-specific contrast agent-enhanced imaging could be valuable in lesion detection of neuroendocrine tumors (NET). [11C]-5-Hydroxytryptophan positron emission tomography/computed tomography (5-HTP PET/CT) was used for comparison. MATERIALS AND METHODS: Twenty-one patients with NET were investigated with whole-body MRI, including DW imaging (DWI) and contrast-enhanced imaging of the liver, and whole-body 5-HTP PET/CT...
November 29, 2016: Upsala Journal of Medical Sciences
https://www.readbyqxmd.com/read/27882537/neurochemical-and-behavioral-effects-of-hypidone-hydrochloride-yl-0919-a-novel-combined-selective-serotonin-reuptake-inhibitor-and-partial-5-ht1a-agonist
#9
Li-Ming Zhang, Xiao-Yun Wang, Nan Zhao, Yu-Lu Wang, Xiao-Xu Hu, Yu-Hua Ran, Yan-Qin Liu, You-Zhi Zhang, Ri-Fang Yang, Yun-Feng Li
The purpose of the present study was to investigate the pharmacology of hypidone hydrochloride (YL-0919), a novel selective serotonin reuptake inhibitor (SSRI) and 5-hydroxytryptamine (5-HT)1A receptor agonist with high affinity for serotonin transporter (SERT) and 5-HT1A receptors. YL-0919 promoted [(35) S]GTPγ S binding at 85% of the magnitude of the full 5-HT1A receptor agonist 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT), suggesting that YL-0919 is a high-efficacy partial agonist of 5-HT1A receptors...
November 24, 2016: British Journal of Pharmacology
https://www.readbyqxmd.com/read/27692695/adjunctive-5-hydroxytryptophan-slow-release-for-treatment-resistant-depression-clinical-and-preclinical-rationale
#10
Jacob P R Jacobsen, Andrew D Krystal, K Ranga R Krishnan, Marc G Caron
Serotonin transporter (SERT) inhibitors treat depression by elevating brain extracellular 5-hydroxytryptamine (5-HTExt). However, only one-third of patients respond adequately. Treatment-resistant depression (TRD) is a major unmet need. Interestingly, elevating 5-HTExt beyond what is achieved by a SERT inhibitor appears to treat TRD. Adjunctive administration of 5-hydroxytryptophan (5-HTP) safely elevates 5-HTExt beyond the SERT inhibitor effect in humans; however, 5-HTP cannot be a clinically viable drug because of its poor pharmacokinetics...
September 28, 2016: Trends in Pharmacological Sciences
https://www.readbyqxmd.com/read/27617751/women-with-premenstrual-dysphoria-lack-the-seemingly-normal-premenstrual-right-sided-relative-dominance-of-5-htp-derived-serotonergic-activity-in-the-dorsolateral-prefrontal-cortices-a-possible-cause-of-disabling-mood-symptoms
#11
Olle Eriksson, Anders Wall, Ulf Olsson, Ina Marteinsdottir, Maria Holstad, Hans Ågren, Per Hartvig, Bengt Långström, Tord Naessén
STUDY OBJECTIVE: To investigate potential quantitative and qualitative differences in brain serotonergic activity between women with Premenstrual Dysphoria (PMD) and asymptomatic controls. BACKGROUND: Serotonin-augmenting drugs alleviate premenstrual mood symptoms in the majority of women with PMD while serotonin-depleting diets worsen PMD symptoms, both indicating intrinsic differences in brain serotonergic activity in women with PMD compared to asymptomatic women...
2016: PloS One
https://www.readbyqxmd.com/read/27473286/altered-tryptophan-metabolism-in-human-meningioma
#12
Noble Kumar Talari, Manas Panigrahi, Sailaja Madigubba, Sundaram Challa, Prakash Babu Phanithi
Meningiomas are the neoplasms that arise from the arachnoid cells of the meninges. It was reported that cancer cells escape from immune system through the metabolism of an aromatic essential amino acid tryptophan (TRP) via Kynurenine (KYN) pathway. However, the role of TRP metabolites such as, 5-Hydroxy tryptophan (5-HTP), 5-Hydroxy tryptamine (5-HT), N-acetyl serotonin (NAS), Melatonin (MEL), KYN, N-acetyl tryptamine, 5-Hydroxy indole acetic acid (5-HIAA) and 5-Methoxy indole acetic acid is not yet evaluated in human meningioma...
July 29, 2016: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/27390301/elevation-of-circulating-serotonin-improves-calcium-dynamics-in-the-peripartum-dairy-cow
#13
Samantha R Weaver, Austin P Prichard, Elizabeth L Endres, Stefanie A Newhouse, Tonia L Peters, Peter M Crump, Matthew S Akins, Thomas D Crenshaw, Rupert M Bruckmaier, Laura L Hernandez
Hypocalcemia is a metabolic disorder that affects dairy cows during the transition from pregnancy to lactation. Twelve multiparous Holstein cows and twelve multiparous Jersey cows were intravenously infused daily for approximately 7 days prepartum with either saline or 1.0mg/kg bodyweight of the immediate precursor to serotonin synthesis, 5hydroxy-l-tryptophan (5-HTP). On infusion days, blood was collected before, after, and at 2, 4, and 8h postinfusion. Blood and urine were collected daily before the infusion period, for 14 days postpartum and on day 30 postpartum...
July 2016: Journal of Endocrinology
https://www.readbyqxmd.com/read/27344020/interactive-effect-of-light-colours-and-temporal-synergism-of-circadian-neural-oscillations-in-reproductive-regulation-of-japanese-quail
#14
Suneeta Yadav, Chandra Mohini Chaturvedi
Avian literature reports the modulation of 'photoperiodic gonadal responses' by the temporal phase relation of serotonergic and dopaminergic oscillations in Japanese quail. But, the modulation of 'light colour responses' by the temporal synergism of neural oscillations is not yet known. Hence the present study was designed to investigate the interaction of the light colour (blue, red) and the phase relation of neural oscillations in the reproductive regulation of Japanese quail. Three week old male Japanese quail were divided into two groups and maintained under a long day length condition (16L:8D) and were exposed to a 30 lux intensity of blue LED (light emitting diode) (B LED) and a red LED light (R LED)...
September 2016: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/27325286/positron-emission-tomography-to-assess-the-outcome-of-intraportal-islet-transplantation
#15
Olof Eriksson, Ramkumar Selvaraju, Torsten Eich, Mariam Willny, Torkel B Brismar, Lina Carlbom, Håkan Ahlström, Gunnar Tufvesson, Torbjörn Lundgren, Olle Korsgren
No imaging methodology currently exists to monitor viable islet mass after clinical intraportal islet transplantation. We investigated the potential of the endocrine positron emission tomography (PET) marker [(11)C]5-hydroxytryptophan ([(11)C]5-HTP) for this purpose. In a preclinical proof-of-concept study, the ex vivo and in vivo [(11)C]5-HTP signal was compared with the number of islets transplanted in rats. In a clinical study, human subjects with an intraportal islet graft (n = 8) underwent two [(11)C]5-HTP PET and MRI examinations 8 months apart...
September 2016: Diabetes
https://www.readbyqxmd.com/read/27302625/5-hydroxytryptophan-a-precursor-for-serotonin-synthesis-reduces-seizure-induced-respiratory-arrest
#16
Honghai Zhang, Haiting Zhao, Xiaoxuan Yang, Qingsheng Xue, Joseph F Cotten, Hua-Jun Feng
OBJECTIVE: The DBA/1 mouse is a relevant animal model of sudden unexpected death in epilepsy (SUDEP), as it exhibits seizure-induced respiratory arrest (S-IRA) evoked by acoustic stimulation, followed by cardiac arrhythmia and death. Defects in serotonergic neurotransmission may contribute to S-IRA. The tryptophan hydroxylase-2 (TPH2) enzyme converts L-tryptophan to 5-hydroxytryptophan (5-HTP), a precursor for central nervous system (CNS) serotonin (5-HT) synthesis; and DBA/1 mice have a polymorphism that decreases TPH2 activity...
August 2016: Epilepsia
https://www.readbyqxmd.com/read/27207953/apoptosis-mediated-testicular-alteration-in-japanese-quail-coturnix-coturnix-japonica-in-response-to-temporal-phase-relation-of-serotonergic-and-dopaminergic-oscillations
#17
Somanshu Banerjee, Kazuyoshi Tsutsui, Chandra Mohini Chaturvedi
Reproductive performance of many avian species, including Japanese quail, is reported to be modulated by specific temporal phase relation of serotonergic and dopaminergic oscillations. Accordingly, it has been shown that the serotonin precursor 5-HTP and the dopamine precursor l-DOPA given 8 h apart induce gonadal suppression and given 12 h apart lead to gonadal stimulation, while other temporal relationships were found to be ineffective. In the present study, we investigated the effects of 8- and 12-h phase relation of neural oscillations on testicular responses including expression of GnRH-I, GnIH, pro-apoptotic proteins (p53 and Bax), inactive and active executioner caspase-3, and the uncleaved DNA repair enzyme PARP-1...
May 15, 2016: Journal of Experimental Biology
https://www.readbyqxmd.com/read/27189957/serotonin-synthesis-rate-and-the-tryptophan-hydroxylase-2-g-703t-polymorphism-in-social-anxiety-disorder
#18
Tomas Furmark, Ina Marteinsdottir, Andreas Frick, Kerstin Heurling, Maria Tillfors, Lieuwe Appel, Gunnar Antoni, Per Hartvig, Håkan Fischer, Bengt Långström, Elias Eriksson, Mats Fredrikson
It is disputed whether anxiety disorders, like social anxiety disorder, are characterized by serotonin over- or underactivity. Here, we evaluated whether our recent finding of elevated neural serotonin synthesis rate in patients with social anxiety disorder could be reproduced in a separate cohort, and whether allelic variation in the tryptophan hydroxylase-2 (TPH2) G-703T polymorphism relates to differences in serotonin synthesis assessed with positron emission tomography. Eighteen social anxiety disorder patients and six healthy controls were scanned during 60 minutes in a resting state using positron emission tomography and 5-hydroxy-L-[β -(11)C]tryptophan, [(11)C]5-HTP, a substrate of the second enzymatic step in serotonin synthesis...
October 2016: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/27168990/potential-spawn-induction-and-suppression-agents-in-caribbean-acropora-cervicornis-corals-of-the-florida-keys
#19
Mark Flint, John T Than
The enhanced ability to direct sexual reproduction may lead to improved restoration outcomes for Acropora cervicornis. Gravid fragments of A. cervicornis were maintained in a laboratory for two sequential trials in the seven days prior to natural spawning in the Florida Keys. Ten replicates of five chemicals known to affect spawning in various invertebrate taxa were tested. Hydrogen peroxide at 2 mM (70%) and L-5-hydroxytryptophan (5-HTP) at 5 (40%) and 20 µM (30%) induced spawning within 15.4 h, 38.8 h and 26...
2016: PeerJ
https://www.readbyqxmd.com/read/27150227/sleep-promoting-effects-of-the-gaba-5-htp-mixture-in-vertebrate-models
#20
Ki-Bae Hong, Yooheon Park, Hyung Joo Suh
The aim of this study was to investigate the sleep-promoting effect of combined γ-aminobutyric acid (GABA) and 5-hydroxytryptophan (5-HTP) on sleep quality and quantity in vertebrate models. Pentobarbital-induced sleep test and electroencephalogram (EEG) analysis were applied to investigate sleep latency, duration, total sleeping time and sleep quality of two amino acids and GABA/5-HTP mixture. In addition, real-time PCR and HPLC analysis were applied to analyze the signaling pathway. The GABA/5-HTP mixture significantly regulated the sleep latency, duration (p<0...
September 1, 2016: Behavioural Brain Research
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