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https://www.readbyqxmd.com/read/29080788/l-theanine-prevents-etec-induced-liver-damage-by-reducing-intrinsic-apoptotic-response-and-inhibiting-erk1-2-and-jnk1-2-signaling-pathways
#1
Zhihua Gong, Qiuling Liu, Ling Lin, Yanli Deng, Shuxian Cai, Zunying Liu, Sheng Zhang, Wenjun Xiao, Shuo Xiong, Dong Chen
l-Theanine (LTA; γ-glutamylethylamide), a peculiar non-protein-derived amino acid isolated from tea, is widely used as a functional ingredient and dietary supplement. l-Theanine has been confirmed to have hepatoprotective effects, but the underlying mechanism remains unknown. This study investigated the protective effect of l-Theanine-in vivo, using an enterotoxigenic Escherichia coli (ETEC)-infected mouse model. l-Theanine significantly decreased the elevated serum activities of both aspartate aminotransferase (AST) and alanine aminotransferase (ALT), two biomarkers of hepatic impairment...
October 28, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29037735/l-theanine-an-astounding-sui-generis-integrant-in-tea
#2
REVIEW
Eshita Sharma, Robin Joshi, Ashu Gulati
l-theanine (l-Th), a non-protein amino acid present in tea, is a valuable nutraceutical product with unique health benefits and used as an additive in food industry. l-Th enhances the umami taste but its use is limited due to its inadequate production. Different extraction approaches from tea shoots, chemical synthesis to microbial transformation have been tried to meet its demand. In vitro, in vivo as well as clinical studies have shown its positive effect in regulating CNS disorders. l-Th has become choice ingredient in CNS active products due to its anti-stress and neuroprotective role in dementias particularly in retrogression of Alzheimer's...
March 1, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29034642/-construction-of-recombinant-strains-co-expressing-ppk-and-gmas-for-the-synthesis-of-l-theanine
#3
Yuan Li, Shan Liu, Jun Zhu
Recombinant strains expressing enzymes for ATP regeneration and L-theanine production were constructed and used for the synthesis of L-theanine. The ppk gene encoding polyphosphate kinase (PPK) from Rhodobacter sphaeroides and gmas gene encoding γ-glutamylmethylamide synthetase (GMAS) from Methylovorus mays were synthesized, and two recombinant plasmids, pETDuet-ppk+gmas and pET21a-ppk+gmas were constructed for co-expression of PPK and GMAS in Escherichia coli BL21(DE3). SDS-PAGE analysis showed that PPK and GMAS were overexpressed in soluble form in both recombinant strains...
December 25, 2016: Sheng Wu Gong Cheng Xue Bao, Chinese Journal of Biotechnology
https://www.readbyqxmd.com/read/29020770/csgogat-is-important-in-dynamic-changes-of-theanine-content-in-postharvest-tea-plant-leaves-under-different-temperature-and-shading-spreadings
#4
Zhi-Wei Liu, Hui Li, Wen-Li Wang, Zhi-Jun Wu, Xin Cui, Jing Zhuang
We analyzed the changes of theanine content in postharvest tea leaves under high temperature (38 °C), low temperature (4 °C), and shading spreadings by using ultrahigh-performance liquid chromatography. The differentially expressed proteins (DEPs), CsFd-GOGAT and CsNADH-GOGAT, which are involved in theanine biosynthesis pathway, were identified from the corresponding proteome data. The protein-protein interactions of CsFd-GOGAT and CsNADH-GOGAT, CsTS1, or CsNiR were verified by yeast two-hybrid technology...
October 25, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28971241/effects-of-l-theanine-on-anxiety-like-behavior-cerebrospinal-fluid-amino-acid-profile-and-hippocampal-activity-in-wistar-kyoto-rats
#5
Shintaro Ogawa, Miho Ota, Jun Ogura, Koichi Kato, Hiroshi Kunugi
RATIONALE AND OBJECTIVES: The amino acid L-theanine (N-ethyl-L-glutamine) has historically been considered a relaxing agent. In the present study, we examined the effects of repeated L-theanine administration on behavior, levels of amino acids in the cerebrospinal fluid (CSF), and hippocampal activity in Wistar Kyoto (WKY) rats, an animal model of anxiety and depressive disorders. METHODS: Behavioral tests were performed after 7-10 days of L-theanine (0.4 mg kg(-1) day(-1)) or saline administration, followed by CSF sampling for high-performance liquid chromatography (HPLC) analysis...
October 3, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28946262/validation-of-a-reversed-phase-high-performance-liquid-chromatographic-method-for-the-determination-of-free-amino-acids-in-rice-using-l-theanine-as-the-internal-standard
#6
G V V Liyanaarachchi, K R R Mahanama, H P P S Somasiri, P A N Punyasiri
The study presents the validation results of the method carried out for analysis of free amino acids (FAAs) in rice using l-theanine as the internal standard (IS) with o-phthalaldehyde (OPA) reagent using high-performance liquid chromatography-fluorescence detection. The detection and quantification limits of the method were in the range 2-16μmol/kg and 3-19μmol/kg respectively. The method had a wide working range from 25 to 600μmol/kg for each individual amino acid, and good linearity with regression coefficients greater than 0...
February 1, 2018: Food Chemistry
https://www.readbyqxmd.com/read/28938517/green-tea-camellia-sinensis-and-l-theanine-medicinal-values-and-beneficial-applications-in-humans-a-comprehensive-review
#7
REVIEW
Muhammad Saeed, Muhammad Naveed, Muhammad Arif, Mohib Ullah Kakar, Robina Manzoor, Mohamed Ezzat Abd El-Hack, Mahmoud Alagawany, Ruchi Tiwari, Rekha Khandia, Ashok Munjal, Kumaragurubaran Karthik, Kuldeep Dhama, Hafiz M N Iqbal, Maryam Dadar, Chao Sun
Green tea (Camellia sinensis) is a famous herb, and its extract has been extensively used in traditional Chinese medicinal system. In this context, several studies have revealed its health benefits and medicinal potentialities for several ailments. With ever increasing scientific knowledge, search for safer, potential and novel type of health-related supplements quest, scientists are re-directing their research interests to explore natural resources i.e. medicinal herbs/plant derived compounds. Green tea consumption has gained a special attention and popularity in the modern era of changing lifestyle...
November 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28911738/effects-of-introducing-theanine-or-glutamic-acid-core-to-tralopyril-on-systemicity-and-insecticidal-activity
#8
Wen Yang, Yao Chen, Ying Zhang, Xiu-Bing Gao, Yu-Feng Zhou
Tralopyril was the active agent of a pro-insecticide chlorfenapyr. To simultaneously solve the problems of the phytotoxicity and non-systemic insecticidal activity of tralopyril, four new tralopyril conjugates containing theanine or glutamic acid moieties were designed and synthesized. Their phytotoxicity to tea shoot, phloem systemicity, and insecticidal activity were evaluated. Phytotoxic symptoms were not observed after the tea shoots were exposed to the four conjugates at concentrations of 2mM. The phloem mobility test on Ricinus communis L...
September 2017: Pesticide Biochemistry and Physiology
https://www.readbyqxmd.com/read/28899506/green-tea-effects-on-cognition-mood-and-human-brain-function-a-systematic-review
#9
REVIEW
Edele Mancini, Christoph Beglinger, Jürgen Drewe, Davide Zanchi, Undine E Lang, Stefan Borgwardt
BACKGROUND: Green tea (Camellia sinensis) is a beverage consumed for thousands of years. Numerous claims about the benefits of its consumption were stated and investigated. As green tea is experiencing a surge in popularity in Western culture and as millions of people all over the world drink it every day, it is relevant to understand its effects on the human brain. PURPOSE: To assess the current state of knowledge in the literature regarding the effects of green tea or green tea extracts, l-theanine and epigallocatechin gallate both components of green tea-on general neuropsychology, on the sub-category cognition and on brain functions in humans...
October 15, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/28852881/itraq-based-proteomics-monitors-the-withering-dynamics-in-postharvest-leaves-of-tea-plant-camellia-sinensis
#10
Zhi-Jun Wu, Hong-Yu Ma, Jing Zhuang
Tea plant [Camellia sinensis (L.) O. Kuntze] is a typical leaf-type beverage crop. Many secondary metabolites, such as tea polyphenols, theanine, and caffeine that accumulated in tea leaves are beneficial to human health. The fresh leaves of tea plant are harvested and timely processed into tea products with different flavors. The withering of fresh tea leaves is the first step in tea processing and directly affects tea color, taste, and fragrance. To understand the molecular mechanism that influences tea quality during withering, we investigated the dynamic changes in the proteome of postharvest tea leaves in four withering stages (0, 1, 4, and 12 h treatments)...
August 29, 2017: Molecular Genetics and Genomics: MGG
https://www.readbyqxmd.com/read/28825557/analysis-of-theanine-in-tea-camellia-sinensis-dietary-ingredients-and-supplements-by-high-performance-liquid-chromatography-with-postcolumn-derivatization-single-laboratory-validation-first-action-2016-10
#11
Mariaova Ofitser, Sareeta Nerkar, Brian T Schaneberg, Nour Eddine Es-Safi, Tetsuhisa Goto, Martha Jennens, Holly E Johnson, Philip J Koerner, Pam A Marone, Melissa Meaney Phillips, Tom Phillips, Klaus Reif, Aniko M Solyom, Darryl M Sullivan, Marina Torres, Jinchuan Yang, Kurt Young, Yanjun Zhang
No abstract text is available yet for this article.
January 1, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28812313/current-and-potential-pharmacological-and-psychosocial-interventions-for-anxiety-symptoms-and-disorders-in-patients-with-schizophrenia-structured-review
#12
REVIEW
Fleur M Howells, David G Kingdon, David S Baldwin
OBJECTIVE: Between 30% and 62% of patients with schizophrenia present with co-morbid anxiety disorders that are associated with increased overall burden. Our aim was to summarize current and potential interventions for anxiety in schizophrenia. DESIGN: Structured review, summarizing pharmacological and psychosocial interventions used to reduce anxiety in schizophrenia and psychosis. RESULTS: Antipsychotics have been shown to reduce anxiety, increase anxiety, or have no effect...
August 15, 2017: Human Psychopharmacology
https://www.readbyqxmd.com/read/28812027/l-theanine-administration-modulates-the-absorption-of-dietary-nutrients-and-expression-of-transporters-and-receptors-in-the-intestinal-mucosa-of-rats
#13
Qiongxian Yan, Haiou Tong, Shaoxun Tang, Zhiliang Tan, Xuefeng Han, Chuanshe Zhou
L-theanine has various advantageous functions for human health; whether or not it could mediate the nutrients absorption is unknown yet. The effects of L-theanine on intestinal nutrients absorption were investigated using rats ingesting L-theanine solution (0, 50, 200, and 400 mg/kg body weight) per day for two weeks. The decline of insulin secretion and glucose concentration in the serum was observed by L-theanine. Urea and high-density lipoprotein were also reduced by 50 mg/kg L-theanine. Jejunal and ileac basic amino acids transporters SLC7a1 and SLC7a9, neutral SLC1a5 and SLC16a10, and acidic SLC1a1 expression were upregulated...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28801632/stimulation-in-primary-and-secondary-metabolism-by-elevated-carbon-dioxide-alters-green-tea-quality-in-camellia-sinensis-l
#14
Xin Li, Lan Zhang, Golam Jalal Ahammed, Zhi-Xin Li, Ji-Peng Wei, Chen Shen, Peng Yan, Li-Ping Zhang, Wen-Yan Han
Rising CO2 concentration, a driving force of climate change, is impacting global food security by affecting plant physiology. Nevertheless, the effects of elevated CO2 on primary and secondary metabolism in tea plants (Camellia sinensis L.) still remain largely unknown. Here we showed that exposure of tea plants to elevated CO2 (800 µmol mol(-1) for 24 d) remarkably improved both photosynthesis and respiration in tea leaves. Furthermore, elevated CO2 increased the concentrations of soluble sugar, starch and total carbon, but decreased the total nitrogen concentration, resulting in an increased carbon to nitrogen ratio in tea leaves...
August 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28796499/studies-on-the-biochemical-formation-pathway-of-the-amino-acid-l-theanine-in-tea-camellia-sinensis-and-other-plants
#15
Sihua Cheng, Xiumin Fu, Xiaoqin Wang, Yinyin Liao, Lanting Zeng, Fang Dong, Ziyin Yang
Tea (Camellia sinensis) is the most widely consumed beverage aside from water. The flavor of tea is conferred by certain metabolites, especially l-theanine, in C. sinensis. To determine why more l-theanine accumulates in C. sinensis than in other plants, we compare l-theanine contents between C. sinensis and other plant species (Camellia nitidissima, Camellia japonica, Zea mays, Arabidopsis thaliana, and Solanum lycopersicum) and use a stable isotope labeling approach to elucidate its biosynthetic route. We quantify relevant intermediates and metabolites by mass spectrometry...
August 23, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28764024/does-oolong-tea-camellia-sinensis-made-from-a-combination-of-leaf-and-stem-smell-more-aromatic-than-leaf-only-tea-contribution-of-the-stem-to-oolong-tea-aroma
#16
Lanting Zeng, Ying Zhou, Xiumin Fu, Xin Mei, Sihua Cheng, Jiadong Gui, Fang Dong, Jinchi Tang, Shengzhou Ma, Ziyin Yang
The raw materials used to make oolong tea (Camellia sinensis) are a combination of leaf and stem. Oolong tea made from leaf and stem is thought to have a more aromatic smell than leaf-only tea. However, there is no available evidence to support the viewpoint. In this study, sensory evaluation and detailed characterization of emitted and internal volatiles (not readily emitted, but stored in samples) of dry oolong teas and infusions indicated that the presence of stem did not significantly improve the total aroma characteristics...
December 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28753943/reduced-stress-and-improved-sleep-quality-caused-by-green-tea-are-associated-with-a-reduced-caffeine-content
#17
Keiko Unno, Shigenori Noda, Yohei Kawasaki, Hiroshi Yamada, Akio Morita, Kazuaki Iguchi, Yoriyuki Nakamura
Caffeine, one of the main components in green tea, can interfere with sleep and block the effect of theanine. Since theanine, the main amino acid in tea leaves, has significant anti-stress effects in animals and humans, we examined the effects of green tea with lowered caffeine content, i.e., low-caffeine green tea (LCGT), on stress and quality of sleep of middle-aged individuals (n = 20, mean age 51.3 ± 6.7 years) in a double-blind crossover design. Standard green tea (SGT) was used as the control. These teas (≥300 mL/day), which were eluted with room temperature water, were consumed over a period of seven days after a single washout term...
July 19, 2017: Nutrients
https://www.readbyqxmd.com/read/28744294/transcriptome-profiling-using-single-molecule-direct-rna-sequencing-approach-for-in-depth-understanding-of-genes-in-secondary-metabolism-pathways-of-camellia-sinensis
#18
Qingshan Xu, Junyan Zhu, Shiqi Zhao, Yan Hou, Fangdong Li, Yuling Tai, Xiaochun Wan, ChaoLing Wei
Characteristic secondary metabolites, including flavonoids, theanine and caffeine, are important components of Camellia sinensis, and their biosynthesis has attracted widespread interest. Previous studies on the biosynthesis of these major secondary metabolites using next-generation sequencing technologies limited the accurately prediction of full-length (FL) splice isoforms. Herein, we applied single-molecule sequencing to pooled tea plant tissues, to provide a more complete transcriptome of C. sinensis. Moreover, we identified 94 FL transcripts and four alternative splicing events for enzyme-coding genes involved in the biosynthesis of flavonoids, theanine and caffeine...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28722219/preparation-and-evaluation-of-tert-leucine-derivative-functionalized-polymeric-monoliths-for-micro-liquid-chromatography
#19
Meng Ruan, Qiqin Wang, Huihui Wu, Yuqiang Wang, Hai Han, Zhengjin Jiang
In this study, a novel functional monomer N-[1-(α-naphthyl)ethylaminocarbonyl]-D-tert-leucine-[2-(methacryloyloxy)ethyl] amide (NA-D-tert-Leu-MA) was synthesized, and then employed to prepare polymeric monoliths (240 mm × 100 μm id) functionalized with tert-leucine derivative through a single step thermo-initiated co-polymerization approach or a multi-step post-modification approach. The multi-step approach involves the post-modification of a thiol-containing monolith with NA-D-tert-Leu-MA via "thiol-ene"click reaction...
July 19, 2017: Electrophoresis
https://www.readbyqxmd.com/read/28640307/healthy-properties-of-green-and-white-teas-an-update
#20
S Pastoriza, M Mesías, C Cabrera, J A Rufián-Henares
Green tea has been consumed for centuries in Japan, China and Morocco. White tea, which is considered a variety of green tea, is mostly consumed in China and is very appreciated for its flavor. Currently the consumption of both types of tea has been extended to the western countries even as a functional ingredient. A group of polyphenols called catechins stands out among their bioactive components, the most abundant being the (-) epigallocatechin gallate, with high antioxidant power. Teas also contain other phenolic compounds such as gallic, caffeic, chlorogenic or cinnamic acids, quercetin and proanthocyanidols, caffeine, theophylline, l-theanine and minerals such as fluorine, manganese or chromium...
August 1, 2017: Food & Function
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