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https://www.readbyqxmd.com/read/28330526/different-spectrophotometric-and-chromatographic-methods-for-determination-of-mepivacaine-and-its-toxic-impurity
#1
Nada S Abdelwahab, Nehal F Fared, Mohamed Elagawany, Esraa H Abdelmomen
Stability-indicating spectrophotometric, TLC-densitometric, and ultra-performance LC (UPLC) methods were developed forthe determination of mepivacaine HCl (MEP) in the presence of its toxic impurity, 2,6-dimethylanaline (DMA). Different spectrophotometric methods were developed for the determination of MEP and DMA. In a dual-wavelength method combined with direct spectrophotometric measurement, the absorbance difference between 221.4 and 240 nm was used for MEP measurements, whereas the absorbance at 283 nm was used for measuring DMA in the binary mixture...
February 21, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28328524/paramagnetic-micro-particles-as-a-tool-for-rapid-quantification-of-apixaban-dabigatran-edoxaban-and-rivaroxaban-in-human-plasma-by-uhplc-ms-ms
#2
Martin H J Wiesen, Cornelia Blaich, Thomas Streichert, Guido Michels, Carsten Müller
BACKGROUND: Assessment of the anticoagulant activity of direct oral anticoagulants (DOACs) is justified in special clinical situations. Here, we evaluated two independent extraction methods and developed a multi-analyte ultra-high performance liquid chromatography tandem mass (UHPLC-MS/MS) method for the quantification of apixaban, dabigatran, edoxaban and rivaroxaban in human plasma. METHODS: Routine extraction based on protein precipitation with acetonitrile and subsequent centrifugation was compared to sample clean-up using commercial paramagnetic micro-particles and subsequent magnetic depletion...
March 22, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28322630/energy-macronutrient-and-water-intake-during-a-mountain-ultramarathon-event-the-influence-of-distance
#3
Sonia Martinez, Antoni Aguilo, Lluis Rodas, Leticia Lozano, Carlos Moreno, Pedro Tauler
Adequate dietary strategies are essential for the successful participation in ultra-endurance races. The aim of this study was to evaluate and compare the energy and water intakes of participants during three different mountain ultra-endurance runs. The study took place at the "Ultra Mallorca Serra de Tramuntana" (Mallorca, Spain), an ultra-endurance mountain event with runners participating either in a 44-km (Marathon, n = 51), a 67-km (Trail, n = 109) or a 112-km (Ultra, n = 53) run competition. Participants in the study answered a questionnaire focused on the nutritional intake within an hour after finishing the competition...
March 21, 2017: Journal of Sports Sciences
https://www.readbyqxmd.com/read/28321965/robust-presurgical-functional-mri-at-7-t-using-response-consistency
#4
Pedro Lima Cardoso, Florian Ph S Fischmeister, Barbara Dymerska, Alexander Geißler, Moritz Wurnig, Siegfried Trattnig, Roland Beisteiner, Simon Daniel Robinson
Functional MRI is valuable in presurgical planning due to its non-invasive nature, repeatability, and broad availability. Using ultra-high field MRI increases the specificity and sensitivity, increasing the localization reliability and reducing scan time. Ideally, fMRI analysis for this application should identify unreliable runs and work even if the patient deviates from the prescribed task timing or if there are changes to the hemodynamic response due to pathology. In this study, a model-free analysis method-UNBIASED-based on the consistency of fMRI responses over runs was applied, to ultra-high field fMRI localizations of the hand area...
March 21, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28303338/blood-glucose-kinetics-and-physiological-changes-in-a-type-1-diabetic-finisher-of-the-ultraman-triathlon-a-case-study
#5
Christopher W Bach, Daniel A Baur, William S Hyder, Michael J Ormsbee
PURPOSE: To investigate the blood glucose kinetics and physiological effects experienced by a type 1 diabetic (T1D) finisher of a 3-day, multi-stage ultra endurance triathlon consisting of a 10 km swim and 144.8 km bike (stage 1), a 275.4 km bike (stage 2), and an 84.4 km run (stage 3). METHODS: The athlete self-monitored blood glucose (SMBG) levels via fingerstick blood draw and hand-held glucometer. Researchers evaluated blood glucose kinetics via a continuous glucose monitoring device...
March 16, 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/28302972/sequential-injection-chromatography-with-an-ultra-short-monolithic-column-for-the-low-pressure-separation-of-%C3%AE-tocopherol-and-%C3%AE-oryzanol-in-vegetable-oils-and-nutrition-supplements
#6
Sujitra Thaithet, Supaporn Kradtap Hartwell, Somchai Lapanantnoppakhun
A low-pressure separation procedure of α-tocopherol and γ-oryzanol was developed based on a sequential injection chromatography (SIC) system coupled with an ultra-short (5 mm) C-18 monolithic column, as a lower cost and more compact alternative to the HPLC system. A green sample preparation, dilution with a small amount of hexane followed by liquid-liquid extraction with 80% ethanol, was proposed. Very good separation resolution (Rs = 3.26), a satisfactory separation time (10 min) and a total run time including column equilibration (16 min) were achieved...
2017: Analytical Sciences: the International Journal of the Japan Society for Analytical Chemistry
https://www.readbyqxmd.com/read/28296307/physically-constrained-voxel-based-penalty-adaptation-for-ultra-fast-imrt-planning
#7
Niklas Wahl, Mark Bangert, Cornelis P Kamerling, Peter Ziegenhein, Gijsbert H Bol, Bas W Raaymakers, Uwe Oelfke
Conventional treatment planning in intensity-modulated radiation therapy (IMRT) is a trial-and-error process that usually involves tedious tweaking of optimization parameters. Here, we present an algorithm that automates part of this process, in particular the adaptation of voxel-based penalties within normal tissue. Thereby, the proposed algorithm explicitly considers a priori known physical limitations of photon irradiation. The efficacy of the developed algorithm is assessed during treatment planning studies comprising 16 prostate and 5 head and neck cases...
July 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28288784/development-and-validation-of-a-measurement-procedure-based-on-ultra-high-performance-liquid-chromatography-tandem-mass-spectrometry-for-simultaneous-measurement-of-%C3%AE-lactam-antibiotic-concentration-in-human-plasma
#8
Raül Rigo-Bonnin, Alba Ribera, Ariadna Arbiol-Roca, Sara Cobo-Sacristán, Ariadna Padullés, Òscar Murillo, Evelyn Shaw, Rosa Granada, Xosé L Pérez-Fernández, Fe Tubau, Pedro Alía
BACKGROUND: The administration of β-lactam antibiotics in continuous infusion could let optimize the pharmacokinetic/pharmacodynamic parameters, especially in the treatment of serious bacterial infections. In this context, and also due to variability in their plasmatic concentrations, therapeutic drug monitoring (TDM) may be useful to optimize dosing and, therefore, be useful for the clinicians. MATERIAL AND METHODS: We developed and validated a measurement procedure based on ultra-high performance liquid chromatography-tandem mass spectrometry for simultaneous measurement of amoxicillin, ampicillin, cloxacillin, piperacillin, cefepime, ceftazidime, cefuroxime, aztreonam and meropenem concentrations in plasma...
March 10, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28282421/comparison-of-vitality-states-of-finishers-and-withdrawers-in-trail-running-an-enactive-and-phenomenological-perspective
#9
Nadège Rochat, Denis Hauw, Roberta Antonini Philippe, Fabienne Crettaz von Roten, Ludovic Seifert
Studies on ultra-endurance suggest that during the races, athletes typically experience three vitality states (i.e., preservation, loss, and revival) at the phenomenological level. Nevertheless, how these states contribute to the management and outcome of performance remains unclear. The aim of this study was to determine whether and how the vitality states experienced by runners and their evolution during a trail race can be used to distinguish finishers from withdrawers. From an enactive and phenomenological framework, we processed enactive interviews and blog posts of race narratives...
2017: PloS One
https://www.readbyqxmd.com/read/28268405/wearable-ecg-platform-for-continuous-cardiac-monitoring
#10
S P Preejith, R Dhinesh, Jayaraj Joseph, Mohanasankar Sivaprakasam
An ultra-low power ECG platform for continuous and minimally intrusive monitoring for systems with minimal processing capabilities, is presented in this paper. The platform is capable of detecting abnormalities in the ECG signal by extracting and analyzing features related to various cardiac trends. The platform is built to continuously operate on any of the 12 leads and the presented work includes a single lead implementation that works on lead I or II. A single lead, wearable ECG patch that can detect rhythm based arrhythmias and continuously monitor beat-to-beat heart rate and respiratory rate has been developed...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28249525/note-a-temperature-stable-low-noise-transimpedance-amplifier-for-microcurrent-measurement
#11
Kai Xie, Xueyou Shi, Kai Zhao, Lixin Guo, Hanlu Zhang
Temperature stability and noise characteristics often run contradictory in microcurrent (e.g., pA-scale) measurement instruments because low-noise performance requires high-value resistors with relatively poor temperature coefficients. A low-noise transimpedance amplifier with high-temperature stability, which involves an active compensation mechanism to overcome the temperature drift mainly caused by high-value resistors, is presented. The implementation uses a specially designed R-2R compensating network to provide programmable current gain with extra-fine trimming resolution...
February 2017: Review of Scientific Instruments
https://www.readbyqxmd.com/read/28236460/phenolic-profiling-of-rooibos-using-off-line-comprehensive-normal-phase-countercurrent-chromatography%C3%A3-reversed-phase-liquid-chromatography
#12
Nico A Walters, André de Villiers, Elizabeth Joubert, Dalene de Beer
Limited performance of one dimensional chromatographic methods provides the incentive for the development of multidimensional chromatographic techniques for the analysis of complex mixtures. Rooibos (Aspalathus linearis) represents such a complex sample, containing a range of phenolic compounds that cannot be separated and identified using a single chromatographic technique within a reasonable run time. By implementing NP high performance countercurrent chromatography (NP-HPCCC) in the first dimension ((1)D) and RP ultra-high pressure LC (RP-UHPLC) in the second dimension ((2)D), a highly orthogonal (∼80%) off-line comprehensive two-dimensional separation of rooibos phenolic compounds was achieved in a total analysis time of 17h...
February 14, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28226575/wearable-ecg-platform-for-continuous-cardiac-monitoring
#13
S P Preejith, R Dhinesh, Jayaraj Joseph, Mohanasankar Sivaprakasam, S P Preejith, R Dhinesh, Jayaraj Joseph, Mohanasankar Sivaprakasam, R Dhinesh, Mohanasankar Sivaprakasam, S P Preejith, Jayaraj Joseph
An ultra-low power ECG platform for continuous and minimally intrusive monitoring for systems with minimal processing capabilities, is presented in this paper. The platform is capable of detecting abnormalities in the ECG signal by extracting and analyzing features related to various cardiac trends. The platform is built to continuously operate on any of the 12 leads and the presented work includes a single lead implementation that works on lead I or II. A single lead, wearable ECG patch that can detect rhythm based arrhythmias and continuously monitor beat-to-beat heart rate and respiratory rate has been developed...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28223873/development-and-validation-of-bioanalytical-uhplc-uv-method-for-simultaneous-analysis-of-unchanged-fenofibrate-and-its-metabolite-fenofibric-acid-in-rat-plasma-application-to-pharmacokinetics
#14
Rayan G Alamri, Kazi Mohsin, Ajaz Ahmad, Mohammad Raish, Fars K Alanazi
A simple, precise, selective and fast ultra-high performance liquid chromatography (UHPLC-UV) method has been developed and validated for the simultaneous determination of a lipid regulating agent fenofibrate and its metabolite fenofibric acid in rat plasma. The chromatographic separation was carried out on a reversed-phase Acquity® BEH C18 column using methanol-water (65:35, v/v) as the mobile phase. The isocratic flow was 0.3 ml/min with rapid run time of 2.5 min and UV detection was at 284 nm. The method was validated over a concentration range of 100-10000 ng/ml (r(2) ⩾ 0...
January 2017: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/28222005/a-modular-low-complexity-ecg-delineation-algorithm-for-real-time-embedded-systems
#15
Jose Manuel Bote, Joaquin Recas, Francisco Rincon, David Atienza, Roman Hermida
This work presents a new modular and lowcomplexity algorithm for the delineation of the different ECG waves (QRS, P and T peaks, onsets and end). Involving a reduced number of operations per second and having a small memory footprint, this algorithm is intended to perform realtime delineation on resource-constrained embedded systems. The modular design allows the algorithm to automatically adjust the delineation quality in run time to a wide range of modes and sampling rates, from a Ultra-low power mode when no arrhythmia is detected, in which the ECG is sampled at low frequency, to a complete High-accuracy delineation mode in which the ECG is sampled at high frequency and all the ECG fiducial points are detected, in case of arrhythmia...
February 17, 2017: IEEE Journal of Biomedical and Health Informatics
https://www.readbyqxmd.com/read/28197103/increases-in-brain-1-h-mr-glutamine-and-glutamate-signals-following-acute-exhaustive-endurance-exercise-in-the-rat
#16
Maciej Świątkiewicz, Michał Fiedorowicz, Jarosław Orzeł, Marlena Wełniak-Kamińska, Piotr Bogorodzki, Józef Langfort, Paweł Grieb
Objective: Proton magnetic resonance spectroscopy ((1)H-MRS) in ultra-high magnetic field can be used for non-invasive quantitative assessment of brain glutamate (Glu) and glutamine (Gln) in vivo. Glu, the main excitatory neurotransmitter in the central nervous system, is efficiently recycled between synapses and presynaptic terminals through Glu-Gln cycle which involves glutamine synthase confined to astrocytes, and uses 60-80% of energy in the resting human and rat brain. During voluntary or involuntary exercise many brain areas are significantly activated, which certainly intensifies Glu-Gln cycle...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28193401/multiresponse-optimization-of-a-uplc-method-for-the-simultaneous-determination-of-tryptophan-and-15-tryptophan-derived-compounds-using-a-box-behnken-design-with-a-desirability-function
#17
Widiastuti Setyaningsih, Irfan E Saputro, Ceferino A Carrera, Miguel Palma, Carmelo G Barroso
A Box-Behnken design was used in conjunction with multiresponse optimization based on the desirability function to carry out the simultaneous separation of tryptophan and 15 derivatives by Ultra Performance Liquid Chromatography. The gradient composition of the mobile phase and the flow rate were optimized with respect to the resolution of severely overlapping chromatographic peaks and the total run time. Two different stationary phases were evaluated (hybrid silica and a solid-core-based C18 column). The methods were validated and a suitable sensitivity was found for all compounds in the concentration range 1-100μgL(-1) (R(2)>0...
June 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28192758/ultra-high-performance-liquid-chromatography-tandem-mass-spectrometry-for-simple-and-simultaneous-quantification-of-cannabinoids
#18
Rohitash Jamwal, Ariel R Topletz, Bharat Ramratnam, Fatemeh Akhlaghi
Cannabis is used widely in the United States, both recreationally and for medical purposes. Current methods for analysis of cannabinoids in human biological specimens rely on complex extraction process and lengthy analysis time. We established a rapid and simple assay for quantification of Δ(9)-tetrahydrocannabinol (THC), cannabidiol (CBD), 11-hydroxy Δ(9)-tetrahydrocannabinol (11-OH THC) and 11-nor-9-carboxy-Δ(9)-tetrahydrocannbinol (THCCOOH) in human plasma by U-HPLC-MS/MS usingΔ9-tetrahydrocannabinol-D3 (THC-D3) as the internal standard...
March 24, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28188893/ultra-deep-next-generation-mitochondrial-genome-sequencing-reveals-widespread-heteroplasmy-in-chinese-hamster-ovary-cells
#19
Paul S Kelly, Colin Clarke, Alan Costello, Craig Monger, Justine Meiller, Heena Dhiman, Nicole Borth, Michael J Betenbaugh, Martin Clynes, Niall Barron
Recent sequencing of the Chinese hamster ovary (CHO) cell and Chinese hamster genomes has dramatically advanced our ability to understand the biology of these mammalian cell factories. In this study, we focus on the powerhouse of the CHO cell, the mitochondrion. Utilizing a high-resolution next generation sequencing approach we sequenced the Chinese hamster mitochondrial genome for the first time and surveyed the mutational landscape of CHO cell mitochondrial DNA (mtDNA). Depths of coverage ranging from ~3,319X to 8,056X enabled accurate identification of low frequency mutations (>1%), revealing that mtDNA heteroplasmy is widespread in CHO cells...
February 8, 2017: Metabolic Engineering
https://www.readbyqxmd.com/read/28178765/enantioselective-analysis-of-citalopram-and-demethylcitalopram-in-human-whole-blood-by-chiral-lc-ms-ms-and-application-in-forensic-cases
#20
Sys Stybe Johansen
Citalopram is one of the most frequently used antidepressants in Denmark. Citalopram is marketed as a racemic mixture (50:50) of S- and R-enantiomers as well as of the S-enantiomer alone, which is the active enantiomer named escitalopram that processes the inhibitory effects. In this study, a chiral liquid chromatography-tandem mass spectrometry (LC-MS/MS) method is developed for the measurement of citalopram and demethylcitalopram enantiomers in whole blood and is applied to forensic cases. Whole blood samples (0...
February 8, 2017: Drug Testing and Analysis
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