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https://www.readbyqxmd.com/read/27915112/a-wavelet-filtering-method-for-cumulative-gamma-spectroscopy-used-in-wear-measurements
#1
Davide Bianchi, Claudia Lenauer, Gerhard Betz, András Vernes
Continuous ultra-mild wear quantification using radioactive isotopes involves measuring very low amounts of activity in limited time intervals. This results in gamma spectra with poor signal-to-noise ratio and hence very scattered wear data, especially during running-in, where wear is intrinsically low. Therefore, advanced filtering methods reducing the wear data scattering and making the calculation of the main peak area more accurate are mandatory. An energy-time dependent threshold for wavelet detail coefficients based on Poisson statistics and using a combined Barwell law for the estimation of the average photon counting rate is then introduced...
November 26, 2016: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/27895900/nutritional-implications-for-ultra-endurance-walking-and-running-events
#2
REVIEW
Eric Williamson
This paper examines the various nutritional challenges which athletes encounter in preparing for and participating in ultra-endurance walking and running events. Special attention is paid to energy level, performance, and recovery within the context of athletes' intake of carbohydrate, protein, fat, and various vitamins and minerals. It outlines, by way of a review of literature, those factors which promote optimal performance for the ultra-endurance athlete and provides recommendations from multiple researchers concerned with the nutrition and performance of ultra-endurance athletes...
2016: Extreme Physiology & Medicine
https://www.readbyqxmd.com/read/27877137/an-extreme-mountain-ultra-marathon-decreases-the-cost-of-uphill-walking-and-running
#3
Gianluca Vernillo, Aldo Savoldelli, Spyros Skafidas, Andrea Zignoli, Antonio La Torre, Barbara Pellegrini, Guido Giardini, Pietro Trabucchi, Grégoire P Millet, Federico Schena
Purpose: To examine the effects of the world's most challenging mountain ultramarathon (MUM, 330 km, cumulative elevation gain of +24,000 m) on the energy cost and kinematics of different uphill gaits. Methods: Before (PRE) and immediately after (POST) the competition, 19 male athletes performed three submaximal 5-min treadmill exercise trials in a randomized order: walking at 5 km·h(-1), +20%; running at 6 km·h(-1), +15%; and running at 8 km·h(-1), +10%. During the three trials, energy cost was assessed using an indirect calorimetry system and spatiotemporal gait parameters were acquired with a floor-level high-density photoelectric cells system...
2016: Frontiers in Physiology
https://www.readbyqxmd.com/read/27868222/adaptive-partitioning-by-local-density-peaks-an-efficient-density-based-clustering-algorithm-for-analyzing-molecular-dynamics-trajectories
#4
Song Liu, Lizhe Zhu, Fu Kit Sheong, Wei Wang, Xuhui Huang
We present an efficient density-based adaptive-resolution clustering method APLoD for analyzing large-scale molecular dynamics (MD) trajectories. APLoD performs the k-nearest-neighbors search to estimate the density of MD conformations in a local fashion, which can group MD conformations in the same high-density region into a cluster. APLoD greatly improves the popular density peaks algorithm by reducing the running time and the memory usage by 2-3 orders of magnitude for systems ranging from alanine dipeptide to a 370-residue Maltose-binding protein...
January 30, 2017: Journal of Computational Chemistry
https://www.readbyqxmd.com/read/27866173/a-rapid-uplc-ms-ms-assay-for-the-simultaneous-measurement-of-fluconazole-voriconazole-posaconazole-itraconazole-and-hydroxyitraconazole-concentrations-in-serum
#5
Sankha S Basu, Athena Petrides, Donald S Mason, Petr Jarolim
BACKGROUND: Triazole antifungals are essential to the treatment and prophylaxis of fungal infections. Significant pharmacokinetic variability combined with a clinical need for faster turnaround times has increased demand for in-house therapeutic drug monitoring of these drugs, which is best performed using mass spectrometry-based platforms. However, technical and logistical obstacles to implementing these platforms in hospital laboratories have limited their widespread utilization. Here, we present the development and validation of a fast and simple ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method to measure fluconazole, voriconazole, posaconazole, itraconazole, and hydroxyitraconazole in human serum suitable for incorporation into a hospital clinical laboratory...
November 21, 2016: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/27861316/development-of-an-uhplc-uv-method-for-quantification-of-direct-oral-anticoagulants-apixaban-rivaroxaban-dabigatran-and-its-prodrug-dabigatran-etexilate-in-human-serum
#6
Sebastian Boehr, Ekkehard Haen
BACKGROUND: Direct oral anticoagulants (DOACs) currently have no indication for monitoring even though there are data that imply that individual dosing can improve and add safety to the therapy. METHODS: An ultra-high performance liquid chromatography (UHPLC) method with ultra violet (UV) detection has been developed and validated for apixaban, dabigatran, dabigatran etexilate, and rivaroxaban. Protein precipitation with methanol (1:3 vol/vol) was used as sample preparation...
November 16, 2016: Therapeutic Drug Monitoring
https://www.readbyqxmd.com/read/27812041/strand-exchange-nucleic-acid-circuitry-with-enhanced-thermo-and-structure-buffering-abilities-turns-gene-diagnostics-ultra-reliable-and-environmental-compatible
#7
Zhentong Zhu, Yidan Tang, Yu Sherry Jiang, Sanchita Bhadra, Yan Du, Andrew D Ellington, Bingling Li
Catalytic hairpin assembly (CHA) is one of the most promising nucleic acid amplification circuits based on toehold-mediated strand exchange reactions. But its performance is usually ruined by fluctuated environmental temperatures or unexpected self-structures existing in most real-world targets. Here we present an amide-assistant mechanism that successfully reduces the prevalence of these problems for CHA and maximizes its thermo- and structure- buffering abilities. Such an organic amide-promoted CHA (shortened as OHT-CHA) can unprecedentedly amplify through 4 °C to 60 °C without rebuilding sequences or concerning target complexity...
November 4, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27805636/ultra-stable-high-average-power-femtosecond-laser-system-tunable-from-1-33-to-20%C3%A2-%C3%A2-%C3%AE-m
#8
Tobias Steinle, Florian Mörz, Andy Steinmann, Harald Giessen
A highly stable 350 fs laser system with a gap-free tunability from 1.33 to 2.0 μm and 2.13 to 20 μm is demonstrated. Nanojoule-level pulse energy is achieved in the mid-infrared at a 43 MHz repetition rate. The system utilizes a post-amplified fiber-feedback optical parametric oscillator followed by difference frequency generation between the signal and idler. No locking or synchronization electronics are required to achieve outstanding free-running output power and spectral stability of the whole system...
November 1, 2016: Optics Letters
https://www.readbyqxmd.com/read/27795912/profiling-of-ginsenosides-in-the-two-medicinal-panax-herbs-based-on-ultra-performance-liquid-chromatography-electrospray-ionization-mass-spectrometry
#9
Jia Liu, Yang Liu, Long Zhao, Zhong-Hua Zhang, Zhong-Hua Tang
As the king of herb plants, ginseng has been used for nearly 5000 years in medicines in Asia and recently in the West. Ginsenosides, the main active constituents in Panax herbs, have prominent immunoregulatory effects. Although extensively studied in the roots, ginsenosides have not been studied with regard to their profiles and natural variations in the leaf, stem, petiole, lateral root, and main roots during development or among species. In this study, a sensitive ultra-performance liquid chromatography-electrospray ionization-mass spectrometry method with a shorter chromatographic running time was developed and validated for simultaneous quantification of ten ginsenosides...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27789190/quantitative-analysis-of-organophosphate-insecticide-metabolites-in-urine-extracted-from-disposable-diapers-of-toddlers-in-japan
#10
Naoko Oya, Yuki Ito, Keisuke Hioki, Yuya Asai, Arisa Aoi, Yuka Sugiura, Jun Ueyama, Tomoko Oguri, Sayaka Kato, Takeshi Ebara, Michihiro Kamijima
BACKGROUND AND AIM: Epidemiological studies linking insecticide exposure to childhood neurodevelopment have been gaining global attention. Despite the rapid development of the central nervous system in early childhood, studies regarding the biological monitoring of insecticide exposure in diapered children are limited. In this study, we aimed to clarify the concentrations of organophosphate (OP) insecticide metabolites in toddler urine extracted from disposable diapers in Japan. METHODS: We recruited diapered children from the Aichi regional subcohort participants of the Japan Environment and Children's Study (JECS) at the time of their 18-month checkup...
October 20, 2016: International Journal of Hygiene and Environmental Health
https://www.readbyqxmd.com/read/27787469/running-performance-nationality-sex-and-age-in-10km-half-marathon-marathon-and-100km-ultra-marathon-iaaf-1999-2015
#11
Pantelis T Nikolaidis, Vincent O Onywera, Beat Knechtle
The aim of the present study was to examine the performance of the world's best runners in 10km, half-marathon, marathon and 100km by age, sex and nationality during 1999-2015 using data from International Association of Athletics Federations (IAAF). A total of 38,895 runners (17,136 women and 21,759 men) were considered with 2,594 (1,360 women and 1,234 male) in 10km, 11,595 (5,225 women and 6,370 male) in half-marathon, 23,973 (10,208 women and 13,765 male) in marathon and 733 (343 women and 390 male) in 100km...
October 13, 2016: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/27779285/-prognostic-modelling-and-proactive-intervention-in-psychosis-efficacy-and-cost-effectiveness
#12
M van der Gaag, H Ising, J Lokkerbol, F Smit
Diagnoses have heterogeneous outcomes, varying from good to extremely poor. There is a need to single out an ultra-high-risk group of individuals who have illnesses that might well end unfavourably or who might later develop serious psychopathology.<br/> AIM: To devise a screening instrument that can identify a group of individuals who run a very high risk of developing a first-episode psychosis, and to create a type of intervention that can modify the course of the illness.<br/> METHOD: We developed a short screening instrument (PQ-16) and were able to ascertain its predictive value...
2016: Tijdschrift Voor Psychiatrie
https://www.readbyqxmd.com/read/27770784/effects-of-two-neuromuscular-training-programs-on-running-biomechanics-with-load-carriage-a-study-protocol-for-a-randomised-controlled-trial
#13
Bernard X W Liew, Susan Morris, Justin W L Keogh, Brendyn Appleby, Kevin Netto
BACKGROUND: In recent years, athletes have ventured into ultra-endurance and adventure racing events, which tests their ability to race, navigate, and survive. These events often require race participants to carry some form of load, to bear equipment for navigation and survival purposes. Previous studies have reported specific alterations in biomechanics when running with load which potentially influence running performance and injury risk. We hypothesize that a biomechanically informed neuromuscular training program would optimize running mechanics during load carriage to a greater extent than a generic strength training program...
October 22, 2016: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/27768506/changes-in-running-mechanics-during-a-six-hours-running-race
#14
Nicola Giovanelli, Paolo Taboga, Stefano Lazzer
PURPOSE: To investigate changes in running mechanics during a six hours running race. METHODS: Twelve ultra-runners (age: 41.9±5.8 years; body mass: 68.3±12.6 kg; stature: 1.72±0.09 m) were asked to run as many 874 m flat loops as possible in six hours. Running speed, contact (tc) and aerial (ta) times were measured in the first lap and every 30±2 minutes during the race. Peak vertical ground reaction force (Fmax), stride length (SL), vertical downward displacement of the centre of mass (Δz), leg length change (ΔL), vertical (kvert) and leg (kleg) stiffness were then estimated...
September 26, 2016: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/27765244/a-novel-isoflavone-profiling-method-based-on-uplc-pda-esi-ms
#15
Shuang Zhang, Zong-Ping Zheng, Mao-Mao Zeng, Zhi-Yong He, Guan-Jun Tao, Fang Qin, Jie Chen
A novel non-targeted isoflavone profiling method was developed using the diagnostic fragment-ion-based extension strategy, based on ultra-high performance liquid chromatography coupled with photo-diode array detector and electrospray ionization-mass spectrometry (UPLC-PDA-ESI-MS). 16 types of isoflavones were obtained in positive mode, but only 12 were obtained in negative mode due to the absence of precursor ions. Malonyldaidzin and malonylgenistin glycosylated at the 4'-O position or malonylated at the 4″-O position of glucose were indicated by their retention behavior and fragmentation pattern...
March 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/27757515/high-throughput-and-simultaneous-quantitative-analysis-of-homocysteine-methionine-cycle-metabolites-and-co-factors-in-blood-plasma-and-cerebrospinal-fluid-by-isotope-dilution-lc-ms-ms
#16
Seu Ping Guiraud, Ivan Montoliu, Laeticia Da Silva, Loïc Dayon, Antonio Núñez Galindo, John Corthésy, Martin Kussmann, Francois-Pierre Martin
The methionine cycle is a key pathway contributing to the regulation of human health, with well-established involvement in cardiovascular diseases and cognitive function. Changes in one-carbon cycle metabolites have also been associated with mild cognitive decline, vascular dementia, and Alzheimer's disease. Today, there is no single analytical method to monitor both metabolites and co-factors of the methionine cycle. To address this limitation, we here report for the first time a new method for the simultaneous quantitation of 17 metabolites in the methionine cycle, which are homocysteic acid, taurine, serine, cysteine, glycine, homocysteine, riboflavin, methionine, pyridoxine, cystathionine, pyridoxamine, S-adenosylhomocysteine, S-adenosylmethionine, betaine, choline, dimethylglycine, and 5-methyltetrahydrofolic acid...
October 18, 2016: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/27750404/targeted-and-non-targeted-drug-screening-in-whole-blood-by-uhplc-tof-ms-with-data-independent-acquisition
#17
Christian Brinch Mollerup, Petur Weihe Dalsgaard, Marie Mardal, Kristian Linnet
High-resolution mass spectrometry (HRMS) is widely used for the drug screening of biological samples in clinical and forensic laboratories. With the continuous addition of new psychoactive substances (NPS), keeping such methods updated is challenging. HRMS allows for combined targeted and non-targeted screening; first, peaks are identified by software algorithms, and identifications are based on reference standard data. Remaining unknown peaks are attempted identified with in silico and literature data. However, several thousand peaks remain where most are unidentifiable or uninteresting in drug screening...
October 17, 2016: Drug Testing and Analysis
https://www.readbyqxmd.com/read/27743864/continuous-operation-of-an-ultra-low-power-microcontroller-using-glucose-as-the-sole-energy-source
#18
Inyoung Lee, Takashi Sode, Noya Loew, Wakako Tsugawa, Christopher Robin Lowe, Koji Sode
An ultimate goal for those engaged in research to develop implantable medical devices is to develop mechatronic implantable artificial organs such as artificial pancreas. Such devices would comprise at least a sensor module, an actuator module, and a controller module. For the development of optimal mechatronic implantable artificial organs, these modules should be self-powered and autonomously operated. In this study, we aimed to develop a microcontroller using the BioCapacitor principle. A direct electron transfer type glucose dehydrogenase was immobilized onto mesoporous carbon, and then deposited on the surface of a miniaturized Au electrode (7mm(2)) to prepare a miniaturized enzyme anode...
September 28, 2016: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/27736691/ultra-high-performance-liquid-chromatography-with-ultraviolet-and-tandem-mass-spectrometry-for-simultaneous-determination-of-metabolites-in-purine-pathway-of-rat-plasma
#19
Jin-Jin Lu, Bing-Jie Jia, Lin Yang, Wen Zhang, Xin Dong, Ping Li, Jun Chen
It has been proved that the purine metabolic pathway has been implicated in various biological disorders including gout, diabetes, coronary heart diseases, and neurodegenerative diseases. The analysis of the purine metabolic pathway in organisms reveals important alterations under different physiological and pathological conditions, which contributes to the pathological study, diagnosis, and therapy of related diseases. In the present study, an ultra-high performance liquid chromatography with ultraviolet and tandem mass spectrometry (UHPLC-UV-MS/MS) method was developed for conducting the comprehensive analysis of the metabolite profiles of the purine pathway in rat plasma through a single analysis...
September 28, 2016: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/27723573/protective-effects-of-gtm-1-on-endoplasmic-reticulum-stress-induced-by-thapsgargin-in-rat-neurons
#20
Lijuan Zhang, Lina Wang, Run Wang, Yonghua Pan, Yuan Gao, Peng Fu
GTM-1 is a drug that reverses Alzheimer's Disease (AD) development specifically induced by thapsgargin (TG) and endoplasmic reticulum (ER) has been reported to be a pilot process that leads to AD formation. It is speculated that GTM-1 could also prohibit TG-induced ER stress. In this study, we utilized immuno-fluorescence to identify morphological changes in nucleus and transmission electron microscopy was used to observe neuronal ultra-structures. Moreover, expressions of GRP78, CHOP, Bcl-2 and cytochrome c were assessed using immuno-blotting, while calcium concentration was detected by fluorescence spectrometer...
October 7, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
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