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https://www.readbyqxmd.com/read/28087758/method-for-the-determination-of-carbonyl-compounds-in-e-cigarette-aerosols
#1
Jason W Flora, Celeste T Wilkinson, James W Wilkinson, Peter J Lipowicz, James A Skapars, Adam Anderson, John H Miller
Low levels of thermal degradation products such as carbonyls (formaldehyde, acetaldehyde, acrolein, crotonaldehyde) have been reported in e-cigarette aerosols. The collection and analysis of e-cigarette aerosol carbonyls are often adapted from methods developed for tobacco cigarette smoke. These methodologies are often not sensitive enough to detect low carbonyl levels in e-cigarette aerosols. One objective of this work was to develop and validate a rapid, selective and sensitive ultra-performance liquid chromatography with mass spectrometry method optimized for analysis of carbonyls in e-cigarette aerosols...
February 2017: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/28074669/implementation-of-a-novel-ultra-fast-metabolic-stability-analysis-method-using-exact-mass-tof-ms
#2
Joseph D Manna, Samantha J Richardson, Mehran F Moghaddam
AIM: Increasing numbers of compounds requiring stability data means highly optimized methods capable of rapid turnaround are desirable during early discovery. Materials and methods/results: An advanced, generic analytical workflow for metabolic stability has been developed that utilizing ballistic gradient LC (sub 1 min run times), exact mass TOF-MS (Waters Xevo-G2-XS Q-TOF) and automated data processing (Waters UNIFI software) allowed for rapid integration and interpretation of all data produced, eliminating the need for method development and manual processing...
January 11, 2017: Bioanalysis
https://www.readbyqxmd.com/read/28059397/accurate-frequency-referencing-for-fieldable-dual-comb-spectroscopy
#3
Gar-Wing Truong, Eleanor M Waxman, Kevin C Cossel, Esther Baumann, Andrew Klose, Fabrizio R Giorgetta, William C Swann, Nathan R Newbury, Ian Coddington
We describe a dual-comb spectrometer that can operate independently of laboratory-based rf and optical frequency references but is nevertheless capable of ultra-high spectral resolution, high SNR, and frequency-accurate spectral measurements. The instrument is based on a "bootstrapped" frequency referencing scheme in which short-term optical phase coherence between combs is attained by referencing each to a free-running diode laser, whilst high frequency resolution and long-term accuracy is derived from a stable quartz oscillator...
December 26, 2016: Optics Express
https://www.readbyqxmd.com/read/28018241/master-athletes-are-extending-the-limits-of-human-endurance
#4
REVIEW
Romuald Lepers, Paul J Stapley
The increased participation of master athletes (i.e., >40 years old) in endurance and ultra-endurance events (>6 h duration) over the past few decades has been accompanied by an improvement in their performances at a much faster rate than their younger counterparts. Aging does however result in a decrease in overall endurance performance. Such age-related declines in performance depend upon the modes of locomotion, event duration, and gender of the participant. For example, smaller age-related declines in cycling performance than in running and swimming have been documented...
2016: Frontiers in Physiology
https://www.readbyqxmd.com/read/28017680/circulating-levels-of-endocannabinoids-respond-acutely-to-voluntary-exercise-are-altered-in-mice-selectively-bred-for-high-voluntary-wheel-running-and-differ-between-the-sexes
#5
Zoe Thompson, Donovan Argueta, Theodore Garland, Nicholas DiPatrizio
The endocannabinoid system serves many physiological roles, including in the regulation of energy balance, food reward, and voluntary locomotion. Signaling at the cannabinoid type 1 receptor has been specifically implicated in motivation for rodent voluntary exercise on wheels. We studied four replicate lines of high runner (HR) mice that have been selectively bred for 81 generations based on average number of wheel revolutions on days five and six of a six-day period of wheel access. Four additional replicate lines are bred without regard to wheel running, and serve as controls (C) for random genetic effects that may cause divergence among lines...
December 22, 2016: Physiology & Behavior
https://www.readbyqxmd.com/read/27993773/egad-ultra-fast-functional-analysis-of-gene-networks
#6
Sara Ballouz, Melanie Weber, Paul Pavlidis, Jesse Gillis
: Evaluating gene networks with respect to known biology is a common task but often a computationally costly one. Many computational experiments are difficult to apply exhaustively in network analysis due to run-times. To permit high-throughput analysis of gene networks, we have implemented a set of very efficient tools to calculate functional properties in networks based on guilt-by-association methods. EGAD: ( E: xtending ' G: uilt-by- A: ssociation' by D: egree) allows gene networks to be evaluated with respect to hundreds or thousands of gene sets...
December 19, 2016: Bioinformatics
https://www.readbyqxmd.com/read/27987487/a-rapid-method-for-sensitive-profiling-of-folates-from-plant-leaf-by-ultra-performance-liquid-chromatography-coupled-to-tandem-quadrupole-mass-spectrometer
#7
M J I Shohag, Qianying Yang, Yanyan Wei, Jie Zhang, Farhana Zerin Khan, Michael Rychlik, Zhenli He, Xiaoe Yang
Previous published methods for the analysis of folates are time consuming because of lengthy sample extraction, clean-up and total running time. This study details the development and validation of a rapid, sensitive and robust method that combines a simple extraction step with ultra-performance liquid chromatography coupled to tandem quadrupole mass spectrometry. Here, we reported application of a tandem quadrupole mass spectrometer to analyze maximum seven vitamers of folate from plant origin. The analytical performance was evaluated by linearity, sensitivity, precision, recovery test and analysis of certified reference materials...
January 1, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/27925253/fast-and-sensitive-analysis-of-beta-blockers-by-ultra-highperformance-liquid-chromatography-coupled-with-ultrahigh-resolution-tof-mass-spectrometry
#8
Jana Tomková, Peter Ondra, Eva Kocianová, Jan Václavík
This paper presents a method for the determination of acebutolol, betaxolol, bisoprolol, metoprolol, nebivolol and sotalol in human serum by liquid-liquid extraction (LLE) and ultra-high-performance liquid chromatography coupled with ultra-high-resolution TOF mass spectrometry (UHPLC-UHR-TOF MS). After liquid-liquid extraction, beta blockers were separated on a reverse phase analytical column Acclaim RS 120 (100 × 2.1 mm, 2.2 µm). The total run time was 6 min for each sample. Linearity, limit of detection (LOD), limit of quantification (LOQ), matrix effects, specificity, precision, accuracy, recovery and sample stability were evaluated...
December 7, 2016: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/27923330/the-influence-of-race-length-on-arterial-compliance-following-an-ultra-endurance-marathon
#9
Alis Bonsignore, Shannon S D Bredin, Holly Wollmann, Barb Morrison, Andrew Jeklin, Lauren Buschmann, Josh Robertson, Elizabeth Jean Buckler, Duncan McGuinty, Mark S Rice, Darren E R Warburton
There is inconclusive evidence concerning the effects of routine participation in ultra-endurance events on cardiovascular disease (CVD) risk. Arterial compliance is a reliable, non-invasive, and effective tool for evaluating CVD risk. The purpose of this research was to examine if race length influences acute changes in arterial compliance following an ultra-marathon event. A total of 46 ultra-marathon runners were recruited including 21 participants (39.8 ± 8.3 years, 6 females) in the 80-km event and 25 participants (43...
December 7, 2016: European Journal of Sport Science
https://www.readbyqxmd.com/read/27915112/a-wavelet-filtering-method-for-cumulative-gamma-spectroscopy-used-in-wear-measurements
#10
Davide Bianchi, Claudia Lenauer, Gerhard Betz, András Vernes
Continuous ultra-mild wear quantification using radioactive isotopes involves measuring very low amounts of activity in limited time intervals. This results in gamma spectra with poor signal-to-noise ratio and hence very scattered wear data, especially during running-in, where wear is intrinsically low. Therefore, advanced filtering methods reducing the wear data scattering and making the calculation of the main peak area more accurate are mandatory. An energy-time dependent threshold for wavelet detail coefficients based on Poisson statistics and using a combined Barwell law for the estimation of the average photon counting rate is then introduced...
February 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/27895900/nutritional-implications-for-ultra-endurance-walking-and-running-events
#11
REVIEW
Eric Williamson
This paper examines the various nutritional challenges which athletes encounter in preparing for and participating in ultra-endurance walking and running events. Special attention is paid to energy level, performance, and recovery within the context of athletes' intake of carbohydrate, protein, fat, and various vitamins and minerals. It outlines, by way of a review of literature, those factors which promote optimal performance for the ultra-endurance athlete and provides recommendations from multiple researchers concerned with the nutrition and performance of ultra-endurance athletes...
2016: Extreme Physiology & Medicine
https://www.readbyqxmd.com/read/27877137/an-extreme-mountain-ultra-marathon-decreases-the-cost-of-uphill-walking-and-running
#12
Gianluca Vernillo, Aldo Savoldelli, Spyros Skafidas, Andrea Zignoli, Antonio La Torre, Barbara Pellegrini, Guido Giardini, Pietro Trabucchi, Grégoire P Millet, Federico Schena
Purpose: To examine the effects of the world's most challenging mountain ultramarathon (MUM, 330 km, cumulative elevation gain of +24,000 m) on the energy cost and kinematics of different uphill gaits. Methods: Before (PRE) and immediately after (POST) the competition, 19 male athletes performed three submaximal 5-min treadmill exercise trials in a randomized order: walking at 5 km·h(-1), +20%; running at 6 km·h(-1), +15%; and running at 8 km·h(-1), +10%. During the three trials, energy cost was assessed using an indirect calorimetry system and spatiotemporal gait parameters were acquired with a floor-level high-density photoelectric cells system...
2016: Frontiers in Physiology
https://www.readbyqxmd.com/read/27868222/adaptive-partitioning-by-local-density-peaks-an-efficient-density-based-clustering-algorithm-for-analyzing-molecular-dynamics-trajectories
#13
Song Liu, Lizhe Zhu, Fu Kit Sheong, Wei Wang, Xuhui Huang
We present an efficient density-based adaptive-resolution clustering method APLoD for analyzing large-scale molecular dynamics (MD) trajectories. APLoD performs the k-nearest-neighbors search to estimate the density of MD conformations in a local fashion, which can group MD conformations in the same high-density region into a cluster. APLoD greatly improves the popular density peaks algorithm by reducing the running time and the memory usage by 2-3 orders of magnitude for systems ranging from alanine dipeptide to a 370-residue Maltose-binding protein...
January 30, 2017: Journal of Computational Chemistry
https://www.readbyqxmd.com/read/27866173/a-rapid-uplc-ms-ms-assay-for-the-simultaneous-measurement-of-fluconazole-voriconazole-posaconazole-itraconazole-and-hydroxyitraconazole-concentrations-in-serum
#14
Sankha S Basu, Athena Petrides, Donald S Mason, Petr Jarolim
BACKGROUND: Triazole antifungals are essential to the treatment and prophylaxis of fungal infections. Significant pharmacokinetic variability combined with a clinical need for faster turnaround times has increased demand for in-house therapeutic drug monitoring of these drugs, which is best performed using mass spectrometry-based platforms. However, technical and logistical obstacles to implementing these platforms in hospital laboratories have limited their widespread utilization. Here, we present the development and validation of a fast and simple ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method to measure fluconazole, voriconazole, posaconazole, itraconazole, and hydroxyitraconazole in human serum suitable for incorporation into a hospital clinical laboratory...
November 21, 2016: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/27861316/development-of-an-uhplc-uv-method-for-quantification-of-direct-oral-anticoagulants-apixaban-rivaroxaban-dabigatran-and-its-prodrug-dabigatran-etexilate-in-human-serum
#15
Sebastian Boehr, Ekkehard Haen
BACKGROUND: Direct oral anticoagulants (DOACs) currently have no indication for monitoring even though there are data that imply that individual dosing can improve and add safety to the therapy. METHODS: An ultra-high performance liquid chromatography (UHPLC) method with ultra violet (UV) detection has been developed and validated for apixaban, dabigatran, dabigatran etexilate, and rivaroxaban. Protein precipitation with methanol (1:3 vol/vol) was used as sample preparation...
November 16, 2016: Therapeutic Drug Monitoring
https://www.readbyqxmd.com/read/27812041/strand-exchange-nucleic-acid-circuitry-with-enhanced-thermo-and-structure-buffering-abilities-turns-gene-diagnostics-ultra-reliable-and-environmental-compatible
#16
Zhentong Zhu, Yidan Tang, Yu Sherry Jiang, Sanchita Bhadra, Yan Du, Andrew D Ellington, Bingling Li
Catalytic hairpin assembly (CHA) is one of the most promising nucleic acid amplification circuits based on toehold-mediated strand exchange reactions. But its performance is usually ruined by fluctuated environmental temperatures or unexpected self-structures existing in most real-world targets. Here we present an amide-assistant mechanism that successfully reduces the prevalence of these problems for CHA and maximizes its thermo- and structure- buffering abilities. Such an organic amide-promoted CHA (shortened as OHT-CHA) can unprecedentedly amplify through 4 °C to 60 °C without rebuilding sequences or concerning target complexity...
November 4, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27805636/ultra-stable-high-average-power-femtosecond-laser-system-tunable-from-1-33-to-20%C3%A2-%C3%A2-%C3%AE-m
#17
Tobias Steinle, Florian Mörz, Andy Steinmann, Harald Giessen
A highly stable 350 fs laser system with a gap-free tunability from 1.33 to 2.0 μm and 2.13 to 20 μm is demonstrated. Nanojoule-level pulse energy is achieved in the mid-infrared at a 43 MHz repetition rate. The system utilizes a post-amplified fiber-feedback optical parametric oscillator followed by difference frequency generation between the signal and idler. No locking or synchronization electronics are required to achieve outstanding free-running output power and spectral stability of the whole system...
November 1, 2016: Optics Letters
https://www.readbyqxmd.com/read/27795912/profiling-of-ginsenosides-in-the-two-medicinal-panax-herbs-based-on-ultra-performance-liquid-chromatography-electrospray-ionization-mass-spectrometry
#18
Jia Liu, Yang Liu, Long Zhao, Zhong-Hua Zhang, Zhong-Hua Tang
As the king of herb plants, ginseng has been used for nearly 5000 years in medicines in Asia and recently in the West. Ginsenosides, the main active constituents in Panax herbs, have prominent immunoregulatory effects. Although extensively studied in the roots, ginsenosides have not been studied with regard to their profiles and natural variations in the leaf, stem, petiole, lateral root, and main roots during development or among species. In this study, a sensitive ultra-performance liquid chromatography-electrospray ionization-mass spectrometry method with a shorter chromatographic running time was developed and validated for simultaneous quantification of ten ginsenosides...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27789190/quantitative-analysis-of-organophosphate-insecticide-metabolites-in-urine-extracted-from-disposable-diapers-of-toddlers-in-japan
#19
Naoko Oya, Yuki Ito, Keisuke Hioki, Yuya Asai, Arisa Aoi, Yuka Sugiura, Jun Ueyama, Tomoko Oguri, Sayaka Kato, Takeshi Ebara, Michihiro Kamijima
BACKGROUND AND AIM: Epidemiological studies linking insecticide exposure to childhood neurodevelopment have been gaining global attention. Despite the rapid development of the central nervous system in early childhood, studies regarding the biological monitoring of insecticide exposure in diapered children are limited. In this study, we aimed to clarify the concentrations of organophosphate (OP) insecticide metabolites in toddler urine extracted from disposable diapers in Japan. METHODS: We recruited diapered children from the Aichi regional subcohort participants of the Japan Environment and Children's Study (JECS) at the time of their 18-month checkup...
October 20, 2016: International Journal of Hygiene and Environmental Health
https://www.readbyqxmd.com/read/27787469/running-performance-nationality-sex-and-age-in-10km-half-marathon-marathon-and-100km-ultra-marathon-iaaf-1999-2015
#20
Pantelis T Nikolaidis, Vincent O Onywera, Beat Knechtle
The aim of the present study was to examine the performance of the world's best runners in 10km, half-marathon, marathon and 100km by age, sex and nationality during 1999-2015 using data from International Association of Athletics Federations (IAAF). A total of 38,895 runners (17,136 women and 21,759 men) were considered with 2,594 (1,360 women and 1,234 male) in 10km, 11,595 (5,225 women and 6,370 male) in half-marathon, 23,973 (10,208 women and 13,765 male) in marathon and 733 (343 women and 390 male) in 100km...
October 13, 2016: Journal of Strength and Conditioning Research
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