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JOURNAL ARTICLE
Eva-Maria Sunzel, Laura Rabinovich-Guilatt, Malini Iyengar, Debra Ruffo, Nagnath G Birajdar, Pippa Loupe, Maria Gutierrez, Mark Forrest Gordon, Giulia Ghibellini
Deutetrabenazine is approved for the treatment of tardive dyskinesia and chorea associated with Huntington's disease. This study compared the exposure between the once-daily (test) and twice-daily (reference) formulations of deutetrabenazine under fed conditions. Using a randomized crossover design, healthy adults (n = 262) received the 24 mg of the test formulation once daily and 12 mg of the reference formulation twice daily, each for 7 days. Plasma concentrations were collected on Days 4-6 before dose intake, and frequently for pharmacokinetic evaluation on Days 6 and 7 for determination of deutetrabenazine and active metabolites, deuterated α-dihydrotetrabenazine (α-HTBZ) and β-dihydrotetrabenazine (β-HTBZ)...
March 2024: Clinical Pharmacology in Drug Development
#22
JOURNAL ARTICLE
Matthew Guberman, Rimpy Dhingra, Jenna Cross, Victoria Margulets, Hongying Gang, Inna Rabinovich-Nikitin, Lorrie A Kirshenbaum
AIMS: The mitochondrial dynamics protein Mitofusin 2 (MFN2) coordinates critical cellular processes including mitochondrial bioenergetics, quality control, and cell viability. The NF-κB kinase IKKβ suppresses mitochondrial injury in doxorubicin cardiomyopathy, but the underlying mechanism is undefined. METHODS AND RESULTS: Herein, we identify a novel signalling axis that functionally connects IKKβ and doxorubicin cardiomyopathy to a mechanism that impinges upon the proteasomal stabilization of MFN2...
January 2, 2024: Cardiovascular Research
#23
JOURNAL ARTICLE
Suzanne C Li, C Egla Rabinovich, Mara L Becker, Kathryn S Torok, Polly J Ferguson, Fatma Dedeoglu, Sandy Hong, Vidya Sivaraman, Ronald M Laxer, Katie Stewart, Maria F Ibarra, Thomas Mason, Gloria Higgins, Elena Pope, Xiaohu Li, Tara Lozy, Robert C Fuhlbrigge
UNLABELLED: Juvenile localized scleroderma (jLS) is a chronic autoimmune disease commonly associated with poor outcome, including contractures, hemi-atrophy, uveitis, and seizures. Despite improvements in treatment, >25% of jLS patients have functional impairment. To improve patient evaluation, our workgroup developed Localized scleroderma Total Severity Scale (LoTSS), an overall disease severity measure. METHOD: LoTSS was developed as a weighted measure by a consensus process involving literature review, surveys, case vignettes, and multi-criteria decision analysis...
December 26, 2023: Arthritis Care & Research
#24
REVIEW
Federico Ferro, Renza Spelat, Abhay Pandit, José L Martin-Ventura, Gabriel A Rabinovich, Paolo Contessotto
Protein glycosylation controls cell-cell and cell-extracellular matrix (ECM) communication in immune, vascular, and inflammatory processes, underlining the critical role of this process in the identification of disease biomarkers and the design of novel therapies. Emerging evidence highlights the critical role of blood cell glycosylation in the pathophysiology of atherosclerosis (ATH) and myocardial infarction (MI). Here, we review the role of glycosylation in the interplay between blood cells, particularly erythrocytes, and endothelial cells (ECs), highlighting the involvement of this critical post/cotranslational modification in settings of cardiovascular disease (CVD)...
December 22, 2023: Trends in Molecular Medicine
#25
José M Ceresetto, Romina A López, Andrés R Humphreys, Cristina Duboscq, Oscar M Rabinovich, Nicholas C Emery, Astrid Rausch, Luis Zapata Tapia, Pablo Dezanzo, Pablo Young
Plasminogen deficiency is a very rare multisystem entity that affects different tissues of the economy through the deposition of fibrin-rich pseudomembrane and determines a heterogeneous and diverse clinical presentation. It is transmitted in an autosomal recessive manner by mutations of the PLG gene on chromosome 6 and can be divided into hypoplasminogenemia or type I and dysplasminogenemia or type II, the latter not related to clinical pathology. Severe plasminogen deficiency has a prevalence of 1.6 individuals per million inhabitants and although it can be diagnosed in adulthood, the most severe symptoms are observed in infants and children...
2023: Medicina
#26
JOURNAL ARTICLE
Dennis J Worm, Grzegorz J Grabe, Guilherme V de Castro, Sofya Rabinovich, Ian Warm, Kira Isherwood, Sophie Helaine, Anna Barnard
Bacterial toxin inhibition is a promising approach to overcoming antibiotic failure. In Salmonella , knockout of the toxin Doc has been shown to significantly reduce the formation of antibiotic-tolerant persisters. Doc is a kinase that is inhibited in nontolerant cells by its cognate antitoxin, Phd. In this work, we have developed first-in-class stapled peptide antitoxin mimetics based on the Doc inhibitory sequence of Phd. After making a series of substitutions to improve bacterial uptake, we identified a lead stapled Phd peptide that is able to counteract Doc toxicity in Salmonella ...
December 15, 2023: ACS Chemical Biology
#27
JOURNAL ARTICLE
Chunxiao Xu, Xueyuan Zhou, Lindsay Webb, Sireesha Yalavarthi, Wenxin Zheng, Somdutta Saha, Rene Schweickhardt, Maria Soloviev, Molly H Jenkins, Susanne Brandstetter, Natalya Belousova, Marat Alimzhanov, Brian Rabinovich, Amit M Deshpande, Neil Brewis, Laura Helming
The costimulatory receptor CD137 (also known as TNFRSF9 or 4-1BB) sustains effective cytotoxic T-cell responses. Agonistic anti-CD137 cancer immunotherapies are being investigated in clinical trials. Development of the first-generation CD137-agonist monotherapies utomilumab and urelumab was unsuccessful due to low antitumor efficacy mediated by the epitope recognized on CD137 or hepatotoxicity mediated by FcγR ligand-dependent CD137 activation, respectively. M9657 was engineered as a tetravalent bispecific antibody (mAb2 TM) in a human IgG1 backbone with LALA mutations to reduce binding to Fcγ receptors...
December 13, 2023: Cancer Immunology Research
#28
JOURNAL ARTICLE
Elishai Assayag, Hashem Totah, Elena Drabkin, Ehud Reich, Ronen Rabinovich, Daniel Rappoport
PURPOSE: To describe a rare case of acquired Brown syndrome (ABS) associated with acute rheumatic fever (ARF). CASE REPORT: a healthy 9-year-old girl developed polyarthritis, carditis, and elevated inflammatory markers 10 days after suffering from a sore throat. She was diagnosed with ARF and was treated with systemic antibiotics and high-dose non-steroidal anti-inflammatory drug (NSAID). After 2 weeks, despite improvement of ARF symptoms, the patient presented with binocular vertical diplopia, periorbital pain, and limited elevation in adduction of the left eye...
November 30, 2023: European Journal of Ophthalmology
#29
JOURNAL ARTICLE
Daniel Rabinovich
No abstract text is available yet for this article.
November 30, 2023: Nature Chemistry
#30
JOURNAL ARTICLE
Zulqurnain Sabir, Dumitru Baleanu, Sharifah E Alhazmi, Salem Ben Said
The current study shows a reliable stochastic computing heuristic approach for solving the nonlinear Rabinovich-Fabrikant model. This nonlinear model contains three ordinary differential equations. The process of stochastic computing artificial neural networks (ANNs) has been applied along with the competences of global heuristic genetic algorithm (GA) and local search active set (AS) methodologies, i.e., ANNs-GAAS. The construction of merit function is performed through the differential Rabinovich-Fabrikant model...
November 2023: Heliyon
#31
JOURNAL ARTICLE
Carlos Hernandez-Suarez, Jorge Rabinovich
By quantifying key life history parameters in populations, such as growth rate, longevity, and generation time, researchers and administrators can obtain valuable insights into its dynamics. Although point estimates of demographic parameters have been available since the inception of demography as a scientific discipline, the construction of confidence intervals has typically relied on approximations through series expansions or computationally intensive techniques. This study introduces the first mathematical expression for calculating confidence intervals for the aforementioned life history traits when individuals are unidentifiable and data are presented as a life table...
November 22, 2023: Theoretical Population Biology
#32
JOURNAL ARTICLE
I M Rabinovich, N B Petrukhina, E V Shikh, V M Polyakov, I V Sandler
PURPOSE OF THE STUDY: To study the effectiveness of using the drug Cholisal as part of the conservative treatment of chronic periodontitis. MATERIAL AND METHODS: We selected 100 patients aged 35 to 65 years of both sexes with a diagnosis of moderate chronic periodontitis in the acute phase with a periodontal pocket depth of 3.5-5 mm. Depending on the tactics of conservative treatment of CGP, patients were divided into two groups of 50 people. In the main group, in addition to standard treatment, the dental gel Cholisal was used, and in the control group, therapy was standard...
2023: Stomatologii︠a︡
#33
JOURNAL ARTICLE
Peripapillary hyperreflective ovoid mass-like structures and the retinal nerve fiber layer thinning.
Mark Rabinovich, Samia Seray, Francesca Amoroso, Charles Madar, Eric H Souied
AIM: We describe a report of three cases of bilateral Peripapillary Hyperreflective Ovoid Mass-Like Structures (PHOMS), their respective multimodal imaging, and retinal nerve fiber layer (RNFL) analysis over time. METHODS: We performed an elaborated multimodal imaging of three pediatric patients with PHOMS. We performed a visual acuity testing, followed by a biomicroscopic and fundus examination, an additional Optical Coherence Tomography (OCT), fundus autofluorescence (FAF), infra-red (IR), fluorescein angiography (FA), Scanning laser Ophtalmoscopy (SLO), and retro-mode imaging...
October 31, 2023: European Journal of Ophthalmology
#34
REVIEW
María F Troncoso, María T Elola, Ada G Blidner, Luciana Sarrias, María V Espelt, Gabriel A Rabinovich
Galectins, a family of evolutionarily conserved glycan-binding proteins, play key roles in diverse biological processes including tissue repair, adipogenesis, immune cell homeostasis, angiogenesis and pathogen recognition. Dysregulation of galectins and their ligands has been observed in a wide range of pathologic conditions including cancer, autoimmune inflammation, infection, fibrosis and metabolic disorders. Through protein-glycan or protein-protein interactions, these endogenous lectins can shape initiation, perpetuation and resolution of these processes, suggesting their potential roles in disease monitoring and treatment...
October 26, 2023: Journal of Biological Chemistry
#35
JOURNAL ARTICLE
Mustafa M Siddiq, Nicholas P Johnson, Yana Zorina, Arjun Singh Yadaw, Carlos A Toro, Jens Hansen, Vera Rabinovich, Sarah M Gregorich, Yuguang Xiong, Rosa E Tolentino, Sari S Hannila, Ehud Kaplan, Robert D Blitzer, Marie T Filbin, Christopher P Cardozo, Christopher L Passaglia, Ravi Iyengar
There are no known drugs or drug combinations that promote substantial central nervous system axonal regeneration after injury. We used systems pharmacology approaches to model pathways underlying axonal growth and identify a four-drug combination that regulates multiple subcellular processes in the cell body and axons using the optic nerve crush model in rats. We intravitreally injected agonists HU-210 (cannabinoid receptor-1) and IL-6 (interleukin 6 receptor) to stimulate retinal ganglion cells for axonal growth...
2023: Frontiers in Pharmacology
#36
EDITORIAL
Inna Rabinovich-Nikitin, Lorrie A Kirshenbaum
No abstract text is available yet for this article.
September 2023: JACC. Basic to Translational Science
#37
E Bartoli, E Devara, H Q Dang, R Rabinovich, R K Mathura, A Anand, B R Pascuzzi, J Adkinson, K R Bijanki, S A Sheth, B Shofty
The default mode network (DMN) is a widely distributed, intrinsic brain network thought to play a crucial role in internally-directed cognition. It subserves self-referential thinking, recollection of the past, mind wandering, and creativity. Knowledge about the electrophysiology underlying DMN activity is scarce, due to the difficulty to simultaneously record from multiple distant cortical areas with commonly-used techniques. The present study employs stereo-electroencephalography depth electrodes in 13 human patients undergoing monitoring for epilepsy, obtaining high spatiotemporal resolution neural recordings across multiple canonical DMN regions...
September 18, 2023: bioRxiv
#38
JOURNAL ARTICLE
Mora Massaro, Alejandro J Cagnoni, Francisco J Medrano, Juan M Pérez-Sáez, Shuay Abdullayev, Karima Belkhadem, Karina V Mariño, Antonio Romero, René Roy, Gabriel A Rabinovich
Galectins, a family of endogenous glycan-binding proteins, play crucial roles in a broad range of physiological and pathological processes. Galectin-1 (Gal-1), a proto-type member of this family, is overexpressed in several cancers and plays critical roles in tumor-immune escape, angiogenesis and metastasis. Thus, generation of high-affinity Gal-1 inhibitors emerges as an attractive therapeutic approach for a wide range of neoplastic conditions. Small-molecule carbohydrate inhibitors based on lactose (Lac) and N-acetyllactosamine (LacNAc) structures have been tested showing different results...
September 21, 2023: Bioorganic & Medicinal Chemistry
#39
JOURNAL ARTICLE
Lewis G Halsey, Vincent Careau, Philip N Ainslie, Heliodoro Alemán-Mateo, Lene F Andersen, Liam J Anderson, Leonore Arab, Issad Baddou, Linda Bandini, Kweku Bedu-Addo, Ellen E Blaak, Stephane Blanc, Alberto G Bonomi, Carlijn V C Bouten, Pascal Bovet, Soren Brage, Maciej S Buchowski, Nancy Butte, Stephan G Camps, Regian Casper, Graeme L Close, Lisa H Colbert, Jamie A Cooper, Richard Cooper, Prasangi Dabare, Sai Krupa Das, Peter S W Davies, Sanjoy Deb, Christine Delisle Nyström, William Dietz, Lara R Dugas, Simon Eaton, Ulf Ekelund, Asmaa El Hamdouchi, Sonja Entringer, Terrence Forrester, Barry W Fudge, Melanie Gillingham, Annelies H Goris, Michael Gurven, Hinke Haisma, Catherine Hambly, Daniel Hoffman, Marije B Hoos, Sumei Hu, Noorjehan Joonas, Annemiek Joosen, Peter Katzmarzyk, Kitty P Kempen, Misaka Kimura, William E Kraus, Wantanee Kriengsinyos, Rebecca Kuriyan, Robert F Kushner, Estelle V Lambert, Pulani Lanerolle, Christel L Larsson, Nader Lessan, Marie Löf, Corby Martin, Eric Matsiko, Gerwin A Meijer, James C Morehen, James P Morton, Aviva Must, Marian Neuheuser, Theresa A Nicklas, Robert M Ojiambo, Kirsi H Pietilainen, Yannis P Pitsiladis, Jacob Plange-Rhule, Guy Plasqui, Ross L Prentice, Roberto Rabinovich, Susan B Racette, David A Raichen, Eric Ravussin, Leanne Redman, John J Reilly, Rebecca Reynolds, Susan Roberts, Jennifer C Rood, Dulani Samaranayake, Luís B Sardinha, Albertine J Scuitt, Analiza M Silva, Srishti Sinha, Anders M Sjödin, Eric Stice, Albert Stunkard, Samuel S Urlacher, Mauro Eduardo Valencia, Giulio Valenti, Ludo M van Etten, Edgar A Van Mil, Jeanine A Verbunt, Jonathan C K Wells, George Wilson, Brian Wood, Tsukasa Yoshida, Xueying Zhang, Alexia Murphy-Alford, Cornelia Loechl, Amy Luke, Herman Pontzer, Jennifer Rood, Hiroyuki Sagayama, Klaas R Westerterp, William W Wong, Yosuke Yamada, John R Speakman
There is considerably greater variation in metabolic rates between men than between women, in terms of basal, activity and total (daily) energy expenditure (EE). One possible explanation is that EE is associated with male sexual characteristics (which are known to vary more than other traits) such as musculature and athletic capacity. Such traits might be predicted to be most prominent during periods of adolescence and young adulthood, when sexual behaviour develops and peaks. We tested this hypothesis on a large dataset by comparing the amount of male variation and female variation in total EE, activity EE and basal EE, at different life stages, along with several morphological traits: height, fat free mass and fat mass...
September 2023: Biology Letters
#40
JOURNAL ARTICLE
Mark Rabinovich, Olivia Zambrowski, Alexandra Miere, Rakia Bhouri, Eric Souied
AIM: We describe the ophthalmic manifestations of Neuropathy, ataxia, retinitis pigmentosa (NARP) syndrome in three related patients. METHODS: We examined a mother and her two children, who were carriers of the mt 8993T>G mutation. The mother, patient I, is the first known carrier within the family pedigree. Patients II and III are her children from a non-carrier father. NARP syndrome and the heteroplasmy levels were established prior to the first referral of the patients to the Ophthalmology department...
September 6, 2023: Ophthalmic Genetics
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