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https://www.readbyqxmd.com/read/29342870/biomarkers-of-progression-after-hiv-acute-early-infection-nothing-compares-to-cd4%C3%A2-%C2%BA-t-cell-count
#1
Gabriela Turk, Yanina Ghiglione, Macarena Hormanstorfer, Natalia Laufer, Romina Coloccini, Jimena Salido, César Trifone, María Julia Ruiz, Juliana Falivene, María Pía Holgado, María Paula Caruso, María Inés Figueroa, Horacio Salomón, Luis D Giavedoni, María de Los Ángeles Pando, María Magdalena Gherardi, Roberto Daniel Rabinovich, Pedro A Pury, Omar Sued
Progression of HIV infection is variable among individuals, and definition disease progression biomarkers is still needed. Here, we aimed to categorize the predictive potential of several variables using feature selection methods and decision trees. A total of seventy-five treatment-naïve subjects were enrolled during acute/early HIV infection. CD4⁺ T-cell counts (CD4TC) and viral load (VL) levels were determined at enrollment and for one year. Immune activation, HIV-specific immune response, Human Leukocyte Antigen (HLA) and C-C chemokine receptor type 5 (CCR5) genotypes, and plasma levels of 39 cytokines were determined...
January 13, 2018: Viruses
https://www.readbyqxmd.com/read/29260649/are-infants-less-than-6-months-of-age-a-neglected-group-for-anemia-prevention-in-low-income-countries
#2
Cinta Moraleda, Regina N Rabinovich, Pedro L Alonso, Clara Menéndez
Anemia is a major public health problem that affects mainly children, predominantly in low-income countries and most often due to iron deficiency (ID). Administration of iron supplements to prevent and treat ID anemia in malaria endemic areas has been controversial for decades; however, recent World Health Organization guidelines recommend universal iron supplementation for children in highly prevalent anemia settings, including those where malaria is endemic. However, infants younger than 6 months of age have been exempted from this recommendation because ID is not considered prevalent at this age and because of assumptions-without evidence-that they are protected from ID through breast milk...
December 18, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29251064/risk-of-hypoglycemia-during-insulin-infusion-directed-by-paper-protocol-versus-electronic-glycemic-management-system-in-critically-ill-patients-at-a-large-academic-medical-center
#3
Marina Rabinovich, Jessica Grahl, Emily Durr, Rita Gayed, Katleen Chester, Raymie McFarland, Barbara McLean
BACKGROUND: Insulin infusions are commonly utilized to control hyperglycemia in critically ill patients and decrease hyperglycemia associated complications. Safety concerns have been raised in trials evaluating methods of glycemic control regarding the incidence of hypoglycemia and its relationship to increased mortality. Electronic glycemic management systems (eGMS) may result in less variable blood glucose (BG) control and less hypoglycemia. This study aimed to compare BG control, time in target BG range, and the rate of hypoglycemia when critically ill patients were managed with an insulin infusion guided by paper-based protocol (PBP) versus eGMS...
December 1, 2017: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/29237307/oligohydramnios-is-an-independent-risk-factor-for-perinatal-morbidity-among-women-with-preeclampsia-who-delivered-preterm
#4
Alex Rabinovich, Keren Holtzman, Ilana Shoham-Vardi, Moshe Mazor, Offer Erez
PURPOSE: Determine the relationship between oligohydramnios and adverse maternal and neonatal outcomes in a unique cohort of preterm preeclamptic patients. MATERIALS AND METHODS: A retrospective matched case control study comparing 81 preterm parturients (28 0/7 and 36 6/7 weeks) with preeclampsia and oligohydramnios to 81 preterm preeclamptic patients with a normal amniotic fluid index (AFI). RESULTS: 4.8 percent of all our preterm preeclamptic patients had oligohydramnios...
December 13, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29215607/proteomic-and-functional-analysis-identifies-galectin-1-as-a-novel-regulatory-component-of-the-cytotoxic-granule-machinery
#5
Tiago Clemente, Narcisio J Vieira, Juan P Cerliani, Colin Adrain, Alexander Luthi, Mariana R Dominguez, Monica Yon, Fernanda C Barrence, Thalita B Riul, Richard D Cummings, Telma M Zorn, Sebastian Amigorena, Marcelo Dias-Baruffi, Maurício M Rodrigues, Seamus J Martin, Gabriel A Rabinovich, Gustavo P Amarante-Mendes
Secretory granules released by cytotoxic T lymphocytes (CTLs) are powerful weapons against intracellular microbes and tumor cells. Despite significant progress, there is still limited information on the molecular mechanisms implicated in target-driven degranulation, effector cell survival and composition and structure of the lytic granules. Here, using a proteomic approach we identified a panel of putative cytotoxic granule proteins, including some already known granule constituents and novel proteins that contribute to regulate the CTL lytic machinery...
December 7, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/29213082/features-of-electronic-and-lattice-mechanisms-of-transboundary-heat-transfer-in-multilayer-nanolaminate-tialn-ag-coatings
#6
A I Kovalev, D L Wainstein, V O Vakhrushev, R Gago, F Soldera, J L Endrino, G S Fox-Rabinovich, S Veldhuis
Plasmon resonance heterogeneities were identified and studied along Ag and TiAlN layers within a multilayer stack in nanolaminate TiAlN/Ag coatings. For this purpose, a high-resolution plasmon microscopy was used. The plasmons intensity, energy, and depth of interface plasmon-polariton penetration were studied by scanning reflected electron energy loss spectroscopy. The heat conductivity of such metal-insulator-metal (MIM) nanolaminate coatings was measured by laser reflectometry. Dependencies of thermal conductivity coefficient of coatings, MIM interfaces, and resistivity of Ag layers as a function of the Ag-TiAlN bilayer thickness were calculated on the basis of experimental data...
December 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29193770/development-of-a-clinical-prediction-model-for-the-postthrombotic-syndrome-in-a-prospective-cohort-of-patients-with-proximal-deep-vein-thrombosis
#7
A Rabinovich, T Ducruet, S R Kahn
Essentials We developed a prediction model for postthrombotic syndrome (PTS) after deep vein thrombosis (DVT). High risk predictors were iliac vein DVT, BMI>35 and moderate-severe Villalta category. Patients with a score ≥4 had an odds ratio of 5.9 (95% CI 2.1-16.6) for PTS. SOX-PTS score may select DVT patients for close monitoring or aggressive strategies to treat DVT. SUMMARY: Background Postthrombotic syndrome (PTS) is a chronic complication that develops in 20-50% of patients after deep vein thrombosis (DVT)...
November 28, 2017: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/29190300/malera-an-updated-research-agenda-for-malaria-elimination-and-eradication
#8
Regina N Rabinovich, Chris Drakeley, Abdoulaye A Djimde, B Fenton Hall, Simon I Hay, Janet Hemingway, David C Kaslow, Abdisalan Noor, Fredros Okumu, Richard Steketee, Marcel Tanner, Timothy N C Wells, Maxine A Whittaker, Elizabeth A Winzeler, Dyann F Wirth, Kate Whitfield, Pedro L Alonso
Achieving a malaria-free world presents exciting scientific challenges as well as overwhelming health, equity, and economic benefits. WHO and countries are setting ambitious goals for reducing the burden and eliminating malaria through the "Global Technical Strategy" and 21 countries are aiming to eliminate malaria by 2020. The commitment to achieve these targets should be celebrated. However, the need for innovation to achieve these goals, sustain elimination, and free the world of malaria is greater than ever...
November 2017: PLoS Medicine
https://www.readbyqxmd.com/read/29158348/galectin-1-a-jack-of-all-trades-in-the-resolution-of-acute-and-chronic-inflammation
#9
REVIEW
Victoria Sundblad, Luciano G Morosi, Jorge R Geffner, Gabriel A Rabinovich
Regulatory signals provide negative input to immunological networks promoting resolution of acute and chronic inflammation. Galectin-1 (Gal-1), a member of a family of evolutionarily conserved glycan-binding proteins, displays broad anti-inflammatory and proresolving activities by targeting multiple immune cell types. Within the innate immune compartment, Gal-1 acts as a resolution-associated molecular pattern by counteracting the synthesis of proinflammatory cytokines, inhibiting neutrophil trafficking, targeting eosinophil migration and survival, and suppressing mast cell degranulation...
December 1, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29137629/correction-to-molecular-surveillance-of-pfhrp2-and-pfhrp3-deletions-in-plasmodium-falciparum-isolates-from-mozambique
#10
Himanshu Gupta, Gloria Matambisso, Beatriz Galatas, Pau Cisteró, Lidia Nhamussua, Wilson Simone, Jane Cunningham, N Regina Rabinovich, Pedro Alonso, Francisco Saute, Pedro Aide, Alfredo Mayor
After publication of the article [1], it has been brought to our attention that two of the authors have had their names spelt incorrectly in the original publication. The eighth author should be "N. Regina Rabinovich" but was previously spelt as "N. Regina Rabinovitch". The tenth author should be "Francisco Saute" but was previously spelt as "Franciso Saute". The original version of this article has now been revised to include these corrections.
November 14, 2017: Malaria Journal
https://www.readbyqxmd.com/read/29102341/translation-to-spanish-and-validation-of-the-specific-saint-george-s-questionnaire-for-idiopathic-pulmonary-fibrosis
#11
Ignacio Capparelli, Martín Fernandez, Marcela Saadia Otero, Jimena Steimberg, María Brassesco, Ana Campobasso, Sandra Palacios, Fabian Caro, María Laura Alberti, Roberto A Rabinovich, Francisco Paulin
INTRODUCTION: Interstitial lung disease (ILD) is associated with low exercise tolerance, dyspnea, and decreased health-related quality of life (HRQL). Idiopathic pulmonary fibrosis (IPF) is one of the most prevalent in the group. A specific version of the Saint George's questionnaire (SGRQ-I) has been developed to quantify the HRQL of IPF patients. However, this tool is not currently validated in the Spanish language. The objective was to translate into Spanish and validate the specific Saint George's Respiratory Questionnaire for idiopathic pulmonary fibrosis (SGRQ-I)...
November 1, 2017: Archivos de Bronconeumología
https://www.readbyqxmd.com/read/29092731/bioequivalence-of-cyclobenzaprine-hydrochloride-extended-release-capsule-taken%C3%A2-intact-or-sprinkled-over-applesauce%C3%A2
#12
Liat Adar, William Zarycranski, Jill B Conner, Jeffrey Dragone, Lindsay Janka, Laura Rabinovich-Guilatt
OBJECTIVE: Difficulty swallowing pills can compromise pain control in painful musculoskeletal disorders. This open-label, 2-period crossover study assessed pharmacokinetics and safety of cyclobenzaprine extended-release (CER) 30-mg capsule contents sprinkled over applesauce compared with intact capsules in healthy subjects. MATERIALS AND METHODS: 32 subjects were randomized to treatment sequences AB or BA (A = single CER intact capsule; B = single CER capsule contents sprinkled over applesauce (15 mL))...
October 26, 2017: International Journal of Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29091714/first-evidence-of-ancient-deer-cervid-in-the-late-miocene-bira-formation-northern-israel
#13
Alexis Gabriel Rozenbaum, Dotan Shaked Gelband, Mordechai Stein, Henk K Mienis, Rivka Rabinovich
Despite the extensive geological and paleontological searches in the south Levant, no terrestrial fauna of late Neogene age was yet reported. Here, we report the first evidence of "ancient deer"-cervid in the late Miocene (Tortonian) lacustrine section of the Bira Formation at Hagal Stream, Jordan Valley, northern Israel. The section comprises rich assemblage of macrofauna fossils, mostly freshwater mollusks. The mammalian bone was discovered among the macrofauna fossils, and is described as an almost complete left humerus of an adult animal identified as an artiodactyls element probably of a cervid...
2017: PloS One
https://www.readbyqxmd.com/read/29068405/effect-of-built-up-edge-formation-during-stable-state-of-wear-in-aisi-304-stainless-steel-on-machining-performance-and-surface-integrity-of-the-machined-part
#14
Yassmin Seid Ahmed, German Fox-Rabinovich, Jose Mario Paiva, Terry Wagg, Stephen Clarence Veldhuis
During machining of stainless steels at low cutting -speeds, workpiece material tends to adhere to the cutting tool at the tool-chip interface, forming built-up edge (BUE). BUE has a great importance in machining processes; it can significantly modify the phenomenon in the cutting zone, directly affecting the workpiece surface integrity, cutting tool forces, and chip formation. The American Iron and Steel Institute (AISI) 304 stainless steel has a high tendency to form an unstable BUE, leading to deterioration of the surface quality...
October 25, 2017: Materials
https://www.readbyqxmd.com/read/29065147/developing-citizen-report-cards-for-primary-health-care-in-low-and-middle-income-countries-results-from-cognitive-interviews-in-rural-tajikistan
#15
Sebastian Bauhoff, Lila Rabinovich, Lauren A Mayer
Citizen report cards on health care providers have been identified as a potential means to increase citizen engagement, provider accountability and health systems performance. Research in high-income settings indicates that the wording, presentation and display of performance information are critical to achieve these goals. However, there are limited insights on developing effective report card designs for middle- and low-income settings. We conducted cognitive interviews to assess consumers' understanding, interpretation of and preferences for displaying information for a health care report card in rural Tajikistan...
2017: PloS One
https://www.readbyqxmd.com/read/29016880/evaluation-of-the-relative-intranasal-abuse-potential-of-a-hydrocodone-extended-release-tablet-formulated-with-abuse-deterrence-technology-in-nondependent-recreational-opioid-users
#16
Mary Bond, Kerri A Schoedel, Laura Rabinovich-Guilatt, Maciej Gasior, William Tracewell, Richard Malamut, Yuju Ma, Lynn R Webster
Objective: To assess the intranasal abuse potential of hydrocodone extended-release (ER) tablets developed with CIMA Abuse-Deterrence Technology compared with hydrocodone powder and hydrocodone bitartrate ER capsules (Zohydro ER, original formulation [HYD-OF]). Design: Single-dose, randomized, double-blind, quadruple-dummy, active- and placebo-controlled, crossover study. Setting: One US site. Subjects: Healthy, adult, nondependent, recreational opioid users...
June 14, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28991028/predictive-value-of-galectin-1-in-the-development-and-progression-of-hiv-associated-lymphoma
#17
Maja Ølholm Vase, Maja Ludvigsen, Knud Bendix, Stephen H Dutoit, Rikke Hjortebjerg, Irma Petruskevicius, Michael B Møller, Gitte Pedersen, Paul W Denton, Bent Honoré, Gabriel A Rabinovich, Carsten S Larsen, Francesco d'Amore
No abstract text is available yet for this article.
October 23, 2017: AIDS
https://www.readbyqxmd.com/read/28990909/let-s-eliminate-diseases-not-institutes-the-case-for-the-fogarty-international-center
#18
Philip J Rosenthal, Karen A Goraleski, N Regina Rabinovich, Patricia F Walker
No abstract text is available yet for this article.
September 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28962837/can-triatoma-virus-inhibit-infection-of-trypanosoma-cruzi-chagas-1909-in-triatoma-infestans-klug-a-cross-infection-and-co-infection-study
#19
Gerardo Aníbal Marti, Paula Ragone, Agustín Balsalobre, Soledad Ceccarelli, María Laura Susevich, Patricio Diosque, María Gabriela Echeverría, Jorge Eduardo Rabinovich
Triatoma virus occurs infecting Triatominae in the wild (Argentina) and in insectaries (Brazil). Pathogenicity of Triatoma virus has been demonstrated in laboratory; accidental infections in insectaries produce high insect mortality. When more than one microorganism enters the same host, the biological interaction among them differs greatly depending on the nature and the infection order of the co-existing species of microorganisms. We studied the possible interactions between Triatoma virus (TrV) and Trypanosoma cruzi (the etiological agent of Chagas disease) in three different situations: (i) when Triatoma virus is inoculated into an insect host (Triatoma infestans) previously infected with T...
September 27, 2017: Journal of Invertebrate Pathology
https://www.readbyqxmd.com/read/28948482/effect-of-food-on-the-pharmacokinetics-of-single-and-multiple-dose-hydrocodone-extended-release-in-healthy-subjects
#20
Mary Bond, Laura Rabinovich-Guilatt, Sally Selim, Mona Darwish, William Tracewell, Philmore Robertson, Ronghua Yang, Richard Malamut, Philippe Colucci, Murray P Ducharme, Ofer Spiegelstein
BACKGROUND AND OBJECTIVES: Food intake can alter the pharmacokinetics of certain medications, including changes in their oral bioavailability, which is of particular concern for extended-release (ER) opioids because of the high drug loads. Two randomized, open-label studies assessed the effect of food on the pharmacokinetics of single and multiple doses of hydrocodone ER formulated with CIMA(®) Abuse-Deterrence Technology. METHODS: Healthy subjects in fed and fasted states received single 90-mg doses of hydrocodone ER (Studies 1 and 2) or multiple doses of hydrocodone ER (45 mg twice daily on days 2-3, 60 mg twice daily on days 4-5, 90 mg twice daily on days 6-10, and 90 mg once in the morning on day 11) (Study 2)...
December 2017: Clinical Drug Investigation
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