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https://www.readbyqxmd.com/read/29766399/consensus-guidelines-for-the-use-and-interpretation-of-angiogenesis-assays
#1
REVIEW
Patrycja Nowak-Sliwinska, Kari Alitalo, Elizabeth Allen, Andrey Anisimov, Alfred C Aplin, Robert Auerbach, Hellmut G Augustin, David O Bates, Judy R van Beijnum, R Hugh F Bender, Gabriele Bergers, Andreas Bikfalvi, Joyce Bischoff, Barbara C Böck, Peter C Brooks, Federico Bussolino, Bertan Cakir, Peter Carmeliet, Daniel Castranova, Anca M Cimpean, Ondine Cleaver, George Coukos, George E Davis, Michele De Palma, Anna Dimberg, Ruud P M Dings, Valentin Djonov, Andrew C Dudley, Neil P Dufton, Sarah-Maria Fendt, Napoleone Ferrara, Marcus Fruttiger, Dai Fukumura, Bart Ghesquière, Yan Gong, Robert J Griffin, Adrian L Harris, Christopher C W Hughes, Nan W Hultgren, M Luisa Iruela-Arispe, Melita Irving, Rakesh K Jain, Raghu Kalluri, Joanna Kalucka, Robert S Kerbel, Jan Kitajewski, Ingeborg Klaassen, Hynda K Kleinmann, Pieter Koolwijk, Elisabeth Kuczynski, Brenda R Kwak, Koen Marien, Juan M Melero-Martin, Lance L Munn, Roberto F Nicosia, Agnes Noel, Jussi Nurro, Anna-Karin Olsson, Tatiana V Petrova, Kristian Pietras, Roberto Pili, Jeffrey W Pollard, Mark J Post, Paul H A Quax, Gabriel A Rabinovich, Marius Raica, Anna M Randi, Domenico Ribatti, Curzio Ruegg, Reinier O Schlingemann, Stefan Schulte-Merker, Lois E H Smith, Jonathan W Song, Steven A Stacker, Jimmy Stalin, Amber N Stratman, Maureen Van de Velde, Victor W M van Hinsbergh, Peter B Vermeulen, Johannes Waltenberger, Brant M Weinstein, Hong Xin, Bahar Yetkin-Arik, Seppo Yla-Herttuala, Mervin C Yoder, Arjan W Griffioen
The formation of new blood vessels, or angiogenesis, is a complex process that plays important roles in growth and development, tissue and organ regeneration, as well as numerous pathological conditions. Angiogenesis undergoes multiple discrete steps that can be individually evaluated and quantified by a large number of bioassays. These independent assessments hold advantages but also have limitations. This article describes in vivo, ex vivo, and in vitro bioassays that are available for the evaluation of angiogenesis and highlights critical aspects that are relevant for their execution and proper interpretation...
May 15, 2018: Angiogenesis
https://www.readbyqxmd.com/read/29748363/historic-odyssey-the-institute-of-cardiovascular-sciences-past-present-and-future
#2
Illana Minuk, Inna Rabinovich-Nikitin, Lorrie A Kirshenbaum
No abstract text is available yet for this article.
May 11, 2018: Circulation Research
https://www.readbyqxmd.com/read/29723688/braf-mutant-lung-cancer-pd-l1-expression-tumor-mutational-burden-microsatellite-instability-status-and-response-to-immune-check-point-inhibitors
#3
Elizabeth Dudnik, Nir Peled, Hovav Nechushtan, Mira Wollner, Amir Onn, Abed Agbarya, Mor Moskovitz, Shoshana Keren, Noa Popovits-Hadari, Damien Urban, Moshe Mishaeli, Alona Zer, Aaron M Allen, Natalie Maimon Rabinovich, Ofer Rotem, Teodor Kuznetsov, Tzippy Shochat, Laila C Roisman, Jair Bar
INTRODUCTION: The efficacy of immune check-point inhibitors (ICPi) in BRAF mutant NSCLC is unknown. METHODS: Multi-institutional retrospective chart review identified 39 patients with BRAF mutant NSCLC. The patients were divided into two groups: V600E (Group A, n=21) and non-V600E (Group B, n=18). PD-L1 expression, tumor mutational burden (TMB) and microsatellite instability status (MSI) were assessed in 29 (74%), 11 (28%) and 12 (31%) patients, respectively. ORR, PFS with ICPi and OS were analyzed...
April 30, 2018: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/29723441/pharmacokinetic-and-pharmacodynamic-correlations-from-2-studies-evaluating-abuse-potential-of-hydrocodone-extended-release-tablets
#4
Kerri A Schoedel, Michael Gillespie, Naama Levy-Cooperman, Megan J Shram, Laura Rabinovich-Guilatt
Pharmacokinetic (PK)/pharmacodynamic (PD) correlations were explored in 2 human abuse potential studies of orally and intranasally administered hydrocodone extended-release (ER) 45 mg in healthy, nondependent opioid users. In a crossover study design, subjects received intact hydrocodone ER, finely milled hydrocodone ER, and hydrocodone powder in solution in the oral study and finely milled hydrocodone ER, hydrocodone powder, and finely milled Zohydro® ER in the intranasal study. Spearman ρ2 and Pearson r2 values were calculated for PD (maximum effect [Emax ] for "at the moment" Drug Liking, Overall Drug Liking, and Take Drug Again visual analog scales [VAS]) vs PK (partial area under the concentration-time curve [AUC], maximum drug concentration [Cmax ], time to Cmax [Tmax ], and abuse quotient [PK AQ; Cmax /Tmax ]) for all treatments...
May 3, 2018: Clinical Pharmacology in Drug Development
https://www.readbyqxmd.com/read/29716056/free-space-quantum-key-distribution-using-modulating-retro-reflectors
#5
William S Rabinovich, Rita Mahon, Mike S Ferraro, Peter G Goetz, Mark Bashkansky, Rachel E Freeman, John Reintjes, James L Murphy
Quantum key distribution (QKD) can be used to produce a cryptographic key whose security is guaranteed by quantum mechanics. The range of fiber-based QKD links is limited, by loss, to a few hundred kilometers, and cannot be used between mobile platforms. Free space QKD can, in principle, overcome these limitations. In practice, very narrow beam divergences must be used, requiring highly accurate pointing of the transmitting terminal to the receiver. This makes deployment very difficult. Here we describe the experimental implementation of a new type of free space QKD link, using modulating retro-reflectors (MRR)...
April 30, 2018: Optics Express
https://www.readbyqxmd.com/read/29712867/symbolic-emblems-of-the-levantine-aurignacians-as-a-regional-entity-identifier-hayonim-cave-lower-galilee-israel
#6
José-Miguel Tejero, Anna Belfer-Cohen, Ofer Bar-Yosef, Vitaly Gutkin, Rivka Rabinovich
The Levantine Aurignacian is a unique phenomenon in the local Upper Paleolithic sequence, showing greater similarity to the West European classic Aurignacian than to the local Levantine archaeological entities preceding and following it. Herewith we highlight another unique characteristic of this entity, namely, the presence of symbolic objects in the form of notched bones (mostly gazelle scapulae) from the Aurignacian levels of Hayonim Cave, Lower Galilee, Israel. Through both macroscopic and microscopic analyses of the items, we suggest that they are not mere cut marks but rather are intentional (decorative?) human-made markings...
April 30, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29688221/datatri-a-database-of-american-triatomine-species-occurrence
#7
Soledad Ceccarelli, Agustín Balsalobre, Paula Medone, María Eugenia Cano, Rodrigo Gurgel Gonçalves, Dora Feliciangeli, Darío Vezzani, Cristina Wisnivesky-Colli, David E Gorla, Gerardo A Marti, Jorge E Rabinovich
Trypanosoma cruzi, the causative agent of Chagas disease, is transmitted to mammals - including humans - by insect vectors of the subfamily Triatominae. We present the results of a compilation of triatomine occurrence and complementary ecological data that represents the most complete, integrated and updated database (DataTri) available on triatomine species at a continental scale. This database was assembled by collecting the records of triatomine species published from 1904 to 2017, spanning all American countries with triatomine presence...
April 24, 2018: Scientific Data
https://www.readbyqxmd.com/read/29659463/maintaining-short-peripheral-catheter-patency-a-comparison-of-saline-lock-versus-continuous-infusion-in-the-acute-care-setting
#8
Sheila Serr Roszell, Holly Barlowe Rabinovich, Cheryl A Smith-Miller
Sparse evidence exists about how short peripheral catheter (SPC) duration is affected by the presence of a saline lock versus continually infusing fluids. Often the choice to lock an SPC with saline is based on provider preference, rather than available evidence or patient-centered factors. This study compared the duration of 85 SPCs: locked with saline versus continuously running fluids. A secondary analysis considered the influence of a number of intermittent medications and flushes. Although the saline-locked group had a slightly longer duration time, it was not statistically significant...
May 2018: Journal of Infusion Nursing: the Official Publication of the Infusion Nurses Society
https://www.readbyqxmd.com/read/29648694/safety-of-nifedipine-in-threatened-preterm-labor-investigation-by-three-dimensional-echocardiography
#9
Leonti Grin, Avishag Laish-Farkash, Simon Shenhav, Xavier Piltz, Liah Ganelin, Mark Rabinovich, Eyal Y Anteby, Chaim Yosefy
OBJECTIVE: To evaluate atrial and ventricular parameters using real time three-dimensional transthoracic echocardiography (RT3DTTE) in women treated with nifedipine in the early third trimester (III-T) of pregnancy. METHODS: A prospective single-subject design study in a university-affiliated hospital, where each participant served as her own control. We studied 25 pregnant women at a gestational age of 25-33 weeks with TPTL prior to vs 48 hours postnifedipine treatment...
April 12, 2018: Echocardiography
https://www.readbyqxmd.com/read/29618419/proximal-row-carpectomy-using-decellularized-dermal-allograft
#10
REVIEW
Remy V Rabinovich, Steven J Lee
Wrist arthritis is a common problem. When managed early, motion-sparing procedures can be performed with successful outcomes. Proximal row carpectomy (PRC) has demonstrated good functional results and high patient satisfaction with up to 20-year follow-up. The majority of patients with longer follow-up have, however, exhibited radiographic signs of progressive degeneration of the radiocapitate space. Although radiographic changes have not been shown to correlate with wrist pain and function, it remains a concern and questions the durability of the radiocapitate articulation with continued patient follow-up, especially those who underwent the original procedure at a younger age...
April 2018: Journal of Hand Surgery
https://www.readbyqxmd.com/read/29615514/targeting-galectin-1-inhibits-pancreatic-cancer-progression-by-modulating-tumor-stroma-crosstalk
#11
Carlos A Orozco, Neus Martinez-Bosch, Pedro E Guerrero, Judith Vinaixa, Tomás Dalotto-Moreno, Mar Iglesias, Mireia Moreno, Magdolna Djurec, Françoise Poirier, Hans-Joachim Gabius, Martin E Fernandez-Zapico, Rosa F Hwang, Carmen Guerra, Gabriel A Rabinovich, Pilar Navarro
Pancreatic ductal adenocarcinoma (PDA) remains one of the most lethal tumor types, with extremely low survival rates due to late diagnosis and resistance to standard therapies. A more comprehensive understanding of the complexity of PDA pathobiology, and especially of the role of the tumor microenvironment in disease progression, should pave the way for therapies to improve patient response rates. In this study, we identify galectin-1 (Gal1), a glycan-binding protein that is highly overexpressed in PDA stroma, as a major driver of pancreatic cancer progression...
April 3, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29602753/ivermectin-repurposing-an-old-drug-to-complement-malaria-vector-control
#12
N Regina Rabinovich
No abstract text is available yet for this article.
March 27, 2018: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/29602445/galectins-multitask-signaling-molecules-linking-fibroblast-endothelial-and-immune-cell-programs-in-the-tumor-microenvironment
#13
María T Elola, Fátima Ferragut, Santiago P Méndez-Huergo, Diego O Croci, Candelaria Bracalente, Gabriel A Rabinovich
Tumor cells corrupt surrounding normal cells instructing them to support proliferative, pro-angiogenic and immunosuppressive networks that favor tumorigenesis and metastasis. This dynamic cross-talk is sustained by a range of intracellular signals and extracellular mediators produced by both tumoral and non-tumoral cells. Galectins -whether secreted or intracellularly expressed- play central roles in the tumorigenic process by delivering regulatory signals that contribute to reprogram fibroblasts, endothelial and immune cell programs...
March 21, 2018: Cellular Immunology
https://www.readbyqxmd.com/read/29555188/untangling-galectin-driven-regulatory-circuits-in-autoimmune-inflammation
#14
REVIEW
Marta A Toscano, Verónica C Martínez Allo, Anabela M Cutine, Gabriel A Rabinovich, Karina V Mariño
Although progress has been made in understanding the mechanisms implicated in the pathogenesis of autoimmune inflammation, studies aimed at identifying the mediators of these pathways will be necessary to develop more selective therapies. Galectins, a family of glycan-binding proteins, play central roles in immune cell homeostasis. Whereas some members of this family trigger regulatory programs that promote resolution of inflammation, others contribute to perpetuate autoimmune processes. We discuss the roles of endogenous galectins and their specific glycosylated ligands in shaping autoimmune responses by fueling, extinguishing, or rewiring immune circuits...
April 2018: Trends in Molecular Medicine
https://www.readbyqxmd.com/read/29546346/dynamics-of-afebrile-plasmodium-falciparum-infections-in-mozambican-men
#15
Beatriz Galatas, Helena Martí-Soler, Lidia Nhamussua, Pau Cisteró, Pedro Aide, Francisco Saute, Clara Menéndez, N Regina Rabinovich, Pedro L Alonso, Quique Bassat, Alfredo Mayor
Background: Afebrile Plasmodium falciparum infections usually remain undetected and untreated in the community and could potentially contribute to sustaining local malaria transmission in areas aiming for malaria elimination. Methods: Thirty-two men with afebrile P. falciparum infections detected with rapid diagnostic test (RDTs) were followed for 28 days. Kaplan-Meier estimates were computed to estimate probability of parasite positivity and of reducing parasitaemia by half of its initial level by day 28...
March 13, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29545799/galectins-in-intestinal-inflammation-galectin-1-expression-delineates-response-to-treatment-in-celiac-disease-patients
#16
Victoria Sundblad, Amado A Quintar, Luciano G Morosi, Sonia I Niveloni, Ana Cabanne, Edgardo Smecuol, Eduardo Mauriño, Karina V Mariño, Julio C Bai, Cristina A Maldonado, Gabriel A Rabinovich
Galectins, a family of animal lectins characterized by their affinity for N-acetyllactosamine-enriched glycoconjugates, modulate several immune cell processes shaping the course of innate and adaptive immune responses. Through interaction with a wide range of glycosylated receptors bearing complex branched N-glycans and core 2-O-glycans, these endogenous lectins trigger distinct signaling programs thereby controling immune cell activation, differentiation, recruitment and survival. Given the unique features of mucosal inflammation and the differential expression of galectins throughout the gastrointestinal tract, we discuss here key findings on the role of galectins in intestinal inflammation, particularly Crohn's disease, ulcerative colitis, and celiac disease (CeD) patients, as well as in murine models resembling these inflammatory conditions...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29545327/how-i-treat-the-post-thrombotic-syndrome
#17
Anat Rabinovich, Susan R Kahn
The post-thrombotic syndrome (PTS) is a chronic complication of deep vein thrombosis (DVT) that imposes significant morbidity, reduces quality of life and is costly. After DVT, 20-50% of patients will develop PTS, and up to 5% will develop severe PTS. The principal risk factors for PTS are anatomically extensive DVT, recurrent ipsilateral DVT, obesity and older age. By preventing the initial DVT and DVT recurrence, primary and secondary prophylaxis of DVT will reduce the occurrence of PTS. The effectiveness of elastic compression stockings (ECS) for PTS prevention is controversial...
March 15, 2018: Blood
https://www.readbyqxmd.com/read/29503063/physical-activity-in-copd-significance-prognosis-measurement-and-therapeutic-interventions
#18
Roberto A Rabinovich
No abstract text is available yet for this article.
March 1, 2018: Archivos de Bronconeumología
https://www.readbyqxmd.com/read/29495620/tribological-and-wear-performance-of-nanocomposite-pvd-hard-coatings-deposited-on-aluminum-die-casting-tool
#19
Jose Mario Paiva, German Fox-Rabinovich, Edinei Locks Junior, Pietro Stolf, Yassmin Seid Ahmed, Marcelo Matos Martins, Carlos Bork, Stephen Veldhuis
In the aluminum die casting process, erosion, corrosion, soldering, and die sticking have a significant influence on tool life and product quality. A number of coatings such as TiN, CrN, and (Cr,Al)N deposited by physical vapor deposition (PVD) have been employed to act as protective coatings due to their high hardness and chemical stability. In this study, the wear performance of two nanocomposite AlTiN and AlCrN coatings with different structures were evaluated. These coatings were deposited on aluminum die casting mold tool substrates (AISI H13 hot work steel) by PVD using pulsed cathodic arc evaporation, equipped with three lateral arc-rotating cathodes (LARC) and one central rotating cathode (CERC)...
February 28, 2018: Materials
https://www.readbyqxmd.com/read/29467674/an-improved-dynamic-model-for-the-respiratory-response-to-exercise
#20
Leidy Y Serna, Miguel A Mañanas, Alher M Hernández, Roberto A Rabinovich
Respiratory system modeling has been extensively studied in steady-state conditions to simulate sleep disorders, to predict its behavior under ventilatory diseases or stimuli and to simulate its interaction with mechanical ventilation. Nevertheless, the studies focused on the instantaneous response are limited, which restricts its application in clinical practice. The aim of this study is double: firstly, to analyze both dynamic and static responses of two known respiratory models under exercise stimuli by using an incremental exercise stimulus sequence (to analyze the model responses when step inputs are applied) and experimental data (to assess prediction capability of each model)...
2018: Frontiers in Physiology
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