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https://www.readbyqxmd.com/read/28205038/clinical-trial-simulations-and-pharmacometric-analysis-in-pediatrics-application-to-inhaled-loxapine-in-children-and-adolescents
#1
Min Dong, Tsuyoshi Fukuda, Sally Selim, Mark A Smith, Laura Rabinovich-Guilatt, James V Cassella, Alexander A Vinks
BACKGROUND AND OBJECTIVES: Loxapine for inhalation is a drug-device combination product approved in adults for the acute treatment of agitation associated with schizophrenia or bipolar I disorder. The primary objective of this study was to develop a clinical trial protocol to support a phase I pharmacokinetic study in children aged 10 years and older. In addition, this report details the results of the clinical study in relation to the predicted likelihood of achieving the target exposure associated with therapeutic effect in adults...
February 15, 2017: Clinical Pharmacokinetics
https://www.readbyqxmd.com/read/28166724/association-between-il-17-and-iga-in-the-joints-of-patients-with-inflammatory-arthropathies
#2
Ricardo Javier Eliçabe, Juan Eduardo Silva, Mabel Noemí Dave, María Gabriela Lacoste, Héctor Tamashiro, Rodrigo Blas, Alicia Munarriz, Gabriel Adrián Rabinovich, María Silvia Di Genaro
BACKGROUND: Hyperactive secretion and pathogenic effects of interleukin (IL)-17 and IgA have been detected in different arthropathies. Recent evidence has revealed that TH17 cytokines regulate mucosal IgA secretion. However, it is unknown whether and how IL-17 mediates synovial IgA production. Here we aim to investigate the connection of synovial IL-17 with IgA production in the joint. In this study we included synovial fluids (SF) from patients with rheumatoid arthritis (RA; n = 66), spondyloarthritis (SpA; n = 18) and osteoarthritis (OA; n = 36)...
February 6, 2017: BMC Immunology
https://www.readbyqxmd.com/read/28150971/effects-of-bupropion-sustained-release-on-task-related-eeg-alpha-activity-in-smokers-individual-differences-in-drug-response
#3
Jian Zhu, Ryan P Coppens, Norka E Rabinovich, David G Gilbert
The mechanisms underlying bupropion's efficacy as an antidepressant and a smoking cessation aid are far from being fully characterized. The present study is the first to examine the effects of bupropion on visuospatial task-related parietal EEG alpha power asymmetry-an asymmetry that has previously been found to be associated with severity of depressive symptoms (i.e., the more depressive symptoms, the greater alpha power in the right vs. left parietal area [Henriques & Davidson, 1997; Rabe, Debener, Brocke, & Beauducel, 2005])...
February 2017: Experimental and Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28137918/physical-activity-is-increased-by-a-12-week-semiautomated-telecoaching-programme-in-patients-with-copd-a-multicentre-randomised-controlled-trial
#4
H Demeyer, Z Louvaris, A Frei, R A Rabinovich, C de Jong, E Gimeno-Santos, M Loeckx, S C Buttery, N Rubio, T Van der Molen, N S Hopkinson, I Vogiatzis, M A Puhan, J Garcia-Aymerich, M I Polkey, T Troosters
RATIONALE: Reduced physical activity (PA) in patients with COPD is associated with a poor prognosis. Increasing PA is a key therapeutic target, but thus far few strategies have been found effective in this patient group. OBJECTIVES: To investigate the effectiveness of a 12-week semiautomated telecoaching intervention on PA in patients with COPD in a multicentre European randomised controlled trial. METHODS: 343 patients from six centres, encompassing a wide spectrum of disease severity, were randomly allocated to either a usual care group (UCG) or a telecoaching intervention group (IG) between June and December 2014...
January 30, 2017: Thorax
https://www.readbyqxmd.com/read/28112255/corrigendum-temporary-tattoo-for-long-term-high-fidelity-biopotential-recordings
#5
Lilach Bareket, Lilah Inzelberg, David Rand, Moshe David-Pur, David Rabinovich, Barak Brandes, Yael Hanein
No abstract text is available yet for this article.
January 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28088061/galectins-emerging-regulatory-checkpoints-linking-tumor-immunity-and-angiogenesis
#6
REVIEW
Santiago P Méndez-Huergo, Ada G Blidner, Gabriel A Rabinovich
Immune checkpoints, a plethora of inhibitory pathways aimed at maintaining immune cell homeostasis, may be co-opted by cancer cells to evade immune destruction. Therapies targeting immune checkpoints have reached a momentum yielding significant clinical benefits in patients with various malignancies by unleashing anti-tumor immunity. Galectins, a family of glycan-binding proteins, have emerged as novel regulatory checkpoints that promote immune evasive programs by inducing T-cell exhaustion, limiting T-cell survival, favoring expansion of regulatory T cells, de-activating natural killer cells and polarizing myeloid cells toward an immunosuppressive phenotype...
January 11, 2017: Current Opinion in Immunology
https://www.readbyqxmd.com/read/28079156/a-mucin-like-peptide-from-fasciola-hepatica-instructs-dendritic-cells-with-parasite-specific-th1-polarizing-activity
#7
Verónica Noya, Natalie Brossard, Ernesto Rodríguez, L Sebastián Dergan-Dylon, Carlos Carmona, Gabriel A Rabinovich, Teresa Freire
Fasciolosis is a trematode zoonosis of interest in public health and cattle production. We report here the immunostimulatory effect of a 66 mer mucin-like peptide from Fasciola hepatica (Fhmuc), which synergizes with lipopolysaccharide (LPS) to promote dendritic cell (DC) maturation, endowing these cells with Th1-polarizing capacity. Exposure of DCs to Fhmuc in presence of LPS induced enhanced secretion of pro-inflammatory cytokines and expression of co-stimulatory molecules by DCs, promoting their T cell stimulatory capacity and selectively augmenting IFN-γ secretion by allogeneic T cells...
January 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28077738/evidence-based-policies-on-migration-and-global-health-are-essential-to-maintain-the-health-of-those-inside-and-outside-the-united-states
#8
EDITORIAL
Philip J Rosenthal, Daniel G Bausch, Stephen Higgs, N Regina Rabinovich, David R Hill, Christopher V Plowe, Karen A Goraleski, Patricia F Walker
No abstract text is available yet for this article.
January 11, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28065670/oral-slow-release-ivermectin-biting-back-at-malaria-vectors
#9
Carlos J Chaccour, N Regina Rabinovich
Bellinger and colleagues offer an elegant twist for a promising new tool against malaria. This formulation is designed to release ivermectin, a mosquito-killing drug for 10 days after a single oral dose. This could reduce the vector population and serve as a complementary tool for malaria elimination.
January 5, 2017: Trends in Parasitology
https://www.readbyqxmd.com/read/28039138/an-effective-counterselection-system-for-listeria-monocytogenes-and-its-use-to-characterize-10403s-strain-monocin-genomic-region
#10
Tal Argov, Lev Rabinovich, Nadejda Sigal, Anat A Herskovits
Construction of Listeria monocytogenes mutants by allelic exchange has been laborious and time consuming due to lack of proficient selection markers for the final recombination event. That is, a marker conveying substance sensitivity to the bacteria bearing it, enabling the exclusion of merodiploids and selection for plasmid loss. In order to address this issue, we engineered a counterselection marker based on a mutated phenylalanyl-tRNA synthetase gene (pheS*). This mutation renders the phenylalanine-binding site of the enzyme more promiscuous and allows the binding of the toxic p-chloro-phenylalanine analog (p-Cl-phe) as a substrate...
December 30, 2016: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28038409/development-of-betavoltaic-cell-technology-production-based-on-microchannel-silicon-and-its-electrical-parameters-evaluation
#11
A A Krasnov, V V Starkov, S A Legotin, O I Rabinovich, S I Didenko, V N Murashev, V V Cheverikin, E B Yakimov, N A Fedulova, B I Rogozev, A S Laryushkin
In the paper a manufacturing process of three-dimensional (3D) microchannel structure by silicon (Si) anodic etching was discussed. The possibility of microchannels formation allows to increase the active area more than 100 times. In this structure the p-n junction on the whole Si surface was formed. The obtained data allowed to evaluate the characteristics of the betavoltaic converter with a 3D structure by using isotope 63Ni with a specific activity of 10Ci/g.
March 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/28028602/negative-affect-subtypes-and-craving-differentially-predict-long-term-cessation-success-among-smokers-achieving-initial-abstinence
#12
Yantao Zuo, Norka E Rabinovich, David G Gilbert
OBJECTIVE: This study aimed to examine the associations of individual trajectories of three types of negative affect (NA: anxiety, depression, and anger) and craving during a 44-day period of incentivized smoking abstinence period with cessation outcome at 3 months and at 1 year. METHODS: Adult smokers (N = 140) completed questionnaire assessments of NA and craving during pre-quit baseline sessions and 15 postquit sessions over the 45 days of biochemically verified abstinence while on nicotine or placebo patch treatment...
March 2017: Psychopharmacology
https://www.readbyqxmd.com/read/27986367/translating-the-sugar-code-into-immune-and-vascular-signaling-programs
#13
REVIEW
Juan P Cerliani, Ada G Blidner, Marta A Toscano, Diego O Croci, Gabriel A Rabinovich
The vast range and complexity of glycan structures and their dynamic variations in health and disease have presented formidable challenges toward understanding the biological significance of these molecules. Despite these limitations, compelling evidence highlights a major role for galectins, a family of soluble glycan-binding proteins, as endogenous decoders that translate glycan-containing information into a broad spectrum of cellular responses by modulating receptor clustering, reorganization, endocytosis, and signaling...
December 13, 2016: Trends in Biochemical Sciences
https://www.readbyqxmd.com/read/27984078/anti-inflammatory-and-protective-effects-of-mt-031-a-novel-multitarget-mao-a-and-ache-buche-inhibitor-in-scopolamine-mouse-model-and-inflammatory-cells
#14
Wei Liu, Alon Rabinovich, Yuval Nash, Dan Frenkel, Yuqiang Wang, Moussa B H Youdim, Orly Weinreb
Previous study demonstrated that the novel multitarget compound, MT-031 preserved in one molecule entity the beneficial properties of its parent drugs, rasagiline and rivastigmine, and exerted high dual potencies of monoamine oxidase-A (MAO-A) and cholinesterase (ChE) inhibition in acute-treated mice and neuroprotective effects against H2O2-induced neurotoxicity in human neuroblastoma SH-SY5Y cells. The present study aimed to further investigate the anti-inflammatory and protective effects of MT-031 in scopolamine mouse model and inflammatory cell cultures...
October 28, 2016: Neuropharmacology
https://www.readbyqxmd.com/read/27973556/application-of-mixed-effects-limits-of-agreement-in-the-presence-of-multiple-sources-of-variability-exemplar-from-the-comparison-of-several-devices-to-measure-respiratory-rate-in-copd-patients
#15
Richard A Parker, Christopher J Weir, Noah Rubio, Roberto Rabinovich, Hilary Pinnock, Janet Hanley, Lucy McCloughan, Ellen M Drost, Leandro C Mantoani, William MacNee, Brian McKinstry
INTRODUCTION: The Bland-Altman limits of agreement method is widely used to assess how well the measurements produced by two raters, devices or systems agree with each other. However, mixed effects versions of the method which take into account multiple sources of variability are less well described in the literature. We address the practical challenges of applying mixed effects limits of agreement to the comparison of several devices to measure respiratory rate in patients with chronic obstructive pulmonary disease (COPD)...
2016: PloS One
https://www.readbyqxmd.com/read/27890784/identifying-residues-that-determine-scf-molecular-level-interactions-through-a-combination-of-experimental-and-in-silico-analyses
#16
Eitan Rabinovich, Michael Heyne, Anna Bakhman, Mickey Kosloff, Julia M Shifman, Niv Papo
The stem cell factor (SCF)/c-Kit receptor tyrosine kinase complex-with its significant roles in hematopoiesis and angiogenesis-is an attractive target for rational drug design. There is thus a need to map, in detail, the SCF/c-Kit interaction sites and the mechanisms that modulate this interaction. While most residues in the direct SCF/c-Kit binding interface can be identified from the existing crystal structure of the complex, other residues that affect binding through protein unfolding, intermolecular interactions, allosteric or long-distance electrostatic effects cannot be directly inferred...
January 6, 2017: Journal of Molecular Biology
https://www.readbyqxmd.com/read/27883066/meteotsunamis-in-the-laurentian-great-lakes
#17
Adam J Bechle, Chin H Wu, David A R Kristovich, Eric J Anderson, David J Schwab, Alexander B Rabinovich
The generation mechanism of meteotsunamis, which are meteorologically induced water waves with spatial/temporal characteristics and behavior similar to seismic tsunamis, is poorly understood. We quantify meteotsunamis in terms of seasonality, causes, and occurrence frequency through the analysis of long-term water level records in the Laurentian Great Lakes. The majority of the observed meteotsunamis happen from late-spring to mid-summer and are associated primarily with convective storms. Meteotsunami events of potentially dangerous magnitude (height > 0...
November 24, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27860129/the-postthrombotic-syndrome-current-evidence-and-future-challenges
#18
REVIEW
A Rabinovich, S R Kahn
Postthrombotic syndrome (PTS) is a chronic complication of deep vein thrombosis (DVT) that develops in 20-50% of patients. PTS manifests as a spectrum of symptoms and signs of chronic venous insufficiency that can impose significant morbidity and have a negative impact on quality of life. Chronic venous hypertension caused by a combination of residual venous obstruction and valvular reflux is believed to play a major role in the pathophysiology of PTS. The Villalta scale is the most widely applied clinical scale used to diagnose and define PTS...
November 18, 2016: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/27851120/1484-evaluation-of-vasopressin-use-in-patients-with-septic-shock-at-a-large-academic-institution
#19
Nicholas Barker, Marina Rabinovich
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27850917/1281-evaluation-of-the-incidence-of-hypoglycemia-in-critically-ill-patients-receiving-insulin-therapy
#20
Marina Rabinovich, Jessica Grahl
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
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