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https://www.readbyqxmd.com/read/28405776/immune-mediated-and-hypoxia-regulated-programs-accomplices-in-resistance-to-anti-angiogenic-therapies
#1
Diego O Croci, Santiago P Mendez-Huergo, Juan P Cerliani, Gabriel A Rabinovich
In contrast to mechanisms taking place during resistance to chemotherapies or other targeted therapies, compensatory adaptation to angiogenesis blockade does not imply a mutational alteration of genes encoding drug targets or multidrug resistance mechanisms but instead involves intrinsic or acquired activation of compensatory angiogenic pathways. In this article we highlight hypoxia-regulated and immune-mediated mechanisms that converge in endothelial cell programs and preserve angiogenesis in settings of vascular endothelial growth factor (VEGF) blockade...
April 13, 2017: Handbook of Experimental Pharmacology
https://www.readbyqxmd.com/read/28396325/metabolic-genetic-screens-reveal-multidimensional-regulation-of-virulence-gene-expression-in-listeria-monocytogenes-and-an-aminopeptidase-that-is-critical-for-prfa-protein-activation
#2
Sivan Friedman, Marika Linsky, Lior Lobel, Lev Rabinovich, Nadejda Sigal, Anat A Herskovits
Listeria monocytogenes is an environmental saprophyte and intracellular bacterial pathogen. Upon invading mammalian cells, the bacterium senses abrupt changes in its metabolic environment, which are rapidly transduced to regulation of virulence gene expression. To explore the relationship between L. monocytogenes metabolism and virulence, we monitored virulence gene expression dynamics across a library of genetic mutants grown under two metabolic conditions known to activate the virulent state: charcoal-treated rich medium containing glucose 1-phosphate and minimal defined medium containing limiting concentrations of branched-chain amino acids (BCAAs)...
April 10, 2017: Infection and Immunity
https://www.readbyqxmd.com/read/28373557/quantitative-criticism-of-literary-relationships
#3
Joseph P Dexter, Theodore Katz, Nilesh Tripuraneni, Tathagata Dasgupta, Ajay Kannan, James A Brofos, Jorge A Bonilla Lopez, Lea A Schroeder, Adriana Casarez, Maxim Rabinovich, Ayelet Haimson Lushkov, Pramit Chaudhuri
Authors often convey meaning by referring to or imitating prior works of literature, a process that creates complex networks of literary relationships ("intertextuality") and contributes to cultural evolution. In this paper, we use techniques from stylometry and machine learning to address subjective literary critical questions about Latin literature, a corpus marked by an extraordinary concentration of intertextuality. Our work, which we term "quantitative criticism," focuses on case studies involving two influential Roman authors, the playwright Seneca and the historian Livy...
April 3, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28365145/the-double-thenar-flap-a-technique-to-reconstruct-2-fingertip-amputations-simultaneously
#4
REVIEW
Daniel B Polatsch, Remy V Rabinovich, Steven Beldner
Fingertip injuries are a common problem. There may be pulp loss and exposed bone. Various techniques have been described to reconstruct function as well as aesthetics; yet it is still unclear which treatment options should be chosen for each specific injury. Evidence-based treatment strategies are limited because there are no prospective randomized clinical trials evaluating one method with another. Fingertip injuries are usually variable in their presentation, and therefore treatment decisions are often dictated by the knowledge and expertise of the treating physician combined with the patient's unique injury...
March 29, 2017: Journal of Hand Surgery
https://www.readbyqxmd.com/read/28317823/-functional-cardiovascular-assessment-in-dentists-performing-local-anesthesia-in-out-patient-settings
#5
S A Rabinovich, S N Razumova, Yu L Vasil'ev
The article presents the results of the cardiovascular changes assessment using electrocardiography (ECG) monitoring during local anesthesia in GP dentists. Selective ECG monitoring was carried out in 60 dentists aged 25-55 years (1 group - 25-34 y.o.; 2 group - 35-44 y.o.; 3 group - 45-55 y.o.) by means of portable «Valens» system. The study of stress index or the index of regulatory systems tension (IT) was conducted for 6 hours in the first day half within 1 working day. IT from 50 to 150 relative units was considered normal...
2017: Stomatologii︠a︡
https://www.readbyqxmd.com/read/28294391/a-population-pharmacokinetic-meta-analysis-of-custirsen-an-antisense-oligonucleotide-in-oncology-patients-and-healthy-subjects
#6
Alena Y Edwards, Anna Elgart, Colm Farrell, Ofra Barnett-Griness, Laura Rabinovich-Guilatt, Ofer Spiegelstein
AIMS: Custirsen (OGX-011/TV-1011), a second-generation antisense oligonucleotide that reduces clusterin production, is under investigation with chemotherapy in prostate and lung cancer. This meta-analysis evaluated the population pharmacokinetics (PK) of custirsen in cancer patients and healthy subjects. METHODS: The population PK analysis used custirsen plasma concentrations from five phase 1 studies, one phase 1/2 study, and one phase 3 study in two stages. Cancer patients received multiple doses of custirsen (40-640 mg intravenously over 120 minutes) with chemotherapy; healthy subjects received single or multiple doses (320-640 mg)...
March 11, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28294120/down-regulation-of-adam33-as-a-predictive-biomarker-of-aggressive-breast-cancer
#7
Graciele C M Manica, Caroline F Ribeiro, Marco A S de Oliveira, Isabela T Pereira, Andressa Chequin, Edneia A S Ramos, Liliane M B Klassen, Ana Paula M Sebastião, Larissa M Alvarenga, Silvio M Zanata, Lucia De Noronha, Iris Rabinovich, Fabricio F Costa, Emanuel M Souza, Giseli Klassen
Breast cancer is a heterogeneous disease with differences in its clinical, molecular and biological features. Traditionally, immunohistochemical markers together with clinicopathologic parameters are used to classify breast cancer and to predict disease outcome. Triple-negative breast cancer (TNBC) is a particular type of breast cancer that is defined by a lack of expression of hormonal receptors and the HER2 gene. Most cases of TNBC also have a basal-like phenotype (BLBC) with expression of cytokeratin 5/6 and/or EGFR...
March 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28277909/late-preterm-and-early-term-when-to-induce-a-growth-restricted-fetus-a-population-based-study
#8
Alex Rabinovich, Tehila Tsemach, Lena Novack, Moshe Mazor, Tal Rafaeli-Yehudai, Orna Staretz-Chacham, Ruth Beer Weisel, Vered Klaitman-Mayer, Salvatore A Mastrolia, Offer Erez
PURPOSE: 1) Compare fetal and neonatal morbidity and mortality associated with induction of labor (IOL) vs. expectant management (EM) in women with isolated fetal growth restriction (FGR) between [Formula: see text] - [Formula: see text] weeks; 2) Determine optimal gestational age for delivery of such fetuses. MATERIALS AND METHODS: A retrospective population based cohort study of 2232 parturients with isolated FGR, including two groups: 1) IOL (n = 1428); 2) EM (n= 804)...
March 3, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28262745/a-biomimetic-gelatin-based-platform-elicits-a-pro-differentiation-effect-on-podocytes-through-mechanotransduction
#9
Mufeng Hu, Evren U Azeloglu, Amit Ron, Khanh-Hoa Tran-Ba, Rhodora C Calizo, Iman Tavassoly, Smiti Bhattacharya, Gomathi Jayaraman, Yibang Chen, Vera Rabinovich, Ravi Iyengar, James C Hone, John C He, Laura J Kaufman
Using a gelatin microbial transglutaminase (gelatin-mTG) cell culture platform tuned to exhibit stiffness spanning that of healthy and diseased glomeruli, we demonstrate that kidney podocytes show marked stiffness sensitivity. Podocyte-specific markers that are critical in the formation of the renal filtration barrier are found to be regulated in association with stiffness-mediated cellular behaviors. While podocytes typically de-differentiate in culture and show diminished physiological function in nephropathies characterized by altered tissue stiffness, we show that gelatin-mTG substrates with Young's modulus near that of healthy glomeruli elicit a pro-differentiation and maturation response in podocytes better than substrates either softer or stiffer...
March 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28205038/clinical-trial-simulations-and-pharmacometric-analysis-in-pediatrics-application-to-inhaled-loxapine-in-children-and-adolescents
#10
Min Dong, Tsuyoshi Fukuda, Sally Selim, Mark A Smith, Laura Rabinovich-Guilatt, James V Cassella, Alexander A Vinks
BACKGROUND AND OBJECTIVES: Loxapine for inhalation is a drug-device combination product approved in adults for the acute treatment of agitation associated with schizophrenia or bipolar I disorder. The primary objective of this study was to develop a clinical trial protocol to support a phase I pharmacokinetic study in children aged 10 years and older. In addition, this report details the results of the clinical study in relation to the predicted likelihood of achieving the target exposure associated with therapeutic effect in adults...
February 15, 2017: Clinical Pharmacokinetics
https://www.readbyqxmd.com/read/28166724/association-between-il-17-and-iga-in-the-joints-of-patients-with-inflammatory-arthropathies
#11
Ricardo Javier Eliçabe, Juan Eduardo Silva, Mabel Noemí Dave, María Gabriela Lacoste, Héctor Tamashiro, Rodrigo Blas, Alicia Munarriz, Gabriel Adrián Rabinovich, María Silvia Di Genaro
BACKGROUND: Hyperactive secretion and pathogenic effects of interleukin (IL)-17 and IgA have been detected in different arthropathies. Recent evidence has revealed that TH17 cytokines regulate mucosal IgA secretion. However, it is unknown whether and how IL-17 mediates synovial IgA production. Here we aim to investigate the connection of synovial IL-17 with IgA production in the joint. In this study we included synovial fluids (SF) from patients with rheumatoid arthritis (RA; n = 66), spondyloarthritis (SpA; n = 18) and osteoarthritis (OA; n = 36)...
February 6, 2017: BMC Immunology
https://www.readbyqxmd.com/read/28150971/effects-of-bupropion-sustained-release-on-task-related-eeg-alpha-activity-in-smokers-individual-differences-in-drug-response
#12
Jian Zhu, Ryan P Coppens, Norka E Rabinovich, David G Gilbert
The mechanisms underlying bupropion's efficacy as an antidepressant and a smoking cessation aid are far from being fully characterized. The present study is the first to examine the effects of bupropion on visuospatial task-related parietal EEG alpha power asymmetry-an asymmetry that has previously been found to be associated with severity of depressive symptoms (i.e., the more depressive symptoms, the greater alpha power in the right vs. left parietal area [Henriques & Davidson, 1997; Rabe, Debener, Brocke, & Beauducel, 2005])...
February 2017: Experimental and Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28137918/physical-activity-is-increased-by-a-12-week-semiautomated-telecoaching-programme-in-patients-with-copd-a-multicentre-randomised-controlled-trial
#13
H Demeyer, Z Louvaris, A Frei, R A Rabinovich, C de Jong, E Gimeno-Santos, M Loeckx, S C Buttery, N Rubio, T Van der Molen, N S Hopkinson, I Vogiatzis, M A Puhan, J Garcia-Aymerich, M I Polkey, T Troosters
RATIONALE: Reduced physical activity (PA) in patients with COPD is associated with a poor prognosis. Increasing PA is a key therapeutic target, but thus far few strategies have been found effective in this patient group. OBJECTIVES: To investigate the effectiveness of a 12-week semiautomated telecoaching intervention on PA in patients with COPD in a multicentre European randomised controlled trial. METHODS: 343 patients from six centres, encompassing a wide spectrum of disease severity, were randomly allocated to either a usual care group (UCG) or a telecoaching intervention group (IG) between June and December 2014...
January 30, 2017: Thorax
https://www.readbyqxmd.com/read/28112255/corrigendum-temporary-tattoo-for-long-term-high-fidelity-biopotential-recordings
#14
Lilach Bareket, Lilah Inzelberg, David Rand, Moshe David-Pur, David Rabinovich, Barak Brandes, Yael Hanein
No abstract text is available yet for this article.
January 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28088061/galectins-emerging-regulatory-checkpoints-linking-tumor-immunity-and-angiogenesis
#15
REVIEW
Santiago P Méndez-Huergo, Ada G Blidner, Gabriel A Rabinovich
Immune checkpoints, a plethora of inhibitory pathways aimed at maintaining immune cell homeostasis, may be co-opted by cancer cells to evade immune destruction. Therapies targeting immune checkpoints have reached a momentum yielding significant clinical benefits in patients with various malignancies by unleashing anti-tumor immunity. Galectins, a family of glycan-binding proteins, have emerged as novel regulatory checkpoints that promote immune evasive programs by inducing T-cell exhaustion, limiting T-cell survival, favoring expansion of regulatory T cells, de-activating natural killer cells and polarizing myeloid cells toward an immunosuppressive phenotype...
January 11, 2017: Current Opinion in Immunology
https://www.readbyqxmd.com/read/28079156/a-mucin-like-peptide-from-fasciola-hepatica-instructs-dendritic-cells-with-parasite-specific-th1-polarizing-activity
#16
Verónica Noya, Natalie Brossard, Ernesto Rodríguez, L Sebastián Dergan-Dylon, Carlos Carmona, Gabriel A Rabinovich, Teresa Freire
Fasciolosis is a trematode zoonosis of interest in public health and cattle production. We report here the immunostimulatory effect of a 66 mer mucin-like peptide from Fasciola hepatica (Fhmuc), which synergizes with lipopolysaccharide (LPS) to promote dendritic cell (DC) maturation, endowing these cells with Th1-polarizing capacity. Exposure of DCs to Fhmuc in presence of LPS induced enhanced secretion of pro-inflammatory cytokines and expression of co-stimulatory molecules by DCs, promoting their T cell stimulatory capacity and selectively augmenting IFN-γ secretion by allogeneic T cells...
January 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28077738/evidence-based-policies-on-migration-and-global-health-are-essential-to-maintain-the-health-of-those-inside-and-outside-the-united-states
#17
EDITORIAL
Philip J Rosenthal, Daniel G Bausch, Stephen Higgs, N Regina Rabinovich, David R Hill, Christopher V Plowe, Karen A Goraleski, Patricia F Walker
No abstract text is available yet for this article.
January 11, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28065670/oral-slow-release-ivermectin-biting-back-at-malaria-vectors
#18
Carlos J Chaccour, N Regina Rabinovich
Bellinger and colleagues offer an elegant twist for a promising new tool against malaria. This formulation is designed to release ivermectin, a mosquito-killing drug for 10 days after a single oral dose. This could reduce the vector population and serve as a complementary tool for malaria elimination.
March 2017: Trends in Parasitology
https://www.readbyqxmd.com/read/28039138/an-effective-counterselection-system-for-listeria-monocytogenes-and-its-use-to-characterize-the-monocin-genomic-region-of-strain-10403s
#19
Tal Argov, Lev Rabinovich, Nadejda Sigal, Anat A Herskovits
Construction of Listeria monocytogenes mutants by allelic exchange has been laborious and time-consuming due to lack of proficient selection markers for the final recombination event, that is, a marker conveying substance sensitivity to the bacteria bearing it, enabling the exclusion of merodiploids and selection for plasmid loss. In order to address this issue, we engineered a counterselection marker based on a mutated phenylalanyl-tRNA synthetase gene (pheS*). This mutation renders the phenylalanine-binding site of the enzyme more promiscuous and allows the binding of the toxic p-chloro-phenylalanine analog (p-Cl-phe) as a substrate...
March 15, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28038409/development-of-betavoltaic-cell-technology-production-based-on-microchannel-silicon-and-its-electrical-parameters-evaluation
#20
A A Krasnov, V V Starkov, S A Legotin, O I Rabinovich, S I Didenko, V N Murashev, V V Cheverikin, E B Yakimov, N A Fedulova, B I Rogozev, A S Laryushkin
In the paper a manufacturing process of three-dimensional (3D) microchannel structure by silicon (Si) anodic etching was discussed. The possibility of microchannels formation allows to increase the active area more than 100 times. In this structure the p-n junction on the whole Si surface was formed. The obtained data allowed to evaluate the characteristics of the betavoltaic converter with a 3D structure by using isotope 63Ni with a specific activity of 10Ci/g.
March 2017: Applied Radiation and Isotopes
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