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H C Hoyos, Mariel Marder, R Ulrich, V Gudi, M Stangel, G A Rabinovich, L A Pasquini, J M Pasquini
The aim of this work was to combine our previously published results with our new data to show how galectin-3 (Gal-3) controls myelin integrity and function, promotes oligodendroglial cell differentiation, and regulates microglial responses to limit cuprizone- (CPZ)-induced demyelination and foster remyelination. In this study, 8-week-old Gal-3-deficient (Lgals3 (-/-)) and wild type (WT) mice were fed a diet containing 0.2 % CPZ w/w for 6 weeks, after which CPZ was withdrawn in order to allow remyelination...
2016: Advances in Experimental Medicine and Biology
Stephen J Balevic, C Egla Rabinovich
Uveitis refers to the presence of intraocular inflammation, and as a strict definition compromises the iris and ciliary body anteriorly and the choroid posteriorly (the uvea). Untreated, uveitis can lead to visual loss or blindness. The etiology of uveitis can include both infectious and noninfectious (usually immune-mediated) causes, the latter of which are often mediated predominantly by Th1 CD4(+) T-cells that secrete proinflammatory cytokines. Tumor necrosis factor-alpha (TNF-α) is a proinflammatory cytokine involved in the pathogenesis of uveitis, which at high concentrations can cause excess inflammation and tissue damage...
2016: Drug Design, Development and Therapy
O F Rabinovich, I M Rabinovich, A V Guseva
The aim of the study was to elaborate the rationale for the application of photodynamic therapy in complex treatment of patient with severe oral lichen planus. Complex clinical and laboratory examination and treatment was performed in 54 patients divided on 3 groups. Diagnosis of oral lichen planus was based on clinical, histological and immunohistochemical features. Group 1 received standard treatment, in the second group photodynamic therapy was conducted in addition to conventional treatment, patients in the third group received only photodynamic therapy...
2016: Stomatologii︠a︡
Mariana Rinaldi, Laura Thomas, Patricia Mathieu, Pablo Carabias, Maria F Troncoso, Juana M Pasquini, Gabriel A Rabinovich, Laura A Pasquini
Galectin-1 (Gal-1), a member of a highly conserved family of animal lectins, binds to the common disaccharide [Galβ(1-4)-GlcNAc] on both N- and O-glycans decorating cell surface glycoconjugates. Current evidence supports a role for Gal-1 in the pathophysiology of multiple sclerosis (MS), one of the most prevalent chronic inflammatory diseases. Previous studies showed that Gal-1 exerts neuroprotective effects by promoting microglial deactivation in a model of autoimmune neuroinflammation and induces axonal regeneration in spinal cord injury...
September 6, 2016: Neurobiology of Disease
V P Baklaushev, N F Grinenko, G M Yusubalieva, I L Gubskii, M S Burenkov, E Z Rabinovich, N V Ivanova, V P Chekhonin
The efficiency of monotherapy with zoledronic acid (Resorba), doxorubicin, and their combination was studied on the model of metastasizing breast carcinoma in BALB/c mice. Doxorubicin monotherapy was accompanied by a significant increase in median survival up to 57 days (vs. 34 and 35 days in control groups); 27% animals survived for 90 days (duration of the study). Bioluminescence area of the primary tumor significantly decreased on days 21 and 28; the total number of visceral metastases also decreased according to magnetic-resonance imaging data...
August 2016: Bulletin of Experimental Biology and Medicine
Juan Carlos Higareda-Almaraz, Juan S Ruiz-Moreno, Jana Klimentova, Daniela Barbieri, Raquel Salvador-Gallego, Regina Ly, Ilse A Valtierra-Gutierrez, Christiane Dinsart, Gabriel A Rabinovich, Jiri Stulik, Frank Rösl, Bladimiro Rincon-Orozco
BACKGROUND: Galectin-7 (Gal-7) is negatively regulated in cervical cancer, and appears to be a link between the apoptotic response triggered by cancer and the anti-tumoral activity of the immune system. Our understanding of how cervical cancer cells and their molecular networks adapt in response to the expression of Gal-7 remains limited. METHODS: Meta-analysis of Gal-7 expression was conducted in three cervical cancer cohort studies and TCGA. In silico prediction and bisulfite sequencing were performed to inquire epigenetic alterations...
2016: BMC Cancer
Dannit Licht, Rachel Cohen, Ofer Spiegelstein, Laura Rabinovich-Guilatt, Marina Zholkovsky, Adrian Gilbert, Jennifer B Dressman, Muhammad Safadi
OBJECTIVES: While bioequivalence between enteric-coated and immediate-release formulations can be achieved in terms of AUC, gastric emptying of enteric-coated dosage forms is a stochastic event, usually leading to lower Cmax values than those observed with the corresponding immediate release. This article examines challenges of developing enteric-coated dosage forms which are bioequivalent to the corresponding immediate-release formulations in terms of both AUC and Cmax using rasagiline as a model compound...
October 2016: Journal of Pharmacy and Pharmacology
Jonathan J Hammersley, David G Gilbert, Adam Rzetelny, Norka E Rabinovich
INTRODUCTION AND RATIONALE: Given baseline-dependent effects of nicotine on other forms of attention, there is reason to believe that inconsistent findings for the effects of nicotine on attentional orienting may be partly due to individual differences in baseline (abstinence state) functioning. Individuals with low baseline attention may benefit more from nicotine replacement. METHOD: The effects of nicotine as a function of baseline performance (bottom, middle, and top third of mean reaction times during placebo) were assessed in 52 habitual abstinent smokers (26 females/26 males) utilizing an arrow-cued covert orienting of attention task...
October 2016: Pharmacology, Biochemistry, and Behavior
Xiao Na Ge, Sung Gil Ha, Yana G Greenberg, Amrita Rao, Idil Bastan, Ada G Blidner, Savita P Rao, Gabriel A Rabinovich, P Sriramarao
Galectin-1 (Gal-1), a glycan-binding protein with broad antiinflammatory activities, functions as a proresolving mediator in autoimmune and chronic inflammatory disorders. However, its role in allergic airway inflammation has not yet been elucidated. We evaluated the effects of Gal-1 on eosinophil function and its role in a mouse model of allergic asthma. Allergen exposure resulted in airway recruitment of Gal-1-expressing inflammatory cells, including eosinophils, as well as increased Gal-1 in extracellular spaces in the lungs...
August 16, 2016: Proceedings of the National Academy of Sciences of the United States of America
Salvatore Andrea Mastrolia, Lena Novack, Jecko Thachil, Anat Rabinovich, Oleg Pikovsky, Vered Klaitman, Giuseppe Loverro, Offer Erez
Placental mediated pregnancy complications such as preeclampsia and fetal growth restriction (FGR) are common, serious, and associated with increased morbidity and mortality. We conducted a systematic review and meta-analysis to determine the effect of treatment with low-molecular-weight heparins (LMWHs) for secondary prevention of these complications in non thrombophilic women. We searched the electronic databases PubMed, Scopus, and Cochrane Library for randomised controlled trials addressing this question...
July 21, 2016: Thrombosis and Haemostasis
Alexis M Kalergis, Marcus Lacerda, Gabriel A Rabinovich, Yvonne Rosenstein
Despite political turmoil and economical crisis, research in Latin America has considerably advanced over recent decades. The present 'Point of View' outlines our perspectives on the working conditions, successes, difficulties, limitations, and challenges of biomedical scientific communities in four Latin American countries: Argentina (G.A.R.), Brazil (M.L.), Chile (A.K.), and Mexico (Y.R.).
September 2016: Trends in Molecular Medicine
Marcel W Pruessner, Doweon Park, Todd H Stievater, Dmitry A Kozak, William S Rabinovich
Photonic integrated circuits have enabled progressively active functionality in compact devices with the potential for large-scale integration. To date the lowest loss photonic circuits are achieved with silica or silicon nitride-based platforms. However, these materials generally lack reconfigurability. In this work we present a platform for achieving active functionality in any dielectric waveguide via large-scale opto-electro-mechanical tuning of the effective refractive index (Δn<sub>eff</sub>≈0...
June 27, 2016: Optics Express
Abe DeAnda, Eugene A Grossi, Leora B Balsam, Marc R Moon, Clifford W Barlow, Daniel O Navia, Patricia Ursomanno, Bulat A Ziganshin, Annette E Rabinovich, John A Elefteriades, Julian A Smith
BACKGROUND: Seasonal variations of Stanford Type A dissections (STADs) have been previously described in the Northern Hemisphere (NH). This study sought to determine if these variation are mirrored in the Southern Hemisphere (SH). METHODS: Data from patients treated surgically for STADs were retrospectively obtained from existing administrative and clinical databases from NH and SH sites. Data points of interest included age, sex, date of dissection, and 30-day mortality...
December 2015: Aorta (Stamford, Conn.)
Iván Dueñas-Espín, Heleen Demeyer, Elena Gimeno-Santos, Michael I Polkey, Nicholas S Hopkinson, Roberto A Rabinovich, Fabienne Dobbels, Niklas Karlsson, Thierry Troosters, Judith Garcia-Aymerich
BACKGROUND: The role of anxiety and depression in the physical activity (PA) of patients with COPD is controversial. We prospectively assessed the effect of symptoms of anxiety and depression on PA in COPD patients. METHODS: We evaluated anxiety and depression (Hospital Anxiety and Depression Scale [HADS]), PA (Dynaport(®) accelerometer), and other relevant characteristics in 220 COPD patients from five European countries at baseline and at 6 and 12 months of follow-up...
2016: International Journal of Chronic Obstructive Pulmonary Disease
Marise L Fermino, L Sebastian D Dylon, Nerry T Cecílio, Sofia N Santos, Marta A Toscano, Marcelo Dias-Baruffi, Maria C Roque-Barreira, Gabriel A Rabinovich, Emerson S Bernardes
Galectin-3, an endogenous glycan-binding protein, is abundantly expressed at sites of inflammation and immune cell activation. Although this lectin has been implicated in the control of T helper (Th) polarization, the mechanisms underlying this effect are not well understood. Here, we investigated the role of endogenous galectin-3 during the course of experimental Leishmania major infection using galectin-3-deficient (Lgals3(-/-)) mice in a BALB/c background and the involvement of Notch signaling pathway in this process...
August 2016: Molecular Immunology
Ada G Blidner, Karina V Mariño, Gabriel A Rabinovich
Engineering T cells with chimeric antigen receptors (CARs) has demonstrated remarkable success in eradicating hematological malignancies. In this issue of Immunity, June and colleagues demonstrate the broad antitumor efficacy of a newly-designed CAR targeting the O-linked hypoglycosylated epitopes Tn and sialyl-Tn on cancer-associated MUC-1.
June 21, 2016: Immunity
Sheila T Angeles-Han, Consuelo Egla Rabinovich
PURPOSE OF REVIEW: The review provides updates on novel risk markers for the development of pediatric inflammatory uveitis and a severe disease course, on treatment of refractory disease, and on the measurement of visual outcomes. RECENT FINDINGS: There are several new genetic markers, biomarkers, and clinical factors that may influence a child's uveitis disease course. It is important to identify children at risk for poor visual outcomes and who are refractory to traditional therapy...
September 2016: Current Opinion in Rheumatology
Jorge Rabinovich
No abstract text is available yet for this article.
July 19, 2016: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
Héctor R Quintá, Carlos Wilson, Ada G Blidner, Christian González-Billault, Laura A Pasquini, Gabriel A Rabinovich, Juana M Pasquini
UNLABELLED: Axonal growth cone collapse following spinal cord injury (SCI) is promoted by semaphorin3A (Sema3A) signaling via PlexinA4 surface receptor. This interaction triggers intracellular signaling events leading to increased hydrogen peroxide levels which in turn promote filamentous actin (F-actin) destabilization and subsequent inhibition of axonal re-growth. In the current study, we demonstrated that treatment with galectin-1 (Gal-1), in its dimeric form, promotes a decrease in hydrogen peroxide (H2O2) levels and F-actin repolimerization in the growth cone and in the filopodium of neuron surfaces...
September 2016: Experimental Neurology
Pablo Varona, Mikhail I Rabinovich
Traditional studies on the interaction of cognitive functions in healthy and disordered brains have used the analyses of the connectivity of several specialized brain networks-the functional connectome. However, emerging evidence suggests that both brain networks and functional spontaneous brain-wide network communication are intrinsically dynamic. In the light of studies investigating the cooperation between different cognitive functions, we consider here the dynamics of hierarchical networks in cognitive space...
June 15, 2016: Proceedings. Biological Sciences
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