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https://www.readbyqxmd.com/read/28091894/mechanisms-of-action-of-surgical-interventions-on-weight-related-diseases-the-potential-role-of-bile-acids
#1
REVIEW
Mohsen Mazidi, Pedro Paulo P de Caravatto, John R Speakman, Ricardo V Cohen
Surgical interventions for weight-related diseases (SWRD) may have substantial and sustainable effect on weight reduction, also leading to a higher remission rate of type 2 diabetes (T2D) mellitus than any other medical treatment or lifestyle intervention. The resolution of T2D after Roux-en-Y gastric bypass (RYGB) typically occurs too quickly to be accounted for by weight loss alone, suggesting that these operations have a direct impact on glucose homeostasis. The mechanisms underlying these beneficial effects however remain unclear...
January 14, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28091851/operative-treatments-for-reflux-after-bariatric-surgery-current-and-emerging-management-options
#2
Daniela Treitl, Derek Nieber, Kfir Ben-David
Gastroesophageal reflux disease (GERD) is a common disorder that has a well-established connection with obesity. To ameliorate the morbidity associated with obesity, bariatric procedures have become an established pathway to accomplish sustained weight loss. In some procedures, such as with the Roux-en-Y gastric bypass surgery, weight loss is also accompanied by the resolution of GERD symptoms. However, other popular bariatric surgeries, such as the sleeve gastrectomy, have a controversial impact on their effect on reflux...
January 13, 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/28089590/using-the-presurgical-psychological-evaluation-to-predict-5-year-weight-loss-outcomes-in-bariatric-surgery-patients
#3
Ryan J Marek, Yossef S Ben-Porath, Manfred H M van Dulmen, Kathleen Ashton, Leslie J Heinberg
BACKGROUND: Psychosocial factors contribute to poorer weight loss outcomes following bariatric surgery; however, findings on associations between preoperative psychiatric diagnoses, psychological testing, and weight loss are inconsistent. OBJECTIVES: Examine associations between presurgical psychiatric diagnoses derived from a semi-structured clinical interview and test scores from the Minnesota Multiphasic Personality-Inventory-2 - Restructured Form (MMPI-2-RF) and 5-year Body Mass Index (BMI) outcomes...
November 11, 2016: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/28077412/microvascular-outcomes-after-metabolic-surgery-moms-in-patients-with-type-2-diabetes-mellitus-and-class-i-obesity-rationale-and-design-for-a-randomised-controlled-trial
#4
Ricardo Vitor Cohen, Tiago Veiga Pereira, Cristina Mamédio Aboud, Pedro Paulo de Paris Caravatto, Tarissa Beatrice Zanata Petry, José Luis Lopes Correa, Carlos Aurélio Schiavon, Mariangela Correa, Carlos Eduardo Pompílio, Fernando Nogueira Quirino Pechy, Carel le Roux
INTRODUCTION: There are several randomised controlled trials (RCTs) that have already shown that metabolic/bariatric surgery achieves short-term and long-term glycaemic control while there are no level 1A of evidence data regarding the effects of surgery on the microvascular complications of type 2 diabetes mellitus (T2DM). PURPOSE: The aim of this trial is to investigate the long-term efficacy and safety of the Roux-en-Y gastric bypass (RYGB) plus the best medical treatment (BMT) versus the BMT alone to improve microvascular outcomes in patients with T2DM with a body mass index (BMI) of 30-34...
January 11, 2017: BMJ Open
https://www.readbyqxmd.com/read/28070477/the-longitudinal-trajectory-of-post-surgical-total-weight-loss-among-middle-aged-women-who-had-undergone-bariatric-surgery
#5
Dong-Chul Seo, Chung Gun Lee, Mohammad R Torabi, David K Lohrmann
Middle-aged women are at a higher risk of being obese. We examined the trajectory of post-surgical % total weight loss (%TWL) among middle-aged female bariatric patients. We fitted sequential generalized estimating equations models to analyze a sample of women who received bariatric surgery in 1995-2012, aged 40-65 years at the time of surgery (N = 158,292) whose pre-operative body mass index (BMI) was ≥ 30 kg/m(2) in the Bariatric Outcomes Longitudinal Database. The %TWL computed by 100% × (pre-surgery BMI - post-surgery BMI) / pre-surgery BMI showed different trajectories depending on type of surgery...
March 2017: Preventive Medicine Reports
https://www.readbyqxmd.com/read/28065736/long-term-outcomes-of-bariatric-surgery-in-adolescents-with-severe-obesity-fabs-5-a-prospective-follow-up-analysis
#6
Thomas H Inge, Todd M Jenkins, Stavra A Xanthakos, John B Dixon, Stephen R Daniels, Meg H Zeller, Michael A Helmrath
BACKGROUND: Little is known about the long-term outcomes of bariatric surgery for severe adolescent obesity, raising questions about the durability of early responses to surgery. We aimed to analyse long-term (>5 years) outcomes of Roux-en-Y gastric bypass in a cohort of young adults who had undergone the operation during adolescence, in the Follow-up of Adolescent Bariatric Surgery at 5 Plus Years (FABS-5+) extension study. METHODS: A cohort of young people aged 13-21 years underwent Roux-en-Y gastric bypass for clinically severe obesity at a paediatric academic medical centre in the USA...
January 5, 2017: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/28065734/laparoscopic-roux-en-y-gastric-bypass-in-adolescents-with-severe-obesity-amos-a-prospective-5-year-swedish-nationwide-study
#7
Torsten Olbers, Andrew J Beamish, Eva Gronowitz, Carl-Erik Flodmark, Jovanna Dahlgren, Gustaf Bruze, Kerstin Ekbom, Peter Friberg, Gunnar Göthberg, Kajsa Järvholm, Jan Karlsson, Staffan Mårild, Martin Neovius, Markku Peltonen, Claude Marcus
BACKGROUND: Severe obesity in adolescence is associated with reduced life expectancy and impaired quality of life. Long-term benefits of conservative treatments in adolescents are known to be modest, whereas short-term outcomes of adolescent bariatric surgery are promising. We aimed to compare 5-year outcomes of adolescent surgical patients after Roux-en-Y gastric bypass with those of conservatively treated adolescents and of adults undergoing Roux-en-Y gastric bypass, in the Adolescent Morbid Obesity Surgery (AMOS) study...
January 5, 2017: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/28063112/conversion-of-sleeve-gastrectomy-to-roux-en-y-gastric-bypass-is-effective-for-gastro-oesophageal-reflux-disease-but-not-for-further-weight-loss
#8
Chetan D Parmar, Kamal K Mahawar, Maureen Boyle, Norbert Schroeder, Shlok Balupuri, Peter K Small
INTRODUCTION: Inadequate weight loss (IWL)/weight regain (WR) and gastro-esophageal reflux disease (GERD), unresponsive to medical management, are two most common indications for conversion of sleeve gastrectomy (SG) to Roux-en-Y gastric bypass (RYGB). This study reports detailed outcomes of conversion of SG to RYGB for these two indications separately. METHODS: We interrogated our prospectively maintained database to identify patients who underwent a conversion of their SG to RYGB in our unit...
January 6, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28054294/treatment-of-common-bile-duct-stones-in-gastric-bypass-patients-with-laparoscopic-transgastric-endoscopic-retrograde-cholangiopancreatography
#9
Nina A Frederiksen, Louise Tveskov, Frederik Helgstrand, Lars Naver, Andrea Floyd
BACKGROUND: Laparoscopic Roux-en-Y gastric bypass excludes the biliary tree from traditional evaluation and treatment with endoscopic retrograde cholangiopancreatography (ERCP). Due to the initial rapid weight loss, gastric bypass patients have an increased risk of developing gallstones in the gallbladder as well as in the common bile duct. Various techniques to access the biliary tree have been described. The techniques are characterised by complexity and varying results. The aim of the present study was to assess both feasibility and outcome of laparoscopic-assisted transgastric ERCP in patients with gastric bypass...
January 4, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28035521/postoperative-outcomes-of-laparoscopic-bariatric-surgery-in-older-obese-patients-a-matched-case-control-study
#10
Damien Bergeat, David Lechaux, Adil Ghaina, Ronan Thibault, Vianney Bouygues
BACKGROUND: Laparoscopic bariatric surgery (LBS) in older obese patients remains debated regarding postoperative outcomes. OBJECTIVES: The aim of this case-control study is to evaluate global results of LBS in patients ≥60 years (yr) with a matched case control study. METHODS: All patients ≥60 years who benefited from LBS in our center between January 2009 and January 2014 were included in this retrospective study. They were matched (1:2) to patients <40 and 40-59 years on BMI, surgical procedure and year, and history of previous LBS...
December 29, 2016: Obesity Surgery
https://www.readbyqxmd.com/read/28032663/technical-review-of-eus-guided-gastroenterostomy-in-2017
#11
REVIEW
Takao Itoi, Todd H Baron, Khashab Mouen, Takayoshi Tsuchiya, Shayan Irani, Vinay Dhir, Anthony Y B Teoh
Gastric outlet obstruction (GOO) which can be caused by benign and malignant diseases often leads to a reduction in patient quality of life. Lately endoscopic ultrasonography (EUS)-guided gastroenterostomy (EUS-GE) has emerged. At the present time, there are three types of EUS-GE using lumen-apposing biflanged metal stents (LAMS), i.e., direct EUS-GE, assisted EUS-GE using retrieval/dilating balloon, single balloon overtube, nasobiliary drain and untraslim endoscope, and EUS-guided double balloon occluded gastrojejunostomy bypass (EPASS)...
December 29, 2016: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/28028658/chronic-abdominal-pain-and-symptoms-5%C3%A2-years-after-gastric-bypass-for-morbid-obesity
#12
Ingvild K Høgestøl, Monica Chahal-Kummen, Inger Eribe, Cathrine Brunborg, Audun Stubhaug, Stephen Hewitt, Jon Kristinsson, Tom Mala
INTRODUCTION: Roux-en-Y gastric bypass (RYGB) is widely performed as treatment of morbid obesity. Long-term weight loss, effects on co-morbidities, and quality of life after RYGB have been well addressed. Other long-term outcomes are less elucidated. The aim of this study was to evaluate the prevalence, symptom characteristics, and possible predictors of chronic abdominal pain and gastrointestinal symptoms during consultations 5 years after RYGB. METHODS: A 5-year follow-up study of patients operated with RYGB 2008-2009 was performed...
December 27, 2016: Obesity Surgery
https://www.readbyqxmd.com/read/28017813/association-between-state-medical-malpractice-environment-and-postoperative-outcomes-in-the-united-states
#13
Christina A Minami, Catherine R Sheils, Emily Pavey, Jeanette W Chung, Jonah J Stulberg, David D Odell, Anthony D Yang, David J Bentrem, Karl Y Bilimoria
BACKGROUND: The U.S. medical malpractice system assumes that the threat of liability should deter negligence but it is unclear whether malpractice environment impacts healthcare quality. We thus sought to explore the association between state malpractice environment and post-operative complication rates. STUDY DESIGN: This observational study included Medicare fee-for-service beneficiaries undergoing one of the following surgeries in 2010: colorectal, lung, esophageal, or pancreatic resection, total knee arthroplasty, craniotomy, gastric bypass, abdominal aortic aneurysm repair, coronary artery bypass grafting, or cystectomy...
December 22, 2016: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/28008090/scaling-it-down-new-in-vitro-tools-to-get-the-balance-right
#14
Emma K Biggs, Fiona M Gribble, Frank Reimann
Treatments for diabetes and obesity based on enteroendocrine hormones are a focus of research interest, partly due to the successes of glucagon-like peptide-1 (GLP-1) mimetic peptides in the treatment of diabetes and the correlation of altered enteroendocrine profiles with the positive metabolic outcomes of gastric bypass surgery. It is thought that simultaneous stimulation of more than one receptor might mimic the superior efficacy of the latter and dual or triple-agonist peptides are under investigation. An important step in developing multiple agonists is to establish the relative pharmacological potency and efficacy of new molecules at its different target receptors, and to optimise the balance of activities to achieve the desired treatment outcome...
January 1, 2017: Biochemical Journal
https://www.readbyqxmd.com/read/28005639/pancreatic-uptake-by-18f-fdopa-pet-ct-in-patients-with-hypoglycemia-after-gastric-bypass-surgery-compared-with-controls-with-or-without-carbidopa-pretreatment
#15
André P van Beek, Loek J M de Heide, Bram van Ginkel, Riemer H J A Slart, Anouk N A van der Horst-Schrivers, Ronald Boellaard, Elisabeth G E de Vries, Walter Noordzij, Andor W J M Glaudemans
PURPOSE: The use of Fluorine-labeled dihydroxy-phenyl-alanine (F-FDOPA) PET/CT in patients with hypoglycemia suspected to be caused by pancreatic disease can be helpful to localize the source of excess insulin production. In this setting, carbidopa pretreatment is not recommended. However, quantitative comparisons of pancreatic tracer uptake in patients with or without carbidopa pretreatment and in diffuse pancreatic disease are lacking. Therefore, we aimed to describe and quantify pancreatic F-FDOPA uptake in patients without pancreatic disease with or without carbidopa pretreatment and in patients with hypoglycemia after gastric bypass surgery...
December 21, 2016: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28004304/changes-in-fasting-and-prandial-gut-and-adiposity-hormones-following-vertical-sleeve-gastrectomy-or-roux-en-y-gastric-bypass-an-18-month-prospective-study
#16
Naji Alamuddin, Marion L Vetter, Rexford S Ahima, Louise Hesson, Scott Ritter, Alyssa Minnick, Lucy F Faulconbridge, Kelly C Allison, David B Sarwer, Jesse Chittams, Noel N Williams, Matthew R Hayes, James W Loughead, Ruben Gur, Thomas A Wadden
BACKGROUND: Vertical sleeve gastrectomy (VSG) and Roux-en-Y gastric bypass (RYGB) produce substantial weight loss, both primarily through gastric restriction but with potentially different hormonal signaling. This prospective, observational study compared changes in gut-derived hormones in VSG, RYGB, and weight-stable participants at 6 and 18 months post-surgery. METHODS: Sixty-four obese, non-diabetic women, including 18 VSG, 23 RYGB, and 23 weight-stable controls completed assessments at baseline and 6 months, before and after consuming a mixed-nutrient meal; blood sampling occurred for 180 min post-meal...
December 21, 2016: Obesity Surgery
https://www.readbyqxmd.com/read/28002543/incidence-and-prognosis-of-psoriasis-and-psoriatic-arthritis-in-patients-undergoing-bariatric-surgery
#17
Alexander Egeberg, Jens Ahm Sørensen, Gunnar Hilmar Gislason, Filip Krag Knop, Lone Skov
Importance: Psoriasis and obesity are strongly linked, and weight loss appears to improve psoriasis symptoms and severity. Bariatric surgery may induce remission of psoriasis, but data are limited to small studies and case series. Objective: To examine the incidence and prognosis of psoriasis and psoriatic arthritis in patients undergoing bariatric surgery (gastric bypass and gastric banding). Design, Setting, and Participants: This population-based cohort study used individual-level linkage of administrative and public health registers in Denmark...
December 21, 2016: JAMA Surgery
https://www.readbyqxmd.com/read/27995516/roux-en-y-gastric-bypass-versus-sleeve-gastrectomy-as-revisional-procedures-after-adjustable-gastric-band-5-year-outcomes
#18
Luigi Angrisani, Antonio Vitiello, Antonella Santonicola, Ariola Hasani, Maurizio De Luca, Paola Iovino
INTRODUCTION: In 2013, a worldwide bariatric surgery survey showed that laparoscopic adjustable gastric banding (LAGB) has been abandoned in favor of laparoscopic sleeve gastrectomy (LSG) and laparoscopic Roux-en-y gastric bypass (LRYGBP). PURPOSE: The aim of this study was to compare results of LRYGBP and LSG performed as a revisional procedure after LAGB. MATERIALS AND METHODS: All patients converted from LAGB to LSG or to LRYGBP from January 2007 to December 2011 were included in the study...
December 19, 2016: Obesity Surgery
https://www.readbyqxmd.com/read/27986584/bariatric-surgery-in-morbidly-obese-patients-with-inflammatory-bowel-disease-a-systematic-review
#19
Saeed Shoar, Sayed Shahabuddin Hoseini, Mohammad Naderan, Habibollah Mahmoodzadeh, Fung Ying Man, Nasrin Shoar, Motahar Hosseini, Shahram Bagheri-Hariri
BACKGROUNDS: With increased prevalence of obesity, the number of inflammatory bowel disease (IBD) patients suffering from morbid obesity has raised. It is not clear yet if bariatric surgery is a safe and effective option in this population. OBJECTIVES: Our systematic review aims to summarize the available literature on the safety and efficacy of bariatric surgery in morbidly obese patients with IBD. SETTING: University hospital, Iran. METHODS: A PubMed/MEDLINE search was performed to identify studies reporting the outcome of morbidly obese IBD patients...
October 25, 2016: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/27986577/fast-track-bariatric-surgery-safety-of-discharge-on-the-first-postoperative-day-after-bariatric-surgery
#20
Zhamak Khorgami, Jacob A Petrosky, Amin Andalib, Ali Aminian, Philip R Schauer, Stacy A Brethauer
BACKGROUND: Fast track recovery pathways have resulted in a multidisciplinary approach to enhance postoperative recovery. OBJECTIVES: To assess feasibility and outcome of early discharge after laparoscopic sleeve gastrectomy (LSG) and laparoscopic Roux-en-Y gastric bypass (LRYGB). SETTING: The American College of Surgeons National Surgical Quality Improvement Program database was analyzed to identify patients with body mass index≥35 kg/m(2) who underwent LSG or LRYGB in 2012 and 2013...
February 2, 2016: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
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