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Accessory pathway

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https://www.readbyqxmd.com/read/29044715/bayesian-genome-wide-association-analysis-for-body-weight-in-farmed-atlantic-salmon-salmo-salar-l
#1
G M Yoshida, J P Lhorente, R Carvalheiro, J M Yáñez
We performed a genome-wide association study to detect markers associated with growth traits in Atlantic salmon. The analyzed traits included body weight at tagging (BWT) and body weight at 25 months (BW25M). Genotypes of 4662 animals were imputed from the 50K SNP chip to the 200K SNP chip using fimpute software. The markers were simultaneously modeled using Bayes C to identify genomic regions associated with the traits. We identified windows explaining a maximum of 3.71% and 3.61% of the genetic variance for BWT and BW25M respectively...
October 17, 2017: Animal Genetics
https://www.readbyqxmd.com/read/29036312/safety-and-efficacy-of-cryoablation-vs-radiofrequency-ablation-of-septal-accessory-pathways-systematic-review-of-the-literature-and-meta-analyses
#2
Loreto Bravo, Felipe Atienza, Gabriel Eidelman, Pablo Ávila, Mauricio Pelliza, Evaristo Castellanos, Gerard Loughlin, Tomás Datino, Esteban G Torrecilla, Jesús Almendral, Pedro Luis Sánchez, Ángel Arenal, Nieves Martínez-Alzamora, Francisco Fernández-Avilés
Aims: Radiofrequency ablation (RFA) of septal accessory pathways (APs) is associated with a significant rate of first procedure failures and complications. Cryoablation is an alternative energy source but there are no studies comparing both ablation techniques. We aimed to systematically review the literature and compare the efficacy and safety of cryoablation vs. RFA of septal APs. Methods and results: We conducted two separate meta-analysis of cryoablation and RFA of septal APs and calculated the global estimates of the efficacy and safety...
October 3, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/29029399/a-cellular-platform-for-the-evaluation-of-immune-checkpoint-molecules
#3
Sabrina Jutz, Annika Hennig, Wolfgang Paster, Ömer Asrak, Dejana Dijanovic, Florian Kellner, Winfried F Pickl, Johannes B Huppa, Judith Leitner, Peter Steinberger
Blockade of the T cell coinhibitory molecules CTLA-4 and PD-1 has clinical utility to strengthen T cell responses. In addition to these immune checkpoints an ever-growing number of molecules has been implicated in generating coinhibitory signals in T cells. However, investigating coinhibitory molecules in primary human cells is complicated by the restricted expression and promiscuity of both coinhibitory receptors and their ligands. Here we have evaluated the potential of fluorescence-based transcriptional reporters based on the human Jurkat T cell line in conjunction with engineered T cell stimulator cell lines for investigating coinhibitory pathways...
September 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29016834/the-effect-of-ventricular-pre-excitation-on-ventricular-wall-motion-and-left-ventricular-systolic-function
#4
ChenCheng Dai, BaoJing Guo, WenXiu Li, YanYan Xiao, Mei Jin, Ling Han, JianZeng Dong
Aims: The relationship between ventricular pre-excitation and left ventricular dysfunction has been described in the absence of sustained supraventricular tachycardia in a series of case reports. There have been no systematic studies about the effect of ventricular pre-excitation with different accessory pathway locations on ventricular wall motion and left ventricular (LV) systolic function. Methods and results: Thirty patients were selected for each of 4 groups, including those with right septal pathways (Group 1), right free-wall pathways (Group 2), left free-wall pathways (Group 3), and non-pre-excited patients undergoing electrophysiological evaluation for supraventricular tachycardia...
August 9, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28989287/congenitally-corrected-transposition-of-great-vessels-with-infundibular-pulmonary-stenosis-with-ventricular-septal-defect-presenting-with-atypical-atrioventricular-nodal-reentrant-tachycardia-a-rare-association
#5
Ashwin Kodliwadmath
Congenitally corrected transposition of great vessels (CCTGV) is a rare congenital heart disease (CHD) accounting for <1% of CHDs. CCTGV with infundibular pulmonary stenosis (PS) with ventricular septal defect (VSD) is part of Fallot's physiology. It is known to be associated with bradyarrhythmias like atrioventricular (AV) blocks, and acquired complete AV block occurs at a rate of 2% per year. Patients can have left-sided accessory pathways, which may cause atrioventricular reentrant tachycardia (AVRT)...
2017: International Medical Case Reports Journal
https://www.readbyqxmd.com/read/28974231/clca1-suppresses-colorectal-cancer-aggressiveness-via-inhibition-of-the-wnt-beta-catenin-signaling-pathway
#6
Xiaofen Li, Wangxiong Hu, Jiaojiao Zhou, Yanqin Huang, Jiaping Peng, Ying Yuan, Jiekai Yu, Shu Zheng
BACKGROUND: Chloride channel accessory 1 (CLCA1) belongs to the calcium-sensitive chloride conductance protein family, which is mainly expressed in the colon, small intestine and appendix. This study was conducted to investigate the functions and mechanisms of CLCA1 in colorectal cancer (CRC). METHODS: The CLCA1 protein expression level in CRC patients was evaluated by enzyme-linked immunosorbent assay (ELISA), immunohistochemistry (IHC), and western blotting analysis...
October 3, 2017: Cell Communication and Signaling: CCS
https://www.readbyqxmd.com/read/28969539/transseptal-access-to-the-left-atrium-tips-and-tricks-to-keep-it-safe-derived-from-single-operator-experience-and-review-of-the-literature
#7
Antonis S Manolis
BACKGROUND: Transseptal puncture (TSP) remains a demanding procedural step in accessing the left atrium with inherent risks and safety concerns, mostly related to cardiac tamponade. OBJECTIVE: Based on our own experience with 249 TSP procedures and in-depth literature review, we present our results and offer several tips and tricks that may render TSP successful and safe. METHODS: This prospective study comprised 249 consecutive patients (146 men), aged 41...
September 27, 2017: Current Cardiology Reviews
https://www.readbyqxmd.com/read/28960358/lipid-remodeling-in-neuroendocrine-secretion
#8
REVIEW
Stéphane Gasman, Nicolas Vitale
Neuroendocrine cells secrete hormones and polypeptides through a complex membrane trafficking process that involves the transport of specific organelles, called large dense core secretory granules, from the Golgi apparatus to specialized sites at the plasma membrane where these vesicles are successively exocytosed and recaptured by endocytosis through tightly coupled reactions. The minimal machinery required for exocytosis has been defined as SNARE proteins associated with few accessory proteins. On the other side, clathrin and dynamin constitute major components of some of the most important endocytotic pathways...
September 27, 2017: Biology of the Cell
https://www.readbyqxmd.com/read/28955331/molecular-analysis-of-a-short-term-model-of-%C3%AE-glucans-trained-immunity-highlights-the-accessory-contribution-of-gm-csf-in-priming-mouse-macrophages-response
#9
Sarah Walachowski, Guillaume Tabouret, Marion Fabre, Gilles Foucras
β-Glucans (BGs) are glucose polymers present in the fungal cell wall (CW) and, as such, are recognized by innate immune cells as microbial-associated pattern through Dectin-1 receptor. Recent studies have highlighted the ability of the pathogenic yeast Candida albicans or its CW-derived β(1,3) (1,6)-glucans to increase human monocytes cytokine secretion upon secondary stimulation, a phenomenon now referred as immune training. This ability of monocytes programming confers BGs an undeniable immunotherapeutic potential...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28946621/canonical-and-non-canonical-autophagy-in-hiv-1-replication-cycle
#10
REVIEW
Olivier Leymarie, Leslie Lepont, Clarisse Berlioz-Torrent
Autophagy is a lysosomal-dependent degradative process essential for maintaining cellular homeostasis, and is a key player in innate and adaptive immune responses to intracellular pathogens such as human immunodeficiency virus type 1 (HIV-1). In HIV-1 target cells, autophagy mechanisms can (i) selectively direct viral proteins and viruses for degradation; (ii) participate in the processing and presentation of viral-derived antigens through major histocompatibility complexes; and (iii) contribute to interferon production in response to HIV-1 infection...
September 23, 2017: Viruses
https://www.readbyqxmd.com/read/28940905/double-atrial-potentials-in-left-sided-accessory-pathways-are-associated-with-paroxysmal-atrial-fibrillation
#11
Krzysztof Błaszyk, Adrian Gwizdała, Michał Waśniewski, Jarosław Hiczkiewicz, Wojciech Seniuk, Michał Michalak
INTRODUCTION: Muscular connections between the coronary sinus (CS) and left atrium probably impact distribution of electrical activity. Double atrial potentials (DP) may be their presentation. The aim was to investigate the presence of DP in CS recordings during atrioventricular reentrant tachycardia (AVRT) and its contribution to the occurrence of paroxysmal atrial fibrillation (AF). METHODS: A group of 247 patients with accessory pathways (AP) were screened for DP...
September 22, 2017: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/28936205/homologous-recombination-in-protozoan-parasites-and-recombinase-inhibitors
#12
REVIEW
Andrew A Kelso, Sarah M Waldvogel, Adam J Luthman, Michael G Sehorn
Homologous recombination (HR) is a DNA double-strand break (DSB) repair pathway that utilizes a homologous template to fully repair the damaged DNA. HR is critical to maintain genome stability and to ensure genetic diversity during meiosis. A specialized class of enzymes known as recombinases facilitate the exchange of genetic information between sister chromatids or homologous chromosomes with the help of numerous protein accessory factors. The majority of the HR machinery is highly conserved among eukaryotes...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28934377/the-environmental-acinetobacter-baumannii-isolate-dsm30011-reveals-clues-into-the-preantibiotic-era-genome-diversity-virulence-potential-and-niche-range-of-a-predominant-nosocomial-pathogen
#13
Guillermo D Repizo, Alejandro M Viale, Vítor Borges, María M Cameranesi, Najwa Taib, Martín Espariz, Céline Brochier-Armanet, João Paulo Gomes, Suzana P Salcedo
Acinetobacter baumannii represents nowadays an important nosocomial opportunistic pathogen whose reservoirs outside the clinical setting are obscure. Here, we traced the origins of the collection strain A. baumannii DSM30011 to an isolate first reported in 1944, obtained from the enriched microbiota responsible of the aerobic decomposition of the resinous desert shrub guayule. Whole-genome sequencing and phylogenetic analysis based on core genes confirmed DSM30011 affiliation to A. baumannii. Comparative studies with 32 complete A...
September 1, 2017: Genome Biology and Evolution
https://www.readbyqxmd.com/read/28931039/abnormalities-in-substance-p-neurokinin-1-receptor-binding-in-key-brainstem-nuclei-in-sudden-infant-death-syndrome-related-to-prematurity-and-sex
#14
Fiona M Bright, Robert Vink, Roger W Byard, Jhodie R Duncan, Henry F Krous, David S Paterson
Sudden infant death syndrome (SIDS) involves failure of arousal to potentially life threatening events, including hypoxia, during sleep. While neuronal dysfunction and abnormalities in neurotransmitter systems within the medulla oblongata have been implicated, the specific pathways associated with autonomic and cardiorespiratory failure are unknown. The neuropeptide substance P (SP) and its tachykinin neurokinin-1 receptor (NK1R) have been shown to play an integral role in the modulation of homeostatic function in the medulla, including regulation of respiratory rhythm generation, integration of cardiovascular control, and modulation of the baroreceptor reflex and mediation of the chemoreceptor reflex in response to hypoxia...
2017: PloS One
https://www.readbyqxmd.com/read/28928979/ablation-of-a-left-sided-accessory-pathway-with-near-zero-fluoroscopy-in-a-9-year-old-boy
#15
Gabriel Cismaru, Lucian Muresan, Mihai Puiu, Radu Rosu, Gabriel Gusetu, Dana Pop, Dumitru Zdrenghea
Catheter ablation of cardiac arrhythmias in pediatric population is associated with the risk of ionizing radiation on the child. Due to a greater radiation sensitivity in children and a longer life expectancy newer techniques try to reduce the radiation exposure. A new technique for zero-fluoroscopy catheter ablation is described in a 9-year-old boy who had a left-sided concealed accessory pathway. The NAVX Ensite 3D mapping system permits catheter placement inside the venous system and movement inside the heart chambers without the use of X-rays...
September 2017: Oxford Medical Case Reports
https://www.readbyqxmd.com/read/28912444/pan-genomic-and-transcriptomic-analyses-of-leuconostoc-mesenteroides-provide-insights-into-its-genomic-and-metabolic-features-and-roles-in-kimchi-fermentation
#16
Byung Hee Chun, Kyung Hyun Kim, Hye Hee Jeon, Se Hee Lee, Che Ok Jeon
The genomic and metabolic features of Leuconostoc (Leu) mesenteroides were investigated through pan-genomic and transcriptomic analyses. Relatedness analysis of 17 Leu. mesenteroides strains available in GenBank based on 16S rRNA gene sequence, average nucleotide identity, in silico DNA-DNA hybridization, molecular phenotype, and core-genome indicated that Leu. mesenteroides has been separated into different phylogenetic lineages. Pan-genome of Leu. mesenteroides strains, consisting of 999 genes in core-genome, 1,432 genes in accessory-genome, and 754 genes in unique genome, and their COG and KEGG analyses showed that Leu...
September 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28901670/specificity-of-wide-qrs-complex-tachycardia-criteria-and-algorithms-in-patients-with-ventricular-preexcitation
#17
Marek Jastrzębski, Paweł Moskal, Piotr Kukla, Kamil Fijorek, Roksana Kisiel, Danuta Czarnecka
BACKGROUND: Despite substantial progress in the field of differentiation between ventricular tachycardia (VT) and supraventricular tachycardia (SVT) with wide QRS complexes, differentiation between VT and preexcited SVT remains largely unresolved due to significant overlap in QRS morphology. Our aim was to assess the specificities of various single ECG criteria and sets of criteria (Brugada algorithm, aVR algorithm, Steurer algorithm, and the VT score) for diagnosis of VT in a sizable cohort of patients with preexcitation...
September 12, 2017: Annals of Noninvasive Electrocardiology
https://www.readbyqxmd.com/read/28893294/hiv-i-nef-inhibitors-a-novel-class-of-hiv-specific-immune-adjuvants-in-support-of-a-cure
#18
REVIEW
Gregory A Dekaban, Jimmy D Dikeakos
The success of many current vaccines relies on a formulation that incorporates an immune activating adjuvant. This will hold true for the design of a successful therapeutic HIV vaccine targeted at controlling reactivated virus following cessation of combined antiretroviral therapy (cART). The HIV accessory protein Nef functions by interfering with HIV antigen presentation through the major histocompatibility complex I (MHC-I) pathway thereby suppressing CD8(+) cytotoxic T cell (CTL)-mediated killing of HIV infected cells...
September 12, 2017: AIDS Research and Therapy
https://www.readbyqxmd.com/read/28886869/immunohistochemical-study-of-arginases-1-and-2-in-the-olfactory-bulbs-of-the-korean-roe-deer-capreolus-pygargus
#19
Jeongtae Kim, Meejung Ahn, Yuna Choi, Ji-Yeon Hyeon, Taekyun Shin
Arginases are enzymes of the urea cycle that catalyze the hydrolysis of l-arginine to ornithine and urea. The enzymes are core components of the arginine-ornithine-glutamate-γ-amino butyric acid pathway of the central nervous system. In the present study, we immunohistochemically determined the localization of arginase 1 and 2 in the olfactory bulb (OB) of the roe dear (Capreolus pygargus). Reverse transcription PCR revealed that the mRNAs encoding both arginase 1 and 2 were expressed in the OB. Arginase 1 was localized to olfactory nerve axons, calcitonin gene-related peptide-positive mitral/tufted cells (excitatory neurons), and glutamate acid decarboxylase 65/67-immunopositive periglomerular cells of the main olfactory bulb...
September 5, 2017: Acta Histochemica
https://www.readbyqxmd.com/read/28862781/effects-of-lateral-olfactory-tract-stimulation-on-fos-immunoreactivity-in-vasopressin-neurons-of-the-rat-piriform-cortex
#20
Chiharu Tsuji, Takahiro Tsuji, Andrew Allchorne, Gareth Leng, Mike Ludwig
In the main olfactory system, odours are registered at the main olfactory epithelium, then processed at the main olfactory bulb (MOB) and subsequently by the anterior olfactory nucleus (AON), the piriform cortex (PC) and the cortical amygdala. Previously, we reported populations of vasopressin neurons in different areas of the rat olfactory system, including the MOB, accessory olfactory bulb (AOB) and the AON and showed that these are involved in the coding of social odour information. Utilizing immunohistochemistry and a transgenic rat in which an enhanced green fluorescent protein reporter gene is expressed in vasopressin neurons (eGFP-vasopressin), we show here a population of vasopressin neurons in the PC...
September 1, 2017: Journal of Neuroendocrinology
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