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Accessory pathway

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https://www.readbyqxmd.com/read/29452709/late-restored-cardiac-function-after-successful-resynchronization-by-right-posterior-accessory-pathway-ablation-in-wolff-parkinson-white-syndrome-associated-dilated-cardiomyopathy
#1
Kun-Lang Wu, Shuenn-Nan Chiu, Chun-An Chen, Chun-Wei Lu, Wei-Chieh Tseng, Jou-Kou Wang, Mei-Hwan Wu
No abstract text is available yet for this article.
February 8, 2018: Journal of Electrocardiology
https://www.readbyqxmd.com/read/29444846/differential-immune-gene-expression-in-sperm-storage-organs-of-leaf-cutting-ants
#2
Sarah Chérasse, Boris Baer, Morten Schiøtt, Jacobus J Boomsma
Leaf-cutting ant queens mate with multiple males during a single nuptial flight and store sperm for up to two decades. During mating, males transfer sperm from their accessory testes to the queen bursa copulatrix from where it enters the spermatheca, an insect sperm storage organ that has become highly specialised in long-lived ant queens who never re-mate later in life. Long-term storage without the possibility to obtain new sperm creates an immune defence dilemma, because recognition of non-self cells eliminates infections but may also target irreplaceable sperm and reduce lifetime reproductive success...
February 14, 2018: Journal of Experimental Biology
https://www.readbyqxmd.com/read/29444369/rotaviral-non-structural-protein-4-triggers-dynamin-related-protein-1-dependent-mitochondrial-fragmentation-during-infection
#3
Arpita Mukherjee, Upayan Patra, Rahul Bhowmick, Mamta Chawla-Sarkar
Dynamic equilibrium between mitochondrial fission and mitochondrial fusion serves as an important quality control system within cells ensuring cellular vitality and homeostasis. Viruses often target mitochondrial dynamics as a part of their obligatory cellular reprogramming. The present study was undertaken to assess the status and regulation of mitochondrial dynamics during rotavirus (RV) infection. Distinct fragmentation of mitochondrial syncytia was observed during late hours of RV (SA11, Wa, A5-13) infection...
February 14, 2018: Cellular Microbiology
https://www.readbyqxmd.com/read/29430734/gaba-and-serotonin-expressing-neurons-take-part-in-inhibitory-as-well-as-excitatory-input-pathways-to-the-circadian-clock-of-the-madeira-cockroach-rhyparobia-maderae
#4
Maria Giese, Julia Gestrich, Azar Massah, Jonas Peterle, HongYing Wei, Monika Stengl
In the Madeira cockroach pigment-dispersing factor-immunoreactive (PDF-ir) neurons innervating the circadian clock, the accessory medulla (AME) in the brain's optic lobes, control circadian behavior. Circadian activity rhythms are entrained to daily light-dark cycles only by compound eye photoreceptors terminating in the lamina and medulla. Still, it is unknown which neurons connect the photoreceptors to the clock to allow for light-entrainment. Here, we characterized by multiple-label immunocytochemistry the serotonin (5-HT)-ir anterior fiber fan and GABA-ir pathways connecting the AME- and optic lobe neuropils...
February 11, 2018: European Journal of Neuroscience
https://www.readbyqxmd.com/read/29424737/catheter-ablation-of-manifest-posteroseptal-accessory-pathway-associated-with-coronary-sinus-diverticula-in-a-child-with-congenitally-corrected-transposition-of-the-great-arteries
#5
Yakup Ergül, Osman Esen, Senem Özgür, Alper Güzeltaş
No abstract text is available yet for this article.
February 2018: Anatolian Journal of Cardiology
https://www.readbyqxmd.com/read/29422602/acidic-organelles-mediate-tgf-%C3%AE-1-induced-cellular-fibrosis-via-pro-renin-receptor-and-vacuolar-atpase-trafficking-in-human-peritoneal-mesothelial-cells
#6
Ikuko Oba-Yabana, Takefumi Mori, Chika Takahashi, Takuo Hirose, Yusuke Ohsaki, Satoshi Kinugasa, Yoshikazu Muroya, Emiko Sato, Geneviève Nguyen, Rémi Piedagnel, Pierre M Ronco, Kazuhito Totsune, Sadayoshi Ito
TGF-β1, which can cause renal tubular injury through a vacuolar-type H+-ATPase (V-ATPase)-mediated pathway, is induced by the glucose degradation product methylglyoxal to yield peritoneal injury and fibrosis. The present study investigated the roles of V-ATPase and its accessory protein, the (pro)renin receptor, in peritoneal fibrosis during peritoneal dialysis. Rats daily administered 20 mM methylglyoxal intraperitoneally developed significant peritoneal fibrosis after 7 days with increased expression of TGF-β and V-ATPase, which was reduced by the inhibition of V-ATPase with co-administration of 100 mM bafilomycin A1...
February 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29409165/frequency-of-an-accessory-popliteal-efferent-lymphatic-pathway-in-dogs
#7
Monique N Mayer, Katherine A Sweet, Michael N Patsikas, Sally L Sukut, Cheryl L Waldner
Staging and therapeutic planning for dogs with malignant disease in the popliteal lymph node are based on the expected patterns of lymphatic drainage from the lymph node. The medial iliac lymph nodes are known to receive efferent lymph from the popliteal lymph node; however, an accessory popliteal efferent pathway with direct connection to the sacral lymph nodes has also been less frequently reported. The primary objective of this prospective, anatomic study was to describe the frequency of various patterns of lymphatic drainage of the popliteal lymph node...
February 6, 2018: Veterinary Radiology & Ultrasound
https://www.readbyqxmd.com/read/29406997/subcutaneous-accessory-pain-system-saps-a-novel-pain-pathway-for-myofascial-trigger-points
#8
Haytham Eloqayli
Despite the accumulating neuro-physiological evidence of myofascial pain, many clinicians are skeptical about its existence as a separate disease entity. No single theory can fully explain the four cardinal features of MPS; taut bands, local tenderness, local twitching and the characteristic pattern of referred pain. Bridging the gap between basic and clinical knowledge mandates coupling the local trigger point changes with the clinically seen distant somatically innervated referred pain. The main question addressed by the present theory is why do trigger points behave differently in comparison to the surrounding muscle tissue and are trigger points the primary problem or secondary to a primary pathology...
February 2018: Medical Hypotheses
https://www.readbyqxmd.com/read/29401065/cervical-vestibular-evoked-myogenic-potential-in-hypoglossal-nerve-schwannoma-a-case-report
#9
Aravind Kumar Rajasekaran, Amey Rajan Savardekar, Nagaraja Rao Shivashankar
BACKGROUND: Schwannoma of the hypoglossal nerve is rare. This case report documents an atypical abnormality of the cervical vestibular evoked myogenic potential (cVEMP) in a patient with schwannoma of the hypoglossal nerve. The observed abnormality was attributed to the proximity of the hypoglossal nerve to the spinal accessory nerve in the medullary cistern and base of the skull. PURPOSE: To report cVEMP abnormality in a patient with hypoglossal nerve schwannoma and provide an anatomical correlation for this abnormality...
February 2018: Journal of the American Academy of Audiology
https://www.readbyqxmd.com/read/29397525/coronary-sinus-morphology-in-pediatric-patients-with-supraventricular-tachycardia
#10
Matthew B Ambrose, Jennifer N Avari Silva, Michael Rudokas, Tammy M Bowman, Joshua Murphy, George F Van Hare
PURPOSE: The anatomic basis of atrioventricular node reentrant tachycardia (AVNRT) remains incompletely characterized in children. Differences in coronary sinus (CS) size and morphology have been observed in adults with AVNRT but have not been well characterized in children. METHODS: Children (< 18 years) brought to the EP lab with supraventricular tachycardia for ablation underwent CS venography. A blinded pediatric interventional cardiologist performed CS measurements, which were indexed to body surface area...
February 3, 2018: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
https://www.readbyqxmd.com/read/29385664/hydroxylation-of-resveratrol-with-doxa-in-vitro-an-enzyme-with-the-potential-for-the-bioconversion-of-a-bioactive-stilbene
#11
Hemraj Rimal, Sang-Cheol Yu, Joo-Ho Lee, Yamaguchi Tokutaro, Tae-Jin Oh
The late stage doxorubicin biosynthesis pathway acting enzyme from Streptomyces peucetius CYP129A2 (DoxA) exhibited substrate promiscuity towards stilbene group of compound such as resveratrol. DoxA along with two accessory enzymes ferrdoxin reductase and ferredoxin from spinach hydroxylated resveratrol at 3'-position in vitro to produce piceatannol. The product was identified by HPLC-PDA and high-resolution HR-qTOF-ESI/MS analyses in positive mode. The ESI/MS fragments resemble the hydroxylated product of resveratrol...
February 1, 2018: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29380334/mass-spectrometry-profiling-of-pituitary-glands
#12
Divya Krishnamurthy, Hassan Rahmoune, Paul C Guest
Many chronic diseases are associated with hypothalamic-pituitary-adrenal axis dysfunction. Therefore, proteomic profiling of the pituitary gland has potential to uncover new information on the underlying pathways affected in these conditions. This could lead to identification of new biomarkers or drug targets for development of novel therapeutics. Here we present a protocol for preparation of pituitary protein extracts and analysis of the major hormones and accessory proteins using liquid chromatography tandem mass spectrometry (LC-MS/MS)...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29374033/functional-expression-of-the-clostridium-ljungdahlii-acetyl-coa-synthase-in-clostridium-acetobutylicum-as-demonstrated-by-a-novel-in-vivo-co-exchange-activity-on-the-way-to-heterologous-installation-of-a-functional-wood-ljungdahl-pathway
#13
Alan G Fast, Eleftherios T Papoutsakis
Engineering the Wood-Ljungdahl pathway (WLP) in the established industrial organism Clostridium acetobutylicum would allow for the conversion of carbohydrates into butanol, acetone, and other metabolites at higher yields than is currently possible, while minimizing CO2 and H2 release. To this effect, we expressed 11 C. ljungdahlii core genes coding for enzymes and accessory proteins of the WLP in C. acetobutylicum The engineered WLP in C. acetobutylicum showed functionality of the Eastern branch of the pathway based on the formation of labeled 5,10-methylenetetrahydrofolate from 13C-labeled formate, as well as functionality of the Western branch as evidenced by the formation of CO from CO2 However, the lack of labeling in acetate and butyrate pools indicated that the connection between the two branches is not functional...
January 26, 2018: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29370303/mers-cov-4b-protein-interferes-with-the-nf-%C3%AE%C2%BAb-dependent-innate-immune-response-during-infection
#14
Javier Canton, Anthony R Fehr, Raúl Fernandez-Delgado, Francisco J Gutierrez-Alvarez, Maria T Sanchez-Aparicio, Adolfo García-Sastre, Stanley Perlman, Luis Enjuanes, Isabel Sola
Middle East respiratory syndrome coronavirus (MERS-CoV) is a novel human coronavirus that emerged in 2012, causing severe pneumonia and acute respiratory distress syndrome (ARDS), with a case fatality rate of ~36%. When expressed in isolation, CoV accessory proteins have been shown to interfere with innate antiviral signaling pathways. However, there is limited information on the specific contribution of MERS-CoV accessory protein 4b to the repression of the innate antiviral response in the context of infection...
January 25, 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29362235/the-ancient-link-between-g-protein-coupled-receptors-and-c-terminal-phospholipid-kinase-domains
#15
D Johan van den Hoogen, Harold J G Meijer, Michael F Seidl, Francine Govers
Sensing external signals and transducing these into intracellular responses requires a molecular signaling system that is crucial for every living organism. Two important eukaryotic signal transduction pathways that are often interlinked are G-protein signaling and phospholipid signaling. Heterotrimeric G-protein subunits activated by G-protein-coupled receptors (GPCRs) are typical stimulators of phospholipid signaling enzymes such as phosphatidylinositol phosphate kinases (PIPKs) or phospholipase C (PLC). However, a direct connection between the two pathways likely exists in oomycetes and slime molds, as they possess a unique class of GPCRs that have a PIPK as an accessory domain...
January 23, 2018: MBio
https://www.readbyqxmd.com/read/29361981/intraoperative-brief-electrical-stimulation-of-the-spinal-accessory-nerve-best-spin-for-prevention-of-shoulder-dysfunction-after-oncologic-neck-dissection-a-double-blinded-randomized-controlled-trial
#16
Brittany Barber, Hadi Seikaly, K Ming Chan, Rhys Beaudry, Shannon Rychlik, Jaret Olson, Matthew Curran, Peter Dziegielewski, Vincent Biron, Jeffrey Harris, Margaret McNeely, Daniel O'Connell
BACKGROUND: Shoulder dysfunction is common after neck dissection for head and neck cancer (HNC). Brief electrical stimulation (BES) is a novel technique that has been shown to enhance neuronal regeneration after nerve injury by modulating the brain-derived neurotrophic growth factor (BDNF) pathways. The objective of this study was to evaluate the effect of BES on postoperative shoulder function following oncologic neck dissection. METHODS: Adult participants with a new diagnosis of HNC undergoing Level IIb +/- V neck dissection were recruited...
January 23, 2018: Journal of Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/29361498/respiromics-an-integrative-analysis-linking-mitochondrial-bioenergetics-to-molecular-signatures
#17
Ellen Walheim, Jacek R Wiśniewski, Martin Jastroch
OBJECTIVE: Energy metabolism is challenged upon nutrient stress, eventually leading to a variety of metabolic diseases that represent a major global health burden. METHODS: Here, we combine quantitative mitochondrial respirometry (Seahorse technology) and proteomics (LC-MS/MS-based total protein approach) to understand how molecular changes translate to changes in mitochondrial energy transduction during diet-induced obesity (DIO) in the liver. RESULTS: The integrative analysis reveals that significantly increased palmitoyl-carnitine respiration is supported by an array of proteins enriching lipid metabolism pathways...
January 5, 2018: Molecular Metabolism
https://www.readbyqxmd.com/read/29327439/the-hidden-concealed-left-sided-accessory-pathway-an-uncommon-cause-of-svt-in-young-people
#18
Robert H Pass, Leonardo Liberman, Eric S Silver, Christopher M Janson, Andrew D Blaufox, Lynn Nappo, Scott R Ceresnak
BACKGROUND: Concealed left sided accessory pathways (CLAP) are a cause of SVT in the young. Most are mapped with RV apical/outflow pacing. Rarely, alternative means of mapping are required. We review our experience from 3 pediatric EP centers with a rare form of "hidden" CLAP. METHODS: All patients < 21 years undergoing EP study from 2008-2014 with a "hidden" CLAP (defined as an accessory pathway (AP) for which RV pacing at CL's stable for mapping did not demonstrate eccentric retrograde conduction) were included...
January 12, 2018: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/29315757/unexpected-effect-of-mad-honey-poisoning-on-accessory-pathway
#19
Adem Atici, Samim Emet, Ahmet Kaya Bilge, Kamil Adalet
No abstract text is available yet for this article.
January 8, 2018: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/29315367/sudden-death-in-patients-with-ebstein-anomaly
#20
Christine H Attenhofer Jost, Nicholas Y Tan, Abdalla Hassan, Emily R Vargas, David O Hodge, Joseph A Dearani, Heidi Connolly, Samuel J Asirvatham, Christopher J McLeod
Aims: Ventricular dysfunction or structural alteration of either ventricle is a well-established risk factor for sudden death (SD). Ebstein anomaly (EA) can present with both right and left heart abnormalities; however, predictors of SD have not been described. We therefore sought to characterize the incidence and risk factors of SD among a large cohort of patients with EA. Methods and results: All EA patients who underwent evaluation at a high-volume institution over a 4-decade period were retrospectively reviewed...
January 5, 2018: European Heart Journal
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