keyword
MENU ▼
Read by QxMD icon Read
search

Accessory pathway

keyword
https://www.readbyqxmd.com/read/28201731/radiofrequency-catheter-ablation-of-left-sided-accessory-pathways-in-children-using-a-new-fluoroscopy-integrated-3d-mapping-system
#1
Fabrizio Drago, Gino Grifoni, Romolo Remoli, Mario Salvatore Russo, Daniela Righi, Vincenzo Pazzano, Rosalinda Palmieri, Silvia Placidi, Fabio Anselmo Saputo, Massimo Stefano Silvetti
No abstract text is available yet for this article.
February 15, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28148821/the-notch-pathway-in-the-annelid-platynereis-insights-into-chaetogenesis-and-neurogenesis-processes
#2
Eve Gazave, Quentin I B Lemaître, Guillaume Balavoine
Notch is a key signalling pathway playing multiple and varied functions during development. Notch regulates the selection of cells with a neurogenic fate and maintains a pool of yet uncommitted precursors through lateral inhibition, both in insects and in vertebrates. Here, we explore the functions of Notch in the annelid Platynereis dumerilii (Lophotrochozoa). Conserved components of the pathway are identified and a scenario for their evolution in metazoans is proposed. Unexpectedly, neither Notch nor its ligands are expressed in the neurogenic epithelia of the larva at the time when massive neurogenesis begins...
February 2017: Open Biology
https://www.readbyqxmd.com/read/28133776/non-homologous-end-joining-common-interaction-sites-and-exchange-of-multiple-factors-in-the-dna-repair-process
#3
Stuart L Rulten, Gabrielle J Grundy
Non-homologous end-joining (NHEJ) is the dominant means of repairing chromosomal DNA double strand breaks (DSBs), and is essential in human cells. Fifteen or more proteins can be involved in the detection, signalling, synapsis, end-processing and ligation events required to repair a DSB, and must be assembled in the confined space around the DNA ends. We review here a number of interaction points between the core NHEJ components (Ku70, Ku80, DNA-PKcs, XRCC4 and Ligase IV) and accessory factors such as kinases, phosphatases, polymerases and structural proteins...
January 30, 2017: BioEssays: News and Reviews in Molecular, Cellular and Developmental Biology
https://www.readbyqxmd.com/read/28129887/a-left-lateral-accessory-pathway-unmasked-by-rivastigmine
#4
Charles Guenancia, Marie Fichot, Fabien Garnier, Mathieu Montoy, Gabriel Laurent
A 75-year-old woman was referred for advice regarding surface electrocardiographic modifications after the initiation of rivastigmine. In our patient, the baseline ECGs appeared perfectly normal. However, the initiation of a cholinesterase inhibitor unmasked a left lateral accessory pathway that had never been diagnosed before. Although cholinesterase inhibitors are known to increase vagal tone, the PR interval was shortened after rivastigmine administration, thus excluding this hypothesis to explain the appearance of the accessory pathway...
January 16, 2017: Journal of Electrocardiology
https://www.readbyqxmd.com/read/28115015/early-changes-in-gene-expression-and-inflammatory-proteins-in-systemic-juvenile-idiopathic-arthritis-patients-on-canakinumab-therapy
#5
Arndt H Brachat, Alexei A Grom, Nico Wulffraat, Hermine I Brunner, Pierre Quartier, Riva Brik, Liza McCann, Huri Ozdogan, Lidia Rutkowska-Sak, Rayfel Schneider, Valeria Gerloni, Liora Harel, Maria Terreri, Kristin Houghton, Rik Joos, Daniel Kingsbury, Jorge M Lopez-Benitez, Stephan Bek, Martin Schumacher, Marie-Anne Valentin, Hermann Gram, Ken Abrams, Alberto Martini, Daniel J Lovell, Nanguneri R Nirmala, Nicolino Ruperto
BACKGROUND: Canakinumab is a human anti-interleukin-1β (IL-1β) monoclonal antibody neutralizing IL-1β-mediated pathways. We sought to characterize the molecular response to canakinumab and evaluate potential markers of response using samples from two pivotal trials in systemic juvenile idiopathic arthritis (SJIA). METHODS: Gene expression was measured in patients with febrile SJIA and in matched healthy controls by Affymetrix DNA microarrays. Transcriptional response was assessed by gene expression changes from baseline to day 3 using adapted JIA American College of Rheumatology (aACR) response criteria (50 aACR JIA)...
January 23, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28114851/theoretical-and-experimental-analysis-of-amplitude-control-ablation-and-bipolar-ablation-in-creating-linear-lesion-and-discrete-lesions-for-treating-atrial-fibrillation
#6
Shengjie Yan, Xiaomei Wu, Weiqi Wang
PURPOSE: Radiofrequency (RF) energy is often used to create a linear lesion or discrete lesions for blocking the accessory conduction pathways for treating atrial fibrillation. By using finite element analysis, we study the ablation effect of amplitude control ablation mode (AcM) and bipolar ablation mode (BiM) in creating a linear lesion and discrete lesions in a 5-mm-thick atrial wall; particularly, the characteristic of lesion shape has been investigated in amplitude control ablation...
January 23, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28110427/evaluation-of-inos-icam-1-and-vcam-1-gene-expression-a-study-of-adult-t-cell-leukemia-malignancy-associated-with-htlv-1
#7
Mahdokht Jafarian, Sayed-Hamidreza Mozhgani, Elham Patrad, Hamidreza Vaziri, Seyed Abdolrahim Rezaee, Mohammad Mehdi Aakbarin, Mehdi Norouzi
The main aim of this study was to evaluate the expression of intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), and inducible nitric oxide synthase (iNOS) as host factors, and proviral load as the viral parameter, in adult T-cell leukemia/lymphoma (ATLL) individuals and healthy carrier (HC(s)) groups. Peripheral blood mononuclear cells (PBMC) from ATLL patients (n = 17) and HC subjects (as the control group, n = 17) were evaluated using real-time PCR to determine the levels of HTLV-1 proviral load and mRNA expression of ICAM, VCAM-1, and iNOS...
January 21, 2017: Archives of Virology
https://www.readbyqxmd.com/read/28109316/adenosine-induced-ventricular-fibrillation-in-a-structurally-normal-heart-a-case-report
#8
Christopher A Rajkumar, Norman Qureshi, Fu Siong Ng, Vasileios F Panoulas, Phang Boon Lim
BACKGROUND: Adenosine is the first-line pharmacotherapy for termination of supraventricular tachycardia through its action on the atrioventricular node. However, pro-arrhythmic effects of adenosine are also recognised, most notably in the presence of pre-excited atrial fibrillation. In this case report, we describe the induction of ventricular fibrillation in a patient with no demonstrable accessory pathway, nor any other structural heart disease. This rare, idiosyncratic reaction has never previously been reported and is of relevance given the widespread and routine use of adenosine in clinical practice...
January 22, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28106025/aneurysm-of-the-muscular-septum-associated-with-wolf-parkinson-white-syndrome-presenting-as-dilated-cardiomyopathy-a-report-of-two-cases
#9
Vehbi Doğan, İlker Ertuğrul, Şeyma Kayalı, Utku Arman Örün, Selmin Karademir
Muscular septal aneurysms are extremely rare without a ventricular septal defect and are diagnosed accidentally in most cases. Reported cases generally have rhythm disturbance or electrocardiographic findings of Wolf-Parkinson-White (WPW) syndrome. Presently described are 2 cases of ventricular septal aneurysm associated with WPW syndrome, which presented as dilated cardiomyopathy. Pre-excitation disappeared gradually in first patient. There was also concurrent decrease in degree of bulging of the interventricular septum and improvement of left ventricular systolic function...
January 2017: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
https://www.readbyqxmd.com/read/28101960/effects-of-antegrade-accessory-pathway-conduction-on-qrs-terminal-vector-in-patients-with-preexcitation-syndrome
#10
Renguang Liu, Q I Chen, Yang Chen, Yingjie Zhang, Zhaolong Xu, Gaopin Wang
BACKGROUND: Ventricle preexcitation through accessory pathway changes QRS initial vector, and manifests as delta wave on electrocardiogram (ECG). However, QRS terminal vector can also be affected. METHODS: A total of 158 patients who had single accessory pathway (AP) with antegrade conduction capacity were included and divided into two groups according to the ECG with or without delta wave. Note that 150 patients had delta wave (overt AP group) on ECG; classical preexcitation syndrome was diagnosed before radiofrequency ablation...
January 19, 2017: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/28098354/concealed-accessory-pathways-with-a-single-ventricular-and-two-discrete-atrial-insertion-sites
#11
Ryan T Kipp, Raed Abu Sham'a, Ito Hiroyuki, Frederick T Han, Marwan Refaat, Jonathan C Hsu, Michael E Field, Douglas E Kopp, Gregory M Marcus, Melvin M Scheinman, Kurt S Hoffmayer
BACKGROUND: Atrioventricular reciprocating tachycardia utilizing a concealed accessory pathway is common. It is well appreciated that some patients may have multiple accessory pathways with separate atrial and ventricular insertion sites. METHODS: We present three cases of AVRT utilizing concealed pathways with evidence that each utilizing a single ventricular insertion and two discrete atrial insertion sites. RESULTS: In case one, two discrete atrial insertion sites were mapped in two separate procedures, and only during the second ablation was the Kent potential identified...
January 18, 2017: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/28096448/loss-of-function-mutations-in-hspr-rescue-the-growth-defect-of-a-mycobacterium-tuberculosis-proteasome-activator-e-pafe-mutant
#12
Jordan B Jastrab, Marie I Samanovic, Richard Copin, Bo Shopsin, K Heran Darwin
: Mycobacterium tuberculosis uses a proteasome to degrade proteins by both ATP-dependent and -independent pathways. While much has been learned about ATP-dependent degradation, relatively little is understood about the ATP-independent pathway, which is controlled by Mycobacterium tuberculosis proteasome accessory factor E (PafE). Recently, we found that a Mycobacterium tuberculosis pafE mutant has slowed growth in vitro and is sensitive to killing by heat stress. However, we did not know if these phenotypes were caused by an inability to degrade the PafE-proteasome substrate HspR (heat shock protein repressor), an inability to degrade any damaged or misfolded proteins, or a defect in another protein quality control pathway...
January 17, 2017: Journal of Bacteriology
https://www.readbyqxmd.com/read/28088165/genomic-characterization-of-ensifer-aridi-a-proposed-new-species-of-nitrogen-fixing-rhizobium-recovered-from-asian-african-and-american-deserts
#13
Antoine Le Quéré, Nisha Tak, Hukam Singh Gehlot, Celine Lavire, Thibault Meyer, David Chapulliot, Sonam Rathi, Ilham Sakrouhi, Guadalupe Rocha, Marine Rohmer, Dany Severac, Abdelkarim Filali-Maltouf, Jose-Antonio Munive
BACKGROUND: Nitrogen fixing bacteria isolated from hot arid areas in Asia, Africa and America but from diverse leguminous plants have been recently identified as belonging to a possible new species of Ensifer (Sinorhizobium). In this study, 6 strains belonging to this new clade were compared with Ensifer species at the genome-wide level. Their capacities to utilize various carbon sources and to establish a symbiotic interaction with several leguminous plants were examined. RESULTS: Draft genomes of selected strains isolated from Morocco (Merzouga desert), Mexico (Baja California) as well as from India (Thar desert) were produced...
January 14, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28062807/junctional-adhesion-molecule-a-expression-in-the-murine-epididymal-tract-and-accessory-organs-and-acquisition-by-maturing-sperm
#14
Kathie Z Wu, Kun Li, Deni S Galileo, Patricia A Martin-DeLeon
STUDY QUESTION: Is junctional adhesion molecule A (JAM-A), a sperm protein essential for normal motility, expressed in the murine post-testicular pathway and involved in sperm maturation? SUMMARY ANSWER: JAM-A is present in the prostate and seminal vesicles and in all three regions of the epididymis where it is secreted in epididymosomes in the luminal fluid and can be delivered to sperm in vitro. WHAT IS KNOWN ALREADY: JAM-A shares with the plasma membrane Ca(2+)ATPase 4 (PMCA4, the major Ca(2+) efflux pump in murine sperm) a common interacting partner, CASK (Ca(2+)/CaM-dependent serine kinase)...
January 6, 2017: Molecular Human Reproduction
https://www.readbyqxmd.com/read/28043355/proposal-of-a-new-model-for-cl-regression-or-maintenance-during-pregnancy-on-the-basis-of-timing-of-regression-of-contralateral-accessory-cl-in-pregnant-cows
#15
Giovanni M Baez, Eduardo Trevisol, Rafael V Barletta, Beatriz O Cardoso, Alessandro Ricci, Jerry N Guenther, Nicole E Cummings, Milo C Wiltbank
In bovine pregnancy, regression or maintenance of the corpus luteum (CL) is mediated through local communication pathways between embryo, uterus, and ovary with Days 16 to 25 of pregnancy generally recognized as the pivotal period determining either luteolysis or prevention of luteolysis. To evaluate this concept, accessory CL was generated by treating Holstein lactating dairy cows (n = 718) with GnRH on Day 5 of the first follicular wave to produce an accessory CL on the ovary either contralateral or ipsilateral to the gravid horn...
February 2017: Theriogenology
https://www.readbyqxmd.com/read/28031278/vfrb-is-a-key-activator-of-the-staphylococcus-aureus-saers-two-component-system
#16
Christina N Krute, Kelly C Rice, Jeffrey L Bose
In previous studies, we identified the fatty acid kinase virulence factor regulator B (VfrB) as a potent regulator of α-hemolysin and other virulence factors in Staphylococcus aureus In this study, we demonstrated that VfrB is a positive activator of the SaeRS two-component regulatory system. Analysis of vfrB, saeR, and saeS mutant strains revealed that VfrB functions in the same pathway as SaeRS. At the transcriptional level, the promoter activities of SaeRS class I (coa) and class II (hla) target genes were downregulated during the exponential growth phase in the vfrB mutant, compared to the wild-type strain...
March 1, 2017: Journal of Bacteriology
https://www.readbyqxmd.com/read/28011105/a-guide-to-transseptal-access
#17
Enes E Gul, Adrian Baranchuk, Benedict M Glover
Transseptal access is commonly performed for any procedure that requires access to the left side of the heart such as catheter ablation of atrial fibrillation, left atrial tachycardia, left-sided accessory pathways, ventricular tachycardia, left atrial appendage closure, percutaneous mitral valvuloplasty, and mitral valve repair. To perform this in a safe and effective manner it is important that the operator has a detailed knowledge of the relevant anatomy, the technique required, and the ability to deal with difficult cases and complications...
October 21, 2016: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/28009280/three-dimensional-architecture-of-the-human-brca1-a-histone-deubiquitinase-core-complex
#18
Otto J P Kyrieleis, Pauline B McIntosh, Sarah R Webb, Lesley J Calder, Janette Lloyd, Nisha A Patel, Stephen R Martin, Carol V Robinson, Peter B Rosenthal, Stephen J Smerdon
BRCA1 is a tumor suppressor found to be mutated in hereditary breast and ovarian cancer and plays key roles in the maintenance of genomic stability by homologous recombination repair. It is recruited to damaged chromatin as a component of the BRCA1-A deubiquitinase, which cleaves K63-linked ubiquitin chains attached to histone H2A and H2AX. BRCA1-A contributes to checkpoint regulation, repair pathway choice, and HR repair efficiency through molecular mechanisms that remain largely obscure. The structure of an active core complex comprising two Abraxas/BRCC36/BRCC45/MERIT40 tetramers determined by negative-stain electron microscopy (EM) reveals a distorted V-shape architecture in which a dimer of Abraxas/BRCC36 heterodimers sits at the base, with BRCC45/Merit40 pairs occupying each arm...
December 20, 2016: Cell Reports
https://www.readbyqxmd.com/read/28003490/lineage-a-betacoronavirus-ns2-proteins-and-the-homologous-torovirus-berne-pp1a-carboxy-terminal-domain-are-phosphodiesterases-that-antagonize-activation-of-rnase-l
#19
Stephen A Goldstein, Joshua M Thornbrough, Rong Zhang, Babal K Jha, Yize Li, Ruth Elliott, Katherine Quiroz-Figueroa, Annie I Chen, Robert H Silverman, Susan R Weiss
Viruses in the family Coronaviridae, within the order Nidovirales, are etiologic agents of a range of human and animal diseases, including both mild and severe respiratory diseases in humans. These viruses encode conserved replicase and structural proteins as well as more diverse accessory proteins, encoded in the 3' ends of their genomes, that often act as host cell antagonists. We previously showed that 2',5'-phosphodiesterases (2',5'-PDEs) encoded by the prototypical Betacoronavirus, mouse hepatitis virus (MHV), and by Middle East respiratory syndrome-associated coronavirus antagonize the oligoadenylate-RNase L (OAS-RNase L) pathway...
March 1, 2017: Journal of Virology
https://www.readbyqxmd.com/read/27994506/distributed-features-of-vimentin-containing-neural-precursor-cells-in-olfactory-bulb-of-sod1g93a-transgenic-mice-a-study-about-resource-of-endogenous-neural-stem-cells
#20
Chunyan Tang, Lei Zhu, Weiming Gan, Huiting Liang, Jiao Li, Jie Zhang, Xiong Zhang, Yi Lu, Renshi Xu
No any effective treatments can prevent from the motor neuron degeneration in amyotrophic lateral sclerosis (ALS) at present. In order to modulating the endogenous neural precursor cells (NPCs) to repairing the degenerative motor neurons in ALS, we studied the alteration of endogenous vimentin-containing NPCs in olfactory bulb (OB) at the different stages of SOD1 wlid-type and G93A transgenic mice. The results showed that the vimentin-containing cells (VCCs) were mainly distributed in the glomerular layer (Gl), the accessory OB (AOB), the OB core, the granular cell layer (GRO) and the mitral cell layer (MI)+the internal plexiform layer (IPL) of the OB of adult mice...
2016: International Journal of Biological Sciences
keyword
keyword
18849
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"