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Acute pancreatic injury

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https://www.readbyqxmd.com/read/27895424/irf5-regulates-lung-macrophages-m2-polarization-during-severe-acute-pancreatitis-in-vitro
#1
Kang Sun, Song-Bing He, Jian-Guo Qu, Sheng-Chun Dang, Ji-Xiang Chen, Ai-Hua Gong, Rong Xie, Jian-Xin Zhang
AIM: To investigate the role of interferon regulatory factor 5 (IRF5) in reversing polarization of lung macrophages during severe acute pancreatitis (SAP) in vitro. METHODS: A mouse SAP model was established by intraperitoneal (ip) injections of 20 μg/kg body weight caerulein. Pathological changes in the lung were observed by hematoxylin and eosin staining. Lung macrophages were isolated from bronchoalveolar lavage fluid. The quantity and purity of lung macrophages were detected by fluorescence-activated cell sorting and evaluated by real-time polymerase chain reaction (RT-PCR)...
November 14, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27878246/luteolin-protects-mice-from-severe-acute-pancreatitis-by-exerting-ho-1-mediated-anti-inflammatory-and-antioxidant-effects
#2
Jie Xiong, Kezhou Wang, Chunxiao Yuan, Rong Xing, Jianbo Ni, Guoyong Hu, Fengling Chen, Xingpeng Wang
Reseda odorata L. has long been used in traditional Asian medicine for the treatment of diseases associated with oxidative injury and acute inflammation, such as endotoxemia, acute lung injury, acute myocardial infarction and hepatitis. Luteolin, the main component of Reseda odorata L., which is also widely found in many natural herbs and vege-tables, has been shown to induce heme oxygenase-1 (HO-1) expression to exert anti-inflammatory and antioxidant effects. In this study, we aimed to examine the effects of luteolin on mice with severe acute pancreatitis (SAP), and to explore the underlying mechanisms...
November 22, 2016: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/27866884/microrna-biomarkers-of-pancreatic-injury-in-a-canine-model
#3
Rodney Rouse, Barry Rosenzweig, Katie Shea, Alan Knapton, Sharron Stewart, Lin Xu, Ashok Chockalingam, Leah Zadrozny, Karol Thompson
Pancreas-enriched microRNAs have been experimentally investigated in rodents as candidate serum biomarkers of pancreatic injury with several different acute pancreatic injury models. In the present study, temporal and magnitude responses of exocrine pancreas-enriched miR-216a, miR-216b, and miR-217 and endocrine-enriched miR-375 and miR-148a were measured by droplet digital PCR in serum in a caerulein model of pancreatic injury in the dog. All 5 microRNAs followed a similar time course that mirrored the responses of the conventional serum pancreatic injury biomarkers, amylase and lipase...
November 17, 2016: Experimental and Toxicologic Pathology: Official Journal of the Gesellschaft Für Toxikologische Pathologie
https://www.readbyqxmd.com/read/27848953/immunopathogenesis-of-pancreatitis
#4
REVIEW
T Watanabe, M Kudo, W Strober
The conventional view of the pathogenesis of acute and chronic pancreatitis is that it is due to a genetic- or environment-based abnormality of intracellular acinar trypsinogen activation and thus to the induction of acinar cell injury that, in turn, sets in motion an intra-pancreatic inflammatory process. More recent studies, reviewed here, present strong evidence that while such trypsinogen activation is likely a necessary first step in the inflammatory cascade underlying pancreatitis, sustained pancreatic inflammation is dependent on damage-associated molecular patterns-mediated cytokine activation causing the translocation of commensal (gut) organisms into the circulation and their induction of innate immune responses in acinar cells...
November 16, 2016: Mucosal Immunology
https://www.readbyqxmd.com/read/27847836/obstructive-acute-pancreatitis-secondary-to-peg-tube-migration
#5
Douglas F Taylor, Ryan Cho, Allan Cho, Viet Nguyen, Abhijit Sunnapwar, Craig Womeldorph
Percutaneous gastrostomy is a well-established method of providing enteral nutrition to patients incapable of oral intake, or for whom oral intake is insufficient to meet metabolic needs. In comparison to total parenteral nutrition, enteral feeding is advantageous in that it helps maintain gut mucosal integrity, which decreases the risk of bacterial translocation through the gastrointestinal tract. Complications include bleeding, aspiration, internal organ injury, perforation, periostomal leaks, tube dislodgement, and occlusion...
August 2016: ACG Case Reports Journal
https://www.readbyqxmd.com/read/27847555/sulforaphane-protects-pancreatic-acinar-cell-injury-by-modulating-nrf2-mediated-oxidative-stress-and-nlrp3-inflammatory-pathway
#6
Zhaojun Dong, Haixiao Shang, Yong Q Chen, Li-Long Pan, Madhav Bhatia, Jia Sun
Acute pancreatitis (AP) is characterized by early activation of intra-acinar proteases followed by acinar cell death and inflammation. Cellular oxidative stress is a key mechanism underlying these pathological events. Sulforaphane (SFN) is a natural organosulfur antioxidant with undescribed effects on AP. Here we investigated modulatory effects of SFN on cellular oxidation and inflammation in AP. AP was induced by cerulean hyperstimulation in BALB/c mice. Treatment group received a single dose of 5 mg/kg SFN for 3 consecutive days before AP...
2016: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/27846860/purtscher-s-retinopathy-and-renal-cortical-necrosis-two-rare-vaso-occlusive-complications-in-a-patient-with-acute-pancreatitis-a-case-report
#7
Wasim Md Mohosin Ul Haque, Mehruba Alam Ananna, Hasna Fahmima Haque, Muhammad Abdur Rahim, Tabassum Samad, Sarwar Iqbal
BACKGROUND: Purtscher's retinopathy and renal cortical necrosis are two rare vaso-occlusive complications of acute pancreatitis. Purtscher's retinopathy causes sudden impairment of vision, which was first reported in a patient with head trauma. Subsequently, it was also reported as a complication of acute pancreatitis and few other clinical conditions. Acute pancreatitis also rarely causes renal cortical necrosis leading to acute kidney injury. However, the simultaneous presence of both complications is rarely reported...
November 15, 2016: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/27832059/elevated-serum-fibroblast-growth-factor-21-in-humans-with-acute-pancreatitis
#8
Vivek K Shenoy, Kristin M Beaver, Ffolliott M Fisher, Garima Singhal, Jody R Dushay, Eleftheria Maratos-Flier, Sarah N Flier
BACKGROUND: The metabolic regulator Fibroblast Growth Factor 21 (FGF21) is highly expressed in the acinar pancreas, but its role in pancreatic function is obscure. It appears to play a protective role in acute experimental pancreatitis in mice. The aim of this study was to define an association between FGF21 and the course and resolution of acute pancreatitis in humans. METHODS AND PRINCIPAL FINDINGS: Twenty five subjects with acute pancreatitis admitted from May to September 2012 to the Beth Israel Deaconess Medical Center (BIDMC) were analyzed...
2016: PloS One
https://www.readbyqxmd.com/read/27830885/the-protective-role-of-melatonin-on-l-arginine-induced-acute-pancreatitis-in-adult-male-albino-rats
#9
Ahmed S Sadek, Rehab T Khattab
BACKGROUND: Acute pancreatitis (AP) is an inflammatory disease that has an increasing incidence worldwide. It is associated with high morbidity and mortality rates ranging from 15-40% in its severe form. Oxidative stress plays an important role in pancreatic acinar cell injury in case of AP. Melatonin is proven to have both antioxidant and anti-inflammatory effects. The aim of the work was to investigate the protective role of melatonin (Mel) against L-arginine (L-arg)-induced AP in adult male albino rats...
November 10, 2016: Folia Morphologica (Warsz)
https://www.readbyqxmd.com/read/27822039/carbon-monoxide-bound-hemoglobin-vesicles-ameliorate-multiorgan-injuries-induced-by-severe-acute-pancreatitis-in-mice-by-their-anti-inflammatory-and-antioxidant-properties
#10
Saori Nagao, Kazuaki Taguchi, Hiromi Sakai, Keishi Yamasaki, Hiroshi Watanabe, Masaki Otagiri, Toru Maruyama
Carbon monoxide (CO) has attracted attention as a possible therapeutic agent for affecting anti-inflammatory and antioxidant activities. Previously, CO-bound hemoglobin vesicle (CO-HbV) was developed as a nanotechnology-based CO donor, and its safety profile and therapeutic potential as a clinically applicable carrier of CO were examined in vitro and in vivo. In the present study, the therapeutic efficacy of CO-HbV against severe acute pancreatitis was examined with secondary distal organ-injured model mice that were fed with a choline-deficient ethionine-supplemented diet...
2016: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/27821124/severe-leptospirosis-and-pancreatitis-a-case-series-from-a-leptospirosis-outbreak-in-anuradhapura-district-sri-lanka
#11
N J Herath, C J Kamburapola, S B Agampodi
BACKGROUND: Acute pancreatitis is identified as an atypical and rare presentation of leptospirosis. In this report, we discuss a case series of severe leptospirosis with pancreatitis as a main complication during an unusual outbreak of leptospirosis in Anuradhapura district, Sri Lanka. CASE PRESENTATION: We retrospectively reviewed clinical presentation, investigations, treatment and outcome of six confirmed cases of severe leptospirosis admitted to intensive care unit (ICU) of Teaching Hospital, Anuradhapura, within a three months period from November 2014 to January 2015...
November 7, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27798670/prospective-multicentre-nationwide-clinical-data-from-600-cases-of-acute-pancreatitis
#12
Andrea Párniczky, Balázs Kui, Andrea Szentesi, Anita Balázs, Ákos Szűcs, Dóra Mosztbacher, József Czimmer, Patrícia Sarlós, Judit Bajor, Szilárd Gódi, Áron Vincze, Anita Illés, Imre Szabó, Gabriella Pár, Tamás Takács, László Czakó, Zoltán Szepes, Zoltán Rakonczay, Ferenc Izbéki, Judit Gervain, Adrienn Halász, János Novák, Stefan Crai, István Hritz, Csaba Góg, János Sümegi, Petra Golovics, Márta Varga, Barnabás Bod, József Hamvas, Mónika Varga-Müller, Zsuzsanna Papp, Miklós Sahin-Tóth, Péter Hegyi
OBJECTIVE: The aim of this study was to analyse the clinical characteristics of acute pancreatitis (AP) in a prospectively collected, large, multicentre cohort and to validate the major recommendations in the IAP/APA evidence-based guidelines for the management of AP. DESIGN: Eighty-six different clinical parameters were collected using an electronic clinical research form designed by the Hungarian Pancreatic Study Group. PATIENTS: 600 adult patients diagnosed with AP were prospectively enrolled from 17 Hungarian centres over a two-year period from 1 January 2013...
2016: PloS One
https://www.readbyqxmd.com/read/27798657/the-met-receptor-tyrosine-kinase-confers-repair-of-murine-pancreatic-acinar-cells-following-acute-and-chronic-injury
#13
Ivana Gaziova, Daniel Jackson, Paul J Boor, Dwayne Carter, Zobeida Cruz-Monserrate, Cornelis J Elferink, Aditya D Joshi, Bhupendra Kaphalia, Craig D Logsdon, Karen Pereira de Castro, Lynn Soong, Xinrong Tao, Suimin Qiu, Lisa A Elferink
Acinar cells represent the primary target in necroinflammatory diseases of the pancreas, including pancreatitis. The signaling pathways guiding acinar cell repair and regeneration following injury remain poorly understood. The purpose of this study was to determine the importance of Hepatocyte Growth Factor Receptor/MET signaling as an intrinsic repair mechanism for acinar cells following acute damage and chronic alcohol-associated injury. Here, we generated mice with targeted deletion of MET in adult acinar cells (MET-/-)...
2016: PloS One
https://www.readbyqxmd.com/read/27796938/plasma-hydrogen-sulphide-does-not-predict-severity-of-acute-pancreatitis-in-humans
#14
Iqbal N Qureshi, Deepu David, Kavitha R Thangaraj, Reuben T Kurien, Sudipta D Chowdhury, Ashish Goel, Amit K Dutta, Ebby G Simon, Anup Ramachandran, Kunissery A Balasubramanian, Anjilivelil J Joseph
The primary aim of this study was to assess the usefulness of plasma hydrogen sulphide (H2S) level at admission as a predictor of severity of acute pancreatitis. The secondary aims were to examine whether the level of H2S after 48 h correlated with severity and whether level of H2S correlated with pulmonary, renal or infectious complications. Plasma hydrogen sulphide was measured within 24 h of admission and 48 h later, in patients with acute pancreatitis. Patients were classified as having mild or severe pancreatitis, and H2S levels in the two groups were compared...
October 29, 2016: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
https://www.readbyqxmd.com/read/27779235/one-compound-of-saponins-from-disocorea-zingiberensis-protected-against-experimental-acute-pancreatitis-by-preventing-mitochondria-mediated-necrosis
#15
Rui Zhang, Li Wen, Yan Shen, Na Shi, Zhihua Xing, Qing Xia, Hai Niu, Wen Huang
Acute pancreatitis (AP) is a painful inflammatory disorder of the exocrine pancreas, ranking as the most common gastrointestinal reasons for hospitalization with no specific therapy currently. Diosgenyl saponins extracted from natural products and diosgenin or its derivatives have been shown to exert anti-inflammatory effects in various diseases. However, the therapeutic effects of diosgenyl saponins from Dioscorea zingiberensis C. H. Wright in AP have not yet been determined. Five compounds were extracted and screened for taurocholate-induced necrosis in mouse pancreatic acinar cells...
October 25, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27776048/role-of-microvesicles-from-bone-marrow-mesenchymal-stem-cells-in-acute-pancreatitis
#16
Guojian Yin, Guoyong Hu, Rong Wan, Ge Yu, Xiaofeng Cang, Jie Xiong, Jianbo Ni, Yanling Hu, Miao Xing, Yuting Fan, Wenqin Xiao, Lei Qiu, Maochun Tang, Yan Zhao, Shaofeng Wang, Xingpeng Wang
OBJECTIVES: Mesenchymal stem cells (MSCs) have shown an obvious protective effect on acute pancreatitis (AP). The purpose of the present study was to analyze the effect of bone marrow MSC-derived microvesicles (bmMSC-MVs) on AP and explore the underlying mechanisms. METHODS: Bone marrow MSCs and bmMSC-MVs were isolated from Sprague-Dawley rats. Cerulein-induced mild AP (MAP) and sodium taurocholate-induced severe AP (SAP) were used as AP models in vivo and in vitro...
October 2016: Pancreas
https://www.readbyqxmd.com/read/27733144/successful-treatment-of-gemcitabine-induced-acute-interstitial-pneumonia-with-imatinib-mesylate-a-case-report
#17
Elisabetta Fenocchio, Ilaria Depetris, Delia Campanella, Lucia Garetto, Fabrizio Carnevale Schianca, Danilo Galizia, Giovanni Grignani, Massimo Aglietta, Francesco Leone
BACKGROUND: Gemcitabine is currently the standard chemotherapy for the adjuvant treatment of pancreatic cancer. This chemotherapeutic agent is generally well-tolerated, myelosuppression and gastrointestinal toxicity being common side effects. Nevertheless, gemcitabine-induced pulmonary toxicity has been rarely reported. Despite its low incidence, the spectrum of pulmonary injury is wide, including potentially fatal conditions. We report a case of acute interstitial pneumonia related to gemcitabine, completely solved with Imatinib Mesylate (IM)...
October 12, 2016: BMC Cancer
https://www.readbyqxmd.com/read/27716570/ectopic-pregnancy-in-simultaneous-pancreas-kidney-transplantation-a-case-report
#18
Shinji Yamamoto, Maria Nelander
INTRODUCTION: We present a case report of ectopic pregnancy (EP) after simultaneous pancreas-kidney transplantation (SKPTx). PRESENTATION OF CASE: A 33-year-old female status post SKPTx suddenly got abdominal pain in the lower level. She had high human chorionic Gonadotropin test. Ultrasonography revealed that there was no fetus in the uterus but a dilated right fallopian tube, which strongly suggested ectopic pregnancy. An emergency operation was performed and a dilated right side uterine tube was found with adhesions to her transplant...
2016: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/27677759/-therapeutic-plasma-exchange-for-the-treatment-of-hypertriglyceridemia-induced-pancreatitis-a-case-report
#19
G Eden, F Gradaus, K Brown, I Gauert, C Sass, J T Kielstein
A rare but serious form of pancreatitis is caused by severe hypertriglyceridemia. It accounts for up to 10 % of all acute pancreatitis episodes. Despite a pathophysiology that differs distinctly from other forms of pancreatitis, there are no accepted guidelines for the treatment of hypertriglyceridemia-induced pancreatitis. We report a morbidly obese (BMI 45 kg/m²) 36-year-old Caucasian woman with a history of schizophrenic psychosis who was transferred to our tertiary care hospital for further diagnosis and treatment of increasing abdominal pain and hypertryglyceridemia of 2757 mg/dl...
September 27, 2016: Medizinische Klinik, Intensivmedizin und Notfallmedizin
https://www.readbyqxmd.com/read/27663180/clinical-predictors-of-hospital-mortality-differ-between-direct-and-indirect-acute-respiratory-distress-syndrome
#20
Liang Luo, Ciara M Shaver, Zhiguo Zhao, Tatsuki Koyama, Carolyn S Calfee, Julie A Bastarache, Lorraine B Ware
BACKGROUND: Direct (pulmonary) and indirect (extrapulmonary) ARDS are distinct syndromes with important pathophysiologic differences. The goal of this study was to determine whether clinical characteristics and predictors of mortality differ between direct or indirect ARDS. METHODS: A retrospective observational cohort study of 417 ARDS patients. Each patient was classified as having direct (pneumonia or aspiration, n=250) or indirect ARDS (non-pulmonary sepsis or pancreatitis, n=167)...
September 20, 2016: Chest
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