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Acute pancreatic injury

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https://www.readbyqxmd.com/read/29151698/circulating-mirnas-as-biomarkers-for-severe-acute-pancreatitis-associated-with-acute-lung-injury
#1
Xiao-Guang Lu, Xin Kang, Li-Bin Zhan, Li-Min Kang, Zhi-Wei Fan, Li-Zhi Bai
AIM: To identify circulating micro (mi)RNAs as biological markers for prediction of severe acute pancreatitis (SAP) with acute lung injury (ALI). METHODS: Twenty-four serum samples were respectively collected and classified as SAP associated with ALI and SAP without ALI, and the miRNA expression profiles were determined by microarray analysis. These miRNAs were validated by quantitative reverse transcription-polymerase chain reaction, and their putative targets were predicted by the online software TargetScan, miRanda and PicTar database...
November 7, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29136086/intraoperative-oliguria-predicts-acute-kidney-injury-after-major-abdominal-surgery
#2
T Mizota, Y Yamamoto, M Hamada, S Matsukawa, S Shimizu, S Kai, Jonathan Thompson
Background: The threshold of intraoperative urine output below which the risk of acute kidney injury (AKI) increases is unclear. The aim of this retrospective cohort study was to investigate the relationship between intraoperative urine output during major abdominal surgery and the development of postoperative AKI and to identify an optimal threshold for predicting the differential risk of AKI. Methods: Perioperative data were collected retrospectively on 3560 patients undergoing major abdominal surgery (liver, colorectal, gastric, pancreatic, or oesophageal resection) at Kyoto University Hospital...
December 1, 2017: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/29135139/-laparoscopic-transperitoneal-adrenalectomy
#3
B G Guliev, B K Komyakov, D V Semenov
AIM: To analyze the results of laparoscopic adrenalectomy (LAE) in patients with adrenal gland tumors. MATERIALS AND METHODS: From 2011 to 2016, 24 patients (15 men, 9 women), mean age 49.6 +/- 8.2 years, underwent LAE. The right, left and bilateral LAE was performed in 12, 10 and 2 patients, respectively. Indications for surgery were mainly primary and metastatic adrenal tumors. The operations were performed using a transperitoneal 4-port approach. RESULTS: Twenty six LAE were successfully performed in 24 patients...
October 2017: Urologii︠a︡
https://www.readbyqxmd.com/read/29132523/pancreatitis-and-pancreatic-cancer
#4
REVIEW
Anne Walling, Robert Freelove
Most cases of acute pancreatitis are related to gallstones. More than 80% resolve within a few days. The diagnosis is based on upper abdominal pain, elevated lipase and/or amylase, and transabdominal ultrasound findings. Management requires early aggressive hydration, pain control, nutritional support, and monitoring for progression. Patients who develop hypovolemia, systemic inflammatory response, pancreatic necrosis, and organ failure have high mortality, risk of recurrence, and progression to chronic pancreatitis (CP)...
December 2017: Primary Care
https://www.readbyqxmd.com/read/29127325/acinar-injury-and-early-cytokine-response-in-human-acute-biliary-pancreatitis
#5
Aparna Jakkampudi, Ramaiah Jangala, Ratnakar Reddy, Sasikala Mitnala, G Venkat Rao, Rebala Pradeep, D Nageshwar Reddy, Rupjyoti Talukdar
Clinical acute pancreatitis (AP) is marked by an early phase of systemic inflammatory response syndrome (SIRS) with multiorgan dysfunction (MODS), and a late phase characterized by sepsis with MODS. However, the mechanisms of acinar injury in human AP and the associated systemic inflammation are not clearly understood. This study, for the first time, evaluated the early interactions of bile acid induced human pancreatic acinar injury and the resulting cytokine response. We exposed freshly procured resected human pancreata to taurolithocolic acid (TLCS) and evaluated for acinar injury, cytokine release and interaction with peripheral blood mononuclear cells (PBMCs)...
November 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29115652/early-laparoscopic-cholecystectomy-following-acute-biliary-pancreatitis-expedites-recovery
#6
Seracettin Eğin, Metin Yeşiltaş, Berk Gökçek, Hakan Tezer, Servet Rüştü Karahan
BACKGROUND: In this retrospective study, we aimed to assess the reliability of early cholecystectomy, risk of recurrent biliary pancreatitis, and their effects on hospital length of stay and morbidity by comparing the results of early and late laparoscopic cholecystectomy in patients with acute biliary pancreatitis. METHODS: A total of 131 patients, who were diagnosed with acute biliary pancreatitis at Okmeydanı Education and Research Hospital in January 2009-December 2012, were included in the study...
November 2017: Ulusal Travma Ve Acil Cerrahi Dergisi, Turkish Journal of Trauma & Emergency Surgery: TJTES
https://www.readbyqxmd.com/read/29102149/systemic-histone-release-disrupts-plasmalemma-and-contributes-to-necrosis-in-acute-pancreatitis
#7
Peter Szatmary, Tingting Liu, Simon T Abrams, Svetlana Voronina, Li Wen, Michael Chvanov, Wei Huang, Guozheng Wang, David N Criddle, Alexey V Tepikin, Cheng-Hock Toh, Robert Sutton
BACKGROUND: Clinical and experimental acute pancreatitis feature histone release within the pancreas from innate immune cells and acinar cell necrosis. In this study, we aimed to detail the source of circulating histones and assess their role in the pathogenesis of acute pancreatitis. METHODS: Circulating nucleosomes were measured in patient plasma, taken within 24 and 48 h of onset of acute pancreatitis and correlated with clinical outcomes. Using caerulein hyperstimulation, circulating histones were measured in portal, systemic venous and systemic arterial circulation in mice, and the effects of systemic administration of histones in this model were assessed...
October 7, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/29095150/spleen-preserving-distal-pancreatectomy-in-isolated-pancreatic-trauma
#8
Bora Barut, Felat Ciftci, Cuneyt Kayaalp
INTRODUCTION: Isolated pancreatic trauma is a rare condition and commonly come up in children or young adults.The poor initial symptoms lead to delay diagnosis and treatment. The treatment of isolated distal pancreatic trauma including the Wirsung's duct is generally distal pancreatectomy. In an emergency setting, splenectomy is a common additional organ resection requirement with the distal pancreatectomy. However, in circumstances, spleen preserving distal pancreatectomy can provide advantages in these age groups even in emergency conditions...
September 12, 2017: Annali Italiani di Chirurgia
https://www.readbyqxmd.com/read/29089686/acute-ischemic-pancreatitis-a-rare-complication-of-empirical-gastroduodenal-artery-embolization
#9
Wei Ming Chua, Nanda Venkatanarasimha, Karthikeyan Damodharan
Empirical embolization of the gastroduodenal artery (GDA) is accepted as a safe and effective treatment option for endoscopy-refractory nonvariceal upper gastrointestinal bleeding (UGIB) in patients with high surgical risk. Nontarget embolization is a recognized complication of transarterial embolization, however, symptomatic pancreatic injury is extremely rare. We report a patient who developed acute ischemic pancreatitis immediately after embolization of the GDA, which was confirmed intraoperatively. Interventionists as well as referring clinicians need to be aware of this rare but life threatening complication...
July 2017: Indian Journal of Radiology & Imaging
https://www.readbyqxmd.com/read/29083510/on-the-etiology-of-type-1-diabetes-physiological-growth-in-children-impacts-disease-progression
#10
REVIEW
Oskar Skog, Olle Korsgren
The prevailing view is that Type 1 Diabetes (T1D) develops as a consequence of a severe fall in beta-cell mass resulting from T-cell mediated autoimmunity. However, progression from islet autoantibody seroconversion to overt diabetes and finally to total loss of c-peptide production occurs in most affected subjects only slowly over many years or even decades. This slow disease progression should be viewed in relation to the total beta cell mass of only 0.2 - 1.5 g in non-diabetic adults. Focal lesions of acute pancreatitis with accumulation of leukocytes, often located around the ducts, are frequently observed in subjects with recent onset T1D and most patients display extensive periductal fibrosis, the end stage of inflammation...
October 30, 2017: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/29081601/resistin-as-a-prooxidant-factor-and-predictor-of-endothelium-damage-in-patients-with-mild-acute-pancreatitis-exposed-to-tobacco-smoke-xenobiotics
#11
Milena Ściskalska, Grzegorz Marek, Zygmunt Grzebieniak, Halina Milnerowicz
OBJECTIVES: The study was aimed to assess the influence of tobacco smoke exposure on the intensity of inflammation measured by IL-6, α1-antitripsin (AAT) and α1-acid glycoprotein (AGP) concentrations, and Cd level and oxidative stress intensity measured by advanced oxidation protein product (AOPP) concentration in the blood of healthy subjects and AP patients during hospitalization. Endothelin-1 (ET-1) and resistin concentrations, markers of endothelium injury, were determined. RESULTS: An increased IL-6 concentration in healthy smokers compared to nonsmokers and AP patients compared to controls was shown...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/29074451/mitochondrial-dysfunction-through-impaired-autophagy-leads-to-endoplasmic-reticulum-stress-deregulated-lipid-metabolism-and-pancreatitis-in-animal-models
#12
Gyorgy Biczo, Eszter T Vegh, Natalia Shalbueva, Olga A Mareninova, Jason Elperin, Ethan Lotshaw, Sophie Gretler, Aurelia Lugea, Sudarshan R Malla, David Dawson, Piotr Ruchala, Julian Whitelegge, Samuel W French, Li Wen, Sohail Z Husain, Fred S Gorelick, Peter Hegyi, Zoltan Rakonczay, Ilya Gukovsky, Anna S Gukovskaya
BACKGROUND & AIMS: Little is known about the signaling pathways that initiate and promote acute pancreatitis (AP). The pathogenesis of AP has been associated with abnormal increases in cytosolic Ca(2+), mitochondrial dysfunction, impaired autophagy, and endoplasmic reticulum (ER) stress. We analyzed the mechanisms of these dysfunctions and their relationships, and how these contribute to development of AP in mice and rats. METHODS: Pancreatitis was induced in C57BL/6J mice (control) and mice deficient in peptidylprolyl isomerase D (cyclophilin D, encoded by Ppid) by administration of L-arginine (also in rats), caerulein, bile acid, or an AP-inducing diet...
October 23, 2017: Gastroenterology
https://www.readbyqxmd.com/read/29057186/traumatic-pancreatitis-a-rare-complication-of-cardiopulmonary-resuscitation
#13
Muhammad Aziz
An elderly gentleman was successfully revived after undergoing cardiopulmonary resuscitation (CPR) for cardiac arrest. Post CPR, the patient developed acute pancreatitis which was likely complication of inappropriately delivered chest compressions which caused further complications and resulted in the death of the patient. This case underlines the importance of quality chest compressions that includes correct placement of hands by the operator giving chest compressions to avoid lethal injuries to the receiver...
August 17, 2017: Curēus
https://www.readbyqxmd.com/read/29054965/adenovirus-mediated-artificial-microrna-targeting-fibrinogen-like-protein-2-attenuates-the-severity-of-acute-pancreatitis-in-mice
#14
Xiaohua Ye, Jin Ding, Yanping Chen, Jiayue Dong
Severe acute pancreatitis (SAP) remains to be challenging for its unpredictable inflammatory progression from acute pancreatitis to SAP. Apoptosis is an important pathology of SAP. Fibrinogen-like protein 2 (FGL2) has been reported to be involved in apoptosis. The present study aimed to explore the therapeutic effect of an adenovirus-mediated artificial microRNA targeting FGL2 (Ad-FGL2-miRNA) in taurocholate-induced murine pancreatitis models. Sodium taurocholate was retrogradely injected into the biliopancreatic ducts of the C57/BL mice to induce SAP...
October 20, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/29042438/the-serum-protein-renalase-reduces-injury-in-experimental-pancreatitis
#15
Thomas R Kolodecik, Anamika M Reed, Kimie Date, Christine Shugrue, Vikhil Patel, Shang-Lin Chung, Gary V Desir, Fred S Gorelick
Acute pancreatitis is a disease associated with inflammation and tissue damage. One protein that protects against acute injury, including ischemic injury to both the kidney and heart, renalase, which is secreted into the blood by the kidney and other tissues. However, whether renalase reduces acute injury associated with pancreatitis is unknown. Here, we used both in vitro and in vivo murine models of acute pancreatitis to study renalase effects on this condition. In isolated pancreatic lobules, pretreatment with recombinant human renalase (rRNLS) blocked zymogen activation caused by cerulein, carbachol, and a bile acid...
October 17, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29040320/circulating-microrna-375-as-biomarker-of-pancreatic-beta-cell-death-and-protection-of-beta-cell-mass-by-cytoprotective-compounds
#16
Imane Song, Sarah Roels, Geert A Martens, Luc Bouwens
OBJECTIVE: Previous studies demonstrated that circulating microRNA-375 (miR-375) is a suitable plasma biomarker for real-time detection of beta cell death. The present study evaluated the use of this biomarker to assess the beta cytoprotective effect of phenylpropenoic acid glucoside (PPAG), which was previously demonstrated to protect beta cells against various types of injury, and of exendin-4, which is an established antidiabetic drug. METHODS: PPAG or exendin-4 were administered in mice treated with streptozotocin (STZ) to acutely induce beta cell death...
2017: PloS One
https://www.readbyqxmd.com/read/29033186/a-preliminary-study-on-fetal-lung-injury-in-a-rat-model-of-acute-pancreatitis-in-pregnancy
#17
Liang Zhao, Teng Zuo, Qiao Shi, Fang-Chao Mei, Yu-Pu Hong, Wen-Hong Deng, Jia Yu, Peng Hu, Wei-Xing Wang
Acute pancreatitis in pregnancy (APIP), which was thought to be rare, is becoming more frequent. In addition, high perinatal mortality among fetuses has been reported. Our research aimed to investigate and assess fetal lung injury in a rat model of APIP and its possible mechanisms. The APIP model was induced by sodium taurocholate in Sprague-Dawley rats during the third trimester. Sham-operated (SO) rats in late gestation were used as controls, and dynamic observation and detection in the SO and acute pancreatitis (AP) groups were performed at 3 time-points...
September 18, 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/29030078/evaluation-of-the-prognostic-value-of-neutrophil-to-lymphocyte-ratio-in-patients-with-hypertriglyceridemia-induced-acute-pancreatitis
#18
Yuchen Wang, Harry E Fuentes, Bashar M Attar, Palash Jaiswal, Melchor Demetria
INTRODUCTION: Recent studies attribute promising prognostic values to various inflammatory biomarkers in acute pancreatitis, including the following: the neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), and red cell distribution width (RDW). We aimed to determine the performance of these biomarkers for detecting disease severity in patients with hypertriglyceridemia-induced acute pancreatitis (HTG-AP). METHODS: We retrospectively reviewed 110 patients with HTG-AP and compared the NLR, PLR, and RDW in different severity groups...
October 6, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/29030007/pretreatment-of-a-matrix-metalloproteases-inhibitor-and-aprotinin-attenuated-the-development-of-acute-pancreatitis-induced-lung-injury-in-rat-model
#19
Kuang-En Chu, Yao Fong, David Wang, Chao Fuh Chen, Diana Yu-Wung Yeh
OBJECTIVE: Acute lung injury (ALI) is one of the most common extra-pancreatic complications of acute pancreatitis. In this study, we examined the protective effect of protease inhibitor aprotinin and a matrix metalloproteinase inhibitor (MMPi) on pulmonary inflammation in rats with severe pancreatitis-associated ALI. METHOD: A rat model of acute pancreatitis (AP) was established by injecting sodium glycodeoxycholate (GDOC) into the pancreatic duct. Pharmacological interventions included pretreatment with a protease inhibitor aprotinin (10mg/kg) and a matrix metalloproteinase inhibitor (MMPi, 100g/kg)...
October 6, 2017: Immunobiology
https://www.readbyqxmd.com/read/29017662/-progresses-of-immunomodulatory-therapy-in-sever-acute-pancreatitis
#20
Guangming He, Guanze Xiong, Song Lu, Shanling Xu, Keling Chen
Severe acute pancreatitis (SAP) is accompanied with complex pathogenic course and high mortality. The imbalance of immune response is an important cause which leads the SAP patients to the severe situation and even death. The immunomodulatory therapy can regulate the imbalance of inflammation, alleviate SAP-associated organ injury, and improve the prognosis of patients. Previous immunomodulatory therapy had some problems, such as single-object and simple-method. In recent years, some new methods of immunomodulatory therapy, such as regulating the apoptosis and mature of immune cells, applying of mesenchymal stem cells (MSCs) and multi-regulation methods, provide some new ideas and hopes for SAP therapy...
October 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
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