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https://www.readbyqxmd.com/read/29784441/effect-of-methicillin-resistant-staphylococcus-aureus-in-japan
#1
Hironori Uematsu, Kazuto Yamashita, Seiko Mizuno, Susumu Kunisawa, Keigo Shibayama, Yuichi Imanaka
BACKGROUND: Methicillin-resistant Staphylococcus aureus (MRSA) is the most common antimicrobial-resistant organism identified in Japanese health care facilities. This study analyzed the clinical and economic burdens attributable to methicillin resistance in S aureus in Japanese hospitals. METHODS: We retrospectively investigated data from 14,905 inpatients of 57 hospitals combined with data from nosocomial infection surveillance and administrative claim databases...
May 18, 2018: American Journal of Infection Control
https://www.readbyqxmd.com/read/29782796/resolution-measurement-from-a-single-reconstructed-cryo-em-density-map-with-multi-scale-spectral-analysis
#2
Yu-Jiao Yang, Shuai Wang, Biao Zhang, Hong-Bin Shen
As a relatively new technology to solve the 3D structure of a protein or protein complex, the Single-Particle Reconstruction (SPR) of cryo-EM images shows much superiority and is in a rapidly developing stage. Resolution measurement in SPR, which evaluates the quality of a reconstructed 3D density map, plays a critical role for promoting methodology development of SPR and structural biology. Due to there is no benchmark map in a new structure generation, how to realize the resolution estimation of a new map is still an open problem...
May 21, 2018: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/29781425/clinical-predictors-of-methicillin-resistance-and-their-impact-on-mortality-associated-with-staphylococcus-aureus-bacteraemia
#3
Y M Wi, J Y Rhee, C I Kang, D R Chung, J H Song, K R Peck
We investigated the clinical predictors of methicillin-resistance and their impact on mortality in 371 patients with Staphylococcus aureus bacteraemia identified from two prospective multi-centre studies. Methicillin resistant S. aureus (MRSA) accounted for 42.2% of community-onset and 74.5% of hospital-onset cases. No significant clinical difference was found between patients infected with MRSA vs. methicillin-sensitive S. aureus (MSSA), except that the former were more likely to have had hospital-onset bacteraemia and received antibiotics in the preceding 90 days...
May 21, 2018: Epidemiology and Infection
https://www.readbyqxmd.com/read/29762662/national-costs-associated-with-methicillin-susceptible-and-methicillin-resistant-s-aureus-hospitalizations-in-the-united-states-2010-2014
#4
Eili Y Klein, Wendi Jiang, Nestor Mojica, Katie K Tseng, Ryan McNeill, Sara E Cosgrove, Trish M Perl
Background: Infections caused by methicillin-resistant Staphylococcus aureus (MRSA) have been associated with worse patient outcomes and higher costs of care than susceptible (MSSA) infections. However, the healthcare landscape has changed since prior studies found these differences, including widespread dissemination of community-associated strains of MRSA. Our objective was to provide updated estimates of the excess costs of resistant S. aureus infections. Methods: We conducted a retrospective analysis using data from the National Inpatient Sample from the Agency for Healthcare Research and Quality for the years 2010 to 2014...
May 12, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29758967/multi-subject-subspace-alignment-for-non-stationary-eeg-based-emotion-recognition
#5
Xin Chai, Qisong Wang, Yongping Zhao, Xin Liu, Dan Liu, Ou Bai
Emotion recognition based on EEG signal is a critical component in Human-Machine collaborative environments and psychiatric health diagnoses. However, EEG patterns have been found to vary across subjects due to user fatigue, different electrode placements, and varying impedances, etc. This problem renders the performance of EEG-based emotion recognition highly specific to subjects, requiring time-consuming individual calibration sessions to adapt an emotion recognition system to new subjects. Recently, domain adaptation (DA) strategies have achieved a great deal success in dealing with inter-subject adaptation...
April 22, 2018: Technology and Health Care: Official Journal of the European Society for Engineering and Medicine
https://www.readbyqxmd.com/read/29734776/an-ointment-consisting-of-the-phage-lysin-lysgh15-and-apigenin-for-decolonization-of-methicillin-resistant-staphylococcus-aureus-from-skin-wounds
#6
Mengjun Cheng, Lei Zhang, Hao Zhang, Xinwei Li, Yanmei Wang, Feifei Xia, Bin Wang, Ruopeng Cai, Zhimin Guo, Yufeng Zhang, Yalu Ji, Changjiang Sun, Xin Feng, Liancheng Lei, Yongjun Yang, Wenyu Han, Jingmin Gu
Staphylococcus aureus ( S. aureus ) is a common and dangerous pathogen that causes various infectious diseases. Skin damage, such as burn wounds, are at high risk of Staphylococcus aureus colonization and infection, which increases morbidity and mortality. The phage lysin LysGH15 exhibits highly efficient lytic activity against methicillin-resistant S. aureus (MRSA) and methicillin-susceptible S. aureus (MSSA) strains. Apigenin (api) significantly decreases haemolysis of rabbit erythrocytes caused by S. aureus and shows anti-inflammatory function...
May 6, 2018: Viruses
https://www.readbyqxmd.com/read/29724187/effects-of-intestinal-colonization-by-clostridium-difficile-and-staphylococcus-aureus-on-microbiota-diversity-in-healthy-individuals-in-china
#7
Danfeng Dong, Qi Ni, Chen Wang, Lihua Zhang, Zhen Li, Cen Jiang, EnqiangMao, Yibing Peng
BACKGROUND: Intestinal colonization by pathogenic bacteria is a risk factor for infection, and contributes to environmental contamination and disease dissemination. Alteration of gut microbiota also plays a pivotal role in the development of disease. Although Clostridium difficile and Staphylococcus aureus are well-recognized pathogens causing nosocomial and community infections, the intestinal colonization was not fully investigated. Herein, we explored their overall carriage rates in healthy adults from the community, and characterized the gut microbiomes of C...
May 3, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29720527/improved-subtyping-of-staphylococcus-aureus-clonal-complex-8-strains-based-on-whole-genome-phylogenetic-analysis
#8
Jolene R Bowers, Elizabeth M Driebe, Valerie Albrecht, Linda K McDougal, Mitchell Granade, Chandler C Roe, Darrin Lemmer, J Kamile Rasheed, David M Engelthaler, Paul Keim, Brandi M Limbago
Strains of Staphylococcus aureus in clonal complex 8 (CC8), including USA300, USA500, and the Iberian clone, are prevalent pathogens in the United States, both inside and outside health care settings. Methods for typing CC8 strains are becoming obsolete as the strains evolve and diversify, and whole-genome sequencing has shown that some strain types fall into multiple sublineages within CC8. In this study, we attempt to clarify the strain nomenclature of CC8, classifying the major strain types based on whole-genome sequence phylogenetics using both methicillin-resistant S...
June 27, 2018: MSphere
https://www.readbyqxmd.com/read/29716725/staphylococcus-aureus-colonization-in-an-institutionalized-elderly-population-long-term-care-facilities-in-the-bay-of-cadiz-area-spain-prevalence-and-associated-risk-factors
#9
María Pérez-Eslava, Nuria López-Ruíz, Elvira María Flores-Cebada, Manuel Rodríguez-Iglesias, Fátima Galán-Sánchez
BACKGROUND AND OBJECTIVE: Staphylococcus aureus is a health problem behind a great variety of infections. The objective of the study was to establish the prevalence and risk factors of S. aureus carriers in community nursing homes in Cadiz. PATIENTS AND METHOD: A cross study from September 2016 to May 2017. POPULATION: All residents institutionalized in the largest long-term care facilities centers in Cadiz. The main variable was being a S...
April 28, 2018: Medicina Clínica
https://www.readbyqxmd.com/read/29714149/mupirocin-resistance-among-methicillin-resistant-staphylococcus-isolates-in-a-tertiary-health-care-center
#10
Seema Mittal, Pallavi Sayal
INTRODUCTION-Antibiotics have revolutionized medicine in many respects and countless lives have been saved, their discovery was a turning point in human history. Regrettably, the use of these wonder drugs has been accompanied by the rapid appearance of resistant strains. AIMS &OBJECTIVES-This study was carried out to with the aim to determine the rates of high-level and low-level mupirocin resistance in MRSA, to study the antimicrobial resistance pattern of mupirocin-resistant MRSA and mupirocin-sensitive MRSA...
April 30, 2018: Infectious Disorders Drug Targets
https://www.readbyqxmd.com/read/29707662/molecular-analysis-of-immune-evasion-cluster-iec-genes-and-intercellular-adhesion-gene-cluster-ica-among-methicillin-resistant-and-methicillin-sensitive-isolates-of-staphylococcus-aureus
#11
R Ahmadrajabi, S Layegh-Khavidaki, D Kalantar-Neyestanaki, Y Fasihi
Introduction: Resistance to antibiotics and presence of virulence factors play an important role in increased mortality associated with infection due to Staphylococcus aureus. In this study, we determine antibiotic resistance pattern, presence of the icaADBC locus as well as biofilm formation and distribution and diversity the immune evasion cluster (IEC) genes in clinical isolate of S. aureus from Kerman, Iran. Materials and methods: During 15 months, 100 clinical isolates S...
December 2017: Journal of Preventive Medicine and Hygiene
https://www.readbyqxmd.com/read/29693635/commensal-staphylococcus-aureus-provokes-immunity-to-protect-against-skin-infection-of-methicillin-resistant-staphylococcus-aureus
#12
John-Jackson Yang, Ting-Wei Chang, Yong Jiang, Hsin-Jou Kao, Bin-Hao Chiou, Ming-Shan Kao, Chun-Ming Huang
Unlike USA300, a strain of community-acquired methicillin-resistant Staphylococcus aureus (MRSA), commensal Staphylococcus aureus ( S. aureus ) bacteria isolated from human skin demonstrated the ability to mediate the glycerol fermentation to produce short-chain fatty acids (SCFAs). Quantitative proteomic analysis of enzymes involved in glycerol fermentation demonstrated that the expression levels of six enzymes, including glycerol-3-phosphate dehydrogenase (GPDH) and phosphoglycerate mutase (PGM), in commensal S...
April 25, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29692937/ebv-associated-lymphoproliferative-disorder-and-hemophagocytic-lymphohistiocytosis-in-a-patient-with-severe-celiac-disease
#13
John Jacob Kinross-Wright, Kalyan Chakravarthy Potu, Brandy Pownell, Randall Lamfers, Jonathan S Bleeker
Background: Epstein-Barr virus- (EBV-) associated lymphoproliferative disease (LPD) is a rare condition, usually occurring in immunocompromised patients. We report a case of EBV-associated LPD in a patient with severe celiac disease, the first report to describe this syndrome in a patient with this diagnosis. Case Summary: A 69-year-old Caucasian woman with recent diagnosis of celiac sprue presented to our hospital with persistent diarrhea, abdominal pain, weight loss, and fatigue despite adherence to gluten-free diet for a number of weeks prior to presentation...
2018: Case Reports in Hematology
https://www.readbyqxmd.com/read/29689698/aggression-impulsivity-and-their-predictive-value-on-medical-lethality-of-suicide-attempts-a-follow-up-study-on-hospitalized-patients
#14
Yari Gvion
BACKGROUND: This study examined the role of aggressive-impulsive variants, and suicide history in predicting the medical severity of follow-up suicide attempts. METHODS: 97 consecutive psychiatric in-patients who participated in earlier study 2-5 years previously. Thirty-three had a history of a medically serious suicide attempt (MSSA), 29 had a history of a medically non-serious suicide attempt (MNSSA), and 35 had no history of suicide. Participants completed a battery of instruments measuring aggressive-impulsive variables, hopelessness and communication difficulties...
February 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29680503/chitosan-tailored-lipidic-nanoconstructs-of-fusidic-acid-as-promising-vehicle-for-wound-infections-an-explorative-study
#15
Kanika Thakur, Gajanand Sharma, Bhupinder Singh, Sanjay Chhibber, A B Patil, Om Prakash Katare
The current research study intends to explore the combined potential of lipid nanoparticles and chitosan as an optimum therapy for the management of wound infections. Fusidic acid (FA), a steroidal antibiotic employed for treatment of primary and secondary topical infections was encapsulated within the nanoengineered lipid-polymer hybrid nanoparticles (FA-LPHNs). A number of variables like lipid/polymer ratio, lipid, surfactant and chitosan concentration, stirring speed were optimized to get the desired particle size and % entrapment efficiency...
April 19, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29676483/molecular-characteristics-of-antimicrobial-resistance-and-virulence-determinants-of-staphylococcus-aureus-isolates-derived-from-clinical-infection-and-food
#16
Kui Luo, Fuye Shao, Kadijatu N Kamara, Shuaiyin Chen, Rongguang Zhang, Guangcai Duan, Haiyan Yang
BACKGROUND: Staphylococcus aureus (S. aureus) is an important human etiologic agent. An investigation of the characteristics of common genotypes of S. aureus relating to pathogenicity and antibiotic resistance may provide a foundation to prevent infection. METHODS: This study collected 275 S. aureus isolates from Zhengzhou city in China, including 148 isolates from patient samples and 127 isolates from ready-to-eat food samples. Antimicrobial susceptibility testing was performed using the broth dilution method...
April 20, 2018: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/29673980/photoactivated-2-3-distyrylindoles-kill-multi-drug-resistant-bacteria
#17
Leslie Edwards, Danielle Turner, Cody Champion, Megha Khandelwal, Kailee Zingler, Cassidy Stone, Ruwini D Rajapaksha, Jing Yang, Mahinda I Ranasinghe, Alexander Kornienko, Liliya V Frolova, Snezna Rogelj
Compounds based on the 2,3-distyrylindole scaffold were found to exhibit bactericidal properties upon irradiation with white light. At the concentration of 1 μM, the lead compound 1 completely (ca. 109  CFU/mL) eradicated such Gram-positive organisms as S. aureus (MRSA, MSSA), E. faecalis (VRE), S. pyogenes and S. mutans when irradiated with white light for 2 min. At the concentration of 5 μM and in the presence of polymyxin E at non-bactericidal 1.25 μg/mL concentration, 1 also showed a 7-log to 9-log reductions in bacterial counts of such Gram-negative organisms as multi-drug resistant (MDR) A...
April 3, 2018: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29673157/optimization-of-stress-based-microfluidic-testing-for-methicillin-resistance-in-staphylococcus-aureus-strains
#18
Maxim Kalashnikov, Jean C Lee, Alexis F Sauer-Budge
The rapid evolution of antibiotic resistance in bacterial pathogens is driving the development of innovative, rapid antibiotic susceptibility testing (AST) tools as a way to provide more targeted and timely antibiotic treatment. We have previously presented a stress-based microfluidic method for the rapid determination of antibiotic susceptibility in methicillin-susceptible Staphylococcus aureus (MSSA) and methicillin-resistant Staphylococcus aureus (MRSA). In this method, stress is used to potentiate the action of antibiotics, and cell death is measured as a proxy for susceptibility...
April 17, 2018: Diagnostics
https://www.readbyqxmd.com/read/29671723/evaluation-of-staphylococcus-aureus-eradication-therapy-in-orthopaedic-surgery
#19
S T J Tsang, M P McHugh, D Guerendiain, P Gwynne, J Boyd, I F Laurenson, K E Templeton, S Lewis, A H R W Simpson, T S Walsh
PURPOSE: Despite WHO recommendations, there is currently no national screening and eradication policy for the detection of methicillin-sensitive Staphylococcus aureus (MSSA) in the UK prior to elective orthopaedic surgery. This study aimed to evaluate the effectiveness of current standard methicillin-resistant S. aureus (MRSA) eradication therapies in the context of S. aureus (both MRSA and MSSA) decolonization in an elective orthopaedic population. METHODOLOGY: A total of 100 patients awaiting joint replacement surgery who were positive for S...
April 19, 2018: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/29661650/community-acquired-methicillin-resistant-staphylococcus-aureus-can-persist-in-the-throat
#20
Aida Hamdan-Partida, Samuel González-García, Estela de la Rosa García, Jaime Bustos-Martínez
Colonization by Staphylococcus aureus is an important factor in infections caused by this microorganism. Among the colonization niches of staphylococci are the nose, skin, intestinal tract, and, recently, the throat has been given relevance. Infections caused by community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) can be fatal. Persistence of S. aureus is an important process in the pathogenesis of this microorganism and must be studied. The aim of this study was to determine the persistence of S...
April 12, 2018: International Journal of Medical Microbiology: IJMM
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