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https://www.readbyqxmd.com/read/29452455/complex-hur-function-in-pancreatic-cancer-cells
#1
REVIEW
Jonathan R Brody, Dan A Dixon
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers with dismal patient outcomes. The underlying core genetic drivers of disease have been identified in human tumor specimens and described in genetically engineered mouse models. These genetic drivers of PDAC include KRAS signaling, TP53 mutations, and genetic loss of the SMAD4 tumor suppressor protein. Beyond the known mutational landscape of PDAC genomes, alternative disrupted targets that extend beyond conventional genetic mutations have been elusive and understudied in the context of PDAC cell therapeutic resistance and survival...
February 16, 2018: Wiley Interdisciplinary Reviews. RNA
https://www.readbyqxmd.com/read/29452406/negative-association-between-sclerostin-and-insl3-in-isolated-human-osteocytes-and-in-klinefelter-syndrome-new-hints-for-testis-bone-crosstalk
#2
Andrea Di Nisio, Luca De Toni, Maria Santa Rocca, Marco Ghezzi, Riccardo Selice, Giuseppe Taglialavoro, Alberto Ferlin, Carlo Foresta
Context/Objective: The regulation of bone mass by the testis is a well-recognized mechanism, but the role of Leydig-specific marker insuline-like 3 peptide (INSL3) on the most abundant bone cell population, osteocytes, is unknown. In this study we aimed to investigate the relationship between INSL3 and Sclerostin, an osteocyte-specific protein that negatively regulates bone formation. Design/Setting: Serum sclerostin and INSL3 levels were evaluated in Klinefelter Syndrome (KS) and healthy controls...
February 14, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29452377/discordance-in-the-dependence-on-kisspeptin-signaling-in-mini-puberty-vs-adolescent-puberty-human-genetic-evidence
#3
Muhammad Shahab, Margaret Lippincott, Yee-Ming Chan, Addie Davies, Paulina M Merino, Lacey Plummer, Veronica Mericq, Stephanie Seminara
Context: Hypothalamic kisspeptin signaling plays a critical role in the initiation and maintenance of reproductive function. Biallelic mutations in the coding sequence of KISS1R (GPR54) have been identified in patients with idiopathic hypogonadotropic hypogonadism (IHH), but it is unknown whether biallelic variants can also be associated with related reproductive disorders. Case description: A missense homozygous variant (c.890G>T p.R297L) in KISS1R was identified in a child who presented with microphallus and bilateral cryptorchidism...
February 14, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29452292/prevalence-risk-factors-and-genetic-characterization-of-toxoplasma-gondii-in-sick-pigs-and-stray-cats-in-jiangsu-province-eastern-china
#4
Zhao-Feng Hou, Shi-Jie Su, Dan-Dan Liu, Le-le Wang, Chuan-Li Jia, Zhen-Xing Zhao, Yi-Fei Ma, Qiao-Qiao Li, Jin-Jun Xu, Jian-Ping Tao
Toxoplasma gondii is an obligate intracellular parasitic protozoan with a worldwide distribution. The parasites in edible tissues of pigs and oocysts from cats are the major sources of T. gondii infection in humans. However, there are no data from sick pigs in veterinary clinics or from stray cats in Jiangsu Province, eastern China. In total, biological samples from 141 sick pigs and 64 stray cats were collected from this region. The rate of T. gondii infection in sick pigs was 46.81% using a polymerase chain reaction (PCR), and the overall prevalence of toxoplasmosis in stray cats was 34...
February 13, 2018: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/29452267/git2-a-keystone-in-ageing-and-age-related-disease
#5
REVIEW
Jaana van Gastel, Jan Boddaert, Areta Jushaj, Richard T Premont, Louis M Luttrell, Jonathan Janssens, Bronwen Martin, Stuart Maudsley
Since its discovery, G protein-coupled receptor kinase-interacting protein 2, GIT2, and its family member, GIT1, have received considerable interest concerning their potential key roles in regulating multiple inter-connected physiological and pathophysiological processes. GIT2 was first identified as a multifunctional protein that is recruited to G protein-coupled receptors (GPCRs) during the process of receptor internalization. Recent findings have demonstrated that perhaps one of the most important effects of GIT2 in physiology concerns its role in controlling multiple aspects of the complex ageing process...
February 13, 2018: Ageing Research Reviews
https://www.readbyqxmd.com/read/29452214/pgrn-promotes-lymphangiogenesis-through-vegf-c-and-is-an-independent-risk-factor-in-human-esophageal-cancers
#6
Guanhua Li, Taotao Dong, Dong Yang, Aiqin Gao, Judong Luo, Hongyan Yang, Linlin Wang
Lymph node metastasis is one of the most important predictor of the prognosis for esophageal cancer (EC) patients. Yet, the mechanism underlying the lymph node metastasis is largely unknown. Progranulin (PGRN) is shown to be highly expressed in various types of cancers and could promote the angiogenesis and epithelial mesenchymal transition (EMT) of cancer cells in previous studies. However, the expression status of PGRN and its effects on the lymphangiogenesis in EC is largely unclear. In this study, we show for the first time that PGRN is expressed in EC tissue samples and cell lines and could promote the expression of VEGF-C in vitro, a well-known lymphangiogenesis inducer, through the putative signaling transducers p-ERK and p-AKT...
February 13, 2018: Human Pathology
https://www.readbyqxmd.com/read/29451890/detection-of-bartonella-spp-in-fleas-by-maldi-tof-ms
#7
Basma El Hamzaoui, Maureen Laroche, Lionel Almeras, Jean Michel Bérenger, Didier Raoult, Philippe Parola
BACKGROUND: Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry (MALDI-TOF MS) has recently emerged in the field of entomology as a promising method for the identification of arthropods and the detection of associated pathogens. METHODOLOGY/PRINCIPAL FINDINGS: An experimental model of Ctenocephalides felis (cat fleas) infected with Bartonella quintana and Bartonella henselae was developed to evaluate the efficacy of MALDI-TOF MS in distinguishing infected from uninfected fleas, and its ability to distinguish fleas infected with Bartonella quintana from fleas infected with Bartonella henselae...
February 16, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29451889/effects-of-patterned-peripheral-nerve-stimulation-on-soleus-spinal-motor-neuron-excitability
#8
Samuel Jimenez, Laura Mordillo-Mateos, Michele Dileone, Michela Campolo, Carmen Carrasco-Lopez, Fabricia Moitinho-Ferreira, Tomas Gallego-Izquierdo, Hartwig R Siebner, Josep Valls-Solé, Juan Aguilar, Antonio Oliviero
Spinal plasticity is thought to contribute to sensorimotor recovery of limb function in several neurological disorders and can be experimentally induced in animals and humans using different stimulation protocols. In healthy individuals, electrical continuous Theta Burst Stimulation (TBS) of the median nerve has been shown to change spinal motoneuron excitability in the cervical spinal cord as indexed by a change in mean H-reflex amplitude in the flexor carpi radialis muscle. It is unknown whether continuous TBS of a peripheral nerve can also shift motoneuron excitability in the lower limb...
2018: PloS One
https://www.readbyqxmd.com/read/29451849/a-comprehensive-review-of-eggs-choline-and-lutein-on-cognition-across-the-life-span
#9
Taylor C Wallace
In 2030, one in five Americans will be older than 65 years, and with that an increase in the number of individuals who experience loss in cognitive capacity is to be expected. At the same time, nutrition within the first 1000 days postconception has been suggested to strongly influence cognitive outcomes across the life-span in humans. Eggs are a primary source of both choline and the xanthophyll carotenoid lutein in the western diet, and both have been suggested to influence cognitive function in humans. This comprehensive review critically examines the effects of eggs, choline, and lutein on cognition across the life-span...
February 16, 2018: Journal of the American College of Nutrition
https://www.readbyqxmd.com/read/29451827/sending-the-right-message-wild-game-and-the-west-africa-ebola-outbreak
#10
Kristin Post
The unprecedented scale of the Ebola epidemic in West Africa in 2014-15 caught the world by surprise. Zaire Ebolavirus had not previously been documented in Guinea, Sierra Leone, or Liberia. However, since this strain of filovirus was first identified in 1976, scientists have been studying the disease and its origins. They have identified forest-dwelling animals that carry the virus, and some that die from it, but have yet to isolate how it is transmitted from animals to humans. During the height of the Ebola outbreak in West Africa, some public health messages addressed the link among Ebola, wild animals, and humans...
January 2018: Health Security
https://www.readbyqxmd.com/read/29451788/a-systematic-evaluation-of-the-use-of-human-plasma-and-serum-for-mass-spectrometry-based-shotgun-proteomics
#11
Jiayi Lan, Antonio Núñez Galindo, James Doecke, Christopher Fowler, Ralph N Martins, Stephanie R Rainey-Smith, Ornella Cominetti, Loïc Dayon
Over the last two decades, EDTA-plasma has been used as the preferred sample matrix for human blood proteomic profiling. Serum has also been employed widely. Only a few studies have assessed the difference and relevance of the proteome profiles obtained from plasma samples, such as EDTA-plasma or lithium-heparin-plasma, and serum. A more complete evaluation of the use of EDTA-plasma, heparin-plasma, and serum would greatly expand the comprehensiveness of shotgun proteomics of blood samples. In this study, we evaluated the use of heparin-plasma with respect to EDTA-plasma and serum to profile blood proteomes using a scalable automated proteomic pipeline (ASAP2)...
February 16, 2018: Journal of Proteome Research
https://www.readbyqxmd.com/read/29451495/perceptually-aware-image-retargeting-for-mobile-devices
#12
Yinzuo Zhou, Luming Zhang, Chao Zhang, Ping Li, Xuelong Li
Retargeting aims at adapting an original high-resolution photograph/video to a low-resolution screen with an arbitrary aspect ratio. Conventional approaches are generally based on desktop PCs, since the computation might be intolerable for mobile platforms (especially when retargeting videos). Typically, only low-level visual features are exploited, and human visual perception is not well encoded. In this paper, we propose a novel retargeting framework that rapidly shrinks a photograph/video by leveraging human gaze behavior...
May 2018: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/29451320/commentary-on-the-ema-guideline-on-strategies-to-identify-and-mitigate-risks-for-first-in-human-and-early-clinical-trials-with-investigational-medicinal-products-emea-chmp-swp-28367-07-rev-1
#13
Joop van Gerven, Milton Bonelli
No abstract text is available yet for this article.
February 16, 2018: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29451315/sensitivity-to-the-sampling-process-emerges-from-the-principle-of-efficiency
#14
Julian Jara-Ettinger, Felix Sun, Laura Schulz, Joshua B Tenenbaum
Humans can seamlessly infer other people's preferences, based on what they do. Broadly, two types of accounts have been proposed to explain different aspects of this ability. The first account focuses on spatial information: Agents' efficient navigation in space reveals what they like. The second account focuses on statistical information: Uncommon choices reveal stronger preferences. Together, these two lines of research suggest that we have two distinct capacities for inferring preferences. Here we propose that this is not the case, and that spatial-based and statistical-based preference inferences can be explained by the assumption that agents are efficient alone...
February 16, 2018: Cognitive Science
https://www.readbyqxmd.com/read/29451309/antibodies-to-human-neutrophil-antigen-hna-3b-implicated-in-cases-of-neonatal-alloimmune-neutropenia
#15
Larissa Barbosa Lopes, Samira Ali Abbas, Elyse Moritz, Juliana Oliveira Martins, Akemi Kuroda Chiba, Dante Mário Langhi, José O Bordin
BACKGROUND: Neonatal alloimmune neutropenia results from maternal alloimmunization to human neutrophil antigens. The alloantibodies involved in neonatal alloimmune neutropenia are against human neutrophil antigens HNA-1a, HNA-1b, HNA-1c, HNA-1d, HNA-2, HNA-3a, HNA-4a, HNA-4b, and HNA-5a; however, to date, antibodies specific to HNA-3b have not been reported. STUDY DESIGN AND METHODS: Blood samples from 10,000 unselected neonates were analyzed, resulting in the selection of 88 neutropenic newborns (neutrophil count <1...
February 16, 2018: Transfusion
https://www.readbyqxmd.com/read/29451035/revisiting-the-physiological-effects-of-methylene-blue-as-a-treatment-of-cyanide-intoxication
#16
Philippe Haouzi, Maxime Gueguinou, Takashi Sonobe, Annick Judenherc-Haouzi, Nicole Tubbs, Mohamed Trebak, Joseph Cheung, Frederic Bouillaud
BACKGROUND: Although methylene blue (MB) had long been proposed to counteract the effects of cyanide (CN) intoxication, research on its mechanisms of action and efficacy has been abandoned for decades. Recent studies on the benefits of MB in post-anoxic injuries have prompted us to reexamine the relevance of this historical observation. METHODS: Our study was performed in adult male Sprague-Dawley rats and on HEK293T epithelial cells. First, the effects and toxicity of MB (0-80 mg/kg) on circulation and metabolism were established in four urethane-anesthetized rats...
February 16, 2018: Clinical Toxicology
https://www.readbyqxmd.com/read/29451019/antimicrobial-substances-from-the-rare-actinomycete-nonomuraea-rhodomycinica-nr4-asc07-t
#17
Khomsan Supong, Paranee Sripreechasak, Wongsakorn Phongsopitanun, Somboon Tanasupawat, Kannawat Danwisetkanjana, Nantiya Bunbamrung, Pattama Pittayakhajonwut
Nonomuraea rhodomycinica NR4-ASC07 T is a rare actinomycete isolated from soil in Sirindhorn peat swamp forest. The crude extract of its culture broth exhibited antimicrobial and anticancer against diverse human pathogens and cancer cells. The chemical investigation of the crude extract led to the isolation of two new metabolites named nonomuric acid (1) and 3-hydroxy deoxydaunorubicinol aglycone (2), along with two known bioactive compounds [ε-rhodomycinone (3) and 7-deoxy-13-dihydrocarminomycinone (4)]. Compounds 1 and 3 showed antimalarial activity with the half maximal inhibitory concentration (IC 50 ) of 8...
February 16, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29450992/assessment-of-fragmentation-strategies-for-large-proteins-using-the-multilayer-molecules-in-molecules-approach
#18
Bishnu Thapa, Daniel Beckett, K V Jovan Jose, Krishnan Raghavachari
We present a rigorous evaluation of the potential for the multilayer Molecules-in-Molecules (MIM) fragmentation method to be applied to large biomolecules. Density functional total energies of a test set of 8 peptides, sizes ranging from 107 to 721 atoms, were evaluated with MIM and compared to unfragmented energies to help develop a protocol for the treatment of large proteins. Fragmentation schemes involving subsystems of 4 to 5 covalently bonded fragments (tetramer or pentamer schemes) were tested with a single level of theory (MIM1) and produced errors on the order of 100 kcal/mol due to the relatively small size of the subsystems and the neglect of nonbonded interactions...
February 16, 2018: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/29450895/a-test-of-multi-session-automatic-action-tendency-retraining-to-reduce-alcohol-consumption-among-young-adults-in-the-context-of-a-human-laboratory-paradigm
#19
Robert F Leeman, Christine Nogueira, Reinout W Wiers, Janna Cousijn, Kelly Serafini, Kelly S DeMartini, John A Bargh, Stephanie S O'Malley
BACKGROUND: Young adult heavy drinking is an important public health concern. Current interventions have efficacy but with only modest effects, thus novel interventions are needed. In prior studies, heavy drinkers, including young adults, have demonstrated stronger automatically triggered approach tendencies to alcohol-related stimuli than lighter drinkers. Automatic action tendency retraining has been developed to correct this tendency and consequently reduce alcohol consumption. The current study is the first to test multiple iterations of automatic action tendency retraining, followed by laboratory alcohol self-administration...
February 16, 2018: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/29450634/prevalence-genotypes-and-risk-factors-of-enterocytozoon-bieneusi-in-asiatic-black-bear-ursus-thibetanus-in-yunnan-province-southwestern-china
#20
Jie Wu, Jian-Qiang Han, Lian-Qin Shi, Yang Zou, Zhao Li, Jian-Fa Yang, Cui-Qin Huang, Feng-Cai Zou
Microsporidiosis is an important zoonotic disease, even leading to severe diarrhea. However, no information about prevalence and genotypes of Enterocytozoon bieneusi infection in Asiatic black bears in southwestern China is available. The objectives of the present study were to investigate the prevalence of E. bieneusi and to characterize their genotypes using the nested PCR amplification of the internal transcribed spacer region of the ribosomal RNA gene cluster and multilocus sequence typing (MLST). The overall prevalence of E...
February 15, 2018: Parasitology Research
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