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https://www.readbyqxmd.com/read/28918294/potassium-channels-modulate-the-action-but-not-the-synthesis-of-hydrogen-sulfide-in-rat-corpus-cavernosum
#1
H Abd Elmoneim, F Sharabi, M Mohy El Din, L Louedec, X Norel, A Senbel
AIM: Hydrogen sulfide (H2S) is a newly-introduced gasotransmitter in penile tissues. However, its exact mechanism of action in mediating penile erection is not fully elucidated. The major aim of this study was to examine the role of different K(+) channels in mediating the responses to H2S in the corpus cavernosum. MAIN METHODS: Tension studies using isolated rat corpus cavernosum strips were conducted. Endogenous H2S production was measured using polarographic technique...
September 13, 2017: Life Sciences
https://www.readbyqxmd.com/read/28916719/kir2ds2-recognizes-conserved-peptides-derived-from-viral-helicases-in-the-context-of-hla-c
#2
Mohammed M Naiyer, Sorcha A Cassidy, Andrea Magri, Vanessa Cowton, Kevin Chen, Salah Mansour, Hariklia Kranidioti, Berenice Mbirbindi, Pauline Rettman, Scott Harris, Liam J Fanning, Arend Mulder, Franz H J Claas, Andrew D Davidson, Arvind H Patel, Marco A Purbhoo, Salim I Khakoo
Killer cell immunoglobulin-like receptors (KIRs) are rapidly evolving species-specific natural killer (NK) cell receptors associated with protection against multiple different human viral infections. We report that the activating receptor KIR2DS2 directly recognizes viral peptides derived from conserved regions of flaviviral superfamily 2 RNA helicases in the context of major histocompatibility complex class I. We started by documenting that peptide LNPSVAATL from the hepatitis C virus (HCV) helicase binds HLA-C*0102, leading to NK cell activation through engagement of KIR2DS2...
September 15, 2017: Science Immunology
https://www.readbyqxmd.com/read/28912774/therapeutic-antibodies-to-kir3dl2-and-other-target-antigens-on-cutaneous-t-cell-lymphomas
#3
REVIEW
Christian Schmitt, Anne Marie-Cardine, Armand Bensussan
KIR3DL2 is a member of the killer cell immunoglobulin-like receptor (KIR) family that was initially identified at the surface of natural killer (NK) cells. KIR3DL2, also known as CD158k, is expressed as a disulfide-linked homodimer. Each chain is composed of three immunoglobulin-like domains and a long cytoplasmic tail containing two immunoreceptor tyrosine-based inhibitory motifs. Beside its expression on NK cells, it is also found on rare circulating T lymphocytes, mainly CD8(+). Although the KIR gene number varies between haplotype, KIR3DL2 is a framework gene present in all individuals...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28911739/role-of-inward-rectifier-potassium-channels-in-salivary-gland-function-and-sugar-feeding-of-the-fruit-fly-drosophila-melanogaster
#4
Daniel R Swale, Zhilin Li, Felix Guerrero, Adalberto A Pérez De León, Lane D Foil
The arthropod salivary gland is of critical importance for horizontal transmission of pathogens, yet a detailed understanding of the ion conductance pathways responsible for saliva production and excretion is lacking. A superfamily of potassium ion channels, known as inward rectifying potassium (Kir) channels, is overexpressed in the Drosophila salivary gland by 32-fold when compared to the whole body mRNA transcripts. Therefore, we aimed to test the hypothesis that pharmacological and genetic depletion of salivary gland specific Kir channels alters the efficiency of the gland and reduced feeding capabilities using the fruit fly Drosophila melanogaster as a model organism that could predict similar effects in arthropod disease vectors...
September 2017: Pesticide Biochemistry and Physiology
https://www.readbyqxmd.com/read/28903385/dpp-4-enzyme-deficiency-protects-kidney-from-acute-ischemia-reperfusion-injury-role-for-remote-intermittent-bowel-ischemia-reperfusion-preconditioning
#5
Yen-Ta Chen, Christopher Glenn Wallace, Chih-Chao Yang, Chih-Hung Chen, Kuan-Hung Chen, Pei-Hsun Sung, Yung-Lung Chen, Han-Tan Chai, Sheng-Ying Chung, Sarah Chua, Fan-Yen Lee, Sheung-Fat Ko, Mel S Lee, Hon-Kan Yip
We analyzed the effects of acute ischemia-reperfusion (KIR) injury on the status of kidney function and architecture in dipeptidyl peptidase4-difficient (DPP4(D)) rats and the effect of remote small bowel ischemia-reperfusion (BIR) preconditioning. DPP4-deficient (DPP4(D)) and normal Fischer344 (F344) rats were divided into 6 groups: (1) sham-F344, (2) sham-DPP4(D), (3) KIR-F344 (4) KIR-DPP4(D), (5) DPP4(D)-KIR-extendin-9-39 and (6) BIR-KIR-F344. Blood creatinine and urea nitrogen levels and the urinary protein-to-creatinine ratio was higher in KIR-F344 rats than BIR-KIR-F344 or KIR-DPP4(D) rats 72 h after acute KIR...
August 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28900399/acacetin-from-traditionally-used-saussurea-involucrata-kar-et-kir-suppressed-adipogenesis-in-3t3-l1-adipocytes-and-attenuated-lipid-accumulation-in-obese-mice
#6
Chian-Jiun Liou, Shu-Ju Wu, Li-Chen Chen, Kuo-Wei Yeh, Chih-Ying Chen, Wen-Chung Huang
Acacetin, a flavone that can be isolated from the Saussurea involucrata plant, has anti-tumor and anti-inflammatory properties that ameliorate airway hyperresponsiveness in asthmatic mice. This study investigated whether acacetin has anti-adipogenic effects in 3T3-L1 adipocytes and whether it regulates the inflammatory response in adipocytes and macrophages. It also investigated whether acacetin ameliorates lipid accumulation in high-fat diet- (HFD) induced obese mice. Differentiated 3T3-L1 cells were treated with acacetin...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28898393/is-beh%C3%A3-et-s-disease-a-class-1-opathy-the-role-of-hla-b-51-in-the-pathogenesis-of-beh%C3%A3-et-s-disease
#7
REVIEW
Mark Giza, Danai Koftori, Liye Chen, Paul Bowness
The association between carriage of the HLA-B*51 allele and development of Behçet's Disease (BD) has been known since the early 1970s, but the exact mechanisms responsible for its role in pathogenesis remain much-debated. In an effort to explain the disease process, it has been suggested that BD constitutes one of a newly-termed group of diseases, the 'MHC-I-opathies'. Other MHC-I-opathies' include Ankylosing Spondylitis and other HLA-B*27-associated spondyloarthropathies, and HLA-C*0602-associated skin psoriasis...
September 12, 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/28890284/activity-dependent-changes-in-transporter-and-potassium-currents-in-hippocampal-astrocytes
#8
REVIEW
Albina Lebedeva, Alex Plata, Olga Nosova, Olga Tyurikova, Alexey Semyanov
Astrocytes are involved in maintenance of synaptic microenvironment by glutamate uptake and K(+) clearance. These processes are associated with net charge transfer across the membrane and therefore can be recorded as glutamate transporter (IGluT) and K(+) (IK) currents. It has been previously shown that the blockade of IK with BaCl2 enhances the IGluT. Here we show that activity-dependent facilitation (5 stimuli at 50Hz) of IGluT was not significantly different in BaCl2 compared to facilitation of IGluT isolated by post-hoc subtraction of IK...
September 7, 2017: Brain Research Bulletin
https://www.readbyqxmd.com/read/28878071/zika-virus-escapes-nk-cell-detection-by-upregulating-mhc-class-i-molecules
#9
Ariella Glasner, Esther Oiknine-Djian, Yiska Weisblum, Mohammad Diab, Amos Panet, Dana G Wolf, Ofer Mandelboim
NK cells are innate lymphocytes that participate in many immune processes encompassing cancer, bacterial and fungal infection, autoimmunity and even pregnancy and are specialize in anti-viral defense. NK cells express inhibitory and activating receptors and kill their targets when activating signals overpower the inhibitory ones. The NK cell inhibitory receptors compose of a uniquely diverse array of proteins named Killer-cell immunoglobulin-like receptors (KIRs) the CD94 family and the leukocyte immunoglobulin like receptor family (LIR)...
September 6, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28876452/management-of-primary-malignant-bone-and-soft-tissue-tumors-of-foot-and-ankle-is-it-worth-salvaging
#10
Harzem Özger, Buğra Alpan, Osman Emre Aycan, Natig Valiyev, Mustafa Çağlar Kir, Fulya Ağaoğlu
BACKGROUND AND OBJECTIVE: Performing limb salvage with safe margins and preserving meaningful function is very difficult in the setting of primary malignant bone and soft tissue tumors due to the complex and constrained anatomy of the foot and ankle. The study aims to evaluate the efficacy of limb salvage procedures in terms of functional and oncological outcomes. METHODS: Clinical data of 48 patients, who underwent surgical treatment between 1992 and 2015 in our institution, were retrospectively analyzed...
September 6, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28867344/nk-cell-alloreactivity-against-kir-ligand-mismatched-hla-haploidentical-tissue-derived-from-hla-haplotype-homozygous-ipscs
#11
Hiroshi Ichise, Seiji Nagano, Takuya Maeda, Masaki Miyazaki, Yuki Miyazaki, Hiroto Kojima, Nobuyo Yawata, Makoto Yawata, Hidenori Tanaka, Hiroh Saji, Kyoko Masuda, Hiroshi Kawamoto
HLA haplotype-homozygous (HLA-homo) induced pluripotent stem cells (iPSCs) are being prepared to be used for allogeneic transplantation of regenerated tissue into recipients carrying an identical haplotype in one of the alleles (HLA-hetero). However, it remains unaddressed whether natural killer (NK) cells respond to these regenerated cells. HLA-C allotypes, known to serve as major ligands for inhibitory receptors of NK cells, can be classified into group 1 (C1) and group 2 (C2), based on their binding specificities...
September 12, 2017: Stem Cell Reports
https://www.readbyqxmd.com/read/28862100/arthroscopy-assisted-versus-standard-intramedullary-nail-fixation-in-diaphyseal-fractures-of-the-humerus
#12
Süleyman Semih Dedeoğlu, Yunus İmren, Haluk Çabuk, Ali Çağrı Tekin, Mustafa Çağlar Kır, Hakan Gürbüz
PURPOSE: The aim of this study was to assess applicability of arthroscopic technique in intramedullary nail fixation of humerus shaft fractures and to compare with conventional nailing in terms of its effects on perioperative and postoperative intra-articular complication rates as well as on clinical and functional outcomes. METHODS: This prospective randomized controlled clinical trial included 40 patients (12 females and 28 males) indicated for surgery between either undergo arthroscopy-assisted (Arthroscopy-assisted intramedullary nailing [AIMN]; n = 20) or conventional (Intramedullary nailing [IMN]; n = 20) anterograde intramedullary nailing...
September 2017: Journal of Orthopaedic Surgery
https://www.readbyqxmd.com/read/28862099/association-of-killer-cell-immunoglobulin-like-receptor-kir-genes-and-their-hla-ligands-with-susceptibility-to-beh%C3%A3-et-s%C3%A2-disease
#13
H Mohammad-Ebrahim, E Kamali-Sarvestani, M Mahmoudi, M Beigy, J Karami, N Ahmadzadeh, F Shahram
OBJECTIVES: Behçet's disease (BD) is a systemic inflammatory disorder with remissions and exacerbations. It is thought that defects in the natural killer (NK) cell repertoire may be involved in BD through killer cell immunoglobulin-like receptors (KIRs). This study aimed to evaluate KIR and HLA genes, their interactions in BD patients, and their associations with clinical manifestations. METHOD: The presence or absence of KIR and HLA alleles and genotypes was analysed by polymerase chain reaction sequence-specific primer on genomic DNA of 397 BD patients and 300 healthy controls...
September 1, 2017: Scandinavian Journal of Rheumatology
https://www.readbyqxmd.com/read/28855109/the-vasorelaxant-effect-of-mitiglinide-via-activation-of-voltage-dependent-k-channels-and-serca-pump-in-aortic-smooth-muscle
#14
Hongliang Li, Hye Won Kim, Sung Eun Shin, Mi Seon Seo, Jin Ryeol An, Kwon-Soo Ha, Eun-Taek Han, Seok-Ho Hong, Amy L Firth, Il-Whan Choi, Il Yong Han, Dae-Sung Lee, Mi-Jin Yim, Won Sun Park
AIMS: The vasorelaxant effects of the anti-diabetic drug, mitiglinide in phenylephrine (Phe)-pre-contracted aortic rings were examined. MATERIALS AND METHODS: Arterial tone measurement was performed in aortic smooth muscle cells. KEY FINDINGS: Mitiglinide dose-dependently induced vasorelaxation. Application of the large-conductance Ca(2+)-activated K(+) (BKCa) channel blocker paxilline, inwardly rectifying K(+) (Kir) channel blocker Ba(2+), and ATP-sensitive K(+) (KATP) channel blocker glibenclamide did not affect the vasorelaxant effect of mitiglinide...
August 27, 2017: Life Sciences
https://www.readbyqxmd.com/read/28845855/-role-of-combination-nk-kirs-in-the-natural-history-of-viral-infections
#15
Claudia Colomba, Antonio Cascio, Calogero Caruso, Marcello Trizzino, Claudia Gioè, Giuliana Guadagnino, Antonino Tuttolomondo, Antonio Pinto, Annalisa Saracino, Gioacchino Angarano, Danilo Di Bona
Immunological mechanisms involved in the genesis of the immune response against viral infections take into account the activation of both innate adaptative response. Innate immune defenses trigger a rapid local response, which is often sufficient to control viral infection, and promotes the subsequent activation of specific immune defenses. Natural killer (NK) cells that constitute a subpopulation of lymphocyte-related cells are a key factor of innate immune response and play a role in defense against viral infections by killing infected cells or by producing cytokines and interacting with adaptative immune system's cells...
July 2017: Recenti Progressi in Medicina
https://www.readbyqxmd.com/read/28845331/atypical-central-serous-chorioretinopathy
#16
Zafer Cebeci, Merih Oray, Şerife Bayraktar, İlknur Tuğal-Tutkun, Nur Kır
Bullous central serous chorioretinopathy (CSCR) is a rare variant of CSCR characterized by severe serous retinal detachment which especially involves the inferior quadrants. Corticosteroid therapy administered for systemic or ocular misdiagnoses may induce and exacerbate CSCR. The purpose of this study was to report diagnosis and treatment results of an unusual case of bullous CSCR induced by systemic and periocular corticosteroid therapy received at another medical center due to a misdiagnosis of Vogt-Koyanagi-Harada disease...
August 2017: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/28835490/asymptomatic-primary-infection-with-epstein-barr-virus-observations-on-young-adult-cases
#17
Rachel J Abbott, Annette Pachnio, Isabela Pedroza-Pacheco, Alison M Leese, Jusnara Begum, Heather M Long, Debbie Croom-Carter, Andrea Stacey, Paul A H Moss, Andrew D Hislop, Persephone Borrow, Alan B Rickinson, Andrew I Bell
Epstein-Barr virus (EBV) is typically acquired asymptomatically in childhood. By contrast, infection later in life often leads to infectious mononucleosis (IM), a febrile illness characterised by anti-EBV IgM antibody-positivity, high loads of circulating latently-infected B cells, and a marked lymphocytosis caused by hyper-expansion of EBV-specific CD8(+) T cells plus milder expansion of CD56(dim) NKG2A(+) KIR(-) NK cells. How the two situations compare is unclear due to the paucity of studies on clinically-silent infection...
August 23, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28834298/the-vasorelaxant-effect-of-anti-diabetic-drug-nateglinide-via-activation-of-voltage-dependent-k-channels-in-aortic-smooth-muscle
#18
Hongliang Li, Hye Won Kim, Sung Eun Shin, Mi Seon Seo, Jin Ryeol An, Won-Kyo Jung, Kwon-Soo Ha, Eun-Taek Han, Seok-Ho Hong, Hyoweon Bang, Il-Whan Choi, Sung Hun Na, Won Sun Park
AIMS: We investigated the vasorelaxant effect of nateglinide and its related mechanisms using phenylephrine (Phe)-induced pre-contracted aortic rings. METHODS: Arterial tone measurement was performed in aortic smooth muscle. RESULTS: The application of nateglinide induced vasorelaxation in a concentration-dependent manner. Pretreatment with the large conductance Ca(2+) -activated K(+) (BKCa ) channel inhibitor paxilline, the inwardly rectifying K(+) (Kir) channel inhibitor Ba(2+) , and ATP-sensitive K(+) (KATP ) channel inhibitor glibenclamide, did not affect the vasorelaxant effect of nateglinide...
August 20, 2017: Cardiovascular Therapeutics
https://www.readbyqxmd.com/read/28817402/the-importance-of-natural-killer-cell-killer-immunoglobulin-like-receptor-mismatch-in-transplant-outcomes
#19
Kate Stringaris, Austin J Barrett
PURPOSE OF REVIEW: In recent years, the rules of engagement between natural killer (NK) cells and their targets have become better defined with the identification of an array of NK surface molecules, notably the killer immunoglobulin-like (KIR) receptors and their ligands on target cells through which signals of activation or suppression of NK function are mediated. After allogeneic stem cell transplantation (SCT), the opportunity for NK cell activation can occur both in human leucocyte antigen (HLA) matched and HLA mismatched pairs...
August 16, 2017: Current Opinion in Hematology
https://www.readbyqxmd.com/read/28812990/human-leukocyte-antigen-c-12-02-02-and-killer-immunoglobulin-like-receptor-2dl5-are-distinctly-associated-with-ankylosing-spondylitis-in-the-taiwanese
#20
Chin-Man Wang, Sheng-Hung Wang, Yeong-Jian Jan Wu, Jing-Chi Lin, Jianming Wu, Ji-Yih Chen
Human leukocyte antigen (HLA) class I ligands and Killer immunoglobulin-like receptors (KIRs) regulate the cytolytic activity of natural killer (NK) cells and certain T cells. We examined their genetic predisposition to disease susceptibility and clinical phenotypes in Taiwanese ankylosing spondylitis (AS) patients. KIR genotyping and Human Leucocyte Antigen C (HLA-C) sequencing were performed in 653 Taiwanese AS patients and 952 healthy controls. KIR genotype distributions and HLA-C allele frequencies were compared in patients and controls and among patients with and without HLA-B27 positivity, early age onset and spinal syndesmophytes...
August 16, 2017: International Journal of Molecular Sciences
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