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https://www.readbyqxmd.com/read/28314864/systematic-model-of-peripheral-inflammation-after-subarachnoid-hemorrhage
#1
Jude P J Savarraj, Kaushik Parsha, Georgene W Hergenroeder, Liang Zhu, Suhas S Bajgur, Sungho Ahn, Kiwon Lee, Tiffany Chang, Dong H Kim, Yin Liu, H Alex Choi
OBJECTIVE: To investigate inflammatory processes after aneurysmal subarachnoid hemorrhage (aSAH) with network models. METHODS: This is a retrospective observational study of serum samples from 45 participants with aSAH analyzed at multiple predetermined time points: <24 hours, 24 to 48 hours, 3 to 5 days, and 6 to 8 days after aSAH. Concentrations of cytokines were measured with a 41-plex human immunoassay kit, and the Pearson correlation coefficients between all possible cytokine pairs were computed...
March 17, 2017: Neurology
https://www.readbyqxmd.com/read/28298564/proteomic-analysis-of-sera-from-individuals-with-diffuse-cutaneous-systemic-sclerosis-reveals-a-multianalyte-signature-associated-with-clinical-improvement-during-imatinib-mesylate-treatment
#2
D James Haddon, Hannah E Wand, Justin A Jarrell, Robert F Spiera, Paul J Utz, Jessica K Gordon, Lorinda S Chung
OBJECTIVE: Imatinib has been investigated for the treatment of systemic sclerosis (SSc) because of its ability to inhibit the platelet-derived growth factor receptor and transforming growth factor-β signaling pathways, which have been implicated in SSc pathogenesis. In a 12-month open-label clinical trial assessing the safety and efficacy of imatinib in the treatment of diffuse cutaneous SSc (dcSSc), significant improvements in skin thickening were observed. Here, we report our analysis of sera collected during the clinical trial...
March 15, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28294424/therapeutic-regulation-of-systemic-inflammation-in-xenograft-recipients
#3
Hayato Iwase, Hong Liu, Tao Li, Zhongquiang Zhang, Bingsi Gao, Hidetaka Hara, Martin Wijkstrom, Cassandra Long, Ryan Saari, David Ayares, David K C Cooper, Mohamed B Ezzelarab
Inflammation is known to preclude tolerance after transplantation. We have previously shown that systemic inflammation in xenograft recipients (SIXR) precedes activation of coagulation in the absence of T cell responses. Accordingly, SIXR may amplify innate and adaptive immune responses against xenografts after pig-to-primate xenotransplantation, even with efficient immunosuppressive therapy. We evaluated the impact of anti-inflammatory agents on pro-inflammatory cytokines and chemokines in pig artery patch and heart xenograft recipients...
March 12, 2017: Xenotransplantation
https://www.readbyqxmd.com/read/28294314/generation-of-precursor-immature-and-mature-murine-b1-cell-lines-from-c-myc-bcl-xl-overexpressing-pre-bi-cells
#4
Inge Wolf, Corinne Bouquet, Friederike Naumann, Fritz Melchers
Deregulated expression of c-myc and bcl-xL is long known to generate transformed B cells in humans and mice. We overexpressed these genes to induce in vitro and in vivo differentiation of fetal liver-derived mouse pre-BI cells to B1-lineage pre-BII-like, immature and mature B-cell lines and to Ig-secreting cells. In vitro, doxycycline-controlled c-myc/bcl-xL-overexpressing CD19(+) CD93(+) c-kikt(+) IgM(-) pre-BI cells differentiate to and survive as CD19(+) CD93(+) c-kit(-) IgM(+) immature B1 cells. Timed CpG-stimulation of these oncogene-overexpressing pre-B or immature B1 cells generates either CD19(+) CD93(low) c-kit(-) IgM(-) SLC(-) pre-BII-like, or IgM(+) MHCII(+) CD73(+) CD80(+) CD40(+) mature B1-cell lines and IgM-secreting B1 cells in vitro and fixes their state of differentiation...
March 10, 2017: European Journal of Immunology
https://www.readbyqxmd.com/read/28289417/murine-cytomegalovirus-infection-induces-susceptibility-to-eae-in-resistant-balb-c-mice
#5
Jelena Milovanovic, Branka Popovic, Marija Milovanovic, Daria Kvestak, Aleksandar Arsenijevic, Bojana Stojanovic, Irena Tanaskovic, Astrid Krmpotic, Nebojsa Arsenijevic, Stipan Jonjic, Miodrag L Lukic
In contrast to C57BL/6 mice, BALB/c mice are relatively resistant to the induction of experimental autoimmune encephalomyelitis (EAE) after challenge with MOG35-55 peptide. Here, we provide the first evidence that infection with murine cytomegalovirus (MCMV) in adulthood abrogates this resistance. Infected BALB/c mice developed clinical and histological signs similar to those seen in susceptible C57BL/6 mice. In addition to CD4(+) cells, large proportion of cells in the infiltrate of diseased BALB/c mice was CD8(+), similar with findings in multiple sclerosis...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28287031/comparison-of-diverse-platelet-activation-markers-as-indicators-for-left-atrial-thrombus-in-atrial-fibrillation
#6
Daniel Tarnowski, David M Poitz, Lina Plichta, Felix M Heidrich, Stephan Wiedemann, Tobias Ruf, Johannes Mierke, Tobias Löhn, Stefanie Jellinghaus, Ruth H Strasser, Karim Ibrahim, Christian Pfluecke
Atrial fibrillation (AF) is well known for being a major risk factor of thromboembolic stroke. We could recently demonstrate an association of monocyte-platelet aggregates (MPAs) with the degree of thrombogenicity in patients with AF. This study investigated platelet activation markers, as potential biomarkers for the presence of left atrial (LA) thrombus in patients with AF. One hundred and eight patients with symptomatic AF underwent transesophageal echocardiography (TEE) before scheduled cardioversion or pulmonary vein isolation...
March 13, 2017: Platelets
https://www.readbyqxmd.com/read/28286252/pkc-epsilon-and-tlr4-synergistically-regulate-resistin-mediated-inflammation-in-human-macrophages
#7
Mary C Zuniga, Gayatri Raghuraman, Elizabeth Hitchner, Cornelia Weyand, William Robinson, Wei Zhou
BACKGROUND AND AIMS: Resistin has been associated with atherosclerotic inflammation and cardiovascular complications. We and others have previously shown that PKC-epsilon (PKCε) is involved in resistin-induced smooth muscle cell (VSMC) dysfunction at a high pathological concentration. This study aimed to evaluate the role and potential pathways of resistin at a physiological concentration, in atherosclerosis-related inflammation. METHODS: Plasma from patients with atherosclerosis was analyzed for resistin concentration...
February 24, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28284329/soluble-cd40-ligand-contributes-to-blood-brain-barrier-breakdown-and-central-nervous-system-inflammation-in-multiple-sclerosis-and-neuromyelitis-optica-spectrum-disorder
#8
Hiroki Masuda, Masahiro Mori, Tomohiko Uchida, Akiyuki Uzawa, Ryohei Ohtani, Satoshi Kuwabara
Soluble CD40 ligand (sCD40L) is reported to disrupt the blood-brain barrier (BBB). Cerebrospinal fluid (CSF) and serum sCD40L levels were measured in 29 multiple sclerosis (MS), 29 neuromyelitis optica spectrum disorder (NMOSD), and 27 disease control (DC) patients. In MS, serum sCD40L levels were higher than in DCs and positively correlated with the CSF/serum albumin ratio (Qalb). In NMOSD, CSF sCD40L levels were significantly increased compared to DCs, and were correlated to Qalb, CSF cell counts, protein concentrations, and interleukin-6 levels...
April 15, 2017: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/28282583/control-of-immune-escaped-human-papilloma-virus-is-regained-after-therapeutic-vaccination
#9
REVIEW
Wenbo Ma, Cornelis Jm Melief, Sjoerd H van der Burg
High-risk human papillomaviruses infect the basal cells of human epithelia. There it deploys several mechanisms to suppress pathogen receptor recognition signalling, impeding the immune system to control viral infection. Furthermore, infected cells become more resistant to type I and II interferon, tumour necrosis factor-α and CD40 activation, via interference with downstream programs halting viral replication or regulating the proliferation and cell death. Consequently, some infected individuals fail to raise early protein-specific T-cell responses that are strong enough to protect against virus-induced premalignant disease and ultimately cancer...
March 7, 2017: Current Opinion in Virology
https://www.readbyqxmd.com/read/28281187/mir-145-5p-regulates-hypoxia-induced-inflammatory-response-and-apoptosis-in-cardiomyocytes-by-targeting-cd40
#10
Ming Yuan, Liwei Zhang, Fei You, Jingyu Zhou, Yongjiang Ma, Feifei Yang, Ling Tao
An increasing body of evidence indicates that inflammation and apoptosis are involved in the development of acute myocardial infarction (AMI). In this study, we sought to investigate the specific role and the underlying regulatory mechanism of miR-145-5p in myocardial ischemic injury. H9c2 cardiac cells were exposed to hypoxia to establish a model of myocardial hypoxic/ischemic injury. We found that miR-145-5p was notably down-regulated, while CD40 expression was highly elevated in H9c2 cells following exposure to acute hypoxia...
March 9, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28279082/effects-of-immunization-and-checkpoint-inhibition-on-amodiaquine-induced-liver-injury
#11
Alastair Mak, Alexander Johnston, Jack Uetrecht
If idiosyncratic drug-induced liver injury (IDILI) is immune-mediated, it is possible that an individual's prior exposure to antigens may affect their susceptibility to IDILI. An individual's repertoire of memory immune cells is shaped by every past exposure to antigens. Subsequent drug-induced adverse drug reactions may therefore involve an immune cell's cross reactivity between a prior antigen and resulting drug-modified proteins. Therefore in this experiment, mice were immunized with amodiaquine (AQ)-modified hepatic proteins to mimic a previous exposure; treated with a RIBI adjuvant and anti-CD40 antibodies to stimulate an immune response; and, treated with anti-PD1 and anti-CTLA-4 antibodies prior to AQ treatment in order to overcome immune tolerance...
December 2017: Journal of Immunotoxicology
https://www.readbyqxmd.com/read/28276457/cd40-signalling-abrogates-induction-of-ror%C3%AE-t-treg-cells-by-intestinal-cd103-dcs-and-causes-fatal-colitis
#12
Christian Barthels, Ana Ogrinc, Verena Steyer, Stefanie Meier, Ferdinand Simon, Maria Wimmer, Andreas Blutke, Tobias Straub, Ursula Zimber-Strobl, Esther Lutgens, Peggy Marconi, Caspar Ohnmacht, Debora Garzetti, Bärbel Stecher, Thomas Brocker
Immune homeostasis in intestinal tissues depends on the generation of regulatory T (Treg) cells. CD103(+) dendritic cells (DCs) acquire microbiota-derived material from the gut lumen for transport to draining lymph nodes and generation of receptor-related orphan γt(+) (RORγt(+)) Helios(-)-induced Treg (iTreg) cells. Here we show CD40-signalling as a microbe-independent signal that can induce migration of CD103(+) DCs from the lamina propria (LP) to the mesenteric lymph nodes. Transgenic mice with constitutive CD11c-specific CD40-signalling have reduced numbers of CD103(+) DCs in LP and a low frequency of RORγt(+)Helios(-) iTreg cells, exacerbated inflammatory Th1/Th17 responses, high titres of microbiota-specific immunoglobulins, dysbiosis and fatal colitis, but no pathology is detected in other tissues...
March 9, 2017: Nature Communications
https://www.readbyqxmd.com/read/28275176/human-bronchial-epithelium-orchestrates-dendritic-cell-activation-in-severe-asthma
#13
Delphine Gras, Asuncion Martinez-Anton, Arnaud Bourdin, Celine Garulli, Laure de Senneville, Isabelle Vachier, Joana Vitte, Pascal Chanez
The innate immune response is impaired in asthma, with increased epithelial release of C-X-C motif chemokine ligand (CXCL)8, interleukin (IL)-33 and thymic stromal lymphopoietin (TSLP). We hypothesised that dendritic cells might modulate the hyperresponsive epithelium in severe asthma.For this purpose, we investigated epithelial-dendritic crosstalk in normal and diseased conditions, and because ultrafine particulate matter may affect asthmatic airways, we investigated its impact on this crosstalk. Air-liquid interface cultures of human bronchial epithelial cells (HBEC) of control subjects (cHBEC) or severe asthma patients (saHBEC) were co-cultured with monocyte-derived dendritic cells (moDC)...
March 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28275136/distinct-and-overlapping-functions-of-tec-kinase-and-btk-in-b-cell-receptor-signaling
#14
Marjolein J W de Bruijn, Jasper Rip, Esmee K van der Ploeg, Lars W van Greuningen, Van T B Ta, Laurens P Kil, Anton W Langerak, Guus F Rimmelzwaan, Wilfried Ellmeier, Rudi W Hendriks, Odilia B J Corneth
The Tec tyrosine kinase is expressed in many cell types, including hematopoietic cells, and is a member of the Tec kinase family that also includes Btk. Although the role of Btk in B cells has been extensively studied, the role of Tec kinase in B cells remains largely unclear. It was previously shown that Tec kinase has the ability to partly compensate for loss of Btk activity in B cell differentiation, although the underlying mechanism is unknown. In this study, we confirm that Tec kinase is not essential for normal B cell development when Btk is present, but we also found that Tec-deficient mature B cells showed increased activation, proliferation, and survival upon BCR stimulation, even in the presence of Btk...
March 8, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28273064/class-iia-hdac-inhibition-reduces-breast-tumours-and-metastases-through-anti-tumour-macrophages
#15
Jennifer L Guerriero, Alaba Sotayo, Holly E Ponichtera, Jessica A Castrillon, Alexandra L Pourzia, Sara Schad, Shawn F Johnson, Ruben D Carrasco, Suzan Lazo, Roderick T Bronson, Scott P Davis, Mercedes Lobera, Michael A Nolan, Anthony Letai
Although the main focus of immuno-oncology has been manipulating the adaptive immune system, harnessing both the innate and adaptive arms of the immune system might produce superior tumour reduction and elimination. Tumour-associated macrophages often have net pro-tumour effects, but their embedded location and their untapped potential provide impetus to discover strategies to turn them against tumours. Strategies that deplete (anti-CSF-1 antibodies and CSF-1R inhibition) or stimulate (agonistic anti-CD40 or inhibitory anti-CD47 antibodies) tumour-associated macrophages have had some success...
March 8, 2017: Nature
https://www.readbyqxmd.com/read/28267402/cd40-ligand-is-increased-in-mast-cells-in-psoriasis-and-actinic-keratosis-but-less-so-in-epithelial-skin-carcinomas
#16
Salla Haimakainen, Antti P Kaukinen, Mireille-Maria Suttle, Jukka Pelkonen, Ilkka T Harvima
The expression of CD40 ligand (CD40L) in mast cells was investigated in biopsies from lesional and non-lesional skin samples of patients with psoriasis, actinic keratosis (AK), basal cell carcinoma, and squamous cell carcinoma using a sequential double-staining technique. The percentage of CD40L(+) mast cells was higher in the lesional than in the non-lesional skin (p < .003). Interestingly, this percentage was lower in both carcinomas than in psoriasis and actinic keratosis (p < .025). Cells immunopositive for CD40 receptor were increased in all lesion types but especially so in carcinomas...
March 16, 2017: Cancer Investigation
https://www.readbyqxmd.com/read/28261209/gm-csf-inhibits-c-kit-and-scf-expression-by-bone-marrow-derived-dendritic-cells
#17
Amairelys Belen Barroeta Seijas, Sonia Simonetti, Sara Vitale, Daniele Runci, Angela Caterina Quinci, Alessandra Soriani, Mattia Criscuoli, Irene Filippi, Antonella Naldini, Federico Maria Sacchetti, Umberto Tarantino, Francesco Oliva, Eleonora Piccirilli, Angela Santoni, Francesca Di Rosa
Stem cell factor (SCF), the ligand of c-kit, is a key cytokine for hematopoiesis. Hematopoietic precursors express c-kit, whereas differentiated cells of hematopoietic lineage are negative for this receptor, with the exception of NK cells, mast cells, and a few others. While it has long been recognized that dendritic cells (DCs) can express c-kit, several questions remain concerning the SCF/c-kit axis in DCs. This is particularly relevant for DCs found in those organs wherein SCF is highly expressed, including the bone marrow (BM)...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28250776/allogeneic-adipose-derived-mesenchymal-stromal-cells-ameliorate-experimental-autoimmune-encephalomyelitis-by-regulating-self-reactive-t-cell-responses-and-dendritic-cell-function
#18
Per Anderson, Elena Gonzalez-Rey, Francisco O'Valle, Francisco Martin, F Javier Oliver, Mario Delgado
Multipotent mesenchymal stromal cells (MSCs) have emerged as a promising therapy for autoimmune diseases, including multiple sclerosis (MS). Administration of MSCs to MS patients has proven safe with signs of immunomodulation but their therapeutic efficacy remains low. The aim of the current study has been to further characterize the immunomodulatory mechanisms of adipose tissue-derived MSCs (ASCs) in vitro and in vivo using the EAE model of chronic brain inflammation in mice. We found that murine ASCs (mASCs) suppress T cell proliferation in vitro via inducible nitric oxide synthase (iNOS) and cyclooxygenase- (COX-) 1/2 activities...
2017: Stem Cells International
https://www.readbyqxmd.com/read/28241397/an-in-vitro-investigation-of-the-marked-impact-of-dendritic-cell-interactions-with-bone-grafts
#19
Lili Zhang, Jin Ke, Yulan Wang, Shuang Yang, Richard J Miron, Yufeng Zhang
The immune response to bone biomaterials plays a critical role during early inflammation and biomaterial-induced osteogenesis. Dendritic cells (DCs) possess a significant impact during immune responses to biomaterials. While conventional strategies to evaluate the osteogenic potential of bone substitute materials focus mainly on osteoblast differentiation. Therefore the present study was to investigate the interactions DCs to porous β-tricalcium phosphate (β-TCP) to investigate whether DCs participate in the material-coordinated osteogenic process...
February 27, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28239788/expression-of-surface-molecules-in-human-mesenchymal-stromal-cells-co-cultured-with-nucleated-umbilical-cord-blood-cells
#20
Yu A Romanov, E E Balashova, N E Volgina, N V Kabaeva, T N Dugina, G T Sukhikh
We studied the expression of different classes of surface molecules (CD13, CD29, CD40, CD44, CD54, CD71, CD73, CD80, CD86, CD90, CD105, CD106, CD146, HLA-I, and HLA-DR) in mesenchymal stromal cells from human umbilical cord and bone marrow during co-culturing with nucleated umbilical cord blood cells. Expression of the majority of surface markers in both types of mesenchymal stromal cells was stable and did not depend on the presence of the blood cells. Significant differences were found only for cell adhesion molecules CD54 (ICAM-1) and CD106 (VCAM-1) responsible for direct cell-cell contacts with leukocytes and only for bone marrow derived cells...
February 2017: Bulletin of Experimental Biology and Medicine
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