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https://www.readbyqxmd.com/read/27884144/assessment-of-serology-and-spirometry-and-the-combination-of-both-to-complement-microbiological-isolation-for-earlier-detection-of-pseudomonas-aeruginosa-infection-in-children-with-cystic-fibrosis
#1
Ana Kotnik Pirš, Uroš Krivec, Saša Simčič, Katja Seme
BACKGROUND: The aim of this study was to assess whether serology and spirometry and the combination of both can complement culture-based detection for earlier recognition of Pseudomonas aeruginosa infection in children with cystic fibrosis. METHODS: A 4 year longitudinal prospective study that included 67 Slovenian children with cystic fibrosis with a mean age of 10.5 years was conducted. Serology, spirometry and a scoring system combining serology and spirometry were assessed and compared...
November 25, 2016: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/27865134/polychromatic-light-480-3400nm-similar-to-the-terrestrial-solar-spectrum-without-its-uv-component-in-post-surgical-immunorehabilitation-of-breast-cancer-patients
#2
Natalia A Zhevago, Alexander A Zimin, Tatyana V Glazanova, Natalia I Davydova, Natalia V Bychkova, Zhanna V Chubukina, Anna I Buinyakova, Marina F Ballyuzek, Kira A Samoilova
To this day, two methods of phototherapy (PT) have been successfully used in post-surgical immunorehabilitation of patients with breast cancer (BC): intravenous laser irradiation of the patients' blood and reinfusion of lympholeukosuspension of BC patients after single irradiation with HeNe laser. The objective of this pilot experimental study was to verify the effectiveness of the percutaneous use of polychromatic visible light combined with polychromatic infrared (pVIS+pIR) radiation similar to the major components of natural solar spectrum in post-surgical management of BC patients...
November 5, 2016: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/27851824/variant-exported-blood-stage-proteins-encoded-by-plasmodium-multigene-families-are-expressed-in-liver-stages-where-they-are-exported-into-the-parasitophorous-vacuole
#3
Aurélie Fougère, Andrew P Jackson, Dafni Paraskevi Bechtsi, Joanna A M Braks, Takeshi Annoura, Jannik Fonager, Roberta Spaccapelo, Jai Ramesar, Séverine Chevalley-Maurel, Onny Klop, Annelies M A van der Laan, Hans J Tanke, Clemens H M Kocken, Erica M Pasini, Shahid M Khan, Ulrike Böhme, Christiaan van Ooij, Thomas D Otto, Chris J Janse, Blandine Franke-Fayard
Many variant proteins encoded by Plasmodium-specific multigene families are exported into red blood cells (RBC). P. falciparum-specific variant proteins encoded by the var, stevor and rifin multigene families are exported onto the surface of infected red blood cells (iRBC) and mediate interactions between iRBC and host cells resulting in tissue sequestration and rosetting. However, the precise function of most other Plasmodium multigene families encoding exported proteins is unknown. To understand the role of RBC-exported proteins of rodent malaria parasites (RMP) we analysed the expression and cellular location by fluorescent-tagging of members of the pir, fam-a and fam-b multigene families...
November 2016: PLoS Pathogens
https://www.readbyqxmd.com/read/27832656/perifocal-inflammatory-reaction-with-volume-fluctuation-caused-by-diagnostic-radiation-induced-regression-in-germinoma-makes-histological-diagnosis-difficult-despite-its-disappearance-following-treatment-a-significant-pitfall-and-countermeasures-to-it
#4
Yuichiro Yoneoka, Junichi Yoshimura, Masayasu Okada, Yukihiko Fujii
We present a pediatric case of neurohypophyseal germinoma with a perifocal inflammatory reaction (PIR) with volume fluctuation caused by diagnostic radiation-induced regression (DRIR). On-target biopsy failed to confirm the histology because PIR hardly contained any germinoma cells. DRIR-related fluctuation of the tumor volume disguised germinoma as inflammation. We analyzed the cerebrospinal fluid (CSF) and detected a high level of placental alkaline phosphatase (PLAP), which demonstrated the neurohypophyseal lesion to be germinoma and brought the patient from successful radiochemotherapy up to complete remission...
November 11, 2016: Pediatric Neurosurgery
https://www.readbyqxmd.com/read/27830199/qualitative-evaluation-of-anterior-segment-in-angle-closure-disease-using-anterior-segment-optical-coherence-tomography
#5
Sasan Moghimi, Rebecca Chen, Nikoo Hamzeh, Nassim Khatibi, Shan C Lin
PURPOSE: To evaluate different mechanisms of primary angle closure (PAC) and to quantify anterior chamber (AC) parameters in different subtypes of angle closure disease using anterior segment optical coherence tomography (AS-OCT). METHODS: In this prospective study, 115 eyes of 115 patients with angle closure disease were included and categorized into three groups: 1) fellow eyes of acute angle closure (AAC; 40 eyes); 2) primary angle closure glaucoma (PACG; 39 eyes); and 3) primary angle closure suspect (PACS; 36 eyes)...
December 2016: Journal of Current Ophthalmology
https://www.readbyqxmd.com/read/27828022/frequency-domain-phase-noise-analysis-of-dual-injection-locked-optoelectronic-oscillators
#6
Sajad Jahanbakht
Dual injection-locked optoelectronic oscillators (DIL-OEOs) have been introduced as a means to achieve very low-noise microwave oscillations while avoiding the large spurious peaks that occur in the phase noise of the conventional single-loop OEOs. In these systems, two OEOs are inter-injection locked to each other. The OEO with the longer optical fiber delay line is called the master OEO, and the other is called the slave OEO. Here, a frequency domain approach for simulating the phase noise spectrum of each of the OEOs in a DIL-OEO system and based on the conversion matrix approach is presented...
October 1, 2016: Applied Optics
https://www.readbyqxmd.com/read/27798849/dusp11-activity-on-triphosphorylated-transcripts-promotes-argonaute-association-with-noncanonical-viral-micrornas-and-regulates-steady-state-levels-of-cellular-noncoding-rnas
#7
James M Burke, Rodney P Kincaid, Ryan M Nottingham, Alan M Lambowitz, Christopher S Sullivan
RNA silencing is a conserved eukaryotic gene expression regulatory mechanism mediated by small RNAs. In Caenorhabditis elegans, the accumulation of a distinct class of siRNAs synthesized by an RNA-dependent RNA polymerase (RdRP) requires the PIR-1 phosphatase. However, the function of PIR-1 in RNAi has remained unclear. Since mammals lack an analogous siRNA biogenesis pathway, an RNA silencing role for the mammalian PIR-1 homolog (dual specificity phosphatase 11 [DUSP11]) was unexpected. Here, we show that the RNA triphosphatase activity of DUSP11 promotes the RNA silencing activity of viral microRNAs (miRNAs) derived from RNA polymerase III (RNAP III) transcribed precursors...
September 15, 2016: Genes & Development
https://www.readbyqxmd.com/read/27782828/spatial-transcriptome-analysis-reveals-notch-pathway-associated-prognostic-markers-in-idh1-wild-type-glioblastoma-involving-the-subventricular-zone
#8
Christine Jungk, Andreas Mock, Janina Exner, Christoph Geisenberger, Rolf Warta, David Capper, Amir Abdollahi, Sara Friauf, Bernd Lahrmann, Niels Grabe, Philipp Beckhove, Andreas von Deimling, Andreas Unterberg, Christel Herold-Mende
BACKGROUND: The spatial relationship of glioblastoma (GBM) to the subventricular zone (SVZ) is associated with inferior patient survival. However, the underlying molecular phenotype is largely unknown. We interrogated an SVZ-dependent transcriptome and potential location-specific prognostic markers. METHODS: mRNA microarray data of a discovery set (n = 36 GBMs) were analyzed for SVZ-dependent gene expression and process networks using the MetaCore™ workflow...
October 26, 2016: BMC Medicine
https://www.readbyqxmd.com/read/27740454/cyclin-kinase-independent-role-of-p21-cdkn1a-in-the-promotion-of-nascent-dna-elongation-in-unstressed-cells
#9
Sabrina F Mansilla, Agustina P Bertolin, Valérie Bergoglio, Marie-Jeanne Pillaire, Marina A González Besteiro, Carlos Luzzani, Santiago G Miriuka, Christophe Cazaux, Jean-Sébastien Hoffmann, Vanesa Gottifredi
The levels of the cyclin-dependent kinase (CDK) inhibitor p21 are low in S phase and insufficient to inhibit CDKs. We show here that endogenous p21, instead of being residual, it is functional and necessary to preserve the genomic stability of unstressed cells. p21depletion slows down nascent DNA elongation, triggers permanent replication defects and promotes the instability of hard-to-replicate genomic regions, namely common fragile sites (CFS). The p21's PCNA interacting region (PIR), and not its CDK binding domain, is needed to prevent the replication defects and the genomic instability caused by p21 depletion...
October 14, 2016: ELife
https://www.readbyqxmd.com/read/27730514/intranasal-insulin-administration-ameliorates-streptozotocin-icv-induced-insulin-receptor-dysfunction-neuroinflammation-amyloidogenesis-and-memory-impairment-in-rats
#10
N Rajasekar, Chandishwar Nath, Kashif Hanif, Rakesh Shukla
Alzheimer's disease (AD) is associated with reduced insulin level and impairment of insulin receptor (IR) signaling in the brain, which correlates to amyloid pathology, neuroinflammation, and synaptic neurotoxicity. Clinical studies show that intranasal insulin improves memory in AD patients without peripheral hypoglycemia. However, neuroprotective molecular mechanism of the beneficial effect of intranasal insulin in AD pathology is unexplored. Therefore, we investigated the role of intranasal insulin on intracerebroventricular (ICV) streptozotocin (STZ)-induced memory impairment in rats as evaluated in the Morris water maze test...
October 11, 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/27706595/genetic-diversity-in-natural-populations-of-mangaba-in-sergipe-the-largest-producer-state-in-brazil
#11
A N R Soares, M F Vitória, A L S Nascimento, A S Ledo, A R C Rabbani, A V C Silva
Mangaba (Hancornia speciosa Gomes) is found in areas of coastal tablelands in the Brazilian Northeast and Cerrado regions. This species has been subjected to habitat fragmentation that is mainly due to human activity, and requires conservation strategies. The aim of this study was to analyze the structure and inter- and intrapopulation genetic diversity of natural populations of H. speciosa Gomes using inter-simple sequence repeat (ISSR) molecular markers. A total of 155 individuals were sampled in 10 natural populations (ITA, PAC, IND, EST, BC, PIR, JAP, BG, NEO, and SANT) in the State of Sergipe, Brazil...
August 19, 2016: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/27690103/transcript-abundance-of-photorhabdus-insect-related-pir-toxin-in-manduca-sexta-and-galleria-mellonella-infections
#12
Anaïs Castagnola, Geraldine Mulley, Nathaniel Davis, Nicholas Waterfield, S Patricia Stock
In this study, we assessed pirAB toxin transcription in Photorhabdus luminescens laumondii (strain TT01) (Enterobacteriaceae) by comparing mRNA abundance under in vivo and in vitro conditions. In vivo assays considered both natural and forced infections with two lepidopteran hosts: Galleria mellonella and Manduca sexta. Three portals of entry were utilized for the forced infection assays: (a) integument; (b) the digestive route (via mouth and anus); and (c) the tracheal route (via spiracles). We also assessed plu4093-2 transcription during the course of a natural infection; this is when the bacteria are delivered by Heterorhabditis bacteriophora nematodes...
September 29, 2016: Toxins
https://www.readbyqxmd.com/read/27686302/age-related-cataract-and-its-types-in-patients-with-and-without-type-2-diabetes-mellitus-a-hospital-based-comparative-study
#13
Abdul Fattah Memon, Pir Salim Mahar, Muhammad Saleh Memon, Seema N Mumtaz, Sikander Ali Shaikh, Muhammad Faisal Fahim
OBJECTIVE: To determine the frequency and types of age-related cataract in type 2 diabetic patients compared to non-diabetics. METHODS: This comparative, cross-sectional study was carried out at Al-Ibrahim Eye Hospital, Karachi, from July 2014 to June 2015, and comprised both diabetics and non-diabetics. All patients were selected from the out-patient department and had their full ocular examination done, including retinal screening of diabetic patients with non-mydriatic fundus camera...
October 2016: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/27670841/hyperexcitability-of-mesencephalic-trigeminal-neurons-and-reorganization-of-ion-channel-expression-in-a-rett-syndrome-model
#14
Max F Oginsky, Ningren Cui, Weiwei Zhong, Christopher M Johnson, Chun Jiang
People with Rett syndrome (RTT) have defects in motor function also seen in Mecp2-null mice. Motor function depends on not only central motor commands but also sensory feedback that is vulnerable to changes in excitability of propriosensory neurons. Here we report evidence for hyperexcitability of mesencephalic trigeminal (Me5) neurons in Mecp2-null mice and a novel cellular mechanism for lowering its impact. In in-vitro brain slices, the Me5 neurons in both Mecp2(-/Y) male and symptomatic Mecp2(+/-) female mice were overly excitable showing increased firing activity in comparison to their wild-type (WT) male and asymptomatic counterparts...
September 27, 2016: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/27669814/a-comparison-of-the-use-of-cone-beam-computed-tomography-and-panoramic-radiography-in-the-assessment-of-pre-eruptive-intracoronal-resorption
#15
Omer Demirtas, Asım Dane, Eren Yildirim
OBJECTIVE: This study aimed to investigate the prevalence of pre-eruptive intracoronal resorption (PIR) using cone beam computed tomography (CBCT) and panoramic radiography and to compare the findings of these imaging techniques. METHODS: This retrospective study consisted of 733 patients who had at least one unerupted tooth and had undergoneimaging with both three-dimensional (3D) CBCT and two-dimensional (2D) panoramic radiography. In all the images, the number of teeth with intracoronal resorption, affected tooth type and number, and size and location of the PIR defects were recorded...
September 27, 2016: Acta Odontologica Scandinavica
https://www.readbyqxmd.com/read/27659206/patients-with-severe-to-profound-hearing-impairment-and-simultaneous-severe-vision-impairment-a-quality-of-life-study
#16
Satu Turunen-Taheri, Åsa Skagerstrand, Sten Hellström, Per-Inge Carlsson
CONCLUSIONS: Patients with severe vision impairment in combination with severe-to-profound hearing loss seem to have a higher risk for effects on QoL, including: mobility, the ability to provide self-care and perform usual activities, and levels of anxiety and depression, compared with patients with only severe-to-profound hearing loss. OBJECTIVES: To study the quality-of-life (QoL) and audiological rehabilitation of the severely vision-impaired patient population among adults with severe-to-profound hearing loss in Sweden...
September 23, 2016: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/27638512/distribution-of-corticotropin-releasing-factor-neurons-in-the-mouse-brain-a-study-using-corticotropin-releasing-factor-modified-yellow-fluorescent-protein-knock-in-mouse
#17
Junko Kono, Kohtarou Konno, Ashraf Hossain Talukder, Toshimitsu Fuse, Manabu Abe, Katsuya Uchida, Shuhei Horio, Kenji Sakimura, Masahiko Watanabe, Keiichi Itoi
We examined the morphological features of corticotropin-releasing factor (CRF) neurons in a mouse line in which modified yellow fluorescent protein (Venus) was expressed under the CRF promoter. We previously generated the CRF-Venus knock-in mouse, in which Venus is inserted into the CRF gene locus by homologous recombination. In the present study, the neomycin phosphotransferase gene (Neo), driven by the pgk-1 promoter, was deleted from the CRF-Venus mouse genome, and a CRF-Venus∆Neo mouse was generated. Venus expression is much more prominent in the CRF-Venus∆Neo mouse when compared to the CRF-Venus mouse...
September 16, 2016: Brain Structure & Function
https://www.readbyqxmd.com/read/27603710/modelling-the-dynamics-of-post-vaccination-immunity-rate-in-a-population-of-sahelian-sheep-after-a-vaccination-campaign-against-peste-des-petits-ruminants-virus
#18
Pachka Hammami, Renaud Lancelot, Matthieu Lesnoff
BACKGROUND: Peste des petits ruminants (PPR) is an acute infectious viral disease affecting domestic small ruminants (sheep and goats) and some wild ruminant species in Africa, the Middle East and Asia. A global PPR control strategy based on mass vaccination-in regions where PPR is endemic-was recently designed and launched by international organizations. Sahelian Africa is one of the most challenging endemic regions for PPR control. Indeed, strong seasonal and annual variations in mating, mortality and offtake rates result in a complex population dynamics which might in turn alter the population post-vaccination immunity rate (PIR), and thus be important to consider for the implementation of vaccination campaigns...
2016: PloS One
https://www.readbyqxmd.com/read/27599198/rna-based-coacervates-as-a-model-for-membraneless-organelles-formation-properties-and-interfacial-liposome-assembly
#19
William M Aumiller, Fatma Pir Cakmak, Bradley W Davis, Christine D Keating
Liquid-liquid phase separation is responsible for formation of P granules, nucleoli, and other membraneless subcellular organelles composed of RNA and proteins. Efforts to understand the physical basis of liquid organelle formation have thus far focused on intrinsically disordered proteins (IDPs) as major components that dictate occurrence and properties. Here, we show that complex coacervates composed of low complexity RNA (polyuridylic acid, polyU) and short polyamines (spermine and spermidine) share many features of IDP-based coacervates...
October 4, 2016: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/27584006/is-the-partners-in-recovery-program-connecting-with-the-intended-population-of-people-living-with-severe-and-persistent-mental-illness-what-are-their-prioritised-needs
#20
Nicola Hancock, Jennifer Smith-Merry, James A Gillespie, Ivy Yen
Objective The Partners in Recovery (PIR) program is an Australian government initiative designed to make the mental health and social care sectors work in more coordinated ways to meet the needs of those with severe and complex mental illness. Herein we reflect on demographic data collected during evaluation of PIR implementation in two Western Sydney sites. The aims of the present study were to: (1) explore whether two Sydney-based PIR programs had recruited their intended population, namely people living with severe and persistent mental illness; and (2) learn more about this relatively unknown population and their self-identified need priorities...
September 2, 2016: Australian Health Review: a Publication of the Australian Hospital Association
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