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https://www.readbyqxmd.com/read/29778390/next-generation-sequencing-reveals-differentially-expressed-small-noncoding-rnas-in-uterine-leiomyoma
#1
Tsai-Der Chuang, Yeming Xie, Wei Yan, Omid Khorram
OBJECTIVE: To determine the expression profile of small noncoding RNAs (sncRNAs) in leiomyoma, which has not been investigated to date. DESIGN: Laboratory-based investigation. SETTING: Academic center. PATIENT(S): Women undergoing hysterectomy for benign indications. INTERVENTION(S): Next-generation sequencing and screening of an sncRNA database with confirmatory analysis by quantitative reverse-transcription polymerase chain reaction (qRT-PCR)...
May 2018: Fertility and Sterility
https://www.readbyqxmd.com/read/29731242/therapeutic-effects-of-the-allosteric-protein-tyrosine-phosphatase-1b-inhibitor-ky-226-on-experimental-diabetes-and-obesity-via-enhancements-in-insulin-and-leptin-signaling-in-mice
#2
Yuma Ito, Masaki Fukui, Mamoru Kanda, Ko Morishita, Yoshimichi Shoji, Tatsuya Kitao, Eiichi Hinoi, Hiroaki Shirahase
The anti-diabetic and anti-obesity effects of the allosteric protein tyrosine phosphatase 1B (PTP1B) inhibitor 4-(biphenyl-4-ylmethylsulfanylmethyl)-N-(hexane-1-sulfonyl)benzoylamide (KY-226) were pharmacologically evaluated. KY-226 inhibited human PTP1B activity (IC50  = 0.28 μM), but did not exhibit peroxisome proliferator-activated receptor γ (PPARγ) agonist activity. In rodent preadipocytes (3T3-L1), KY-226 up to 10 μM had no effects on adipocyte differentiation, whereas pioglitazone, a PPARγ agonist, markedly promoted it...
March 6, 2018: Journal of Pharmacological Sciences
https://www.readbyqxmd.com/read/29709706/argirein-alleviates-vascular-endothelial-insulin-resistance-through-suppressing-the-activation-of-nox4-dependent-o-2-production-in-diabetic-rats
#3
Qing Li, Jie Su, Shi-Jie Jin, Wei Wei, Xiao-Dong Cong, Xiao-Xue Li, Ming Xu
BACKGROUND: Insulin resistance in endothelial cells contributes to the development of cardiovascular disease in type 2 diabetes mellitus (T2DM). Therefore, there are great potential clinical implications in developing pharmacological interventions targeting endothelial insulin resistance. Our previous studies indicated that argirein which was developed by combining rhein with L-arginine by a hydrogen bond, could substantially relieved stress related exacerbation of cardiac failure and alleviated cardiac dysfunction in T2DM, which was associated with suppressing NADPH oxidase activity...
April 27, 2018: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29694108/terahertz-pulse-generation-in-underdense-relativistic-plasmas-from-photoionization-induced-radiation-to-coherent-transition-radiation
#4
J Déchard, A Debayle, X Davoine, L Gremillet, L Bergé
Terahertz to far-infrared emission by two-color, ultrashort optical pulses interacting with underdense helium gases at ultrahigh intensities (>10^{19}  W/cm^{2}) is investigated by means of 3D particle-in-cell simulations. The terahertz field is shown to be produced by two mechanisms occurring sequentially, namely, photoionization-induced radiation (PIR) by the two-color pulse, and coherent transition radiation (CTR) by the wakefield-accelerated electrons escaping the plasma. We exhibit laser-plasma parameters for which CTR proves to be the dominant process, providing terahertz bursts with field strength as high as 100  GV/m and energy in excess of 10 mJ...
April 6, 2018: Physical Review Letters
https://www.readbyqxmd.com/read/29671387/positioning-europe-for-the-epitranscriptomics-challenge
#5
Michael Jantsch, Alessandro Quattrone, Mary O'Connell, Mark Helm, Michaela Frye, Manuel Macias-Gonzales, Marie Ohman, Stefan Ameres, Luc Willems, Francois Fuks, Anastasis Oulas, Stepanka Vanacova, Henrik Nielsen, Cecile Bousquet-Antonelli, Yuri Motorin, Jean-Yves Roignant, Nikolaos Balatsos, Andras Dinnyes, Pavel Baranov, Vincent Kelly, Ayelet Lamm, Gideon Rechavi, Mattia Pelizzola, Janis Liepins, Irina Holodnuka Kholodnyuk, Vanessa Zammit, Duncan Ayers, Finn Drablos, John Arne Dahl, Janusz Bujnicki, Carmen Jeronimo, Raquel Almeida, Monica Neagu, Marieta Costache, Jasna Bankovic, Bojana Banovic, Jan Kyselovic, Luis Miguel Valor, Stefan Selbert, Pinar Pir, Turan Demircan, Victoria Cowling, Matthias Schäfer, Walter Rossmanith, Denis Lafontaine, Alexandre David, Clement Carre, Frank Lyko, Raffael Schaffrath, Schraga Schwartz, Andre Verdel, Arne Klungland, Elzbieta Purta, Gordana Timotijevic, Fernando Cardona, Alberto Davalos, Ester Ballana, Donal O Carroll, Jernej Ule, Rupert Fray
The genetic alphabet consists of the four letters: C, A, G, and T in DNA and C,A,G, and U in RNA. Triplets of these four letters jointly encode 20 different amino acids out of which proteins of all organisms are built. This system is universal and is found in all kingdoms of life. However, bases in DNA and RNA can be chemically modified. In DNA, around 10 different modifications are known, and those have been studied intensively over the past 20 years. Scientific studies on DNA modifications and proteins that recognize them gave rise to the large field of epigenetic and epigenomic research...
April 19, 2018: RNA Biology
https://www.readbyqxmd.com/read/29664527/-perioperative-nutrition-in-eras-protocols
#6
Andrés Sánchez C, Karin Papapietro V
The trauma involved in any surgical procedure, even if elective, causes a metabolic stress response characterized by postoperative insulin resistance (PIR). PIR is considered a surgical stress marker and is associated with increased morbidity and postoperative length of stay. PIR worsens when the patient is operated in a state of prolonged preoperative fasting or when postoperative feeding is delayed. The ERAS Protocols (Enhanced Recovery After Surgery) includes anesthetic, surgical, kinesiology, nutritional and nursing interventions aimed to modulate PIR...
November 2017: Revista Médica de Chile
https://www.readbyqxmd.com/read/29627613/synthesis-spectral-dft-modeling-cytotoxicity-and-microbial-studies-of-novel-zr-iv-ce-iv-and-u-vi-piroxicam-complexes
#7
Walaa H El-Shwiniy, Wael A Zordok
The Zr(IV), Ce(IV) and U(VI) piroxicam anti-inflammatory drug complexes were prepared and characterized using elemental analyses, conductance, IR, UV-Vis, magnetic moment,I HNMR and thermal analysis. The ratio of metal: Pir is found to be 1:2 in all complexes estimated by using molar ratio method. The conductance data reveal that Zr(IV) and U(VI) chelates are non-electrolytes except Ce(IV) complex is electrolyte. Infrared spectroscopic confirm that the Pir behaves as a bidentate ligand co-ordinated to the metal ions via the oxygen and nitrogen atoms of ν(CO)carbonyl and ν(CN)pyridyl , respectively...
March 29, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29623647/the-association-between-serum-copper-concentrations-and-cardiovascular-disease-risk-factors-in-children-and-adolescents-in-nhanes
#8
Xiaodong Zang, Hesuyuan Huang, Zhulun Zhuang, Runsen Chen, Zongyun Xie, Cheng Xu, Xuming Mo
Copper is an essential element in human beings, alterations in serum copper levels could potentially have effect on human health. To date, no data are available regarding how serum copper affects cardiovascular disease (CVD) risk factors in children and adolescents. We examined the association between serum copper levels and CVD risk factors in children and adolescents. We analyzed data consisting of 1427 subjects from a nationally representative sample of the US population in the National Health and Nutrition Examination Survey (NHANES) from 2011 to 2014...
April 6, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29622060/partners-in-recovery-paving-the-way-for-the-national-disability-insurance-scheme
#9
Victoria Stewart, Maddy Slattery, Helena Roennfeldt, Amanda J Wheeler
Australians experiencing severe and persistent mental illness and who require services from multiple agencies, experience a fragmented service delivery system. In 2014, the Commonwealth Government introduced the Partners in Recovery (PIR) service, which provides service coordination and flexible funding to improve outcomes for this group of people. This study presents qualitative findings from a research project that aimed to understand the experiences of PIR participants, including aspects of the planning process and the effectiveness of the PIR program in meeting their needs from the perspective of the participant, their carer or family member and other support people within their lives...
April 6, 2018: Australian Journal of Primary Health
https://www.readbyqxmd.com/read/29622024/longitudinal-associations-of-long-term-exposure-to-ultrafine-particles-with-blood-pressure-and-systemic-inflammation-in-puerto-rican-adults
#10
Laura Corlin, Mark Woodin, Jaime E Hart, Matthew C Simon, David M Gute, Joanna Stowell, Katherine L Tucker, John L Durant, Doug Brugge
BACKGROUND: Few longitudinal studies have examined the association between ultrafine particulate matter (UFP, particles < 0.1 μm aerodynamic diameter) exposure and cardiovascular disease (CVD) risk factors. We used data from 791 adults participating in the longitudinal Boston Puerto Rican Health Study (Massachusetts, USA) between 2004 and 2015 to assess whether UFP exposure was associated with blood pressure and high sensitivity C-reactive protein (hsCRP, a biomarker of systemic inflammation)...
April 5, 2018: Environmental Health: a Global Access Science Source
https://www.readbyqxmd.com/read/29560725/physical-principles-and-extant-biology-reveal-roles-for-rna-containing-membraneless-compartments-in-origins-of-life-chemistry
#11
Raghav R Poudyal, Fatma Pir Cakmak, Christine D Keating, Philip C Bevilacqua
This Perspective focuses on RNA in biological and nonbiological compartments resulting from liquid-liquid phase separation (LLPS), with an emphasis on origins of life. In extant cells, intracellular liquid condensates, many of which are rich in RNAs and intrinsically disordered proteins, provide spatial regulation of biomolecular interactions that can result in altered gene expression. Given the diversity of biogenic and abiogenic molecules that undergo LLPS, such membraneless compartments may have also played key roles in prebiotic chemistries relevant to the origins of life...
March 21, 2018: Biochemistry
https://www.readbyqxmd.com/read/29550901/therapeutic-potential-of-pretreatment-with-allograft-sertoli-cells-transplantation-in-brain-ischemia-by-improving-oxidative-defenses
#12
Sara Milanizadeh, Karrar Najm Najaf Zuwarali, Abbas Aliaghaei, Mohammad Reza Bigdeli
Brain ischemia is one of the most common causes of death and disability worldwide, which usually happens through diminished blood supply to the tissue. Cell therapy and treatments using trophic factors are some of the new methods to protect brain cells against damage. Specific properties of Sertoli cells (SCs) make them suitable for improving neurological disorders. This study is to evaluate possible neuroprotective effects of SCs transplantation on ischemic damage. Rats were divided into three experimental groups including sham, control, and SCs-treated group...
March 17, 2018: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/29539584/an-evaluation-of-a-tailored-care-program-for-complex-and-persistent-mental-health-problems-partners-in-recovery-program
#13
Amelia Gulliver, Alyssa R Morse, Niah Wilson, Ginny Sargent, Michelle Banfield
Partners in Recovery (PIR) is a nation-wide Australian program designed to improve coordinated care for people with severe and persistent mental health problems. This study evaluated PIR's effectiveness for individual and system-level outcomes. A total of 25 PIR participants (male = 7, female = 15, not stated = 3) provided data for the evaluation of the program across six community mental health service providers in Canberra, Australia. Individual-level measures included quality of life, social inclusion, and perceptions of recovery...
June 2018: Evaluation and Program Planning
https://www.readbyqxmd.com/read/29528254/effects-of-laparascopic-hernia-repair-by-pirs-percutaneous-internal-ring-suturing-technique-on-testicular-artery-blood-supply
#14
Zenon Pogorelic
No abstract text is available yet for this article.
March 12, 2018: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://www.readbyqxmd.com/read/29508072/induction-of-pir-a-b-dcs-in-the-in-vitro-inflammatory-condition-and-their-immunoregulatory-function
#15
Fumi Matsui, Muneo Inaba, Kazushige Uchida, Akiyoshi Nishio, Toshiro Fukui, Hideaki Yoshimura, Atsushi Satake, Kazuhiko Yoshioka, Shosaku Nomura, Kazuichi Okazaki
BACKGROUND: Dendritic cells (DCs), primary antigen-presenting cells, are now well known as an immunoregulator of many aspects of immune responses including inflammatory bowel diseases (IBDs) such as Crohn's disease and ulcerative colitis. We have reported that PIR-A/Bhigh cDCs (conventional DCs) appeared in dextran sodium sulfate (DSS)-induced colitis and serve as a negative immunoregulator in an animal model of IBD. The immunoregulatory role of PIR-A/B+ cDCs was confirmed in both an in vitro culture system and an in vivo transfer experiment...
March 5, 2018: Journal of Gastroenterology
https://www.readbyqxmd.com/read/29499952/piwil1-pirna-dq593109-regulates-the-permeability-of-the-blood-tumor-barrier-via-the-meg3-mir-330-5p-runx3-axis
#16
Shuyuan Shen, Hai Yu, Xiaobai Liu, Yunhui Liu, Jian Zheng, Ping Wang, Wei Gong, Jiajia Chen, Lini Zhao, Yixue Xue
The blood-tumor barrier (BTB) restricts the efficient delivery of anti-glioma drugs to cranial glioma tissues. Increased BTB permeability may allow greater delivery of the therapeutic agents. Increasing evidence has revealed that PIWI proteins and PIWI-interacting RNAs (piRNAs) play an important role in tumor progression. However, whether PIWI proteins and piRNAs regulate BTB permeability remains unclear. In the present study, we demonstrated that the PIWIL1/piRNA-DQ593109 (piR-DQ593109) complex was the predominant regulator of BTB permeability...
March 2, 2018: Molecular Therapy. Nucleic Acids
https://www.readbyqxmd.com/read/29492093/un-ruptured-non-coronary-sinus-of-valsalva-aneurysm-with-complete-heart-block
#17
Saba Hussain, Faisal Qadir, Pir Sheeraz, M Asad Bilal Awan
Sinus of Valsalva aneurysm is a rare cardiac anomaly with wide spectrum of clinical presentation ranging from asymptomatic state to dreadful complications due to compression of vital surrounding structures or aortic dissection. There are only few reported cases of sinus of Valsalva aneurysm presented with cardiac arrhythmias including complete heart block. We herein, present a case of a 50 year male who presented with complete heart block. A large noncoronary sinus of Valsalva aneurysm compressing the surrounding atrioventricular junctional tissue was detected incidentally during echocardiographic study, which was considered to be the cause of patient's complete heart block...
November 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/29464001/piwil3-oip5-as1-mir-367-3p-cebpa-feedback-loop-regulates-the-biological-behavior-of-glioma-cells
#18
Xiaobai Liu, Jian Zheng, Yixue Xue, Hai Yu, Wei Gong, Ping Wang, Zhen Li, Yunhui Liu
Rationale: PIWI-interacting RNAs (piRNAs), a class of newly discovered small RNA molecules that function by binding to the Argonaute protein family (i.e., the PIWIL protein subfamily), and long noncoding RNAs (lncRNA) are implicated in several cancers. However, the detailed roles of ncRNAs in glioma remain unclear. Methods: The expression of PIWIL3, piR-30188, OIP5-AS1, miR-367, CEBPA and TRAF4 were measured in glioma tissues and cells. The role of PIWIL3/OIP5-AS1/miR-367-3p/CEBPA feedback loop was evaluated in cell and animal models...
2018: Theranostics
https://www.readbyqxmd.com/read/29462908/research-on-the-multiple-factors-influencing-human-identification-based-on-pyroelectric-infrared-sensors
#19
Junwei Yan, Ping Lou, Ruiya Li, Jianmin Hu, Ji Xiong
Analysis of the multiple factors affecting human identification ability based on pyroelectric infrared technology is a complex problem. First, we examine various sensed pyroelectric waveforms of the human body thermal infrared signal and reveal a mechanism for affecting human identification. Then, we find that the mechanism is decided by the distance, human target, pyroelectric infrared (PIR) sensor, the body type, human moving velocity, signal modulation mask, and Fresnel lens. The mapping relationship between the sensed waveform and multiple influencing factors is established, and a group of mathematical models are deduced which fuse the macro factors and micro factors...
February 16, 2018: Sensors
https://www.readbyqxmd.com/read/29460056/testicular-pirna-profile-comparison-between-successful-and-unsuccessful-micro-tese-retrieval-in-noa-patients
#20
Congcong Cao, Yujiao Wen, Xiaoli Wang, Na Fang, Shuiqiao Yuan, Xunbin Huang
PURPOSE: PIWI-interacting RNA (piRNA) is a sub-group of small RNAs about 30 nucleotides length which specifically expressed in mammalian germ cells. Although piRNAs play pivotal roles in spermatogenesis regulation, little is known in the testicular tissues of infertile men. To explore whether piRNA profile could serve as a biomarker for male infertility diagnosis in a clinic, in this study, we systematically investigated the expression profile of piRNAs in testicular tissues from the patients with non-obstructive azoospermia (NOA) between successful and unsuccessful sperm retrieval before micro-dissection testicular sperm extraction (micro-TESE)...
February 19, 2018: Journal of Assisted Reproduction and Genetics
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