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https://www.readbyqxmd.com/read/28077829/-development-of-a-psychological-insulin-resistance-scale-for-korean-patients-with-diabetes
#1
Youngshin Song, Younghee Jeon, Jeonghwa Cho, Bohyun Kim
PURPOSE: This study was done to develop and validate a measure to evaluate the Korean version of psychological insulin resistance (K-PIR) in patients with diabetes in Korea. METHODS: Items were initially generated from literature reviews and interviews with 19 patients with diabetes. The content validity of the items was evaluated by experts. Participants were 424 patients with diabetes recruited through convenience sampling. A cross-sectional survey was designed for item-analysis, exploratory factor analysis with principal axis factoring, and confirmatory factor analysis...
December 2016: Journal of Korean Academy of Nursing
https://www.readbyqxmd.com/read/28076968/influence-of-southwest-monsoons-in-the-kashmir-valley-western-himalayas
#2
Ghulam Jeelani, Rajendrakumar D Deshpande, Rouf A Shah, Wasim Hassan
The regional climate of the Himalayas is predominated by the southwest monsoons and the western disturbances. The uplift of the Pir Panjal to its present height is believed to restrict the southwest monsoons from entering into the Kashmir Valley in the western Himalayas. In the present study, monthly precipitation samples were collected across the Kashmir Valley from June 2013 to May 2014 for δ(18)O and δ(2)H analyses to constrain the influence of southwest monsoons in the valley. Except in August, the precipitation is enriched in (18)O and (2)H from June to September and depleted from October to May...
January 12, 2017: Isotopes in Environmental and Health Studies
https://www.readbyqxmd.com/read/28050022/an-isolate-of-vibrio-campbellii-carrying-the-pir-vp-gene-causes-acute-hepatopancreatic-necrosis-disease
#3
Xuan Dong, Hailiang Wang, Guosi Xie, Peizhuo Zou, Chengcheng Guo, Yan Liang, Jie Huang
No abstract text is available yet for this article.
January 4, 2017: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/28042769/discovery-of-an-unexplored-protein-structural-scaffold-of-serine-protease-from-big-blue-octopus-octopus-cyanea-a-new-prospective-lead-molecule
#4
Subhamay Panda, Leena Kumari
BACKGROUND: Serine proteases are a group of enzymes that hydrolyses the peptide bonds in proteins. In mammals, these enzymes help in the regulation of several major physiological functions such as digestion, blood clotting, responses of immune system, reproductive functions and the complement system. OBJECTIVE: Serine proteases obtained from the venom of Octopodidae family is a relatively unexplored area of research. In the present work, we tried to effectively utilize comparative composite molecular modeling technique...
January 2, 2017: Current Drug Discovery Technologies
https://www.readbyqxmd.com/read/28008421/a-new-plasmodium-vivax-reference-sequence-with-improved-assembly-of-the-subtelomeres-reveals-an-abundance-of-pir-genes
#5
Sarah Auburn, Ulrike Böhme, Sascha Steinbiss, Hidayat Trimarsanto, Jessica Hostetler, Mandy Sanders, Qi Gao, Francois Nosten, Chris I Newbold, Matthew Berriman, Ric N Price, Thomas D Otto
Plasmodium vivax is now the predominant cause of malaria in the Asia-Pacific, South America and Horn of Africa. Laboratory studies of this species are constrained by the inability to maintain the parasite in continuous ex vivo culture, but genomic approaches provide an alternative and complementary avenue to investigate the parasite's biology and epidemiology. To date, molecular studies of P. vivax have relied on the Salvador-I reference genome sequence, derived from a monkey-adapted strain from South America...
November 15, 2016: Wellcome Open Res
https://www.readbyqxmd.com/read/28006879/microbiological-characteristics-of-perianal-streptococcal-dermatitis-a-retrospective-study-of-105-patients-in-a-10-year-period
#6
Anja Šterbenc, Katja Seme, Liza Lea Lah, Olga Točkova, Tina Kamhi Trop, Nataša Švent-Kučina, Mateja Pirš
Beta-hemolytic streptococci (BHS) are the most common causative agents of perianal streptococcal dermatitis (PSD). This study evaluates the distribution of BHS isolates in perianal bacterial cultures. We retrospectively reviewed microbiological results for perianal BHS that were isolated in our laboratory between 2006 and 2015. We identified a total of 105 BHS isolates from rectal swabs and swabs of clinically intact perianal skin. The majority of BHS were of group A (GABHS) (73/105; 69.5%), followed by group B BHS (GBBHS) (27/105; 25...
December 2016: Acta Dermatovenerologica Alpina, Panonica, et Adriatica
https://www.readbyqxmd.com/read/27976750/compass-continuous-open-mouse-phenotyping-of-activity-and-sleep-status
#7
Laurence A Brown, Sibah Hasan, Russell G Foster, Stuart N Peirson
Background  Disruption of rhythms in activity and rest occur in many diseases, and provide an important indicator of healthy physiology and behaviour. However, outside the field of sleep and circadian rhythm research, these rhythmic processes are rarely measured due to the requirement for specialised resources and expertise. Until recently, the primary approach to measuring activity in laboratory rodents has been based on voluntary running wheel activity. By contrast, measuring sleep requires the use of electroencephalography (EEG), which involves invasive surgical procedures and time-consuming data analysis...
2016: Wellcome Open Res
https://www.readbyqxmd.com/read/27965112/proteolytic-processing-of-the-saccharomyces-cerevisiae-cell-wall-protein-scw4-regulates-its-activity-and-influences-its-covalent-binding-to-glucan
#8
Antonija Grbavac, Iva Čanak, Igor Stuparević, Renata Teparić, Vladimir Mrša
Yeast cell wall contains a number of proteins that are either non-covalently (Scw-proteins), or covalently (Ccw-proteins) bound to β-1,3-glucan, the latter either through GPI-anchors and β-1,6-glucan, or by alkali labile ester linkages between γ-carboxyl groups of glutamic acid and hydroxyl groups of glucoses (Pir-proteins). It was shown that a part of Scw4, previously identified among the non-covalently bound cell wall proteins, was covalently attached to wall polysaccharides by a so far unknown alkali sensitive linkage...
December 10, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27919963/expression-levels-of-piwi-interacting-rna-pir-823-are-deregulated-in-tumor-tissue-blood-serum-and-urine-of-patients-with-renal-cell-carcinoma
#9
Robert Iliev, Michal Fedorko, Tana Machackova, Hana Mlcochova, Marek Svoboda, Dalibor Pacik, Jan Dolezel, Michal Stanik, Ondrej Slaby
BACKGROUND: Renal cell carcinoma (RCC) is the most common neoplasm of adult kidney accounting for about 3% of adult malignancies. P-Element induced wimpy testis (PIWI)-interacting RNAs (piRNAs) are a new class of naturally occurring, short non-coding RNAs involved in silencing of transposable elements and in sequence-specific chromatin modifications. There were preliminary data published indicating that piR-823 expression is deregulated in circulating tumor cells and tumor tissue in gastric and kidney cancer, respectively...
2016: Anticancer Research
https://www.readbyqxmd.com/read/27916906/enabling-smart-air-conditioning-by-sensor-development-a-review
#10
REVIEW
Chin-Chi Cheng, Dasheng Lee
The study investigates the development of sensors, in particular the use of thermo-fluidic sensors and occupancy detectors, to achieve smart operation of air conditioning systems. Smart operation refers to the operation of air conditioners by the reinforcement of interaction to achieve both thermal comfort and energy efficiency. Sensors related to thermal comfort include those of temperature, humidity, and pressure and wind velocity anemometers. Improvements in their performance in the past years have been studied by a literature survey...
November 30, 2016: Sensors
https://www.readbyqxmd.com/read/27884144/assessment-of-serology-and-spirometry-and-the-combination-of-both-to-complement-microbiological-isolation-for-earlier-detection-of-pseudomonas-aeruginosa-infection-in-children-with-cystic-fibrosis
#11
Ana Kotnik Pirš, Uroš Krivec, Saša Simčič, Katja Seme
BACKGROUND: The aim of this study was to assess whether serology and spirometry and the combination of both can complement culture-based detection for earlier recognition of Pseudomonas aeruginosa infection in children with cystic fibrosis. METHODS: A 4 year longitudinal prospective study that included 67 Slovenian children with cystic fibrosis with a mean age of 10.5 years was conducted. Serology, spirometry and a scoring system combining serology and spirometry were assessed and compared...
November 25, 2016: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/27865134/polychromatic-light-480-3400nm-similar-to-the-terrestrial-solar-spectrum-without-its-uv-component-in-post-surgical-immunorehabilitation-of-breast-cancer-patients
#12
Natalia A Zhevago, Alexander A Zimin, Tatyana V Glazanova, Natalia I Davydova, Natalia V Bychkova, Zhanna V Chubukina, Anna I Buinyakova, Marina F Ballyuzek, Kira A Samoilova
To this day, two methods of phototherapy (PT) have been successfully used in post-surgical immunorehabilitation of patients with breast cancer (BC): intravenous laser irradiation of the patients' blood and reinfusion of lympholeukosuspension of BC patients after single irradiation with HeNe laser. The objective of this pilot experimental study was to verify the effectiveness of the percutaneous use of polychromatic visible light combined with polychromatic infrared (pVIS+pIR) radiation similar to the major components of natural solar spectrum in post-surgical management of BC patients...
January 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/27851824/variant-exported-blood-stage-proteins-encoded-by-plasmodium-multigene-families-are-expressed-in-liver-stages-where-they-are-exported-into-the-parasitophorous-vacuole
#13
Aurélie Fougère, Andrew P Jackson, Dafni Paraskevi Bechtsi, Joanna A M Braks, Takeshi Annoura, Jannik Fonager, Roberta Spaccapelo, Jai Ramesar, Séverine Chevalley-Maurel, Onny Klop, Annelies M A van der Laan, Hans J Tanke, Clemens H M Kocken, Erica M Pasini, Shahid M Khan, Ulrike Böhme, Christiaan van Ooij, Thomas D Otto, Chris J Janse, Blandine Franke-Fayard
Many variant proteins encoded by Plasmodium-specific multigene families are exported into red blood cells (RBC). P. falciparum-specific variant proteins encoded by the var, stevor and rifin multigene families are exported onto the surface of infected red blood cells (iRBC) and mediate interactions between iRBC and host cells resulting in tissue sequestration and rosetting. However, the precise function of most other Plasmodium multigene families encoding exported proteins is unknown. To understand the role of RBC-exported proteins of rodent malaria parasites (RMP) we analysed the expression and cellular location by fluorescent-tagging of members of the pir, fam-a and fam-b multigene families...
2016: PLoS Pathogens
https://www.readbyqxmd.com/read/27832656/perifocal-inflammatory-reaction-with-volume-fluctuation-caused-by-diagnostic-radiation-induced-regression-in-germinoma-makes-histological-diagnosis-difficult-despite-its-disappearance-following-treatment-a-significant-pitfall-and-countermeasures-to-it
#14
Yuichiro Yoneoka, Junichi Yoshimura, Masayasu Okada, Yukihiko Fujii
We present a pediatric case of neurohypophyseal germinoma with a perifocal inflammatory reaction (PIR) with volume fluctuation caused by diagnostic radiation-induced regression (DRIR). On-target biopsy failed to confirm the histology because PIR hardly contained any germinoma cells. DRIR-related fluctuation of the tumor volume disguised germinoma as inflammation. We analyzed the cerebrospinal fluid (CSF) and detected a high level of placental alkaline phosphatase (PLAP), which demonstrated the neurohypophyseal lesion to be germinoma and brought the patient from successful radiochemotherapy up to complete remission...
November 11, 2016: Pediatric Neurosurgery
https://www.readbyqxmd.com/read/27830199/qualitative-evaluation-of-anterior-segment-in-angle-closure-disease-using-anterior-segment-optical-coherence-tomography
#15
Sasan Moghimi, Rebecca Chen, Nikoo Hamzeh, Nassim Khatibi, Shan C Lin
PURPOSE: To evaluate different mechanisms of primary angle closure (PAC) and to quantify anterior chamber (AC) parameters in different subtypes of angle closure disease using anterior segment optical coherence tomography (AS-OCT). METHODS: In this prospective study, 115 eyes of 115 patients with angle closure disease were included and categorized into three groups: 1) fellow eyes of acute angle closure (AAC; 40 eyes); 2) primary angle closure glaucoma (PACG; 39 eyes); and 3) primary angle closure suspect (PACS; 36 eyes)...
December 2016: Journal of Current Ophthalmology
https://www.readbyqxmd.com/read/27828022/frequency-domain-phase-noise-analysis-of-dual-injection-locked-optoelectronic-oscillators
#16
Sajad Jahanbakht
Dual injection-locked optoelectronic oscillators (DIL-OEOs) have been introduced as a means to achieve very low-noise microwave oscillations while avoiding the large spurious peaks that occur in the phase noise of the conventional single-loop OEOs. In these systems, two OEOs are inter-injection locked to each other. The OEO with the longer optical fiber delay line is called the master OEO, and the other is called the slave OEO. Here, a frequency domain approach for simulating the phase noise spectrum of each of the OEOs in a DIL-OEO system and based on the conversion matrix approach is presented...
October 1, 2016: Applied Optics
https://www.readbyqxmd.com/read/27798849/dusp11-activity-on-triphosphorylated-transcripts-promotes-argonaute-association-with-noncanonical-viral-micrornas-and-regulates-steady-state-levels-of-cellular-noncoding-rnas
#17
James M Burke, Rodney P Kincaid, Ryan M Nottingham, Alan M Lambowitz, Christopher S Sullivan
RNA silencing is a conserved eukaryotic gene expression regulatory mechanism mediated by small RNAs. In Caenorhabditis elegans, the accumulation of a distinct class of siRNAs synthesized by an RNA-dependent RNA polymerase (RdRP) requires the PIR-1 phosphatase. However, the function of PIR-1 in RNAi has remained unclear. Since mammals lack an analogous siRNA biogenesis pathway, an RNA silencing role for the mammalian PIR-1 homolog (dual specificity phosphatase 11 [DUSP11]) was unexpected. Here, we show that the RNA triphosphatase activity of DUSP11 promotes the RNA silencing activity of viral microRNAs (miRNAs) derived from RNA polymerase III (RNAP III) transcribed precursors...
September 15, 2016: Genes & Development
https://www.readbyqxmd.com/read/27782828/spatial-transcriptome-analysis-reveals-notch-pathway-associated-prognostic-markers-in-idh1-wild-type-glioblastoma-involving-the-subventricular-zone
#18
Christine Jungk, Andreas Mock, Janina Exner, Christoph Geisenberger, Rolf Warta, David Capper, Amir Abdollahi, Sara Friauf, Bernd Lahrmann, Niels Grabe, Philipp Beckhove, Andreas von Deimling, Andreas Unterberg, Christel Herold-Mende
BACKGROUND: The spatial relationship of glioblastoma (GBM) to the subventricular zone (SVZ) is associated with inferior patient survival. However, the underlying molecular phenotype is largely unknown. We interrogated an SVZ-dependent transcriptome and potential location-specific prognostic markers. METHODS: mRNA microarray data of a discovery set (n = 36 GBMs) were analyzed for SVZ-dependent gene expression and process networks using the MetaCore™ workflow...
October 26, 2016: BMC Medicine
https://www.readbyqxmd.com/read/27740454/cyclin-kinase-independent-role-of-p21-cdkn1a-in-the-promotion-of-nascent-dna-elongation-in-unstressed-cells
#19
Sabrina F Mansilla, Agustina P Bertolin, Valérie Bergoglio, Marie-Jeanne Pillaire, Marina A González Besteiro, Carlos Luzzani, Santiago G Miriuka, Christophe Cazaux, Jean-Sébastien Hoffmann, Vanesa Gottifredi
The levels of the cyclin-dependent kinase (CDK) inhibitor p21 are low in S phase and insufficient to inhibit CDKs. We show here that endogenous p21, instead of being residual, it is functional and necessary to preserve the genomic stability of unstressed cells. p21depletion slows down nascent DNA elongation, triggers permanent replication defects and promotes the instability of hard-to-replicate genomic regions, namely common fragile sites (CFS). The p21's PCNA interacting region (PIR), and not its CDK binding domain, is needed to prevent the replication defects and the genomic instability caused by p21 depletion...
October 14, 2016: ELife
https://www.readbyqxmd.com/read/27730514/intranasal-insulin-administration-ameliorates-streptozotocin-icv-induced-insulin-receptor-dysfunction-neuroinflammation-amyloidogenesis-and-memory-impairment-in-rats
#20
N Rajasekar, Chandishwar Nath, Kashif Hanif, Rakesh Shukla
Alzheimer's disease (AD) is associated with reduced insulin level and impairment of insulin receptor (IR) signaling in the brain, which correlates to amyloid pathology, neuroinflammation, and synaptic neurotoxicity. Clinical studies show that intranasal insulin improves memory in AD patients without peripheral hypoglycemia. However, neuroprotective molecular mechanism of the beneficial effect of intranasal insulin in AD pathology is unexplored. Therefore, we investigated the role of intranasal insulin on intracerebroventricular (ICV) streptozotocin (STZ)-induced memory impairment in rats as evaluated in the Morris water maze test...
October 11, 2016: Molecular Neurobiology
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