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https://www.readbyqxmd.com/read/28928791/wu-mei-wan-reduces-insulin-resistance-via-inhibition-of-nlrp3-inflammasome-activation-in-hepg2-cells
#1
Xueping Yang, Lingli Li, Ke Fang, Ruolan Dong, Jingbin Li, Yan Zhao, Hui Dong, Ping Yi, Zhaoyi Huang, Guang Chen, Fuer Lu
Wu-Mei-Wan (WMW) is a Chinese herbal formula used to treat type 2 diabetes. In this study, we aimed to explore the effects and mechanisms of WMW on insulin resistance in HepG2 cells. HepG2 cells were pretreated with palmitate (0.25 mM) to impair the insulin signaling pathway. Then, they were treated with different doses of WMW-containing medicated serum and stimulated with 100 nM insulin. Results showed that palmitate could reduce the glucose consumption rate in HepG2 cells and impair insulin signaling related to phosphorylation of insulin receptor (IR) and insulin receptor substrate-1 (IRS-1), thereby regulating the downstream signaling pathways...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28912525/pulse-transit-time-based-continuous-cuffless-blood-pressure-estimation-a-new-extension-and-a-comprehensive-evaluation
#2
Xiaorong Ding, Bryan P Yan, Yuan-Ting Zhang, Jing Liu, Ni Zhao, Hon Ki Tsang
Cuffless technique enables continuous blood pressure (BP) measurement in an unobtrusive manner, and thus has the potential to revolutionize the conventional cuff-based approaches. This study extends the pulse transit time (PTT) based cuffless BP measurement method by introducing a new indicator - the photoplethysmogram (PPG) intensity ratio (PIR). The performance of the models with PTT and PIR was comprehensively evaluated in comparison with six models that are based on sole PTT. The validation conducted on 33 subjects with and without hypertension, at rest and under various maneuvers with induced BP changes, and over an extended calibration interval, respectively...
September 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28912059/piracetam-inhibits-ethanol-etoh-induced-memory-deficit-by-mediating-multiple-pathways
#3
Yifan Yang, Jian Feng, Fangyuan Xu, Jianglin Wang
Excessive ethanol (EtOH) intake, especially to prenatal exposure, can significantly affect cognitive function and cause permanent learning and memory injures in children. As a result, how to protect children from EtOH neurotoxicity has gained increasing attention in recent years. Piracetam (Pir) is a nootropic drug derived from c-aminobutyric acid and can manage cognition impairments in multiple neurological disorders. Studies have shown that Pir can exert therapeutic effects on EtOH-induced memory impairments, but the underlying mechanism is still unknown...
September 11, 2017: Brain Research
https://www.readbyqxmd.com/read/28911802/transient-gestational-exposure-to-drinking-water-containing-excess-hexavalent-chromium-modifies-insulin-signaling-in-liver-and-skeletal-muscle-of-rat-progeny
#4
Navaneethabalakrishnan Shobana, Mariajoseph Michael Aruldhas, Lalmuankimi Tochhawng, Ayyalu Loganathan, Sadhasivam Balaji, Mani Kathiresh Kumar, Liaquat Alikhan Sheerin Banu, Ajit Kumar Navin, Chinnaiyan Mayilvanan, Ramachandran Ilangovan, Karundevi Balasubramanian
Chromium (Cr), an essential micronutrient potentiates insulin action, whereas excess hexavalent Cr (CrVI) acts as an endocrine disruptor. Pregnant mothers living in areas abutting industries using the metal and chromite ore dumps are exposed to ground water contaminated with Cr. Nevertheless, the impact of prenatal exposure to excess CrVI on insulin signaling in the progeny remains obscure. We tested the hypothesis "transient gestational exposure to drinking water containing excess CrVI may modify insulin signaling during postnatal life"...
September 11, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28898976/regulation-of-immune-and-neural-function-via-leukocyte-ig-like-receptors
#5
Kazuya Takeda, Akira Nakamura
Leukocyte Ig-like receptors (LILRs)/Ig-like transcripts (ILTs) are expressed on innate and adaptive immune cells and maintain immune homeostasis. LILRs consist of activating and inhibitory-type receptors that regulate adequate cellular functions. LILRs were firstly identified as MHC class I receptors, therefore expression and/or polymorphisms of LILRs are reported to associate with autoimmune disorders and transplant rejection; however, recent accumulating evidences have revealed that LILRs recognize with diverse ligands including bacteria and virus...
August 1, 2017: Journal of Biochemistry
https://www.readbyqxmd.com/read/28889942/differential-functions-of-wave-regulatory-complex-subunits-in-the-regulation-of-actin-driven-processes
#6
Christof Litschko, Joern Linkner, Stefan Brühmann, Theresia E B Stradal, Tobias Reinl, Lothar Jänsch, Klemens Rottner, Jan Faix
The WAVE regulatory complex (WRC) links upstream Rho-family GTPase signaling to the activation of the ARP2/3 complex in different organisms. WRC-induced and ARP2/3 complex-mediated actin nucleation beneath the plasma membrane is critical for actin assembly in the leading edge to drive efficient cell migration. The WRC is a stable heteropentamer composed of SCAR/WAVE, Abi, Nap, Pir and the small polypeptide Brk1/Hspc300. Functional interference with individual subunits of the complex frequently results in diminished amounts of the remaining polypeptides of the WRC complex, implying the complex to act as molecular entity...
September 4, 2017: European Journal of Cell Biology
https://www.readbyqxmd.com/read/28886077/exploration-of-ethno-medicinal-knowledge-among-rural-communities-of-pearl-valley-rawalakot-district-poonch-azad-jammu-and-kashmir
#7
Humaira Shaheen, Mirza Faisal Qaseem, Muhammad Shoaib Amjad, Piero Bruschi
BACKGROUND: Medicinal plants are the basic source of health care in the Pearl Valley District Poonch, Azad Jammu, and Kashmir. The basic aim of present study was to record information about the use of plants in herbal preparation and quantification of recorded data. MATERIALS AND METHODS: The research was conducted with the null hypothesis that there was no differential distribution of knowledge among the communities between genders and among different age groups in the study area and across cultural medicinal uses of the plants are similar...
2017: PloS One
https://www.readbyqxmd.com/read/28875854/cytomegalovirus-infection-the-neurodevelopmental-peptide-signatures
#8
Guglielmo Lucchese, Darja Kanduc
BACKGROUND AND OBJECTIVE: HCMV infection may cause neurodevelopmental disorders, including intellectual disability, hearing loss, cortical malformations, and calcifications. Theorizing about the still unknown molecular basis of HCMV-related diseases, this study analyzes the peptide sharing between HCMV, strains AD169 and Merlin, and human proteins, searching for shared sequences that might lead to crossreactive autoimmune injuries in the brain during immune responses following HCMV infection...
August 29, 2017: Current Drug Discovery Technologies
https://www.readbyqxmd.com/read/28840618/the-beneficial-effect-of-anthocyanidin-rich-vitis-vinifera-l-grape-skin-extract-on-metabolic-changes-induced-by-high-fat-diet-in-mice-involves-antiinflammatory-and-antioxidant-actions
#9
Gisele França da Costa, Izabelle Barcellos Santos, Graziele Freitas de Bem, Viviane Silva Cristino Cordeiro, Cristiane Aguiar da Costa, Lenize Costa Reis Marins de Carvalho, Dayane Teixeira Ognibene, Angela Castro Resende, Roberto Soares de Moura
We hypothesized that a polyphenol-rich extract from Vitis vinifera L. grape skin (GSE) may exert beneficial effects on obesity and related metabolic disorders induced by a high-fat diet (HFD). C57/BL6 mice were fed a standard diet (10% fat, control, and GSE groups) or an HFD (60% fat, high fat (HF), and HF + GSE) with or without GSE (200 mg/kg/day) for 12 weeks. GSE prevented weight gain; dyslipidemia; insulin resistance; the alterations in plasma levels of leptin, adiponectin, and resistin; and the deregulation of leptin and adiponectin expression in adipose tissue...
August 25, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28830705/caffeine-and-insomnia-in-people-living-with-hiv-from-the-miami-adult-studies-on-hiv-mash-cohort
#10
Venkataraghavan Ramamoorthy, Adriana Campa, Muni Rubens, Sabrina S Martinez, Christina Fleetwood, Tiffanie Stewart, Juan P Liuzzi, Florence George, Hafiz Khan, Yinghui Li, Marianna K Baum
We explored the relationship between caffeine consumption, insomnia, and HIV disease progression (CD4+ T cell counts and HIV viral loads). Caffeine intake and insomnia levels were measured using the Modified Caffeine Consumption Questionnaire and the Pittsburgh Insomnia Rating Scale (PIRS) in 130 clinically stable participants who were living with HIV, taking antiretroviral therapy, and recruited from the Miami Adult Studies on HIV cohort. Linear regressions showed that caffeine consumption was significantly and adversely associated with distress score, quality-of-life score, and global PIRS score...
July 31, 2017: Journal of the Association of Nurses in AIDS Care: JANAC
https://www.readbyqxmd.com/read/28829774/a-large-scale-plasmodium-vivax-saimiri-boliviensis-trophozoite-schizont-transition-proteome
#11
D C Anderson, Stacey A Lapp, John W Barnwell, Mary R Galinski
Plasmodium vivax is a complex protozoan parasite with over 6,500 genes and stage-specific differential expression. Much of the unique biology of this pathogen remains unknown, including how it modifies and restructures the host reticulocyte. Using a recently published P. vivax reference genome, we report the proteome from two biological replicates of infected Saimiri boliviensis host reticulocytes undergoing transition from the late trophozoite to early schizont stages. Using five database search engines, we identified a total of 2000 P...
2017: PloS One
https://www.readbyqxmd.com/read/28826361/spermatozoa-expression-of-pir-31704-pir-39888-and-pir-40349-and-their-correlation-to-sperm-concentration-and-fertilization-rate-after-icsi
#12
Long Cui, Li Fang, Biwei Shi, Sunquan Qiu, Yinghui Ye
OBJECTIVE: To investigate the relationship between spermatozoa PIWI-interacting RNAs (piRNAs) levels and semen parameters and to evaluate the role of expression of piRNAs on fertilization and embryo development after intracytoplasmic sperm injection (ICSI) treatment. METHODS: One hundred and eighty-six patients with idiopathic male infertility who had undergone first ICSI cycles were enrolled in our study. The levels of piRNAs in spermatozoa were measured by real-time polymerase chain reaction...
January 1, 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/28801942/cancer-risk-in-different-generations-of-middle-eastern-immigrants-to-california-1988-2013
#13
Clara Ziadeh, Argyrios Ziogas, Hoda Anton-Culver
The objective of this study is to compare cancer risk among different generations of Middle Eastern immigrants (ME) and non-Hispanic whites (NHW) in California between 1988 and 2013. We used data from the California Cancer Registry to identify invasive primary incident cancer cases in three population groups: (i) first-generation ME immigrants, (ii) second- or subsequent-generations ME immigrants, and (iii) NHW. Proportional incidence ratio (PIR) was used to compare cancer risk of the 15 selected most common cancers in the 3 population groups taking into consideration time since immigration for first-generation ME immigrants...
August 12, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28780849/photoelectrochemical-behavior-of-a-molecular-ru-based-water-oxidation-catalyst-bound-to-tio2-protected-si-photoanodes
#14
Roc Matheu, Ivan A Moreno-Hernandez, Xavier Sala, Harry B Gray, Bruce S Brunschwig, Antoni Llobet, Nathan S Lewis
A hybrid photoanode based on a molecular water oxidation precatalyst was prepared from TiO2-protected n- or p(+)-Si coated with multiwalled carbon nanotubes (CNT) and the ruthenium-based water oxidation precatalyst [Ru(IV)(tda)(py-pyr)2(O)], 1(O) (tda(2-) is [2,2':6',2″-terpyridine]-6,6″-dicarboxylato and py-pir is 4-(pyren-1-yl)-N-(pyridin-4-ylmethyl)butanamide). The Ru complex was immobilized by π-π stacking onto CNTs that had been deposited by drop casting onto Si electrodes coated with 60 nm of amorphous TiO2 and 20 nm of a layer of sputtered C...
August 15, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28758934/simultaneous-indoor-tracking-and-activity-recognition-using-pyroelectric-infrared-sensors
#15
Xiaomu Luo, Qiuju Guan, Huoyuan Tan, Liwen Gao, Zhengfei Wang, Xiaoyan Luo
Indoor human tracking and activity recognition are fundamental yet coherent problems for ambient assistive living. In this paper, we propose a method to address these two critical issues simultaneously. We construct a wireless sensor network (WSN), and the sensor nodes within WSN consist of pyroelectric infrared (PIR) sensor arrays. To capture the tempo-spatial information of the human target, the field of view (FOV) of each PIR sensor is modulated by masks. A modified partial filter algorithm is utilized to decode the location of the human target...
July 29, 2017: Sensors
https://www.readbyqxmd.com/read/28748222/an-improved-plasmodium-cynomolgi-genome-assembly-reveals-an-unexpected-methyltransferase-gene-expansion
#16
Erica M Pasini, Ulrike Böhme, Gavin G Rutledge, Annemarie Voorberg-Van der Wel, Mandy Sanders, Matt Berriman, Clemens Hm Kocken, Thomas Dan Otto
BACKGROUND: Plasmodium cynomolgi, a non-human primate malaria parasite species, has been an important model parasite since its discovery in 1907. Similarities in the biology of P. cynomolgi to the closely related, but less tractable, human malaria parasite P. vivax make it the model parasite of choice for liver biology and vaccine studies pertinent to P. vivax malaria. Molecular and genome-scale studies of P. cynomolgi have relied on the current reference genome sequence, which remains highly fragmented with 1,649 unassigned scaffolds and little representation of the subtelomeres...
2017: Wellcome Open Research
https://www.readbyqxmd.com/read/28733293/androgen-responsive-non-coding-small-rnas-extend-the-potential-use-of-hcg-stimulation-as-a-bioassay-of-androgen-sufficiency
#17
Martina Rodie, Manikhandan Av Mudaliar, Pawel Herzyk, M McMillan, Massoud Boroujerdi, Sandra Chudleigh, Edward S Tobias, S Faisal Ahmed
BACKGROUND: It is unclear whether a short-term change in circulating androgens is associated with changes in the transcriptome of the peripheral blood mononuclear cells (PBMC). AIMS & METHODS: To explore the effect of hCG-stimulation on the PBMC-transcriptome, 12 boys with a median age (range) of 0.7yrs (0.3, 11.2) who received intramuscular hCG 1500u on 3 consecutive days as part of their investigations underwent transcriptomic array analysis on RNA extracted from peripheral blood mononuclear cells before and after hCG stimulation...
July 21, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28726269/previous-physical-exercise-alters-the-hepatic-profile-of-oxidative-inflammatory-status-and-limits-the-secondary-brain-damage-induced-by-severe-traumatic-brain-injury-in-rats
#18
Mauro Robson Torres de Castro, Ana Paula de Oliveira Ferreira, Guilherme Lago Busanello, Luís Roberto Hart da Silva, Mauro Eduardo Porto da Silveira Junior, Fernando da Silva Fiorin, Gabriela Arrifano, Maria Elena Crespo-López, Rômulo Pillon Barcelos, María J Cuevas, Guilherme Bresciani, Javier González-Gallego, Michele Rechia Fighera, Luiz Fernando Freire Royes
KEY POINTS: An early inflammatory response and oxidative stress are implicated in the signal transduction that alters both hepatic redox status and mitochondrial function after traumatic brain injury (TBI). Peripheral oxidative/inflammatory responses contribute to neuronal dysfunction after TBI Exercise training alters the profile of oxidative-inflammatory status in liver and protects against acute hyperglycaemia and a cerebral inflammatory response after TBI. Approaches such as exercise training, which attenuates neuronal damage after TBI, may have therapeutic potential through modulation of responses by metabolic organs...
September 1, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28711676/should-we-consider-fecal-colonization-with-extended-spectrum-%C3%AE-lactamase-producing-enterobacteriaceae-in-empiric-therapy-of-community-onset-sepsis
#19
Daša Stupica, Lara Lusa, Mirijam Nahtigal Klevišar, Sara Terzić, Mateja Pirš, Manica Mueller Premru, Franc Strle
In patients colonized with extended-spectrum β-lactamase-producing Enterobacteriaceae (ESBL-E), the preference for carbapenems (CRB) over non-CRB antibiotics for empiric therapy of sepsis is questionable from an ecologic perspective and also how well colonization actually predicts an ESBL-E etiology of infection has been poorly investigated. The purpose of this retrospective observational study was to determine the positive predictive value (PPV) of ESBL-E fecal colonization for ESBL-E etiology of sepsis and the impact of empiric therapy on treatment outcome...
July 12, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28710271/novel-alphacoronaviruses-and-paramyxoviruses-cocirculate-with-type-1-and-severe-acute-respiratory-system-sars-related-betacoronaviruses-in-synanthropic-bats-of-luxembourg
#20
Maude Pauly, Jacques B Pir, Catherine Loesch, Aurélie Sausy, Chantal J Snoeck, Judith M Hübschen, Claude P Muller
Several infectious disease outbreaks with high mortality in humans have been attributed to viruses that are thought to have evolved from bat viruses. In this study from Luxembourg, the genetic diversity and epidemiology of paramyxoviruses and coronaviruses shed by the bat species Rhinolophus ferrumequinum and Myotis emarginatus were evaluated. Feces collection (n = 624) was performed longitudinally in a mixed-species colony in 2015 and 2016. In addition, feces (n = 254) were collected cross-sectionally from six Myotis emarginatus colonies in 2016...
September 15, 2017: Applied and Environmental Microbiology
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