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https://www.readbyqxmd.com/read/29126479/fast-probing-of-glucose-and-fructose-in-plant-tissues-via-plasmonic-affinity-sandwich-assay-with-molecularly-imprinted-extraction-microprobes
#1
Pir Muhammad, Jia Liu, Rongrong Xing, Yanrong Wen, Yijia Wang, Zhen Liu
Determination of specific target compounds in agriculture food and natural plant products is essential for many purposes; however, it is often challenging due to the complexity of the sample matrices. Herein we present a new approach called plasmonic affinity sandwich assay for the facile and rapid probing of glucose and fructose in plant tissues. The approach mainly relies on molecularly imprinted plasmonic extraction microprobes, which were prepared on gold-coated acupuncture needles via boronate affinity controllable oriented surface imprinting with the target monosaccharide as the template molecules...
December 1, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/29118270/upregulation-of-pir-gene-expression-induced-by-human-papillomavirus-e6-and-e7-in-epithelial-oral-and-cervical-cells
#2
Diego Carrillo, Juan P Muñoz, Hernán Huerta, Gabriel Leal, Alejandro Corvalán, Oscar León, Gloria M Calaf, Ulises Urzúa, Enrique Boccardo, Julio C Tapia, Francisco Aguayo
The hallmark of high-risk human papillomavirus (HR-HPV)-related carcinogenesis is E6 and E7 oncogene overexpression. The aim of this work was to characterize epithelial oral and cervical cancer cells that express HR-HPV E6 and E7 oncoproteins. Transcriptomic assay using DNA microarrays revealed that PIR gene expression was detected in oral cells in an HR-HPV E6/E7-dependent manner. In addition, PIR was overexpressed in HPV-positive SiHa and Ca Ski cells, whereas it was undetectable in HPV-negative C33A cells...
November 2017: Open Biology
https://www.readbyqxmd.com/read/29113673/esophageal-adenocarcinoma-stage-iii-survival-based-on-pathological-response-to-neoadjuvant-treatment
#3
Katrin Schwameis, Joerg Zehetner, Jeffrey A Hagen, Daniel S Oh, Stephanie G Worrell, Kais Rona, Nathan Cheng, Jamil Samaan, Kyle M Green, John C Lipham
BACKGROUND: Neoadjuvant chemoradiotherapy is the standard treatment for locally advanced esophageal adenocarcinomas (EAC). Pathological response is thought to be a major prognostic factor. Aims of this study were to determine the frequency of complete response and to compare the survival of complete and incomplete responders in stage III EAC. METHODS: A retrospective review was performed of all stage III patients that underwent neoadjuvant therapy followed by esophagectomy between 1999 and 2015...
December 2017: Surgical Oncology
https://www.readbyqxmd.com/read/29101797/blocking-nocturnal-blue-light-for-insomnia-a-randomized-controlled-trial
#4
Ari Shechter, Elijah Wookhyun Kim, Marie-Pierre St-Onge, Andrew J Westwood
The use of light-emitting electronic devices before bedtime may contribute to or exacerbate sleep problems. Exposure to blue-wavelength light in particular from these devices may affect sleep by suppressing melatonin and causing neurophysiologic arousal. We aimed to determine if wearing amber-tinted blue light-blocking lenses before bedtime improves sleep in individuals with insomnia. Fourteen individuals (n = 8 females; age ± SD 46.6 ± 11.5 y) with insomnia symptoms wore blue light-blocking amber lenses or clear placebo lenses in lightweight wraparound frames for 2 h immediately preceding bedtime for 7 consecutive nights in a randomized crossover trial (4-wk washout)...
October 21, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/29100535/construction-and-characterization-of-an-improved-dna-launched-infectious-clone-of-duck-hepatitis-a-virus-type-1
#5
Junhao Chen, Ruihua Zhang, Shaoli Lin, Pengfei Li, Jingjing Lan, Zhijing Xie, Yu Wang, Shijin Jiang
BACKGROUND: DNA-launched infectious system is a useful tool with high rescue efficiency that allows the introduction of mutations in specific positions to investigate the function of an individual viral element. Rescued virus particles could be harvested by directly transfecting the DNA-launched recombinant plasmid to the host cells, which will reduce labor and experimental cost by skipping the in vitro transcription assay. METHODS: A total of four overlapping fragments covering the entire viral genome were amplified and then were assembled into a transformation vector based on pIRES2-EGFP to establish the DNA-launched infectious system of duck hepatitis A virus type 1 (DHAV-1), named pIR-DHAV-1...
November 3, 2017: Virology Journal
https://www.readbyqxmd.com/read/29094444/metformin-as-a-prophylactic-treatment-of-gestational-diabetes-in-pregnant-patients-with-pregestational-insulin-resistance-a-randomized-study
#6
Enrique Valdés, Alvaro Sepúlveda-Martínez, Paula Candia, Nancy Abusada, Rodrigo Orellana, Bárbara Manukian, Eduardo Cuellar
AIM: We aimed to assess the use of metformin (MTF) in the prevention of gestational diabetes mellitus (GDM) in patients with pregestational insulin resistance (PIR). METHODS: A double blind, multicenter, randomized trial was carried out in patients with a history of PIR and pregestational MTF treatment. Groups were allocated either to MTF 1700 mg/day or placebo. Patients were recruited between 12(+0) and 15(+6)  gestational weeks, and treatment was extended until week 36...
November 2, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/29067243/treating-psychological-insulin-resistance-in-type-2-diabetes
#7
Nancy A Allen, Sofija E Zagarins, Rebecca G Feinberg, Garry Welch
AIMS: The phenomenon of psychological insulin resistance (PIR) has been well documented for two decades, but interventions to treat PIR have not been well described. The aim of this study was to describe interventions used to treat psychological insulin resistance by certified diabetes educators (CDE's). METHODS: A secondary data analysis study using empirical data from a trial (N = 234) that included four CDEs providing counseling for psychological insulin resistance...
March 2017: Journal of Clinical & Translational Endocrinology
https://www.readbyqxmd.com/read/29060346/coherence-analysis-of-invasive-blood-pressure-and-its-noninvasive-indicators-for-improvement-of-cuffless-measurement-accuracy
#8
Xiao-Rong Ding, Bryan P Yan, Yuan-Ting Zhang, Jing Liu, Peng Su, Ni Zhao
Cuffless technology for blood pressure (BP) measurement offers great potential for unobtrusive monitoring of hypertension. However, the accuracy is still a challenging issue probably owning to the inadequacy of existing noninvasive BP indicators in tracking BP changes, i.e., either the poor trackability of the indicators or the lack of relationship to map the indicators to BP. To figure out the covariation of BP-related noninvasive indicators and BP, we propose to analyze the coherence of intra-arterial systolic BP (SBP) and a selected group of noninvasive indicators, including the mostly used pulse transit time (PTT), photoplethysmogram intensity ratio (PIR) and RR interval (RRI) of electrocardiogram (ECG), in both time domain, with singular spectrum analysis (SSA), and frequency domain, with cross-spectral analysis...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29056325/pten-regulates-pi-3-4-p2-signaling-downstream-of-class-i-pi3k
#9
Mouhannad Malek, Anna Kielkowska, Tamara Chessa, Karen E Anderson, David Barneda, Pınar Pir, Hiroki Nakanishi, Satoshi Eguchi, Atsushi Koizumi, Junko Sasaki, Véronique Juvin, Vladimir Y Kiselev, Izabella Niewczas, Alexander Gray, Alexandre Valayer, Dominik Spensberger, Marine Imbert, Sergio Felisbino, Tomonori Habuchi, Soren Beinke, Sabina Cosulich, Nicolas Le Novère, Takehiko Sasaki, Jonathan Clark, Phillip T Hawkins, Len R Stephens
The PI3K signaling pathway regulates cell growth and movement and is heavily mutated in cancer. Class I PI3Ks synthesize the lipid messenger PI(3,4,5)P3. PI(3,4,5)P3 can be dephosphorylated by 3- or 5-phosphatases, the latter producing PI(3,4)P2. The PTEN tumor suppressor is thought to function primarily as a PI(3,4,5)P3 3-phosphatase, limiting activation of this pathway. Here we show that PTEN also functions as a PI(3,4)P2 3-phosphatase, both in vitro and in vivo. PTEN is a major PI(3,4)P2 phosphatase in Mcf10a cytosol, and loss of PTEN and INPP4B, a known PI(3,4)P2 4-phosphatase, leads to synergistic accumulation of PI(3,4)P2, which correlated with increased invadopodia in epidermal growth factor (EGF)-stimulated cells...
November 2, 2017: Molecular Cell
https://www.readbyqxmd.com/read/29054162/a-chronological-framework-connecting-the-early-upper-palaeolithic-across-the-central-asian-piedmont
#10
Kathryn E Fitzsimmons, Radu Iovita, Tobias Sprafke, Michelle Glantz, Sahra Talamo, Katharine Horton, Tyler Beeton, Saya Alipova, Galymzhan Bekseitov, Yerbolat Ospanov, Jean-Marc Deom, Renato Sala, Zhaken Taimagambetov
Central Asia has delivered significant paleoanthropological discoveries in the past few years. New genetic data indicate that at least two archaic human species met and interbred with anatomically modern humans as they arrived into northern Central Asia. However, data are limited: known archaeological sites with lithic assemblages generally lack human fossils, and consequently identifying the archaeological signatures of different human groups, and the timing of their occupation, remains elusive. Reliable chronologic data from sites in the region, crucial to our understanding of the timing and duration of interactions between different human species, are rare...
December 2017: Journal of Human Evolution
https://www.readbyqxmd.com/read/29040791/roles-of-mmu_pir_003399-in-microcystin-leucine-arginine-mc-lr-induced-reproductive-toxicity-in-the-spermatogonial-cells-and-testis
#11
Ling Zhang, Xiannan Meng, Zou Xiang, Dongmei Li, Xiaodong Han
Our previous work has demonstrated that microcystin-leucine arginine (MC-LR) is a potent toxin for the reproductive system of male mice and it exerts cytotoxicity in spermatogonial cells, resulting in the constitutional and functional changes of the mouse testis. The present study was designed to investigate the functions of P-element-induced wimpy (piwi)-interacting RNAs (piRNAs) in MC-LR-induced reproductive toxicity in male mice. We observed an increase in the mmu_piR_003399 level in spermatogonial cells and mouse testicular tissues following treatment with MC-LR...
October 12, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29039139/individualizing-the-tibial-tubercle-to-trochlear-groove-distance-to-patient-specific-anatomy-improves-sensitivity-for-recurrent-instability
#12
Mark J Heidenreich, Thomas L Sanders, Mario Hevesi, Nicholas R Johnson, Isabella T Wu, Christopher L Camp, Diane L Dahm, Aaron J Krych
PURPOSE: An initial episode of patellar instability poses a treatment challenge given the absence of a valid, reproducible, and universally applicable predictor of recurrence. Recently, a series of patellar instability ratios (PIRs) were described. Each ratio consisted of the traditional tibial tubercle to trochlear groove (TT-TG) distance normalized to patient-specific measures. The purpose of this study was to investigate the reliability and validity of these novel measures. METHODS: Eighty-seven patients experiencing a first-time lateral patellar dislocation were identified in a retrospective manner...
October 11, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/29021976/learning-curves-for-laparoscopic-repair-of-inguinal-hernia-and-communicating-hydrocele-in-children
#13
Catarina Barroso, Péter Etlinger, Ana Luísa Alves, Angélica Osório, José Luís Carvalho, Ruben Lamas-Pinheiro, Jorge Correia-Pinto
INTRODUCTION: We analyzed the department and surgeon learning curves during implementation of the percutaneous internal ring suturing (PIRS) technique in our department. METHODS: Children proposed for inguinal hernia or communicating hydrocele repair were included (n = 607). After mentorship, all surgeons were free to propose open or PIRS repair. From gathered data, we assessed department and surgeon learning curves through cumulative experience focusing in perioperative complications, conversion, ipsilateral recurrence, postoperative complications, and metachronous hernia, with benchmarks defined by open repair...
2017: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/28985728/outcomes-identified-and-prioritised-by-consumers-of-partners-in-recovery-a-consumer-led-study
#14
Shifra Waks, Justin Newton Scanlan, Bridget Berry, Richard Schweizer, Nicola Hancock, Anne Honey
BACKGROUND: Recovery oriented service provisions means focusing on outcomes that are important to consumers themselves rather than to clinicians or services. Partners in Recovery (PIR) is an Australia-wide initiative designed to provide service coordination and brokerage for individuals with severe and persistent mental illness. One PIR service engaged a consumer-led research team to evaluate the service from the perspective of consumers. This consumer-led study was established to explore PIR consumers' perceptions of outcomes they achieved through their involvement with PIR...
October 6, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28981533/an-improved-camera-trap-for-amphibians-reptiles-small-mammals-and-large-invertebrates
#15
Michael T Hobbs, Cheryl S Brehme
Camera traps are valuable sampling tools commonly used to inventory and monitor wildlife communities but are challenged to reliably sample small animals. We introduce a novel active camera trap system enabling the reliable and efficient use of wildlife cameras for sampling small animals, particularly reptiles, amphibians, small mammals and large invertebrates. It surpasses the detection ability of commonly used passive infrared (PIR) cameras for this application and eliminates problems such as high rates of false triggers and high variability in detection rates among cameras and study locations...
2017: PloS One
https://www.readbyqxmd.com/read/28978781/crystal-structure-of-pharmaceutical-cocrystals-of-2-6-diaminopyridine-with-piracetam-and-theophylline
#16
Melissa Hidekel Durán-Palma, Sonia Sanet Mendoza-Barraza, Nancy Evelyn Magaña-Vergara, Francisco Javier Martínez-Martínez, Juan Saulo González-González
Pharmaceutical cocrystals are crystalline solids formed by an active pharmaceutical ingredient and a cocrystal former. The cocrystals 2,6-diaminopyridine (DAP)-piracetam [PIR; systematic name: 2-(2-oxopyrrolidin-1-yl)acetamide] (1/1), C5H7N3·C6H10N2O2, (I), and 2,6-diaminopyridine-theophylline (TEO; systematic name: 1,3-dimethyl-7H-purine-2,6-dione) (1/1), C5H7N3·C7H8N4O2, (II), were prepared by the solvent-assisted grinding method and were characterized by IR spectroscopy and powder X-ray diffraction. Cocrystal (I) crystallized in the orthorhombic space group Pbca and showed a 1:1 stoichiometry...
October 1, 2017: Acta Crystallographica. Section C, Structural Chemistry
https://www.readbyqxmd.com/read/28976333/a-comparison-of-iterative-reconstruction-and-prone-imaging-in-reducing-the-inferior-wall-attenuation-in-tc-99m-sestamibi-myocardial-perfusion-spect
#17
Duygu Kuşlu, Emel Öztürk
OBJECTIVE: Prone positioning, iterative reconstruction (IR-OSEM) and electrocardiography (ECG) gating have been demonstrated to improve the specificity of myocardial perfusion SPECT (MPS) in the diagnosis of coronary artery disease. METHODS: The gated supine and prone MPS images of 45 patients were reconstructed with both IR-OSEM [supine (SIR) and prone (PIR)] FBPs [supine (SFBP), prone (PFBP)] for comparison. Perfusion, wall motion (WM) and wall thickening were also interpreted semi-quantitatively...
October 3, 2017: Molecular Imaging and Radionuclide Therapy
https://www.readbyqxmd.com/read/28928791/wu-mei-wan-reduces-insulin-resistance-via-inhibition-of-nlrp3-inflammasome-activation-in-hepg2-cells
#18
Xueping Yang, Lingli Li, Ke Fang, Ruolan Dong, Jingbin Li, Yan Zhao, Hui Dong, Ping Yi, Zhaoyi Huang, Guang Chen, Fuer Lu
Wu-Mei-Wan (WMW) is a Chinese herbal formula used to treat type 2 diabetes. In this study, we aimed to explore the effects and mechanisms of WMW on insulin resistance in HepG2 cells. HepG2 cells were pretreated with palmitate (0.25 mM) to impair the insulin signaling pathway. Then, they were treated with different doses of WMW-containing medicated serum and stimulated with 100 nM insulin. Results showed that palmitate could reduce the glucose consumption rate in HepG2 cells and impair insulin signaling related to phosphorylation of insulin receptor (IR) and insulin receptor substrate-1 (IRS-1), thereby regulating the downstream signaling pathways...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28912525/pulse-transit-time-based-continuous-cuffless-blood-pressure-estimation-a-new-extension-and-a-comprehensive-evaluation
#19
Xiaorong Ding, Bryan P Yan, Yuan-Ting Zhang, Jing Liu, Ni Zhao, Hon Ki Tsang
Cuffless technique enables continuous blood pressure (BP) measurement in an unobtrusive manner, and thus has the potential to revolutionize the conventional cuff-based approaches. This study extends the pulse transit time (PTT) based cuffless BP measurement method by introducing a new indicator - the photoplethysmogram (PPG) intensity ratio (PIR). The performance of the models with PTT and PIR was comprehensively evaluated in comparison with six models that are based on sole PTT. The validation conducted on 33 subjects with and without hypertension, at rest and under various maneuvers with induced BP changes, and over an extended calibration interval, respectively...
September 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28912059/piracetam-inhibits-ethanol-etoh-induced-memory-deficit-by-mediating-multiple-pathways
#20
Yifan Yang, Jian Feng, Fangyuan Xu, Jianglin Wang
Excessive ethanol (EtOH) intake, especially to prenatal exposure, can significantly affect cognitive function and cause permanent learning and memory injures in children. As a result, how to protect children from EtOH neurotoxicity has gained increasing attention in recent years. Piracetam (Pir) is a nootropic drug derived from c-aminobutyric acid and can manage cognition impairments in multiple neurological disorders. Studies have shown that Pir can exert therapeutic effects on EtOH-induced memory impairments, but the underlying mechanism is still unknown...
December 1, 2017: Brain Research
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