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https://www.readbyqxmd.com/read/29933495/-baseline-incidence-of-hpv-associated-invasive-and-in-situ-cancers-in-germany-prior-to-potential-vaccination-effects
#1
Christiane Ermina Sophia Rudolph, Alexander Katalinic
AIM: Vaccines against human papillomaviruses are covered by statutory health insurances in Germany since March 2007. A reduction of cervical and other HPV-associated cancers is expected. Incidence rates of HPV-associated cancers preceding the introduction of vaccines are unknown. These, however, are important for assessing the effects of HPV vaccines. The aim of the present study was to bridge this knowledge gap. METHODS: Based on cancer registry data from seven federal states, average yearly incidence rates for cervical, anogenital, oropharyngeal cancers and cancers of the oral cavity were calculated for the period 2003 to 2007...
June 22, 2018: Das Gesundheitswesen
https://www.readbyqxmd.com/read/29932206/saline-irrigation-for-allergic-rhinitis
#2
REVIEW
Karen Head, Kornkiat Snidvongs, Simon Glew, Glenis Scadding, Anne Gm Schilder, Carl Philpott, Claire Hopkins
BACKGROUND: Allergic rhinitis is a common condition affecting both adults and children. Patients experience symptoms of nasal obstruction, rhinorrhoea, sneezing and nasal itching, which may affect their quality of life.Nasal irrigation with saline (salty water), also known as nasal douching, washing or lavage, is a procedure that rinses the nasal cavity with isotonic or hypertonic saline solutions. It can be performed with low positive pressure from a spray, pump or squirt bottle, with a nebuliser or with gravity-based pressure in which the person instils saline into one nostril and allows it to drain out of the other...
June 22, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29931661/demographic-clinical-and-histopathological-features-of-oral-neural-neoplasms-a-retrospective-study
#3
Faraj M Alotaiby, Sarah Fitzpatrick, Jasbir Upadhyaya, Mohammad N Islam, Donald Cohen, Indraneel Bhattacharyya
Intraoral neural neoplasms though unusual may be clinically significant. The aim of this study was to categorize and evaluate oral neural tumors in a large oral pathology biopsy service. With IRB approval, a retrospective search of all neural neoplasms of the oral cavity in the archives of the University of Florida Oral Pathology Biopsy Service spanning from 1994 to 2015 was performed. Extraoral cases as well as cases with insufficient patient information were excluded. A total of 340 out of 164,578 submitted specimens in a 22 year period (0...
June 21, 2018: Head and Neck Pathology
https://www.readbyqxmd.com/read/29931138/do-exposures-to-aerosols-pose-a-risk-to-dental-professionals
#4
J Kobza, J S Pastuszka, E Bragoszewska
Background: Dental care professionals are exposed to aerosols from the oral cavity of patients containing several pathogenic microorganisms. Bioaerosols generated during dental treatment are a potential hazard to dental staff, and there have been growing concerns about their role in transmission of various airborne infections and about reducing the risk of contamination. Aims: To investigate qualitatively and quantitatively the bacterial and fungal aerosols before and during clinical sessions in two dental offices compared with controls...
June 20, 2018: Occupational Medicine
https://www.readbyqxmd.com/read/29931076/effect-of-adding-motolimod-to-standard-combination-chemotherapy-and-cetuximab-treatment-of-patients-with-squamous-cell-carcinoma-of-the-head-and-neck-the-active8-randomized-clinical-trial
#5
Robert L Ferris, Nabil F Saba, Barbara J Gitlitz, Robert Haddad, Ammar Sukari, Prakash Neupane, John C Morris, Krzysztof Misiukiewicz, Julie E Bauman, Moon Fenton, Antonio Jimeno, Douglas R Adkins, Charles J Schneider, Assuntina G Sacco, Keisuke Shirai, Daniel W Bowles, Michael Gibson, Tobenna Nwizu, Raphael Gottardo, Kristi L Manjarrez, Gregory N Dietsch, James Kyle Bryan, Robert M Hershberg, Ezra E W Cohen
Importance: Immunotherapy for recurrent and/or metastatic (R/M) squamous cell carcinoma of the head and neck (SCCHN) is promising. The toll-like receptor 8 (TLR8) agonist motolimod may stimulate innate and adaptive immunity. Objective: To determine whether motolimod improves outcomes for R/M SCCHN when combined with standard therapy. Design, Setting, and Participants: The Active8 study was a multicenter, randomized, double-blind, placebo-controlled clinical trial enrolling adult patients (age ≥18 years) with histologically confirmed R/M SCCHN of the oral cavity, oropharynx, hypopharynx, or larynx between October 2013 and August 2015...
June 21, 2018: JAMA Oncology
https://www.readbyqxmd.com/read/29930395/peri-implantitis-associated-methanogens-a-preliminary-report
#6
Souad Belkacemi, Anthony Mazel, Delphine Tardivo, Patrick Tavitian, Grégory Stephan, Giancarlo Bianca, Elodie Terrer, Michel Drancourt, Gérard Aboudharam
Methanogens have already been described in periodontitis but not in peri-implantitis. Thirty peri-implantitis samples and 28 control samples were collected in 28 consenting peri-implantitis patients. PCR-sequencing of the 16S rRNA gene was used as a broad-spectrum screening method and results were further confirmed by real-time quantitative PCR targeting the mcrA genes. Results showed a methanogen community dominated by Methanobrevibacter oralis in 31/58 (51%) samples including 16/28 (57%) control samples and 15/30 (50%) peri-implantitis samples...
June 21, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29928824/enrichment-of-innate-lymphoid-cell-populations-in-gingival-tissue
#7
J L Brown, L Campbell, J Malcolm, A Adrados Planell, J P Butcher, S Culshaw
Innate lymphoid cells (ILCs) are a population of lymphocytes that act as the first line of immunologic defense at mucosal surfaces. The ILC family in the skin, lungs, and gastrointestinal tissues has been investigated, and there are reports of individual subsets of ILCs in the oral tissues. We sought to investigate the whole ILC population (group 1, 2, and 3 subsets) in the murine gingivae and the lymph nodes draining the oral cavity. We show that ILCs made up a greater proportion of the whole CD45+ lymphocyte population in the murine gingivae (0...
June 1, 2018: Journal of Dental Research
https://www.readbyqxmd.com/read/29927831/anatomical-characterization-and-three-dimensional-modeling-of-the-muscles-at-the-corner-of-the-mouth-an-iodine-staining-technique-based-on-microcomputed-tomography
#8
Min Sun, Guo C Chen, Yong Q Wang, Tao Song, Hai D Li, Di Wu, Ning B Yin
The anatomy of the modiolus and surrounding muscles is complicated and contributes to the morphology of the mouth corner. We used iodine staining and micro-computed tomography (CT) to observe the anatomy of the modiolus and surrounding muscles. Based on the micro-CT images and the 3D model construction, we found that the muscle fibers in the modiolus were oriented continuously in the running direction of the muscle itself and that there were no chaotic clumps in the region of muscle fiber convergence. The pars marginalis of the orbicularis oris muscle connects with the deep buccinators muscle, which may account for how the pars marginalis fibers act to press the upper lip against the maxillary teeth or invert it closer to the oral cavity...
June 14, 2018: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29927825/closure-of-oroantral-fistula-with-buccal-fat-pad-flap-and-endoscopic-drainage-of-the-maxillary-sinus
#9
Mosaad Abdel-Aziz, Mohamed Fawaz, Mohamed Kamel, Ahmed Kamel, Talal Aljeraisi
Oroantral fistula (OAF) is a pathologic communication between the oral cavity and the maxillary sinus. It is usually associated with maxillary sinusitis, where drainage of sinus infection is a mandatory step during closure of the fistula. The flap used for closure of OAF should be tension free, broadly based and well vascularized. The aim of this study was to assess the effectiveness of closure of OAF using buccal fat pad (BFP) flap with concomitant endoscopic middle meatal antrostomy for maxillary sinus drainage...
June 20, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29927817/the-human-papilloma-vaccine-a-time-for-np-leadership
#10
Robin L Hardwicke, Laura J Benjamins, Richard M Grimes
The human papilloma virus (HPV) causes approximately 30,700 annual cancer cases of the cervix, vulva, vagina, penis, oral cavity, and anus. Nurse practitioners can use their unique relationships with patients to advocate for the HPV vaccine. The purpose of this article is to update NPs on current knowledge regarding the HPV vaccine while providing appropriate information necessary for counseling patients and parents.
July 2018: Nurse Practitioner
https://www.readbyqxmd.com/read/29926944/periodontal-health-and-gingival-diseases-and-conditions-on-an-intact-and-a-reduced-periodontium-consensus-report-of-workgroup-1-of-the-2017-world-workshop-on-the-classification-of-periodontal-and-peri-implant-diseases-and-conditions
#11
Iain L C Chapple, Brian L Mealey, Thomas E Van Dyke, P Mark Bartold, Henrik Dommisch, Peter Eickholz, Maria L Geisinger, Robert J Genco, Michael Glogauer, Moshe Goldstein, Terrence J Griffin, Palle Holmstrup, Georgia K Johnson, Yvonne Kapila, Niklaus P Lang, Joerg Meyle, Shinya Murakami, Jacqueline Plemons, Giuseppe A Romito, Lior Shapira, Dimitris N Tatakis, Wim Teughels, Leonardo Trombelli, Clemens Walter, Gernot Wimmer, Pinelopi Xenoudi, Hiromasa Yoshie
Periodontal health is defined by absence of clinically detectable inflammation. There is a biological level of immune surveillance that is consistent with clinical gingival health and homeostasis. Clinical gingival health may be found in a periodontium that is intact, i.e. without clinical attachment loss or bone loss, and on a reduced periodontium in either a non-periodontitis patient (e.g. in patients with some form of gingival recession or following crown lengthening surgery) or in a patient with a history of periodontitis who is currently periodontally stable...
June 2018: Journal of Periodontology
https://www.readbyqxmd.com/read/29926499/periodontal-health-and-gingival-diseases-and-conditions-on-an-intact-and-a-reduced-periodontium-consensus-report-of-workgroup-1-of-the-2017-world-workshop-on-the-classification-of-periodontal-and-peri-implant-diseases-and-conditions
#12
Iain L C Chapple, Brian L Mealey, Thomas E Van Dyke, P Mark Bartold, Henrik Dommisch, Peter Eickholz, Maria L Geisinger, Robert J Genco, Michael Glogauer, Moshe Goldstein, Terrence J Griffin, Palle Holmstrup, Georgia K Johnson, Yvonne Kapila, Niklaus P Lang, Joerg Meyle, Shinya Murakami, Jacqueline Plemons, Giuseppe A Romito, Lior Shapira, Dimitris N Tatakis, Wim Teughels, Leonardo Trombelli, Clemens Walter, Gernot Wimmer, Pinelopi Xenoudi, Hiromasa Yoshie
Periodontal health is defined by absence of clinically detectable inflammation. There is a biological level of immune surveillance that is consistent with clinical gingival health and homeostasis. Clinical gingival health may be found in a periodontium that is intact, i.e. without clinical attachment loss or bone loss, and on a reduced periodontium in either a non-periodontitis patient (e.g. in patients with some form of gingival recession or following crown lengthening surgery) or in a patient with a history of periodontitis who is currently periodontally stable...
June 2018: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/29925731/effects-of-different-resin-adhesives-on-the-microleakage-in-a-new-model-with-simulated-subgingival-condition-and-pulpal-pressure
#13
Zhongjun Liu, Xinyuan Zhao, Xiongqun Zeng, Shuaimei Xu, Yu Lu, Dingming Huang
Resin adhesive restorations are susceptible to oral fluid contamination and greatly influenced by dentinal tubule fluid because of pulpal pressure, especially when the restorative cavities are near gingival tissues. This study designed a novel model to evaluate the microleakage of self-adhesive flowable composite and traditional resin adhesives under simulated subgingival cavity preparations and pulpal pressure. We applied three different adhesive systems, include Vertise Flow, Optibond all-in-one, and Optibond S, on premolars with V-shaped cavity...
June 20, 2018: Dental Materials Journal
https://www.readbyqxmd.com/read/29924757/survival-study-of-leukoplakia-malignant-transformation-in-a-region-of-northern-spain
#14
P Gandara-Vila, M Pérez-Sayans, J-M Suárez-Peñaranda, M Gallas-Torreira, J Somoza-Martín, M-D Reboiras-López, A Blanco-Carrión, A García-García
BACKGROUND: Oral leukoplakia is the most common potentially malignant disorder (PMD) of the oral cavity. The objectives of this study are to determine the clinicopathologic features in a group of patients with oral leukoplakia of Northern Spain (Galicia), determining the factors associated to clinical risk and analyzing the malignant transformation of these patients. MATERIAL AND METHODS: We included 85 patients. We recorded sex and age, habits like alcohol and tobacco, size, clinical appearance, site, number of lesions, and presence or absence of dysplasia...
June 20, 2018: Medicina Oral, Patología Oral y Cirugía Bucal
https://www.readbyqxmd.com/read/29924230/presence-of-candida-spp-and-candidiasis-in-liver-transplant-patients
#15
Samantha Bertoncello Dos Santos, Clarice Elvira Saggin Sabadin, Débora Nunes Mario, Lilian Rigo, Dulce Aparecida Barbosa
BACKGROUND: Candidiasis is the most common opportunistic fungal infection of the oral cavity caused by fungi of the genus Candida and usually associated with immunosuppressed individuals. OBJECTIVES: To evaluate the presence of oral candidiasis and identify the presence of Candida spp. in liver transplant recipients and assess the association between the presence of the fungus and sociodemographic variables, dietary habits and environmental exposure. METHODS: A cross-sectional study was performed with 49 patients who had undergone liver transplants at Hospital São Vicente de Paulo in Passo Fundo - RS...
June 2018: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/29920670/urokinase-plasminogen-activator-protects-periodontal-ligament-fibroblast-from-oxidative-induced-apoptosis-and-dna-damage
#16
M S Ahmad Akhoundi, A Rokn, R Bagheri, N Momeni, M Hodjat
BACKGROUND AND OBJECTIVE: Urokinase-plasminogen activator (uPA) is a serine protease expressed at high basal level in normal gingival cervical fluid. Despite its known pathologic role in tissue proteolysis in periodontitis, little is known concerning uPA physiological function in oral tissue. Recent evidence in cancer cells has implicated the uPA system in DNA repair and anti-apoptotic pathways. This study is aimed to evaluate the protective function of urokinase against oxidative DNA damage in periodontal ligament (PDL) fibroblast, and to propose a new biological role for uPA in oral cavity...
June 19, 2018: Journal of Periodontal Research
https://www.readbyqxmd.com/read/29920600/matrix-metalloproteinase-inhibition-in-a-murine-model-of-cavitary-tuberculosis-paradoxically-worsens-pathology
#17
Alvaro A Ordonez, Supriya Pokkali, Julian Sanchez-Bautista, Mariah H Klunk, Michael E Urbanowski, André Kübler, William R Bishai, Paul T Elkington, Sanjay K Jain
Matrix metalloproteinases (MMPs) degrade extracellular matrix and are implicated in tuberculosis (TB) pathogenesis and cavitation. In particular, MMP-7 is induced by hypoxia and highly expressed around pulmonary cavities of Mycobacterium tuberculosis-infected C3HeB/FeJ mice. In this study, we evaluated whether administration of cipemastat, an orally available potent inhibitor of MMP-7, could reduce pulmonary cavitation in M. tuberculosis-infected C3HeB/FeJ mice. We demonstrate that compared to untreated controls, cipemastat treatment paradoxically increases the frequency of cavitation (32% versus 7%; P = 0...
June 16, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29920473/cystinyl-and-pyroglutamyl-beta-naphthylamide-hydrolyzing-activities-are-modified-coordinately-between-hypothalamus-liver-and-plasma-depending-on-the-thyroid-status-of-adult-male-rats
#18
A B Segarra, I Prieto, M Martinez-Canamero, F Vargas, M De Gasparo, P Vanderheyden, S Zorad, M Ramirez-Sanchez
Stem cells constitute a non-specialised cell pool able for proliferation, self-renewal and differentiation into progeny constantly replacing used up tissue and/or organ fragments. They have been observed to be present in many tissue reservoirs, including stomatognathic system. Oral cavity seems to be a particularly attractive stem cells' source as these cells are richly present and easily accessible in dental and periodontal tissues and they can be used for therapeutic purposes. Their application is also morally and ethically non-controversial...
April 2018: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://www.readbyqxmd.com/read/29917262/clinicopathological-analysis-of-oral-plasmablastic-lymphoma-a-systematic-review
#19
Carla Isabelly Rodrigues-Fernandes, Lucas Lacerda de Souza, Sara Ferreira Dos Santos Costa, André Myller Barbosa Silva, Hélder Antônio Rebelo Pontes, Márcio Ajudarte Lopes, Oslei Paes de Almeida, Peter A Brennan, Felipe Paiva Fonseca
BACKGROUND: Plasmablastic lymphoma (PBL) is a high grade lymphoma that often affects the oral cavity of HIV-positive patients; however, its prognostic determinants remain unknown. PURPOSE: To integrate the available data on oral PBL to determine its clinico-pathological features and to identify potential prognostic factors. METHODS: An electronic systematic review was performed using multiple databases with a specific search strategy in February 2018...
June 19, 2018: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/29916223/ankaferd-blood-stopper-with-antibiofilm-potential-successfully-inhibits-the-extracellular-matrix-degradation-enzymes-and-promotes-wound-healing-of-3t3-fibroblasts-in-vitro
#20
Rukiye Boran, Tuba Baygar, Nurdan Saraç, Aysel Uğur
Background/aim: The potential inhibitory effects of Ankaferd Blood Stopper (ABS) against biofilm formation of oral microorganisms and its capacity for collagenase, hyaluronidase, and elastase inhibitions that have important roles in wound healing have been investigated. Materials and methods: The wound healing potential was determined by its inhibition ability on collagenase, hyaluronidase, and elastase enzyme activities and was evaluated via scratch wound healing assay on murine 3T3 fibroblasts. The antibiofilm activity was tested against eight oral microorganisms using the crystal violet staining method...
June 14, 2018: Turkish Journal of Medical Sciences
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