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https://www.readbyqxmd.com/read/28214285/-local-failures-of-nasopharynx-carcinoma-anatomoclinical-aspects-and-therapeutic-results
#1
L Ghorbal, F Elloumi, W Siala, A Khabir, A Ghorbel, M Frikha, J Daoud
PURPOSE: Retrospective analysis of clinical aspects and therapeutic results of nasopharynx cancer local failures. PATIENTS AND METHODS: Forty patients with local failure with or without nodal involvement of nasopharyngeal carcinoma were treated between 1993 and 2013. Reirradiation of nasopharynx was delivered at the dose of 60Gy. Platinum-based chemotherapy was indicated in case of locally advanced disease and/or associated nodal failure. RESULTS: The mean age at diagnosis of primitive tumour was 41...
February 14, 2017: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/28211009/pneumococcal-predictive-proteins-selected-by-microbial-genomic-approach-are-serotype-cross-reactive-and-bind-to-host-extracellular-matrix-proteins
#2
Ana Paula Corrêa Argondizzo, Cláudio Marcos Rocha-de-Souza, Marta de Almeida Santiago, Ricardo Galler, Joice Neves Reis, Marco Alberto Medeiros
Streptococcus pneumoniae is a colonizer of the human nasopharynx, which accounts for most of the community-acquired pneumonia cases and can cause non-invasive and invasive diseases. Current available vaccines are serotype-specific and the use of recombinant proteins associated with virulence is an alternative to compose vaccines and to overcome these problems. In a previous work, we describe the identification of proteins in S. pneumoniae by reverse vaccinology and the genetic diversity of these proteins in clinical isolates...
February 17, 2017: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/28208911/meningitis-with-digital-gangrene-in-meningococcal-infection-an-atypical-presentation
#3
Jitendra Singh, Dandu Himanshu, Ranjit Kumar Nim, Anju Dinkar, Kamlesh Kumar Gupta
Meningococcal infection is an important public health concern. Neisseria meningitidis usually colonizes the nasopharynx of healthy adolescents and adults and remains as asymptomatic colonizer, while in rare cases it may present as invasive disease as either meningitis or septicemia or both. Most of the cases have typical presentation of rashes. We hereby present a case of a 40-year-old male who presented with meningococcal meningitis and peripheral digital gangrene but without development of typical rashes...
December 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28208894/case-report-of-youngest-successful-bilateral-cartilage-tympanoplasty-in-india
#4
Gaurav Ashish, Ankita Gupta
Paediatric Chronic Suppurative Otitis Media (CSOM) remains a challenge for the treating otologists. Usually, concurrent foci of infection lie in the oropharynx or nasopharynx and treating these eventually leads to resolution of ear discharge. However, refractory cases can be threatening in view of complications secondary to CSOM. A two year and 10-month-old child presented with recurrent profuse mucopurulent ear discharge which had been refractory to multiple medical treatment. Recently she had recurrent otitis external episodes with excoriations of canal skin...
December 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28202381/sphenoid-sinus-carcinoid-tumour-causing-ectopic-acth-syndrome
#5
Sanjaya Perera, Ahmad Taha
A thirty-eight year old patient presented with a gradual increase in weight and Cushingoid facies of two years duration. He also had orbital congestion, with puffy eyelids and corkscrew conjunctival vessels, associated with painful eye movements. An endocrine evaluation revealed raised cortisol and ACTH. Head imaging was performed which showed an enhancing tumour arising from the sphenoid sinus, with osseous erosion of the sphenoid sinus, extending to the nasopharynx, sellar and a small amount extending intracranially...
February 12, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28197925/giant-prolactinoma-presenting-as-a-base-of-skull-tumor-with-nasopharyngeal-extension-a-potential-diagnostic-pitfall-in-neuroendocrine-lesions-of-the-base-of-skull
#6
Amy Prawira, Dorothy Lazinski, Lillian L Siu, Bayardo Perez-Ordonez
Pituitary adenomas presenting in uncommon anatomical locations are commonly misdiagnosed. Dramatic clinical presentation with hemorrhage and infarction, along with a lack of endocrine symptoms may further confound the diagnosis in some patients as illustrated in one of our two previously reported cases of non-small cell neuroendocrine carcinoma of the sinonasal tract and nasopharynx. This report presents the clinical progress of case number 2, which has a revised diagnosis of giant lactotroph pituitary adenoma...
February 14, 2017: Head and Neck Pathology
https://www.readbyqxmd.com/read/28195384/air-pollution-alters-staphylococcus-aureus-and-streptococcus-pneumoniae-biofilms-antibiotic-tolerance-and-colonisation
#7
S J K Hussey, J Purves, N Allcock, V E Fernandes, P S Monks, J M Ketley, P W Andrew, J A Morrissey
Air pollution is the world's largest single environmental health risk (WHO). Particulate matter such as black carbon is one of the main components of air pollution. The effects of particulate matter on human health are well established however the effects on bacteria, organisms central to ecosystems in humans and in the natural environment, are poorly understood. We report here for the first time that black carbon drastically changes the development of bacterial biofilms, key aspects of bacterial colonisation and survival...
February 14, 2017: Environmental Microbiology
https://www.readbyqxmd.com/read/28173955/nasopharyngeal-adenocarcinoma-a-population-based-analysis
#8
Edward C Kuan, Jose E Alonso, Armin Arshi, Maie A St John
OBJECTIVES/HYPOTHESIS: To describe the incidence and determinants of survival of patients with nasopharyngeal adenocarcinoma between the years of 1973 to 2012 using the Surveillance, Epidemiology, and End Result (SEER) database. STUDY DESIGN: Retrospective cohort study using a national database. METHODS: The SEER registry was utilized to calculate survival trends for patients with nasopharyngeal adenocarcinoma between 1973 and 2012. Patient data was then analyzed with respect to histopathology, age, sex, race, stage, grade, and treatment modalities (surgery and radiation therapy)...
January 31, 2017: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/28159927/decreased-expression-of-the-nkg2d-ligand-ulbp4-may-be-an-indicator-of-poor-prognosis-in-patients-with-nasopharyngeal-carcinoma
#9
Yuanji Xu, Lin Zhou, Jingfeng Zong, Yunbin Ye, Gang Chen, Yanping Chen, Xuehong Liao, Qiaojuan Guo, Sufang Qiu, Shaojun Lin, Honglin Chen, Jianji Pan
U16-binding protein 4 (ULBP4), a human ligand for natural killer group 2, member D (NKG2D) receptor on NK cells and subsets of T cells, is thought to activate anticancer immune responses. However, the expression pattern and prognostic effect of ULBP4 in nasopharyngeal carcinoma (NPC) has not been investigated. We first compared ULBP4 expression between archival 15 NPC tissues and 8 normal nasopharynx (NP) tissues using qPCR. Then ULBP4 expression among 111 NPC specimens was validated on immunohistochemical examination...
January 31, 2017: Oncotarget
https://www.readbyqxmd.com/read/28146590/epidemiology-of-otitis-media-with-spontaneous-perforation-of-the-tympanic-membrane-in-young-children-and-association-with-bacterial-nasopharyngeal-carriage-recurrences-and-pneumococcal-vaccination-in-catalonia-spain-the-prospective-hermes-study
#10
Robert Cilveti, Montserrat Olmo, Josefa Pérez-Jove, Juan-José Picazo, Josep-Lluis Arimany, Emiliano Mora, Tomás M Pérez-Porcuna, Ignacio Aguilar, Aurora Alonso, Francesc Molina, María Del Amo, Cristina Mendez
The Epidemiology of otitis media with spontaneous perforation of the tympanic membrane and associated nasopharyngeal carriage of bacterial otopathogens was analysed in a county in Catalonia (Spain) with pneumococcal conjugate vaccines (PCVs) not included in the immunization programme at study time. A prospective, multicentre study was performed in 10 primary care centres and 2 hospitals (June 2011-June 2014), including all otherwise healthy children ≥2 months ≤8 years with otitis media presenting spontaneous tympanic perforation within 48h...
2017: PloS One
https://www.readbyqxmd.com/read/28143570/host-genetic-variation-in-mucosal-immunity-pathways-influences-the-upper-airway-microbiome
#11
Catherine Igartua, Emily R Davenport, Yoav Gilad, Dan L Nicolae, Jayant Pinto, Carole Ober
BACKGROUND: The degree to which host genetic variation can modulate microbial communities in humans remains an open question. Here, we performed a genetic mapping study of the microbiome in two accessible upper airway sites, the nasopharynx and the nasal vestibule, during two seasons in 144 adult members of a founder population of European decent. RESULTS: We estimated the relative abundances (RAs) of genus level bacteria from 16S rRNA gene sequences and examined associations with 148,653 genetic variants (linkage disequilibrium [LD] r (2) < 0...
February 1, 2017: Microbiome
https://www.readbyqxmd.com/read/28139343/lymphoepithelial-carcinoma-in-parotid-gland-related-to-ebv-infection-a-case-report
#12
Hiroyuki Maeda, Takuya Yamashiro, Yukashi Yamashita, Hitoshi Hirakawa, Shinya Agena, Takayuki Uehara, Sen Matayoshi, Mikio Suzuki
Lymphoepithelial carcinoma commonly occurs at the nasopharynx and rarely occurs at other sites in the head and neck region. It is well known to occur at limited patients of local area as Asia or Arctic Circle. Related to this point, it is pointed out that this tumor has strong relation with Epstein-Barr Virus (EBV) infection. In this time, we experienced to treat lymphoepithelial carcinoma with metastatic cervical lymph nodes occurring at parotid gland. The morbidity ratio of this tumor is less than one percent of all parotid gland tumors...
January 27, 2017: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/28137933/genomic-analysis-of-urogenital-and-rectal-neisseria-meningitidis-isolates-reveals-encapsulated-hyperinvasive-meningococci-and-coincident-multidrug-resistant-gonococci
#13
Odile B Harrison, Kevin Cole, Joanna Peters, Fiona Cresswell, Gillian Dean, David W Eyre, John Paul, Martin Cj Maiden
OBJECTIVE: Invasive meningococcal disease (IMD) outbreaks in men who have sex with men (MSM) have been associated with meningococcal colonisation of the urethra and rectum, but little is known about this colonisation or co-colonisation with the closely related gonococcus. Whole genome sequencing (WGS) was employed to explore these phenomena. METHODS: Meningococci isolated from the urogenital tract and rectum (n=23) and coincident gonococci (n=14) were analysed by WGS along with contemporary meningococci from IMD (n=11)...
January 30, 2017: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/28134650/nasopharyngeal-extension-of-giant-meningioma
#14
Mehmet Çelik, Bayram Şahin, Necati Enver, Kadir Serkan Orhan
Meningiomas are common intracranial neoplasms but extracranial meningioma of the paranasal sinus is extremely rare. The recommended treatment of these meningothelial tumors is complete surgical excision. The authors report a 79-year-old woman presenting with facial pain and nasal obstruction for several months. Endoscopic nasopharyngeal examination showed a right nasal mass that arose from the nasopharynx and reached around the middle meatus. Gadolinium-enhanced magnetic resonance imaging showed a well-circumscribed nasopharyngeal mass, which originates from the right rosenmuller fossa and extends to the right nasal cavity...
January 27, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28134649/study-on-the-short-time-remolding-of-upper-airway-after-uvulopalatopharyngoplasty
#15
Kan Yao, Meng Wang, Wenwen Yu, Xiaofeng Lu
OBJECTIVE: To verify the short-time remolding of upper airway in patients diagnosed with obstructive sleep disordered breathing after Uvulopalatopharyngoplasty (UPPP). METHODS: Twenty-one male adult patients aged 27 to 52 years followed up ranged from preoperation to 6 months after the operation. Lateral cephalometric radiographs (conventional and when pronouncing "i") were obtained 2 weeks preoperatively, 3 days postoperatively, and 1, 2, 3, 6 months after the surgery...
January 27, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28133560/endoscopic-resection-of-skull-base-teratoma-in-klippel-feil-syndrome-through-use-of-combined-ultrasonic-and-bipolar-diathermy-platforms
#16
Justin A Edward, Alkis J Psaltis, Ryan A Williams, Gregory W Charville, Robert L Dodd, Jayakar V Nayak
Klippel-Feil syndrome (KFS) is associated with numerous craniofacial abnormalities but rarely with skull base tumor formation. We report an unusual and dramatic case of a symptomatic, mature skull base teratoma in an adult patient with KFS, with extension through the basisphenoid to obstruct the nasopharynx. This benign lesion was associated with midline palatal and cerebral defects, most notably pituitary and vertebrobasilar arteriolar duplications. A multidisciplinary workup and a complete endoscopic, transnasal surgical approach between otolaryngology and neurosurgery were undertaken...
2017: Case Reports in Otolaryngology
https://www.readbyqxmd.com/read/28133482/cephalometrics-of-pharyngeal-airway-space-in-lebanese-adults
#17
Antoine Daraze, Myriam Delatte, Giuseppe Liistro, Zeina Majzoub
Purpose. The upper airway space is significant in orthodontic diagnosis and treatment planning. The objectives of this study are to assess the dimensions of soft tissue elements of the upper pharyngeal space and evaluate potential correlations with modifying variables such as gender, skeletal class, and anthropometric parameters. Materials and Methods. Lateral cephalograms were obtained from 117 healthy young adult Lebanese subjects. Nineteen cephalometric linear/angular measurements of the nasopharynx, oropharynx, and hypopharynx were recorded...
2017: International Journal of Dentistry
https://www.readbyqxmd.com/read/28128848/head-and-neck-cancers-major-changes-in-the-american-joint-committee-on-cancer-eighth-edition-cancer-staging-manual
#18
William M Lydiatt, Snehal G Patel, Brian O'Sullivan, Margaret S Brandwein, John A Ridge, Jocelyn C Migliacci, Ashley M Loomis, Jatin P Shah
Answer questions and earn CME/CNE The recently released eighth edition of the American Joint Committee on Cancer (AJCC) Staging Manual, Head and Neck Section, introduces significant modifications from the prior seventh edition. This article details several of the most significant modifications, and the rationale for the revisions, to alert the reader to evolution of the field. The most significant update creates a separate staging algorithm for high-risk human papillomavirus-associated cancer of the oropharynx, distinguishing it from oropharyngeal cancer with other causes...
January 27, 2017: CA: a Cancer Journal for Clinicians
https://www.readbyqxmd.com/read/28119473/autoinducer-2-signaling-via-the-phosphotransferase-frua-drives-galactose-utilization-by-streptococcus-pneumoniae-resulting-in-hypervirulence
#19
Claudia Trappetti, Lauren J McAllister, Austen Chen, Hui Wang, Adrienne W Paton, Marco R Oggioni, Christopher A McDevitt, James C Paton
: Communication between bacterial cells is crucial for the coordination of diverse cellular processes that facilitate environmental adaptation and, in the case of pathogenic species, virulence. This is achieved by the secretion and detection of small signaling molecules called autoinducers, a process termed quorum sensing. To date, the only signaling molecule recognized by both Gram-positive and Gram-negative bacteria is autoinducer 2 (AI-2), synthesized by the metabolic enzyme LuxS (S-ribosylhomocysteine lyase) as a by-product of the activated methyl cycle...
January 24, 2017: MBio
https://www.readbyqxmd.com/read/28118455/trends-and-patterns-of-disparities-in-cancer-mortality-among-us-counties-1980-2014
#20
Ali H Mokdad, Laura Dwyer-Lindgren, Christina Fitzmaurice, Rebecca W Stubbs, Amelia Bertozzi-Villa, Chloe Morozoff, Raghid Charara, Christine Allen, Mohsen Naghavi, Christopher J L Murray
Introduction: Cancer is a leading cause of morbidity and mortality in the United States and results in a high economic burden. Objective: To estimate age-standardized mortality rates by US county from 29 cancers. Design and Setting: Deidentified death records from the National Center for Health Statistics (NCHS) and population counts from the Census Bureau, the NCHS, and the Human Mortality Database from 1980 to 2014 were used. Validated small area estimation models were used to estimate county-level mortality rates from 29 cancers: lip and oral cavity; nasopharynx; other pharynx; esophageal; stomach; colon and rectum; liver; gallbladder and biliary; pancreatic; larynx; tracheal, bronchus, and lung; malignant skin melanoma; nonmelanoma skin cancer; breast; cervical; uterine; ovarian; prostate; testicular; kidney; bladder; brain and nervous system; thyroid; mesothelioma; Hodgkin lymphoma; non-Hodgkin lymphoma; multiple myeloma; leukemia; and all other cancers combined...
24, 2017: JAMA: the Journal of the American Medical Association
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