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https://www.readbyqxmd.com/read/28748259/primary-nasopharyngeal-polyps-a-case-series-on-a-rare-clinical-entity
#1
De Hua Chen, Mu Qiong Mo, Chew Lip Ng, Zhi Bin Lin, Tian Ying Li, Wei Ping Wen, Chun Wei Li
Primary non-neoplastic polyps originating from the nasopharynx have not been reported in the English language literature. We present the clinical and histopathological features of three primary nasopharyngeal polyps. Clinical data of three patients with primary nasopharyngeal polyps treated at the Department of Otolaryngology, The First Affiliated Hospital of Sun Yat-sen University between 2005 and 2015 were analyzed and presented. Three male patients from 45 to 63 years presented with nasopharyngeal masses...
July 26, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28747370/survival-persistence-and-isolation-of-the-emerging-multidrug-resistant-pathogenic-yeast-candida-auris-on-a-plastic-healthcare-surface
#2
Rory M Welsh, Meghan L Bentz, Alicia Shams, Hollis Houston, Amanda Lyons, Laura J Rose, Anastasia P Litvintseva
The emerging multidrug-resistant pathogenic yeast Candida auris represents a serious threat to global health. Unlike most other Candida species, this organism appears to be commonly transmitted within healthcare facilities and is capable of causing healthcare-associated outbreaks. To better understand the epidemiology of this emerging pathogen we investigated the ability of C. auris to persist on plastic surfaces common in healthcare settings and compared with that of Candida parapsilosis, a species known to colonize the skin and plastics...
July 26, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28745907/role-of-fdg-pet-ct-scan-in-head-and-neck-cancer-patients
#3
Mehrdad Bakhshayesh Karam, Abtin Doroudinia, Ali Safavi Nainee, Fatemeh Kaghazchi, Abbas Yousefi Koma, Payam Mehrian, Farahnaz Agha Hossein
INTRODUCTION: PET/CT scan has an emerging role in head and neck oncology with a few well-established indications, including: detection of unknown primary tumor site, tumor staging, radiotherapy planning, treatment response assessment and detection of recurrent disease. The purpose of this study is reporting PET/CT findings in head and neck cancer patients to emphasize its role in head and neck oncology. MATERIALS AND METHODS: In a retrospective study, we reviewed our PET/CT database and found 94 patients with primary head and neck cancer...
July 2017: Archives of Iranian Medicine
https://www.readbyqxmd.com/read/28744663/serotypes-of-streptococcus-pneumoniae-in-egyptian-children-are-they-covered-by-pneumococcal-conjugate-vaccines
#4
M Badawy, A El Kholy, M M Sherif, E A Rahman, E Ashour, H Sherif, H E Mahmoud, M Hamdy
In Egypt, pneumococcal vaccines have not yet been introduced as being compulsory. Identification of the circulating serotypes in Egypt is mandatory to determine whether or not the pneumococcal vaccines will be beneficial. The current study aims to identify the serotypes, vaccine coverage, and antimicrobial resistance of Streptococcus pneumoniae colonizing the nasopharynx of Egyptian children younger than 5 years old. The study was conducted in two successive winter seasons (December 2012-February 2013 and December 2013-February 2014)...
July 25, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/28744267/the-staphylococcus-aureus-%C3%AE-acetolactate-synthase-als-confers-resistance-to-nitrosative-stress
#5
Sandra M Carvalho, Anne de Jong, Tomas G Kloosterman, Oscar P Kuipers, Lígia M Saraiva
Staphylococcus aureus is a worldwide pathogen that colonizes the human nasal cavity and is a major cause of respiratory and cutaneous infections. In the nasal cavity, S. aureus thrives with high concentrations of nitric oxide (NO) produced by the innate immune effectors and has available for growth slow-metabolizing free hexoses, such as galactose. Here, we have used deep sequencing transcriptomic analysis (RNA-Seq) and (1)H-NMR to uncover how S. aureus grown on galactose, a major carbon source present in the nasopharynx, survives the deleterious action of NO...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28743209/endoscopic-surgery-for-early-stage-nasopharyngeal-carcinoma-a-justified-initial-option
#6
Yan Huang, Qian-Hui Qiu
OBJECTIVES: To assess the prognosis of initial endoscopic surgery in T1N0M0 and T2N0M0 staged NPC patients. MATERIALS AND METHODS: Between 2002 and 2016, 10 previously untreated patients with T1N0M0 or T2N0M0 staged NPC volunteered to receive endoscopic surgery followed by four courses of TPF chemotherapy. EORTC QLQ-C30 and QLQ-H&N35 were used to evaluate the QOL after treatment. RESULTS: With the median follow-up of 30 months (range, 9 months to 128 months), the 24-month survival rate was 100% (6/6), 90% (9/10) patients were still alive and well, 20% (2/10) patients reported tumor recurrence...
July 25, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28742023/genome-wide-identification-of-lineage-and-locus-specific-variation-associated-with-pneumococcal-carriage-duration
#7
John A Lees, Nicholas J Croucher, David Goldblatt, François Nosten, Julian Parkhill, Claudia Turner, Paul Turner, Stephen D Bentley
Streptococcus pneumoniae is a leading cause of invasive disease in infants, especially in low-income settings. Asymptomatic carriage in the nasopharynx is a prerequisite for disease, but variability in its duration is currently only understood at the serotype level. Here we developed a model to calculate the duration of carriage episodes from longitudinal swab data, and combined these results with whole genome sequence data. We estimated that pneumococcal genomic variation accounted for 63% of the phenotype variation, whereas the host traits considered here (age and previous carriage) accounted for less than 5%...
July 25, 2017: ELife
https://www.readbyqxmd.com/read/28736993/molecular-characterization-of-streptococcus-pneumoniae-particularly-serotype19a-st320-that-emerged-in-krasnoyarsk-russia
#8
Irina N Protasova, Tsai-Wen Wan, Natalya V Bakhareva, Wei-Chun Hung, Wataru Higuchi, Yasuhisa Iwao, Tatyana A Yelistratova, Natalya A Ilyenkova, Yelena S Sokolovskaya, Galina P Martynova, Ivan V Reva, Galina V Reva, Sergey V Sidorenko, Lee-Jene Teng, Olga V Peryanova, Alla B Salmina, Tatsuo Yamamoto
Streptococcus pneumoniae, a common human pathogen, colonizes the nasopharynx and causes diseases including acute otitis media (AOM). We herein report pneumococcal serotype distributions in children before and after PCV7 vaccination and in patients with pneumococcal disease in Siberian Russia (Krasnoyarsk). Analyses included antimicrobial susceptibility testing, ST typing, a pulsed-field gel electrophoresis analysis, virulence-related surface protein gene (VSG) typing with novel primers, and a structural analysis by scanning electron microscopy...
July 23, 2017: Microbiology and Immunology
https://www.readbyqxmd.com/read/28736115/three-dimensional-volumetric-changes-in-the-upper-airway-after-maxillomandibular-advancement-in-obstructive-sleep-apnoea-patients-and-the-impact-on-quality-of-life
#9
B Veys, L Pottel, W Mollemans, J Abeloos, G Swennen, N Neyt
Obstructive sleep apnoea (OSA) is a sleep-related breathing disorder, characterized by repetitive airway obstructions, causing disruptive snoring and daytime sleepiness. Maxillomandibular advancement (MMA), which enlarges the upper airway, is a therapeutic surgical approach. However, no study has performed an upper airway sub-region analysis using validated three-dimensional (3D) anatomical and technical limits on cone beam computed tomography (CBCT). Hence, this prospective, observational trial was performed to evaluate 3D volumetric changes in the upper airway according to validated 3D cephalometric landmarks, before and after MMA, for all patients with a polysomnography diagnosis of OSA (apnoea-hypopnoea index (AHI) ≥5)...
July 20, 2017: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28736074/a-novel-genetic-variant-of-streptococcus-pneumoniae-serotype-11a-discovered-in-fiji
#10
Sam Manna, Belinda Ortika, Eileen M Dunne, Kathryn E Holt, Mike Kama, Fiona M Russell, Jason Hinds, Catherine Satzke
OBJECTIVES: As part of annual cross-sectional Streptococcus pneumoniae carriage surveys in Fiji (2012-2015), we detected pneumococci in over 100 nasopharyngeal swabs that serotyped as '11F-like' by microarray. We examined the genetic basis of this divergence in the 11F-like capsular polysaccharide (cps) locus, compared to the reference 11F cps sequence. The impact of this diversity on capsule phenotype, as well as serotyping results using genetic and serological methods, was determined...
July 20, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28718267/giant-haemangioma-of-nasopharynx-a-rare-case-outcome
#11
Haissan Iftikhar, Moghira Iqbaluddin Siddiqui
A 60-year-old female presented to us with a 5-year history of progressive right sided nasal obstruction and recurrent epistaxis. On examination lesion was seen in the right nostril which was firm and bled on probing. CT-scan paranasal sinuses showed a right sided lesion of nose and naso-pharnyx obstructing posterior nasal choanae. Dimensions were reported to be 9×4.1×3.8 cm. A punch biopsy was taken in operating room under general anaesthesia which resulted in profuse bleeding. Suction cautery was used to control bleeding and the nose was packed...
April 2017: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/28714226/extranasopharyngeal-angiofibroma-revisited
#12
Jochen P Windfuhr, Julia Vent
BACKGROUND: Angiofibromas in the head and neck region usually arise in the nasopharynx, but may also occur elsewhere. This study aims at evaluating the incidence and clinical features of extranasopharyngeal angiofibroma (ENA). MATERIAL AND METHODS: Systematic review of the literature (Medline(®) and Google(™) ) up to December 31(st) , 2015. RESULTS: 174 cases of ENA were retrieved from a total of 170 publications. In contrast to former publications and previous understanding, the nasal septum was by far the most common site of the disease...
July 17, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/28713744/access-osteotomy-in-the-maxillofacial-skeleton
#13
REVIEW
K Kamalpathey, Maj Gen N K Sahoo, Col P K Chattopadhyay, Maj Yuvraj Issar
Surgical accesses for the facial skeleton are based on the concept of modular osteotomies. Various techniques and combination of osteotomies facilitate access to the most inaccessible tumors of craniomaxillofacial region. Most appropriate surgical access is determined by considering size, location, extension of the tumor, and experience of the surgical team. These are primarily used for tumors in the nasopharynx or the skull base. The aim of this paper is to review surgical accesses that aid in removal of inaccessible tumors of craniomaxillofacial region with series of cases operated in the Department of Oral and Maxillofacial Surgery, Armed Forces Medical College, Pune, India, between July 2008 and June 2010...
January 2017: Annals of Maxillofacial Surgery
https://www.readbyqxmd.com/read/28711510/serotyping-of-brunei-pneumococcal-clinical-strains-and-the-investigation-of-their-capability-to-adhere-and-invade-a-brain-endothelium-model
#14
Nurul Adhwa Rahman, Aishah Sharudin, Suwarni Diah, Siti Hanna Muharram
INTRODUCTION: Pneumococcal infections have caused morbidity and mortality globally. Streptococcus pneumoniae (pneumococci) are commensal bacteria that colonize the nasopharynx, asymptomatically. From there, pneumococci can spread in the lungs causing pneumonia and disseminate in the bloodstream causing bacteremia (sepsis) and reach the brain leading to meningitis. Endothelial cells are one of the most important components of the blood-brain barrier that separates the blood from the brain and plays the first protective role against pneumococcal entry...
July 12, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28709803/an-ocular-commensal-protects-against-corneal-infection-by-driving-an-interleukin-17-response-from-mucosal-%C3%AE-%C3%AE-t-cells
#15
Anthony J St Leger, Jigar V Desai, Rebecca A Drummond, Abirami Kugadas, Fatimah Almaghrabi, Phyllis Silver, Kumarkrishna Raychaudhuri, Mihaela Gadjeva, Yoichiro Iwakura, Michail S Lionakis, Rachel R Caspi
Mucosal sites such as the intestine, oral cavity, nasopharynx, and vagina all have associated commensal flora. The surface of the eye is also a mucosal site, but proof of a living, resident ocular microbiome remains elusive. Here, we used a mouse model of ocular surface disease to reveal that commensals were present in the ocular mucosa and had functional immunological consequences. We isolated one such candidate commensal, Corynebacterium mastitidis, and showed that this organism elicited a commensal-specific interleukin-17 response from γδ T cells in the ocular mucosa that was central to local immunity...
July 18, 2017: Immunity
https://www.readbyqxmd.com/read/28704569/a-virulence-associated-filamentous-bacteriophage-of-neisseria-meningitidis-increases-host-cell-colonisation
#16
Emmanuelle Bille, Julie Meyer, Anne Jamet, Daniel Euphrasie, Jean-Philippe Barnier, Terry Brissac, Anna Larsen, Philippe Pelissier, Xavier Nassif
Neisseria meningitidis is a commensal of human nasopharynx. In some circumstances, this bacteria can invade the bloodstream and, after crossing the blood brain barrier, the meninges. A filamentous phage, designated MDAΦ for Meningococcal Disease Associated, has been associated with invasive disease. In this work we show that the prophage is not associated with a higher virulence during the bloodstream phase of the disease. However, looking at the interaction of N. meningitidis with epithelial cells, a step essential for colonization of the nasopharynx, we demonstrate that the presence of the prophage, via the production of viruses, increases colonization of encapsulated meningococci onto monolayers of epithelial cells...
July 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28691830/the-effect-of-adenotomy-allergy-and-smoking-on-microbial-colonization-of-upper-aerodigestive-tract-in-children
#17
B Uhliarová, G Bugová, M Jeseňák, S Pechacova, M Hamarova, A Hajtman
AIM: To evaluate microbial colonization of upper aerodigestive tract in children and to investigate the influence of adenoid hypertrophy, allergy and exposition to cigarette smoke on presence of pathogens. METHODS: In 43 children with adenoid hypertrophy and 17 healthy children bacterial culture was performed by a swab from middle nasal meatus, nasopharynx and tonsils. The effect of adenotomy, presence of allergy and exposure to passive smoking on bacterial colonization were investigated...
2017: Epidemiologie, Mikrobiologie, Imunologie
https://www.readbyqxmd.com/read/28688700/a-phase-i-study-of-cabazitaxel-in-combination-with-platinum-and-5-fluorouracil-pf-in-locally-advanced-squamous-cell-carcinoma-of-head-and-neck-la-scchn
#18
Nadia Camille, John Rozehnal, Elizabeth Roy, Dariusz Uczkowski, Ashely Olson, Eric Genden, Marita Teng, Richard Bakst, Vishal Gupta, Marshall Posner, Krzysztof Misiukiewicz
BACKGROUND: There is a clinical need to improve outcomes for patients with locally advanced squamous cell carcinoma of the head and neck (LA-SCCHN), especially in Human Papilloma Virus (HPV) negative and HPV positive subtypes with a significant history of tobacco use. In animal models bearing SCCHN, Cabazitaxel showed an excellent response rate compared to docetaxel and might prove useful in treatment of patients. The primary objective of this study was to determine the dose-limiting toxicity (DLT) and maximum tolerated dose (MTD) of cabazitaxel when combined with cisplatin and 5-fluorouracil (PF) in induction chemotherapy (IC) for patients with SCCHN...
August 2017: Oral Oncology
https://www.readbyqxmd.com/read/28688677/long-term-survival-of-a-randomized-phase-iii-trial-of-head-and-neck-cancer-patients-receiving-concurrent-chemoradiation-therapy-with-or-without-low-level-laser-therapy-lllt-to-prevent-oral-mucositis
#19
Héliton S Antunes, Daniel Herchenhorn, Isabele A Small, Carlos M M Araújo, Celia Maria Pais Viégas, Gabriela de Assis Ramos, Fernando L Dias, Carlos G Ferreira
BACKGROUND: The impact of low-level laser therapy (LLLT) to prevent oral mucositis in patients treated with exclusive chemoradiation therapy remains unknown. This study evaluated the overall, disease-free and progression-free survival of these patients. METHODS: Overall, disease-free and progression-free survival of 94 patients diagnosed with oropharynx, nasopharynx, and hypopharynx cancer, who participated on a phase III study, was evaluated from 2007 to 2015. The patients were subjected to conventional radiotherapy plus cisplatin every 3weeks...
August 2017: Oral Oncology
https://www.readbyqxmd.com/read/28686625/genotyping-assay-for-differentiation-of-wild-type-and-vaccine-viruses-in-subjects-immunized-with-live-attenuated-influenza-vaccine
#20
Victoria Matyushenko, Irina Isakova-Sivak, Tatiana Smolonogina, Irina Dubrovina, Tatiana Tretiak, Larisa Rudenko
Live attenuated influenza vaccines (LAIVs) are considered as safe and effective tool to control influenza in different age groups, especially in young children. An important part of the LAIV safety evaluation is the detection of vaccine virus replication in the nasopharynx of the vaccinees, with special attention to a potential virus transmission to the unvaccinated close contacts. Conducting LAIV clinical trials in some geographical regions with year-round circulation of influenza viruses warrants the development of robust and reliable tools for differentiating vaccine viruses from wild-type influenza viruses in nasal pharyngeal wash (NPW) specimens of vaccinated subjects...
2017: PloS One
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