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https://www.readbyqxmd.com/read/28306199/surgical-management-of-extensive-osteoradionecrosis-in-nasopharyngeal-carcinoma-patients-with-the-maxillary-swing-approach-and-free-muscular-flaps
#1
N Y Choi, H J Kim, Chung-Hwan Baek
Radiation therapy has been a standard treatment for nasopharyngeal carcinoma. However, it can cause extensive osteoradionecrosis which is associated with catastrophic complications including carotid artery rupture, cerebral infection, brain necrosis and cachexia.(1,2,3,4) Most of the cases of limited osteoradionecrosis of the nasopharynx have been treated by endoscopic debridement with a favorable success rate.(3.) This article is protected by copyright. All rights reserved.
March 17, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/28304003/a-huge-thornwaldt-s-cyst-causing-hearing-loss-in-an-adult-patient
#2
Nazim Bozan, Yunus Feyyat Sakin, Pinar Kundi, Muzaffer Ari, Ferhat Bozkus
Nasopharynx (NP) is anatomically difficult to explore adequately. The pharyngeal bursa (PB) is a recess lined with respiratory epithelium along the posterior wall of the nasopharynx between the longus capitis muscles. If the opening through which the bursa drains into the nasopharynx becomes obstructed, a Thornwaldt's cyst (TC) might develop. Small-sized cysts are mostly asymptomatic, whereas large-sized cysts may lead to various nasal and otologic symptoms depending on their localization. In this report, we present a 71-year-old case with a huge TC who presented to our clinic with the complaints of snoring, nasal obstruction, periodic halitosis, postnasal drip, headache, and hearing loss in the left ear and underwent total excision of the cyst through transnasal endoscopy...
March 2017: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/28303956/inhibitory-role-of-acyl-homoserine-lactones-in-hemolytic-activity-and-viability-of-streptococcus-pyogenes-m6-s165
#3
Sunil D Saroj, Linda Holmer, Júlia M Berengueras, Ann-Beth Jonsson
Streptococcus pyogenes an adapted human pathogen asymptomatically colonizes the nasopharynx, among other polymicrobial communities. However, information on the events leading to the colonization and expression of virulence markers subject to interspecies and host-bacteria interactions are limited. The interference of acyl homoserine lactones (AHLs) with the hemolytic activity and viability of S. pyogenes M6 S165 was examined. AHLs, with fatty acid side chains ≥12 carbon atoms, inhibited hemolytic activity by downregulating the expression of the sag operon involved in the production of streptolysin S...
March 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28295284/diffuse-large-b-cell-lymphoma-of-the-nasopharynx-presenting-with-cluster-like-headache
#4
Adrian Budhram, Andrew Leung, Nikhil Sangle, Alexander V Khaw
No abstract text is available yet for this article.
March 13, 2017: Headache
https://www.readbyqxmd.com/read/28291218/-endoscopic-transnasal-surgery-for-giant-fibrous-dysplasia-of-the-skull-base-spreading-to-the-right-orbital-cavity-and-nasopharynx-a-case-report-and-literature-review
#5
A N Shkarubo, A Yu Lubnin, E Yu Bukharin, L V Shishkina, D N Andreev, K V Koval', I V Chernov, V V Karnaukhov
BACKGROUND: An extended endoscopic endonasal approach is increasingly used in surgical treatment of space-occupying skull base lesions. The international literature reports only 20 cases of surgical treatment for fibrous dysplasia (PD) of the skull base using the endoscopic endonasal approach. We present our experience with the endoscopic endonasal approach in surgical treatment for giant fibrous dysplasia of the skull base, spreading to the right orbital cavity and nasopharynx. CLINICAL CASE: A 26-year-old male patient presented with cranial pain, Vth nerve dysfunction on the right, right keratopathy...
2017: Zhurnal Voprosy Neĭrokhirurgii Imeni N. N. Burdenko
https://www.readbyqxmd.com/read/28290215/genetic-assessment-of-leech-species-from-yak-bos-grunniens-in-the-tract-of-northeast-india
#6
Nilkantha Chatterjee, Bishal Dhar, Debasis Bhattarcharya, Sourabh Deori, Juwar Doley, Joken Bam, Pranab J Das, Asit K Bera, Sitangshu M Deb, Ningthoujam Neelima Devi, Rajesh Paul, Sorokhaibam Malvika, Sankar Kumar Ghosh
Yak is an iconic symbol of Tibet and high altitudes of Northeast India. It is highly cherished for milk, meat, and skin. However, yaks suffer drastic change in milk production, weight loss, etc, when infested by parasites. Among them, infestation by leeches is a serious problem in the Himalayan belt of Northeast India. The parasite feeds on blood externally or from body orifices, like nasopharynx, oral, rectum, etc. But there has been limited data about the leech species infesting the yak in that region because of the difficulties in morphological identification due to plasticity of the body, changes in shape, and surface structure and thus, warrants for the molecular characterization of leech...
March 14, 2017: Mitochondrial DNA. Part A. DNA Mapping, Sequencing, and Analysis
https://www.readbyqxmd.com/read/28288168/a-novel-flow-cytometry-based-assay-for-the-quantification-of-antibody-dependent-pneumococcal-agglutination
#7
Marrit N Habets, Saskia van Selm, Christa E van der Gaast-de Jongh, Dimitri A Diavatopoulos, Marien I de Jonge
The respiratory pathogen Streptococcus pneumoniae is a major cause of diseases such as otitis media, pneumonia, sepsis and meningitis. The first step towards infection is colonization of the nasopharynx. Recently, it was shown that agglutinating antibodies play an important role in the prevention of mucosal colonization with S. pneumoniae. Here, we present a novel method to quantify antibody-dependent pneumococcal agglutination in a high-throughput manner using flow cytometry. We found that the concentration of agglutinating antibodies against pneumococcal capsule are directly correlated with changes in the size and complexity of bacterial aggregates, as measured by flow cytometry and confirmed by light microscopy...
2017: PloS One
https://www.readbyqxmd.com/read/28286392/complications-of-midface-swing-for-management-of-juvenile-nasopharyngeal-angiofibroma
#8
Sanjay Roy Chowdhury, K Rajkumar, Tushar Deshmukh
INTRODUCTION: Access osteotomies provide direct exposure to inaccessible areas of the deep part of craniofacial skeleton for treating pathologies involving vital structures. The use of maxillary swing approach for gaining wide access to the nasopharynx, infratemporal fossa, parapharyngeal space, middle fossa of skull base. Though the maxillary swing requires transfacial incision for wide exposure but with careful handling the scar is minimum and this approach can be used in young people...
March 2017: Journal of Maxillofacial and Oral Surgery
https://www.readbyqxmd.com/read/28275173/tropism-and-innate-host-responses-of-influenza-a-h5n6-virus-an-analysis-of-ex%C3%A2-vivo-and-in-vitro-cultures-of-the-human-respiratory-tract
#9
Kenrie P Y Hui, Louisa L Y Chan, Denise I T Kuok, Chris K P Mok, Zi-Feng Yang, Run-Feng Li, Geraldine S M Luk, Elaine F Lee, Jimmy C C Lai, Hui-Ling Yen, Huachen Zhu, Yi Guan, John M Nicholls, J S Malik Peiris, Michael C W Chan
Since their first isolation in 2013, influenza A/H5N6 viruses have spread amongst poultry across multiple provinces in China and to Laos, Vietnam and Myanmar. So far, there have been 14 human H5N6 infections with 10 fatalities.We investigated the tropism, replication competence and cytokine induction of one human and two avian H5N6 isolates in ex vivo and in vitro cultures derived from the human respiratory tract. Virus tropism and replication were studied in ex vivo cultures of human nasopharynx, bronchus and lung...
March 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28270733/nasopharyngeal-non-intestinal-type-adenocarcinoma-a-case-report-and-updated-review-of-the-literature
#10
C Jain, L Caulley, K I Macdonald, B Purgina, C K Lai, B Esche, S Johnson-Obaseki
BACKGROUND: Non-intestinal-type adenocarcinoma is a malignancy traditionally found in the sinonasal cavity. To our knowledge, this case is the first reported of this rare condition originating in the nasopharynx. CASE PRESENTATION: A 67-year-old woman with nasopharyngeal non-intestinal-type adenocarcinoma, with an accompanying parapharyngeal mass received primary radiation treatment for both lesions. Her tumour subsequently persisted, with a concomitant conversion in pathology from a low- to a high-grade malignancy...
February 2017: Current Oncology
https://www.readbyqxmd.com/read/28269757/correlations-of-the-expressions-of-c-jun-and-egr-1-proteins-with-clinicopathological-features-and-prognosis-of-patients-with-nasopharyngeal-carcinoma
#11
Jia-Teng Zhong, Hai-Jun Wang, Jian Yu, Jing-Hang Zhang, Shi-Feng Wang, Xue Yang, Wei Su
This study intended to explore the correlation of the expressions of c-Jun and Egr-1 proteins with clinicopathological features and prognosis of patients with nasopharyngeal carcinoma (NPC). From January 2008 to January 2011, 123 NPC patients and 59 patients with chronic rhinitis were enrolled in this study. Fresh NPC and normal nasopharynx tissue specimens were obtained during surgery. Immunohistochemistry (IHC) was adopted to determine the positive expressions of the c-Jun and Egr-1 proteins. A 5-year clinical follow-up was conducted on all NPC patients...
February 27, 2017: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/28264907/increased-pilus-production-conferred-by-a-naturally-occurring-mutation-alters-host-pathogen-interaction-in-favor-of-carriage-in-streptococcus-pyogenes
#12
Anthony R Flores, Randall J Olsen, Concepcion Cantu, Kyler B Pallister, Fermin E Guerra, Jovanka M Voyich, James M Musser
Studies of the human pathogen group A Streptococcus (GAS) define the carrier phenotype as increased ability to adhere to and persist on epithelial surfaces and decreased ability to cause disease. We tested the hypothesis that a single amino acid change (Arg135Gly) in a highly conserved sensor kinase (LiaS) of a poorly defined GAS regulatory system contributes to a carrier phenotype through increased pilus production. When introduced into an emm serotype-matched invasive strain, the carrier allele (liaS(R135G)) recapitulated a carrier phenotype defined by increased ability to adhere to mucosal surfaces and decreased ability to cause disease...
March 6, 2017: Infection and Immunity
https://www.readbyqxmd.com/read/28264906/inactivation-of-nmb0419-encoding-a-sel1-like-repeat-slr-protein-in-neisseria-meningitidis-is-associated-with-differential-expression-of-genes-belonging-to-the-fur-regulon-and-reduced-intra-epithelial-replication
#13
Ming-Shi Li, Paul R Langford, J Simon Kroll
Neisseria meningitidis is a commensal microbe that colonizes the human nasopharynx but occasionally invades the bloodstream to cause life-threatening infection. N. meningitidis MC58 NMB0419 encodes a Sel1-like repeat (SLR)-containing protein, previously implicated in invasion of epithelial cells. A gene-regulatory function was revealed in Escherichia coli expressing plasmid-borne NMB0419 showing significantly increased epithelial adherence compared to wild type, due to increased expression of mannose-sensitive type 1 pili...
March 6, 2017: Infection and Immunity
https://www.readbyqxmd.com/read/28262704/il-33-st2-immune-responses-to-respiratory-bacteria-in-pediatric-asthma
#14
Isabell Hentschke, Anna Graser, Volker O Melichar, Alexander Kiefer, Theodor Zimmermann, Bettina Kroß, Patricia Haag, Paraskevi Xepapadaki, Nikolaos G Papadopoulos, Christian Bogdan, Susetta Finotto
Here we investigated the relationship between local bacterial colonization and anti-bacterial immune responses in pre-school asthmatic and control children within the EU-wide study PreDicta. In this cohort of pre-school asthmatic children, nasopharyngeal colonization with Gram-negative bacteria such as Haemophilus influenzae and Moraxella catarrhalis was found to be associated with the highest interferon beta (IFNβ) and IL-33 levels in the nasal pharyngeal fluids (NPF). IL33R-ST2 was found induced in the blood of asthmatic children with additional Gram + bacteria in the nasopharynx (Gr+/-)...
March 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28261176/nasopharyngeal-and-oropharyngeal-colonization-by-staphylococcus-aureus-and-streptococcus-pneumoniae-and-prognostic-markers-in-children-with-sickle-cell-disease-from-the-northeast-of-brazil
#15
Larissa C Rocha, Magda O S Carvalho, Valma M L Nascimento, Milena S Dos Santos, Tânia F Barros, Elisângela V Adorno, Joice N Reis, Caroline C da Guarda, Rayra P Santiago, Marilda de Souza Gonçalves
We investigated the nasopharynx and oropharynx microbiota in sickle cell disease (SCD) to identify the microorganisms, antibiotic sensitivity, prevalent serotypes, and association of with laboratorial markers. Oropharynx/nasopharynx secretions were investigated in 143 SCD children aging 6 months to 17 years. Pathogens were isolated using standard procedures, and laboratorial markers were performed by automated methods. Staphylococcus aureus (S. aureus) was isolated from nasopharynx and oropharynx of 64 and of 17 SCD children respectively...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28259949/berberine-inhibits-the-proliferation-of-human-nasopharyngeal-carcinoma-cells-via-an-epstein-barr-virus-nuclear-antigen%C3%A2-1-dependent-mechanism
#16
Chao Wang, Huan Wang, Yaqian Zhang, Wei Guo, Cong Long, Jingchao Wang, Limei Liu, Xiaoping Sun
Nasopharyngeal carcinoma (NPC) is a malignancy derived from the epithelial cells of the nasopharynx cavity, and is closely associated with Epstein-Barr virus (EBV) infection. In addition to NPC, EBV causes various human malignancies, such as gastric cancer, hematological tumors and lymphoepithelioma-like carcinomas. Epstein-Barr nuclear antigen 1 (EBNA1) encoded by EBV is indispensable for replication, partition, transcription and maintenance of viral genomes. Berberine, a naturally occurring isoquinoline alkaloid, shows anti-inflammatory, anticholinergic, antioxidative, and anticancer activities...
March 2, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28247232/update-from-the-4th-edition-of-the-world-health-organization-classification-of-head-and-neck-tumours-nasopharynx
#17
Edward B Stelow, Bruce M Wenig
The current WHO classification system for tumors of the head and neck has made few changes from the previous edition with regards to tumors of the nasopharynx. The classification system is discussed here with particular attention to nasopharyngeal carcinoma, nasopharyngeal papillary adenocarcinoma, salivary gland anlage tumor, hairy polyp, juvenile angiofibroma, and other tumors.
March 2017: Head and Neck Pathology
https://www.readbyqxmd.com/read/28247223/update-from-the-4th-edition-of-the-world-health-organization-classification-of-head-and-neck-tumours-hematolymphoid-tumours
#18
Noah A Brown, Kojo S J Elenitoba-Johnson
In 2017, the latest revision to the WHO Classification of Head and Neck Tumours will be released. Similar to the 2005 WHO, the codification of hematopoietic and lymphoid neoplasms of the head and neck is included within chapters pertaining to the nasal cavity and paranasal sinuses, the nasopharynx, the larynx, the oral cavity and oropharynx, the neck and the salivary glands. Herein, we describe both changes to the classification of hematolymphoid neoplasms of the head and neck since the 2005 WHO, as well as recent advances in our understanding of the underlying pathogenesis and molecular pathology of these neoplasms...
March 2017: Head and Neck Pathology
https://www.readbyqxmd.com/read/28244843/a-simple-diagnostic-scale-based-on-the-analysis-and-screening-of-clinical-parameters-in-paediatric-obstructive-sleep-apnoea-hypopnea-syndrome
#19
D Wu, X Li, X Guo, J Qin, S Li
OBJECTIVE: This study aimed to develop a simple and accurate method to diagnose paediatric obstructive sleep apnoea hypopnea syndrome. METHODS: A total of 311 children with suspected paediatric obstructive sleep apnoea hypopnea syndrome were included in the study. Multiple clinical parameters, including sex, age, body mass index, history of snoring or gasping, history of nasal obstruction, history of running nose, palatine tonsil size, adenoid to nasopharynx ratio, and tympanogram type, were compared with polysomnography results using relevant correlation and regression analyses...
April 2017: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/28241096/the-prognostic-role-of-sex-race-and-human-papillomavirus-in-oropharyngeal-and-nonoropharyngeal-head-and-neck-squamous-cell-cancer
#20
Carole Fakhry, William H Westra, Steven J Wang, Annemieke van Zante, Yuehan Zhang, Eleni Rettig, Linda X Yin, William R Ryan, Patrick K Ha, Alicia Wentz, Wayne Koch, Jeremy D Richmon, David W Eisele, Gypsyamber D'Souza
BACKGROUND: Human papillomavirus (HPV) is a well-established prognostic marker for oropharyngeal squamous cell cancer (OPSCC). Because of the limited numbers of women and nonwhites in studies to date, sex and racial/ethnic differences in prognosis have not been well explored. In this study, survival differences were explored by the tumor HPV status among 1) patients with OPSCCs by sex and race and 2) patients with nonoropharyngeal (non-OP) head and neck squamous cell cancers (HNSCCs)...
February 27, 2017: Cancer
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