keyword
https://read.qxmd.com/read/38533755/seroprevalence-and-renal-carriage-of-pathogenic-leptospira-in-livestock-in-cotonou-benin
#21
JOURNAL ARTICLE
Rebecca Her, Laurent Crespin, Jonas Etougbétché, Karine Groud, Mathias Gnolonfoun, Audrey Chapron, Camille Evenamia, Gualbert Houéménou, Thibaut Lurier, Julien Cappelle, Gauthier Dobigny, Florence Ayral
BACKGROUND: Leptospirosis is a zoonotic disease. It is particularly prevalent in tropical countries and has major consequences for human and animal health. In Benin, the disease's epidemiology remains poorly understood, especially in livestock, for which data are lacking. OBJECTIVES: To characterise Leptospira seroprevalence and locally circulating serogroups in livestock from Cotonou and to estimate the prevalence of Leptospira renal carriage in cattle. METHODS: We conducted a cross-sectional study in February 2020 during which livestock were sampled at an abattoir and in an impoverished city district...
May 2024: Veterinary Medicine and Science
https://read.qxmd.com/read/38533660/glymphatic-system-impairment-contributes-to-the-formation-of-brain-edema-after-ischemic-stroke
#22
JOURNAL ARTICLE
Juan Zhu, Jiaying Mo, Kewei Liu, Quanfeng Chen, Zheqi Li, Yihua He, Yuan Chang, Chuman Lin, Mingjia Yu, Yikai Xu, Xiangliang Tan, Kaibin Huang, Suyue Pan
BACKGROUND: Blood-brain barrier damage has traditionally been considered to determine the occurrence and development of poststroke brain edema, a devastating and life-threatening complication. However, no treatment strategy targeting blood-brain barrier damage has been proven clinically effective in ameliorating brain edema. METHODS: In mice with stroke models induced by transient middle cerebral artery occlusion (MCAO), the changes in glymphatic system (GS) function impairment were detected by ex vivo fluorescence imaging, 2-photon in vivo imaging, and magnetic resonance imaging within 1 week after MCAO, and the effects of GS impairment and recovery on the formation and resolution of brain edema were evaluated...
March 27, 2024: Stroke; a Journal of Cerebral Circulation
https://read.qxmd.com/read/38533643/cardiovascular-effects-of-oral-ketone-ester-treatment-in-patients-with-heart-failure-with-reduced-ejection-fraction-a-randomized-controlled-double-blind-trial
#23
JOURNAL ARTICLE
Kristoffer Berg-Hansen, Nigopan Gopalasingam, Kristian Hylleberg Christensen, Bertil Ladefoged, Mads Jønsson Andersen, Steen Hvitfeldt Poulsen, Barry A Borlaug, Roni Nielsen, Niels Møller, Henrik Wiggers
BACKGROUND: Heart failure triggers a shift in myocardial metabolic substrate utilization, favoring the ketone body 3-hydroxybutyrate as energy source. We hypothesized that 14-day treatment with ketone ester (KE) would improve resting and exercise hemodynamics and exercise capacity in patients with heart failure with reduced ejection fraction. METHODS: In a randomized, double-blind cross-over study, nondiabetic patients with heart failure with reduced ejection fraction received 14-day KE and 14-day isocaloric non-KE comparator regimens of 4 daily doses separated by a 14-day washout period...
March 27, 2024: Circulation
https://read.qxmd.com/read/38533505/ozanimod-mediated-remission-in-experimental-autoimmune-encephalomyelitis-is-associated-with-enhanced-activity-of-cns-cd27-low-nk-cell-subset
#24
JOURNAL ARTICLE
Doua Kamyan, Maya Hassane, Alanood Alnaqbi, Abdul-Kader Souid, Zakeya Al Rasbi, Abeer Al Tahrawi, Mariam Al Shamsi
BACKGROUND: Ozanimod (RPC1063) is an immunomodulator that has been recently approved by the FDA (2020) for the treatment of relapsing-remitting multiple sclerosis (RRMS). It is a selective agonist of the sphingosine-1-phophate receptors 1 and 5, expressed on naïve and central memory T and B cells, as well as natural killer (NK) cells, and is involved in lymphocyte trafficking. Oral administration of ozanimod was reported to result in rapid and reversible reduction in circulating lymphocytes in multiple sclerosis (MS) patients, however, only minimal effect on NK cells was observed...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38533436/a-large-gastric-splenosis-mimicking-gastrointestinal-stromal-tumor-a-case-report-and-literature-review
#25
Xiaotian Li, Xianwen Hu, Pan Wang, Guiyun Hu, Bin Zhou, Jiong Cai
Splenosis pertains to the phenomenon wherein a segment of the spleen undergoes detachment and becomes embedded in other anatomical regions subsequent to traumatic rupture or therapeutic resection, and then progressively establishing blood circulation to foster the regeneration of splenic tissue. Existing literature posits that splenosis predominantly manifests within the confines of the abdominal and pelvic cavities. The objective of the current study was to present an uncommon case involving the occurrence of splenosis within the gastric myometrium, thereby contributing to the current knowledge regarding splenosis...
May 2024: Experimental and Therapeutic Medicine
https://read.qxmd.com/read/38533257/naodesheng-decoction-regulating-vascular-function-via-g-protein-coupled-receptors-network-analysis-and-experimental-investigations
#26
JOURNAL ARTICLE
Shuhan Chen, Ziran Niu, Yanjia Shen, Wendan Lu, Jiaying Zhao, Huilin Yang, Minmin Guo, Li Zhang, Ruifang Zheng, Guanhua Du, Li Li
Introduction: Ischemic stroke (IS) is a detrimental neurological disease with limited treatment options. Recanalization of blocked blood vessels and restoring blood supply to ischemic brain tissue are crucial for post-stroke rehabilitation. The decoction Naodesheng (NDS) composed of five Chinese botanical drugs, including Panax notoginseng (Burk.) F. H. Chen, Ligusticum chuanxiong Hort., Carthamus tinctorius L., Pueraria lobata (Willd.) Ohwi, and Crataegus pinnatifida Bge., is a blood-activating and stasis-removing herbal medicine commonly used for the clinical treatment of cerebrovascular diseases in China...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38532845/acute-response-in-circulating-micrornas-following-a-single-bout-of-short-sprint-and-heavy-strength-training-in-well-trained-cyclists
#27
JOURNAL ARTICLE
Anita Ryningen, Kari Rostad, Elisabeth Ersvær, Gry Sjøholt, Gøran Paulsen, Hilde Gundersen, Morten Kristoffersen, Lise Bjørkhaug
Background: Heavy strength (HS) and short-sprint (SS) are commonly used training methods for competitive road cyclists, with the aim to improve the anaerobic power and short time cycling performance. Knowledge of how such training methods affects biochemical as well as molecular factors, are particularly important for determining individual recovery and long-term adaptations. The primary aim of the current study was to investigate the expression levels of small non-coding RNAs in response to HS and SS training in elite cyclists as potential biomarkers for individual optimal restitution time...
2024: Frontiers in Physiology
https://read.qxmd.com/read/38532784/the-s1-subunits-of-sars-cov-2-variants-differentially-trigger-the-il-6-signaling-pathway-in-human-brain-endothelial-cells-and-downstream-impact-on-microglia-activation
#28
JOURNAL ARTICLE
Michael Stangis, Daniel Adesse, Bhavya Sharma, Eduardo Castro, Kush Kumar, Neil Kumar, Masha Minevich, Michal Toborek
OBJECTIVES: Cerebrovascular complications are prevalent in COVID-19 infection and post-COVID conditions; therefore, interactions of SARS-CoV-2 with cerebral microvascular cells became an emerging concern. METHODS: We examined the inflammatory responses of human brain microvascular endothelial cells (HBMEC), the main structural element of the blood-brain barrier (BBB), following exposure to the S1 subunit of the spike protein of different SARS-CoV-2 variants. Specifically, we used the S1 subunit derived from the D614 variant of SARS-CoV-2, which started widely circulating in March of 2020, and from the Delta variant, which started widely circulating in early 2021...
March 2024: NeuroImmune Pharm Ther
https://read.qxmd.com/read/38532190/exosomal-micrornas-in-parkinson-s-disease-insights-into-biomarker-potential-and-disease-pathology
#29
REVIEW
Deepthy Chandran, Syam Krishnan, Madhusoodanan Urulangodi, Srinivas Gopala
Parkinson's disease (PD) is a prevalent neurodegenerative condition primarily affecting the elderly population. Despite its high incidence in aged individuals, there are no reliable blood-based biomarkers for clinical diagnosis of PD and early screening of susceptible individuals. Recent studies have revealed the significance of exosomes in mediating cell-to-cell communications by transferring bioactive molecules, such as proteins, nucleic acids (including miRNAs), lipids, and metabolites, between cells. Due to their ability to carry diverse molecular cargo and their involvement in various physiological and pathological processes, exosomes have gained significant attention as potential disease biomarkers...
March 27, 2024: Neurological Sciences
https://read.qxmd.com/read/38532078/a-phase-1-2-study-of-ns-87-cpx-351-cytarabine-and-daunorubicin-liposome-in-japanese-patients-with-high-risk-acute-myeloid-leukemia
#30
JOURNAL ARTICLE
Kensuke Usuki, Toshihiro Miyamoto, Takuji Yamauchi, Kiyoshi Ando, Yoshiaki Ogawa, Masahiro Onozawa, Takahiro Yamauchi, Hitoshi Kiyoi, Akira Yokota, Takayuki Ikezoe, Yuna Katsuoka, Satoru Takada, Nobuyuki Aotsuka, Yasuyoshi Morita, Takayuki Ishikawa, Noboru Asada, Shuichi Ota, Atsushi Dohi, Kensaku Morimoto, Shunji Imai, Umi Kishimoto, Koichi Akashi, Yasushi Miyazaki
OBJECTIVES: NS-87/CPX-351 is a dual-drug liposomal encapsulation of cytarabine and daunorubicin. NS-87/CPX-351 exerts antileukemic action by maintaining a synergistic molar ratio of cytarabine to daunorubicin of 5:1 within the liposome while in circulation. Patients with high-risk acute myeloid leukemia (AML), which includes therapy-related AML and AML with myelodysplasia-related changes (AML-MRC), have poorer outcomes than those with other AML. METHODOLOGY: This open-label phase 1/2 (P1/2) study was conducted in 47 Japanese patients aged 60-75 years with newly diagnosed high-risk AML to evaluate the pharmacokinetics, safety, and efficacy of NS-87/CPX-351...
March 26, 2024: International Journal of Hematology
https://read.qxmd.com/read/38531808/implementable-assay-for-monitoring-minimum-residual-disease-after-radical-treatment-for-colorectal-cancer
#31
JOURNAL ARTICLE
Takafumi Nakano, Seiichiro Takao, Katsushi Dairaku, Naoki Uno, Siew-Kee Amanda Low, Masahiro Hashimoto, Yasuo Tsuda, Yuichi Hisamatsu, Takeo Toshima, Yusuke Yonemura, Takaaki Masuda, Ken Eto, Toru Ikegami, Yosuke Fukunaga, Atsushi Niida, Satoshi Nagayama, Koshi Mimori
Considering the cost and invasiveness of monitoring postoperative minimal residual disease (MRD) of colorectal cancer (CRC) after adjuvant chemoradiotherapy (ACT), we developed a favorable approach based on methylated circulating tumor DNA to detect MRD after radical resection. Analyzing the public database, we identified the methylated promoter regions of the genes FGD5, GPC6, and MSC. Using digital polymerase chain reaction (dPCR), we termed the "amplicon of methylated sites using a specific enzyme" assay as "AMUSE...
March 26, 2024: Cancer Science
https://read.qxmd.com/read/38531427/outbreak-of-persistently-infected-heifer-calves-with-bovine-viral-diarrhea-virus-subgenotypes-1b-and-1d-in-a-bvdv-vaccinated-open-dairy-herd
#32
JOURNAL ARTICLE
Juliana Torres Tomazi Fritzen, Natalia Zaparoli Zucoloto, Elis Lorenzetti, Alice Fernandes Alfieri, Amauri Alcindo Alfieri
Bovine viral diarrhea virus (BVDV) infection has a significant economic impact on beef and dairy industries worldwide. Fetal infection with a non-cytopathic strain may lead to the birth of persistently infected (PI) offspring, which is the main event in the epidemiological chain of BVDV infection. This report describes the birth of 99 BVDV-PI heifer calves within 52 days of birth in a regular BVDV-vaccinated Brazilian dairy cattle herd and the subgenotypes of the infecting field strains. This study was conducted in a high-yielding open dairy cattle herd that frequently acquired heifers from neighboring areas for replacement...
March 24, 2024: Acta Tropica
https://read.qxmd.com/read/38531361/twin-study-dissects-cxcr3-memory-b-cells-as-non-heritable-feature-in-multiple-sclerosis
#33
JOURNAL ARTICLE
Florian Ingelfinger, Kirsten L Kuiper, Can Ulutekin, Lukas Rindlisbacher, Sarah Mundt, Lisa Ann Gerdes, Joost Smolders, Marvin M van Luijn, Burkhard Becher
BACKGROUND: In multiple sclerosis (MS), B cells are considered main triggers of the disease, likely as the result of complex interaction between genetic and environmental risk factors. Studies on monozygotic twins discordant for MS offer a unique way to reduce this complexity and reveal discrepant subsets. METHODS: In this study, we analyzed B cell subsets in blood samples of monozygotic twins with and without MS using publicly available data. We verified functional characteristics by exploring the role of therapy and performed separate analyses in unrelated individuals...
March 18, 2024: Med
https://read.qxmd.com/read/38531214/fetal-anemia-causes-placental-and-maternal-cellular-damage-a-lesson-from-fetal-hemoglobin-bart-s-disease
#34
JOURNAL ARTICLE
Suchaya Luewan, Nattayaporn Apaijai, Nipon Chattipakorn, Siriporn Chattipakorn, Theera Tongsong
INTRODUCTION: The studies about effect of fetal anemia on placental and maternal molecular changes have rarely been published. This study aimed to compare oxidative stress levels and mitochondrial function in the placenta and maternal peripheral blood mononuclear cell (PMBCs) between anemic fetuses (using fetal Hb Bart's disease as a study model) and non-anemic fetuses. METHODS: A cross-sectional study was conducted on pregnancies affected by Hb Bart's disease and non-anemic fetuses between 16 and 22 weeks of gestation...
March 21, 2024: Placenta
https://read.qxmd.com/read/38531201/cirp-increases-foxp3-regulatory-t-cells-and-inhibits-development-of-th17-cells-by-enhancing-tlr4-il-2-signaling-in-the-late-phase-of-sepsis
#35
JOURNAL ARTICLE
Zongsheng Wu, Xu Liu, Wei Huang, Jing Chen, Songli Li, Jie Chao, Jianfeng Xie, Ling Liu, Yi Yang, Xiaojing Wu, Haibo Qiu
BACKGROUND: T helper (Th) cell imbalances have been associated with the pathophysiology of sepsis, including the Th1/Th2 and Th17/T regulatory cells (Treg) paradigms. Cold-inducible RNA-binding protein (CIRP), a novel damage-associated molecular pattern (DAMP) was reported that could induce T cell activation, and skew CD4+ T cells towards a Th1 profile. However, the effect and underlying mechanisms of CIRP on Th17/Treg differentiation in sepsis still remains unknown. METHODS: A prospective exploratory study including patients with sepsis was conducted...
March 25, 2024: International Immunopharmacology
https://read.qxmd.com/read/38531082/adhesive-arachnoiditis-subarachnoid-hemorrhage-and-intradural-extramedullary-thoracic-cavernoma-illustrative-case
#36
JOURNAL ARTICLE
Agne Andriuskeviciute, Michel Gustavo Mondragón-Soto, Nicolas Penet, Juan Barges-Coll
BACKGROUND: Spinal arachnoiditis can result from various factors, including spinal subarachnoid hemorrhage (sSAH). In this paper, the authors describe a case of intradural extramedullary cavernoma with an initial presentation of subarachnoid hemorrhage leading to multilevel spinal arachnoiditis to discuss the pathophysiology and optimal treatment strategy. OBSERVATIONS: Spinal intradural extramedullary cavernoma manifesting with sSAH is a rare clinical presentation; therefore, there is no clear strategy for the management of sSAH...
March 25, 2024: J Neurosurg Case Lessons
https://read.qxmd.com/read/38530856/identification-of-macaque-dendritic-cell-precursors-in-blood-and-tissue-reveals-their-dysregulation-in-early-siv-infection
#37
JOURNAL ARTICLE
Margaux Gardet, Oscar Haigh, Florian Meurisse, Sixtine Coindre, Nastasia Dimant, Delphine Desjardins, Christine Bourgeois, Cecile Goujard, Bruno Vaslin, Francis Relouzat, Roger Le Grand, Olivier Lambotte, Benoit Favier
Distinct dendritic cell (DC) subsets play important roles in shaping immune responses. Circulating DC precursors (pre-DCs) are more susceptible to HIV infection in vitro, which may explain the inefficiency of immune responses against HIV. However, the interplay between HIV and pre-DC is not defined in vivo. We identify human pre-DC equivalents in the cynomolgus macaque and then analyze their dynamics during simian immunodeficiency virus (SIV) infection to illustrate a sharp decrease of blood pre-DCs in early SIV infection and accumulation in lymph nodes (LNs), where they neglect to upregulate CD83/CD86 or MHC-II...
March 25, 2024: Cell Reports
https://read.qxmd.com/read/38530625/acute-high-output-heart-failure-with-pulmonary-hypertension-and-severe-liver-injury-caused-by-amlodipine-poisoning-a-case-report
#38
JOURNAL ARTICLE
Chenlong Wang, Qingcheng Zhu, Dingyu Tan, Joseph Walline, Yachao Wang
Acute high-output heart failure (HOHF) with pulmonary hypertension and liver injury caused by amlodipine poisoning is very rare. We report a 52-year-old woman who suffered from severe shock after an overdose of amlodipine. Hemodynamic monitoring showed that while her left ventricular systolic function and cardiac output were elevated, her systemic vascular resistance decreased significantly. At the same time, the size of her right heart, her central venous pressure, and the oxygen saturation of her central venous circulation all increased abnormally...
March 26, 2024: Cardiovascular Toxicology
https://read.qxmd.com/read/38530139/fenretinide-in-young-women-at-genetic-or-familial-risk-of-breast-cancer-a-placebo-controlled-biomarker-trial
#39
JOURNAL ARTICLE
Valentina Aristarco, Davide Serrano, Patrick Maisonneuve, Aliana Guerrieri-Gonzaga, Matteo Lazzeroni, Irene Feroce, Debora Macis, Elena Cavadini, Elena Albertazzi, Costantino Jemos, Emanuela Omodeo Salè, Laura Cortesi, Samuele Massarut, Marcella Gulisano, Maria Grazia Daidone, Harriet Johansson, Bernardo Bonanni
Fenretinide, a retinoid with a low toxicity profile that accumulates in the breast, has been shown to prevent second breast cancer in young women. Fenretinide exhibits apoptotic and anti-invasive properties and it improves insulin sensitivity in overweight premenopausal women with insulin resistance. The present study aimed to further characterize its role in cancer prevention by measuring circulating biomarkers related to insulin sensitivity and breast cancer risk. Sixty-two women, aged 20 to 46 years, healthy or who had already undergone breast cancer surgery, with a known BRCA1/2 mutation or a likelihood of mutation ≥ 20% according to the BRCAPRO model, were randomly assigned to receive fenretinide (200 mg/day) or placebo for 5 years (trial registration: EudraCT Number: 2009-010260-41)...
March 26, 2024: Cancer Prevention Research
https://read.qxmd.com/read/38529925/-circulatory-failure-after-bupropion-overdose
#40
JOURNAL ARTICLE
Erik Norberg, Kai Knudsen, Andreas Blomgren, Marc Stevens, Erik Lindeman, Johanna Nordmark Grass
A case of massive overdose of sustained release bupropion tablets is described. The patient presented with GCS 3, tachycardic and in vasoplegic shock. ECHO and EKG were initially normal. The hemodynamic situation was stabilised with vasopressors, but 18 h after presentation the patient deteriorated with wide complex arrhythmias rapidly progressing to cardiac arrest. The patient was put on VA-ECMO after 35 minutes of CPR. Circulation could be stabilized and ECMO was discontinued after 36 h. The patient was extubated on day 6 and made a complete recovery on discharge two weeks after presentation...
March 26, 2024: Läkartidningen
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