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Xenotransplantation

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https://www.readbyqxmd.com/read/29777547/tacrolimus-induced-asymptomatic-thrombotic-microangiopathy-diagnosed-by-laboratory-tests-in-pig-to-rhesus-corneal-xenotransplantation-a-case-report
#1
Jong-Min Kim, Jaeyoung Kim, Se-Hyun Choi, Jun-Seop Shin, Byoung-Hoon Min, Won Young Jeong, Ga-Eul Lee, Min-Sun Kim, Seeun Kwon, Mee Kum Kim, Chung-Gyu Park
Tacrolimus-associated thrombotic microangiopathy (TA-TMA) is a rare complication. TA-TMA is characterized by microangiopathic hemolytic anemia, thrombocytopenia, and organ damage due to thrombus. We report asymptomatic TA-TMA diagnosed by laboratory tests in pig-to-rhesus corneal xenotransplantation. Corneal transplantation had been conducted from a wild-type SNU miniature pig to a rhesus macaque. The veterinary records were retrospectively reviewed in this case. The immunosuppressive regimen consisted of rituximab, basiliximab, and IVIg as inductive therapies, and steroids with tacrolimus (0...
May 18, 2018: Xenotransplantation
https://www.readbyqxmd.com/read/29772458/phenotyping-and-target-expression-profiling-of-cd34-cd38-and-cd34-cd38-stem-and-progenitor-cells-in-acute-lymphoblastic-leukemia
#2
Katharina Blatt, Ingeborg Menzl, Gregor Eisenwort, Sabine Cerny-Reiterer, Harald Herrmann, Susanne Herndlhofer, Gabriele Stefanzl, Irina Sadovnik, Daniela Berger, Alexandra Keller, Alexander Hauswirth, Gregor Hoermann, Michael Willmann, Thomas Rülicke, Heinz Sill, Wolfgang R Sperr, Christine Mannhalter, Junia V Melo, Ulrich Jäger, Veronika Sexl, Peter Valent
Leukemic stem cells (LSCs) are an emerging target of curative anti-leukemia therapy. In acute lymphoblastic leukemia (ALL), LSCs frequently express CD34 and often lack CD38. However, little is known about markers and targets expressed in ALL LSCs. We have examined marker- and target expression profiles in CD34+ /CD38- LSCs in patients with Ph+ ALL (n = 22) and Ph- ALL (n = 27) by multi-color flow cytometry and qPCR. ALL LSCs expressed CD19 (B4), CD44 (Pgp-1), CD123 (IL-3RA), and CD184 (CXCR4) in all patients tested...
May 14, 2018: Neoplasia: An International Journal for Oncology Research
https://www.readbyqxmd.com/read/29767012/corrigendum-to-the-role-of-costimulation-blockade-in-solid-organ-and-islet-xenotransplantation
#3
Kannan P Samy, James R Butler, Ping Li, David K C Cooper, Burcin Ekser
[This corrects the article DOI: 10.1155/2017/8415205.].
2018: Journal of Immunology Research
https://www.readbyqxmd.com/read/29757700/adhesion-characteristics-of-porcine-pancreatic-islets-and-exocrine-tissue-to-coating-materials
#4
Yoshiki Nakashima, Chika Miyagi-Shiohira, Naoya Kobayashi, Issei Saitoh, Masami Watanabe, Hirofumi Noguchi
Since the report of the Edmonton protocol in 2000, islet transplantation has been implemented worldwide, and xenotransplantation using porcine islets has also been reported. In addition, many basic experiments using pancreatic islets and exocrine tissue after isolation have been reported. Recently, exocrine cells have been found to be essential for inducing the differentiation of pancreatic islets. Therefore, the importance of the culture conditions for pancreatic tissue when conducting experiments using pancreatic tissue is also increasing...
May 14, 2018: Islets
https://www.readbyqxmd.com/read/29756348/is-it-currently-possible-to-evaluate-the-risk-posed-by-pervs-for-clinical-xenotransplantation
#5
Joachim Denner, Linda Scobie, Henk-Jan Schuurman
No abstract text is available yet for this article.
May 13, 2018: Xenotransplantation
https://www.readbyqxmd.com/read/29756309/infection-hazards-of-xenotransplantation-retrospect-and-prospect
#6
Robin A Weiss
No abstract text is available yet for this article.
May 13, 2018: Xenotransplantation
https://www.readbyqxmd.com/read/29755422/porcine-endogenous-retrovirus-perv-molecular-structure-and-replication-strategy-in-the-context-of-retroviral-infection-risk-of-human-cells
#7
REVIEW
Krzysztof Łopata, Emilia Wojdas, Roman Nowak, Paweł Łopata, Urszula Mazurek
The xenotransplantation of porcine tissues may help overcome the shortage of human organs for transplantation. However, there are some concerns about recipient safety because the risk of porcine endogenous retrovirus (PERV) transmission to human cells remains unknown. Although, to date, no PERV infections have been noted in vivo , the possibility of such infections has been confirmed in vitro . Better understanding of the structure and replication cycle of PERVs is a prerequisite for determining the risk of infection and planning PERV-detection strategies...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29752586/comparison-of-tracheal-reconstruction-with-allograft-fresh-xenograft-and-artificial-trachea-scaffold-in-a-rabbit-model
#8
Jae Yeon Lee, Jeong Hun Park, Dong-Woo Cho
This study evaluated the possibility of tracheal reconstruction with allograft, pig-to-rabbit fresh xenograft or use of a tissue-engineered trachea, and compared acute rejection of three different transplanted tracheal segments in rabbits. Eighteen healthy New Zealand White rabbits weighing 2.5-3.1 kg were transplanted with three different types of trachea substitutes. Two rabbits and two alpha 1, 3-galactosyltransferase gene-knockout pigs weighing 5 kg were used as donors. The rabbits were divided into three groups: an allograft control group consisting of rabbit-to-rabbit allotransplantation animals (n = 6), a fresh xenograft group consisting of pig-to-rabbit xenotransplantation animals (n = 6), and an artificial trachea scaffold group (n = 6)...
May 12, 2018: Journal of Artificial Organs: the Official Journal of the Japanese Society for Artificial Organs
https://www.readbyqxmd.com/read/29750148/expression-and-regulation-profile-of-mature-microrna-in-the-pig-relevance-to-xenotransplantation
#9
REVIEW
Zongpei Song, David K C Cooper, Zhiming Cai, Lisha Mou
The pig is an important source of meat production and provides a valuable model for certain human diseases. MicroRNA (miRNA), which is noncoding RNA and regulates gene expression at the posttranscriptional level, plays a critical role in various biological processes. Studies on identification and function of mature miRNAs in multiple pig tissues are increasing, yet the literature is limited. Therefore, we reviewed current research to determine the miRNAs expressed in specific pig tissues that are involved in carcass values (including muscle and adipocytes), reproduction (including pituitary, testis, and ovary), and development of some solid organs (e...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29743561/leukaemic-alterations-of-ikzf1-prime-stemness-and-malignancy-programs-in-human-lymphocytes
#10
Zhen Li, Shui-Ping Li, Ruo-Yan Li, Hua Zhu, Xia Liu, Xiao-Lin Guo, Li-Li Mu, Jie-Jing Cai, Fan Bai, Guo-Qiang Chen, Deng-Li Hong
Somatic cells acquire stem cell-like properties during cancerous transformation; however, mechanisms through which committed cells develop stemness and malignancy remain largely unknown. Here we uncovered upregulated stem cell program in leukaemic lymphoblasts of patients with IKZF1 alterations by analysing the archived gene-expression profiling datasets. We then used a frequent IKZF1 deletion, IK6, as a model via transduction into human primitive haematopoietic cells, followed by xenotransplantation in mice...
May 9, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29732615/update-on-cellular-encapsulation
#11
REVIEW
Kate E Smith, Robert C Johnson, Klearchos K Papas
There is currently a significant disparity between the number of patients who need lifesaving transplants and the number of donated human organs. Xenotransplantation is a way to address this disparity and attempts to enable the use of xenogeneic tissues have persisted for centuries. While immunologic incompatibilities have presented a persistent impediment to their use, encapsulation may represent a way forward for the use of cell-based xenogeneic therapeutics without the need for immunosuppression. In conjunction with modern innovations such as the use of bioprinting, incorporation of immune modulating molecules into capsule membranes, and genetic engineering, the application of xenogeneic cells to treat disorders ranging from pain to liver failure is becoming increasingly realistic...
May 6, 2018: Xenotransplantation
https://www.readbyqxmd.com/read/29731087/seven-years-of-experiences-of-preclinical-experiments-of-xeno-heart-transplantation-of-pig-to-non-human-primate-cynomolgus-monkey
#12
S J Lee, J S Kim, H K Chee, I J Yun, K S Park, H S Yang, J H Park
BACKGROUND: The absolute shortage of donors compared with patients requiring transplantation is currently an unsolved problem, and the only possible solution may be xenotransplantation. To establish a successful clinical trial, a preclinical study using nonhuman primates is essential. Starting in November 2011, our team initiated heterotopic abdominal heart xenotransplantation, the first in the Republic of Korea. We present here the initial 7-year results. METHODS: A total of 22 xenotransplantation procedures have been performed since 2011...
May 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29722120/comparative-efficacy-of-anti-cd40-antibody-mediated-co-stimulation-blockade-on-long-term-survival-of-full-thickness-porcine-corneal-grafts-in-nonhuman-primates
#13
Jaeyoung Kim, Se Hyun Choi, Hyun Ju Lee, Hong Pyo Kim, Hee Jung Kang, Jong Min Kim, Eung Soo Hwang, Chung-Gyu Park, Mee Kum Kim
Porcine corneas may be good substitutes for human corneas in donor shortage. Therefore, we evaluated the efficacy and safety of an anti-CD40 antibody-based regimen compared to an anti-CD20 antibody-based regimen on the survival of full-thickness corneas in pig-to-rhesus xenotransplantation. Thirteen Chinese rhesuses underwent full-thickness corneal xenotransplantation. Six were administered anti-CD40 antibody, and the others were administered anti-CD20 antibody, basiliximab, and tacrolimus. Graft survival and changes in lymphocyte, donor-specific and anti-αGal antibody, and aqueous complement levels were evaluated...
May 2, 2018: American Journal of Transplantation
https://www.readbyqxmd.com/read/29722117/upregulation-of-cd80-on-glomerular-podocytes-plays-an-important-role-in-development-of-proteinuria-following-pig-to-baboon-xeno-renal-transplantation-an-experimental-study
#14
Christopher J Rivard, Tatsu Tanabe, Miguel A Lanaspa, Hironosuke Watanabe, Shunichiro Nomura, Ana Andres-Hernando, Krystle Garth, Mitsuhiro Sekijima, Takuji Ishimoto, Yuichi Ariyoshi, Gabriela E Garcia, Jigesh Shah, Lennan Boyd, Masayuki Tasaki, Thomas Pomposelli, Akira Shimizu, David H Sachs, Richard J Johnson, Kazuhiko Yamada
We have previously reported that co-transplantation of the kidney with vascularized donor thymus from α-1, 3-galactosyl transferase gene knockout pigs, with an anti-CD154 with rituximab-based regimen led to improved xenograft survival in baboons with donor-specific unresponsiveness. However, nephrotic syndrome emerged as a complication in which the glomeruli showed mild mesangial expansion with similarities to minimal change disease (MCD) in humans. Since MCD is associated with CD80 expression in glomeruli and elevated urinary excretion, we evaluated a potential role for CD80 in xenograft nephropathy...
May 2, 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/29721667/the-influence-of-mutational-status-and-biological-characteristics-of-acute-myeloid-leukemia-on-xenotransplantation-outcomes-in-nod-scid-gamma-mice
#15
Martin Culen, Zdenka Kosarova, Ivana Jeziskova, Adam Folta, Jana Chovancova, Tomas Loja, Nikola Tom, Vojtech Bystry, Veronika Janeckova, Dana Dvorakova, Jiri Mayer, Zdenek Racil
PURPOSE: This study aimed at analyzing the association of gene mutations and other acute myeloid leukemia (AML) characteristics with engraftment outcomes in immunodeficient mice and to select the engraftment outcomes that best reflect patient survival. METHODS: Mutations in 19 genes as well as leukemia- and patient-related characteristics were analyzed for a group of 47 de novo AML samples with respect to three engraftment outcomes: engraftment ability, engraftment intensity (percentage of hCD45+ cells) and engraftment latency...
May 2, 2018: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/29719840/local-xenotransplantation-of-bone-marrow-derived-mast-cells-bmmcs-improves-functional-recovery-of-transected-sciatic-nerve-in-cat-a-novel-approach-in-cell-therapy
#16
Rahim Mohammadi, Dana Anousheh, Mohammad-Hazhir Alaei, Amin Nikpasand, Hawdam Rostami, Rasoul Shahrooz
Objective: To determine the effects of bone marrow derived mast cells (BMMCs) on functional recovery of transected sciatic nerve in animal model of cat. Method: A 20-mm sciatic nerve defect was bridged using a silicone nerve guide filled with BMMCs in BMMC group. In Sham-surgery group (SHAM), the sciatic nerve was only exposed and manipulated. In control group (SILOCONE) the gap was repaired with a silicone nerve guide and both ends were sealed using sterile Vaseline to avoid leakage and the nerve guide was filled with 100 μL of phosphate-buffered saline alone...
April 2018: Bulletin of Emergency and Trauma
https://www.readbyqxmd.com/read/29687920/jewish-christian-and-muslim-theological-perspectives-about-xenotransplantation
#17
Wayne Paris, Rabbi Jerry H Seidler, Kevin FitzGerald, Aasim I Padela, Emanuele Cozzi, David K C Cooper
BACKGROUND: This paper is based on a theological symposium presented at the International Xenotransplantation Association's 14th Congress held in Baltimore, MD, September, 2017. METHODS: The information explores the Jewish, Christian and Muslim theological perceptions and perspectives about cross-species (ie pig-to-human) organ transplantation, the genetic alterations required in the organ-source pig, and their potential to influence individual acceptance of the procedure...
April 24, 2018: Xenotransplantation
https://www.readbyqxmd.com/read/29687010/remaining-physiological-barriers-in-porcine-kidney-xenotransplantation-potential-pathways-behind-proteinuria-as-well-as-factors-related-to-growth-discrepancies-following-pig-to-kidney-xenotransplantation
#18
REVIEW
Jigesh A Shah, Miguel A Lanaspa, Tatsu Tanabe, Hironosuke Watanabe, Richard J Johnson, Kazuhiko Yamada
Considerable shortages in the supply of available organs continue to plague the field of solid organ transplantation. Despite changes in allocation, as well as the utilization of extended criteria and living donors, the number of patients waiting for organs continues to grow at an alarming pace. Xenotransplantation, cross-species solid organ transplantation, offers one potential solution to this dilemma. Previous extensive research dedicated to this field has allowed for resolution of xenograft failure due to acute rejection, leaving new areas of unresolved challenges as barriers to success in large animal models...
2018: Journal of Immunology Research
https://www.readbyqxmd.com/read/29683801/social-economic-and-policy-implications-of-organ-preservation-advances
#19
Alyssa Ward, David K Klassen, Kate M Franz, Sebastian Giwa, Jedediah K Lewis
PURPOSE OF REVIEW: Despite over 60 years of progress in the field of since the first organ transplant, insufficient organ preservation capabilities still place profound constraints on transplantation. These constraints play multiple and compounding roles in the predominant limitations of the field: the severe shortages of transplant organs, short-term and long-term posttransplant outcomes and complications, the unmet global need for development of transplant infrastructures, and economic burdens that limit patient access to transplantation and contribute to increasing global healthcare costs...
April 24, 2018: Current Opinion in Organ Transplantation
https://www.readbyqxmd.com/read/29674272/copb2-promotes-cell-proliferation-and-tumorigenesis-through-up-regulating-yap1-expression-in-lung-adenocarcinoma-cells
#20
Xiaolin Pu, Jun Wang, Wei Li, Weifei Fan, Lin Wang, Yuan Mao, Shu Yang, Suyao Liu, Juqing Xu, Zhigang Lv, Lin Xu, Yongqian Shu
Lung adenocarcinoma is the most common subtype of non-small cell lung cancer and responsible for more than 500,000 deaths per year worldwide. In this study, we aimed to explore the effects of COPB2 in the progression of lung adenocarcinoma and its underlying mechanism. The mRNA and protein levels of COPB2 in tumor tissues and cell lines were determined by qRT-PCR and western blotting analysis. siRNAs and over-expressed vector targeting COPB2 were used to down-regulate and up-regulate COPB2 expression in lung adenocarcinoma cell lines H1975...
April 16, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
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