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Appendicitis AND cancer

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https://www.readbyqxmd.com/read/28395768/what-constitutes-an-unmet-medical-need-in-oncology-an-empirical-evaluation-of-author-usage-in-the-biomedical-literature
#1
Eric Lu, Joseph Shatzel, Florence Shin, Vinay Prasad
The phrase "unmet medical need" has important regulatory implications, but there is no empirical analysis of its real world usage. We sought to determine the annual US incidence, 5-year survival, and number of National Comprehensive Cancer Network (NCCN)-recommended regimens for indications described in the literature as an "unmet medical need." We queried Google Scholar to identify publications where authors used the phrase "unmet medical need" to refer to a specific cancer indication. For each indication, we investigated the annual US incidence, 5-year survival, and number of NCCN recommended regimens...
February 2017: Seminars in Oncology
https://www.readbyqxmd.com/read/28288326/a-hybrid-approach-to-appendicitis-with-right-external-iliac-artery-pseudo-aneurysm-a-case-report
#2
Benjamin T Chandler, Evan J Ryer, Benjamin M Keyser, James R Elmore
INTRODUCTION: While acute appendicitis is a common surgical problem, the simultaneous occurrence of appendicitis and an infected iliac artery pseudoaneurysm is exceedingly rare. We report the successful treatment of an infected right external iliac artery pseudo aneurysm in the 1setting of acute appendicitis. PRESENTATION OF CASE: The patient is an 83-year-old male who presents with severe sepsis, right lower quadrant and right leg pain. Additional past medical history is significant for rectal cancer status post resection and radiation therapy in 1997...
March 4, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28154107/impact-of-social-and-built-environment-factors-on-body-size-among-breast-cancer-survivors-the-pathways-study
#3
EDITORIAL
Salma Shariff-Marco, Julie Von Behren, Peggy Reynolds, Theresa H M Keegan, Andrew Hertz, Marilyn L Kwan, Janise M Roh, Catherine Thomsen, Candyce H Kroenke, Christine Ambrosone, Lawrence H Kushi, Scarlett Lin Gomez
Background: As social and built environment factors have been shown to be associated with physical activity, dietary patterns, and obesity in the general population, they likely also influence these health behaviors among cancer survivors and thereby impact survivorship outcomes.Methods: Enhancing the rich, individual-level survey and medical record data from 4,505 breast cancer survivors in the Pathways Study, a prospective cohort drawn from Kaiser Permanente Northern California, we geocoded baseline residential addresses and appended social and built environment data...
April 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28133078/-a-case-of-curatively-resected-goblet-cell-carcinoid-of-the-appendix-diagnosed-via-intraoperative-frozen-sectional-examination
#4
Tomoya Ikeda, Junichiro Yamauchi, Kento Miyazaki, Sho Yasuta, Shota Fujita, Mamoru Satoh, Keiichi Shirasaki, Shin Kobayashi, Takashi Ajiki, Katsuo Tsuchihara, Noriko Kondo, Shuichi Ishiyama
A 52-year-old patient presented with epigastric pain.An enhanced CT scan showed a strongly enhanced appendix with abscess formation.Appendectomy was performed under the diagnosis of acute appendicitis with perityphlitic abscess.The stump of the appendix was white and hard, suggesting malignant transformation.Intraoperative frozen sectional examination indicated goblet cell carcinoid(GCC)of the appendix.Thereafter, we performed ileocecal resection with lymphadenectomy (D3).The final pathological diagnosis was GCC, pSS, pN1, Stage III a by the Japanese classification of colorectal carcinoma...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28121030/the-gut-microbiome-and-the-mechanism-of-surgical-infection
#5
REVIEW
J C Alverdy, S K Hyoju, M Weigerinck, J A Gilbert
BACKGROUND: Since the very early days of surgical practice, surgeons have recognized the importance of considering that intestinal microbes might have a profound influence on recovery from surgical diseases such as appendicitis and peritonitis. Although the pathogenesis of surgical diseases such as cholelithiasis, diverticulosis, peptic ulcer disease and cancer have been viewed as disorders of host biology, they are emerging as diseases highly influenced by their surrounding microbiota...
January 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/28091700/computed-tomography-localization-of-the-appendix-in-the-pediatric-population-relative-to-the-lumbar-spine
#6
John Davis, Albert T Roh, Matthew B Petterson, Tammy R Kopelman, Samantha L Matz, Daniel G Gridley, Mary J Connell
BACKGROUND: Computed tomography (CT) is commonly used to evaluate suspected acute appendicitis. Although very effective, CT uses ionizing radiation, exposing patients to an increased risk of cancer. OBJECTIVE: This study assessed the potential for decreasing the field of view of the CT (and therefore the dose to the patient) in the evaluation of suspected acute appendicitis in children. MATERIALS AND METHODS: This study was a retrospective review of prospectively collected data from 212 consecutive patients who underwent CT for suspected acute appendicitis...
January 14, 2017: Pediatric Radiology
https://www.readbyqxmd.com/read/28088862/self-assembling-peptide-epitopes-as-novel-platform-for-anticancer-vaccination
#7
Mazda Rad-Malekshahi, Marieke F Fransen, Małgorzata Krawczyk, Mercedeh Mansourian, Meriem Bourajjaj, Jian Chen, Ferry Ossendorp, Wim E Hennink, Enrico Mastrobattista, Maryam Amidi
The aim of the present study was to improve the immunogenicity of peptide epitope vaccines using novel nanocarriers based on self-assembling materials. Several studies demonstrated that peptide antigens in nanoparticulate form induce stronger immune responses than their soluble forms. However, several issues such as poor loading and risk of inducing T cell anergy due to premature release of antigenic epitopes have challenged the clinical success of such systems. In the present study, we developed two vaccine delivery systems by appending a self-assembling peptide (Ac-AAVVLLLW-COOH) or a thermosensitive polymer poly(N-isopropylacrylamide (pNIPAm) to the N-terminus of different peptide antigens (OVA250-264, HPV-E743-57) to generate self-assembling peptide epitopes (SAPEs)...
January 27, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28048838/su-f-i-36-in-utero-dose-measurements-within-postmortem-subjects-for-estimating-fetal-doses-in-pregnant-patients-examined-with-pulmonary-embolism-trauma-and-appendicitis-ct
#8
I Lipnharski, N Quails, C Carranza, N Correa, S Bidari, M Bickelhaup, L Rill, M Arreola
PURPOSE: The imaging of pregnant patients is medically necessary in certain clinical situations. The purpose of this work was to directly measure uterine doses in a cadaver scanned with CT protocols commonly performed on pregnant patients in order to estimate fetal dose and assess potential risk. METHOD: One postmortem subject was scanned on a 320-slice CT scanner with standard pulmonary embolism, trauma, and appendicitis protocols. All protocols were performed with the scan parameters and ranges currently used in clinical practice...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/27998075/biotin-decorated-gold-nanoparticles-for-targeted-delivery-of-a-smart-linked-anticancer-active-copper-complex-in-vitro-and-in-vivo-studies
#9
Anup K Pramanik, Siddikuzzaman, Duraippandi Palanimuthu, Kumaravel Somasundaram, Ashoka G Samuelson
The synthesis and anticancer activity of a copper(II) diacetyl-bis(N4-methylthiosemicarbazone) complex and its nanoconjugates are reported. The copper(II) complex is connected to a carboxylic acid group through a cleavable disulfide link to enable smart delivery. The copper complex is tethered to highly water-soluble 20 nm gold nanoparticles (AuNPs), stabilized by amine terminated lipoic acid-polyethylene glycol (PEG). The gold nanoparticle carrier was further decorated with biotin to achieve targeted action...
December 21, 2016: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/27929173/novel-mitochondria-targeted-copper-ii-complexes-of-ferrocenyl-terpyridine-and-anticancer-active-8-hydroxyquinolines-showing-remarkable-cytotoxicity-dna-and-protein-binding-affinity
#10
Banashree Deka, Tukki Sarkar, Samya Banerjee, Arun Kumar, Sanjoy Mukherjee, Sasanka Deka, Kandarpa K Saikia, Akhtar Hussain
Metal complexes with organelle specificity and potent but selective cytotoxicity are highly desirable. In this work, we report the synthesis, characterization and cytotoxicity of six novel copper(ii) complexes of the formula [Cu(R-tpy)(N-O)]NO3 (1-6), where R-tpy is 4'-phenyl-2,2':6',2''-terpyridine (Ph-tpy; 1-3) or 4'-ferrocenyl-2,2':6',2''-terpyridine (Fc-tpy; 4-6), N-O is the anion of 8-hydroxyquinoline (HQ in 1, 4), 5-chloro-7-iodo-8-hydroxyquinoline (CQ in 2, 5) or 5-nitro-8-hydroxyquinoline (NQ in 3, 6)...
January 3, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/27919658/quinolizinium-as-a-new-fluorescent-lysosomotropic-probe
#11
Emmanouil Zacharioudakis, Tatiana Cañeque, Raúl Custodio, Sebastian Müller, Ana M Cuadro, Juan J Vaquero, Raphaël Rodriguez
We have synthesized a collection of quinolizinium fluorescent dyes for the purpose of cell imaging. Preliminary biological studies in human U2OS osteosarcoma cancer cells have shown that different functional groups appended to the cationic quinolizinium scaffold efficiently modulate photophysical properties but also cellular distribution. While quinolizinium probes are known nuclear staining reagents, we have identified a particular quinolizinium derivative salt that targets the lysosomal compartment. This finding raises the question of predictability of specific organelle targeting from structural features of small molecules...
January 15, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/27847444/synthesis-characterization-and-biological-studies-of-a-piperidinyl-appended-dipicolylamine-ligand-and-its-rhenium-tricarbonyl-complex-as-potential-therapeutic-agents-for-human-breast-cancer
#12
Amali Subasinghe, Inoka C Perera, Svetlana Pakhomova, Theshini Perera
A novel ligand bearing a central piperidinyl sulfonamide group, N(SO2pip)dpa, and its corresponding Re tricarbonyl complex, [Re(CO)3(N(SO2pip)dpa)](+), have been synthesized in good yield. The methylene CH2 signal seen as a singlet (4.54 ppm) in a (1)H NMR spectrum of the ligand in DMSO-d6 appears as two doublets (5.39, 5.01 ppm) in a spectrum of the [Re(CO)3(N(SO2pip)dpa)](+) complex and confirms the presence of magnetically nonequivalent protons upon coordination to Re. Structural results revealed that the Re-N bond lengths fall within the normal range establishing coordination of ligand to metal...
2016: Bioinorganic Chemistry and Applications
https://www.readbyqxmd.com/read/27782276/regioselective-synthesis-of-naphthoquinone-naphthoquinol-carbohydrate-hybrids-by-4-2-anionic-annulations-and-studies-on-their-cytotoxicity
#13
Soumen Chakraborty, Gaurav Das, Surajit Ghosh, Dipakranjan Mal
An efficient and regioselective synthetic route to naphthoquinone/naphthoquinol-carbohydrate hybrids has been developed. It is based upon anionic annulation of 3-nucleofugalphthalides with an acrylate appended sugar moiety. In each of the annulations studied, the arene-carbohydrate hybrids were obtained in good to excellent yields. The in vitro cytotoxic activity of the synthetic naphthoquinone/naphthonol-carbohydrate hybrids were evaluated against the human cervical cancer cell line (HeLa), and a few of them were found to exhibit potent anticancer activity against the cell line...
December 7, 2016: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/27779999/appendicitis-in-cancer-patients-is-often-observed-and-can-represent-appendiceal-malignancy
#14
David Santos, Yi-Ju Chiang, Brian Badgwell
Appendectomy is standard of care for uncomplicated appendicitis, but cancer patients may not be optimal surgical candidates. Interval appendectomy is controversial, and appendiceal malignancy is rare. Study objectives were to review the role of surgery, observation, and interventional radiology (IR)-guided drainage in patients with appendicitis and advanced malignancy. Retrospective review was performed on cancer patients presenting to a tertiary academic cancer center from January 1, 2001 to December 31, 2014...
October 2016: American Surgeon
https://www.readbyqxmd.com/read/27722498/a-biotin-guided-formaldehyde-sensor-selectively-detecting-endogenous-concentrations-in-cancerous-cells-and-tissues
#15
Yun Hak Lee, Yonghe Tang, Peter Verwilst, Weiying Lin, Jong Seung Kim
A biotin appended formaldehyde sensor was found to specifically visualise both exogenous and endogenous levels of formaldehyde in biotin receptor positive cells over biotin negative cells by means of one- and two-photon excitation. The probe furthermore visualised endogenous levels of formaldehyde in tumour tissue slices up to 70 μm depth.
September 13, 2016: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/27683008/appendicitis-caused-by-the-metastasis-of-her2-positive-breast-cancer
#16
Ryutaro Mori, Manabu Futamura, Kasumi Morimitsu, Kazuhiro Yoshida
The appropriate therapy for metastatic breast cancer must be selected based on the immunohistochemical phenotype of the cancer. However, biopsy for metastatic lesions is difficult. We herein report a patient with incidental appendicitis caused by a metastatic breast cancer which was successfully treated with effective therapy chosen based on the pathological diagnosis obtained on resection. The patient was a 56-year-old female with right breast cancer and an immunohistochemical status of estrogen receptor (ER) (+), progesterone receptor (PgR) (+), human epidermal growth factor receptor 2 (HER2) (3+), and Ki67 40 %...
December 2016: Surgical Case Reports
https://www.readbyqxmd.com/read/27670880/synthesis-of-first-ever-4-quinolone-3-carboxylic-acid-appended-spirooxindole-pyrrolidine-derivatives-and-their-biological-applications
#17
Thangaraj Arasakumar, Sadasivam Mathusalini, Athar Ata, Ramasamy Shankar, Subashini Gopalan, Krishnasamy Lakshmi, Pandiyarajan Sakthivel, Palathurai Subramaniam Mohan
A series of 4-quinolone-3-carboxylic acid-containing spirooxindole-pyrrolidine derivatives was synthesized via multicomponent 1,3-dipolar cycloaddition reactions of azomethine ylides with new (E)-4-oxo-6-(3-phenyl-acryloyl)-1,4-dihydroquinoline-3-carboxylic acids in good yields with high regioselectivity. The cycloadducts were characterized by analytical and spectral data including [Formula: see text], [Formula: see text], 2D NMR and mass spectroscopy. The structure of one of the compounds (8a) was investigated theoretically by computational techniques...
February 2017: Molecular Diversity
https://www.readbyqxmd.com/read/27612690/solid-inclusion-complexes-of-oleanolic-acid-with-amino-appended-%C3%AE-cyclodextrins-acds-preparation-characterization-water-solubility-and-anticancer-activity
#18
Yufeng Ren, Ying Liu, Zhikuan Yang, Raomei Niu, Kai Gao, Bo Yang, Xiali Liao, Jihong Zhang
Oleanolic acid (OA) is a pentacyclic triterpenoid acid of natural abundance in plants which possesses important biological activities. However, its medicinal applications were severely impeded by the poor water solubility and resultant low bioavailability and potency. In this work, studies on solid inclusion complexes of OA with a series of amino-appended β-cyclodextrins (ACDs) were conducted in order to address this issue. These complexes were prepared by suspension method and were well characterized by NMR, SEM, XRD, TG, DSC and Zeta potential measurement...
December 1, 2016: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/27543724/odd-localisation-for-a-gastric-cancer-histology
#19
Paulina Kuczma, Jordi Vidal Fortuny, Saiji Essia, Ariane de Lassus, Philippe Morel, Frédéric Ris
INTRODUCTION: More than 96% of signet-ring cell carcinomas occur in the stomach and the rest in other organs, including the gallbladder, pancreas, urinary bladder and breast. Primary signet-ring cell carcinoma of the colon and rectum is very rare, accounting for 0.1%-2.4% of all colorectal cancers. PRESENTATION OF CASE: We report a case of a 55-year old man who is operated for a caecal mass evocative of an appendicitis abscess. Intraoperatively, we discover a large, ulcerated ilio-caecal mass with several lymphadenopathies...
2016: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/27512565/appendicitis-complicated-by-appendiceal-metastasis-via-peritoneal-dissemination-from-lung-cancer
#20
Naoki Shiota, Makoto Furonaka, Kazuya Kikutani, Keiko Haji, Seiji Fujisaki, Toshihiro Nishida
Peritoneal disseminations from lung cancer are difficult to detect during the patient's clinical course. Therefore, complications of this condition are unclear. We report a case in which peritoneal dissemination from lung cancer complicated appendicitis. A 74-year-old man with lung cancer who was receiving maintenance therapy presented at our hospital because of abdominal pain. It was the seventh day after the 14th cycle of maintenance therapy with bevacizumab. He was diagnosed with acute appendicitis. The resected appendix showed acute appendicitis complicated by appendiceal metastasis from lung cancer...
July 2016: Respirology Case Reports
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